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Do you have what it takes to save humanity? As skilled members of a disease-fighting team, you must keep
four deadly diseases at bay while discovering their cures.
You and your teammates will travel across the globe, treating infections while finding resources for cures.
You must work together, using your individual strengths, to succeed. The clock is ticking as outbreaks and
epidemics fuel the spreading plagues.
Can you find all four cures in time? The fate of humanity is in your hands!
CONTENTS KHARTOUM
SUDAN
MOSCOW
4,887,000
HÔ CHI MINH VILLE
4,500/KM2
RÉPUBLIQUE POPULAIRE
RUSSIA
DE CHINE
4 900 000
15,512,000 9450/KM22
3,500/KM
1-INCREASE
MOVE THE INFECTION RATE
MARKER FORWARD 1 SPACE.
MONTREAL
ESSEN 2-INFECT
MONTREAL
DRAW THE BOTTOMEVE NT FROM
CARD
PUTNT POP
ULATION
ILIE actions
GERMANY
3 CUBES ON THATRES
THE INFECTION DECK AND
575,000 2,800/KM 2 CITY. DISCARD Not an action.
Play any time.
CANADA
THAT CARD.
SCIE CANADA
MONTREAL MANILA Drive / Ferr
y line.
EVE NT HT by a white
3-INTENSIFY E QUIET NIG
NTIS city connected
Move to a
T PHILIPPINES
SHUFFLE THE CARDS IN THEON an action. the card.
20,767,000 14,400/KM2 Not t named on
Play any time.
INFECTION DISCARD PILE AND DireCt Fligh to the city
CANADA
PUT THEM ON TOP OF THE card to move
Discard a City
INFECTION DECK. in to move
t city you are
SUDAN
Charter Flighcard that matches the
City
Discard the
KHARTOUM
a researc h
to any city. ON
CITY
CITY ARCH STATIhases the city you are in to place
CITY BUILD A RESE thatthat
cardcity match
t Cityother
theany
Shuttle Fligh Discardto
DE CHINE
ch station
RUSSIA CITY
with a resear
RÉPUBLIQUE POPULAIRE
a city station there.
HÔ CHI MINH VILLE
MOSCOW Move from
station. this color is
cured, remove
reMove Any 1 cArd in the infection a research SE in. If
TREAT DISEA e cube from the city you are
discArd pile froM the GAMe. Remove 1 diseas the city.
that color from
you MAy plAy this between the infect And all cubes of
GERMANY
• Yo another player, or
u ne ESSEN intensify steps of An epideMic. LEDGE you are in to
SHARE KNOWcard that matches the city player must also be in the
city
color ed only
4 ca
actio to do th
the other
rd Either: give r player. The
n. e Disc s of th skip the next infect cities step from anothe
over e sa take that card
a Cu me (do not flip over Any infection cArds).
PHILIPPINES
CITY CITY
re CITY with you.
e color to
the same diseas
MANILA A CURE
DISCOVER 5 City cards of
h station, discard
At any researc
e.
cure that diseas
CITY
KHARTOUM
SUDAN
BAGHDAD
IRAQ
CHICAGO
UNITED STATES 1 Infection rate
HO CHI MINH CITY
VIETNAM marker
Eradication
“ ” side
48 Infection cards 96 Disease cubes
1 Outbreaks marker
24 in 4 colors 4 Cure markers
1
Each player has a specific role with special abilities to improve the team’s chances.
SETUP
Research stations
Place the board within easy reach of all players. Put the 6 research
stations and disease cubes nearby. Separate the cubes by color into
4 supply piles. Place 1 research station in Atlanta.
Atlanta is home to the CDC, the Center for Disease Control and
Prevention.
lon don eS
Disease cubes eY
alg ierS
SY dn
loS ang ele S
MiaM i
Mex ico citY
lag oS
Bog ot á
kinS haS a
Place the outbreaks marker on the “0” space of the Bue noS aire S
J
San tiag o
Outbreaks Track. Place the 4 cure markers, “vial” side up,
near the Discovered Cure Indicators.
Outbreak marker
Outbreak track
SCIENTIST
actions
DireCt Flight
Discard a City card to move to the city named on the card.
Charter Flight
Discard the City card that matches the city you are in to move
Give each player a reference card. Shuffle the Role cards and to any city.
Shuttle Flight
CITY
CITY
CITY
CITY
• You need only 4 cards of the same
deal 1 face up in front of each player. Place the matching
Move from a city with a research station to any other city that has
color to do the Discover a Cure a research station.
action.
# of players Cards
2-player game 4
M
0/K 2
8,77002 COLO
,000
BO,0G00O MBIA
2
3-player game 3
21,000
/KM 4,715 ATESTÁ
2
E D ST
UNIT TA
4-player game 2
AN
ATL
Infection Rate Marker
ho chi Man ila Use disease cubes matching the card colors.
Minh citY
SYd neY
lo S
an ge
le S
6 Begin play
The players look at the City cards they have in their hand.
1.Do 4 actions
2.Draw 2 card
s The player with the highest City population goes first.
•Resolve any epide
mics
•Discard to 7 card
s
3.Infect cities
Stack
PLAY
Each player turn is divided into 3 parts:
1. Do 4 actions.
MONTREAL
MONTREAL
MONTREAL
CANADA
CANADA
CANADA
5 Prepare the Player Deck everyone offer opinions and ideas. However, the player
whose turn it is decides what to do.
Set the game’s difficulty level, by using either 4, 5, or 6 Epidemic cards, for Your hand can have City and Event cards in it.
an Introductory, Standard, or Heroic game. Remove any unused Epidemic City cards are used in some actions and Event cards
cards from the game. can be played at any time.
Divide the remaining player cards into face down piles, as equal in size as
you can, so that the number of piles matches the number of Epidemic cards
you are using. Shuffle 1 Epidemic card into each pile, face down. Stack these
3
piles to form the Player Deck, placing smaller piles on the bottom.
ACTIONS
You may do up to 4 actions each turn.
Select any combination of the actions listed below. You may do the same action
several times, each time counting as 1 action. Your role’s special abilities may change
how an action is done. Some actions involve discarding a card from your hand; all these
discards go to the Player Discard Pile.
Move to a city connected by a white line to the one you are in.
eSSen
london
MoScow
Milan
chicago MontrÉal Seoul
new York
PariS BeiJing
San FranciSco tehran
tokYo
tokYo
iStanBul San
FranciSco
Manila
Madrid Baghdad Shanghai
waShington delhi
Direct Flight
Mexico citY riYadh
lagoS
MuMBai
khartouM
San
Bogot á FranciSco
chennai
Manila
ho chi
Jakarta
liMa
S ã o Paulo
JohanneSBurg
loS
leS
ange
BuenoS aireS
Santiago SYdneY
1.Do 4 actions
2.Draw 2 cards
•Resolve any epidemics
Charter Flight
•Discard to 7 cards
3.Infect cities
Discard the City card that matches the city you are in to move to any city.
A white line that goes off the board “wraps around”
CITY
CITY to the other edge and connects to a city.
CITY
Example: Sydney and Los Angeles are connected.
Shuttle Flight
CITY
Move from a city with a research station to any other city that has a
research station.
OTHER ACTIONS
Build a Research Station
iscard the City card that matches the city you are in to place a research
D If more than 6 research stations were supplied,
station there. Take the research station from the pile next to the board. If all set any extra aside during setup.
6 research stations have been built, take a research station from anywhere
on the board.
The other player must also be in the city with you. Both of you need to
the Moscow card and you both are in
CANADA
If the player who gets the card now has more than 7 cards, that player must
RUSS LE
CITYCITY immediately discard a card or play an Event card (see Event Cards on page 7). agree before handing the card over.
Discover a Cure
At any research station, discard 5 City cards of the same color from your When a disease is cured, its cubes remain on the
hand to cure the disease of that color. Move the disease’s cure marker to its board and new cubes can still be placed during
Cure Indicator. epidemics or infections (see Epidemics and
Infections on page 6). However, treating this disease
If no cubes of this color are on the board, this disease is now eradicated.
is now easier and you are closer to winning.
4
Flip its cure marker from its “vial” side to its “ ” side.
rSBurg MoScow
Seoul
BeiJing
tehran
chicago tokYo
MontrÉa
San
FranciSco
Play Example: On the first turn, Ben does 4 actions:
Baghdad Shanghai
San FranciSco 2
(1) Drive
MoScow
to Chicago (from Atlanta), (2) Drive to San Francisco,
delhi
(3) Treat Disease in San Francisco, removing a blue disease cube
tokY o 1 St. PeterSBurg
there, and (4) Treat Disease in San Francisco again, removing a 4
second blue disease cube. karachi 3
kolkata eSSen
M a n il a london
Ben has finished the Actions part of his turn.
St. PeterSBurg hong
eSSen kong BeiJing
oSaka
atlanta Milan
chicago MontrÉal tehran
new York
PariS taiPei
San FranciSco MoScow Bangkok
Milan
kYo Play Example: Later in the game, the red disease has been cured. 1 iStanBul
Seoul
riYadh neY
ariS
a n il a SYd
Madrid BeiJing
3 red cubes remain on the board inMuMBai tehran
waShington
Manila, where Anna the Scientist loS angeleS
(white pawn) begins her turn. Anna (1) Treats Disease in Manila,
Baghdad Shanghai
tokYo
khartouM
removingiStanBul atlanta
all 3 cubes with one action (since this disease has been
cured). This eradicates the red disease, so the red cure marker is
delhi
Shanghai
algierScitY
Mexico Sa n
Fr an ci Sc
San
FranciSco
o
flipped over to its “ ” side.
Baghdad delhi
chennai cairo
algierS
SYd
neY
loS angeleS
karachi
karachi
MiaMi
kolkata
ho chi kolkata
Manila
Minh citYhong
Mexico citY kong oSaka
cairo lagoS
taiPei
Bangkok
khar
George, the Operations Expert (green pawn), is in BogotMAá NILA Jakarta
lagoS Chennai, having built a research stationriYadh
there. PHILIPPINES
20,767,000
14,400/KM 2
George tells Anna that he has the Chennai City card MuMBai
khartouM
in his hand and offers to let Anna take it from him
2
if she can get to Chennai. Anna discards her Manila
City card for a (2) Charter Flight, moving her pawn chennai
Bangkok
kinShaSa
Sa n
Fr an ci Sc
o
to Chennai.
PHILIPPINES
MANILA liMaManila
SBurg ho chi loS S
Minh citY le
kinShaSa riYadh
liMa
S ã o Paulo
ange
CHEN
HÔ CHNA 3
I NH
I MI
SYdneY
MuMBai
RÉPUBLIQUE POP VILLE
INDIA
DE CHINE ULAIRE
Jakarta
4 900
8,86 5,00
Anna then (3) Shares Knowledge with George, taking
000
0 9450/K
14,60 0/KMM22
his Chennai card. Doing this gives Anna 4 black cards, JohanneSBurg
CANADA EAL
khartouM
which is not enough to cure a disease.
MONTR
4
BuenoS aireS
DE CHINE ULAIRE
RÉPUBLIQUE POP VILLE
INDIA
I NH
I MI Santiago
1.Do 4 actions
Santiago
CHNA
CHEN
HÔ
•Discard to 7 cards
3.Infect cities SYdneY
However, Anna is the Scientist and needs to discard only 4 cards of TEHR
HÔ CHAN
RÉP
RIYAD
I MINHHÔ
IRANCHIN
CHH MUMB
HÔ
LEI MINH VILLE
VILRÉP RÉP
UBLIQUE POPULA DE UBL
SAUDI
CHEN
MINHHÔ
CHIAI
IQUE
CHNA I
LEI MINH VILLE
VILRÉP INDIAUBLIQUE UBLIQUE POPULA
INDIACHIN
DE E IRE CHIN E BIAPOPULAIREDE CHINE POPULAIRE
ARA DE E IRE
the same color to cure the corresponding disease. Anna (4) Discovers 4 900,000
7,419 000 4 900
5,03
94500/KM
9,50
7,00
/KM 22
000
0 4 900,000
16,910
94500/KM
3,40 /KM 22
000 4 900
8,86
945000/K
30,9
5,00
000
/KM 2M 2
0 94500/KM
14,60 /KM 22
MONTREAL
MONTREAL
MONTREAL
The black cure marker is moved to the Black Cure Indicator. 1.Do 4 actions
CANADA
CANADA
CANADA
CANADA
Anna has finished the Actions part of her turn. IRECHIN E IRE
CHIN IQUE POPULA DEECHINARA IRE
BIA E
DE CHIN IRE E
2.Draw 2 cards
DE POPULA DE UBLIQUE POPULA
RÉPDI IQUE POPULA
•Resolve any epidemics
RÉPUBLIQUENH
INDIA VILINDIA SAU VILIRAN
LE VILLE I MINH VILLE
LEUBL
RÉP UBL RÉP
CHEN
HÔ CHNA I MI
I HÔMUMB CHIAI MINH HÔ CHH
RIYAD I MINHHÔ TEHR CHAN
•Discard to 7 cards
3.Infect cities
Jakarta 5
PariS
San FranciSco
tokYo
iStanBul
DRAW CARDS
Ma ni la
waShington Madrid
atlanta algierS
After doing 4 actions, draw the top 2 cards together from the Player
Deck. INFECTIONS
If, as you are n e Yabout to draw, there are fewer than 2 cards left
Flip over as many Infection cards from the top of the Infection Deck as cairo
the
SYd
in the Player Deck, loSthe game ends and your team has lost!
angeleS MiaMi
current infection rate. This number is below the space of the Infection Rate
(Do not reshuffle the discards to form a new deck.) Track that has the infection rate marker. Flip these cards over one at a time,
Mexico citY infecting the city named on each card. lagoS
EPIDEMIC CARDS To infect a city, place 1 disease cube matching its color onto the city, unless
If your draws include any Epidemic cards, immediately do the following this disease has been eradicated. If the city already has 3 cubes of this color,
Bogot á
steps in order: do not place a 4th cube. Instead, an outbreak of this disease occurs in the city
(see Outbreaks below). Discard this card to the Infection Discard Pile.
1. Increase: Move the infection rate marker forward 1 space on the
Infection Rate Track.
St. PeterSBurg kinShaSa
2. Infect: Draw the bottom card from the eSSenInfection Deck. Unless its
disease color has beenlondon
eradicated, put 3 disease cubes of that color on
the named city. If the city already has cubes of this color, do not add
liMa
3 cubes to it. Instead, add just enough cubes so that it has 3 cubes of MoScow
Milan S ã o Paulo
this color and then an outbreak of this disease occurs in the city (see
Seoul
ew York Outbreaks below). Discard this card to the Infection Discard Pile. SEOUL PARIS ALGIERS
PariS SOUTH KOREA FRANCE BeiJing ALGERIA
tehran JohanneSBur
If you cannot place the number of cubes actually needed on
the board, because there are not enough cubes of the needed
iStanBul BuenoS aireS
color left in the supply, the game ends and your team has Shanghai
Shington Madrid Santiago Baghdad delhi
lost! This can occur during an epidemic, an outbreak, or
infections (see Outbreaks and Infections below). karachi kolkata
algierS
3. Intensify: Reshuffle just the cards in the Infection Discard Pile and hong
place them on top of the Infection Deck. kong
cairo
When doing these steps, remember to draw from the bottom taiPei
of the Infection Deck and to then reshuffle only the Infection Bangkok
Discard Pile, placing it on top of the existing Infection Deck.
lagoS riYadh Play Example (cont.): Anna ends her turn by infecting cities. The current
infection rate is 3, so Anna flips over the top 3 Infection cards: Seoul,
MuMBai
It is rare but possible to draw 2 Epidemic cards at once. In this case, do
khartouM then Paris, then Algiers.
all three steps above once and then again.
The red disease is eradicated, so Anna simply discards the Seoul card.
In this case in the second epidemic’s Infection card will be the chennai
only card to “reshuffle”, ending on top of the Infection Deck. Paris has a blue cube on it, so Anna adds a second blue cube there and Manil
ho chi
An outbreak will then occur in this city during Infections (see discards the Paris card. Minh citY
Infections, below), unless an EventkinShaSa
card is played to prevent this The black disease has been cured — but not eradicated St.(black
PeterSBurg
cubes are
(see Event Cards on page 7). still on the board) — so Anna must infect Algiers. Since 3 black disease
eSSen
cubes are already in Algiers, Anna doesJakarta
not place a 4th cube there.
After resolving any Epidemic cards, remove them from the game. london
Instead, a black disease outbreak happens in Algiers.
Do Snot
ã o draw
Pauloreplacement cards for them.
2.Draw 2 card
14,100/KM
Madrid Ba
20,464,000
•Resolve any
1,800/KM 2
•Discard to
so Anna continues her turn.
CANADA
3.Infect cities
PERU
atlanta
LIMA
TES
UNITED STA
NEW YORK algierS
6
cairo
MiaMi
itY
TURN END
OUTBREAKS After infecting cities and discarding Infection cards, your turn is over.
The player on your left begins a turn.
When a disease outbreak occurs, move the outbreaks marker forward
1 space on the Outbreaks Track. Then, place 1 cube of the disease color
on every city connected to the city. If any of them already has 3 cubes of EVENT CARDS
the disease color, do not place a 4th cube in those cities. Instead, in each of During a turn, any player may play Event cards. Playing
EVE NT
AIRLIFT
them, a chain reaction outbreak occurs after the current outbreak is done.
final size marks Play any time.
Not an actio
n.
cities that have already had an outbreak (or a chain reaction as Get perMission before MovinG
Another plAyer’s pAwn.
PLAYER CARDS
San FranciSco
Madrid tokYo
Baghdad iStanBul Shangha
Ma nil a
delhi
Madrid Baghdad
waShington When playing the Introductory game (4 Epidemic cards), place your delhi
Milan
city connected to CairoMoScow
Riyadh, and Khartoum — but not Algiers, GAME END
— Istanbul, Baghdad, S ã o Paulo chennai
as Algiers has already had an outbreak while JohanneSBurg
The players win as soon as cures to all 4 diseases are discovered. Seoul
resolving this Infection card. Then, Anna discards
BuenoS aireS BeiJing
the Algiers Infection card.
kinShaSa
Santiago
tehran
The players do not have to eradicate all 4 diseases to win;
just cure them. Once all diseases are cured, the game ends and players
iStanBul win immediately, no matter how many cubes are on the board.
Jakarta
Baghdad Shanghai
delhi
There are 3 ways for the game to end and the players to lose:
ulo karachi kolkata
• if the outbreaks marker reaches the last space of the Outbreaks Track,
• if you are unable to place the number of disease cubes actually
needed on the board, or hong
JohanneSBurg kong
cairo • if a player cannot draw 2 Player cards after doing his actions.
taiPe
7
Bangkok
S riYadh
MuMBai
ROLES
Each player has a role with special abilities to improve your team’s chances.
CONTINGENCY
PLANNER
CONTINGENCY PLANNER OPERATIONS
EXPERT
OPERATIONS EXPERT
The Contingency Planner may, as an action, take an The Operations Expert may, as an action, either:
Event card from anywhere in the Player Discard Pile
• b uild a research station in his current city without
and place it on his Role card. Only 1 Event card can be
discarding (or using) a City card, or
on his role card at a time. It does not count against his
• As an action, take any discarded • As an action, build a research
Event card and store it on this card. station in the city you are in
• When you play the stored Event (no City card needed).
MEDIC
take any 1 of your City cards.
The Medic also prevents placing disease cubes (and outbreaks) of cured
diseases in his location.
CREDITS
Game design: Matt Leacock
Artwork: Chris Quilliams
COMMONLY OVERLOOKED Special thanks to Donna Leacock, Hillary Carey, Chris and Kim Farrell, Rich
Fulcher, Ken Tidwell, Corbin Nash, Jim Cote, Steve Duff, Wei-Hwa Huang, and,