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MUHAMMAD NAZRUL HAKIM

D.V.M, Ph.D.

CURRICULUM VITAE

Sports Academy
Universiti Putra Malaysia

&
Department of Biomedical Sciences
Faculty of Medicine and Health Sciences
Universiti Putra Malaysia
43400 UPM Serdang, Selangor
Malaysia

Tel: 03-89464298
017-3035555
E-mail: nazrulh@medic.upm.edu.my

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Summary of Curriculum Vitae

Name: MUHAMMAD NAZRUL HAKIM

Address: Sports Academy,Jalan Stadium,Universiti Putra


Malaysia, 43400 UPM Serdang, Selangor

Current Appointment: Associate Professor and Deputy Director.

Field of Specialisation: Pharmacology & Toxicology

Teaching Responsibility: Coordinating 4 courses of Bachelor Science


(Biomedical Sciences) and Doctor of Medicine
program.
Lecturing in 10 other courses in UPM.
Lecturing toxicology for Bachelor Science (Biomedical
Sciences) in KUTPM and UIAM.

Administration: Deputy Director,


Head of Unit (Pharmacology and Toxicology) and
Committee member of 5 Committees in the Faculty of
Medicine and Health Sciences.

Research: Research Leader of 5 Projects and associate researcher


of 5 others.
Reviewer of 4 International Refereed Journals and
4 National Refereed Journals

Supervision of Students: 32 Postgraduate (12 as Main supervisor) and


121 undergraduate students (56 as Main supervisor).

Publications: 80 in Journals (58 in International Refereed Journals, 10


National Refereed Journals, 12 submitted) and
87 in Proceedings (9 in International Proceedings).
1 Patent (Pending)

Membership of Professional Bodies: Member of 6 International and


5 National Scientific societies

Honours: 21 medals (2 Gold, 6 Silver and 13 Bronze)


in Research Exhibitions
Recipient of Excellent Service Award 2002 & 2003
Recipient of Quality Award 2001

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Name : MUHAMMAD NAZRUL HAKIM

Department : Biomedical Sciences

Faculty : Medicine and Health Sciences

Field of Specialization : Pharmacology and Toxicology

Date of Birth : 8 June 1969

I. Education and Academic Qualifications

a. Universiti Pertanian Malaysia 1994 D.V.M.

b. St. Mary’s Hospital


Imperial College School of Medicine,
University of London. 1998 Ph.D.

II. Previous Academic and Other Relevant Appointments

1. May 2003 till now Associate Professor


Faculty of Medicine and Health
Sciences.UPM

2. Jan 2004 till now Research Fellow


Laboratory of Natural Resources
Institute Bioscience, UPM

3. Sept 2003 - Sept 2006 Research Fellow


Lab. of Immunotherapeutics and
Vaccines, Institute of Bioscience,
UPM

4. December 1998 -May 2003 Lecturer


Faculty of Medicine and Health
Sciences

5. Jan 2002 – Jan 2004 Research Fellow


Laboratory Pharmaceutical and
Nutraceutical Institute
Bioscience, UPM

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6. March 2001 – March 2002 Research Fellow
Drug Discovery Unit
Institute Bioscience, UPM

7. December 1995 - November 1998 Tutor


Dept. of Biomedical Sciences,
Faculty of Medicine and Health
Sciences, UPM

8. April 1995 - November 1995 Veterinary Surgeon


Teratai Agriculture Sdn. Bhd.
Melaka.

9. June 1994 - March 1995 Research Assistant


Faculty of Veterinary Medicine
UPM

III. Honours /Academic Awards

• Recipient of the Gold Medal for the 17th International Invention, Innovation,
Industrial Design Technology Exhbition Malaysia (I-TEX 2006)
Project title: A natural compound, isolated and purified from a local
herbal plant, interferes with cervical intra epithelial
carcinoma progression.
Status : Researcher
Place : Kuala Lumpur Convention Centre.
Date : 19 May 2006 - 21 May 2006
Organiser : Ministry of Science, Technology and Innovations

• Recipient of the Silver Medal for the Universiti Putra Malaysia Research
Exhibition 2006.
Project title : A natural compound from a local herbal plant indicates
a cornerstone for establishing a reliable, preventive and
curative agent for cervix cancer.
Status : Researcher
Place : Universiti Putra Malaysia
Date : 22-24 August 2006

• Recipient of the Silver Medal for the Universiti Putra Malaysia Research
Exhibition 2006.
Project title : In vivo studies on cervical cancer induced female
Balb/C mice revealed IL-6 as a potential marker.
Status : Researcher
Place : Universiti Putra Malaysia
Date : 22-24 August 2006

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• Recipient of the Bronze Medal for the Universiti Putra Malaysia Research
Exhibition 2006.
Project title : Reserve: Online sports facilities booking system.
Status : Researcher
Place : Universiti Putra Malaysia
Date : 22-24 August 2006

• Recipient of the Gold Medal for the Universiti Putra Malaysia Research
Exhibition 2005.
Project title : Local herbal extracts as alternatives for antibiotics in
broiler chicken production
Status : Researcher
Place : Faculty of Agriculture, Universiti Putra Malaysia
Date : 12-14 March 2005
Organiser : Research Management Center, UPM

• Recipient of the Silver Medal for the Universiti Putra Malaysia Research
Exhibition 2005.
Project title : Zerumbone (from Zingiber zerumbet) induces G2/M
phase arrest and apoptosis in ovarian cancer cells of
human origin.
Status : Researcher
Place : Faculty of Medicine & Health Sciences, Universiti
Putra Malaysia
Date : 8-10 March 2005
Organiser : Research Management Center, UPM

• Recipient of the Silver Medal for the Universiti Putra Malaysia Research
Exhibition 2005.
Project title : Zerumbone (from Zingiber zerumbet ) intervenes the
progression of cervical cancer in female balb/c mice
Status : Researcher
Place : Institute of Bioscience, Universiti Putra Malaysia
Date : 9-12 March 2005
Organiser : Research Management Center, UPM

• Recipient of the Silver Medal for the Universiti Putra Malaysia Research
Exhibition 2005.
Project title : "Zerumbone (from Zingiber zerumbet ) show evidence
of similar anticancer activity to cisplatin in human
cervical cancer cells"
Status : Researcher
Place : Institute of Bioscience, Universiti Putra Malaysia
Date : 9-12 March 2005
Organiser : Research Management Center, UPM

• Recipient of the Bronze Medal for the Universiti Putra Malaysia Research
Exhibition 2005.
Project title : Comparative analgesic activity of ketoprofen and
Channa spp extracts in mice

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Status : Researcher
Place : Faculty of Veterinary Medicine, Universiti Putra
Malaysia
Date : 9-12 March 2005
Organiser : Research Management Center, UPM

• Recipient of the Bronze Medal for the Universiti Putra Malaysia Research
Exhibition 2005.
Project title : Mechanism of hepatotoxicity induced by antifungal
drugs itraconazole anf fluconazole: Involvement of
cytochrome P450
Status : Project Leader
Place : Faculty of Medicine & Health Sciences, Universiti
Putra Malaysia
Date : 8-10 March 2005
Organiser : Research Management Center, UPM

• Recipient of the Bronze Medal for the Universiti Putra Malaysia Research
Exhibition 2005.
Project title : Male contraceptive potentials of ethanol extract of
Carica papaya seeds
Status : Researcher
Place : Faculty of Medicine & Health Sciences, Universiti
Putra Malaysia
Date : 8-10 March 2005
Organiser : Research Management Center, UPM

• Recipient of the Bronze Medal for the Universiti Putra Malaysia Research
Exhibition 2005.
Project title : Protein for wound healing
Status : Researcher
Place : Institute of Bioscience, Universiti Putra Malaysia
Date : 9-12 March 2005
Organiser : Research Management Center, UPM

• Recipient of the Bronze Medal for the Expo Science, Technology and
Innovation 2004.
Project title : Anti-nociceptive (pain killing) agents from three local
Channa spp. Fish.
Status : Project Leader
Place : Putra World Trade Centre, Kuala Lumpur.
Date : 27-29 August 2004
Organiser : Ministry of Science, Technology and Innovation,
Malaysia.

• Recipient of the Silver Medal for the Institute of Bioscience, Universiti Putra
Malaysia Research Exhibition 2004.
Project title : Human Epidermal Growth Factor: The Cloning process.
Status : Researcher
Place : Universiti Putra Malaysia

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Date : 19-21 August 2004
Organiser : Institute of Bioscience, UPM

• Recipient of the Bronze Medal for the Institute of Bioscience, Universiti Putra
Malaysia Research Exhibition 2004.
Project title : Euphorbia hirta: A potential antibacterial and
antifungal agent.
Status : Project Leader
Place : Universiti Putra Malaysia
Date : 19-21 August 2004
Organiser : Institute of Bioscience, UPM

• Recipient of the Bronze Medal for the Institute of Bioscience, Universiti Putra
Malaysia Research Exhibition 2004.
Project title : Fatty acid composition of three Malaysian Channa spp.
Fish.
Status : Project Leader
Place : Universiti Putra Malaysia
Date : 19-21 August 2004
Organiser : Institute of Bioscience, UPM

• Recipient of the Bronze Medal for the Institute of Bioscience, Universiti Putra
Malaysia Research Exhibition 2004.
Project title : Cloning and Sequencing of Human Epidermal growth
factor (hEGF) gene for clinical application of wound
healing.
Status : Researcher
Place : Universiti Putra Malaysia
Date : 19-21 August 2004
Organiser : Institute of Bioscience, UPM

• Recipient of the Bronze Medal for the Universiti Putra Malaysia Research
Exhibition 2003.
Project title : Antifungal and Antibacterial agents from three local
Cassia spp. Herb
Status : Project Leader
Place : Universiti Putra Malaysia
Date : 8-10 July 2003
Organiser : Research Management Center, UPM

• Recipient of the Bronze Medal for the Universiti Putra Malaysia Research
Exhibition 2003.
Project title : Potential of Three Local Euphorbiacea Plants as
Antimicrobial Agents
Status : Project Leader
Place : Universiti Putra Malaysia
Date : 8-10 July 2003
Organiser : Research Management Center, UPM

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• Recipient of the Bronze Medal for the Universiti Putra Malaysia Research
Exhibition 2003.
Project title : Anti-inflammatory properties of three local Channa
spp. fish.
Status : Project Leader
Place : Universiti Putra Malaysia
Date : 8-10 July 2003
Organiser : Research Management Center, UPM

• Recipient of the Bronze Medal for the Faculty of Medicine and Health
Sciences Research Exhibition 2003.
Project title : Mecahnism of hepatotoxicity of azole anti fungal drugs:
Involvement of Cytochrome P450
Status : Project Leader
Place : Faculty of Medicine and Health Sciences
Date : 12-13 June 2003
Organiser : Faculty of Medicine and Health Sciences

• Recipient of Excellent Service Award 2002 from Universiti Putra Malaysia.

• Recipient of Quality Award for the Quality day 2001, Faculty of Medicine and
Health Sciences, UPM.

• Recipient of 1999 Malaysian Toray Science Foundation Science and


Technology Research grant (MTSF)
Project entitled “The mechanism of toxicity and apoptosis of Nonsteroidal
anti-inflammatory drugs”. (RM 25,000)

• Best oral communication presenter in the British Toxicological Society (BTS)


Annual Congress.
Place : University of Warwick
Date : 24-26 March 1997
Organiser : British Toxicological Society

• Second place in the Poster presentation in the British Pharmacological Society


(BPS) Meeting.
Place : Chester Moat House
Date : 22-24 April 1998
Organiser : British Pharmacological Society,
University of Liverpool,
Zeneca Pharmaceuticals and The Spanish Societies of
Pharmacology and Clinical Pharmacology.

• Best Doctor of Veterinary Medicine Graduate of 1994. (Howel-Jubb Prize)


Faculty of Veterinary Medicine, UPM.

• Listed in the Dean’s List for Academic excellence for 10 semesters


(From 1989 to 1994) in Doctor of Veterinary Medicine Program.

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IV. Teaching Experience

Courses taught from 1998 – 2006

Lectures in Universiti Putra Malaysia

Code Course Title Credit Program No. of Year


Students

BSB 3401 Pharmacology 3+1 BSB 85-110 1998


Lecturer
1999-2004
Coordinator

BMS 3040 Pharmacology 2+1 BSB 70 2005


Coordinator

BSB 3501 Toxicology 2+1 BSB & 120-180 1998-99


BS (KPP) Lecturer
2000-03
Coordinator

BMS 3204 Molecular Toxicology 2+1 BSB 52 2005-06


Coordinator

BMS 5041 Molecular Pharmacology 2 + 1 Postgraduate 12 2005-06


Lecturer

BMS 5040 Drug Metabolism 2+0 Postgraduate 15 2004-05


Coordinator

BMS 5042 Biochemical Toxicology 2 + 1 Postgraduate 10 2005-06


Coordinator

BMS 5044 Monoclonal antibodies 3+0 Postgraduate 10 2005


For diagnosis & treatment Lecturer

BSB 3303 Physiology III 2+1 BSB 85-110 1999-2001


Lecturer

SPP 3302 Alimentary System - MD 80-100 1999-2003


Lecturer

SPP 3400 Basic and Biochemical - MD 80-100 1999-2001


Pharmacology Lecturer
2002-04
Coordinator

ENV4301 Environmental and 2+0 BS(KPP) 25-40 1999-2004


Occupational Lecturer
Toxicology

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Code Course Title Credit Program No. of Year
Students

BSB4000 Project (seminar) 0+6 BSB 80-120 1999-2005


Examiner

SPP 3306 Central Nervous System - MD 80-100 2000-04


Lecturer

BSB 3100 Laboratory Animal 1+1 BSB 85-110 2001-05


Management Coordinator

BSB 3302 Physiology II 3+1 BSB 85 2001


Lecturer

ENV3203 Occupational Health I 3+0 BS(KPP) 25-40 2001-03


Lecturer

ENV4201 Ergonomic 3+0 BS(KPP) 25-40 2001-03


Lecturer

SPP 3304 Urinary System - MD 80-100 2002-04


Lecturer

SPP 3442 Respiratory System - MD 80-100 2002-04


Lecturer

SPP 3532 Cardiovascular System - MD 80-100 2002-04


Lecturer
SPP 3142 Endocrine System - MD 80-100 2004
Lecturer
VPK 3201 Pharmacology & 3+1 DVM 60 2003-06
Toxicology Lecturer

LECTURES IN UNIVERSITY COLLEGE OF TECHNOLOGY AND


MANAGEMENT MALAYSIA (KUTPM)

Code Course Title Credit Program No. of Year


Students

SBD 2073 Pharmacology 2+1 BBM 40 2003-04


& Toxicology Lecturer

LECTURES IN INTERNATIONAL ISLAMIC UNIVERSITY OF MALAYSIA

Code Course Title Credit Program No. of


Year
Students

Toxicology 2+1 BSB 30-60 2004


Coordinator

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BSB – Bachelor of Science (Biomedical Sciences)
BS(KPP) – Bachelor of Science (Environmental and Occupational Health)
BBM – Bachelor of Biomedicine
MD – Doctor of Medicine
DVM – Doctor of Veterinary Medicine

V. Administrative Duties and Other Responsibilities

A. INTERNATIONAL LEVEL

1. Reviewer of Manuscripts
Journal: Toxicology
(Impact Factor of 2.691 Thomson ISI, Journal Citation Reports,
2004)
Publisher: Elsevier
Period: 2005-now

2. Reviewer of Manuscripts
Journal: Archives of Oral Biology
(Ranked 20th in the 'Dentistry, Oral Surgery & Medicine',
with an Impact Factor of 1.158 Thomson ISI, Journal Citation
Reports, 2004)
Publisher: Elsevier
Period: 2005-now

3. Reviewer of Manuscripts
Journal: Archives of Pharmacology
(Impact Factor of 1.963 Thomson ISI, Journal Citation Reports,
2004)
Publisher: Springer Berlin Heidelberg
Period: 2004-now

4. Reviewer of Manuscripts
Journal: Indian Journal of Pharmacology
Publisher: Indian Pharmacological Society
Period: 2004-now

B. NATIONAL LEVEL

1. Vice President, Malaysian Society of Pharmacology and Physiology (MSPP).


(2006-2008)

2. Member of the Organising Committee


Malaysian Science and Technology Congress 2002.
Symposium B: Environment, Biodiversity and Resource Management.
Organised by Confederation of Scientific and Technological Associations in
Malaysia (COSTAM). (17-19 Oct 2002)

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3. Head Judge for the Poster Presentation
18th. Scientific Meeting of Malaysian Society of Pharmacology and
Physiology (MSPP) (28-29 April 2003)

4. Panel for Scholarship in Allied health sector, awarded by Ministry of Science,


Technology and Innovations, Malaysia. (2006)

5. Member of the Patent Evaluation Committee (Pharmaceuticals) for EAR


Projects, Ministry of Science, Technology and Innovation, Malaysia (2005)

6. Panel for National Science Foundation Scholarship, awarded by Ministry of


Science, Technology and Innovations (Pharmaceutical Section) Malaysia.
(2004)

7. Reviewer of Manuscripts
Journal: Malaysian Journal of Health Sciences
Publisher: Universiti Kebangsaan Malaysia
Period: 2005-now

8. Reviewer of Manuscripts
Journal: Pertanika
Publisher: Universiti Putra Malaysia
Period: 2003-now

9. Reviewer of Manuscripts
Journal: Jurnal Veterinar Malaysia (Journal of Veterinary Association of
Malaysia)
Publisher: Faculty of Veterinary Medicine, Universiti Putra Malaysia
Period: 2004-now

10. Reviewer of Manuscripts


Journal: Malaysian Journal of Medicine and Health Sciences
Publisher: Faculty of Medicine & Health Sciences,
Universiti Putra Malaysia
Period: 2005-now

11. Member of the Scientific Committee and Chairman of the scientific sessions
Asian Network of Research on Anti-diabetic Plants (ANRAP) National
Symposium.
Organised by ANRAP, IBS UPM and Malaysian Natural Product Society.
(11-12 Jan 2005)

12. Member of Social and Family Day Subcommittee


9th Scientific Conference of the Electron Microscopy Society of Malaysia
(2000)

13. Member of Scientific Committee of 8th Scientific Conference


Electron Microscopy Society of Malaysia (1999)

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C. UNIVERSITY LEVEL

1. Head, Laboratory of Physical Performance and Skills analysis, Academy of


Sports, Universiti Putra Malaysia. (1 May 2006-now)

2. Acting Director of Academy of Sports, Universiti Putra Malaysia. (Sept. 2006)

3. Advisor, Research and Cultivation of fish, Institute of Bioscience. 2005

4. Head of Evaluation Committee for Health and Allied Sciences Cluster. UPM
Research Management Centre. 2005-06

5. Member of the Subcommittee for Drafting of UPM research policies (2004-


06)

6. Acting Head, Laboratory Pharmaceutical and Nutriceutical, Institute of


Bioscience, UPM (July 2002)

7. Assist. Secretary of the Organising committee, Recent Advances in Animal


Health and Production jointly organised by CENTRAS and Dept. of Animal
Science, UPM (1995)

D. FACULTY LEVEL

1. Head of Publicity Committee, Faculty of Medicine and Health Sciences,


Universiti Putra Malaysia (March 2004 – Sept 2006)

2. Member, Member of Ethics Committee, Faculty of Medicine and Health


Sciences, Universiti Putra Malaysia (16 December 1999 to 16 December
2002)

3. Committee member for ISO 9001 Faculty of Medicine and Health Sciences.

4. Head for the Organising Committee of Seminar in Chromatography, Faculty


of Medicine and Health Sciences (2001)

5. Head for the Organising Committee of Seminar in Gas Chromatography,


Faculty of Medicine and Health Sciences (2001)

6. Head of Layout Section, Faculty of Medicine and Health Sciences Year Book
(2000/01)

7. Examiner of the Final Year Project, Bachelor of Science (Occupational and


Environmental Health) (2000-05)

8. Member of the Public Relation Committee, Faculty of Medicine and Health


Sciences, Universiti Putra Malaysia (2000-Jun 2004)

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9. Committee member “Hari Terbuka Fakulti Perubatan dan Sains Kesihatan
Semperna Sambutan 70 tahun UPM” (2001)

10. Vice Chairman “Persatuan Kebajikan dan Sosial Fakulti Perubatan dan Sains
Kesihatan” (March 2002-July 2003)

11. Member of the Information Technology Committee, Faculty of Medicine and


Health Sciences, Universiti Putra Malaysia (2002-Now)

12. Member of the Care and management of laboratory animals Committee,


Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (2002-
Now)

13. Member of the Laboratory Committee, Faculty of Medicine and Health


Sciences, Universiti Putra Malaysia (June 2004-Now)

14. Member of the Laboratory and Medical equipment Committee, Faculty of


Medicine and Health Sciences, Universiti Putra Malaysia (June 2004-Now)

15. Internal examiner for the viva of the final year, Bachelor of Science
(Occupational and environmental health) (2002-2003)

16. Internal auditor for the “Persatuan Kebajikan dan Sosial Fakulti Perubatan dan
Sains Kesihatan” (July 2003-2005)

17. Committee member of Outward Bound Experience (OBE) Club (2004-2006)

E. DEPARTMENT LEVEL

1. Head of Pharmacology Unit, Department of Biomedical Sciences, (2001-


2006)

2. Head of Toxicology Unit, Department of Biomedical Sciences, (16 July 1999-


1 June 2006)

3. Examiner for final year project (BMS 4999) - 2006

4. Co-ordinator Final Year Project (BMS 4999) (2004/05) and (2005/06)

5. Examiner for the viva of the final year project (BSB 4000) Bachelor of
Science (Biomedical sciences) (2002 -2003)

6. Member of Off Campus Practical (BSB 3999) Committee for Second Year
Biomedical Undergraduate (2000/01)

7. Examiner of the Final Year Project, Bachelor of Science (Biomedical


Sciences) (1998-2004)

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8. Examiner for the scientific writing of the final year project (BSB 4000)
Bachelor of Science (Biomedical sciences) (2003)

9. Member of Organising Committee of Photomicrography Workshop Organised


by Department of Biomedical Sciences, Faculty of Medicine and Health
Sciences (1999).

10. Member of Organising Committee of Micrography Workshop Organised by


Department of Biomedical Sciences, Faculty of Medicine and Health Sciences
(2000).

VI. Research Activities

A. RESEARCH PROJECTS

a. Ongoing research
• Title: Anti-inflammatory and anti-microbial properties of Channa spp.
extracts.
Funding: IRPA project (2002-2005) (RM 232,000.00)
Status: Project Leader
Project Output: 1 PhD, 4 MSc and 3 BSc Students.
3 Publications in refereed Journals and 5 in proceedings.

• Title: The Search for new Anti-fungal agents from local medicinal plants as
an alternative treatment to fungal infections
Funding: IRPA project (2003-2005) (RM 100,000.00)
Status: Project Leader
Project Output: 1 PhD, 2 MSc and 8 BSc students
6 Publications in refereed journals and 13 in proceedings.

• Title: Experimental electrophysiological studies of Vestibular compensation


following unilateral labrythtomised rats.
Funding: IRPA project (2004-2007) (RM 249,000.00)
Status: Researcher
Project Output: 3 MSc and 4 BSc student
4 publications in refereed journals and 6 in Proceedings

• Title: The anti-tumourgenic properties of local plant products from Alpinia


zerumbet and Zingiber zerumbet on cervical and ovarian cancers
respectively in cell cultures and female nude mice.
Funding: IRPA project (2003-2006) (RM 172,000.00)
Status: Researcher
Project Output: 1 PhD and 6 MSc students
2 publications in refereed journals

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• Title: The anti-tumourgenic properties of local plant products flavokawin B,
from Alpinia zerumbet on breast cancer of female nude mice and
breast cancer cell lines.
Funding: IRPA project (2004-2007) (RM 212,000.00)
Status: Researcher
Project Output: 6 MSc students
2 publications in refereed journals

• Title: Development and Production of Therapeutic Epidermal Growth Factor


(EGF) wound healing cream.
Funding: IRPA Strategic Research project (2002-2007) (RM 7,500,000.00)
Status: Researcher
Project Output: 1 PhD and 1 MSc student

• Title: Anti-nociceptive and anti-inflammatory properties of Centella


asiatica.
Funding: IRPA Fundamental Research project (2004-2006) (RM 80,000.00)
Status: Researcher
Project Output: 1 MSc and 8 BSc students
2 Publications in refereed journals and 3 in proceedings.

b. Research Completed

• Title: Investigation and Commercialization of herbal products based on


Centella spp.
Funding: Selangor Government (2002-2004) (RM 100,000.00)
Status: Researcher. Collaboration with Universiti Industri Selangor
Project Output: 1 MSc and 8 BSc students
2 Publications in refereed journals and 3 in proceedings.

• Title: Investigation and Commercialization of herbal products based on


Spirulina. spp.
Funding: Selangor Government (2002-2004) (RM 50,000.00)
Status: Researcher. Collaboration with Universiti Industri Selangor
Project Output: 3 BSc students
1 Publication in refereed journals and 2 in proceedings.

• Title: Mechanism of Toxicity of Nonsteroidal Antiinflammatory drug


Mefenamic Acid
Funding: UPM Short term Funds 2000/01 (RM 10,000.00)
Status: Project Leader
Project Output: 1 MSc and 3 BSc students
1 Publication in refereed journals and 5 in proceedings.

• Title: Mechanism of toxicity of antifungal drugs


Funding: UPM Short term Funds 2000/01 (RM 10,000.00)
Status: Project Leader
Project Output: 1 MSc and 10 BSc students
4 Publications in refereed journals and 3 in proceedings.

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• Title: Mechanism of Diclofenac Hepatitis
Funding: European Union Biomedical Programme (1999-01)
Status: Researcher. Collaboration with several EU countries

• Title: The mechanism of toxicity and apoptosis of Nonsteroidal anti-


inflammatory drugs
Funding: Malaysian Toray Science Foundation (1999-01) (RM 25,000)
Status: Project Leader

• Title: Mechanism of hepatotoxicity of nonsteroidal anti-inflammatory drugs:


the role of protein adducts
Funding: Welcome Trust, United Kingdom (1995/98)
Status: Researcher

• Title: Mechanism of nephrotoxicity of nonsteroidal anti-inflammatory drugs


Funding: Welcome Trust, United Kingdom (1995/98)
Status: Researcher

• Title: Mechanism for halothane hepatitis


Funding: European Union Biomedical Funding contract BMH4-CT96-0658)
Status: Researcher

• Title: Effect of Zinc in toxicity of Brachiaria decumbens in sheep


Funding: IRPA (1994/95).
Status: Research Assistant

VII. Supervision of Students

Supervised 32 Postgraduate students and 121 undergraduate students.

A. Doctor of Philosophy

No. Status Student’s Name Project Title Year


1. Supervisor Zainur Amiruddin Mechanism and site of action (2001/04)
Zakaria of Haruan (Channa striatus)
bioactive components that is
responsible for its
antinociceptive activity
2. Co- Amna Elamin Pathogenesis of Hemorrhagic (2002/05)
Supervisor Mohamed Septicaemia in vivo and in
vitro

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3. Supervisor Siddig Ibrahim Antimicrobial and cytotoxic (2003/06)
Abdel Wahab properties of several local
Zingerberaceae
4. Co- Elysha Nur Ismail Development and Production (2004-07)
Supervisor of Therapeutic Epidermal
Growth Factor (EGF) wound
healing cream from yeast
5. Supervisor Azizan Hadi Saat Exposure of paddy farmers to (2004-07)
several organophosphate
insecticide in Lembah Krian,
Perak
6. Co- Barka Mohamad Safety Assessment of (2005-08)
supervisor Kabeir Bifidobacterium
pseudocatenulatum G4,
potential health benefits and
selection of appropriate food
matrix delivery system
7. Supervisor Samsul Bariah The use of several key (2006-09)
Sharudin proteins for the monitoring
and diagnosis of breast cancer
patients following adjuvant
and neo-adjuvant treatment

B. Masters of Science

No. Status Student’s Name Project Title Year


1. Co- Zainur Amiruddin Characterization of Haruan (1998/00)
Supervisor Zakaria (Channa straitus)
antinoceceptive activity on
NDMA and Opioid receptors
2. Co- Hasiah Abdul Protective effect of (1998/00)
supervisor Hamid Griseofulvin in Signal grass
(Brachiaria decumbens)
toxicity in sheep
3. Co- S.M. Rosli The effect of Cyanide in (1999/01)
Supervisor cassava forage on ruminant
livestock production
4. Co- Mageswary Accumulation and impact of (1999/01)
Supervisor Navappan haze on animal models
5. Supervisor Faizah Sanat NSAID induced toxicity and (2000/02)
Apoptosis
6. Supervisor Nor Shahida Abd Hepatotoxicity of antifungal (2000/02).
Rahman drugs itraconazole and
fluconazole in mice
7. Supervisor Reezal Ishak Antimicrobial activities of (2001/03)
Phallantus spp. and
Euphorbia hirta

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8. Supervisor Elysha Nur Ismail Antimicrobial effects of (2001/03)
extract from Cassia spp.
leaves
9. Supervisor Azmahani Fertility and anti-fertility (2001/03)
Abdullah effects of Herbal preparations
in mice
10. Co- Wai Yee Hoo In vitro Comparative studies (2001/03)
Supervisor of the anti-inflammatory
effect of Channa striatus
(Haruan) and Dioscorea spp.
(Yam) extract.
11. Co- Ruzaidi Azli The effects of Malaysian (2001/03)
Supervisor cocoa procyanidins on
plasma glucose, cholesterol
and insulin levels in diabetic-
induced rats.
12. Supervisor Shamima Abdul Anti-ulcer effects of Solanum (2002/04)
Rahman nigrum, Zingiber
Oassumunar and Piper betle
induced by various
ulcerogens in rats
13. Supervisor Yunus Adam Diuretic Properties of several (2002/04)
local medicinal plants in rats.
14. Supervisor Solihah Mohd Anti-inflammatory properties (2002/04)
Hassan of Channa spp. extracts.
15. Co- Rozaini Mohd Investigation into the use of (2002/04)
Supervisor Zohdi various types of local honey
as an alternative treatment for
burn wounds in animal
model.
16. Supervisor Hanisa Hosni Antiviral properties in
selected medicinal plants; (2002/04)
Centella asiatica Linn.
Against Herpes simplex virus
type 1
17. Co- Faizah Mustaffa Effects of several herbs as
Supervisor wound healing enhancer in (2003/05)
rats
18. Co- Jacklyn Ng Wei Biomaterial affecting the
Supervisor Sze cardiovascular system (2003/05)
19. Co- Suif Sainan Evaluation of antinociceptive
Supervisor and anti-inflammatory (2003/05)
properties of Acanthopanax
trifoliatus in mice and rats
20. Co- Adilius Manual Antinociceptive and anti-
Supervisor inflammatory properties of (2003/05)
Strobilantus crispus in mice
and rats

19
21 Co- Ajantha Sinniah Studies of antitumorigenic
Supervisor effect of flavokawin B on (2003/05)
breast cancer cell lines
22 Co- Zetty Nadia Mohd In vitro studies of a natural
Supervisor Zain plant product, zerumbone, (2003/05)
with chemotherapeutic
potential for ovarian and
cervical cancer
23 Co- Nirmala Devi In vivo studies of Zerumbone
Supervisor Tailan on cervical cancer in female (2003/05)
Balb/c mice
24 Co- Azlina Johari In vitro Anti-inflammatory
Supervisor effects of Channa spp. (2003/05)
Extracts: Thromboxane
pathway
25 Co- Ahmad Faizal Development and Production
Supervisor Abdull Razis of Therapeutic bacterial (2004/06)
Epidermal Growth Factor
(EGF) wound healing cream

C. Supervisor of Bachelor of Science (Biomedical Science) Undergraduates

No. Student’s Name Project Title Year


1. Denniam Wong Toxicity of antifungal drug (1999/00)
Chee Wai Ketoconazole in mice
2. Chong Sook Ngee Toxicity of antifungal drug Fluconazole (1999/00)
in mice
3. Norihan Malek Toxicity of antifungal drug Miconazole (1999/00)
in mice
4. Foo Foong Wong Toxicity of antifungal drug Itraconazole (1999/00)
in mice
5. Salmiza Sabli In vitro toxicity of antifungal drug (1999/00)
Ketoconazole in rat hepatocytes
6. Nor Shahida Abdul In vitro toxicity of antifungal drug (1999/00)
Rahman miconazole in rat hepatocytes
7. Siti Musalamah In vitro toxicity of antifungal drug (1999/00)
Hassan Fluconazole in rat hepatocytes
8. Suraiya Hani In vitro toxicity of antifungal drug (1999/00)
Samsudin Itraconazole in rat hepatocytes
9. Zarani Bt. Mat In vitro antibacterial property and in (2000/01)
Taher vivo effects of Cassia tora (Gelenggang
kecil) extract in mice.
10. Murni Ali In vitro antibacterial property and in (2000/01)
vivo effects of Euphorbia hirta (Ara
Tanah) extract in mice.
11. Elysha Nur Ismail In vitro antibacterial property and in (2000/01)
vivo effects of Cassia alata
(Gelenggang besar) extract in mice.

20
12. Nur Shukriyah Anti-inflammatory, analgesic and anti- (2000/01)
Mohd. Hazir pyretic properties of Zigiber zerumbet
(lempoyang) in mice.
13. Hasliza Hassan In vitro and in vivo cytotoxicity of (2000/01)
nonsteroidal anti-inflammatory drug,
piroxicam in rat hepatocytes.
14. Noor Azlina In vitro and in vivo cytotoxicity of (2000/01)
Mohammad antifungal drug, Turbinafine in rat
hepatocytes.
15. Wan Morni Wan In vitro and in vivo cytotoxicity of (2000/01)
Bakar antifungal drug, Greseofulvin in rat
hepatocytes.
16. Ruddy Hasmawie In vitro studies on the antifungal (2000/01)
properties of Euphorbia hirta (Ara
Tanah) extract.
17. Norli Salleh In vitro studies on the antifungal (2000/01)
properties of Cassia tora (Gelenggang
kecil) extract
18. Reezal Ishak In vitro studies on the antifungal (2000/01)
properties of Cassia alata (Gelenggang
besar) extract.
19. Azmahani Abdullah In vitro studies on the antifungal (2000/01)
properties of Acalypha indica (kucing
galak) extract.
20. Rosylah Abdul In vitro antibacterial property and in (2000/01)
Rashid vivo effects of Acalypha indica (kucing
galak) extract in mice.
21. Halijah Hassan Therapeutic Effect of plant extract (2000/01)
Cantella asiatica on acute ethanol- and
acetic acid – induced gastric mucosal
lesions in rats.
22. Wan Kartini Wan Evaluation of the gastroprotective effect (2000/01)
Manan of Piper betle extract in acute ethanol-
and acetic acid – induced
gastrointestinal ulcer in rats.
23. Noratunlina Rabudin Hepatoprotective effect of Curcuma (2000/01)
longa rhizomes in paracetamol-induced
liver damage in rats
24. Siti Norazlina Analgesic effect of Melastoma (2000/01)
Nordin malabathricum in rats
25. Sarah Fairuzah Antinoceceptive effect of Morinda (2000/01)
Sanusi citrifolia leaves extract in mice
26. Hanisa Hosni The effect of Psidium guajava leaves (2000/01)
extract on controlling pain in mice
27. Nor Hasniza bt. Anti-inflammatory and anti-ulceration (2001/02)
Ibrahim of Solanum nigrum (Terung Meranti)
extract in Mice

21
28. Shamima Abdul Anti-pyretic, anti-inflammatory (2001/02)
Rahman properties and induction of would
healing using Ruta grareolens
(Gerunda) extract in mice
29. Noraishah Muhamad Effects of Gynura procumbens (2001/02)
Mokhtar (Sambung nyawa) extracts on serum
glucose, cholesterol and triglycerides
level in normal and alloxan induced
diabetic mice
30. Rafedah Abbas Anti-diabetic effects of Phaeomeria (2001/02)
imperalis (Kantan) extract in normal
and Alloxan induced diabetic mice.
31. Yunus Adam Anti-pyretic and diuretic effects of the (2001/02)
weed Imperata cylindrica (L) in mice.
32. Fathin Ayunie bte. In vitro antimicrobial activities of (2002/03)
Mohd Razif Cantella sibthorpoides and Cantella
javanica extracts
33. Kamarizaldiana Anti-pyretic and anti-inflammatory (2002/03)
Zahari properties of Cantella sibthorpoides and
Cantella javanica extracts in rats
34. Suriati Mohd. Daud Gastroprotective properties of Cantella (2002/03)
sibthorpoides and Cantella javanica
extracts in acetic acid and ethanol
induced ulcers in rats
35. Nor Akma Ismail In vitro antimicrobial activities of 3 (2002/03)
varieties of Spirulina spp. extracts
36. Nor Azura Anti-pyretic and anti-inflammatory (2002/03)
Mohammad properties of 3 varieties of Spirulina
spp. extracts in rats
37. Siti Rahmah Sadiron Gastroprotective properties of 3 (2002/03)
varieties of Spirulina spp. extracts in
acetic acid and ethanol induced ulcers
rats
38. Ernie Nor Hanna Gastroprotective properties of 3 (2002/03)
Idris varieties of Cantella asiatica extracts in
acetic acid and ethanol induced ulcers
in rats
39. Shahrom Bee Anti-pyretic and anti-inflammatory (2002/03)
Ibrahim properties of 3 varieties of Cantella
asiatica extracts in rats
40. Junaina Saiful In vitro antimicrobial activities of 3 (2002/03)
varieties of Cantella asiatica extracts
41. Wan Yuslan Anti-nociceptive properties of three (2003/04)
local Channa spp. Fishes.
42. Mohd Fazinul Anti-inflammatory properties of three (2003/04)
Mustafa local Channa spp. Fishes.
43. Manraj Singh Anti-hypercholesterol and anti- (2003/04)
oxidative effects of Channa straitus in
cholesterol fed rabbits

22
44. Zaiharina Mohamad Anti-diuretic effects of pineapple and (2003/04)
Zamberi papaya extracts in rats.
45. Hang Chong Yee Cytotoxicity of several synthetic analogs of (2005/06)
ZII in human Cervical and Ovarian Cancer
cell lines
46. Lim Kok Choon Cytotoxicity of several synthetic analogs of (2005/06)
ZII in human Cervical and Ovarian Cancer
cell lines
47. Lim Huey Fern Cytotoxicity of several synthetic analogs of (2005/06)
ZII in human Cervical and Ovarian Cancer
cell lines
48. Jason Lim Jee Sern The study of chemical analogues having (2005/06)
anti-cancer activities on human cervical and
ovarian cancers
49. Yong Khim Foo In vivo activities of chemically synthesised (2005/06)
analogues as anti-cancer for cervix
50. Norisa Ahmed Faizor The screening of chemical analogues (2005/06)
having probable anti-tumourgenic activities
in human breast cancer cells
51. Tan Wee Peng Anti-inflammatory and anti-pyretic (2005/06)
properties of Hibiscus rosa sinensis

D. Co-Supervisors of Bachelor of Science (Biomedical Science) Undergraduates

No. Student’s Name Project Title Year


52. Gan Chin Chin The effects of lead overload on the (1999/00)
morphology of selected tissue of rats
with particular emphasis on the nervous
system.
53. Siti Aishah Bujang Efficiency of a combined treatment of (1999/00)
Dukung anak, Pegaga and Sugar cane in
prevention of hepatic injury
54. Bohari Yaacob Effectiveness of Solanum torvum (1999/00)
aqueous extract in enhancing mucosal
immunity to Campylobacter jejuni
infection.
55. Abdul Rahim Effectiveness of Solanum torvum aqeous (1999/00)
Osman extract in enhancing peripheral
immunity to Campylobacter jejuni
infection.
56. Ahmad Faizal Faecal antibody kinetics following oral (1999/00)
Othman immunisation with formalin killed
Campylobacter jejuni and a plant-
derived immunomodulator.
57. Norfazrina Bahsri Efficiency of a combined treatment of (1999/00)
Dukung anak, Pegaga and tebu hitam in
treatment of hepatic injury
58. Rosmawati Mat The pathology of benzo-a-pyrine induce (1999/00)
Shair lesion in the lung
59. Lim Jee Hian Benzo-a-pyrine induced lung injury in (1999/00)
rats

23
60. Wan Khairul Anuar The concentration and distribution of (1999/00)
Wan Ali lead (Pb) in tissues of rats
61. Yong Hui Mei The effects of antioxidant drug, (2000/01)
Probucol, on caveolin in the wall of
aorta of cholesterol-fed rats
62. Sh. Shazlina Syed The effects of Vitamin C on caveolin in (2000/01)
Ahmad Shukri the wall of aorta of
hypercholesterolemic rats
63. Norfadzilah Rosdi The effects of Vitamin E (2000/01)
supplementation on caveolin in the wall
of aorta of hypercholesterolemic rats
64. Nor Hasyimah The effects of antioxidant drug, (2000/01)
Rahamad Probucol, on caveolin in the wall of
aorta of cholesterol-fed rabbits
65. Sh. Shazila Syed The influence of fish oil on caveolin in (2000/01)
Ahmad Shukri the wall of aorta of cholesterol-fed
rabbits
66. Umi Kalsum Azman The effects of Vitamin C (2000/01)
supplementation on caveolin in the wall
of aorta of hypercholesterolemic rabbits
67. Tay Bee Hong The pathologic and immunosuppressive (2000/01)
effects of benzo[ghi]perylene on the
lung of rats
68. Lee Lyn Foong The effect of Phenanthrene on the lung (2000/01)
of rats
69. Mohanaapriya Sina Serum Uric acid levels in relation to (2000/01)
Raja dietary habbits and lifestyle of young
adults
70. Selvanesan Sengol A study on reduced superoxide (2000/01)
dismutase activity in erythrocytes on
haemodialysis patients: A possible
factor in the etiology of uremic anemia
71. Azni Amir Musa The effect top-op application of (2000/01)
Cantella asiatica (Pegaga) on would
healing in rats
72. Nursuhadah Development of 99mTc-DMSA Kit for (2001/02)
Mohamed Yusof Renal Imaging
73. Nazefah Ab Hamid Effect of the ethyl acetate fraction from (2001/02)
Acanthus Ilicifolius on Expression of
Several oncogenes of the MDA- MB-
231 Human Mammary Cancer cell line
74. Tuan Badli Shah T. In vitro and in vivo Evaluation of anti- (2001/02)
Jusoh hepadnavirus activity of local
Phyllanthus spp against Duck Hepatitis
B Virus
75. Nor Juliana Ahmad Reformulation of stannous-DTPA kits to (2001/02)
produce a more stable and efficacious
product.

24
76. Azhari Abd. Aziz The Potential Efficacy Of Phaeomeria (2001/02)
speciosa (bunga kantan) And Piper betle
(sireh) As And Anti-Ageing Agent
77. Chan Wai Ting A Database Collection of Ethnic (2001/02)
Variation of Birth Weight and
Anthropometry in Maternal Hospital
Kuala Lumpur
78. Tee Get Bee A study of the proportion of postnatal (2001/02)
depression (PND) based on Edinburgh
Postnatal Depression Scale (EPDS)
among postnatal women in Maternity
Hospital Kuala Lumpur (MHKL)
79. Suria Mohd Saad The effect of Morinda citrifolia (2001/02)
(Mengkudu) On red Blood Cell (RBC)
Parameters Of Cholesterol-Fed Rabbits
80. Mahani Mahadi The Effect Of Aqueous Extract Of (2001/02)
Averrhoa bilimbi (Belimbing buluh) On
Rbc Profiles In Cholesterol-fed Rabbit
81. Hayati Zakaria The Effect Of Averrhoa bilimbi (2001/02)
(Belimbing Buluh) On Inflammatory
Markers In Cholesterol-Fed Rabbit.
82. Azlina Mohd Johari The Effects Of Nigella sativa L. (Black (2001/02)
Cumin) On Anti-inflammatory Activity
And Blood Parameter In Sprague-
Dawley Rats
83. Norshahidan Mohd Determination Of The Ability Of The (2001/02)
Zapor Averrhoa bilimbi Aqueous Extract To
Act As A Hypoglycemic Agent In
Normal And Streptozotocin Induced
Diabetic Rats
84. Ahmad Akira Omar Antinosiseptive Effects Of Melastoma (2001/02)
Farouk malabathricum In Experimental Lab
Mice

85. Chong Lin Chiek Anti-Fertility Activity Of Iguanura (2001/02)


geonomaeformis (Pinang Burung)
Leaves Aqueous Extract On Female
Sprague Dawleys
86. Mohd Zaharil Zainol Kesan Gabungan Ekstrakan Berakeus (2001/02)
Orthosiphon Grandiflorus Atau O.
Stamineus Dan Andrographis
Paniculata Nees Terhadap Tikus Yang
Diaruh Diabetik
87. Nur Shazlina Hanim The effect of ethyl acetate fraction from (2001/02)
Mohd Abd. Shuki Acanthus ilicifolius on the expression of
several oncogenes in the human breast
cancer cell line (MCF-7)

25
88. See Hui Shien Anti-inflammatory and analgesic effects 2003-04
of the methanol extract of Leea indica in
rodents
89. Tan Soo Chia Anti-inflammatory and analgesic effects 2003-04
of the methanol extract of Melicope
ptelefolis in rodents
90. Kho Beng Teik Hepatotoxicity effect of a natural 2003-04
compound, ZII, isolated from Zingiber
zerumbet in the female Balb/C strain
mice
91. Haryani Hasim Evaluation of anti-pyretic properties of 2003/04
Acanthopanax trifoliatus in mice
92. Siti Nazmin Evaluation of antinociceptive and anti- 2003/04
Saifuddin inflammatory properties of
Acanthopanax trifoliatus in mice and
rats
93. Hazlien Patahuddin Evaluation of antinociceptive and anti- 2003/04
inflammatory properties of Piper
sarmentosum in mice and rats
94. Nooraini Noh Evaluation of anti-pyretic and anti- 2003/04
inflammatory properties of
Stenochlaena palustrs in mice and rats
95. Siti Nor Azirah Evaluation of Diabetic properties of 2003/04
Aziman Shah kurma
96. Enoch Kumar Hypoglycemic properties of Oxalis 2003/04
Perimal barrelieri and its effect on wound
healing

E. Supervisor of Bachelor of Science (Medical Sciences)/Medical Doctor (MD)


program

No. Student’s Name Project Title Year


97. Gan Eng Hui A Study on Mefenamic Acid Toxicity and (1999/00)
its Effects on in vitro Cancer Cell Lines

98. Navin Sukilan Acute and Chronic toxicity of APAG-1 (2002/03)


(New Anticancer agent)
99. Johann Johari Tissue toxicity of Eurycoma longifolia (2002/03)
(Tongkat Ali)
100. Fariz Nordin Antinociceptive and anti-inflammatory (2003/04)
effects of Zingiber zerumbet
101. Maszaidi Zainol Antinociceptive and anti-inflammatory (2003/04)
effects of Zingiber zerumbet

26
F. Co-Supervisor for Bachelor of Biomedicine Students (College University of
Technology and Management Malaysia/KUTPM)

No. Student’s Name Project Title Year


102. Siti Hajar Hussin Preliminary study on the anti-inflammatory (2003/04)
activity of aqueous extract of Cocos
nucifera
103. Hazura Sidek Evaluation of wound healing properties of (2003/04)
extract of Cocos nucifera.
104. Lola Abd Rahman Preliminary study on the anti-bacterial (2003/04)
activity of aqueous extract of Cocos
nucifera
105. Shezlin Eleda Preliminary study on the antinociceptive (2003/04)
Shaharuddin activity of aqueous extract of Cocos
nucifera
106. Muhammad Hafiz Preliminary study on the anti-fungal (2003/04)
Abdul Rahman activity of aqueous extract of Cocos
nucifera
107. Abdul Hafis Ideris b. Preliminary study on the anti-pyretic (2003/04)
Marmin activity of aqueous extract of Cocos
nucifera
108. Valsala Preliminary study on the antinociceptive (2004/05)
Ramachandran properties of Muntingia calabura (Kerukup
Siam) leaves in mice
109. Safarul Mustapha Preliminary study on the antinociceptive (2004/05)
properties of Corchorus olitorius (Senaung
betina) leaves in mice
110. Pubalan Sagadevan Effects of opioid antagonists, enzymes and (2004/05)
pH on Corchorus olitorius leaves
antinociception in mice
111. Neelendran Effects of various non-opiod antagonists (2004/05)
Machapuvaliah and solvents on Corchorus olitorius leaves
antinociception in mice
112. Kogilla Vani Effects of NO/cGMP Pathway on (2004/05)
Jayaraman Muntingia calabura leaves antinociception
in mice
113. Ganesh Effects of opioid antagonists, enzymes and (2004/05)
Balakrishnan pH on Muntingia calabura leaves
antinociception in mice
114. Hemalatha S. Effects of various non-opiod antagonists (2004/05)
Manikam and solvents on Muntingia calabura leaves
antinociception in mice
115. Kumaran Nair Mani Effects of NO/cGMP pathway on (2004/05)
Corchorus olitorius leaves antinociception
in mice
116. Subashini Srinivasan Preliminary study on wound healing (2004/05)
properties of Corchorus olitorius leaves in
mice

27
117. Punnitharrani Preliminary study on anti-pyretic (2004/05)
Dorasamy properties of Corchorus olitorius leaves in
mice
118. Kirisnaveni Preliminary study on anti-inflammatory (2004/05)
Kuppusamy properties of Corchorus olitorius leaves in
mice
119. Farah Wahida Preliminary study on antibacterial (2004/05)
Othman properties of methanol extract of
Corchorus olitorius leaves in vitro on 30
types of selected bacteria
120. Nazaratulmawarina Preliminary study on antibacterial (2004/05)
Rambeli properties of chloroform extract of
Corchorus olitorius leaves in vitro on 30
types of selected bacteria
121. Thenamutha Preliminary study on antibacterial (2004/05)
Muniandy properties of methanol extract of
Muntingia calabura leaves in vitro on 30
types of selected bacteria

VIII. PUBLICATIONS

A. Publications in Journals (Local and International)

1. M. Nazrul Somchit, C.W. Wong, A. Zuraini, A. Ahmad Bustamam,


A.H. Hasiah, H.M. Khairi, M.R. Sulaiman, D.A. Israf (2006)
Involvement of Phenobarbital and SKF 525A in the hepatotoxicity of
antifungal drugs itraconazole and fluconazole in rats. Drug and
Chemical Toxicology 29: 1-17.

2. Z.A. Zakaria, I. Reezal, A.M. Mat Jais, M. Nazrul Somchit, M.R.


Sulaiman, A. H.I. Marmin, H. Sidek, M.H.A. Rahim, L. Abdul
Rahman. (2006). Anti-inflammatory, anti-pyretic and wound healing
activities of Cocos nucifera (MATANG type) fresh juice and kernel
extract in experimental animals. Journal of Pharmacology and
Toxicology 1(6): 516-526

3. M. Nazrul Somchit, S Siti Rahmah, A Zuraini, A Ahmad Bustamam,


ZA Zakaria, N Somchit and L Shamsuddin. (2006) Gastroprotective
activity of Spirulina platensis in acetic acid- and ethanol- induced
ulcers in rats. Journal of Natural Remedies. (In press)

4. ZA Zakaria, MR Sulaiman, AM Mat Jais, M. Nazrul Somchit, KV


Jayaraman, G Balakhrisnan, CA Fatimah (2006) The antinociceptive
activity of Muntingia calabura aqueous extract and the involvement of

28
l-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its
observed activity in mice. Fundamental & Clinical Pharmacology 20
365–372.

5. S Ahmad, DA. Israf , NH. Lajis, K Shaari, H Mohamed, AA. Wahab,


KT. Ariffin, WY Hoo, AA Nasaruddin, AK. Arifah A., MR. Sulaiman,
M. Nazrul Somchit (2006) Cardamonin, inhibits pro-inflammatory
mediators in activated RAW 264.7 cells and whole blood. European
Journal of Pharmacology. 538, 188-194.

6. ZA Zakaria, HM Khairi, M Nazrul Somchit, MR Sulaiman, AM Mat


Jais, I. Reezal, NN Mat Zaid, SNZ Abdul Wahab, NS Fadzil, M
Abdullah, CA Fatimah. (2006) The in vitro antibacterial activity and
brine shrimp toxicity of Manihot esculenta var. Sri Pontian
(Euphorbiacea) extracts. International Journal of Pharmacology. 2(2),
216-220.

7. ZA Zakaria, AM Mat Jais, EFP Hernie, H. Zaiton, M Nazrul Somchit,


MR Sulaiman, FO Faizal (2006) The in vitro antibacterial activity of
Tinosprora crispa extracts. Journal of Biological Sciences. 6(2): 398-
401.

8. Quak Sheu Huey, Ahmad Bustamam A, Sharmini Kumaran, Somchit


M Nazrul, MH Lajis, Faridah Abas, ZN Md Zain A. Sinniah (2006)
Chemically synthesised compounds as potential therapeutics for breast
and ovarian cancers. Bioscientist. 4(1), 15-23

9. A.Syahida, D.A.Israf, D. Permana, N.H.Lajis, S.Khozirah, A.W.Afiza,


T.A.Khaizurin, M. Nazrul Somchit, M.R.Sulaiman, A.A.Nasaruddin.
(2006) Atrovirinone inhibits pro-inflammatory mediator release from
murine macrophages and human whole blood. Immunology and Cell
Biology. Volume 84, Number 3, 250-258

10. CN Quek, A. Ahmad Bustamam, M. Nazrul Somchit. (2006). The


Global acceptance of Phyto-medicine for treatment and its influence on
Malaysia’s initiative in Herbal Medicine. Malaysian Journal of
Science and Technology. (In press)

11. Z.A. Zakaria, M. Nazrul Somchit, H. Zaiton, A.M. Mat Jais, M.R.
Sulaiman, F.W. Othman, R. Nazaratulmawarina and C.A. Fatimah
(2006). The In Vitro Antibacterial Activity of Corchorus olitorius
Extracts. International Journal of Pharmacology 2(2): 213-215.

12. Z.A. Zakaria, M.R. Sulaiman, A. K. Arifah, A.M. Mat Jais, M. Nazrul
Somchit, K. Kirisnaveni, D. Punnitharanni, M. Safarul, C.A. Fatimah
and R. Johari. (2006). Anti-inflammatory and anti-pyretic activities of
Corchorus olitorius in rats. Journal of Pharmacology and Toxicology
1(2): 139-146

29
13. A. Zuraini, MR Roa Aziah, AK Arifah, MR Sulaiman and M. Nazrul
Somchit (2006). Aqueous extracts of Andographis paniculata improve
lipid profiles of rats fed with high cholesterol diet. International
Journal of Pharmacology, 2(1): 45-49.

14. M.H. Solihah, M. Nazrul Somchit, D.A. Israf, A. Zuraini, A.K.


Arifah, M.S. Zakaria, Z.A. Zakaria, MR Sulaiman, A.M. Mat Jais.
(2006) Analgesic activity of three local Channa spp. Fish extracts.
Oriental Pharmacy and Experimental Medicine (In Press)

15. Z.A. Zakaria, A.K. Arifah, A.M. Mat Jais, M.R. Sulaiman, M. Nazrul
Somchit. (2006) Amino acid and fatty acid compositions of the
aqueous extract of Channa striatus. Journal of Veterinary
Pharmacology and Therapeutics. 29 (Suppl. 1) 209-210.

16. A. Zuraini, M. Nazrul Somchit, M.H. Solihah, Y.M. Goh, A.K.


Arifah, M.S. Zakari, N. Somchit, M.A. Rajion, Z.A. Zakaria, A.M. Mat
Jais. (2006) Fatty Acid and Amino Acid composition of Three Local
Malaysian Channa spp. Fish. Food Chemistry Volume 97, Pages 674-
678

17. Z.A. Zakaria, C.A. Fatimah, A.M. Mat Jais, H. Zaiton, EFP Henie,
M.Nazrul Somchit, M. Thenamutha, D. Khasturi. (2006). The In Vitro
Antibacterial Activity of Muthingia calabura Extracts. International
Journal of Pharmacology 2(4): 439-442.

18. A Zuraini, T Vadiveloo, M Taufik Hidayat, A.K. Arifah, M.R.


Sulaiman, M. Nazrul Somchit . (2006) Effects of Neem (Azadirachta
indica) leaf extracts on lipid and C-reactive protein concentrations in
cholesterol-fed rats. Journal of Natural Remedies. 6(2), 109-114.

19. M. Nazrul Somchit, M.H. Nur Shukriyah, A. Ahmad Bustamam, A.


Zuraini. (2005) Anti-pyretic and analgesic activities of Zingiber
zerumbet extracts. International Journal of Pharmacology, 1(3): 277-
280.

20. M. Nazrul Somchit, A Zuraini, A Ahmad Bustamam, Nhakhorn


Somchit, M. R. Sulaiman and R. Noratunlina. (2005) Evaluation of the
protective activity of Turmeric (Curcuma longa) in paracetamol-
induced hepatotoxicity. International Journal of Pharmacology 1(3):
252-256.

21. ZA Zakaria, MR Sulaiman, M. Nazrul Somchit, AM Mat Jais (2005)


Evaluation on the onset and offset time of aqueous supernatant of
Haruan (Channa striatus) fillet antinociception administered
subcutaneously in mice. Pakistan Journal of Biological Science. 8(3);
466-469.

22. Z.A. Zakaria, M.R. Sulaiman, M. Nazrul Somchit and A.M. Mat Jais
(2005). Effects of Various Antagonists on the Channa striatus Fillet

30
Extract. Canadian Journal of Physiology and Pharmacology. 83 (7):
635-642.

23. Z.A.Zakaria, M. Safarul, R. Valsala, M.R. Sulaiman, C.A. Fatimah, M.


Nazrul Somchit and A.M. Mat Jais. (2005) The influences of
temperature and naloxone on the antinociceptive activity of Corchorus
olitorius L. in mice. Archives in Pharmacology 372, 55-62.

24. MZ Rozaini, ABZ Zuki, MM Noordin, Y Narimah, M. Nazrul


Somchit (2005) Macroscopic evaluation of burn wounds healing
process treated with different types of honey. Pakistan Journal of
Biological Sciences. 8(5): 672-678.

25. Zakaria ZA, Sulaiman MR, M. Nazrul Somchit, Mat Jais AM, Daud
IA (2005).The effects of L-arginine, D-arginine, L-NAME and
methylene blue on Channa striatus–induced peripheral antinociception
in mice. Journal of Pharmacy and Pharmaceutical Science. 8(2): 199-
206.

26. I. Elysha Nur, M. Nazrul Somchit, I. Reezal, A.R Mutalib, A. Zuraini.


(2005) In vitro antimicrobial activity of Cassia auriculata. Oriental
Pharmacy and Experimental Medicine 5(1), 57-61

27. M. Nazrul Somchit, S. Faizah, E. H. Gan, S. I. Abdul Wahab and A.


Zuraini. (2004) Liver Injury induced by the nonsteroidal anti-
inflammatory drug Mefenamic Acid (Ponstan): An animal model.
Singapore Medical Journal. 45(11); 530-532.

28. M. Nazrul Somchit, AR Norshahida, AH Hasiah, A Zuraini, MR


Sulaiman, MM Noordin. (2004) Hepatotoxicity induced by antifungal
drugs Itraconazole and Fluconazole in rats: a comparative in vivo
study. Human and Experimental Toxicology. 23: 519-525.

29. M. Nazrul Somchit, MR Sulaiman, Z Ahmad and H Hosni. (2004)


Non-opioid antinociceptive activity of Psidium guajava Linn. Leaves
extract. Journal of Natural Remedies. 4(2); 174-178.

30. M. Nazrul Somchit, MR Sulaiman, A Zuraini, L Samsuddin, N


Somchit, DA Israf, S Moin. (2004) Anti-nociceptive and anti-
inflammatory effect of Centella asiatica. Indian Journal of
Pharmacology 36(6): 377-380.

31. MZ Rozaini, ABZ Zuki, MM Noordin, Y Norimah, M. Nazrul


Somchit. 2004. The effects of different types of honey on tensile
strangth evaluation of burn wound tissue healing. International Journal
of Applied Research in Veterinary Medicine. 2(4); 290-296

32. Zakaria, Z.A., Sulaiman, M.R., Mat Jais, A.M., M. Nazrul Somchit.
2004. Effects of α-amylase, protease and lipase on Haruan (Channa

31
striatus) mucus extract antinociceptive activity in mice. Pakistan
Journal of Biological Science. 7(12); 2202-2207.

33. ZA Zakaria, M. Nazrul Somchit, MR Sulaiman, AM Mat Jais (2004)


Preliminary investigation on the antinociceptive activity of haruan
(Channa striatus) fillet extract with various solvent systems. Pakistan
Journal of Biological Science. 7(10); 1706-1710.

34. Z.A. Zakaria, M.R. Sulaiman, M. Nazrul Somchit, A.M. Mat Jais and
D. Israf. (2004). Non-opioid Antinociceptive Activity of Fresh Haruan
(Channa striatus) Fillet Extract. KUTPM Journal of Technology and
Management 1: 6 – 11.

35. MR Sulaiman M. Nazrul Somchit, DA Israf, Z Ahmad, S Moin.


(2004) Antinociceptive effect of Melastoma malabathricum in mice.
Fitoterapia, 75: 667-672.

36. GP Aithal, L Ramsay, AK Daly, M. Nazrul Somchit, JBS Leathart, G


Alexander, JG Kenna, J Caldwell, CP Day. (2004) Hepatic adducts,
circulating antibodies and cytokine polymorphisms in patients with
diclofenac hepatotoxicity. Hepatology. 39(5): 1430-1440.

37. DA Israf, NH Lajis, M. Nazrul Somchit, MR Sulaiman. (2004)


Enhancement of ovalbumin-specific IgA responses via oral boosting
with antigen co-administered with an aqueous Solanum torvum extract.
Life Sciences, 75: 397-406.

38. M. Nazrul Somchit, M.H. Solihah, D.A. Israf, Z. Ahmad, A.K. Arifah,
A.M. Mat Jais. (2004) Anti-inflammatory Activity of Channa straitus,
Channa micropeltes and Channa lucius extracts: Chronic
inflammatory modulation. Journal of Oriental Pharmacy and
Experimental Medicine. 4(2), 91-94.

39. M. Nazrul Somchit, A.R. Mutalib, Z. Ahmad, MR Sulaiman, S. Norli.


(2004) In Vitro Antifungal Activity of Cassia tora L. Journal of
Tropical Medicinal Plants. Vol. 5(1); 15-20.

40. Z.A. Zakaria, M.R. Sulaiman, M. Nazrul Somchit, E.C. Justin, A.M.
Mat Jais. and D. Israf (2003) The role of peripheral L-Arginine/Nitric
Oxide/Cyclic GMP pathway in Haruan (Channa striatus)–induced
antinociception. KUTPM Journal of Technology and Management. 2:
15-25

41. M. Nazrul Somchit, AR Shamima, Z Ahmad and Abdul Salam


Abdullah (2003) Anti-ulcer and wound healing activity of Ruta
graveolens. Oriental Pharmacy and Experimental Medicine Vol 3 (3):
147-151.

42. I. Reezal, M. Nazrul Somchit, I. Elysha Nur, R.Hasmawie, P.P.


Chong, A.R Mutalib, Z. Ahmad (2003) In vitro Antimicrobial activity

32
of aqueous and ethanol extracts of Euphorbia hirta. Journal of
Oriental Pharmacy and Experimental Medicine. Vol 3(4): 191-196.

43. M. Nazrul Somchit, MR Sulaiman, A Zuraini, DA Israf, L Shamsudin


and N Somchit. (2003) Spirulina platensis: An excellent nutraceutical
and a potential pharmaceutical product. Bioscientist 1(2), 4-6.

44. M. Nazrul Somchit, AR Shamima, Z Ahmad and Abdul Salam


Abdullah (2003) Anti-ulcer and wound healing activity of Ruta
graveolens. Oriental Pharmacy and Experimental Medicine Vol 3 (3):
147-151.

45. M. Nazrul Somchit and Nur Shukriyah MH (2003) Antiinflammatory


property of Ethanolic and Aqueous extracts of Zingiber zerumbet.
Indian Journal of Pharmacology 35, 101-102

46. M. Nazrul Somchit, I. Reezal, I. Elysha Nur, A.R. Mutalib. (2003) In


vitro antimicrobial activity of ethanol and water extract of Cassia
alata. Journal of Ethnopharmacology 84, 1-4.

47. M. Nazrul Somchit and AR Nor Shahida. (2003) In vitro


hepatotoxicity of miconazole on rat hepatocytes pretreated with
Phenobarbital. Malaysian Applied Biology 32(1): 1-5.

48. M. Nazrul Somchit, Siti Musalmah H and Suraiya Hani S (2002)


Itraconazole- and Fluconazole-induced toxicity in rat hepatocytes: A
comparative In vitro study. Human & Experimental Toxicology 21(1),
43-48.

49. M. Nazrul Somchit, H. Halijah and W.M. Wan Kartini. (2002)


Antiulcer effect of Centella asiatica and Piper betle extracts: A
comparative study. Journal of Tropical Medicinal Plants Vol 3, No 1,
29-34.

50. M. Nazrul Somchit, Mutalib AR, Ruddy Hasmawie M and Murni A


(2001) In vitro antifungal and antibacterial properties of Euphorbia
hirta. Journal of Tropical Medicinal Plants. Vol. 2 No. 2, 179-182.

51. A.R. Nor Shahida, M. Nazrul Somchit, F.Y. Foo and S. N. Chong
(2001) Hepatotoxicity induced by the anti-fungal drug, itraconazole
but not fluconazole in mice. Asia Pacific Journal of Pharmacology.
Vol 15. Suppl 2. S69

52. I. Elysha Nur, M. Nazrul Somchit, I. Reezal and M. Abdul Rahim


(2001) In vitro anti-fungal and anti-bacterial properties of Cassia alata.
Asia Pacific Journal of Pharmacology. Vol 15. Suppl 2. S60

53. A. Azmahani, M. Nazrul Somchit, I. Elysha Nur and M.T. Zarani


(2001) Preliminary study on the fertility effect of Euphorbia hirta,

33
Cassia alata and Cassia tora extracts in female mice. Asia Pacific
Journal of Pharmacology. Vol 15. Suppl 2. S58-59

54. M. Nazrul Somchit and M.H. Nur Shukriyah (2001) Analgesic, anti-
pyretic and anti-inflammatory properties of Zingiber zerumbet. Asia
Pacific Journal of Pharmacology. Vol 15. Suppl 2. S59

55. S. Faizah, M. Nazrul Somchit and E.H. Gan (2001) In vitro effect of
Nonsteroidal anti-inflammatory drugs, Mafenamic acid and Piroxicam
on cancer cell lines. Asia Pacific Journal of Pharmacology. Vol 15.
Suppl 2. S80

56. I. Reezal, M. Nazrul Somchit, M. Abdul Rahim, M. Ruddy Hasmawie


and A. Murni (2001) Anti-microbial activity of Euphorbia hirta extract
in vitro. Asia Pacific Journal of Pharmacology. Vol 15. Suppl 2. S60-
61

57. Z. Ahmad, K.Y. Yeoh and M. Nazrul Somchit (2001) The effect of
vitamin E supplementation on caveolin in the wall of aorta of
hypercholesterolemic rabbits. Asia Pacific Journal of Pharmacology.
Vol 15. Suppl 2. S75-76

58. Caldwell, J., Fakurazi, S., Ramsay, L.A., M. Nazrul Somchit., Goldin,
R.D. Benoxaprofen forms protein adducts in the bile canaliculi of
female CD1 mice (2000) Toxicol. Sci., 54 (1 SUPPL.) p. 46

59. S. Fakurazi, L. A. Ramsay, M. Nazrul Somchit, R. D. Goldin and J.


Caldwell (2000) Comparative protein adduct expression in the liver of
rats given ibufenac or ibuprofen, Toxicology, Volume 148, Issue 1, 28,
Page 46

60. S. Fakurazi, L. A. Ramsay, M. Nazrul Somchit, R. D. Goldin and J.


Caldwell (1999) Benoxaprofen forms adducts in the bile canalicular
plasma membrane of female CD1 mice. Human and Experimental
Toxicology. 18(12), 753

61. Salam Abdullah, M.A. Rajion, M. Nazrul Somchit, A. Zuraini and


H.M. Khairi (1998) The Protective effect of zinc sulphate in signal
grass (Brachiaria decumbens) toxicity in sheep. Malaysian Applied
Biology 27, 63-65.

62. M. Nazrul Somchit, L. Ramsay, J.G. Kenna and J. Caldwell (1998)


Glucuronidation mediates hepatic protein adduct formation from
diclofenac, but not ibuprofen, in rats: A potential mechanism of
hepatotoxicity. British Journal of Clinical Pharmacology. 46(4) 302P.

63. M. Nazrul Somchit, J.J. Mills, J.G. Kenna and J. Caldwell (1998) Bile
acid induced apoptosis and formation of hepatic protein adducts: A
potential mechanism for sulindac-induced hepatotoxicity. Gut. 32, P25.

34
64. A. Salam Abdullah, M.A. Rajion, M. Nazrul Somchit, A. Zuraini and
H. Khairi (1997) Effects of Brachiaria decumbens (signal grass)
toxicity on plasma levels and excretion of zinc in sheep. Journal of
Veterinary Pharmacology and Therapeutics. 20(1), 272

65. M. Nazrul Somchit, L.T. Wade, I.B. Gradner, J.G. Kenna and J.
Caldwell (1997) Immunochemical identification of modified
hepatic protein adducts which could be involved in the hepatotoxicity
of Diclofenac. British Journal of Clinical Pharmacology. 43(2), 208-
209.

66. M. Nazrul Somchit, L.T. Wade, L. Ramsay, J.G. Kenna and J.


Caldwell (1997) Hepatotoxicity and hepatic protein adduct formation
in rats dosed ip with diclofenac. Human and Experimental
Toxicology. 16(7), 401.

67. M. Nazrul Somchit, L.T. Wade, R.D. Goldin, J.G. Kenna and J.
Caldwell (1997) Sulindac-associated hepatotoxicity: An animal
model. British Journal of Clinical Pharmacology. 45(5), 506P.

68. J.Caldwell, I.B. Gardner, M. Nazrul Somchit, L. Wade and J.G. Kenna
(1997) Role of individual conjugation enzymes for species differences
in toxicity. In “the use of Human in vitro systems to support preclinical
and clinical safety assessment”. (Editors: G.Alvan, A. Lindgren, P.
Moldeus, T. Salmonsson and P. Sjoberg). Tryckgruppen, Stockholm.

B. Papers submitted for publications

69. M. Nazrul Somchit, R. Abdul Rashid, A. Abdullah, A. Zuraini, D.A.


Israf, M.R. Sulaiman, A.R. Mutalib. Antimicrobial activity of
Acalypha indica Linn. Submitted to Fitoterapia (Dec 2005)

70. M. Nazrul Somchit, A. Zuraini, A. Ahmad Bustamam, D.A. Israf,


M.R. Sulaiman, A.R. Mutalib. Antimicrobial activity of Ardisia crispa
(Thunb.) A. DC. Submitted to Journal of Ethnopharmacology (Dec
2005)

71. M. Nazrul Somchit, C.W. Wong, A. Zuraini, A. Ahmad Bustamam, A.


Salam Abdullah. Influence of Cytochrome P450 inhibitors in the in
vitro cytotoxicity of antifungal drugs itraconazole and fluconazole.
Submitted to Human and Experimental Toxicology (October 2006)

72. Z.A. Zakaria, A.M. Mat Jais, M.R. Sulaiman, M. Nazrul Somchit and
S. Subashini (2006). The Antibacterial and Wound Healing Activities
of Aqueous Extracts of Corchorus olitorius. Inflammation Research
(Submitted)

35
73. M. Nazrul Somchit, M Nor Azura, A Zuraini, A Ahmad Bustamam, N
Somchit and L Shamsuddin. Anti-inflammatory and anti-pyretic
properties of Spirulina platensis extract in rats. Submitted to
International Journal of Pharmacology (Feb 2006)

74. AM Mat Jais, ZA Zakaria, T Mori, L McCahon, K Croft, MH Khairi,


AH Hasiah, A Zuraini and M. Nazrul Somchit. Possible Bioactive
Compounds from Channa striatus (Haruan) fish that is responsible for
its antinociceptive activity. Submitted to Journal of Natural Remedies.
(Feb 2006)

75. Ahmad Bustamam A, A Sinniah, M. Nazrul Somchit, MZ Zetty


Nadia, M Habsah, NH Lajis. Flavokawin B isolated from Alpinia
rafflesiana induces apoptosis in both MCF-7 and MDA-MB-231
human breast cancer cell lines but not in MCF-10A normal human
breast epithelial cells. Submitted to Cancer Journal (Oct 2005)

76. Zetty Nadia MZ, Ahmad Bustamam A, M. Nazrul Somchit, Nordin


HL, Ajantha S. Zerumbone isolated from Zingiber zerumbet inhibits
cancer cell growth of human ovarian and cervical origin. Submitted to
Pharmacological Research (Sept 2005)

77. B.A.Ahmad, N.M.Z. Zetty, M. Nazrul Somchit, M.M.Hanif,


T.Nirmala and N.H.Lajis. Selectivity of Zerumbone, a ginger
sesquiterpene compound of Zingiber zerumbet towards CaoV3, HeLa
and HL-60 human cancer cell lines. Submitted to Fitoterapia (Sept
2005)

78. Zetty Nadia MZ, Ahmad Bustamam A, M. Nazrul Somchit, Nordin


HL, Ajantha S. Zerumbone causes reduction in IL-6 secretions and
membrane-bound IL-6R in both human ovarian and cervical cancer
cells. Submitted toCancer Letters (Oct 2005)

79. N Somchit, M. Nazrul Somchit, S Azizan Hadi, A. Ahmad Bustamam,


MP Zakaria. Persistent organic chemicals in Malaysian Waters: A
Review. Submitted to Strategi (March 2005).

80. ZA Zakaria, MR Sulaiman, DA Israf, M. Nazrul Somchit and AM


Mat Jais. Effect of various antagonists on the aqueous portion of fresh
haruan (Channa striatus) fillet antinociceptive activity in mice.
Submitted to Life Sciences (August 2004).

C. Publications in Proceedings (Local and International)

81. A Zuraini, M. Nazrul Somchit, SS Yeap, MS Cheema, AK Arifah and


AM Mat Jais (2006) Lipid-lowering and anti-inflammatory activities
of Channa micropeltes (Toman) in cholesterol-fed rabbits.
Proceedings of the 21st. Scientific Meeting of The Malaysian Society
of Pharmacology and Physiology. PP 6.

36
82. M. Nazrul Somchit, CW Wong, A Zuraini, AA Bustamam, A. Salam
Abdullah. (2006) In vitro cytotoxicity of anti-fungal drugs
itraconazole and fluconazole: Influence of Cytochrome P450
inhibitors. Proceedings of the 21st. Scientific Meeting of The
Malaysian Society of Pharmacology and Physiology. PP 10.

83. M Adilius, MR Sulaiman, M. Nazrul Somchit, M. Ismail, MT Hidayat


(2006) Evaluation of antinociceptive activities of Strobilanthes crispus
ethanolic extract in mice. Proceedings of the 21st. Scientific Meeting
of The Malaysian Society of Pharmacology and Physiology. PP 37.

84. P Enoch Kumar, MR Sulaiman, M. Nazrul Somchit, MT Hidayat, AB


Md Zuki (2006) Hypoglycemic and anti-diabetic effect of aqueous and
ethanol extract of Oxalis barrelieri in streptozotocin-induced diabetic
rat models. Proceedings of the 21st. Scientific Meeting of The
Malaysian Society of Pharmacology and Physiology. PP 42.

85. ZA Zakaria, MR Sulaiman, AK Arifah, M. Nazrul Somchit, AM Mat


Jais, R Johari, M Safarul, R Vasala, K Kirisnaveni, D Punnitharanni
(2005) Antinociceptive, anti-inflammatory and anti-pyretic properties
of Corchorus olitorius aqueous extract in Mice. Proceedings of the
20th. Scientific Meeting of The Malaysian Society of Pharmacology
and Physiology. PP 18.

86. ZA Zakaria, M. Nazrul Somchit, AM Mat Jais, MR Sulaiman, AK


Arifah, R Johari, S Pubalan, M Neelendran, M Safarul, R Vasala
(2005) Effects of various receptor antagonists, enzyme, temperature
and pH on the Antinociceptive activity of Corchorus olitorius in mice.
Proceedings of the 20th. Scientific Meeting of The Malaysian Society
of Pharmacology and Physiology. PP 19.

87. M. Adilius, H Normaizira, MR Sulaiman, M. Nazrul Somchit, M


Ismail, MT Hidayat, ZA Zakaria. (2005) Evaluation of antinociceptive
activities of Alpinia conchigera ethanolic extract in mice. Proceedings
of the 20th. Scientific Meeting of The Malaysian Society of
Pharmacology and Physiology. PP 25.

88. S Sainan, MR Sulaiman, M. Nazrul Somchit, MT Hidayat, ZA


Zakaria. (2005) Evaluation of antinociceptive activities of
Acanthopanax trifoliatus in mice. Proceedings of the 20th. Scientific
Meeting of The Malaysian Society of Pharmacology and Physiology.
PP 26.

89. Z.A. Zakaria, M. Nazrul Somchit, H. Zaiton, A.M. Mat Jais, M.R.
Sulaiman, W.O. Farah, R. Nazaratulmawarina and C.A. Fatimah
(2005). The In Vitro Antibacterial Activity of Corchorus olitorius
Extracts. Proceedings of the 8th Symposium of Malaysian Society of
Applied Biology, 25th – 26th June 2005, Putrajaya, Kuala Lumpur,
Malaysia.

37
90. Z.A. Zakaria, M. Nazrul Somchit, H. Zaiton, A.M. Mat Jais, M.R.
Sulaiman, M. Thenamutha, D. Kasthuri and C.A. Fatimah (2005). The
In Vitro Antibacterial Activity of Muntingia calabura Extracts.
Proceedings of the 8th Symposium of Malaysian Society of Applied
Biology, 25th – 26th June 2005, Putrajaya, Kuala Lumpur, Malaysia

91. AW Siddig Ibrahim, AW Hasan, YM Mohamed Osama, M. Nazrul


Somchit (2005). Evaluating of the traditional use of Clerodendron
capitataum as erection stimulating agent among diabetic patients in
Sudan. Proceedings of Asian Network for the Research of Anti-
diabetic Plants (ANRAP) National Symposium. P5, 26.

92. MZ Rozaini, ABZ Zuki, MM Noordin, Y Norimah, M. Nazrul


Somchit. 2004. Tensile strength evaluation on burns wound healing
treated with nenas (Ananas comosus spp.) and Gelam (Melaleuca spp.)
honey. Proceedings of the 11th. International conference of the
Association of Institution for Tropical Veterinary Medicine and 16th
Veterinary Association Malaysia Congress. 338-339.

93. MZ Rozaini, ABZ Zuki, MM Noordin, Y Norimah, M. Nazrul


Somchit. 2004. Histological evaluation on burns wound healing
treated with nenas (Ananas comosus spp.) and Gelam (Melaleuca spp.)
honey. Proceedings of the 11th. International conference of the
Association of Institution for Tropical Veterinary Medicine and 16th
Veterinary Association Malaysia Congress. 381-383.

94. AR Shamima, M. Nazrul Somchit, MR Sulaiman, AA Nasaruddin


(2004) Anti ulcer effect of Piper betel, Solanum nigrum and Zingiber
cassumunar on ulceration induced by various ulcerogens in rats.
Proceedings of the 19th. Scientific Meeting of The Malaysian Society
of Pharmacology and Physiology. 116.

95. M. Nazrul Somchit, S. I. Abdelwahab (2004) Antimicrobial screening


for some Malaysian Flora. Proceedings of the 19th. Scientific Meeting
of The Malaysian Society of Pharmacology and Physiology. 107

96. S. I. Abdelwahab, O.Y. Mohamed., H.M. Abdelwah and M. Nazrul


Somchit (2004) Some pharmacological properties of the Sudanese
Medicinal plant Clerodendron capitatum. Proceedings of the 19th.
Scientific Meeting of The Malaysian Society of Pharmacology and
Physiology. 106

97. MH Solihah, M. Nazrul Somchit, DA Israf, Z Ahmad, AK Arifah,


AM Mat Jais and MS Zakaria (2004) Antinociceptive effects of
Channa Striatus (Haruan), Channa micropeltes (Toman) and Channa
lucius (Bujuk) extracts. Proceedings of the 19th. Scientific Meeting of
The Malaysian Society of Pharmacology and Physiology. 93.

38
98. Y Adam, M. Nazrul Somchit, MR Sulaiman, AA Nasaruddin and A
Zuraini. (2004) Diuretic properties of several local medicinal plants in
rats. Proceedings of the 19th. Scientific Meeting of The Malaysian
Society of Pharmacology and Physiology. 101.

99. PE Kumar, M Taufik, Z Ahmad, M. Nazrul Somchit, MR Sulaiman


and H Ithnin (2004) The hypoglycaemic properties of Oxalis berrelieri
and its effect on wound healing. Proceedings of the 19th. Scientific
Meeting of The Malaysian Society of Pharmacology and Physiology.
50.

100. Z.A. Zakaria, M. Safarul, R. Valsala, M.R. Sulaiman, C.A. Fatimah


and M. Nazrul Somchit (2004). Influence of Temperature on the
Opioid-mediated Antinociceptive Activity of Corchorus olitorius L. in
mice. Proceedings of the 20th Annual Seminar of the Malaysian
Natural Products Society, 29th – 30th November 2004, Kuching,
Sarawak, Malaysia.

101. Z.A. Zakaria, R. Valsala, M.R. Sulaiman, M. Nazrul Somchit and


C.A. Fatimah (2004). The Heat-stable Antinociceptive Activity of
Aqueous Extract of Muntingia calabura Leaves is Mediated via Opioid
Receptor. Poster presented at the 20th Annual Seminar of the Malaysian
Natural Products Society, 29th – 30th November 2004, Kuching,
Sarawak, Malaysia

102. AW Siddig Ibrahim, M. Nazrul Somchit, AW Hasan, YM Mohamed


Osama (2004). Isolated tissues as a model to investigate serotonergic
properties of Clerodendron capitatum. Proceedings of 2nd. Singapore
International Neuroscience Conference. A-7.

103. H. Sidek, S.T. Husin, Z.A. Zakaria, R. Ishak, A. Harun, A. M. Salim,


N.A. Rashid, R. Jajuli, J.A. Hamid, M. Nazrul Somchit, M.R.
Sulaiman and A.M. Mat Jais (2004). Wound Healing and Anti-
inflammatory Activity of Local Coconuts, Cocos nucifera. Poster
presented at the 4th Malaysian Pharmaceutical Society (MPS)-UiTM
Pharmacy Scientific Conference 2004, 6th – 8th August 2004, Kuala
Lumpur, Malaysia.

104. M.H.A. Rahim, L. Sabtu, Z.A. Zakaria, R. Ishak, A. Harun, A. M.


Salim, H. Harun, N.A. Yusof, J.A. Hamid, M. Nazrul Somchit, M.R.
Sulaiman, M.I. Adenan and A.M. Mat Jais (2004). Antibacterial and
Antifungal Actvities of Local Coconuts, Cocos nucifera. Poster
presented at the 4th Malaysian Pharmaceutical Society (MPS)-UiTM
Pharmacy Scientific Conference 2004, 6th – 8th August 2004, Kuala
Lumpur, Malaysia

105. MR Sulaiman, H. Patahuddin, M. Nazrul Somchit, DA Israf, Z


Ahmad, S Moin and M Taufik Hidayat (2004) Antinociceptive and
anti-inflammatory activity of Piper sarmentosum aqueous extract.

39
Proceedings of Medicinal and Aromatic Plants: Current Trends and
Perspectives. Forest Research Institute Malaysia. 84

106. A Sinniah, A Ahmad Bustamam, M. Nazrul Somchit, NH Lajis, MZ


Zetty Nadia (2004) Flavokawin B (From Zingiberaceae family) has
similar mode of action to tamoxifen in MCF-7 human breast cancer
cells. Proceedings of 4th Frontier Resources in Microbiology Forum.
Forest Research Institute Malaysia.18; P13

107. MZ Zetty Nadia, A Ahmad Bustamam, M. Nazrul Somchit, NH Lajis,


A Sinniah (2004) A natural compound from Zingiber zerumbet
regresses IL-6 secretions in both ovarian and cervical cancer cell of
human origin. Proceedings of 4th Frontier Resources in Microbiology
Forum. Forest Research Institute Malaysia.18; P14

108. AM Haniff, A Ahmad Bustamam, M. Nazrul Somchit, BT Kho, N


Tailan, NH Lajis, MZ Zetty Nadia, A Sinniah (2004) Zerumbone (from
Zingiber zerumbet) intervenes the progression of cervical cancer in
female balb/c mice. Proceedings of the International Biomedical
Science Conference, Kunming, China. P44, Page 96.

109. ZA Zakaria, R Visala, MR Sulaiman, C Fatimah, M. Nazrul Somchit,


AM Mat Jais. (2004) Preliminary study on the antinociceptive
properties of aqueous extract of Muntingia calabura leaves in mice.
Proceedings of 20th Annual Seminar of the Malaysian Natural Product
Society. P45, 80.

110. MR Sulaiman, M. Nazrul Somchit, DA Israf, S Moin, Z Amom, M


Taufik-Hidayat. (2004) Antinociceptive effect of the aqueous extract
of Zingiber zerumbet. Proceedings of 20th Annual Seminar of the
Malaysian Natural Product Society. P46, 80-81.

111. A Azmahani, M. Nazrul Somchit, S Sukardi, A Salam Abdullah and


WM Wan Nordin.(2003) The Effects of Andographis paniculata,
Carica papaya AND Cassia alata Extracts on the reproductive system
of male mice. Proceedings of the 18th. Scientific Meeting of The
Malaysian Society of Pharmacology and Physiology. 31

112. I. Elysha Nur, M. Nazrul Somchit, Z. Ahmad, A.R Mutalib (2003)


Antibacterial and wound healing properties of Cassia fistula and
Cassia auriculata. Proceedings of the 18th. Scientific Meeting of The
Malaysian Society of Pharmacology and Physiology. 32

113. S Faizah, M. Nazrul Somchit, DA Israf, J Stanlas and O Fauziah


(2003) In vitro cytotoxicity of nonsteroidal anti-inflammatory drugs
(NSAIDs) Piroxicam and Mefenamic Acid in Phenobarbital-pretreated
rat hepatocytes. Proceedings of the 18th. Scientific Meeting of The
Malaysian Society of Pharmacology and Physiology. 27-28

40
114. I. Reezal, M. Nazrul Somchit, AR Mutalib, Z. Ahmad. (2003)
Evaluation of the Antimicrobial activity of aqueous and ethanol
extracts from Euphorbia hirta and Phyllanthus niruri. Proceedings of
the 18th. Scientific Meeting of The Malaysian Society of Pharmacology
and Physiology. 26

115. AR Shamima M. Nazrul Somchit, Z. Ahmad,SI Abdul Wahab (2003)


Ruta graveolens (Geruda) properties in ethanol induced ulcer in mice.
Proceedings of the 18th. Scientific Meeting of The Malaysian Society
of Pharmacology and Physiology. 51-52

116. M.H. Solihah, M. Nazrul Somchit, D.A. Israf, Z. Ahmad, A.K. Arifah,
M.S. Zakaria, A.M. Mat Jais. (2003) Anti-inflammatory activities of
Channa striatus (HARUAN) AND Channa lucius (BUJUK) extracts.
Proceedings of the 18th. Scientific Meeting of The Malaysian Society
of Pharmacology and Physiology. 52-53

117. M. Nazrul Somchit, Ahmad Z, Zahari KL, Shamsudin L, Somchit N.


and Sulaiman MR. (2003) Anti-pyretic and anti-inflammatory
properties of Centella asiatica. Proceedings of the 18th. Scientific
Meeting of The Malaysian Society of Pharmacology and Physiology.
54-55

118. Y.Adam, M. Nazrul Somchit, Z. Ahmad, S.I. Abdul Wahab, M.R.


Sulaiman. (2003) Antidiuretic effect of the weed Imperata cylindrica
(LALANG). Proceedings of the 18th. Scientific Meeting of The
Malaysian Society of Pharmacology and Physiology. 53

119. Zuraini A, Siti Sakinah AH, Arifah AK, Sulaiman MR, M. Nazrul
Somchit, Somchit N and Shamsudin L. (2003) Lipid-lowering
properties of two varieties of Spirulina platensis (Indian and local) in
rats fed with high cholesterol diet. Proceedings of the 18th. Scientific
Meeting of The Malaysian Society of Pharmacology and Physiology.
54

120. Sulaiman MR, M. Nazrul Somchit, Manual A, Zakaria ZA, Ahmad Z


Shamsudin L, Mat Jais AM, Israf DA (2003) The antinociceptive
effects of Centella asiatica in mice. Proceedings of the 18th. Scientific
Meeting of The Malaysian Society of Pharmacology and Physiology.
55

121. AK Arifah, YH Wai DA Israf, M. Nazrul Somchit, AM Mat Jais, A


Zuraini (2003) Comparison of the selective inhibitory effects of
ketoprofen and local medicinal plants on the cyclooxygenase-1 and -2
activity expressed in a goat whole blood system. Proceedings of the
18th. Scientific Meeting of The Malaysian Society of Pharmacology
and Physiology. 50

122. Zakaria ZA, Sulaiman, MR, M. Nazrul Somchit, Ahmad Z, Justin EC


Israf DA and Mat Jais AM (2003) Determination on the involvement

41
of peripheral L-arginine/nitric oxide/cyclic guanosine 3’: 5’-
monophosphate pathway in aqueous portion of fresh haruan (Channa
striatus) fillet antinociceptive activity. Proceedings of the 18th.
Scientific Meeting of The Malaysian Society of Pharmacology and
Physiology. 24-25.

123. A Azmahani, M. Nazrul Somchit, S Sukardi, A Salam Abdullah and


WM Wan Nordin.(2003) The Effects of Andographis paniculata,
Carica papaya AND Cassia alata Extracts on the reproductive system
of mice. Proceedings of the 7th Symposium of Applied Biology. 108-
112

124. I. Elysha Nur, M. Nazrul Somchit, Z. Ahmad, A.R Mutalib. (2003) In


vitro Antimicrobial Activity of Cassia fistula. Proceedings of the 7th
Symposium of Applied Biology. 113-116

125. S Faizah, M. Nazrul Somchit, DA Israf, J Stanlas and O Fauziah.


(2003) In vitro cytotoxicity of nonsteroidal anti-inflammatory drugs
(NSAIDs) Piroxicam and Mefenamic Acid in normal rat hepatocytes.
Proceedings of the 7th Symposium of Applied Biology. 126

126. I. Reezal, M. Nazrul Somchit, Z. Ahmad, AR Mutalib, M Ruddy


Hasmawie, A Murni. (2003). Evaluation of the antibacterial and
antifungal activities of Acalypha indica. Proceedings of the 7th
Symposium of Applied Biology. 117-120

127. AR Norshahida, M. Nazrul Somchit, O Fauziah and A Salam


Abdullah. (2003) In vitro cytotoxicity of antifungal drugs itraconazole
in rat hepatocytes: Involvement of Cytochrome P450. Proceedings of
the 7th Symposium of Applied Biology. 125

128. AR Shamima, M. Nazrul Somchit, Z. Ahmad, SI Abdul Wahab


(2003) Wound healing activities of Ruta graveolens ( Geruda ) in mice.
Proceedings of the 7th Symposium of Applied Biology. 127-129

129. M.H. Solihah, M. Nazrul Somchit, D.A. Israf, Z. Ahmad, A.K. Arifah,
M.S. Zakaria, A.M. Mat Jais. (2003) Anti-inflammatory activities of
Channa striatus (Haruan) and Channa lucius (Bujuk) extracts.
Proceedings of the 7th Symposium of Applied Biology. 70-73

130. M. Nazrul Somchit, Z. Ahmad, NA Mohammad, L Shamsudin, N.


Somchit and MR Sulaiman. (2003) Anti-pyretic and Anti-
inflammatory Properties of Spirulina platensis. Proceedings of the 7th
Symposium of Applied Biology. 104-106.

131. Y.Adam, M. Nazrul Somchit, Z. Ahmad, S.I. Abdul Wahab, M.R.


Sulaiman. (2003). Antipyretic effect of the weed Imperata cylindrica
(LALANG) Proceedings of the 7th Symposium of Applied Biology.
121-124

42
132. Zuraini A, Ros Aziah MR, Arifah AK, Sulaiman MR and M. Nazrul
Somchit. (2003). Aqueous extracts of Andographis paniculata
(Hempedu Bumi) improve lipid profiles of rats fed with high
cholesterol diet. Proceedings of the 7th Symposium of Applied
Biology. 107

133. Sulaiman MR, M. Nazrul Somchit, Sainan S, Ahmad Z, Israf DA and


Moin S (2003) Analgesic activity of Andrographis paniculata in mice.
Proceedings of the 7th Symposium of Applied Biology. 137-140

134. Zakaria ZA, Sulaiman, MR, M. Nazrul Somchit, Ahmad Z, and Mat
Jais AM (2003) Non-opioid antinociceptive activity of fresh haruan
(Channa striatus) fillet extract. Proceedings of the 7th Symposium of
Applied Biology. 141

135. AK Arifah, YH Wai DA Israf, M. Nazrul Somchit, AM Mat Jais, A


Zuraini (2003) Optimization of Whole blood assay for synthesis of
cyclooxygenase-1 and -2 using A23187 and lipopolysaccharide
stimulation of thromboxane B2 production. Proceedings of the 7th
Symposium of Applied Biology. 45-48.

136. I. Reezal, I. Elysha Nur, M. Nazrul Somchit, WM Wan Nordin, AM


Mat Jais, A. Salam Abdullah. (2003). Effects of Acalypha indica on
healing activity of surgical wounds in mice. Proceedings of Seminar of
Update on Microscopy and Microanalysis. 26-27

137. Elysha Nur, I. Reezal, I. M. Nazrul Somchit, WM Wan Nordin, AM


Mat Jais, A. Salam Abdullah. (2003). Wound healing activity of
Cassia fistula: Histopathological study. Proceedings of Seminar of
Update on Microscopy and Microanalysis. 28-30.

138. Z Ahmad, M. Nazrul Somchit, AB Mutalib and S Norli (2002) In vitro


antifungal properties of Cassia Tora (Gelenggang Kecil) extracts.
Proceedings of the Regional Symposium on Environment and Natural
Resources. Vol. 1, 472-476.

139. A. Azmahani, M. Nazrul Somchit and A. R. Rosyilah (2002) In vitro


anti-bacterial and Anti-fungal properties of Acalypha indica (Kucing
Galak). Proceedings of the Regional Symposium on Environment and
Natural Resources. Vol. 1, 503-508.

140. I. Elysha Nur, M. Nazrul Somchit and M. Abdul Rahim. (2002) In


vitro antibacterial activity and effects of Cassia alata in livers of mice.
Proceedings of the Regional Symposium on Environment and Natural
Resources. Vol. 1, 509-515.

141. I Reezal, M. Nazrul Somchit, M Abdul Rahim. (2002) In vitro


antifungal properties of Cassia alata (Gelenggang besar). Proceedings
of the Regional Symposium on Environment and Natural Resources.
Vol. 1, 654-659.

43
142. M. Nazrul Somchit, MR Sulaiman, R Noratunlina and Z Ahmad
(2002). Hepatoprotective effects of Curcuma longa rhizomes in
paracetamol-induced liver damage in rats. Proceedings of the Regional
Symposium on Environment and Natural Resources. Vol. 1, 698-702.

143. M. Nazrul Somchit, A.R. Nor Shahida, M.H. Nur Shukriyah. (2002)
Anti-pyrexia and analgesic activities of Zingiber zerumbet
(Lempoyang). Proceedings of the Regional Symposium on
Environment and Natural Resources. Vol. 1, 692-697.

144. S Faizah, M. Nazrul Somchit and MH Shukriyah (2002) Zingiber


zerumbet (Lempoyang): A potential anti-inflammatory agent.
Proceedings of the Regional Symposium on Environment and Natural
Resources. Vol. 1, 516-520.

145. A. Azmahani, M. Nazrul Somchit, H. Halijah and W.M. Wan Kartini


(2002) Antiulcer effect of Centella asiatica and Piper betle extracts: A
comparative study. Proceedings of the 4th. Asian Science and
Technology Congress. B-23P

146. I.Elysha Nur, M. Nazrul Somchit, M. Abdul Rahim and M.T. Zaraini
(2002) Antibacterial activities of Cassia Alata and Cassia Tora.
Proceedings of the 4th. Asian Science and Technology Congress. B-
24P

147. Reezal Ishak, M. Nazrul Somchit, M Abdul Rahim, M Ruddy


Hasmawie, AR Rosyilah (2002) In vitro antifungal properties of
Euphorbia hirta and Acalypha indica. Proceedings of the 4th. Asian
Science and Technology Congress. B-25P

148. M. Nazrul Somchit, MR Sulaiman, H Hosni and Z Ahmad (2002)


Antinociceptive effect of Psidium guajava Linn. Leaves extract in
mice. Proceedings of the 4th. Asian Science and Technology Congress.
B-26P

149. MR Sulaiman, AA Omar Farouk and M. Nazrul Somchit (2002)


Antinociceptive effect of Melastoma malabathricum in mice.
Proceedings of 18th. Annual Seminar and Workshop, Malaysian
Natural Product Scciety. 94

150. Z Ahmad, SAS Sharifah Shazila and M. Nazrul Somchit (2002) Fish
oil enhanced caveolin expression in the wall of Aorta of cholesterol-
fed rabbits. Proceedings of 18th. Annual Seminar and Workshop,
Malaysian Natural Product Scciety. 97

151. M. Nazrul Somchit, Y Adam, Z Ahmad and MR Sulaiman (2002)


Anti-pyretic effect of the weed Imperata cylindrical in mice.
Proceedings of 18th. Annual Seminar and Workshop, Malaysian
Natural Product Scciety. 103

44
152. A. Azmahani, M. Nazrul Somchit, I. Elysha Nur and M.T. Zarani
(2001) Preliminary study on the fertility effect of Euphorbia hirta,
Cassia alata and Cassia tora extracts in female mice. Proceedings of
the 16th. Scientific Meeting of The Malaysian Society of Pharmacology
and Physiology. P1

153. I. Elysha Nur, M. Nazrul Somchit, I. Reezal and M. Abdul Rahim


(2001) In vitro anti-fungal and anti-bacterial properties of Cassia alata.
Proceedings of the 16th. Scientific Meeting of The Malaysian Society
of Pharmacology and Physiology. P3

154. I. Reezal, M. Nazrul Somchit, M. Abdul Rahim, M. Ruddy Hasmawie


and A. Murni (2001) Anti-microbial activity of Euphorbia hirta extract
in vitro. Proceedings of the 16th. Scientific Meeting of The Malaysian
Society of Pharmacology and Physiology. P4

155. M. Nazrul Somchit and M.H. Nur Shukriyah (2001) Analgesic, anti-
pyretic and anti-inflammatory properties of Zingiber zerumbet.
Proceedings of the 16th. Scientific Meeting of The Malaysian Society
of Pharmacology and Physiology. P2

156. S. Faizah, M. Nazrul Somchit and E.H. Gan (2001) In vitro effect of
Nonsteroidal anti-inflammatory drugs, Mafenamic acid and Piroxicam
on cancer cell lines. Proceedings of the 16th. Scientific Meeting of The
Malaysian Society of Pharmacology and Physiology. P36

157. A.R. Nor Shahida, M. Nazrul Somchit, F.Y. Foo and S. N. Chong
(2001) Hepatotoxicity induced by the anti-fungal drug, itraconazole
but not fluconazole in mice. Proceedings of the 16th. Scientific
Meeting of The Malaysian Society of Pharmacology and Physiology.
P18

158. Z. Ahmad, K.Y. Yeoh and M. Nazrul Somchit (2001) The effect of
vitamin E supplementation on caveolin in the wall of aorta of
hypercholesterolemic rabbits. Proceedings of the 16th. Scientific
Meeting of The Malaysian Society of Pharmacology and Physiology.
P29

159. M. Nazrul Somchit, J.G.Kenna and J. Caldwell (2000) Sulindac-


induced apoptosis: A potential mechanism for cancer therapy.
Proceedings of 3rd National Health Symposium. 355-360

160. M. Nazrul Somchit, J.G.Kenna and J. Caldwell (2000) Involvement of


Acyl Co-A ligases in the formation of Ibuprofen modified hepatic
proteins. 15th. Scientific Meeting of The Malaysian Society of
Pharmacology and Physiology. Orl 5.

161. M. Nazrul Somchit, Nor Shahida A. Rahman, Salam Abdullah (2000)


Toxicity of antifungal drug, Miconazole to rat hepatocytes: In vitro and

45
In vivo studies. Proceedings of the 6th National Conference on Medical
Sciences. 118

162. M. Nazrul Somchit, E. H. Gan, M. R. Sulaiman (2000) Hepatotoxicity


induced by the nonsteroidal anti-inflammatory drug Mefenamic Acid
(Ponstan) in mice: Histopathological investigation. Proceedings of
the 9th Scientific Conference of Electron Microscopy Malaysia. 115-
117.

163. M. Nazrul Somchit and E. H. Gan, (2000) Histopathological


evaluation on the effects of nonsteroidal anti-inflammatory drug
Mefenamic Acid (Ponstan) in kidneys of mice. Proceedings of the 9th
Scientific Conference of Electron Microscopy Malaysia. 140-142.

164. LA Ramsay, LT Wade, M. Nazrul Somchit, E Eliasson, AK Daly, C


Day, GJM Alexander, JG Kenna and J Caldwall (1999) Detection of
Circulating Anti-diclofenac antibodies in serum and Novel diclofenac
altered hepatic proteins in patients with diclofenac hepatitis. ISSX
Proceedings.(Budapest) 13, 75.

165. Rosly, S.M., Liang, J.B., Noordin, M.N., M. Nazrul Somchit, and
Jelan, Z.A. (1999). Total cyanogens in two varieties of local cassava
leaves. Proceeding of the National Congress on Animal Health and
Production, 3-5 September 1999, Melaka pp.205-208.

166. M. Nazrul Somchit, J.G.Kenna and J. Caldwell (1999) Hepatotoxicity


of rats treated with the nonsteroidal anti-inflammatory drug diclofenac
but not ibuprofen: Histological and blood parameters. Proceedings of
the 8th Scientific Conference of Electron Microscopy Malaysia. 191-
192.

167. J. Caldwell, M. Nazrul Somchit, L. Ramsay and J.G. Kenna (1998)


Inhibition of canalicular plasma membrane dipeptidyl peptidase IV
(DPP IV) is not associated with NSAID-induced hepatotoxicity in
rat. ISSX Proceedings. (Australia) 12, 98.

168. M. Nazrul Somchit, L.T. Wade, R.D. Goldin, L. Ramsay, J.G. Kenna
and J. Caldwell (1997) Hepatotoxicity in rats treated chronically with
the nonsteroidal anti-inflammatory drug diclofenac but not ibuprofen.
ISSX Proceedings. (Sweden) 1997, 11, 105.

46
IX. Consultancy

1. Chemical Engineering Pilot Plant, Faculty of Chemical and Natural


Resources Engineering, Universiti Teknologi Malaysia
Title: Production of Methyl Hydroxy Chalcone Polymer
(MCHP) and phytochemicals from Cinnamomum
zeylanicum
Funding: IRPA project (2002-2005)

2. Chemical Engineering Pilot Plant, Faculty of Chemical and Natural


Resources Engineering, Universiti Teknologi Malaysia
Title: Study of Methyl Hydroxy Chalcone Polymer (MCHP) as an
Insulin potentiating Activity (IPA) using in vitro cell culture
method
Funding: IRPA project (2002-2005)

3. Advisor for the Malaysian Society for Complementary Therapies


(MSCT) – 2005

4. Scientific Advisor for Complemantary Therapies Academy (Asia) Sdn.


Bhd. – 2005

5. Scientific Advisor for Holistic Care Iridology, Ipoh Perak

6. Scientific consultant for Pusat Sains dan Kreativiti Terengganu (PSKT)

7. Scientific advisor for “Pusat Rawatan Homeopati & Naturopati Ram”,


Cheras, Kuala Lumpur.

8. Scientific Consultant for Natural Terapy Centre, Penang.

47

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