BRAND NAME: ADAPIN

GENERIC NAME: DOXEPIN

DRUG CLASS: ANTIDEPPRESANT
INDICATIONS: DOSAGE: ADVERSE CONTRAINDICATIONS: NURSING
REACTIONS: RESPONSIBILITIES:

The drug treatment of: The optimum daily Drowsiness, fatigue,

1. Psychoneurotic dosage of doxepin excitement, agitation, Doxepin is contraindicated Patients should be
depends on the restlessness, insomnia,
patients with anxiety in individuals who have warned that the effects
condition which is nightmares, hypomania,
and/or depressive being treated and the anxiety, confusion, shown hypersensitivity to of other drugs acting on
response of the disorientation, disturbed
reactions. Anxiety the drug or to other the central nervous
individual. Some concentration,
neurosis associated with patients respond delusions, dibenzoxepin compounds. system, such as alcohol,
promptly; others may hallucinations,
somatic disorders; barbiturates and other
not respond for 2 weeks activation of latent
Children:
alcoholic patients with or longer. An initial psychosis. CNS depressants, may
dosage of 25 mg 3 It is not recommended for
anxiety and/or be potentiated by
times daily may be used
use in children since safety
depression. 2. Psychotic in most patients. This doxepin.
dosage should be and efficacy in this age
depression, including increased as required by
group have not been The possibility of
manic-depressive illness 25 mg increments at
appropriate intervals established. suicide in seriously
(depressed type) and until a therapeutic
depressed patients may
involutional response is obtained.
Because of its
The usual optimum remain until significant
melancholia dosage range is 100 to anticholinergic activity
remission occurs. Such
150 mg per day. In
doxepin should not be
some patients, up to 300 patients should be
mg per day may be administered to patients
closely supervised
required, but there is
with a history of
rarely any benefit to be throughout therapy and
obtained by increasing glaucoma, increased
consideration should be
this dosage. In elderly
intraocular pressure or
patients it is advisable given to the possible
to proceed more urinary retention.
need for hospitalization.
cautiously with dosage
increments and to This type of patient
Tricyclic agents are
initiate treatment with a generally contraindicated should not have easy
lower dosage.
during the acute recovery access to large quantities
phase following of doxepin.
myocardial infarction and
in the presence of acute
congestive heart failure, as
well as in patients with a
history of blood dyscrasias
and severe liver disease.

Doxepin should not be

administered
concomitantly with MAO
inhibitors, since such a
combination may cause a
syndrome of intensive
sympathetic stimulation.
Drugs of this type should
be discontinued at least 2
weeks before instituting
therapy with doxepin.