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1 Title A COMPARATIVE CLINICAL STUDY ON THE EFFECT OF RASNASAPTAK KWATH
AND VISHWADI KWATH IN KATIGRAHA
2 Research Is there any difference between the effect of Rasnasaptak Kwath and Vishwadi Kwath on
Question Katigraha?
3 Null Hypothesis-
Hypothesis
- There is no significant difference between the effect of Rasnasaptak Kwath and Vishwadi
kwath in Katigraha.
Alternative Hypothesis-
-There is significant difference between the effect of Rasnasaptak Kwath and Vishwadi
kwath in Katigraha.
4 Introduction Vata, Pitta and Kapha are the three doshas mentioned in Ayurveda. These
tree doshas either vitiated or decreased causes the vydadhi. Vata, the one among the
three doshas is said to be superior most in all aspects as it affects the action and
movement of the other two doshas as well as all the dhatus etc. Vata is mainly present in
Pakvashay,KATI, sakthi,shrotra,asthi,sparshanendriyam.
5 Review of The literature for my dissertation will be reviwed from Ayurvedic classical textbooks,
Literature Modern textbooks and various recent and past researches andfrom internet.
- Keeriyoth Sajitha- A study on the effect of nature cure technique in the management
of katigraha; Govt. Ayurved college,Trivendrum, 1995
On Rasnasaptak Kwath
- Saha A.- A role of Rasna saptak kwath in amavata;1994
- Devi Poornima- Clinical study of amavata and its management by Ranasaptak
Kwath and indeginous compound;2002.
- Patil J S—The comparative study of individual and combined effect of Brihat
simhananda guggul and Rasna saptak kwath;2003
- A comparative study of mahaushadhadi kwath and rasnasaptak kwath on amavata
w.s.r. to rheumatoid arthritis;2015
5.2 Disease review- Katigraha is explained as separate disease in Ayurvedic classical
text ‘Gada Nigraha’. Katigrahais one of the 80 Nanatmaja Vatavyadhi mentioned by
Acharya Sharangadhara. None of Brihatrayee has explained Katigraha as a separate
entity. But a brief description of Katigraha as a disease with its Lakshana and Chikitsa is
available in Bhavaprakasha, Yogaratnakara and Vrindamadhava has given about the
same symptoms of Katigraha and describes its treatment in detail 5.
In Charaka Samhitha, Sushrutha Samhitha and Astanga Hrudaya, in Nanatamaja
Vata Vyadhi though Katigraha has not been mentioned, other symptoms of spinal diseases
like Prusthagraha, Trikagraha, Manyagraha etc are found, and also mentioned as a
symptom in some diseases.
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The following table shows the contents and the pramana of the drugs.
Ingredient Quantity
Rasna 1.part
Gokshur 1 part
Eranda 1 part
Devdaru 1 part
Punarnava 1 part
Amruta 1 part
aragvadh 1 part
shunthi prakshep
Following table shows the Karmukatva of the kwath.
Sr. Drug Latin Name Rasa Virya Vipak Guna
No.
1 Rasna Pluchea lanceolata Tikta Ushna Katu Guru
2 Eranda Ricinus communis Madhur Ushna Madhur Guru
Katu Snigdha
Kashay Tikshna
3 Devdaru Cedrus deodar Katu Ushna Katu Laghu
Tikta Snigdha
4 Punarnava Boerhavia diffusa Madhur Ushna Katu Laghu
Tikta Ruksha
5 Amruta Tinospora cordifolia Tikta Ushna Madhur Laghu
Kashay Snigdha
6 Aragvadh Cassia fistula Madhur Sheet Madhur Guru
Snigdha
7 Gokshur Tribulus terrestris Madhur Sheet Madhur Guru
Snigdha
8 Shunthi Zinziber officinale katu ushna Madhur Laghu
Snigdha
ÌuɵÉÉÌS YuÉÉjÉ
ÌuɵÉÉåÃoÉÔMüSvÉqÉÔsÉrÉuÉÉqpÉxÉÉ iÉÑ -
ÎuS¤ÉÉUÌWûÇaÉÑsÉuÉhɧÉrÉmÉÑwMüUÉhÉÉqÉç ||
cÉÔhÉïÇ ÌmÉoÉåiÉç ¾ûSrÉmÉɵÉïMüÌOûaÉëWûÉqÉ-
mÉYuÉÉvÉrÉÉÇxÉpÉ×vÉÃaÉeuÉUaÉÑsqÉvÉÑsÉÏ ||
(xÉWûx§ÉrÉÉåaÉ 1/500)
Ingredient Quantity
Vishwa 1 part
Eranda 1 part
Dashmoola 1 part
Yava 1 part
Kshardvaya Prakshep
(Sajjikshar,Yavaks
har), Hingu,
Lavanatray
(saindhav,
sauvarchal, beed),
pusharmool
choorna
Sr. Drug Latin Name Rasa Virya Vipak Guna
No.
1 Agnimantha Clerodendrum Katu Ushna Katu Laghu
phlomidis Tikta, Ruksha
Madhur
2 Shyonak Oroxylum indicum Madhur Ushna Katu Laghu
Tikta Ruksha
Kashay
3 Bruhati Solanum indicum Katu, Ushna Katu Laghu
Tikta Ruksha
4 Bilva Aegal marmelos Kashay, Ushna Katu Ruksha
Tikta Laghu
5 Patala Stereosprmum Tikta Anush Katu Laghu
sauvealens Kashay na Ruksha
6 Kantakari Solanum Tikta Ushna Katu Laghu
xanthocarpum Katu Ruksha
7 Gambhari Gmelia arborea Tikta Ushna Katu Guru
Kashay
Madhur
8 Shalaparni Desmodium Madhur Ushna Madhur Guru
gangeticum Tikta Snigdha
9 Prushniparni Uraria picta Madhur Ushna Madhur Laghu
Tikta Snigdha
10 Yava Hordeum vulgare Kashay Sheet Katu Ruksha
Madhur Laghu
11 Pushkarmula Inula racemosa Katu ushna katu Laghu
tikta tikshna
12 Hingu Ferula foetida katu ushna katu Laghu
Snigdha
tikshna
C) Collection And Standardization Of Drugs-
Authentication &identification of all raw materials will be done in Dept.of Dravyaguna &
Dept of Rasashstra and Bhaishajya Kalpana of our college
D) Preparation Of Drug-
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qÉ×imÉɧÉå YuÉÉjÉrÉåSè aÉëɽqÉ·qÉÉÇvÉÉuÉvÉåÌwÉiÉqÉç || 1 ||
iÉieÉsÉÇ mÉÉrÉrÉåkSÏqÉÉlMüÉåwhÉqÉç qÉײÎalÉxÉÉÍkÉiÉqÉç |
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(vÉÉ.xÉÇ.qÉ.ZÉÇ. 2/1,2)
E) Drug Administration-
7 Methodolog 7.1 Type Of Study Design- Randomized open comparative clinical study.
y
7.2 Location Of Study-
For this study subjects will be selected from O.P.D/I.P.D of our college
Duration of administration of drug- 60 days, follow up on 15th, 30th, 45th & 60th day.
Total duration of study and observation- 18 months
b)Exclusion Criteria-
1. Patients With known case of low backache due to any
infection,cancerous,congenital,vascular diseases.
2. Patients associated with any known case of other systemic disorder.
3. Pregnant or lactating women.
4. Patients not willing for trial.
A) Gradation of Parameters
Subjective Parameters
B Mild pain 1
Occasional pain, can be managed
without the drug
C Moderate 2
Frequent pain, can be managed with
drug
D Severe 3
Persistent pain, unmanagable with
drug
2. Katigraha-
Sr. Description Grade
A No stiffness 0
B Mild stiffness 1
Occasional stiffness, can be managed
without the drug
C Moderate stiffness 2
Frequent stiffness, can be managed with
drug
D Severe stiffness 3
Persistent stiffness, unmanageable with
drug
Objective parameters-
Sr. Description Grade
3. SLR Test-
A More than 90 0
B 61-90 1
C 31-60 2
D Upto 30 3
4. Walking time-
Time taken by the patient to walk a distance of 100 meters is noted.
A Excellent 0
B Moderately 1
improved
C Mildly improved 2
D Not improved 3
5. Tenderness -
Sr. Description Grade
A No tenderness 0
B Tender but 1
bearable
C Tender and winced 2
Follow up-
Sr. no Symptom/ Day 0 Day 15 Day 30 Day 45 Day 60
Sign
1 Katishoola
2 Katigraha
3 SLR
4 Walking
Time
5 Tenderness
The sample size for present study will be 60. Further those patients will be matched and
divided into two equal groups viz. group A & group B.
Data will be collected with the help of history taking,physical examination of the patients. It
will be done at day 0 and at every follow up and will be noted in follow up table.
Collected data will be presented in the form of graphs, tables and charts.
Wilcoxon signed rank test will be used for efficacy of drugs at 5% level of
significance.
For comparative study of drugs Mann Whitney ‘U’ test will be applied at 5%
level of significance. Other suitable test will be applied whenever necessary.
Withdrawal Criteria-
Results and inference will be drawn on the basis of readings obtained before and after
treatment by using statistical methods.
8.9 Conclusion-
Final conclusion will be drawn on the basis of statistical analysis with overall assessment.
8.10 Summery-
9 Reference
- Dr. Anna Moreshwar Kunte & Pandit Krushnashastrinavare Edited By Pandit Hari
Sadashiv Shastri Paradkar Ashtanghridaya Of Vagbhata With Sarvangasundar Of
Arundatta & Ayurvedarasayana Of Hemadri Sutrasthan Adhyay 1 Ayushkamiya
adhyaya Verse 6,7 Chaukhamba Sanskrit Sansthan Varanasi Page No 6,7
- Dr. Shuvkumar Mishra, Dr. V. Pandirtav & Dr. Sharada Nair Hindi Commentary
Edited By Vaidya Mahendrapal Sing Aarya Sahastrayogam Purvardha Chapter 1
Kashay Prakaran Verse 500 vandmay Anusandhan Ekak Page No-101
- Dr. Anna Moreshwar Kunte & Pandit Krushnashastrinavare Edited By Pandit Hari
Sadashiv Shastri Paradkar Ashtanghridaya Of Vagbhata With Sarvangasundar Of
Arundatta & Ayurvedarasayana Of Hemadri Sutrasthan Adhyay 13
Doshopakramaniya adhyaya Verse 1-3, Chaukhamba Sanskrit Sansthan Varanasi
Page No 211
- Dr. Anna Moreshwar Kunte & Pandit Krushnashastrinavare Edited By Pandit Hari
Sadashiv Shastri Paradkar Ashtanghridaya Of Vagbhata With Sarvangasundar Of
Arundatta & Ayurvedarasayana Of Hemadri Sutrasthan Adhyay 13
Doshopakramaniya adhyaya Verse 37-39, Chaukhamba Sanskrit Sansthan
Varanasi Page No 218,219
- Pt. Shri Umeshananda Sharma & Pt. Brahma Shankar Shastri Madhava Nidana Of
Shri Madhavakar With Sudhalahari Comments Adhyaya 22 Vatavyadhi Nidan Verse
14 Choukhambaa Sanskrit Prakashan 1943 Page No. 98
- Vaidya Yadavji Trikamji Acharya & Prof.R.H. Singh Charak Samhita of Agnivesa
Elaborated by Charaka & Dridhabala Commentary by Shri Chakrapanidatta
Chikitsasthan Adhyay 28 Vatavyadhi Chikitsa Verse 87-88, Chaukhamba Surbharti
Prakashan Varanasi Page no.620,621
- Vaidya Jadavji Trikamji Acharya & Narayan Ram Acharya Sushruta Samhita Of
Sushruta With Nibandhasangraha Commentary of Shri Dalhanacharya Nidansthan
Adhyay 1 Vatavyadhinidan Verse 23-24 Chaukhamba Surbharati Prakashan
Vranasi Page No. 261
i) ABBREVIATIONS-
1) A. û¾- A¹É…¡û¾ûSrÉ
2) aÉ. ÌlÉ- aÉSÌlÉaÉëW
3)û zÉÉ. xÉÇ - zÉÉ…¡ïûkÉU xÉÇÌWûiÉÉ
4) xÉÔ- xÉÔ§ÉxjÉÉlÉ
5) qÉ.ZÉÇ.- qÉkrÉqÉ ZÉÇQû
ii)CASE PROFORMA
Medical-
Surgical-
Family history-
Swa kula-
Matru kule-
Pitru kula-
Personal history-
Diet:
Nidra:
Vyasan:
Emotional stress:
General examination-
Pulse- Jivha-
BP- Netra
RR- Nakha-
Agni- Twak-
Koshta- Mala- Mutra
PRAKRUTI PARIKSHAN-
Rup Varna Agni ahar cheshta nidra vani buddhi satava Svabha
a v
Vata
Pitta
kapha
Prakruti vishesh-
EXAMINATION OF INDRIYA-
Dnyanendriya- Karmendriya-
Shrotendriya- Hasta-
Sparshanendriya- Pada-
Chakshunendriya- Guda-
Rasanendriya- Upashta-
Ghranendriya- Vaak-
STROTAS PARIKSHAN-
Pranavahastrotas-
Annavahastrotas-
Udakvahastrotas-
Rasavahastrotas-
Raktavahastrotas-
Mansavahastrotas-
Medovahastrotas-
Asthivahastrotas-
Majjavahastrotas-
Shukravahastrotas-
Aartavavahastrotas-
Purishvahastrotas-
Mutravahastrotas-
Swedavahastrotas-
Examination-
G.C-
Temp-
Pulse-
B.P.-
R.S.-
CVS-
Nidan panchak-
Hetu-
Purvarupa-
Lakshana-
Upashaya-
Samprapti-
Strotas-
Adhisthan-
Vyadhivastha-
Parametric assessment
Schedule of treatment-
Group-
Administration of drug-
Duration 60 days starting- / / end- / /
iii)Drug preparation method
1) LMüÉ mÉÉiÉåsrÉÉiÉ ÌSsÉåsÉå AÉæwÉkÉ 20 aÉëäqÉ bÉåFlÉ irÉÉqÉkrÉå 320 ÍqÉ.ÍsÉ. mÉÉhÉÏ bÉÉsÉÉuÉå.
2) lÉÇiÉU iÉå mÉÉiÉåsÉå aÉäxÉ qÉÇS AÉcÉåuÉU PåûFlÉ 40 ÍqÉ.ÍsÉ. ÍvÉssÉMü UÉWûÏsÉ iÉÉå mÉrÉïÇiÉ MüÉRûÉ EMüVûÉuÉÉ.
qÉɧÉÉ - 40 ÍqÉ.ÍsÉ.
Annexure 2-
CONSENT FORM
CERTIFICATE BY INVESTIGATOR
I certify that I have disclosed all details about the study in the terms easily understood by
the patient.
Date-
Signature Of The Subject
Consent by subject
Name-
Age-
I, exercising me free power of choice, hereby give my consent to be
included as a subject in the clinical validation of Rasnasaptak kwath &Vishwadi kwath in
Katigraha.
The attending physician the purpose of the clinical trial & the nature of drug treatment
&following have informed me to my satisfaction, including the investigations to be
performed to monitor &safeguard my body functions.
I am also aware of my right to opt out of the trial at any time during the course of
the train without having to give the reasons for doing so. I am willing to undergo any risk
for inclusion in this study.
Date:
Signature/thumb impression
Date: Name of the witness
Signature/thumb impression
Relationship
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