STEVEN Z.

WHETZEL
3535 Eagles Hill Ridge, Saint Charles, Missouri 63303 (636)734-3272
Immediately Available US Citizen
Email:sw1d59c4@westpost.net / Portfolio URL: http://www.pharmagigs.com/WhetzelS
SELF-MOTIVATED INNOVATIVE BENCH LEVEL RESEARCH SCIENTIST SEEKING A NEW VENUE TO
IMPACT "REGARDLESS" OF POSITION LEVEL.
ABILITIES:
* Extensive experience in study design, data analysis, and surgical techniques i
n a highly regulated environment following SOPs, GLPs, FDA and USDA regulations
in multiple scientific disciplines within the pharmaceutical and agribusiness in
dustries with a focus on in vivo CNS biochemistry, behavioral models, and in vit
ro high throughput screening with advanced IT automation.
* Recognized ability to improve quality and focus of research by use of strong d
etail centric analytical skills and communicate complex issues with clarity to d
ifferent types of audiences.
* Provide department wide data processing efficiency with award winning advanced
IT automation.
* Increase staffing capabilities by training colleagues in experiment-related te
chniques.
* Manage quality assurance procedures and systems in a modern CNS In vivo Bioche
mistry Pharmaceutical R & D environment.
AREAS OF EXPERIENCE:

HPLC & Gas Chromatography Neurochemical & Behavioral Models CNS In Vivo Biochemi
stry
Mass Spectrometry Integrated Technology (IT) Neurological Dissection
Translatable Biomarker Identification Antibody Preparation In Vitro Binding
Pharmaceutical & Agribusiness Entomological Biochemistry Cell Culture
PROFESSIONAL EXPERIENCE:

PFIZER, Inc., Senior Research Scientist , 09/1986 - 04/2010

700 Chesterfield Parkway West; Chesterfield, Missouri 63017
(5 Internal Advancements, Rehire Optional)
Key Accomplishments:
* Led alternate indication preclinical / clinical bio-informatics analysis of co
mpound portfolio, resulting in an increase portfolio value, development timeline
reduction, by analysis of pre-clinical and clinical information contained in p
ublications retrieved from published scientific sources, technical literature,
internal investigator reports, and all internal documents then advance compounds
of interest for pre-clinical experimental evaluation followed by clinical studi
es, if warranted.
* Spearhead and manage experimental and summary operations of numerous pre-clini
cal CNS psychological disorder and pain drug discovery models. Knowledge of Good
Manufacturing Practices.
* Develop and optimize high throughput pre-clinical in vivo CNS neuro-chemical (
HPLC, MS, GC), multiple behavioral models, and in vitro RIAs, EIAs, and cell cul
ture models for fast, accurate, reliable, and cost effective compound evaluation
. Hands-on animal handling experience and familiarity with the types of models e
mployed in the evaluation of candidate drugs, including their endpoints, applica
tions, and limitations as well as skill in performing surgical procedures. Suppo
rt the CNS/Pain/Migraine discovery portfolio by providing behavioral and in vivo
neurochemical pharmacology support
* Increase staff productivity by training colleagues in in vivo neurosurgery and
other experiment related techniques, operation of HPLC CNS neuro-chemical syste
ms, animal behavioral / pain models, and advanced IT automation. Organize and co
ordinate QC activities being performed by co-workers.
* Led multiple, award winning, department wide integration technology projects w
hich greatly improved data processing efficiency. Received 12 IT Automation Reco
gnition Awards.
* Publishing history with 24 externally peer-reviewed articles, over 60 internal
ly-reviewed research reports, and 27 "Society of Neuroscience" presented posters
.
ADDITIONAL POSITIONS:
SYSTEMS DIGITAL, Computer Technical Consultant (Owner), 01/1991 - 12/2009
* Provide cost effective and timely IT support for small companies.
* Versed in Windows OS's (98, NT, XP, Vista, 7),MS Office(All components, Expert
in VB programming), numerous graphics packages(Photoshop, Prism, Sigmaplot) , w
eb authoring packages (Dreamweaver suite), and remote IT support. Navigating loc
al area network and utilizing relational databases and reporting tools.
* Experience using GraphPad Prism and SPSS statistical packages to run descripti
ve analyses.

UNITED STATES GRAIN MARKETING RESEARCH LAB (USDA-ARS), Biochemical Research Assi
stant,
09/1984 - 08/1986 (Federal, Dr. Okkyung Chung)
1515 College Ave., Manhattan, KS 66502
* Independently conducted grain lipid analysis and insect development research
using various technologies including high performance liquid chromatography, gas
chromatography, mass spectroscopy, Immuno-assay / ELISA, UV/Fluorescent analysi
s of proteins, and gel electrophoresis.
* Assisted in mainframe computer site installation at USGMRL.
KANSAS STATE UNIVERSITY, Biochemical Research Assistant,
11/1981- 09/1984 (Kansas State, Dr. Karl Kramer, Dr. Paul Kelly)
1515 College Ave., Manhattan, KS 66502
* Assisted in biochemical entomology research identifying key metabolic pathways
of the Manduca sexta.
* Developed rodent brain synaptic junction and synaptic plasma membrane isola
tion protocol for characterization of immunogens and coordinate development of p
olyclonal and monoclonal antibodies development using SDS-PAGE / Western blots.

EDUCATION & PROFESSIONAL TRAINING:

Bachelor of Science in Biochemistry & Chemistry
University of Wisconsin, Milwaukee, Wisconsin (07/1981)
Wallac Trilux Training in Finland
Waters HPLC Millennium and Empower Data Automation

SELECTED AWARDS & RECOGNITION:

Twelve (12) CNS Biology IT Pharmacology Automation Support Awards.
Special award for the developing microdialysis model at Warner-Lambert, now Pfiz
er.

CONFERENCES/MEETINGS:
Society For Neuroscience 1988 - 2009: Presented 27 poster(s),
Experimental Biology 2009
Dopamine 2002
Pitcon96
REFERENCES:
Archie (Archana) Chaudhry, Ph.D., Clinical Program Manager, Asterand, Inc.
TechOne Bldg. - Suite 501, 440 Burroughs, Detroit, MI, USA 48202-3420
Tel: (313) 263-0960 ext. 275, email: archana.chaudhry@asterand.com
Dr. Stevin Zorn, Exec. VP, R&D, Lundbeck Research USA, Inc, Lundbeck Internation
al
215 College Ave, Paramus, NJ 07652,
Mobile: (201) 218-3353, email: zorn@lundbeck.com
Dr. Hyacinth Akunne, CEO, JOAK American Home
1660 Pond Shore Dr., Ann Arbor, MI 48108
Tel: (734) 973-7764, email: hyakunne@comcast.net
CO-AUTHORED RESEARCH PUBLICATIONS
Preclinical Pharmacology of PF-03800130: A Novel Combined Dopamine D2 Receptor P
artial Agonist / Serotonin Transporter Reuptake Inhibitor (In Progress for Submi
ssion to JPET 2010)
Preferential Action of Gabapentin and Pregabalin at P/Q-Type Voltage-Sensitive C
alcium Channels:
Inhibition of K+-Evoked [3H]-Norepinephrine Release from Rat Neocortical Slices
(Synapse, 45:171-190 [2002])
The Discovery of PD89211 and Related Compounds: Selective Dopamine D4 Receptor A
ntagonists
(Progress in Neuro-Psychopharmacology & Biological Psychiatry, 26, 219-226 [2002
])
Neuropharmacological Profile of a Selective Sigma Ligand, Igmesine: A Potential
Antidepressant
(NeuroPharmacology, 41, 138-149 [2001])
PD 158771, A Potential Antipsychotic Agent with D2/D3 Partial Agonist and 5-HT1A
Agonist Actions, Neurochemical Effects, (Neuropharmacology, 39, 1197-1210, [20
00])
A Series of 6- and 7-Piperazinyl- and -Piperidinylmethylbenzoazinones with Dopam
ine D4 Antagonist Activity: Discovery of a Potential Atypical Antipsychotic Agen
t (J. Med. Chem., 42,25,5181-5187 [1999])
Aminopyridines with high affinity for both serotonin and dopamine receptors (J.M
ed Chem. 41,760-771, [1998])
Pharmacological Characterization of PD 152255, A Novel Dimeric Benzimidazole Dop
amine D3 Antagonist (Pharmacology Biochemistry and Behavior, 59, 2, 487-493, [19
98])
Reduction of 3,4-diaminopyridine- induced biogenic amine synthesis and release i
n rat brain by gabapentin (Psychopharmacology, 137, 74-80, [1998])
Isoindolinone Enantiomers Having Affinity For The Dopamine D4 Receptor (Bioorgan
ic & Medicinal Chemistry Letters, 8, 1499-1502, [1998])
Effects of the Dopamine D3 Antagonist PD 58491 and its Interaction with the Dopa
mine D3 Antagonist PD 128907 on Brain Dopamine Synthesis in Rat (Journal of Neur
ochemistry, 69, 2363-2368, [1997])
The Pharmacology of The Novel and Selective Sigma Ligand, PD 144418 (Journal of
Neuropharmacolgy, 36, 51-62, [1997])
3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as Dopamine D2 Partial Ag
onists and Autoreceptor Agonists (Journal of Medicinal Chemistry, 40, 2, 250-259
, [1996])
Agonist properties of a stable hexapeptide analog of neurotensin, N*MeArg-Lys-Pr
o-Trp-tLeu [NT(8-13)].
(Biochem. Pharmacol., 49, 1147-1154, [1995])
CI-1007, a dopamine autoreceptor agonist and potential antipsychotic agent. I. N
eurochemical Effects.
(The Journal of Pharmacology and Experimental Therapeutics 274, 898-911, [1995])
Neurochemical and functional characteristics of the preferentially selective dop
amine D3 agonist PD 128907. (The Journal of Pharmacology and Experimental Therap
eutics 275,1355-1366, [1995])
Differential Effects of the Nonpeptide Neurotensin Antagonist, SR 48692, on the
Pharmacological Effects of Neurotensin Agonists. (Peptides, 16, 37-44, [1995])
Pharmacological Profile Of The Dopamine Partial Agonist, (+/-)-PD128483 And Its
Enantiomers. (The Journal Pharmacology and Experimental Therapeutics, 266, 1177-
1189, [1993])
Biochemical and Pharmacological Characterization of PD118717 a Putative Piperazi
nyl Benzopyran
Dopamine Autoreceptor Agonist. (The Journal of Pharmacology and Experimental The
rapeutics, 263, 1147-1158, [1992])
Evaluation of a Series of Tetrahydropyridine Oximes as High Affinity Sigma Ligan
ds and Pharmacological Characterization of PD 128298, an apparent Selective Sigm
a Ligand: in Multiple Sigma and PCP Receptor Ligands: Mechanisms for Neuromod
ulation and Neuroprotection? (J.M. Kamenka and E.F. Domino, eds. NPP Books, Ann
Arbor, p.117-135, [1992])
In Vivo Effects of Tacrine (9-Amino-1,2,3,4- Tetrahydroacridine, THA) on Rat Bra
in Cholinergic and Monoaminergic Neurotransmission. Pharmacologist (30, No. 3, A
25, 1988)
Lipid and Bread Making Characteristics of German Winter and Spring Wheats. (The
American Association of Cereal Chemists, Cereal Chemistry, [1986])
Lipid-Protein Interactions in Wheat Flour, Dough, Gluten, and Protein Fractions.
(The American Association of Cereal Chemists, [1986])
Properties of Tyrosinase and Dopa Quinone Imine Conversion Factor from Pharate P
upal Cuticle of
Manduca Sexta L. (Insect Biochemistry 14, 4, 463-472, [1984])
PROFESSIONAL (LinkedIn) RECOMMENDATIONS
From: Archie (Archana) Chaudhry, Ph.D., Clinical Program Manager at Asterand, I
nc.
Email: archana.chaudhry@asterand.com
Dated: January 3, 2010
Details of the Recommendation: I am delighted to provide a reference for Steve
Whetzel. I interacted with Steve during my tenure at Pfizer where Steve was a s
enior scientist in Central Nervous System (CNS) Biology. Steve was an extremely
valuable member of an ADHD drug discovery team on which I served as the biology
project leader. Steve is an excellent neuroscientist and was instrumental in d
esigning and executing key experiments that helped advance the project to import
ant milestones and led to the identification of two lead compounds. His efforts
also helped us with human dose projection strategies. Steve worked well under p
ressure and always met deadlines. Steve is a team player and used to interactin
g with personnel from different lines and departments in a matrix environment.
Apart from the above project, Steve helped teams advance other CNS drug discover
y projects by coordinating research activities across multiple groups such as bi
ology, chemistry, pharmacodynamics and safety. He is well liked by his peers an
d goes the extra mile to help teams achieve their goals. In addition, Steve has
excellent verbal, written and presentation skills. Apart from his laboratory sk
ills, Steve also helped the CNS department with numerous IT-related initiatives
such as implementation of data automation, electronic notebook and numerous comp
uter modernization projects. In summary, Steve would be a valuable asset to any
organization.
From: Peter Boxer, VP Development at OtoMedicine
Email: peter_a_boxer@yahoo.com
Dated: March 19, 2009
Details of the Recommendation: I have had the privilege of knowing Steve for man
y years at Pfizer/Parke-Davis. He has a very strong work ethic and is very detai
l oriented. He has great knowledge of the science, technical details of the equi
pment, and data analysis. He also has tremendous computer expertise. I strongly
recommend him with no reservations.
From: Charlie Taylor, Former Pfizer Research Fellow
Email: taylor.charles54@gmail.com
LinkedIn: http://www.linkedin.com/in/charlietaylor
Date: March 18, 2010.
Details of the Recommendation: Steven is a great colleague. He is very hard work
ing, unusually conscientious, and just a plain nice guy. For years, he has run a
technically challenging brain monoamine analysis lab that has made many solid c
ontributions to drug discovery. He also is very accomplished at computer program
ming, maintenance and security. He has been quite flexible in the most recent co
uple of years, changing job goals with corporate reorganization. Finally, he is
a truly thoughtful person, who is quick to be generous with time or other resour
ces to help others. I couldn't recommend him for future jobs more strongly.
From: Desiree Watson, Former Senior Scientist, Pfizer Pharmaceuticals
Email: bellades@comcast.net
LinkedIn: http://www.linkedin.com/pub/desiree-watson/3/779/334
Date: March 18, 2010
Details of the Recommendation: I worked with Steve for about 7 years at Pfizer.
He is an amazing scientist, and a great person who is fun to work with. His know
ledge was the backbone of the research we did in our lab, and he was always will
ing to teach others. I truly miss working with him.
From: Mike Barratt, Sr. Director, Pfizer Pharmaceuticals
LinkedIn: http://www.linkedin.com/pub/mike-barratt/3/ba9/bb3
Date: March 25, 2010
Details of the Recommendation: Steven is a hardworking, experienced and talented
scientist and technologist who is constantly looking to bring new ideas to the
table to develop. He thrives in a team environment and is passionate about his s
cience. He enjoys discussing his data and seeking input from others to test out
his thinking or improve the experimental plan. Steve is detail oriented and can
be relied upon to follow through on commitments - a pleasure to work with.
From: Christopher Moore, Former Senior Associate Scientist, Pfizer Pharmaceutic
als (colleague)
LinkedIn: http://www.linkedin.com/in/cmooretitle21usc
Date: March 27, 2010
Details of the Recommendation: Steve and I were colleagues in the neuroscience d
epartment at Pfizer for 10 years. Steve is an excellent scientist, IT expert and
team player. I worked on several projects with Steve and his scientific contrib
utions were always invaluable. Even more invaluable was Steve's IT expertise. St
eve was the go-to guy in the department for all IT issues. His knowledge of our
desktop, bench-top, and company specific systems and applications was superior t
o that of the official company IT support. Steve's IT support was an indispensab
le resource.
From: Len Cooke, Former Research Scientist, Pfizer Pharmaceuticals
LinkedIn: http://www.linkedin.com/pub/len-cooke/3/b17/25a
Date: March 25, 2010
Details of the Recommendation: Steve and I worked together for approximately 20
years at Warner Lambert / Pfizer. We shared ideas on several different projects
and his input was invaluable. However, it was always Steve's IT experience that
the entire department most appreciated. We were lucky to have someone with his k
nowledge at our fingertips to solve IT problems. Instead of waiting, what could
be days for someone in the IT group to work with us, Steve was there when needed
, often with better solutions than those in the IT group. I will always be grate
ful he would drop what he was doing to make my job easier.
From: Robert Durham, Former Senior Principal Scientist (Immediate Supervisor) at
Pfizer Pharmaceuticals.
Email: durham420@sbcglobal.net
Date: April 2, 2010
Details of the Recommendation: Steven is a thoughtful and detail oriented scient
ist who produces very high quality work and often offers creative solutions to p
roblems he encounters. During my time as his supervisor in the Neuroscience depa
rtment at Pfizer Steven made many significant contributions. He is particularly
adept at visual basic and data manipulation using Excel macros. In one particula
r instance he was able to write a data reduction protocol using Microsoft Excel
that largely automated data import and analysis associated with a complex behavi
oral assay. This solution dramatically reduced the time spent on manual data inp
ut and decreased the chance for errors. I hold Steven in very high regard and gi
ve him my highest recommendation for any future endeavors.
From: Noel Ramsey, Sr. Assoc. Sci., LVT, LATG, Pfizer (colleague, worked directl
y with)
Email: velvetskymalsam@yahoo.com
Date: April 13, 2010
Details of the Recommendation: Steve has many fine qualities! What I truly appre
ciated about Steve was that, "He was always there". Whenever I needed assistance
with an experiment, a computer crisis or statistical analysis, Steve was always
 there to lend a hand. You can't ask for a more loyal employee, colleague, and f
riend. He is an excellent scientist and can accomplish a great deal of work in a
short period of time! He would be an excellent addition to any drug discovery t
eam!
From: Lawrence Fitzgerald (Senior to and indirectly supervised Senior Scientist
at Pfizer Pharmaceuticals.)
Email: lwfitzge@gmail.com
Date: April 20, 2010
Details of the Recommendation: Steve is a talented and dedicated neurochemist th
at delivered high quality and timely data to neuroscience discovery project team
s. I could always count on Steve to do what was necessary to support my teams an
d help drive their success. Steve would be a great asset to any drug discovery o
r biotechnology team requiring strong, high energy analytic capabilities.
From: Steven Roberds (Associate Research Fellow at Pfizer Pharmaceuticals.)
Email: steven.l.roberds@pfizer.com
Date: May 20, 2010
Details of the Recommendation: "Steve is a highly skilled in vivo neuroscientist
who really knows his way around the brain. I worked with Steve nearly three yea
rs on multiple projects, and his expertise in neurophysiology, neuropharmacology
, and neuroanatomy were critical for our team. He enjoys and is good at learning
new technologies from others or from the literature. Steve has high standards f
or quality of experimental execution, including his own experiments. You can tru
st that Steve will design and execute a rigorous study and that the data are of
the highest quality."