1: Oral Maxillofac Surg Clin North Am. 2004 Aug;16(3):333-54.

Links

Adenomatoid odontogenic tumor.

Rick GM.

Loma Linda University, School of Dentistry, Loma Linda, CA, USA; Scripps
Oral Pathology Service, 5190 Governor Drive, Suite 106, San Diego, CA 92122-
2848, USA.

PMID: 18088735 [PubMed - in process]

1: J Oral Pathol Med. 2007 Aug;36(7):383-93. Links

An updated clinical and epidemiological profile of

the adenomatoid odontogenic tumour: a
collaborative retrospective study.
Philipsen HP, Reichart PA, Siar CH, Ng KH, Lau SH, Zhang X, Dhanuthai
K, Swasdison S, Jainkittivong A, Meer S, Jivan V, Altini M, Hazarey V,
Ogawa I, Takata T, Taylor AA, Godoy H, Delgado WA, Carlos-Bregni R,
Macias JF, Matsuzaka K, Sato D, Vargas PA, Adebayo ET.

Edificio El Condór 30, Urb. Guadalmina Alta, San Pedro de Alcántara, Spain.

BACKGROUND: Adenomatoid odontogenic tumour (AOT) is a benign

odontogenic jaw lesion. The aim of this study was to update the biological
profile of AOT. MATERIAL AND METHODS: Cases published in the literature
and cases in files of co-authors were included. RESULTS: 550 new cases were
retrieved, and of a total of 1082 cases analysed, 87.2% were found in the second
and third decades. The M:F ratio was 1:1.9. 70.8% were of the follicular variant
(extrafollicular: 26.9%, peripheral: 2.3%). 64.3% occurred in the maxilla. 60%
of follicular AOTs were associated with unerupted canines. Nineteen cases of
AOT (2.8%, M:F ratio was 1:1.4) were associated with embedded third molars.
Twenty-two peripheral AOTs (2.3%, M:F ratio was 1:5.3) were recorded. The
relative frequency (RF) of AOT ranged between 0.6% and 38.5%, revealing a
considerably wider AOT/RF range than hitherto reported (2.2-7.1%).
CONCLUSIONS: This updated review based on the largest number of AOT
cases ever presented, confirms the distinctive, although not pathognomonic
clinicopathological profile of the AOT, its worldwide occurrence, and its
consistently benign behaviour.

1: J Oral Sci. 2002 Mar;44(1):13-7. Links

Differential diagnosis between dentigerous cyst

and benign tumor with an embedded tooth.
 Ikeshima A, Tamura Y.

Department of Radiology, Nihon University School of Dentistry at Matsudo,

Chiba, Japan. ikeshima@mascat.nihon-u.ac.jp

It has been generally recognized that the radiological appearances of cysts and
tumors related to an embedded tooth are similar. However, based on their
clinical experience, Abrams et al. pointed out that there was a difference
between the two lesions at the attachment point to the embedded tooth. To
investigate this difference, we conducted a study employing the radiographs of
patients who visited Nihon University Dental Hospital at Matsudo and were
pathologically defined as having a cyst or tumor. Using radiographs of these
patients, we investigated the attachment point to the embedded tooth, and
expressed the results as the proportion of the attachment point to the embedded
tooth root length. The study was carried out in 100 patients with cysts (87
dentigerous cysts and 13 odontogenic keratocysts), and 27 patients with benign
tumors (24 ameloblastomas and three adenomatoid odontogenic tumors). Prior
to treatment based on the numerical results, the distribution of the results was
examined. Thus, we evaluated several methods of examining the distributions,
and found the best method to be discriminant analysis. The results showed that
the discriminated boundary value (from the cemento-enamel junction) was 0.38
for the embedded tooth root length. The cases showing a boundary value of less
than 0.4 for the cemento-enamel junction were judged to be cysts, and those
showing a value of 0.4 or more were judged to be benign tumors. The rate of
misjudgement was 28% in the cyst group and 33.3% in the benign tumor group.

PMID: 12058865 [PubMed - indexed for MEDLINE]

1: Oral Oncol. 1999 Mar;35(2):125-31. Links

Adenomatoid odontogenic tumour: facts and

figures.
Philipsen HP, Reichart PA.

Abteilung für Oralchirurgie und zahnärztliche Röntgenologie, Zentrum für

Zahnmedizin, Universitätsklinikum Charite, Humboldt Universität, Berlin,
Germany.

The present profile of the adenomatoid odontogenic tumour represents an update

based on data collected from 1991 onwards. Our present knowledge discloses
the AOT being a benign (hamartomatous), slow growing lesion which occurs in
several intraosseous (follicular (F) and extrafollicular (EF)) and one peripheral
variant all having identical histology. The F and EF variants account for 96 per
cent of all AOT's of which 71 per cent are F variants alone. F and EF variants
together are more commonly found in the maxilla than in the mandible with a
ratio of 2.1:1. Age distribution shows that more than two thirds are diagnosed in
the second decade of life and more than half of the cases occur within the teens
(13-19 years of age). The female:male ratio for all age groups and AOT variants
together is 1.9:1. The marked female predominance (around 3:1) among certain
Asian populations needs further clarification. The distribution of unerupted
permanent teeth found in association with the F variant shows that all four
canines account for 59 per cent and the maxillary canines alone for 40 per cent.
Recent findings strongly indicate the AOT is derived from the complex system
of dental laminae or its remnants. Occurrence of areas of CEOT-like tissue in an
otherwise "classic" AOT should be considered a normal feature within the
continuous histomorphological spectrum of AOT. Immunohistochemical and
ultrastructural findings have revealed that the eosinophilic deposits or "tumour-
droplets" most probably represent some form of enamel matrix.

PMID: 10435145 [PubMed - indexed for MEDLINE]