The Promise of Stem Cells Fulfilled

White Paper

2019 TotiMed Group International Inc.

 -CHANGE IN THE TREATMENT OF HUMAN DISEASES

Minimally invasive adult telomerase-

positive stem cell therapy now a
reality

Overview

A breakthrough more than 40 years in the making now allows patients

suffering from a myriad of degenerative diseases the ability to heal
themselves using their own stem cells.

What was once deemed impossible by the medical community, is now not only
possible, but has been proven to be safe and effective in a multitude of cases by
patients utilizing a new ‘designer’ protocol that combines a patient-specific
nutraceutical program with a patented, minimally invasive stem cell treatment
process.

Key Takeaways
• ‘Designer’ adult stem cell therapy for treatment of human
diseases is now a viable option for patients

• Patented method uses a patient's own telomerase-positive

stem cells

• New therapy is minimally invasive and proven to be efficacious

and safe

2019 TGI, Inc. Private & confidential

Background

The body contains trillions of cells. These cells can be divided into three
basic groups:

1. Functional Cells
2. Maintenance Cells
3. Healing Cells

Functional cells comprise the majority of the 220 cell types of the body. They are
telomerase-negative and thus have a defined life-span before they are genetically
pre-programmed to age and die. Functional cells comprise 50% of all cells of the
body and are located within specific organs and tissues throughout the body.

Maintenance cells support the functional cells on a day to day basis. As functional
cells wear out and die, the maintenance cells proliferate, differentiate, and assume
the function of the worn out and dead functional cells. Maintenance cells are
telomerase-negative and thus have a defined lifespan before they are genetically
preprogrammed to senesce and die. Maintenance cells comprise 40% of all cells of
the body and are located within specific organs and tissues throughout the body.

2019 TGI, Inc. Private & confidential

Background Continued

Healing cells are normally dormant and can be found hibernating within the
stromal connective tissues (niches) throughout the body. Their function is to
replace functional cells and maintenance cells lost due to trauma and/or disease.
Healing cells are telomerase- positive, and thus have essentially an unlimited
lifespan before they become maintenance cells and/or functional cells. Numbers of
dormant healing cells remain relatively constant throughout the lifespan of the
individual at approximately 10%.

Examples and percentages within the body of healing, telomerase- positive cells
are Pluripotent Stem Cells ~ 0.9%; and Totipotent Stem Cells ~0.1%.

Totipotent Stem Cells will differentiate into ALL cells within the body.

Pluripotent Stem Cells will differentiate into all cells of the body, EXCEPT nucleus
pulposus of IVD and derivatives of spermatogonia and oogonia.

will differentiate into ALL cells within

the body, thus allowing one’s own body to essentially heal
itself.”

2019 TGI, Inc. Private & confidential

A Groundbreaking Discovery

Dr. Henry Young, PhD discovered telomerase-positive

cells (totipotent and pluripotent) 43 years ago; cells that can
be isolated, harvested and activated to treat diseases when
reintroduced or transplanted back into the recipient.

Dr. Young spent the first 30+ years after his initial discovery
understanding all aspects of these cells and developing animal
models for treatment of diseases.

Since 2006, Dr. Young has applied that knowledge to create a novel stem cell-based
therapy for the treatment of human diseases using an adult patient’s own telomerase-
positive cells.

2019 TGI, Inc. Private & confidential

A New Option for Patients

In 2018, Totimed Group International, Inc. (TGI) was formed to help bring
Dr. Young’s work to patients around the globe.

With the help of a nationally-renowned medical staff in Charlotte, North Carolina led by
Dr. Neil Speight, Dr. Young’s groundbreaking discovery and subsequent, patented
treatment model, now known as Designer & Healing Stem Cell Therapy™, is now being
offered to patients as a minimally invasive procedure for the treatment of a wide array of
diseases, including but not limited to:

lzheimer’s Disease
• Amyotrophic Lateral Sclerosis (ALS)
• Blindness
• Dementia
• Macular Degeneration
• Multiple Sclerosis (MS)
• Neuropathies
• Sciatica
• Stroke
• Traumatic Brain Injury (TBI)
• Traumatic Spinal Cord Injury

2019 TGI, Inc. Private & confidential

 Unique, Safe & Effective

t the heart of TGI’s patented stem cell therapy is totipotent stem cells,
known as the ‘master’ cells of the body because they have the capacity to
differentiate into the 220 specialized cell types that comprise the human
body.

TGI’s totipotent stem cells are unique to TGI’s identification, harvest,

activation and transplantation method in that they:

Fully developed human stem cell including a full

organism

• Have the ability to replicate in unlimited numbers

without losing their total potency

• Are isolated by simple blood draw filtration or by in-

Vivo utilizing one’s own body as a bioreactor to
proliferate TSC

• Do not produce teratomas (cancerous tumors)

2019 TGI, Inc. Private & confidential

Science & Nature Combined

Like vegetables in a garden, stem cells need fertile soil to yield optimal results. So, in a
world where studies show 8 out of 10 adults in the U.S. have a poor diet that lacks the
nutrients required for successful stem cell therapy, TGI teamed up with world renowned
nutritionist and ‘Superfood Hunter’ Darin Olien to create proprietary nutraceutical
products for patients going through TGI’s Designer & Healing Stem Cell Therapy™.

“Olien is the ‘Indiana Jones’

of superfoods͙”

2019 TGI, Inc. Private & confidential

 Protocol
#1: Day 1
Patient Intake
Patient Follow-
Up: Assessment of
Condition
6, 12, 24, 36 (Physical, blood
months
work for labs,
imaging &
diagnosis)
#2: Pre-
Treatment
#6 Repeat 60 days of
nutraceutical
Steps 3, 4 & 5 as
program prior to
needed
stem cell
solation

#5 Change to Day
60 #3: 30-60 Days
Assessment of Patient Prep
condition of patient: 1. 3 days restricted
Physical, blood work activity
for labs, function 2. Hydration
tests, imaging, well- 3. Blood Draw
being survey #4 Patient-Re-
4. Isolate Stem Cells
Insertion
5. Activate Stem Cells
*TpSC’s
separated/combin
ed based on
treatment protocol

*Telomerase-positive adult stem cells (TpSC’s)

2019 TGI, Inc. Private & confidential

Results

snapshot of success for enhanced patient outcomes utilizing TGI’s Designer

& Healing Stem Cell Therapy™

Partial vision restoration in multiple sclerosis

• Improved ejection fraction of over 25% post heart attack

• Resolution of debilitating angina in severe cardiovascular

disease

• Greater than 50% reduction in pain and significant improvement

in mobility after traumatic knee injuries

2019 TGI, Inc. Private & confidential

About Us

Totimed Group International, Inc. combines the power of science with nature to
give patients and healthcare providers cross the globe access to next gen medical methods
and innovations that drive healthier patient outcomes.

Healthier living driven by the power of science & nature™

2019 TGI, Inc. Private & confidential

Dr. Henry Young, PhD is credited with a number of achievements throughout his career that spans more than three
decades. In his work, he has contributed to the research surrounding tissue regeneration and stem cell biology.
Furthermore, Dr. Young has aided in the invention of muscle morphogenetic protein and scar inhibitory factor. He
discovered the adult germ layer lineage stem cells, adult mesodermal stem cells, adult pluripotent stem cells and adult
totipotent stem cells.

Dr. Young’s interest in science started at a young age. He pursued the field first at Ohio State University, earning a Bachelor
of Science in biology in 1974. Following this, he continued at the University of Arkansas to receive an MSc in zoology. In
1983, Dr. Young received a PhD from Texas Tech University. He remained dedicated to his academic development with
postdoctoral work in carbohydrate biochemistry at Case Western Reserve University and as a postdoctoral fellow of the
Muscular Dystrophy Association, Inc. In 1987, Dr. Young became an instructor of biochemistry at Rush University Medical
Center (formerly Rush-Presbyterian- St. Luke’s Medical Center). In 1988, he joined the faculty at Mercer University as an
assistant professor of surgery, assistant professor of anatomy. In 1995, he became an associate professor of pediatrics and
associate professor of anatomy at the institution.

He remained in these positions until 2004, where he then came on board as a professor of pediatrics at the university. From
2007 to 2012, Dr. Young continued preparing the future generation of medical professionals as a professor of obstetrics and
gynecology. This was joined by the position of professor of anesthesiology. His latest position with the university was as a
professor of anatomy, which he held until 2015. Dr. Young has also recently been editor-in-chief of the Journal of Stem Cell
Research.

His longstanding quality work efforts have resulted in being chosen as the Chief Science Officer of Dragonfly Foundation for
Research & Development. Dragonfly Foundation and Research Designs LLC are performing clinical trials using his
endogenous adult stem cell technologies.

On top of receiving numerous awards and accolades for his work, Dr. Young has established himself professional with the
help of affiliations to various organizations. He has aligned himself with the International Cellular Medicine Society, The
American Society for Cell Biology, Stem Cells and Regenerative Medicine, the Tissue Culture Society, the American
Association of Anatomists, Arnold P. Gold Foundation and the Humanism Honor Society.

2019 TGI, Inc. Private & confidential

Dr. Neal Speight obtained his undergraduate work in chemistry at University of North Carolina-Chapel Hill. He attended
medical school at East Carolina School of Medicine and completed his residency at University of South Carolina-
Columbia.

He is board certified in Family Medicine and has additional training in Metal Toxicology, Nutritional, and Environmental
Medicine. He is a member of the American Academy of Environmental Medicine and is the Past President of The
American College for the Advancement of Medicine (ACAM). For five years he served as an assistant professor at Capitol
University of Integrative Medicine in Washington, DC and has authored several book chapters and a number of articles in
the peer reviewed literature.

Known as the “Indiana Jones of Superfoods,” Darin Olien has partnered with TotiMed to develop unique and proprietary plant based
nutrients to supplement the stems cell growth. Darin is the first ever health and wellness expert to be coined a “Superfood
Hunter.” He is known uniquely within the health and wellness community as an exotic superfood expert, supplement formulator, and
environmental activist who travels the planet to discover new and underutilized medicinal plants.

Inspired by his travels around the world, he has created an individualized approach to achieving optimal health through small changes
and daily habits based on the wisdom of global cultures. It’s his no-judgment, progress-focused, supportive approach that gets results.

Darin’s interest in food and nutrition began when a college football injury drove him to uncover better ways to heal his body. He
realized there had to be a better option out thereafter he struggled to recover using only traditional Western medicine treatments that
failed to address the healing potential of his diet and lifestyle choices. It’s then that he began to pursue a healthier lifestyle and deeper
understanding of how hydration, nutrition, and exercise can truly impact the human body. Darin changed his major, studying Exercise
Physiology and Nutrition. He now holds a Bachelor degree in this field as well as a Masters in Psychology.

Today, Darin is widely recognized as an authority and valuable resource on plant-based nutrition, supplement formulation and elite
performance programs, which he has created for some of the top athletes in the world.

2019 TGI, Inc. Private & confidential

TGI donates 30% of annual profits to the Charlotte Foundation for Molecular
Medicine to help patients pay for exceptional care.

Charlotte Foundation for

Molecular Medicine

The Charlotte Foundation for Molecular Medicine

1258 Mann Drive, Suite 100
Matthews, NC 28105

03
2019 TGI, Inc. Private & confidential
Appendix
Neurogenic diseases treated by TGI’s Designer & Healing Stem Cell Therapy™
lzheimer’s Disease - donor (allogeneic) TSCs from individuals with family histories absent of lzheimer’s disease could
reverse symptoms in individuals with lzheimer’s disease for a period of two months before next transplant. We were able to
sustain lzheimer’s-free status through at least six treatments.

Amyotrophic Lateral Sclerosis (ALS) - both autologous and allogeneic TSCs could reverse symptoms of disease for a period of
two to four weeks post-transplant. Unfortunately, do to logistics could only transplant once every eight weeks. Currently
assessing capability to expand TSCs ex vivo to shorten time frame between transplants.

Blindness - autologous TSCs could incrementally reverse total blindness to visualizing shades of gray through multiple
treatments in compliant individuals.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - autologous TSCs could reverse symptoms of disease for a
period of two months post-transplant. We were able to sustain CIDP-free status through at least six treatments in compliant
individuals.

Dementia - autologous TSCs could reverse symptoms of dementia for a period of six months post-transplant in compliant
individuals.

Macular Degeneration - autologous TSCs could reverse symptoms of disease in compliant individuals without co-morbidities

Multiple Sclerosis (MS) - autologous TSCs could reverse symptoms of disease for a period of two to six months post-
transplant. We were able to sustain increasing step-wise reversal of symptoms through six treatments in compliant individuals.

Neuropathies - autologous and/or allogeneic TSCs could reverse symptoms of disease for a period up to two months post-
transplants in compliant individuals. We were able to sustain reversal of symptoms through three years and counting in compliant
individuals.

Sciatica - autologous and/or allogeneic TSCs could reverse symptoms of Sciatica for a period of two to six months post-transplant
in compliant individuals.

Stroke - autologous TSCs could incrementally reverse long standing symptoms of stroke, depending on number of treatments
given in compliant individuals.

Traumatic Brain Injury (TBI) - autologous TSCs in combination with hyperbaric oxygen could reverse symptoms of TBI in
compliant individuals.

Traumatic Spinal Cord Injury (TSCI) - autologous TSCs could incrementally and permanently reverse paraplegic symptoms of TSCI
in compliant individuals. One paraplegic individual had bladder/bowel function restored after two autologous stem cell
treatments.

2019 TGI, Inc. Private & confidential

 References
Black et al. From Bench Top to Bedside: Formation of Pulmonary Alveolar Epithelial Cells by Maintenance Cells and Healing Cells. J Stem Cell Res. 2017; 1(2) 002: 1-16.
Centeno et al. ICMS Stem Cell Lab Practices Guidelines, Version 1.0, 18 pgs, © 2009, The International Cellular Medicine Society. (Invited)

Dixon et al. Recombinant human bone morphogenetic proteins-2 and 4 (rhBMP-2 and rhBMP-4) induce several mesenchymal phenotypes in culture. Wound Repair and
Regeneration 4:374-380, 1996.

Lucas et al. A population of cells resident within embryonic and newborn rat skeletal muscle is capable of differentiating into multiple mesodermal phenotypes. Wound
Repair and Regeneration 3:449-460, 1995.

McCommon et al. Primitive adult-derived stem cells are present in the blood of adult equines and can be increased in number with moderate exercise or ingestion of a
cyanobacter, Aphanizomenon flos-aquae. Autocoids 2: 103, 2013.

Mignon et al. Transplantation of multipotent cells extracted from adult skeletal muscles into the adult subventricular zone of adult rats. J Comp Neurol 491:96-108, 2005.

Rogers et al. Differentiation factors induce expression of muscle, fat, cartilage, and bone in a clone of mouse pluripotent mesenchymal stem cells. The American Surgeon
61(3):231-236, 1995.

Pate et al. Isolation and differentiation of mesenchymal stem cells from rabbit muscle. Surgical Forum, XLIV:587-589,1993.

Romero-Ramos et al. Neuronal differentiation of stem cells isolated from adult muscle. J Neurosci Res 69:894-907, 2002.

Seruya et al. Clonal Population of adult stem cells: life span and differentiation potential. Cell Transplant 13:93-101, 2004

Stout et al. Primitive stem cells reside in adult swine skeletal muscle and are mobilized into the peripheral blood following trauma. American Surgeon 73 (11):1106-1110,
2007.

Stout et al. Discovery of pluripotent and totipotent stem cells in the heart of the adult rat. Amer Surg 73:S63, 2007.

Vourc'h et al. Isolation and characterization of cells with neurogenic potential from adult skeletal muscle. Biochemical and Biophysical Research Communications 317:893-
901, 2004.

Vourc’h et al. Effect of neurturin on multipotent cells isolated from the adult skeletal muscle. Biochem Biophys Res Commun 332:215-223, 2005.

Warejcka et al. A population of cells isolated from rat heart capable of differentiating into several mesodermal phenotypes. J. Surg. Res. 62:233-242, 1996.

Young. Epidermal ridge formation during limb regeneration in the adult salamander, Ambystoma annulatum. Proceedings of the Arkansas Academy of Science, 31:107-109,
1977.

Young HE, Bailey CF, Dalley BK. Environmental conditions prerequisite for complete limb regeneration in the postmetamorphic adult land- phase salamander, Ambystoma.
Anatomical Record, 206:289-294, 1983.

Young et al. Gross morphological analysis of limb regeneration in postmetamorphic adult Ambystoma. Anatomical Record, 206:295-306, 1983.

Young et al. Identification of hyaluronate within peripheral nervous tissue matrices during limb regeneration. Edited by Coates, P.W., Markwald, R.R., Kenny, A.D., Alan R.
Liss, Inc., New York. In: Developing and Regenerating Vertebrate Nervous Systems, Neurology and Neurobiology, 6:175-183, 1983.

Young et al. Histological analysis of limb regeneration in postmetamorphic adult Ambystoma. Anatomical Record, 212:183-194, 1985.

Young et al. Initial characterization of small proteoglycans synthesized by embryonic chick leg muscle-associated connective tissues. Connective Tissue Research, 17:99-118,
1988.

Young et al. Effect of selected denervations on glycoconjugate composition and tissue morphology during the initiation phase of limb regeneration in adult Ambystoma.
Anatomical Record, 223:223-230, 1989.

Young et al. Glycoconjugates in normal wound tissue matrices during the initiation phase of limb regeneration in adult Ambystoma. Anatomical Record, 223:231-241, 1989.

Young et al. Histochemical analysis of newly synthesized and resident sulfated glycosaminoglycans during musculogenesis in the embryonic chick leg. Journal of
Morphology, 201:85-103, 1989.

Young et al. Changes in synthesis of sulfated glycoconjugates during muscle development, maturation, and aging in embryonic to senescent CBF-1 mouse. Mechanisms of
Ageing and Development, 53:179-193, 1990.

Young et al. Cryopreservation of embryonic chick myogenic lineage-committed stem cells. Journal of Tissue Culture Methods, 13:275-284, 1991.

Young et al. Enzyme-linked immuno-culture assay. Journal of Tissue Culture Methods, 14:31-36, 1992.

Young et al. Isolation of embryonic chick myosatellite and pluripotent stem cells. Journal of Tissue Culture Methods, 14:85-92, 1992.

2019 TGI, Inc. Private & confidential

 TM

Totimed Group International, Inc.

Marc S. Nehamkin, Managing Partner
408-202-3931
E-mail: MarcN@Totimed.com
 Monitoring Patients During Treatment
End of FU FU
Pre-Rx Wk 2# Wk 4
Rx Wk 12 Wk 48

Clinic visit X X X

HCV RNA X X X X X

CBC X X X X X X

Liver panel X X X X X X

Cr/INR X X+ X+

+Optional, to consider in cirrhotics

#For patients receiving RBV, Viekira Pak or Techivie
Baseline assessment

Below͙͙ . bove
Other factors
Lab Tests
 PRESENTATION MEGA PACK
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 MEDICAL
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INGREDIENTS

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Health Care
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