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biotechnological interest ever since Gary toxicity, there was 50–70% reduction in Azevedo, J. L., Genet. Mol. Biol., 2002,.
Strobel and his team described a func- transpiration through the leaves. Endo- 25, 251–255.
tionalized diterpenoied and the famed phytic colonization strategy had earlier 6. Suryanarayanan, T. S. and Kumaresan,
V., Mycol. Res., 2000, 104, 1465–1467.
anticancer agent paclitaxel, from species been attempted with the biocontrol bacte-
7. Suryanarayanan, T. S., Ravishankar, J. P,
of Taxus across the globe9–11. A novel rium Bacillus subtilis BB for vegetable Venkatesan, G. and Murali, T. S., Mycol.
fungus Taxomyces andreanae was recovered brassicas following seed inoculation15. Res., 2004, 108, 1–5.
from Taxus brevifolia, which also pro- Endophytic habitat appears to provide 8. Girivasan, K. P. and Suryanarayanan, T.
duced paclitaxel. With these beginnings, a protective environment that helps a po- S., Czech. Mycol., 2004, 56, 33–43.
endophytic, bacterial and fungal diversity tentially exploitable bacterium with re- 9. Strobel, G. A. and Long, D., ASM News,
has been extensively screened for antibio- duced competition from the indigenous 1998, 64, 263–268.
tics, antivirals and anticancer agents, as anti- microbial populations. In view of their 10. Strobel, G. A., Ford, E., Li, J. Y., Sears,
J., Sidhu, R. S. and Hess, W. M., Syst.
oxidants, anti-insecticidal activity, and widespread application in plant and hu-
Appl. Microbiol., 1999, 22, 426–433.
antidiabetic and anti-immunosuppressive man health and environment, concerted 11. Shreshtha, K., Strobel, G. A., Prakash, S.
compounds, etc.12,13. efforts at endophytic diversity searches and Gewali, M., Planta Med., 2001, 67,
While antimicrobial and anticancerous coupled with exploitation are necessary 374–376.
searches continue with renewed vigour, in the country on account of the varied 12. Strobel, G. A., Crit. Rev. Biotechnol.,
novel technologies based on endophytic and rich plant diversity. 2002, 22, 315–333.
bacteria have recently emerged on the 13. Strobel, G. and Daisy, B., Microbiol.
scene. Barc et al.14 have utilized genetically Mol. Biol. Rev., 2003, 67, 491–502.
1. Clay, K. and Holah, J., Science, 1999, 14. Barc, T. et al., Nature Biotechnol., 2004,
engineered endophytic bacterium, Bur- 285, 1742–1744. 22, 583–588.
kholderia cepacia for phytoremediation 2. Redman, R. S., Sheehan, K. B., Stout, R. 15. Wuelff, E. G., van Vuurdes, J. W. L. and
of water-soluble and volatile organic pol- G., Rodriguez, R. J. and Henson, J. M., Hockenhull, J., Plant Soil, 2003, 255,
lutants such as toluene. This was achieved Science, 2002, 298, 1581. 463–474.
through the introduction pTOM plasmid 3. Arnold, A. E., Meffa, L. C., Kyollo, D.,
of B. cepacia G4 into the natural bacterial Rojas, E. I., Maynard, Z., Robbins, N.
and Herre, E. A., Proc. Natl. Acad. Sci.
endophyte of the yellow lupine (B. cepa-
USA, 2003, 100, 15649–15654.
cia L. S. 2.4), and introduction of the 4. Ganley, R. J., Brunsfeld, S. J. and New- Bhavdish N. Johri is in the Department of
modified strain (B. cepacia VM 1330) combe, G., Proc. Natl. Acad. Sci. USA, Biotechnology and Bioinformatics Centre,
into surface-sterilized seeds. Besides con- 2004, 101, 10107–10112. Barkatullah University, Bhopal 462 026,
siderable degradation of toluene which 5. Glienke-Blanco, C., Aguilar-Vildoso, C. I., India.
resulted in marked reduction of phyto- Vieira, M. L. C., Barroso, P. A. V. and e-mail: bhavdishnjohri@rediffmail.com
The Indo-US Agreement of 18 July 2005 approve the legislation, may include (NNWS). Initially, the NPT was conceived
and the subsequent agreement of 2 March some additional conditions that India would to deny the countries that launched the
2006, following the visit of President have to accept. The Indian Government’s second world war, namely Germany,
Bush to India, have been discussed exten- position is that it stands by the agree- Japan and Italy permanently of the ability
sively in the Indian and US media for the ments of 18 July 2005 and 2 March 2006 to make nuclear weapons. As it turned
past ten months. At present, the US Con- and that no new conditions would be ac- out, the NPT legitimized USA, USSR,
gress is holding hearings on the proposed ceptable to the Government. the UK, France and China as NWS (inci-
legislation to enable the US to enter into To understand the whole gamut of issues dentally, the same five states are also the
civil nuclear energy cooperation with India involved, it is important to recall the back- five permanent members of the United Na-
and to allow the US administration to ground to the 18 July 2005 agreement. tions Security Council with veto powers)
approach the nuclear suppliers’ group to This agreement itself sought to redress and required other states to give up their
adjust its policies to make an exception the anomalous situation India enjoyed in rights to acquire nuclear weapons for all
in the case of India. We shall certainly be the global non-proliferation regime. India times.
hearing of both support and opposition refused to join the nuclear non-prolife- India termed the NPT discriminatory
from various Senators and Congressmen. ration treaty (NPT), which came into be- and refused to join it from the very be-
As of now it is not clear if the US Con- ing in 1968, at the initiative of USA, ginning. Pakistan, although receiving
gress will accord its approval before the USSR and the UK. The NPT defined a cut- substantial military and economic assis-
June or July deadline. There will be a re- off date of 1 January 1967 and recog- tance from USA, also refused to join the
cess thereafter and on reconvening, the nized those countries which had carried NPT, on the ground that India had chosen
US Congress is expected to be busy with out a nuclear test prior to that date as nu- to keep itself out of it. Israel also kept
new elections. There is also a possibility clear weapon states (NWS), and all other itself out of the NPT and managed to build
that the US Congress, even if it were to countries as non-nuclear weapon states up a nuclear weapon capability during