Indian Institute of Integrative Medicine, Jammu
Chemical Engineering & Design Division
Overview
Chemical Engineering and Design Division of
IIIM, Jammu is engaged in process development
and scale-up of laboratory processes on pilot
plant. Generally extraction processes are carried
out on various herbal/medicinal plants. These
extraction processes are scaled-up from 100/500
g laboratory-scale to 15-20 kg pilot plant scale
processes. Thereafter their various process
parameters are optimized, in order to maximize
the yield of these extractions.
Missions and goals
To Scale-up and optimize laboratory
scale processes, in order to develop
cGMP compliant and commercially viable
technologies transferable to user
industry.
Competencies
Develop standardized & quality traditional
medicines which are affordable to
community
Develop new rational formulation of
traditional drugs.
Generate sufficient data for effective
regularization and control of herbal /
traditional medicines moving into
international markets.
Chemical Engineering & Design Division, CSIR-IIIM, Jammu
Generate authentic and accurate,
clinically acceptable data, which can
potentially lead to new IPR’s.
Objectives
 To obtain “New process data”
 Improve Yields and
Conversions
Evaluation of Products & By-products
 Preliminary cost estimation
In order to Maximize yield,
Optimisation of following process
parameters is carried out: Plant Mat./
Solvent Ratio; Temperature of
Extraction Number of Extractions;
Time of each extraction.
Process Development and scale up of
chemical processes from laboratory
to pilot scale. For this purpose, a
multipurpose batch extraction pilot
plant, developed, designed and
fabricated in IIIM Jammu is presently
being used. A new computer
controlled cGMP extraction plant has
been installed and commissioned in
chemical engineering (IIIM Jammu)
Page 1
 for this purpose. compliant Herbal drugs extraction pilot
plant for M/S Tropical Botanics , Malaysia
Plant Capacity: To process around
15-20 kg of material per batch. Facilities
Up scaling carried out from 100 g to One old solvent extraction plant along with
15/20 kg scale solvent recovery system, concentration unit and
drying unit
Purpose to reduce STEPS, reduce Second complete cGMP Herbal Drugs Extraction
SOLVENTS and increase SAFETY of unit was designed, fabricated, installed and
lab. commissioned in March 2009 at IIIM, Jammu.
The major equipments of the plant are as
Processes during their scale up on
follows:-
pilot scale.
Plant material air dryer.
Area of research
Plant material Grinder and
screening system.
Scaled up and optimized process on pilot
plant for the extraction of Tinospora R.O. plant for process water.
cordifolia. The technology was
Extraction system with
transferred to M/S Nicholas Piramal,
condensers breathers and
Mumbai.
automatic material handling
Scaled up and optimized process on pilot system
plant for the extraction of Calcitriol from
Batch solvent storage tanks
Cestrum diurnum. The technology was
transferred to M/S Genova Biotech Ltd. Solvent recovery unit with
Hyderabad.. condenser, breather and storage
tanks.
Scaled up and optimized process on pilot
plant for the extraction of Acteoside from Wiped film evaporator with
Colebrookia opp. The technology was accessories.
transferred to M/S Ochoa Pharma, New
Delhi. Vacuum pan drier.

Scaled up and optimized process on pilot Vacuum tray drier

plant for the extraction of Hyperforin and
Spray drier
Hypericin from Hypericum perforatum.
The technology was transferred to M/S Dry Extract sealing unit.
Nicholas Piramal, Mumbai.

Executed the turnkey project of cGMP

Chemical Engineering & Design Division, CSIR-IIIM, Jammu Page 2

The plant has been installed on proper steel
structure and following utilities were also installed
with appropriate header lines for inlet and outlet
of water, chilled water, air, vacuum and steam
etc.
Extraction step optimized on pilot scale.
Color absorption/adsorption and final
concentration and drying in development
stage.

Boiler – Cap- 600kg/h (Thermax Aim to obtain white crystalline powder

make) extract.

Cooling tower SIMAP Project for Steam distillation &

Fractionation of Mint oil at KanyaKumari.
Chilling plant
Projects
Air compressor
National facility project “ cGMP
Vacuum pumps pilot plant for Extraction,
Formulation and Packaging of
The entire plant is controlled by PLC/computer
Traditional (ISM) herbal
with by pass lines for manual operation.
Medicinal formulation” financed
by IIIM Jammu, DST New Delhi,
and Ayush.
Current research
Process development for extraction of
Stevioside/Rebaudioside rich extract from
Stevia (Industry Linkage- Sahara India)

People

Name Expertise E-mail

Er. Anil Kumar Katare Chemical process development, scale-up akkatare@iiim.ac.in

and optimization. Designing of multipurpose
herbal drugs extraction plants, Steam
distillation units, dryers and other process
equipment like distillation columns,
evaporators, heat exchangers and pressure
vessels.

Chemical Engineering & Design Division, CSIR-IIIM, Jammu Page 3

Mrs. Suman Koul Experience in chemical process sumankoul@iiim.ac.in
development, scale-up and optimization.
Operation of herbal drugs extraction plants
and other pilot plants

Sat Pal Operation and maintenance of extraction

and other chemical Engg. pilot plants

Chemical Engineering & Design Division, CSIR-IIIM, Jammu Page 4