Dengue fever

From Wikipedia, the free encyclopedia

Jump to: navigation, search "Dengue Fever" redirects here. For the band of the same name, see Dengue Fever (band). Dengue virus

A TEM micrograph showing Dengue virus virions (the cluster of dark dots near the center).

Virus classification Group: Group IV

((+)ssRNA)

Family: Flaviviridae Genus: Flavivirus Species: Dengue virus

Dengue fever
Classification and external resources ICD-10 ICD-9 DiseasesDB MedlinePlus eMedicine MeSH A90. 061 3564 001374 med/528 C02.782.417.214

Dengue fever (pronounced UK: /de/, US: /di/) and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics, and caused by four closely related virus serotypes of the genus Flavivirus, family Flaviviridae.[1] It is also known as

breakbone fever. The geographical spread includes northern Australia, northern Argentina, and the entire Singapore, Malaysia, Taiwan, Thailand, Cambodia, Vietnam, Indonesia, Honduras, Costa Rica, Panama, Paraguay[2], Philippines, Pakistan, India, Sri Lanka, Bangladesh, Mexico, Suriname, Dominican Republic, Puerto Rico, Jamaica, Bolivia[3], Brazil, Guyana, Venezuela, Barbados, Trinidad and Samoa[4]. Unlike malaria, dengue is just as prevalent in the urban districts of its range as in rural areas. Each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day.[5] The WHO says some 2.5 billion people, two fifths of the world's population, are now at risk from dengue and estimates that there may be 50 million cases of dengue infection worldwide every year. The disease is now epidemic in more than 100 countries.[6]

Contents
[hide]

1 Diagnosis 2 Etiology 3 Treatment o 3.1 Traditional and emerging treatments 4 Epidemiology 5 Prevention o 5.1 Vaccine development o 5.2 Mosquito control o 5.3 Potential antiviral approaches 6 Etymology 7 History 8 Use as a biological weapon 9 External links 10 See also 11 References

edit] Diagnosis

The diagnosis of dengue is usually made clinically. The classic picture is high fever with no localising source of infection, a petechial rash with thrombocytopenia and relative leukopenia - low platelet and white blood cell count. Care has to be taken as diagnosis of DHF can mask end stage liver disease and vice versa. 1. Fever, bladder problem, constant headaches, eye pain, severe dizziness and loss of appetite. 2. Hemorrhagic tendency (positive tourniquet test, spontaneous bruising, bleeding from mucosa, gingiva, injection sites, etc.; vomiting blood, or bloody diarrhea) 3. Thrombocytopenia (<100,000 platelets per mm or estimated as less than 3 platelets per high power field) 4. Evidence of plasma leakage (hematocrit more than 20% higher than expected, or drop in haematocrit of 20% or more from baseline following IV fluid, pleural effusion, ascites, hypoproteinemia) 5. Encephalitic occurrences. Dengue shock syndrome is defined as dengue hemorrhagic fever plus:

Weak rapid pulse, Narrow pulse pressure (less than 20 mm Hg) Cold, clammy skin and restlessness.

A dependable immediate information of the Dengue diagnostics in the rural areas can be performed by the introduction of Rapid Diagnostic Test kits which also differentiates between primary and secondary dengue infections. [7] Serology and polymerase chain reaction (PCR) studies are available to confirm the diagnosis of dengue if clinically indicated. Dengue can be a life threatening fever.

[edit] Etiology
Dengue fever is caused by Dengue virus (DENV), a mosquito-borne flavivirus. DENV is a ssRNA positive-strand virus of the family Flaviviridae; genus Flavivirus. There are four serotypes of DENV. The virus has a genome of about 11000 bases that codes for three structural proteins, C, prM, E; seven nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5; and short non-coding regions on both the 5' and 3' ends.[8]

[edit] Treatment

The mainstay of treatment is timely supportive therapy to tackle shock due to hemoconcentration and bleeding. Close monitoring of vital signs in critical period (between day 2 to day 7 of fever) is critical. Increased oral fluid intake is recommended to prevent dehydration. Supplementation with intravenous fluids may be necessary to prevent dehydration and significant concentration of the blood if the patient is unable to maintain oral intake. A platelet transfusion is indicated in rare cases if the platelet level drops significantly (below 20,000) or if there is significant bleeding. The presence of melena may indicate internal gastrointestinal bleeding requiring platelet and/or red blood cell transfusion. Aspirin and non-steroidal anti-inflammatory drugs should be avoided as these drugs may worsen the bleeding tendency associated with some of these infections. Patients may receive paracetamol preparations to deal with these symptoms if dengue is suspected.[9]

[edit] Traditional and emerging treatments

Emerging evidence suggests that mycophenolic acid and ribavirin inhibit dengue replication. Initial experiments showed a fivefold increase in defective viral RNA production by cells treated with each drug.[10] In vivo studies, however, have not yet been done. Unlike HIV therapy, lack of adequate global interest and funding greatly hampers the development of a treatment regime. In Brazilian traditional medicine, dengue is treated with cat's claw herb, which is for inflammation and does not prevent dengue.[11] In Malaysia, dengue is treated by some using natural medicine. Mas Amirtha and Semalu developed by the Alternative Medicine Research Institute, Center for Asia.[citation needed] The treatment is speculated to be able to arrest and reverse the viral infection and prevent the disease from advancing into a critical stage, though no evidence has yet shown effectiveness. In Philippines dengue patients use tawa-tawa herbs and sweet potato tops juice to increase the platelets counts and revived the patients.[citation needed]

[edit] Epidemiology

Worldwide dengue distribution, 2006. Red: Epidemic dengue. Blue: Aedes aegypti. Dengue is transmitted by Aedes mosquitoes, particularly A. aegypti and A. albopictus. Dengue may also be transmitted via infected blood products (blood transfusions, plasma, and platelets), but the scale of this problem is unknown.[12]

Worldwide dengue distribution, 2000. The first recognized Dengue epidemics occurred almost simultaneously in Asia, Africa, and North America in the 1780s, shortly after the identification and naming of the disease in 1779. A pandemic began in Southeast Asia in the 1950s, and by 1975 DHF had become a leading cause of death among children in the region. Epidemic dengue has become more common since the 1980s. By the late 1990s, dengue was the most important mosquito-borne disease affecting humans after malaria, with around 40 million cases of dengue fever and several hundred thousand cases of dengue hemorrhagic fever each year. Significant outbreaks of dengue fever tend to occur every five or six months. The cyclical rise and fall in numbers of dengue cases is thought to be the result of seasonal cycles interacting with a short-lived cross-immunity[clarification needed] for all four strains in people who have had dengue. When the cross-immunity wears off the population is more susceptible to transmission whenever the next seasonal peak occurs. Thus over time there remain large numbers of susceptible people in affected populations despite previous outbreaks due to the four different serotypes of dengue virus and the presence of unexposed individuals from childbirth or immigration. There is significant evidence, originally suggested by S.B. Halstead in the 1970s, that dengue hemorrhagic fever is more likely to occur in patients who have secondary infections by another one of dengue fever's four serotypes. One model to explain this process is known as antibody-dependent enhancement (ADE), which allows for increased

uptake and virion replication during a secondary infection with a different strain. Through an immunological phenomenon, known as original antigenic sin, the immune system is not able to adequately respond to the stronger infection, and the secondary infection becomes far more serious.[13] This process is also known as superinfection.[14][15] Reported cases of dengue are an under-representation of all cases when accounting for subclinical cases and cases where the patient did not present for medical treatment. There was a serious outbreak in Rio de Janeiro in February 2002 affecting around one million people and killing sixteen. On March 20, 2008, the secretary of health of the state of Rio de Janeiro, Srgio Crtes, announced that 23,555 cases of dengue, including 30 deaths, had been recorded in the state in less than three months. Crtes said, "I am treating this as an epidemic because the number of cases is extremely high." Federal Minister of Health, Jos Gomes Temporo also announced that he was forming a panel to respond to the situation. Cesar Maia, mayor of the city of Rio de Janeiro, denied that there was serious cause for concern, saying that the incidence of cases was in fact declining from a peak at the beginning of February. [16] By April 3, 2008, the number of cases reported rose to 55,000 [17] In Singapore, there are 4,0005,000 reported cases of dengue fever or dengue haemorrhagic fever every year. In the year 2004, there were seven deaths from dengue shock syndrome[18]. An epidemic broke out in Bolivia in early 2009, in which 18 people have died and 31,000 infected. An outbreak of dengue fever was declared in Cairns, located in the tropical north of Queensland, Australia on 1 December 2008. As at 3 March 2009 there were 503 confirmed cases of dengue fever, in a residential population of 152,137. Outbreaks were subsequently declared the neighbouring cities and towns of Townsville (outbreak declared 5 January 2009), Port Douglas (6 February 2009), Yarrabah (19 February 2009), Injinoo (24 February 2009), Innisfail (27 February 2009) and Rockhampton (10 March 2009). There have been occurrences of dengue types one, two, three and four in the region. March 4 2009, Queensland Health had confirmed an elderly woman had died from dengue fever in Cairns, in the first fatality since the epidemic began last year. The statement said that although the woman had other health problems, she tested positive for dengue and the disease probably contributed to her death. In 2009, in Argentina, a dengue outbreak was declared the northern provinces of Chaco, Catamarca, Salta, Jujuy, and Corrientes, with over 9673 cases reported as of April 11, 2009 by the Health Ministry [1]. Some travelers from the affected zones have spread the fever as far south as Buenos Aires [2]. Major efforts to control the epidemic in Argentina are focused on preventing its vector (the Aedes mosquitoes) from reproducing. This is addressed by asking people to dry out all possible water reservoirs from where mosquitoes could proliferate (which is, in other countries, known as "descacharrado"). There have also been information campaigns concerning prevention of the dengue fever;

and the government is fumigating with insecticide in order to control the mosquito population.[19] The first cases of dengue are currently being reported on the island of Mauritius, in the indian ocean. One of the South Asian country still highly suffering from this problem is Sri Lanka. [20]

[edit] Prevention
[edit] Vaccine development
There is no commercially available vaccine for the dengue flavivirus. However, one of the many ongoing vaccine development programs is the Pediatric Dengue Vaccine Initiative which was set up in 2003 with the aim of accelerating the development and introduction of dengue vaccine(s) that are affordable and accessible to poor children in endemic countries.[21] Thai researchers are testing a dengue fever vaccine on 3,0005,000 human volunteers after having successfully conducted tests on animals and a small group of human volunteers.[22] A number of other vaccine candidates are entering phase I or II testing.[23]

[edit] Mosquito control

A field technician looking for larvae in standing water containers during the 1965 Aedes aegypti eradication program in Miami, Florida. In the 1960s, a major effort was made to eradicate the principal urban vector mosquito of dengue and yellow fever viruses, Aedes aegypti, from southeast United States. Primary prevention of dengue mainly resides in mosquito control. There are two primary methods: larval control and adult mosquito control.[citation needed] In urban areas, Aedes mosquitos breed on water collections in artificial containers such as plastic cups, used tires, broken bottles, flower pots, etc. Periodic draining or removal of artificial containers is the most effective way of reducing the breeding grounds for mosquitos.[citation needed] Larvicide treatment is another effective way to control the vector larvae but the larvicide chosen should be long-lasting and preferably have World Health Organization clearance for use in drinking water. There are some very effective insect growth regulators (IGRs) available which are both safe and long-lasting (e.g. pyriproxyfen). For reducing the adult mosquito load, fogging with insecticide is somewhat effective.[citation needed]

Prevention of mosquito bites is another way of preventing disease. This can be achieved by using insect repellent, mosquito traps or mosquito nets. In 1998, scientists from the Queensland Institute of Medical Research (QIMR) in Australia and Vietnam's Ministry of Health introduced a scheme that encouraged children to place a water bug, the crustacean Mesocyclops, in water tanks and discarded containers where the Aedes aegypti mosquito was known to thrive.[24] This method is viewed as being more cost-effective and more environmentally friendly than pesticides, though not as effective, and requires the continuing participation of the community.[25] Even though this method of mosquito control was successful in rural provinces, not much is known about how effective it could be if applied to cities and urban areas. The Mesocyclops can survive and breed in large water containers, but would not be able to do so in small containers of which most urban area have within their homes. Also, Mesocyclops are hosts for the guinea worm, a pathogen that causes a parasite infection, and so this method of mosquito control cannot be used in countries that are still susceptible to the guinea worm. The biggest dilemma with Mesocyclops is that its success depends on the participation of the community. This idea of a possible parasite bearing creature in household water containers dissuades people from continuing the process of inoculation, and without the support and work of everyone living in the city, this method would not be successful.[26] In 2004, scientists from the Federal University of Minas Gerais, Brazil, discovered a fast way to find and count mosquito population inside urban areas. The technology, named Intelligent Monitoring of Dengue (in Portuguese), uses traps with kairomones that capture Aedes gravid females, and upload insect counts with a combination of cell phone, GPS and internet technology. The result is a complete map of the mosquitoes in urban areas, updated in real time and accessible remotely, that can inform control methodologies.[27] The technology was recognized with a Tech Museum Award in 2006.
[28]

In 2009, scientists from the School of Integrative Biology at The University of Queensland revealed that by infecting Aedes mosquitos with the bacterium Wolbachia, the adult lifespan was reduced by half. [29] In the study, super-fine needles were used to inject 10,000 mosquito embryos with the bacterium. Once an insect was infected, the bacterium would spread via its eggs to the next generation. A pilot release of infected mosquitoes could begin in Vietnam within three years. If no problems are discovered, a full-scale biological attack against the insects could be launched within five years. [30]

[edit] Potential antiviral approaches

Dengue virus belongs to the family Flaviviridae, which includes the hepatitis C virus, West Nile and Yellow fever viruses among others. Possible laboratory-based modification of the yellow fever vaccine YF-17D to target the dengue virus via chimeric replacement has been discussed extensively in scientific literature.[31] To date, however, no full scale studies have been conducted.[32]

In 2006, a group of Argentine scientists discovered the molecular replication mechanism of the virus, which could be specifically attacked by disrupting the viral RNA polymerase.[33] In cell culture[34] and murine experiments,[35][36] morpholino antisense oligos have shown specific activity against Dengue virus. In 2007 scientists' attenuated virus replication by interfering with activity of the dengue viral protease;[37] subsequently, a project to identify novel protease disruption mechanisms has been launched.

[edit] Etymology
The origins of the word dengue are not clear, but one theory is that it is derived from the Swahili phrase "Ka-dinga pepo", which describes the disease as being caused by an evil spirit.[38] The Swahili word "dinga" may possibly have its origin in the Spanish word "dengue" meaning fastidious or careful, which would describe the gait of a person suffering the bone pain of dengue fever.[39] Alternatively, the use of the Spanish word may derive from the similar-sounding Swahili.[40] Also known as "Dandy Fever", slaves in the West Indies who contracted dengue were said to have the posture and gait of a dandy. [41]

[edit] History
The first recorded potential case of dengue fever comes from a Chinese medical encyclopedia from the Jin Dynasty (265420 AD). The Chinese referred to a water poison associated with flying insects. [40] The first definitive case report dates from 1789 and is attributed to Benjamin Rush, who coined the term "breakbone fever" because of the symptoms of myalgia and arthralgia.[42] The viral etiology and the transmission by mosquitoes were deciphered only in the 20th century. Population movements during World War II spread the disease globally. A pandemic of dengue began in Southeast Asia after World War II and has spread around the globe since then.[43]

[edit] Use as a biological weapon

Dengue fever was one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its biological weapons program.[44]

[edit] External links

Dengue: CDC home page The Centers for Disease Control and Prevention (CDC) Dengue: Clinical and Public Health Aspects The Centers for Disease Control and Prevention (CDC)

Dengue haemorrhagic fever: diagnosis, treatment, prevention and control 2nd edition. Geneva : World Health Organization. The NCBI Virus Variation Resources The Virus Variation Resources at The National Center for Biotechnology Information (NCBI). See also [45]

[edit] See also

Brazilian research study (in Portuguese) using Cats claw against dengue Dengue fever at the Open Directory Project Dengue Virus Genomes database search results from the Dengue Virus Database at the Viral Bioinformatics Resource Center Discovering Dengue Drugs Together, a distributed computing project attempting to identify drug leads with broad spectrum activity against dengue.[46] Dengue fever in Brazil (slide show, in English and Portuguese) Dengue Fever Alliance - Todos Frente al Dengue Alliance to strengthen the capacity of action and management for A World Free of Dengue Fever

[edit] References
1. ^ "Chapter 4, Prevention of Specific Infectious Diseases". CDC Traveler's Health: Yellow Book. http://www2.ncid.cdc.gov/travel/yb/utils/ybGet.asp? section=dis&obj=dengue.htm. Retrieved 2007-05-20. 2. ^ Reuters, "Dengue Fever Hits Paraguay", New York Times" (March 4, 2007) 3. ^ "Dengue fever outbreak in Bolivia". BBC. 2009-02-03. http://news.bbc.co.uk/2/hi/americas/7866908.stm. Retrieved 2009-02-26. 4. ^ http://www.samoalivenews.com/Health/Dengue-Fever-Outbreak-Confirmed-InSamoa.html 5. ^ Dengue Fever Information Sheet. World Health Organization, October 9, 2006. Retrieved on 2007-11-30. 6. ^ Dengue epidemic threatens India's capital 7. ^ Such diagnostic kits may consist of a 'test cassette' or other device, of which the link is one example of many: "Dengue fever rapid test devices, also known as one-step dengue tests, are a solid phase immuno-chromatographic assay for the rapid, qualitative and differential detection of dengue IgG and IgM antibodies to dengue fever virus in human serum, plasma or whole blood." Atlas Link Biotech co. Ltd (2008)Dengue Fever Rapid Test Kits. Accessed: 27/06/09. Available at: http://www.ivdpretest.com/Dengue-Rapid-Tests.html 8. ^ Hanley, K.A. and Weaver, S.C. (editors) (2010). Frontiers in Dengue Virus Research. Caister Academic Press. ISBN 978-1-904455-50-9. 9. ^ "Dengue & DHF: Information for Health Care Practitioners". Dengue Fever. CDC Division of Vector-Borne Infectious Diseases (DVBID). 2007-10-22. http://www.cdc.gov/NCIDOD/dvbid/dengue/dengue-hcp.htm. Retrieved 2008-1005. 10. ^ Takhampunya R, Ubol S, Houng HS, Cameron CE, Padmanabhan R (2006). "Inhibition of dengue virus replication by mycophenolic acid and ribavirin". J.

Gen. Virol. 87 (Pt 7): 194752. doi:10.1099/vir.0.81655-0. PMID 16760396. http://vir.sgmjournals.org/cgi/content/full/87/7/1947. 11. ^ Brazil Scientists Discover "Cat's Claw" Combats Dengue Fever 12. ^ Wilder-Smith A, Chen LH, Massad E, Wilson ME (2009). "Threat of dengue to blood safety in dengue-endemic countries". Emerg Infect Dis 15 (1): 811. doi:10.3201/eid1501.071097. PMID 19116042. 13. ^ Rothman AL (2004). "Dengue: defining protective versus pathologic immunity". J. Clin. Invest. 113 (7): 94651. doi:10.1172/JCI200421512. PMID 15057297. 14. ^ Nowak MA, May RM (January 1994). "Superinfection and the evolution of parasite virulence". Proceedings. Biological sciences / the Royal Society 255 (1342): 819. doi:10.1098/rspb.1994.0012. PMID 8153140. http://journals.royalsociety.org/openurl.asp?genre=article&issn=09628452&volume=255&issue=1342&spage=81. 15. ^ Levin SA, Pimentel D (1981). "Selection of intermediate rates of increase in parasite-host systems". American Naturalist 117: 30815. doi:10.1086/283708. 16. ^ Fernanda Pontes (20 March 2008). "Secretrio estadual de Sade Srgio Crtes admite que estado vive epidemia de dengue" (in Portuguese). O Globo Online. http://oglobo.globo.com/rio/mat/2008/03/20/secretario_estadual_de_saude_sergio _cortes_admite_que_estado_vive_epidemia_de_dengue-426368388.asp.. 17. ^ CNN (3 April 2008). "Thousands hit by Brazil outbreak of dengue". CNN. http://www.cnn.com/2008/HEALTH/conditions/04/03/brazil.dengue/index.html.. 18. ^ http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7CPT4KKNNH52&_user=130561&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C0 00010878&_version=1&_urlVersion=0&_userid=130561&md5=4cc1b9743b4fd df5a0567b16b99bc130 19. ^ Marcos Wozniak (12 March 2009).. 20. ^ Sri Lanka [ http://srilankatourismboard.com/news/index.php? option=com_content&view=article&id=45:dengue-outbreak-claims-168lives&catid=1:latest-news] 21. ^ "Pediatric Dengue Vaccine Initiative". 2008. http://www.pdvi.org/. Retrieved 2008-10-05. 22. ^ "Thailand to test Mahidol-developed dengue vaccine prototype". People's Daily Online. 2005-09-05. http://english.people.com.cn/200509/05/eng20050905_206569.html. Retrieved 2006-10-08. 23. ^ Edelman R (July 2007). "Dengue vaccines approach the finish line". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 45 Suppl 1: S5660. doi:10.1086/518148. PMID 17582571. http://www.journals.uchicago.edu/doi/abs/10.1086/518148?url_ver=Z39.882003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov. 24. ^ Vu SN, Nguyen TY, Kay BH, Marten GG, Reid JW (01 October 1998). "Eradication of Aedes aegypti from a village in Vietnam, using copepods and community participation". Am J Trop Med Hyg. 59 (4): 65760. PMID 9790448. http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=9790448.

25. ^ "Water bug aids dengue fever fight". BBC News. 2005-02-11. http://news.bbc.co.uk/1/hi/health/4257935.stm. Retrieved 2008-10-05. Kay B, Vu SN (2005). "New strategy against Aedes aegypti in Vietnam". Lancet 365 (9459): 6137. doi:10.1016/S0140-6736(05)17913-6. PMID 15708107. 26. ^ "Control of aedes vectors of dengue in three provinces of Vietnam by use of Mesocyclops (Copepoda) and community-based methods validated by etomology, clinical, and serological surveillance". The American Society of Tropical Medicine and Hygiene. 2002. http://www.ajtmh.org/cgi/content/abstract/66/1/40. Retrieved 2009-02-18. 27. ^ "Dengue fever GPS mapping". CNN.com Technology. 2007-07-09. http://edition.cnn.com/2007/TECH/07/02/health.innovations. Retrieved 2009-0107. 28. ^ "Health Awards Benefiting Humanity Laureates". Tech Museum of Innovation. 2006. http://www.techawards.org/laureates/stories/index.php?id=126. Retrieved 2009-01-07. 29. ^ McMeniman CJ, Lane RV, Cass BN, et al. (January 2009). "Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti". Science 323 (5910): 1414. doi:10.1126/science.1165326. PMID 19119237. http://www.sciencemag.org/cgi/content/abstract/323/5910/141. 30. ^ "Dengue fever breakthrough". Sydney Morning Herald. 2009-01-02. http://www.smh.com.au/news/specials/science/dengue-feverbreakthrough/2009/01/02/1230681699070.html. Retrieved 2009-01-02. 31. ^ Lai CJ, Monath TP (2003). "Chimeric flaviviruses: novel vaccines against dengue fever, tick-borne encephalitis, and Japanese encephalitis". Advances in virus research 61: 469509. doi:10.1016/S0065-3527(03)61013-4. PMID 14714441. 32. ^ Querec T, Bennouna (2006). "Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity". J. Exp. Med. 203 (2): 41324. doi:10.1084/jem.20051720. PMID 16461338. 33. ^ Filomatori CV, Lodeiro MF, Alvarez DE, Samsa MM, Pietrasanta L, Gamarnik AV (2006). "A 5' RNA element promotes dengue virus RNA synthesis on a circular genome". Genes Dev. 20 (16): 223849. doi:10.1101/gad.1444206. PMID 16882970. 34. ^ Kinney RM, Huang CY, Rose BC, et al. (April 2005). "Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers". Journal of virology 79 (8): 511628. doi:10.1128/JVI.79.8.5116-5128.2005. PMID 15795296. PMC: 1069583. http://jvi.asm.org/cgi/pmidlookup? view=long&pmid=15795296. 35. ^ Burrer R, Neuman BW, Ting JP, et al. (June 2007). "Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models". Journal of virology 81 (11): 563748. doi:10.1128/JVI.02360-06. PMID 17344287. PMC: 1900280. http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=17344287. 36. ^ Stein DA, Huang CY, Silengo S, et al. (September 2008). "Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus". The Journal of antimicrobial chemotherapy 62

(3): 55565. doi:10.1093/jac/dkn221. PMID 18567576. http://jac.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18567576. 37. ^ "Project Summary". Discovering Dengue Drug-Together. University of Texas, Medical Branch. 2007. http://www.utmb.edu/discoveringdenguedrugs %2Dtogether/. Retrieved 2008-10-05. 38. ^ "Dengue fever: essential data". 1999. http://www.cbwinfo.com/Biological/Pathogens/DENV.html#0009. Retrieved 2008-10-05. 39. ^ Harper D (2001). "Etymology: dengue". Online Etymology Dictionary. http://www.etymonline.com/index.php?term=dengue. Retrieved 2008-10-05. 40. ^ a b "etymologia: dengue" (PDF). Emerging Infectious Diseases 12 (6): 893. 2006. http://www.cdc.gov/ncidod/eid/vol12no06/pdfs/etymology.pdf. 41. ^ url=http://www.medterms.com/script/main/art.asp?articlekey=6620 42. ^ Gubler DJ (July 1998). "Dengue and dengue hemorrhagic fever". Clinical microbiology reviews 11 (3): 48096. PMID 9665979. PMC: 88892. http://cmr.asm.org/cgi/pmidlookup?view=long&pmid=9665979. 43. ^ Dengue Fever Fact Sheet. CDC. 44. ^ "Chemical and Biological Weapons: Possession and Programs Past and Present", James Martin Center for Nonproliferation Studies, Middlebury College, April 9, 2002, accessed November 14, 2008. 45. ^ Resch W., L. Zaslavsky, B. Kiryutin, M. Rozanov, Y. Bao, and T. A. Tatusova (April 2009). "Virus variation resources at the National Center for Biotechnology Information: dengue virus". BMC Microbiology 9:65: 65. doi:10.1186/14712180-9-65. http://www.biomedcentral.com/1471-2180/9/65/. 46. ^ "Discovering Dengue Drugs Together". University of Texas Medical Branch. 2009-01-04. http://www.utmb.edu/discoveringdenguedrugs-together/. Retrieved 2009-01-04.

[hide]
vde

Zoonotic viral diseases (A80-B34, 042-079)

Arthropod/ MosquitoBunyaviridaeArbovirus encephalitis: La Crosse encephalitis (Arbovirus) (LCV) California encephalitis (CEV)

Viral hemorrhagic fever: Rift Valley fever (RVFV) Arbovirus encephalitis: Japanese encephalitis (JEV) Australian encephalitis (MVEV, KUNV) St. Louis encephalitis (SLEV) West Nile fever (WNV) Flaviviridae Viral hemorrhagic fever: Dengue fever (DV) other: Yellow fever (YFV) Zika fever Arbovirus encephalitis: Eastern equine encephalomyelitis (EEEV) Western equine encephalomyelitis (WEEV) Venezuelan equine Togaviridae encephalomyelitis (VEEV) other: Chikungunya (CV) O'Nyong-nyong fever (OV) Ross River fever (RRV) Bunyaviridae Viral hemorrhagic fever: Crimean-Congo hemorrhagic fever (CCHFV)

Tick

Arbovirus encephalitis: Tick-borne encephalitis (TBEV) Powassan encephalitis (PV) Deer tick virus encephalitis (DTV) Flaviviridae Viral hemorrhagic fever: Omsk hemorrhagic fever (OHFV) Kyasanur forest disease (KFDV/Alkhurma virus) Reoviridae Colorado tick fever (CTFV)

Mammal

Viral hemorrhagic fever: Lassa fever (LV) Venezuelan hemorrhagic fever (Guanarito virus) Arenaviridae Argentine hemorrhagic fever (Junin virus) Bolivian hemorrhagic fever (Machupo virus) Lujo virus Robovirus Bunyaviridae Puumala virus Andes virus Sin Nombre virus Hantavirus infection (HV) VHF: Ebola hemorrhagic fever Marburg hemorrhagic fever Australian bat lyssavirus Mokola virus Duvenhage virus Menangle Henipavirus Borna disease (Borna disease virus)

Filoviridae Bat Rhabdoviridae Bornaviridae

Multiple RhabdoviridaeRabies (RV) Retrieved from "http://en.wikipedia.org/wiki/Dengue_fever" Categories: Viral diseases | Flaviviruses | Tropical diseases | Hemorrhagic fevers | Insectborne diseases | Biological weapons | Health problems in India | Neglected diseases | Virus-related cutaneous conditions

Dengue Fever
Overview
Dengue fever is an infectious disease carried by mosquitoes and caused by any of four related dengue viruses. This disease used to be called "break-bone" fever because it

sometimes causes severe joint and muscle pain that feels like bones are breaking, hence the name. Health experts have known about dengue fever for more than 200 years. Dengue fever is found mostly during and shortly after the rainy season in tropical and subtropical areas of

Africa Southeast Asia and China India Middle East Caribbean and Central and South America Australia and the South and Central Pacific

An epidemic in Hawaii in 2001 is a reminder that many locations in the United States are susceptible to dengue epidemics because they harbor the particular types of mosquitoes that transmit dengue virus. Worldwide, 50 to 100 million cases of dengue infection occur each year. This includes 100 to 200 cases in the United States, mostly in people who have recently traveled abroad. Many more cases likely go unreported because some health care providers do not recognize the disease. During the last part of the 20th century, many tropical regions of the world saw an increase in dengue cases. Epidemics also occurred more frequently and with more severity. In addition to typical dengue, dengue hemorrhagic fever (DHF) and dengue shock syndrome also have increased in many parts of the world. Globally, there are an estimated several hundred thousand cases of DHF per year.

Dengue Fever
Cause
Dengue fever can be caused by any one of four types of dengue virus: DEN-1, DEN-2, DEN-3, and DEN-4. You can be infected by at least two if not all four types at different times during your lifetime, but only once by the same type.

Dengue Fever
Transmission
You can get dengue virus infections from the bite of an infected Aedes mosquito. Mosquitoes become infected when they bite infected humans, and later transmit infection to other people they bite. Two main species of mosquito, Aedes aegypti and Aedes albopictus, have been responsible for all cases of dengue transmitted in this country. Dengue is not contagious from person to person.

Dengue Fever
Symptoms
Symptoms of typical uncomplicated (classic) dengue usually start with fever within 4 to 7 days after you have been bitten by an infected mosquito and include

High fever, up to 105F Severe headache Retro-orbital (behind the eye) pain Severe joint and muscle pain Nausea and vomiting Rash

The rash may appear over most of your body 3 to 4 days after the fever begins, and then subsides after 1 to 2 days. You may get a second rash a few days later. Symptoms of dengue hemorrhagic fever include all of the symptoms of classic dengue plus

Marked damage to blood and lymph vessels Bleeding from the nose, gums, or under the skin, causing purplish bruises

This form of dengue disease can cause death. Symptoms of dengue shock syndrome--the most severe form of dengue disease--include

all of the symptoms of classic dengue and dengue hemorrhagic fever, plus

Fluids leaking outside of blood vessels Massive bleeding Shock (very low blood pressure)

This form of the disease usually occurs in children (sometimes adults) experiencing their second dengue infection. It is sometimes fatal, especially in children and young adults.

Diagnosis
Your health care provider can diagnose dengue fever by doing two blood tests, 2 to 3 weeks apart. The tests can show whether a sample of your blood contains antibodies to the virus. In epidemics, a health care provider often can diagnose dengue by typical signs and symptoms.

Dengue Fever
Treatment
There is no specific treatment for classic dengue fever, and most people recover within 2 weeks. To help with recovery, health care experts recommend

Getting plenty of bed rest Drinking lots of fluids

Taking medicine to reduce fever

CDC advises people with dengue fever not to take aspirin. Acetaminophen or other overthe-counter pain-reducing medicines are safe for most people. For severe dengue symptoms, including shock and coma, early and aggressive emergency treatment with fluid and electrolyte replacement can be lifesaving.

Dengue Fever
Prevention
The best way to prevent dengue virus infection is to take special precautions to avoid being bitten by mosquitoes. Several dengue vaccines are being developed, but none is likely to be licensed by the Food and Drug Administration in the next few years. When outdoors in an area where dengue fever has been found

Use a mosquito repellent containing DEET, picaridin, or oil of lemon eucalyptus Dress in protective clothinglong-sleeved shirts, long pants, socks, and shoes

Because Aedes mosquitoes usually bite during the day, be sure to take precautions, especially during early morning hours before daybreak and in the late afternoon before dark. Other precautions include

Keeping unscreened windows and doors closed Keeping window and door screens repaired Getting rid of areas where mosquitoes breed, such as standing water in flower pots, containers, birdbaths, discarded tires, etc

Complications
Most people who develop dengue fever recover completely within 2 weeks. Some, especially adults, may be tired and/or depressed for several weeks to months after being infected with the virus. The more clinically severe dengue hemorrhagic fever and dengue shock syndromes can result in vascular (blood vessel) and liver damage, and can be life-threatening.

Dengue Fever
NIAID's Role in Dengue Fever Research
Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID) are trying various approaches to develop vaccines against dengue. Researchers in NIAID laboratories in Bethesda, Maryland, are using weakened and harmless versions of dengue viruses as potential vaccine candidates against dengue and related viruses. Other NIAIDfunded investigators are trying to develop dengue virus vaccines using recombinant proteins (with or without adjuvants), viral vectors, and DNA. Several projects are currently ongoing to identify the host and viral factors that determine the virulence and transmissibility of different dengue virus strains. Other researchers supported by NIAID are investigating ways to treat infected individuals and to prevent dengue viruses from reproducing inside mosquitoes. Although dengue virus has emerged as a growing global threat, scientists know little about how the virus infects cells and causes disease. New research is beginning to shed light on how the virus interacts with humans; for example, how dengue virus damages cells and how the human immune system responds to dengue virus infection. Much of the basic research on dengue fever is done in labs at NIAID. Read more on Dengue Research in NIAID Labs.