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Pathophysiology

Risk Factors:
>Thymic hyperplaisia
>Under medication
Etiology: >Gender
Autoimmune >Age

Antibody production

Destruction of Acetylcholine receptor sites

Decrease Muscle Stimulation

Generalized Muscle Weakness

Laryngeal & pharyngeal muscle involvement Weakness of intercostals and Weakness of the face
diaphragm muscles
Cannot manage coughing
↓ Rib cage expansion
and swallowing
Muscle of chewing
↓ Expiratory effort are weak
Poor nutrition and risk for
aspiration Impairment of fine and Forced to stop
Air trapped in the lungs
gross motor movement eating
stridor
Hypoventilation Inability to groom and
feed self Wt. loss
Air hunger

Impaired diffusion
Fatigue

Reduced oxygenation Hypercapnia


Diplopia
↓ Arterial O2 level Ptosis
Depressed CNS function Bland facial
Respiratory acidosis expression
Air hunger

↑pulse and RR Systemic vasodilation Depressed respiratory


↑RR center
Dyspnea
Cyanosis Heart failure ↓ RR
Tachycardia
Hypertension
Reducing dyspnea
↓LOC

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