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C A 39 year old primigravida has a fetal Down 4 Doppler ultrasound in high risk pregnancies is
syndrome risk of 1 5 0 following antenatal associated with a 30% reduction in perinatal mortality. I
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serum testing at 16 weeks gestation 5 Reduced amniotic fluid volume is associated Lvith
1 The age-related risk at 39 years is sufficiently high to
increased perinatal morbidity and mortality.
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warrant offering a primary invasive test as an option. 0
AUTHOR DETAILS
2 Second triinester ultrasound will identify all
pregnancies affected by Down syndrome. C Dr Devender Roberts M f K ~ h H MIICOG. Ixctiirer, I'niversity
llcpartment o f Ohstetric~ c9 Gynaecology. Liverpool Wonlen's
3 Screening based solely on the basis of EIospital. Crown Street. I.ivt.rpod 1.18 11.". I' K
amniocentesis for all women above the age of 35 years Professor James P Neilsen HSc $11) FIICO(;. I Inrvcrsitp 1)ep;rrtmenl
detects 50% of Down-affected pregnancies. El 01 Obsletrics c9 Gpnaecology, Liverpool Women's Hospital,
4 First trimester nuchal translucency screening in 1,iverpool.CK
combination with maternal age has high detection Correspondence to: I l r Devcncler Roberts
rates for aneuploidy and may also detect
pregnancies that are destined to miscarry. ri If you intend to claim CME credits, transfer your
5 Free P-hCG and PAPP-A are the two most answers to the enclosed CME answer sheet and
potent serum markers in the first trimester. L return it to the CME office at the College.