Abstracts - Aspire: ART Paving the way for new frontiers
AC-019
Correlation between endometrial thickness, triple line
pattern and blood flow, and combinations of these
parameters, with successful pregnancy outcome in an IVF
programme
Djuwantono T, Permadi W, Chandra R, Rifayani S, Harlianto H
Aster Fertility Clinic, Hasan Sadikin Hospital, Indonesia
djuwantono@yahoo.com
Introduction: The successful rate of IVF programme is still
pretty much unfavourable as it depends on the endometrial
receptivity and until this present moment there are still no
known gold standard evaluation criteria.
Materials/Methods: an analytic correlation prospective
cohort study was conducted on women who participated in IVF
programme at Aster Fertility Clinic, Dr Hasan Sadikin General
Hospital, Bandung.
Results: This study has been conducted on 73 women, and
the confirmed clinical pregnancy rate was 38.4%, with mean
age of 35 years (4.76) and infertility history time frame was
6.4 years (3.37). The cut-off point of endometrial thickness
was 9.2 mm. Cases with endometrial thickness of ≥9.2 mm
found in 83.6% of cases with 45% successful pregnancy rate
and a possibility of 37%, while for those of ≤9.2 mm, they
were 16.4%, 7.7%, and 37%, respectively. The triple line as
well as blood flow patterns were detected in 76.7% and 50.7%
of cases with mean pregnancy outcome of 48.2% and 64.9%,
while the chances were 37% and 33% respectively. The most
influential factors on a successful pregnancy outcome were, in
order, endometrial blood flow pattern (OR = 9.31, P = 0.001),
endometrial thickness (OR = 7.89) and triple line pattern of the
endometrium (OR = 5.16). The chance of clinical pregnancy
with all these three parameters in combination were 71.5%.
Conclusions: There was a significant correlation between
the endometrial thickness, triple line pattern and endometrial
blood flow with outcome of successful pregnancy rate. The
combination of these three parameters could predict the
outcome of clinical pregnancy rate even better.
AC-020
Differences between day-2 and day-3 embryo transfer
following ovum retrieval procedure and factors
influencing successful outcomes in an IVF programme
Harlianto H, Djuwantono T, Permadi W, Konstantine V,
Nataprawira D
Aster Fertility Clinic–Hasan Sadikin Hospital, Indonesia
harrisharlianto@yahoo.com
Introduction: Embryo day transfer still based on the number
of fertilization. But the influence of embryo transfer on day 2
or day 3, or the effect of factors contributing to the pregnancy
rate, such as number of oocytes, total embryo quality score,
difficult transfer techniques, and blood/mucus contamination on
catheter, on the successful pregnancy outcome rate are not well
known. Even the most influential factor is not being explored
yet. The aim of the study was to know the difference of day-2
and day-3 embryo transfer in accordance to pregnancy rate, to
know the effect of factors and decide the dominant factor.
Materials/Methods: This study was an experimental
laboratory research with prospective approach conducted to
women that enrolled to an IVF programme in Aster Fertility
Clinic, Hasan Sadikin Hospital Bandung from October 2006
to October 2007.
Reproductive BioMedicine Online, Vol. 16, Suppl. 2, April 2008
Result: This study has been conducted to 65 women, with
mean age for day-2 transfer of 35.24 years (SD = 5.48) and
for day-3 transfer 34.42 years (SD = 3.11). Mean infertility
period for day-2 transfer was 6.72 years (SD = 3.26) and for
day-3 transfer 6.16 years (SD = 3.17). The study found an
higher rate of pregnancy outcome for day-3 transfer (63.2%)
compared with day-2 transfer (30.4%). Factors that have an
effect on successful pregnancy rate were number of oocytes
(P = 0.003), embryo quality score (P = 0.001), while factors
which did not were difficult transfer techniques (P = 1.00), and
blood/mucus contamination on catheter (P = 1.00). According
to double logistic regression analysis, total embryo score was
the most reliable predictor to successful post-ovum retrieval
pregnancy rate (OR = 2.104, CI = 0.592–64.380).
Conclusions: The day-3 embryo transfer showed an increase in
pregnancy outcome rate. Factors such as increasing number of
oocytes, embryo quality total score have effect on the increase
of pregnancy outcome rate, while difficult transfer techniques
and blood/mucus contamination on catheter do not. The most
dominant factor is embryo quality score.
AC-021
Effect of two different courses of ultralong down-
regulation with gonadotrophin-releasing hormone agonist
depot on outcome of IVF in stage III/IV endometriosis
Halim B, Lutan D, Tanjung MT
Halim Fertility Center, Dept O and G, USU, Indonesia
binarwan2002@yahoo.com
Introduction: To compare the effect of 3-month and 6-month
courses of gonadotrophin-releasing hormone (GnRH) agonist
depot for ultralong down-regulation on outcome of IVF.
Materials/Methods: Twenty-nine patients with stage III/IV
endometriosis after surgery in Halim Fertility Centre, Dept
O and G, H. Adam Malik Hospital, Medan, Indonesia were
randomized into two groups of 15 patients for 3-month and
14 patients for 6-month course of GnRHa depot for ultralong
down-regulation before undergoing standard protocol of
ovarian stimulation in IVF cycles. Length and dosage of
gonadotrophin use, number of oocyte retrieved, number of
embryo transferred and clinical pregnancy rate were recorded
in both groups and compared.
Results: There were no differences in length and dosage use
of gonadotrophin in both groups, the number of oocyte and
number of embryo transferred. Clinical pregnancy rate in both
groups were comparable (40% versus 35.7%) P < 0.05.
Conclusion: Outcome of IVF in ultralong down-regulation
with GnRHa depot in stage III/IV endometriosis with a 3-
month course and with a 6-month course of GnRHa depot in
IVF were similar.
AC-022
Low-dose urine HMG stimulation improves clinical
outcomes of women with poor-responder indication in
IVF/ICSI treatment when compared with natural cycle
Gong F, Lu GX, Li J, Zhang SP, Lin G
Reproductive and Genetic Hospital Of CITIC-XIANGYA,
China
linggf36@yahoo.com.cn
Introduction: Poor responders were not sensitive to high-dose
gonadotrophin stimulation and usually resulted in low success
rate in IVF treatment. Natural cycle is commonly used but high
cancellation rate were observed due to unsuccessful oocyte
S-25