Summary of Peer Reviewed Clinical Studies on Protandim

Complete studies available at Pubmed.gov – search “Protandim”

1. “The Induction of Human Superoxide Dismutase and Catalase in Vivo: A fundamentally New Approach to
Antioxidant Therapy, Free Radical Biology and Medicine (2006) University of Colorado
● Protandim completely eliminates the age-related increase in cell aging factors, oxidative stress.
● Reduces oxidative stress by a minimum of 40 percent - to the progressive aging rate of a 20 year old.
● Significantly increases activity of SOD and CAT antioxidant enzymes by 54 percent - substantially increasing the
body’s antioxidant defenses.

2. “Synergistic Induction of Heme Oxygenase-1 by the Components of an Antioxidant Supplement Protandim”, Free
Radical Biology and Medicine (2008) University of Colorado
● Protandim produces a 300 percent increase in glutathione, a key antioxidant and anti-aging factor.
● Protandim’s synergistic formulation provides more antioxidant power than any food or supplement.

3. “Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin
Carcinogenesis as a Model”, PLoS ONE Journal (2009) Louisiana State University
● Reduced tumor incidence by 33% and tumor multiplicity by 57%.
● Increased expression of antioxidant and anti-inflammatory enzymes.
● Overall, induction of antioxidant enzymes by Protandim may serve as a practical and potent approach for cancer
prevention.

4. “Chronic Pulmonary Artery Pressure Elevation is Insufficient to Explain Right Heart Failure”, American Heart
Association, Circulation 2009 Virginia Commonwealth University
● Protandim prevented the formation of scar tissue in the heart
● Prevented capillary loss in the heart muscle; prevented death of heart cells.
● Osteopontin levels reduced by more than 50%.
● Heart output was preserved and cardiac fibrosis prevented.

5. “The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis
during Skin Carcinogenesis”, PLoS ONE Journal (2010) Louisiana State University
● Protandim's ability to modulate relationship between superoxide dismutase and tumor suppressor p53 believed
responsible for reduction of skin cancers.
● Protandim's ability to increase production of the body's Nrf2-regulated protective genes, sometimes referred to
as "survival genes".

6. “The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress
in Muscular Dystrophy Mdx Mice”, Journal of Dietary Supplements (2010) Harvard Medical School, Mass General
Hospital
● 48% decrease in plasma TBARS, a marker of lipid peroxidation and oxidative stress.
● 57% decrease in plasma Osteopontin, a fibrosis-promoting factor linked to heart failure,

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 ● 35% increase in beneficial, protective plasma PON1 activity, an enzyme that protects against atherosclerosis by
preventing the oxidation of low-density lipoprotein (LDL) cholesterol.

7. “Protandim Attenuates Intimal Hyperplasia in Human Saphenous Veins Cultured ex vivo via a Catalase-Dependent
Pathway." Free Radical Biology and Medicine (2010) AHA, NIH, Ohio State University
● Protandim’s prevents the proliferation of cells that can cause re-blockage of vessels following coronary artery
bypass surgery, stenting, and carotid enarterectomy.
● Treatment with Protandim, reduced intimal proliferation to the level seen in a normal healthy saphenous vein.
PROTANDIM
A Promise of Protection
Founded in breakthrough science, developed after 40 years of research, featured on ABC, NBC, PBS, in The
Wall Street Journal, and described in CNN Chief Medical Correspondent Dr. Sanjay Gupta’s book “Chasing
Life”, Protandim is specially formulated to fight aging at the source. Protandim reduces aging at the cellular
level and has also been shown in scientific studies to activate the transcription factor Nrf2.
Protandim delivers a biochemical wake up call to every cell in your body.
Here’s how: You have several trillion cells in your body. When you take Protandim, it binds itself to your cells
and modifies the protein in your cells. It also sends a message to your DNA. Your DNA is comprised of 25,000
genes that are blueprints. They make every protein and enzyme in your body. Of these 25,000 genes, some are
Nrf2 genes.
As an Nrf2 activator, Protandim up-regulates or “turns on” 400-500 enzymes, including survival genes of all
kinds. Nrf2 is called the master regulator of survival genes.
Survival genes are stress response genes that enable your cells to get through tough times, including oxidative
stress, but also traumatic stress, such as when your cells, organs and blood vessels get injured.
The result? Increased production of protective genes called survival genes and decreased production of the
genes that can cause inflammation and scar tissue.
Independent research by Harvard, VCU, LSU and OSU, have validated this ability and measured
Protandim’s impact in tuning approximately 500 survival genes and what that means for our health and
our battle against age-related diseases, including cancer and heart disease. Additional studies are being
conducted on osteoarthritis, diabetes, HIV/AIDS, periodontal disease, asthma, reduced injury recovery rates,
neurodegenerative diseases like Parkinson’s and Alzheimer’s and many others.
Below are some of the genes regulated by Protandim, as demonstrated by seven published, peer-reviewed
clinical studies:
● Antioxidant enzymes increased over 40% - reducing oxidative stress and cellular aging
● Glutathione increased by 300% - antioxidant, blood booster, cell detoxifier
● Anti-inflammatory genes increased – reducing inflammation
● Anti-fibrotic genes increased – reducing scarring of the heart and lungs
● PON1 activity increased – protects against arteriosclerosis and oxidized LDL cholesterol
● P-53increased - a tumor suppressor gene
● Osteopontin reduced by 57%. – directly linked to a wide variety of cancers, autoimmune diseases, and
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 osteoporosis
● FABP-4 reduced by 85% - associated with multiple pro-inflammatory responses
● FABP -5 reduced by 66% - lowers likelihood of calcified arteries
● Akr1B10 increased - promotes cell survival

Protandim provides a remarkable promise of protection from all kinds of age-related diseases, unleashing the
power within our own bodies, which is the most powerful and safest first line of defense.
*Protandim is not intended to diagnose, treat, cure or prevent any disease.

Contact: Jason & Brooke Northrup

415.223.3965
www.SlowYourAging.info