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Ankylosing spondylitis is a form of chronic inflammation of the spine and the sacroiliac
joints. The sacroiliac joints are located in the low back where the sacrum (the bone
directly above the tailbone) meets the iliac bones (bones on either side of the upper
buttocks). Chronic inflammation in these areas causes pain and stiffness in and around
the spine. Over time, chronic spinal inflammation (spondylitis) can lead to a complete
cementing together (fusion) of the vertebrae, a process referred to as ankylosis. Ankylosis
leads to loss of mobility of the spine.
Ankylosing spondylitis is also a systemic rheumatic disease, meaning it can affect other
tissues throughout the body. Accordingly, it can cause inflammation in or injury to other
joints away from the spine, as well as other organs, such as the eyes, heart, lungs, and
kidneys. Ankylosing spondylitis shares many features with several other arthritis
conditions, such as psoriatic arthritis, reactive arthritis, and arthritis associated with
Crohn's disease and ulcerative colitis. Each of these arthritic conditions can cause disease
and inflammation in the spine, other joints, eyes, skin, mouth, and various organs. In
view of their similarities and tendency to cause inflammation of the spine, these
conditions are collectively referred to as "spondyloarthropathies." For more information,
please read the following articles; Psoriatic Arthritis, Reactive Arthritis, Crohn's Disease
and Ulcerative Colitis.
Ankylosing spondylitis is 2-3 times more common in males than in females. In women,
joints away from the spine are more frequently affected than in men. Ankylosing
spondylitis affects all age groups, including children. The most common age of onset of
symptoms is in the second and third decades of life.
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ankylosing spondylitis is 12% (6 times greater than for those whose relatives do not have
ankylosing spondylitis).
How inflammation occurs and persists in different organs and joints in ankylosing
spondylitis is a subject of active research. Each individual tends to have their own unique
pattern of presentation and activity of the illness. The initial inflammation may be a result
of an activation of body's immune system by a bacterial infection or a combination of
infectious microbes. Once activated, the body's immune system becomes unable to turn
itself off, even though the initial bacterial infection may have long subsided. Chronic
tissue inflammation resulting from the continued activation of the body's own immune
system in the absence of active infection is the hallmark of an inflammatory autoimmune
disease.
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The symptoms of ankylosing spondylitis are related to inflammation of the spine, joints,
and other organs. Fatigue is a common symptom associated with active inflammation.
Inflammation of the spine causes pain and stiffness in the low back, upper buttock area,
neck, and the remainder of the spine. The onset of pain and stiffness is usually gradual
and progressively worsens over months. Occasionally, the onset is rapid and intense. The
symptoms of pain and stiffness are often worse in the morning, or after prolonged periods
of inactivity. The pain and stiffness are often eased by motion, heat and a warm shower in
the morning. Because ankylosing spondylitis often affects patients in adolescence, the
onset of low back pain is sometimes incorrectly attributed to athletic injuries in younger
patients.
Patients who have chronic, severe inflammation of the spine can develop a complete
bony fusion of the spine (ankylosis). Once fused, the pain in the spine disappears, but the
patient has a complete loss of spine mobility. These fused spines are particularly brittle
and vulnerable to breakage (fracture) when involved in trauma, such as motor vehicle
accidents. A sudden onset of pain and mobility in the spinal area of these patients can
indicate bone breakage (fracture). The lower neck (cervical spine) is the most common
area for such fractures.
Chronic spondylitis and ankylosis cause forward curvature of the upper torso (thoracic
spine), limiting breathing capacity. Spondylitis can also affect areas where ribs attach to
the upper spine, further limiting lung capacity. Ankylosing spondylitis can cause
inflammation and scarring of the lungs, causing coughing and shortness of breath,
especially with exercise and infections. Therefore, breathing difficulty can be a serious
complication of ankylosing spondylitis.
Patients with ankylosing spondylitis can also have arthritis in joints other than the spine.
Patients may notice pain, stiffness, heat, swelling, warmth, and/or redness in joints such
as the hips, knees, and ankles. Occasionally, the small joints of the toes can become
inflamed, or "sausage" shaped. Inflammation can occur in the cartilage around the breast
bone (costochondritis) as well as in the tendons where the muscles attach to the bone
(tendinitis) and ligament attachments to bone. Some patients with this disease develop
Achilles tendinitis, causing pain and stiffness in the back of the heel, especially when
pushing off with the foot while walking up stairs. Inflammation of the tissues of the
bottom of the foot, plantar fasciitis, occurs more frequently in persons with ankylosing
spondylitis.
Other areas of the body affected by ankylosing spondylitis include the eyes, heart, and
kidneys. Patients with ankylosing spondylitis can develop inflammation of the iris, called
"iritis." Iritis is characterized by redness and pain in the eye, especially when looking at
bright lights. Recurrent attacks of iritis can affect either eye. In addition to the iris, the
ciliary body and choroid of the eye can become inflamed and this is referred to as uveitis.
Iritis and uveitis can be serious complications of ankylosing spondylitis that can damage
the eye and impair vision, and may require an eye specialist's (ophthalmologist) urgent
care. Special treatments for serious eye inflammation are discussed in the treatment
section below. [It should be noted that iritis and inflammation of the spine can occur in
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other forms of arthritis such as reactive arthritis (formerly Reiter's syndrome), psoriatic
arthritis, and the arthritis of inflammatory bowel disease.]
Advanced spondylitis can lead to deposits of protein material called amyloid into the
kidneys and result in kidney failure. Progressive kidney disease can lead to chronic
fatigue and nausea and can require removal of accumulated blood poisons by a filtering
machine (dialysis).
The examination can demonstrate signs of inflammation and decreased range of motion
of joints. This can be particularly apparent in the spine. Flexibility of the low back and/or
neck can be decreased. There may be tenderness of the sacroiliac joints of the upper
buttocks. The expansion of the chest with full breathing can be limited because of rigidity
of the chest wall. Severely affected persons can have a stooped posture. Inflammation of
eyes can be evaluated by the doctor with an ophthalmoscope.
Further clues to the diagnosis are suggested by x-ray abnormalities of the spine and the
presence of the blood test genetic marker, the HLA-B27 gene. Other blood tests may
provide evidence of inflammation in the body. For example, a blood test called the
sedimentation rate is a nonspecific marker for inflammation throughout the body, and is
often elevated in conditions such as ankylosing spondylitis. Urinalysis is often done to
look for accompanying abnormalities of the kidney as well as to exclude kidney
conditions that may produce back pain that mimics ankylosing spondylitis. Patients are
also simultaneously evaluated for symptoms and signs of other related
spondyloarthropathies, such as psoriasis, venereal disease or dysentery (reactive arthritis
or Reiter's disease), and inflammatory bowel disease (ulcerative colitis or Crohn's
disease).
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The treatment of ankylosing spondylitis involves the use of medications to reduce
inflammation and/or suppress immunity, physical therapy, and exercise. Medications
decrease inflammation in the spine, and other joints and organs. Physical therapy and
exercise help improve posture, spine mobility and lung capacity.
Aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) are commonly used to
decrease pain and stiffness of the spine and other joints. Commonly used NSAIDs
include indomethacin (Indocin), tolmetin (Tolectin), sulindac (Clinoril), naproxen
(Naprosyn), and diclofenac (Voltaren). Their common side effects include stomach upset,
nausea, abdominal pain, diarrhea, and even bleeding ulcers. These medicines are
frequently taken with food in order to minimize side effects.
In some patients with ankylosing spondylitis, inflammation of joints excluding the spine
(such as the hips, knees, or ankles) become the major problem. Inflammation in these
joints may not respond to NSAIDs alone. In these patients, the addition of medications
that suppress the body's immune system are considered. These medications, such as
sulfasalazine (Azulfidine), may bring about long-term reduction of inflammation. An
alternative to sulfasalazine that is somewhat more effective is methotrexate (Rheumatrex,
Trexall), which can be administered orally or by injection. Frequent blood tests are
performed during methotrexate treatment because of its potential for toxicity to the liver,
which can even lead to cirrhosis, and toxicity to bone marrow, which can lead to severe
anemia.
Recent research has shown that for persistent ankylosing spondylitis with spinal
involvement that is unresponsive to antiinflammatory medications, both sulfasalazine and
methotrexate are ineffective. Newer, effective medications for spine disease attack a
messenger protein of inflammation (called TNF). These TNF-blocking medications have
been shown to be extremely effective for treating ankylosing spondylitis by stopping
disease activity, decreasing inflammation, and improving spinal mobility. Examples of
these TNF-blockers include etanercept (Enbrel), infliximab (Remicade), and adalimumab
(Humira).
World's experts in the field of ankylosing spondylitis made several major points. There is
an early, under-diagnosed stage of spondylitis that occurs before plain x-ray testing can
detect classic changes. Patients who are treated earlier respond better to treatments.
Current disease-modifying drugs, such as methotrexate, sulfasalazine, and leflunomide
(Arava), which can be effective for joint inflammation of joints away from the spine, are
NOT effective for spinal inflammation. If nonsteroidal antiinflammatory drugs (NSAIDs)
are not effective in a patient whose condition is dominated by spinal inflammation (and
50% do respond), then biologic medications that inhibit tumor necrosis factor (TNF
inhibitors) are indicated. All TNF inhibitors, including Remicade, Enbrel, and Humira are
effective in treating ankylosing spondylitis. The improvement that results for TNF
inhibition is sustained during years of treatment. If the TNF inhibitors are discontinued,
for whatever reason, relapse of disease occurs in virtually all patients in a year. If TNF
inhibitor is then resumed, it is typically effective.
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Oral or injectable corticosteroids (cortisone) are potent anti-inflammatory agents and can
effectively control spondylitis and other inflammations in the body. Unfortunately,
corticosteroids can have serious side effects when used on a long-term basis. These side
effects include cataracts, thinning of the skin and bones, easy bruising, infections,
diabetes, and destruction of large joints, such as the hips.
Exercise programs are customized for the individual patient. Swimming is preferred, as it
avoids jarring impact of the spine. Ankylosing spondylitis need not limit a patient's
involvement in athletics. Patients can participate in carefully chosen aerobic sports when
their disease is inactive. Aerobic exercise is generally encouraged as it promotes full
expansion of the breathing muscles and opens the airways of the lungs.
Inflammation and diseases in other organs are treated separately. For example,
inflammation of the iris of the eyes (iritis or uveitis) may require cortisone eye drops
(pred forte) and high doses of cortisone by mouth. Additionally, atropine eye drops are
often given to relax the muscles of the iris. Sometimes injections of cortisone into the
affected eye are necessary when the inflammation is severe. Heart disease in patients with
ankylosing spondylitis may require a pacemaker placement or medications for congestive
heart failure.
Patients may need to modify their activities of daily living and adjust features of the
work-place. For example, workers can adjust chairs and desks for proper postures.
Drivers can use wide rear-view mirrors and prism glasses to compensate for the limited
motion in the spine.
Finally, patients who have severe disease of the hip joints and spine may require
orthopedic surgery.
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research. The relationship between infectious agents and the triggering of chronic
inflammation is vigorously being pursued. Factors that perpetuate "auto-immunity" are
being identified. The characteristics of the gene marker HLA-B27 are being further
defined. In fact, there are now known to be seven different subtypes of HLA-B27.
Results of ongoing research will lead to a better understanding and treatment of the group
of diseases collectively known as spondyloarthropathies.
For more information about Ankylosing Spondylitis, please visit Arthritis Foundation
(http://www.arthritis.org/).
Reference:
Clinical Primer of Rheumatology, Lippincott Williams & Wilkens, edited by William
Koopman, et. al., 2003.
Kelley's Textbook of Rheumatology, W B Saunders Co, edited by Shaun Ruddy, et.al.,
2000.
American College of Rheumatology Annual Scientific National Meeting, 2005.