CV Professor Peter GHOSH

Abridged CV 03/07 Peter Ghosh
Professor Peter GHOSH Place and date of birth : Nationality & marital status : Present position and contact details : London, United Kingdom. 4th August 1940 Australian, Married CEO and Director of Research, Institute of Nutraceutical Research, PO Box 35, Brookvale, NSW 2100, Australia Telephone: 61-02-99058440 Mobile: 0410246469 Facsimile: 61-02-99058443 E-mail: Biopartners@tpg.com.au
Other Current Appointments 2006 Vice President, Cartilage Regenerative Programs, Mesoblast Ltd, Melbourne, Victoria 3000, Australia. 2003 Board Member, Institute of Bone and Joint Research, Royal North Shore Hospital of Sydney, St Leonards, NSW 2065, Australia. 2003 Honorary Associate Professor, Faculty of Medicine, University of Sydney, Australia. 2003 Honorary Member, Department of Orthopaedics, Royal North Shore Hospital of Sydney, Australia. 2003 Board Member, Bone and Joint Research Foundation of the University of Sydney, Australia. 2005 Chairman, Proteobioactives Pty Ltd, Brookvale, NSW 2100, Australia. 2006 Visiting Professor, Department of Biochemistry, Faculty of Medicine. Chiang Mai University, Thailand. Past Appointments 1998/02 President, Institute of Bone and Joint Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. 1986/02 Associate Professor, Department of Surgery, University of Sydney. 1973/02 Academic Director, Raymond Purves Bone and Joint Research Laboratories, University of Sydney. 1978/79 Visiting Research Fellow, Dept. Pathology, University of British Columbia, Vancouver, British Columbia, Canada. 1969/70 Head of Department of Medicinal Chemistry, Riker Research Institute, Sydney, Australia. 1966/68 Research Fellow, John Curtin School of Medical Research, ANU Canberra, Australia. 1963/66 PhD Studentship, University of East Anglia, Norwich, Norfolk, UK 1962/63 Research Scientist, Koch-Light Laboratories, Haverhill, Suffolk, UK Academic Qualifications 1962 Bachelor of Science, BSc (Honours) (Kings College, University of London, UK) 1966 Doctor of Philosophy, PhD (University of East Anglia, Norwich, UK) 1975 Fellow Royal Australian Chemical Institute, FRACI (Australia) 1989 Fellow Royal Society of Chemistry, FRSC (UK) 1989 Chartered Chemist, CChem (UK)
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Abridged CV 03/07- Peter Ghosh
1995 Doctor of Science, DSc (University of Sydney, Australia) 2004 Chartered Scientist, CSc (UK) Major honorary positions held in scientific societies and other professional organisations 1978/80 Australian Director, International Foundation for Cancer Research (Bethesda, USA) 1976/83 Treasurer, Connective Tissue Society of Australia and New Zealand 1982 Specialist Colloquia Organiser, 12th International Congress of Biochemistry, Perth, WA 1982/95 Scientific advisory committee.Osteogenesis Imperfecta Society of NSW 1983/90 Board Member, SpineCare/Children's Spinal Research Foundation 1983/85 President, Connective Tissue Society of Australia and New Zealand 1984 Co-convenor, Australian Orthopaedic Association Continuing Education Program (Basic Science) 1984/85 Member, Scientific Advisory Committee - International League Against Rheumatism (ILAR) Meeting, Sydney 1984/85 Convenor, International League Against Rheumatism Satellite Meeting, "Recent advances in connective tissue research", Port Stephens 1988 Chairman, Organizing and Program Committee, Pan-Pacific Connective Tissue Societies Meeting, Cairns, Qld 1989 Member, International Working Party on Osteoarthritis, Cincinnati, Ohio, USA 1990 Member, International Working Party on Osteoarthritis, Val-David, Quebec, Canada 1990 Member, Executive Committee - Australasian & New Zealand Orthopaedic Research Society 1991 Founding Member, Osteoarthritis Research Society (Paris, France) 1992/94 President, Australian and New Zealand Orthopaedic Research Society 1993 Member Scientific Committee (Osteoarthritis), International League Against Rheumatism Congress, Barcelona, Spain 1993 Member, International Scientific Advisory Board - Vth Prague Rheumatological Symposium, Czechoslovakia 1993/95 Deputy Director, Science Council, RNSH 1994 Member, Organising Committee - University of Sydney Orthopaedic Silver Jubilee/Australian and New Zealand Orthopaedic Research Society Meeting, Sydney 1994/96 Chairman, Medical Research Council Sub-committee, RNSH 1994/96 Member, Scientific Advisory Committee (Osteoarthritis and Cartilage) and Symposia Executive Committee - Asia Pacific League Against Rheumatism (APLAR) Congress, Melbourne, Vic. 1995/99 Academic Director, Bone and Joint Research Foundation 1995 Chairman, Organising Committee - Matrix Biology Society of Australia and New Zealand/Federation of Asia and Oceania Biochemist and Molecular Biologist Satellite Meeting, Terrigal 1995/02 Co-Chair, Post-graduate student review committee, Dept Surgery 1996 Member, Scientific Advisory Committee, European Society for Osteoarthrology, Ghent, Belgium 1996/97 Co-chairman, Scientific Program Director - Osteoarthritis Research Society / International League Against Rheumatism Conjoint Meeting, Singapore
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1997/02 1997 1997/00 1998 1999 1999/00 2001/02 2001/03 2001/05 2002/03
Board Member, Osteoarthritis Research Society International (OARSI) Board Member, Northern Medical Research Foundation Member, RNSH Medical Research Committee Chairman, Scientific Program Committee, Association Research Circulation Osseous (ARCO), SICOT meeting, Darling Harbour, Sydney Scientific Advisory Committee, Pan-Pacific Connective Tissue Societies Meeting, Queenstown, NZ Member, Scientific Program Committee, Cartilage Products Technology, Banff, Canada Chair, Scientific Program committee OARSI International OA Congress, Sydney, Member, Australian National Action Network Committee, Bone and Joint Decade Member Stryker Biotech, scientific advisory committee, Sydney Member, Lincoln Foundation Scientific Advisory Committee, Sydney
Prizes and Awards Smith and Nephew, Australian Spinal Research Prize (1997) (with Melrose J and Taylor TKF). European Spinal Research Society Award for best paper 2002-3 (with Shen B, Taylor TKF and Melrose J). Elected Life Member, International Society for Hyaluronan Sciences (USA) (2004) Charles R Ream Award for research excellence (Current Therapeutic Research Publication) (2005) (with Edelman J, March L and Smith M). Editorial Boards/Journal Reviewer (1985 present) Current Rheumatology Reviews (Editorial Board) Osteoarthritis and Cartilage (Editorial Board) APLAR Journal of Rheumatology (Editorial Board) Arthritis and Rheumatism (Reviewer) Annals of Rheumatic Diseases (Reviewer) Journal of Orthopaedic Research (Reviewer) Journal of Rheumatology (Reviewer) Spine (Reviewer) Seminars in Arthritis and Rheumatism (Reviewer) Scientific Assessor Major Grants (1980 2002): National Health & Medical Research Council Health Research Council of New Zealand (committee) Health Research Council of Hong Kong Arthritis Foundation of Canada ARGC, ARA, AOA, ARA (Australia) Wellcome Foundation (UK) US-Israel Binational Science Foundation (USA) Invitations to present lectures or chair national or international scientific meetings / congresses: 1974 - 1980 1. "Articular Cartilage" Symposium. Organised by the Institute of Postgraduate Studies, University of London, UK, 1974 (Invited Speaker and Participant).
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South East Asia and Pacific Area League (SEAPAL), 3rd Rheumatology Symposium. Canberra, ACT, 1977 (Invited Speaker). Symposium: "The Aetiopathogenesis of Osteoarthrosis". (Arthritis and Rheumatism Council, UK), Cardiff, UK, 1977 (Invited Speaker) 11th Congress of International Association of Gerontology - Satellite Meeting "Ageing in Australia". Sydney, NSW, 1978 (Invited Speaker). Osteoarthrosis Workshop (Institute of Postgraduate Studies), University of London, UK, 1979 (Invited Speaker and Participant).
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1980 - 1985 6. SEAPAL, 4th Rheumatology Congress. Manila, Philippines, 1980 (Invited Speaker).
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International Symposium: "Osteoarthritis and Inflammation". Organised by the University of Miami, School of Medicine, Palm Aire, Florida, USA, 1981 (Invited Speaker and Participant). International Union of Biochemistry Congress - Workshops on "Matrix Biology". Perth, WA, 1982 (Chairman and Invited Speaker). International Union of Biochemistry Congress - Satellite Meeting: "Connective tissue in health and disease". Monash University, Vic, 1982 (Invited Chairman and Speaker). Western Pacific Connective Tissue Societies Meeting. St. George, Utah, USA, 1983 (Invited Speaker). SEAPAL, 5th Rheumatology Congress. Bangkok, Thailand, 1984 (Invited Speaker). Pan-Pacific 17th Surgical Congress. Sydney, NSW, 1984 (Invited Speaker). Inaugural Gordon Research Conference on "Proteoglycans". Plymouth, New Hampshire, USA, 11-15 June 1984 (Invited Participant). XVI International Congress in Rheumatology (ILAR). Sydney, NSW, 1985. (Chairman of two Sessions, one Workshop and Review Speaker in two Sessions) (Member of the Scientific Advisory Board). International Symposium: "Recent Advances in Connective Tissue Research". International League Against Rheumatism Satellite Meeting, Port Stephens, NSW, May 1985. (Chairman and Speaker). NH & MRC Special Workshop: "Ageing Research in Australia". University of New South Wales, NSW, August 1985 (Invited Speaker and Discussant).
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1986 - 1990 17. International Symposium: "Proteases and Their Involvement in the Pathogenesis of Osteoarthritis". Val David, Quebec, Canada, August 1986 (Invited Speaker).
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Prince Henry's Hospital, Melbourne, Victoria. Symposium: "The Challenge of Osteoarthritis". (Sponsored by Ciba-Geigy), August 1986 (Invited Review Lecturer). New Zealand Rheumatism Association Symposium: "Cartilage Science in Arthritis". Auckland, NZ, March 1987 (Invited Speaker). Special Lecture Tour of New Zealand (Auckland, Hamilton, Christchurch, Dunedin): "The Etiopathogenesis of OA and a Rational Approach to its Treatment". Sponsored by Roussel (NZ), July 1987. Inaugural Postgraduate Medical Research Symposia: "Recent Advances in Orthopaedic Research". Department of Orthopaedics, National University of Singapore, 12-23 July 1987 (Visiting Professor and Lecturer). Symposium: "The Aetiopathogenesis of Osteoarthritis". The Institute of Orthopaedics, University of London, UK, September 1987 (Invited Participant and Speaker). Symposium: "The Lumbar Disc". Combined Meeting - Australian Spinal Research Society and Australian Association of Musculoskeletal Medicine. Brisbane, Qld, October 1987 (Invited Speaker). German Drug Regulatory Authority (Bundesgesund heits - amt. BGA). European Inquiry into "Chondroprotective Drugs". Berlin, Germany, 9 May 1988 (Invited Expert Witness). Annual Meeting of the Japanese Orthopaedic Association. Tokyo, Japan, September 1988 (Invited Guest Lecturer and Participant). Sociedade Brasileira de Reumatogia XVII Congress. Florianopolis, Brazil, 25-29 September 1988 (Invited Guest Lecturer - two lectures). SEAPAL Symposium: "Therapeutic (NSAIDs) Modulation of Cartilage Catabolism in Arthritis". Tokyo, Japan, 9 September 1988 (Chairman and Speaker). "Recent Advances in Cartilage Research". Inaugural Geigy Rheumatology Symposium. Melbourne, Vic, November 1988 (Invited Speaker). American College of Rheumatology Satellite Meeting: "Cartilage Degradation, is there a Place for Chondroprotective Agents?" Cincinnati, USA, 17 June 1989 (Chairman and Speaker). Geigy Rheumatology Symposium "Osteoarthritis". Surfers Paradise, Qld, 22-22 October 1989 (Chairman - Round-table Discussant). Inaugural Pan-Pacific Connective Tissue Societies Symposium. Cairns, Qld, 5-10 November 1989 (Chairman, Speaker and Chairman of Program). Japanese Connective Tissue Annual Society Meeting: "Role of Mechanical Factors in the Metabolism of Cartilage". Tokyo, Japan, 21-23 February 1990 (Invited Lecturer).
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Symposium: "Synovium-cartilage Inter-relationships, Physiology and Pathology in Osteoarthritis". 9th Centenary Foundation Meeting of the University of Bologna. Bologna, Italy, 21-24 May 1990 (Invited Speaker - two lectures). Inaugural Combined Meeting of the Sydney Carbohydrate and Protein Groups. University of New South Wales, NSW, July 1990 (Review Lecturer). Combined Meeting of the New Zealand Rheumatism and Australian Rheumatism Association Meeting. Queenstown, NZ, September 1990 (Invited Chairman). First International Symposium and Workshop on the "Synovium". University of Pennsylvania, Philadelphia, PA, USA, September 1990 (Invited Speaker). Osteoarthritis Symposium: "Diagnosis and Therapy". La Sapinire, Val-David, Quebec, Canada, 3-5 October 1990 (Invited Speaker).
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1991 - 1995 38. Fidia Research Symposium: "Laboratory Evaluation and Development of Chondroprotective Agents". Albano Terme, Italy, 25 June 1991 (Invited Lecturer and Workshop Chairman).
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European League Against Rheumatology (EULAR) Osteoarthritis Symposium. Budapest, Hungary, 30 June - 7 July 1991 (Invited Speaker). Inaugural Meeting of the Orthopaedic Research Society of Australia and New Zealand. Christchurch, NZ, 18 August 1991 (Speaker and Chairman). 11th Congress of the Asian Orthopaedic Association. Kuala Lumpur, Malaysia, 21-23 November 1991 (Invited Speaker and Chairman). Ciba-Geigy Cartilage Symposium in conjunction with Australian Rheumatology Association Meeting. Perth, WA, 1-4 December 1991 (Co-chairman and Speaker). Australian Society for Medical Research National Meeting, Canberra, ACT, 17 December 1991 (Invited Speaker). 10th Congress of the Italian Arthroscopy Society Symposium: "Focus on Arthroscopic Approach to the Diagnosis and Follow-up of Osteoarthritis of the Knee". 19-22 January 1992. Cortina d'Ampezzo, Italy (Invited Speaker and Workshop Participant). 19th Congress of the European Society of Osteology (ESOA). Noordwijkerhout, Netherlands, May 1992 (Plenary Lecturer). The Spinal Society of Australia Meeting. Adelaide, SA, August 1992 (Invited Speaker). 7th Asia Pacific League Against Rheumatology (APLAR) Congress. Bali, Indonesia, 13-18 September 1992 (Invited Congress Lecturer). 1st Congress of the Osteoarthritis Research Society: "The Regulation of Cartilage Metabolism in OA". 10-12 December 1992, Paris, France (Speaker and Chairman of Session 3) (Invited to become Member of Editorial Board).
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Workshop: "Pathology and Physiology of Osteoarthritis" Symposium. University of Cologn, Germany, 13-14 December 1992 (Invited Speaker) (2 papers). Special Invited Lecture: "New Horizons in Osteoarthritis Research". University of Padua, Italy, December 1992 (Visiting Professor). 39th Meeting of the Orthopaedic Research Society (USA). February 1993 (Chairman of Cytokines Session). International League Against Rheumatism (ILAR) XVIII Congress, Barcelona, Spain, July 1993 (Invited Scientific Adviser also) Congress Symposium - Session - "Osteoarthritis, Sulphated and Non-sulphated Drug Therapy" (Review Speaker). Symposium - Osteoarthritis: "New Perspective in Disease Modification" (Invited Speaker). Workshop - Osteoarthritis: "New Understandings" (Invited Speaker and Discussant). Vth Prague Rheumatology Symposium, Czechoslovakia. September 1993 (Plenary Lecture and Member of Scientific Advisory Committee - Disease Modification in Osteoarthritis). 2nd Pan-Pacific Connective Tissue Societies Symposium. September 1993, Bali, Indonesia, (Invited Lecture: "Pathobiology of Osteoarthritis" and Chairman of Session). Royal Swedish Academy of Science. Invited member of Australian delegation to visit Swedish universities and present lectures. Speaker at a Special Symposium on "Matrix Biology". 23-27 September 1993, Medevi Brunn, Sweden. Australian Orthopaedic Association Annual Meeting and Australia New Zealand Orthopaedic Research Society combined plenary session. (Chairman and Review Lecture: session 4 - "The Role of Mechanical Factors on the Metabolism of Disc Proteoglycans"). Adelaide, SA, 30 September 1993. Japanese Rheumatism Foundation. 3rd International Symposium on the "Treatment of Osteoarthritis with Slow Acting Anti-rheumatic Drugs". Tokyo, Japan, 5 March 1994 (Invited Lecturer). Spinal Research Society of Australia - Smith and Nephew Research Prize Award (in conjunction with Professor TKF Taylor and Dr. J Melrose). RACS, Melbourne, Vic, 1994. XVI International Congress of Biochemistry, Satellite Symposium on "Collagen". Madras, India, 15-17 September 1994 (Invited Chairman and Speaker). International Symposium: "Osteoarthritis: Challenges for the 21st Century". La Sapinire, Quebec, Canada, 5-7 October 1994 (Invited Speaker). Connective Tissue Society of Australia and New Zealand. Warburton, Vic, December 1994 (Chairman).
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International Expert Workshop on "Hyaluronic Acid" (Bayer AG, sponsor). Rathaus Schnenberg, John F. Kennedy Platz, Berlin, Germany, 27-29 January 1995 (Invited Speaker and Workshop Participant). Visiting Professor and Lecturer: "The Role of Mechanical Factors and TGF-b on Cartilage Metabolism". University of Caen, Normandy, France, 31 January 1995. Symposium: "Inflammation and the Extracellular Matrix". Sponsored by the Rebecca L. Cooper Medical Research Foundation. Sydney, NSW, 11-12 May 1995 (Invited Speaker). Combined New Zealand and Australian Rheumatology Association Meeting. Auckland, NZ, 14-17 May 1995 (Invited Speaker). XII European Congress of Rheumatology. Amsterdam, Netherlands, 18-23 June 1995 (Invited Speaker). Australian Association of Musculoskeletal Medicine Annual Conference. Canberra, ACT, 22-23 July 1995 (Invited Speaker). Australian and New Zealand Orthopaedic Association Annual Meeting. Melbourne, Vic, September 1995 (Chairman). 7th International Seminar on "The Treatment of Rheumatic Diseases". Tel-Aviv, Israel, 1-16 December 1995 (Invited Speaker).
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1996 73. 9th Annual Meeting Japanese Society of Cartilage Metabolism. Nagoya University, Japan, 29 February - 2 March 1996. Invited Speaker: (a) Symposium: Novel concepts of osteoarthritis (29.2.96) (b) Professor Shinmei Memorial Lecture (2.3.96)
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8th Asia Pacific League Against Rheumatism Congress of Rheumatology. Melbourne, Vic, 21-26 April 1996. Invited Speaker and/or chairman: (a) "Cartilage Structure and Function in Osteoarthritis" (23.4.96) (b) Seikagaku Symposium: "Hyaluronan and the Biochemical Lesions of Osteoarthritis" (23.4.96) (c) Arthropharm Symposium: "Sites and Modes of Action of Polysulphate Polysaccharides in Osteoarthritis" (24.4.96) (d) Continuing Orthopaedic Education Workshop: "Physiological Treatments of Arthritis" (26.4.96)
Annual Scientific Meeting Royal Australasian College of Physicians. Canberra, ACT, 7-10 May 1996. Invited Lecture: "Disc Metabolism".
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Workshop: "Osteoarthritis Clinical Trials". (Combined meeting of OARS Taskforce, GREES, OMERACT III). Washington, DC, USA, 25-27 May 1996 (Invited Workshop Participant). 21st Symposium of the European Society for Osteoarthrology. Ghent, Belgium, 25-28 September 1996 (Invited Lecturer and Member of Scientific Advisory Committee). Australian Society for Experimental Pathology Annual Scientific Meeting. University of New South Wales, NSW, 7-11 October 1996 (Invited Lecture - The Boehringer Lecture). 3rd Pan-Pacific Connective Tissue Societies Symposium. Kamuela, Hawaii, USA, 20 November - 5 December 1996 (Chairman - Session: ECM of Bone and Cartilage). 7th International Symposium on "Bone Necrosis". Fukuoka, Japan, 3-5 October 1996 (Invited Participant / Speaker). ASEAN / Indonesian Orthopaedic Association Meeting, Bali, Indonesia, 11-13 November 1996 (Plenary Lecturer).
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1997 81. Combined Osteoarthritis Society and International League Against Rheumatism (ILAR) Congress, Singapore, June 1997 (Chairman and Invited Speaker) (Cochair Scientific Program and Organising Committee).
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New Zealand Musculoskeletal Research Society Annual Meeting, Auckland, New Zealand, August 1997 (Invited Speaker). Japanese Arthritis Society Annual Meeting, Nagota, Japan, 17-18 October 1997 (Invited Speaker).
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1998 84. Combined Meeting of the 5th Rheumatism Association of ASEAN (RAA) and 3rd Asia-Pacific League of Associations for Rheumatology (APLAR) Congress, Manila, Philippines, 18-22 January 1998 (Invited Plenary Lecturer, Symposium Lecturer and Chairman).
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5th International Congress Research and Therapeutics in Osteoarthritis: Interleukin-1 Inhibitors. La Napoule, France, 31 January - 1 February 1998 (Invited Speaker). Australian Rheumatology Association Scientific Meeting, Sydney, NSW, May 1998 (Symposium Lecturer - Osteoarthritis, Pathogenesis and Treatment). AVS Satellite Meeting on NSAIDs and OA. Darling Harbour, 19 May 1998. (Two Lectures on OA and NSAID treatment). UCB Conference on Osteoarthritis. New York, USA, 23 May 1998. (Lecture Animal Models of OA). New Frontiers in Joint Arthroplasty St. George Hospital, Kogarah, NSW, 21 August 1998. Lecture Cartilage Metabolism in OA.
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13th Annual Japanese Orthopaedic Research Society (JORS) Meeting, Nagoya, 25-27 September 1998. Two lectures: (a) Pathogenesis of Disc Degeneration and Future Therapies. (b) Biomechanical and Ultrastructure Changes in Cartilage in Early Traumatic Arthritis. (Invited Speaker). Osteoarthritis Research Society, Role of Nitric Oxide and Cycloxygenase in Osteoarthritis, Florence, Italy, 15-16 October 1998 (Chairman of Session 3)
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1999 92. Socit Internationale de Chirurgie Orthopdique et de Traumatologie (SICOT), 21st World Congress, Sydney, Australia, 18-23 April 1999 (Invited Symposium Speaker - Pathogenesis and Treatment of Osteoarthritis).
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4th World Congress on Osteoarthritis and Satellite Symposia - OsteoArthritis Research Society International, Vienna, Austria, 16-19 September 1999 (Invited Speaker and Chairman). 4th Pan-Pacific Connective Tissue Society Meeting, Queenstown, NZ, November 1999 (Invited Speaker and Chairman).
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2000 95. SA Australian Rheumatology Association (Meeting), Adelaide, SA, Australia, 23 February 2000 (Invited Speaker).
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The First International Symposium on Antler Science and Product Technology, Banff, Alberta, Canada, 9-12 April 2000 (Invited Speaker and Chairman). 9th APLAR Congress and 6th Chinese Rheumatology Association, Beijing, China, 21-26 May 2000 (Invited Speaker and Chairman).
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2001 98. Invited Workshop Participant: "The Role of Bone in Osteoarthritis". Procter and Gamble Symposium, Coral Gables, Miami, Florida, USA, 9-11 February 2001.
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Australian Society for Cellular and Molecular Gerontology, "Osteoarthritis, Genetic and Molecular Mechanisms". Melbourne, Vic, 19-22 March 2001 (Guest Speaker). Symposium EULAR 2001 Meeting, "Mechanism of Action of Hyaluronan in Osteoarthritis". Prague, Czech Republic, 13-16 June 2001 (Review Lecture). 6th World Congress on Osteoarthritis and Satellite Symposia - OsteoArthritis Research Society International, Washington, DC, USA, 30 September-3 October 2001 (Invited Chairman). Ghosh P: The challenges associated with the biologic repair of cartilage defects. Institute of Bone and Joint Research Symposium, Sydney University, NSW, 24 November 2001.
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2002 103. McCraig Osteoarthritis Workshop, Emerald Lake, Alberta, Canada, 22-23 March 2002. (Invited Workshop Participant).
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OARSI Annual Congress, Sydney, NSW, 22-25 September 2002. (Chairman "Symposium 2: Integrative Medicine, A Maturing Science") Asia Pacific Forum on New Therapeis in Rheumatic Disease, Singapore, 9-13 October 2002. (Plenary Speaker and Symposium Participant). Hong Kong Medical Association Meeting, Etiopathogenesis of Osteoarthritis and New Strategies for its Treatment. Hong Kong, 26 October 2002. (Invited Speaker). Congress, Hyaluronan Satellite Meeting, Bangkok, Thailand, 1-6 December 2002. (Invited Speaker)
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2003 108. Hyaluronan 2003 International Conference, Cleveland, Ohio, USA, October 2003. (Invited Session Chairman and speaker). 2004 International Cartilage Repair Society Congress, Ghent, Belgium, May, 2004, (Invited Plenary Lecturer). Stryker Australia, Orthopaedic Symposium, Queenstown, New Zealand, July 2004 (Invited basic science Lecturer). 2005 Italian Rheumatology Association, 5th Annual Rheumatics Course: Cartilage and Bone Inter-relationships. Plenary Lecture, Physiology and Pathology in Osteoarthritis and Osteoporosis, Bologna, Italy, June 15-18, 2005 (invited speaker). Japanese Rheumatology Association Congress, Nagasaki, Japan, April 21 25th , 2006 (invited speaker). Publications (i)
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Editor Books / Monographs Ghosh P (Guest Editor): Symposium: Recent advances in connective tissue research. Agents Actions Special 18 (Suppl.): 1986. Ghosh P (Editor): Biology of the intervertebral disc. CRC Press, Uniscience Publication, Boca Raton, Fl, USA, (Vols. I and II) 1988. Moskowitz R, Pavelka K, Ghosh P and Jubb RW: Intra-articular hyaluronans: A new direction in osteoarthritis therapy. A continuing Medical Education Program, Monograph, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA, 2002.
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(ii)
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Chapters in Books Boulton AJ and Ghosh P: Benzofuroxans in advances in heterocyclic chemistry. Academic Press, 10: 8-25, 1969. Taylor TKF, Ghosh P, Bushell GR and Sutherland JM: Disc metabolism in scoliosis. Proc. 5th Symposium on: Scoliosis. The Cardiothoracic Institute, Brompton Hospital, London, 21-22 September 1976. Ed. PA Zorab. Academic Press, London, New York and San Francisco, pp 231-246, 1977. Ghosh P and Taylor TKF: Is primary osteoarthrosis the consequence of ageing? Proceedings of the Satellite Conference of the 11th Congress of the International Association of Gerontology, pp 110-112, Sydney, Australia, 1978. Taylor TKF and Ghosh P: Ageing and the intervertebral disc. Proc. Satellite Conference of the 11th Congress of the International Association of Gerontology, pp 113-115, 1978. Taylor TKF, Ghosh P, Bushell GR and Andrews JL: Glycosaminoglycans and collagen in idiopathic scoliosis. 6th Symposium on: Scoliosis. Ed. PA Zorab, Academic Press, pp 179-193, 1980. Ghosh P and Taylor TKF: The musculoskeletal system. In: Clinical science for surgeons. Ed. W Burnett. Butterworths Press, London, UK, pp 449-478, March 1981. Taylor TKF, Ghosh P, Bushell GR and Stephens RW: Scientific basis for the treatment of intervertebral disc disorders. In: Scientific Foundation of Orthopaedic Surgery and Traumatology. Ed. R Owen, Heinemann Med. Books, UK, pp 387-405, 1981. Ghosh P, Ternai B and Whitehouse B: Benzofurazans and benzofuroxans: Biochemical and Pharmacological Properties. Medicinal Research Reviews 1(2): 159-187, 1981. Burkhardt D and Ghosh P: Synergistic combinations of hyperthermia and inhibitors of nucleic acids and protein synthesis. In: Hyperthermia and cancer treatment. Eds. LJ Anghileri and J Robert, Chapter 7, CRC Press, Inc. USA, 1(2): 127-157, 1984. Ghosh P: Influence of Drugs and Hormones on disc metabolism and the sequelae of its degeneration. In: Biology of the Intervertebral Disc. Ed. P Ghosh, Uniscience Series, Chapter 12, CRC Press, Inc, Boca Raton, Fl, USA, pp 121-159, 1988. Melrose J and Ghosh P: Disc non-collagenous proteins including enzymes and their inhibitors. In: Biology of the Intervertebral Disc. Ed. P Ghosh, Uniscience Series, Chapter 8, CRC Press, Inc, Boca Raton, Fl, USA, pp 189-237, 1988. Ghosh P: Anti-rheumatic drugs and cartilage. In: Bailliere's Clinical Rheumatology, International Practice and Research. Ed. P Brooks, Tindall, Saunders, London, UK, pp 309-338, 1988. Brooks P and Ghosh P: Chondroprotection, myth or reality. In: Controversies in Rheumatology. Ed. N Bellamy, Bailliere Tindall, London, UK, (Vol. 4), pp 293303, 1990.
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Ghosh P, Smith M and Wells C: Second line agents in osteoarthritis. In: Second Line Agents in the Treatment of Rheumatic Diseases. Eds. D Furst and J Dixon. Chapter 15, Marcel Dekker, Inc, NY, pp 363-427, 1991. Ghosh P: Future treatments of osteoarthritis. In: APLAR Rheumatology. Eds. Nasution AR, Darmawan J, Isbagio H. Churchill Livingstone NY, pp 255-258, 1992. Ghosh P, Numata Y, Smith S, Read R, Armstrong S, Johnson K: The metabolic response of articular cartilage to abnormal mechanical loading induced by medial or lateral meniscectomy. Joint Destruction in Arthritis & Osteoarthritis. AAS 39: 89-93, 1993. Ghosh P, Armstrong S, Read R, Numata Y, Smith S, McNair P and Marshall R: Animal models of early osteoarthritis: Their use for the evaluation of potential chondroprotective agents. Joint Destruction in Arthritis & Osteoarthritis. AAS 39: 195-206, 1993. Little C and Ghosh P: Potential use of pentosan polysulphate for the treatment of equine joint disease. In: Joint Disease in the Horse. Eds. CW McIlwraith and GW Trotter, Chapter 17. WB Saunders, 1996. Ghosh P: Role of biomechanical factors. In: Experimental and Clinical Aspects of Osteoarthritis. Eds. Reginster, Henrotin and Martel-Pelletier, Chapter 4.2, Springer-Verlag, Heidelberg, Germany, 1998. Ghosh P, Roubin R and Smith MM: Rationale for the use of antler cartilage products and genes obtained from their cells to treat arthritis and repair cartilage defects following joint injury. In: Antler Science and Product Technology. Eds. Sim JS, Smith MM and Ghosh P: Experimental models of osteoarthritis. In: Osteoarthritis. Diagnosis and Medical/Surgical Management (3rd Edition). Eds. Moskowitz RW, Howell DS, Altman RD, Buckwalter JA and Goldberg VM. Chapter 8, WB Saunders Company, Philadelphia, London, New York, St. Louis, Sydney, Toronto, pp 171-199, 2001. Sunwoo HH, Hudson RJ and Jeon BT. Antler Science and Product Technology Research Centre, University of Alberta, Edmonton, Canada. pp 296-313, 2001.
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Roubin R and Ghosh P: Deer antler cartilage cells express specific growth factors which up-regulate chondrocyte DNA and proteoglycan biosynthesis in vitro. In: Antler Science and Product Technology. Eds. Sim JS, Sunwoo HH, Hudson RJ and Jeon BT. Antler Science and Product Technology Research Centre, University of Alberta, Edmonton, Canada. pp 151-170, 2001. Ghosh P and Cheras P: Vascular mechanism in osteoarthritis. I n : Pharmacopathogenesis. Eds. Breedveld F and Brooks P. Bailliere's-Clinical Rheumatology - Best Practice and Research Clinical Rheumatology, 15(5): 693-709, 2001. Ghosh P: Prospects for pharmacological modification of joint breakdown in osteoarthritis: The biological perspectives. In: Osteoarthritis. (2nd Editions) Eds. Brandt K, Doherty M and Lohmander S. Oxford University Press, Chapter 11.2.1. 4 April 2003. Ghosh P, Smith M, Burkhardt D, Kepic B, Swain M, Cake M, Read R Preclinical studies on the pharmacology of Hyaluronan in relation to its application as an intra-articular therapy for the treatment of osteoarthritis. in Hyaluronan : structure, metabolism, biological activities, therapeutic applications. Balazs EA and Hascall VC, Eds. Matrix Biology Institute Publications, New Jersey, USA, Volume 2: 491 502, 2005. Ghosh P: Systemic Chondroprotection, 5th International Cartilage Repair Society, Ghent Meeting May 26-29, 2004. Medimond International Proceedings Publications.
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Short Articles, Communications in Refereed Journals Taylor, TKF, Bushell GR and Ghosh P: School screening for scoliosis: A Pandora's box. Aust. N.Z. J. Surg. 48(1): 2-3, 1978. Taylor TKF, Bushell GR and Ghosh P: School screening for scoliosis: A look inside Pandora's box. Aust. N.Z. J. Surg. 48(4): 441-443, 1978. Taylor TKF and Ghosh P: Tropical fruit in the treatment of lumbar disc prolapse - A topical issue. Med. J. Aust. Editorial, 142(8): 462-464, 1985. Taylor TKF and Ghosh P: Chemonucleolysis - Unexpected new horizons for research. Aust. N.Z. J. Surg. Editorial, 55: 88-90, 1985. Ghosh P: Chondroprotective drugs and osteoarthritis. (Letter) Ann. Rheum. Dis. 49(5): 338-339, 1990. Taylor TKF, Ghosh P and Melrose J: Chemonucleolysis - A further look at a contentious issue. Med. J. Aust. 153(10): 575-578, 1990. Ghosh P, Holbert C, Read R, Armstrong S and Wilson D: Chondroprotection and NSAIDs. (Letter). Lancet 337(8757): 1612-1613, 1991. Ghosh P and Brooks P: Chondroprotection - Exploring the concept (Editorial). J. Rheumatol. 18(2): 161-166, 1991. Ghosh P: Rheumatology of hyaluronan preparation - NRD 101 (A view point). Clinical Immunotherapeutics. (6)2: 169-170, 1996.
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Ghosh P: Point-of-View Biomechanical effects of chondroitinase-ABC and chymopapain on spinal motion segment. Spine 22(16): 1834-1835, 1997. Ghosh P: Point-of-View Matrix metalloproteinases: The clue to intervertebral disc degeneration? Spine 23(14): 1626, 1998. Ghosh P: A review of the use of Adequan, Cartrophen and pentosan equine in the horse. Aust. Equine Vet. 18(1): 109-110, 2000. Ghosh P and Smith M: Synovial ablation in a rabbit rheumatoid arthritis model using photodynamic therapy. Editorial. ANZ J. Surg. 72(7): 461, 2002. Full-length Articles in Refereed Journals Boulton AJ, Ghosh P and Katritzky AR: Eine allgemaine umlagerung von Hererocyclic und neue Synthesen des Benzotriazol-, Benzofurazan, und Anthranil-Systems. Ang. Chem. 816-817, 1964. Boulton AJ, Ghosh P and Katritzky AR: N-oxides and related compounds. Part XXVIII. 5-Amino and 5-hydroxy benzofuroxans. J. Chem. Soc. (C): 971976, 1966. Boulton AJ, Ghosh P and Katritzky AR: Heterocyclic rearrangements. Part V. Rearrangement of 4-arylazo and 4-nitro-benzofuroxans: New syntheses of the benzotriazole and benzofurazan ring systems. J. Chem. Soc. (B): 1004-1011, 1966. Boulton AJ, Ghosh P and Katritzky AR: Heterocyclic rearrangements. Part VI. Rearrangement of 4-acyl and 4-amino-alkyl benzofuroxans: New synthesis of the anthranil and indazole ring system. J. Chem. Soc. (B): 1011-1015, 1966. Boulton AJ, Ghosh P and Katritzky AR: A new benxofurazan synthesis. Tetrahedron Lett. No. 25: 2887-2888, 1966. Ghosh P: Preparation and study of some 5-, and 7-substituted-4nitrobenzofurazans and their N-oxides: A retro-Boulton-Katritzky rearrangement. J. Chem. Soc. (B): 334-342, 1968. Ghosh PB and Whitehouse MW: Potential antileukemic and immunosuppressive drugs. Preparation and in vitro pharmacological activity of some benzo-2,1,3-oxadiazoles (benzofurazans) and their N-oxides (benzofuroxans). J. Med. Chem. 11: 305-311, 1968. Ghosh PB and Whitehouse MW: 4-Nitrobenzofurazans and 4nitrobenzofuroxans: A new class of thiol neutralising agents and potent inhibitors of nucleic acid synthesis in leucocytes. Biochem. Pharmacol. 17: 158-161, 1968. Ghosh P and Whitehouse MW: 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole: A new fluoroigenic reagent for amino acids and other amines. Biochem. J. 108: 155-156, 1968. Brown DJ and Ghosh PB: The spectra, ionization, and deuteriation of oxazoles and related compounds. J. Chem. Soc. B: 270-276, 1969. Ghosh P and Whitehouse MW: Potential antileukemic and immunosuppressive drugs. II: Further studies with benzo-2,1,3-oxidiazoles
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(benzofurazans) and their N-oxides (benzofuroxans). J. Med. Chem. 12: 505507, 1969.
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Ghosh P: Oxadiazolobenzoxadiazole and thiadiazolobenzoxadiazole - Novel heterocyclic system. Tetrahedron Lett. No. 32: 2999-3000, 1971. Ghosh PB, Ternai B and Whitehouse MW: Potential antileukemic and immunosuppressive drugs. 3. Effects of homocyclic ring substitution on the in vitro drug activity of 4-nitrobenzo-2,1,3-oxadiazoles (4-nitrobenzofurazans) and their N-oxides (4-nitrobenzofuroxans). J. Med. Chem. 15: 255-260, 1972. Ghosh PB and Ternai B: The reaction of 4- and 5-acetyloxazoles with malononitrile. J. Org. Chem. 37(7): 1047-1049, 1972. Bolt AG, Ghosh PB and Sleigh MJ: Benzo-2,1,5-oxadiazoles - A novel class of heterocyclic monoamine oxidase inhibitors. Biochem. Pharmacol. 23: 19631968, 1974. Ghosh PB and Everitt BJ: Furazanobenzofuroxan, furazanobenzothiadiazole, and their N-oxides. A new class of vasodilator drugs. J. Med. Chem. 17: 203206, 1974. Ingman AM, Ghosh P and Taylor TKF: Variation of collagenous and noncollagenous proteins of human knee joint menisci with age and degeneration. Gerontologia 20(4): 212-223, 1974. Braund KG, Ghosh P, Taylor TKF and Larsen LH: Morphological studies of the canine intervertebral disc. The assignment of the beagle to the achondroplastic classification. Res. Vet. Sci. 19(2): 167-172, 1975. Ghosh P, Ingman AM and Taylor TKF: Variations in collagen, noncollagenous proteins, and hexosamine in menisci derived from osteoarthritic and rheumatoid arthritic knee joints. J. Rheumatol. 2(1): 100-107, 1975. Ghosh P, Stephens RW and Taylor TKF: Mechanism of cartilage and synovial fluid hyaluronate degradation by polysaccharidases. Ann. Rheum. Dis. Suppl. 2: 73-74, 1975. Ghosh P, Taylor TKF and Horsburgh BA: The composition and protein metabolism in the immature rabbit intervertebral disc. Cell Tissue Res. 163(2): 223-238, 1975. Ghosh P, Taylor TKF, Yarroll JM, Braund KG and Larsen LH: Genetic factors in the maturation of the canine intervertebral disc. Res. Vet. Sci. 19: 304-311, 1975. Stephens RW, Ghosh P and Taylor TKF: The characterisation and function of the polysaccharidases of human synovial fluid in rheumatoid and osteoarthritis. Biochim. Biophys. Acta 399(1): 101-112, 1975. Stephens RW, Ghosh P, Taylor TKF, Gale CA, Swann JC, Robinson RG and Webb J: The origins and relative distribution of polysaccharidases in rheumatoid and osteoarthritic fluids. J. Rheumatol. 2(4): 393-400, 1975. Braund KG, Ghosh P, Taylor TKF and Larsen LH: The identification and quantitation of connective tissue hexosamines using a combination of gasliquid chromatographic and colorimetric procedures. Anal. Biochem. 64(1): 10-17, 1975.
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Ghosh P, Stephens RW and Taylor TKF: (Letter): The inhibition of synovial fluid polysaccharidases by gold sodium thiomalate. Med. J. Aust. 1: 317, 1975. Braund KG, Ghosh P, Taylor TKF and Larsen LH: The qualitative assessment of glycosaminoglycans in the canine intervertebral disc using a critical electrolyte concentration staining technique. Res. Vet. Sci. 21: 314-317, 1976. Ghosh P, Taylor TKF, Braund KG and Larsen LH: The collagenous and noncollagenous protein of the canine intervertebral disc and their variation with age, spinal level and breed. Gerontology 22(3): 124-134, 1976. Ghosh P, Taylor TKF, Braund KG and Larsen LH: A comparative chemical and histochemical study of the chondrodystrophoid and nonchondrodystrophoid canine intervertebral disc. Vet. Pathol. 13(6): 414427, 1976. McKenzie LS, Horsburgh BA, Ghosh P and Taylor TKF: Osteoarthrosis: Uncertain rationale for anti-inflammatory drug therapy. Lancet 1(7965): 908909, 1976. McKenzie LS, Horsburgh BA, Ghosh P and Taylor TKF: Effect of antiinflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage. Ann. Rheum. Dis. 35(6): 487-497, 1976. Shinmei M, Ghosh P and Taylor TKF: N6,02'-Dibutyryl adenosine 3',5'monophosphate-stimulated release of proteoglycans from cultured immature rabbit ear cartilage. Biochim. Biophys. Acta 437: 94-105, 1976. Taylor TKF, Ghosh P, Braund KG, Sutherland JM and Sherwood AA: The effect of spinal fusion on intervertebral disc composition: An experimental study. J. Surg. Res. 21(2): 91-104, 1976. Braund KG, Taylor TKF, Ghosh P and Sherwood AA: Lateral spinal decompression in the dog. J. Sm. Anim. Pract. 17(9): 583-592, 1976. Stephens RW, Sutherland J, Ghosh P and Taylor TKF: Human serum and synovial fluid hyaluronidase - Bovine testicular hyaluronidase is not a valid substitute in drug evaluation studies. Biochem. Pharmacol. 25(13): 15071511, 1976. Ghosh P, Taylor TKF and Braund KG: The variation of the glycosaminoglycans of the canine intervertebral disc with ageing. I. Chondrodystrophoid breed. Gerontology 23: 87-98, 1977. Ghosh P, Taylor TKF and Braund KG: Variation of the glycosaminoglycans of the intervertebral disc with ageing. II. Non-chondrodystrophoid breed. Gerontology 23: 99-109, 1977. McKenzie LS, Horsburgh BA, Ghosh P and Taylor TKF: Sulphated glycosaminoglycan synthesis in normal and osteoarthrotic hip cartilage. Ann. Rheum. Dis. 36(4): 369-373, 1977. McKenzie LS, Horsburgh BA, Ghosh P and Taylor TKF: Organ culture of human articular cartilage: Studies on sulphated glycosaminoglycan synthesis. In Vitro 13(7): 423-428, 1977.
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Braund KG, Taylor TKF, Ghosh P and Sherwood AA: Spinal mobility in the dog. A study in chondrodystrophoid and non-chondrodystrophoid animals. Res. Vet. Sci. 22(1): 78-82, 1977. Harris PA, Stephens RW, Ghosh P and Taylor TKF: Endo- and exoglycosidases in an experimental rat osteosarcoma. Aust. J. Exp. Biol. Med. Sci. 55(4): 363-370, 1977. MacPhee DG, Robert GP, Ternai B, Ghosh P and Stephens R: Mutagenesis by 4-nitrobenzofurazans and furoxans. Chem. Biol. Interact. 19: 77-90, 1977. Burkhardt D, Stephens RW, Ghosh P and Taylor TKF: Inhibition of synovial fluid lysosomal glycosidases by anti-arthritic gold preparations. Agents Actions 8(3): 251-257, 1978. Bushell GR, Ghosh P, Taylor TKF, Sutherland JM and Braund KG: The effect of spinal fusion on the collagen and proteoglycans of the canine intervertebral disc. J. Surg. Res. 25: 61-69, 1978. Ghosh P, Taylor TKF, Bellenger C, Pettit G and Horsburgh B: Knee joint meniscal regeneration and post-meniscectomy arthropathy - An experimental study in the dog. Aust. N.Z. J. Med. 8: 34, 1978.
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Ghosh P: Lysosomal enzymes in joint disease. Aust. N.Z. J. Med. 8: 12-15, 1978. Stephens RW, Pemberton LI, Ghosh P and Taylor TKF: A radioassay for proteolytic cleavage of isolated cartilage proteoglycan. I. Separation principles and variables. Anal. Biochem. 90(2): 726-736, 1978. Dunn RI, Bolt AG, Ghosh P and Mrongovius RI: A novel activity cage for rats: Characterization of some phenylethylamine derivatives with central stimulant and depressant effects. Clin. Exp. Pharmacol. Physiol. 5: 627-633, 1978. Ghosh P, Bolt AG and Mrongovius RI: 1,2-Diphenylethylamines as potential non stimulant anorectics. Arzneim.-Forsch./Drug Res. 28(9): 1561-1564, 1978. Bushell GR, Ghosh P and Taylor TKF: Collagen defect in idiopathic scoliosis. Lancet 2: 94-95, 1978. Knight JA, Stephens RW, Bushell GR, Ghosh P and Taylor TKF: Neutral protease inhibitors from human intervertebral disc and femoral head articular cartilage. Biochim. Biophys. Acta 584(2): 304-310, 1979. Stephens RW, Ghosh P and Taylor TKF: The pathogenesis of osteoarthrosis. Med. Hypotheses 5(7): 809-816, 1979. Mrongovius RI, Ghosh P and Bolt AG: Anorectic and motor activity effects of some 1-Benzylcycloalkylamines in the rat. Clin. Exp. Pharmacol. Physiol. 6: 81-86, 1979. Bushell GR, Ghosh P, Taylor TKF and Sutherland JM: The collagen of the intervertebral disc in adolescent idiopathic scoliosis. J. Bone Joint Surg. Br. 61(4)B: 501-508, 1979. Ghosh P, Bushell GR, Taylor TKF, Pearce RH and Grimmer BJ: Distribution of glycosaminoglycans across the normal and the scoliotic disc. Spine 5(4): 310-317, 1980. Pettit GR, Bellenger CR, Taylor TKF and Ghosh P: Die Behandlung von Meniskuslsionen des Hundes. Kleintier Praxis, 25: 435-440, 1980. Stephens RW, Walton EA, Ghosh P, Taylor TKF, Gramse M and Havemann K: A radioassay for proteolytic cleavage of isolated cartilage proteoglycan. 2. Inhibition of human leukocyte elastase and cathepsin G by anti-inflammatory drugs. Arzneimittel-Forschung (Drug Res) 30(12): 2108-2112, 1980. Taylor TKF, Ghosh P and Bushell GR: The contribution of the intervertebral disk to the scoliotic deformity. Clin. Orthop. 156: 79-90, 1981. Walton EA, Upfold LI, Stephens RW, Ghosh P and Taylor TKF: The role of serine protease inhibitors in normal and osteoarthrotic human articular cartilage. Semin. Arthritis Rheum. 11 (Suppl. 1): 73-75, 1981. Walton EA, Stephens RW, Ghosh P and Taylor TKF: Nonsteroidal antiinflammatory drugs (NSAIDs) and articular cartilage integrity. Semin. Arthritis Rheum. 11 (Suppl. 1): 147-149, 1981.
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Mrongovius RI, Ghosh P, Bolt AG and Ternai B: 1-(2-Thienyl)-2phenylethylamines as potential non-stimulant anorectics. Arzneim.-Forsch. / Drug Res. 31(II) Nr.10: 1718-1720, 1981. Taylor TKF and Ghosh P: Anti-inflammatory drugs in the management of spondylosis. Br. Med. J. 283(6297): 951, 1981. Ghosh P, Taylor TKF and Meachin AD: A double blind crossover trial of indomethacin, flurbiprofen and placebo in the management of lumbar spondylosis. Curr. Ther. Res. 30(3): 318-326, 1981. Andrews JL, Ghosh P, Ternai B and Whitehouse MW: Ammonium 4-chloro-7sulfobenzofurazan: A new fluorigenic thiol-specific reagent. Arch. Biochem. Biophys. 214(1): 386-396, 1982. Burkhardt D, Ghosh P, Ternai B and Whitehouse MW: Effects of 4-nitro and 4-sulpho-7-substituted benzofurazans on nucleic acid and protein synthesis of a malignant fibrosarcoma cell line in combination with mild hyperthermia. Chem. Biol. Interact. 42(2): 195-207, 1982. Sinosich MJ, Davey MW, Ghosh P and Grudzinskas JG: Specific inhibition of human granulocyte elastase by human pregnancy associated plasma protein A. Biochem. Int. 5: 777-786, 1982. Golding JC and Ghosh P: Drugs for osteoarthrosis. I: The effects of pentosan polysulphate (SP54) on the degradation and loss of proteoglycans from articular cartilage in a model of osteoarthrosis induced in the rabbit knee joint by immobilization. Curr. Ther. Res. 33(2): 173-184, 1983. Golding J and Ghosh P: Drugs for osteoarthrosis. II: The effects of a glycosaminoglycan polysulphate ester (Arteparon) on proteoglycan aggregation and loss from articular cartilage of immobilized rabbit knee joints. Curr. Ther Res. 34(1): 67-80, 1983. Nakagawa T, Ghosh P and Nagai Y: Serine proteinase and serine proteinase inhibitors of normal and degenerate knee joint menisci. Biomed. Res. 4(1): 25-32, 1983. Hanspal JS, Bushell GR and Ghosh P: Detection of protease inhibitors using substrate-containing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Anal. Biochem. 132(2): 288-293, 1983. Ghosh P, Taylor TKF, Pettit GD, Horsburgh BA and Bellenger CR: Effects of postoperative immobilisation on the regrowth of the knee joint semilunar cartilage: An experimental study. J. Orthop. Res. 1: 153-164, 1983. Andrews JL, Ghosh P, Lentini A and Ternai B: The interaction of pentosan polysulphate (SP54) with human neutrophil elastase and connective tissue matrix components. Chem. Biol. Interact. 47(2): 157-173, 1983. Ghosh P, Sutherland JM, Taylor TKF, Pettit GD and Bellenger CR: The effects of postoperative joint immobilization on articular cartilage degeneration following meniscectomy. J. Surg. Res. 35(6): 461-473, 1983. Ghosh P, Sutherland JM, Taylor TKF, Bellenger CR and Pettit GD: The effect of bilateral medial meniscectomy on articular cartilage of the hip joint. J. Rheumatol. 11(2): 197-201, 1984.
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Lesjak MS and Ghosh P: Polypeptide proteinase inhibitor from human articular cartilage. Biochim. Biophys. Acta 789(3): 266-277, 1984. Frost L and Ghosh P: Microinjury to the synovial membrane may cause disaggregation of proteoglycans in rabbit knee joint articular cartilage. J. Orthop. Res. 2(3): 207-220, 1984. Andrews JL, Sutherland JM and Ghosh P: The distribution and binding of glycosaminoglycan polysulfate to intervertebral disc, knee joint articular cartilage and meniscus. Arzneimittelforschung (Drug Res.) 35(1): 144-148, 1985. Cole T-C, Burkhardt D, Ghosh P, Ryan M and Taylor T: Effects of spinal fusion on the proteoglycans of the canine intervertebral disc. J. Orthop. Res. 3: 277-291, 1985. Lentini A, Ternai B and Ghosh P: Synthetic inhibitors of human leukocyte elastase. Part 1. Sulphated polysaccharides. Biochem. Int. 10(2): 221-232, 1985. Cole T-C, Burkhardt D, Frost L and Ghosh P: The proteoglycans of the canine intervertebral disc. Biochem. Biophys. Acta 839(2): 127-138, 1985. Smith MM and Ghosh P: The effects of some polysulphated polysaccharides on hyaluronate (HA) synthesis by human synovial fibroblasts. Agents Actions 18 (Suppl.): 55-62, 1986. Cole T-C, Ghosh P and Taylor TKF: Variation of the proteoglycans of the canine intervertebral disc with ageing. Biochim. Biophys. Acta 880(2-3): 209219, 1986. Ghosh P, Andrews JL, Osborne RA and Lesjak MS: Variation with ageing and degeneration of serine and cysteine proteinase inhibitors of human articular cartilage. Agents Actions 18 (Suppl.): 69-81, 1986. Read R, Sutherland J and Ghosh P: The matrix components of epiphyseal growth plate and articular cartilages from dogs treated with ammonium tetrathiomolybdate, a copper antagonist. Aust. J. Exp. Biol. Med. Sci. 64(6): 545-562, 1986. Burkhardt D and Ghosh P: Laboratory evaluation of glycosaminoglycan polysulphate ester for chondroprotective activity: A review. Curr. Ther. Res. 40(6): 1034-1053, 1986. Burkhardt D and Ghosh P: Laboratory evaluation of antiarthritic agents as potential chondroprotective agents. Semin. Arthritis Rheum. 17(2) (Suppl. 1): 3-34, 1987. Hannan N, Ghosh P, Bellenger C and Taylor T: Systemic administration of glycosaminoglycan polysulphate (Arteparon) provides partial protection of articular cartilage from damage produced by meniscectomy in the canine. J. Orthop. Res. 5(1): 47-59, 1987. Melrose J, Ghosh P and Taylor TKF: Neutral proteinases of the human intervertebral disc. Biochim. Biophys. Acta 923(3): 483-495, 1987.
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Ghosh P, Collier S and Andrews J: Synovial membrane-cartilage interactions - The role of serine proteinase inhibitors in interleukin-1 mediated degradation of articular damage. J. Rheumatol. 14 (Suppl. 14): 122-124, 1987. Cole T-C, Ghosh P, Hannan NJ, Taylor TKF and Bellenger CR: The response of the canine intervertebral disc to immobilization produced by spinal arthrodesis is dependent on constitutional factors. J. Orthop. Res. 5(3): 337347, 1987. Cullis-Hill D and Ghosh P: The role of hyaluronic acid in joint stability - A hypothesis for hip dysplasia and allied disorders. Med. Hypotheses 23(2): 171-185, 1987. Smith MM and Ghosh P: The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment. Rheumatol. Int. 7(3): 113-122, 1987. Cook L, Ternai B and Ghosh P: Inhibition of human sputum elastase by substituted 2-pyrones. J. Med. Chem. 30: 1017-1023, 1987. Melrose J and Ghosh P: Low molecular weight serine proteinase inhibitors of the human intervertebral disc. Biochem. Int. 15(1): 117-125, 1987. Lentini A, Ternai B and Ghosh P: Synthetic inhibitors of human granulocyte elastase. Part 4. Inhibition of human granulocyte elastase and cathepsin G by non-steroidal anti-inflammatory drugs (NSAIDs). Biochem. Int. 15(6): 10691078, 1987. Cole T-C, Melrose J and Ghosh P: Cysteine proteinase inhibitors of the intervertebral disc. Biochim. Biophys. Acta 952(2): 201-207, 1988. Hutadilok N, Ghosh P and Brooks P: Binding of haptoglobin, inter-a-trypsin inhibitor and a1-proteinase inhibitor to synovial fluid hyaluronate and the influence of these proteins on its degradation by oxygen derived free radicals. Ann. Rheumatic. Dis. 47(5): 377-385, 1988. Lentini A, Ternai B and Ghosh P: Interaction of heparin and SP54 with gelatin. Int. J. Biol. Macromol. 10: 113-120, 1988. Melrose J and Ghosh P: The quantitative discrimination of corneal type I, but not skeletal type II keratan sulphate in glycosaminoglycan mixtures by using a combination of dimethylmethylene blue and endo-b-D-galactosidase digestion. Anal. Biochem. 170(2): 293-300, 1988. Collier S and Ghosh P: The role of plasminogen in interleukin-1 mediated cartilage degradation. J. Rheumatol. 15(7): 1129-1137, 1988. Hutadilok N, Smith MM, Cullis-Hill D, Brooks PM and Ghosh P: Pentosan polysulphate stimulates hyaluronate and DNA synthesis in synovial fibroblasts and partially reduces the suppressive effect of hydrocortisone on fibroblast metabolism. Curr. Ther. Res. 44(5): 845-860, 1988. Cole T-C, Melrose J and Ghosh P: Isolation and characterisation of a neutral proteinase from the canine intervertebral disc. Biochim. Biophys. Acta 990(3): 254-262, 1989.
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Ghosh P: Therapeutic modulation of cartilage catabolism by nonsteroidal antiinflammatory drugs (NSAIDs) in arthritis. Semin. Arthritis Rheum. 18 (Suppl. 1): 2-6, 1989. Francis DJ, Forrest MJ, Brooks PM and Ghosh P: Retardation of articular cartilage degradation by glycosaminoglycan polysulfate, pentosan polysulfate, and DH-40J in the rat air pouch model. Arthritis Rheum. 32(5): 608-616, 1989. Collier S and Ghosh P: Evaluation of the effects of antiarthritic drugs on the secretion of proteoglycans by lapine chondrocytes using a novel assay procedure. Ann. Rheum. Dis. 48(5): 372-381, 1989. Kongtawelert P and Ghosh P: An enzyme-linked immunosorbent-inhibition assay for quantitation of hyaluronan (hyaluronic acid) in biological fluids. Anal. Biochem. 178(2): 367-372, 1989. Kongtawelert P, Francis DJ, Brooks PM and Ghosh P: Application of an enzyme-linked immunosorbent inhibition assay to quantitate the release of KS peptides into fluids of rat subcutaneous air-pouch model and the effects of chondroprotective drugs on the release process. Rheumatol. Int. 9(2):77-83, 1989. Melrose J, Ghosh P and Taylor TKF: Lysozyme, a major low molecular weight cationic protein of the intervertebral disc, which increases with ageing and degeneration. Gerontology 35(4): 173-180, 1989. Kongtawelert P, Brooks PM and Ghosh P: Pentosan polysulfate (Cartrophen) prevents the hydrocortisone induced loss of hyaluronic acid and proteoglycan from cartilage of rabbit joints as well as normalizes the keratan sulfate levels in their serum. J. Rheumatol. 16(11): 1454-1459, 1989. Ghosh P: The role of serine proteinases and serine proteinase inhibitors in the pathobiology of connective Tissues. J. Jpn. Orthop. 63(5): 643-652, 1989. Ghosh P: Articular cartilage: What it is, Why it fails in osteoarthritis, and What can be done about it. Arthritis Care Res. 1(4): 211-221, 1989. Kongtawelert P and Ghosh P: A monoclonal antibody that recognizes 2,3-, 2,6-, and 4,6-disulphate ester ring substitution in pyranose-containing polysaccharides. Its production, characterization and application for the quantitation of pentosan polysulphate, dextran sulphate, glycosaminoglycan polysulphate and chondroitin sulphate E. J. Immunol. Methods 126(1): 39-49, 1990. Ghosh P, Wells C, Smith M and Hutadilok N: Chondroprotection, myth or reality: An experimental approach. Semin. Arthritis Rheum. 19(14) (Suppl. 1): 3-9, 1990. Ghosh P, Sutherland J, Bellenger C, Read R and Darvodelsky A: The influence of weight-bearing exercise on articular cartilage of meniscectomized joints. An experimental study in sheep. Clin. Orthop. 252: 101-113, 1990. Kongtawelert P and Ghosh P: A method for the quantitation of hyaluronan (hyaluronic acid) in biological fluids using a labeled avidin-biotin technique. Anal. Biochem. 185(2): 313-318, 1990.
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Andrews JL and Ghosh P: Low molecular weight serine proteinase inhibitors of human articular cartilage. Isolation, characterisation and biosynthesis. Arthritis Rheum. 33(9): 1384-1393, 1990. Kongtawelert P and Ghosh P: A new sandwich-ELISA method for the determination of keratan sulphate peptides in biological fluids employing a monoclonal antibody and labelled avidin biotin technique. Clin. Chim. Acta. 195(1-2): 17-26, 1990. Melrose J, Gurr KR, Cole T-C, Darvodelsky A, Ghosh P and Taylor TKF: The influence of scoliosis and ageing on proteoglycan heterogeneity in the human intervertebral disc. J. Orthop. Res. 9(1): 68-77, 1991. Ghosh P, Burkhardt D, Read R and Bellenger C: Recent advances in models for evaluating chondroprotective drugs. J. Rheumatol. 18(Suppl. 27): 143-146, 1991. Hutadilok N, Smith MM and Ghosh P: Effects of hydrogen peroxide on the metabolism of human rheumatoid and osteoarthritic synovial fibroblasts in vitro. Ann. Rheum. Dis. 50(4): 219-226, 1991. Collier S and Ghosh P: Comparison of the effects of non-steroidal antiinflammatory drugs (NSAIDs) on proteoglycan synthesis by articular cartilage explants and chondrocyte monolayer cultures. Biochem. Pharmacol. 41(9): 1375-1384, 1991. Meyer-Carrive I and Ghosh P: Effects of tiaprofenic acid (Surgam) on cartilage proteoglycans in the rabbit joint immobilisation model. Ann. Rheum. Dis. 51(4): 448-455, 1992. Ghosh P, Melrose J, Cole T-C and Taylor T: A comparison of the high buoyant density proteoglycans isolated from the intervertebral discs of chondrodystrophoid and non-chondrodystrophoid dogs. Matrix 12(2): 148155, 1992. Andrews JL, Melrose J and Ghosh P: A comparative study of the lowmolecular serine proteinase inhibitors of human connective tissues. Biol. Chem. Hoppe Seyler 373(3): 111-118, 1992. Melrose J, Ghosh P, Taylor TKF, Hall A, Osti OL, Vernon-Roberts B and Fraser RD: A longitudinal study of the matrix changes induced in the intervertebral disc by surgical damage to the annulus fibrosus. J. Orthop. Res. 10(5): 665-676, 1992. Melrose J and Ghosh P: Development of an avidin-biotin competitive inhibition assay and validation of its use for the quantitation of human intervertebral disc serine proteinase inhibitory proteins. Anal. Biochem. 204(2): 372-382, 1992. Nethery A, Giles I, Jenkins K, Jackson C, Brooks P, Burkhardt D, Ghosh P, Whitelock J, O'Grady RL, Welgus HG and Schrieber L: The chondroprotective drugs, Arteparon and sodium pentosan polysulphate, increase collagenase activity and inhibit stromelysin activity in vitro. Biochem. Pharmacol. 44(8): 1549-1553, 1992. Melrose J, Ghosh P, Taylor TKF and Andrews JL: The serine proteinase inhibitory proteins of the human intervertebral disc: Their isolation,
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characterization and variation with ageing and degeneration. Matrix 12(6): 456-470, 1992.
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Ghosh P: Non-steroidal anti-inflammatory drugs and chondroprotection: A review of the evidence. Drugs 46(5): 834-846, 1993. Hope N, Ghosh P, Taylor TKF, Sun D and Read R: Effects of intraarticular hyaluronan on matrix changes induced in the lateral meniscus by total medial meniscectomy and exercise. Semin. Arthritis Rheum. 22(6) (Suppl. 1): 43-51, 1993. Ghosh P, Read R, Armstrong S, Wilson D, Marshall R and McNair P: The effects of intra-articular administration of hyaluronan in a model of early osteoarthritis in sheep. I. - Gait analysis, radiological and morphological studies. Semin. Arthritis Rheum. 22(6) (Suppl. 1): 18-30, 1993. Ghosh P, Read R, Numata Y, Smith S, Armstrong S and Wilson D: The effects of intra-articular administration of hyaluronan in a model of early osteoarthritis in sheep. II. Cartilage composition and proteoglycan metabolism. Semin. Arthritis Rheum. 22(6) (Suppl. 1): 31-42, 1993. Armstrong SJ, Read RA, Ghosh P and Wilson DM: Moderate exercise exacerbates the osteoarthritic lesions produced in cartilage by meniscectomy: A morphological study. Osteoarthritis Cartilage 1: 89-96, 1993. Ghosh P: Osteoarthritis and hyaluronan: Palliative or disease modifying treatment? Semin. Arthritis Rheum. 22(6) (Suppl. 1): 1-3, 1993. Melrose J, Ghosh P: Determination of the average molecular size of glycosaminoglycans by fast protein liquid chromatography. J Chromatogr. 637: 91-95, 1993. Ghosh P and Smith M: The role of cartilage-derived antigens, pro-coagulant activity and fibrinolysis in the pathogenesis of osteoarthritis. Med. Hypotheses 41(2): 190-194, 1993. Francis DJ, Hutadilok N, Kongtawelert P and Ghosh P: Pentosan polysulphate and glycosaminoglycan polysulphate stimulates the synthesis of hyaluronan in vivo. Rheumatol. Int. 13(2): 61-64, 1993. Meyer-Carrive I, Graham GG and Ghosh P: Pharmacokinetics of tiaprofenic acid in normal rabbits and rabbits subjected to joint immobilization. Agents Actions 39: 59-68, 1993. Jacoby AS, Melrose J, Robinson BG, Hyland VJ and Ghosh P: Secretory leukocyte proteinase inhibitor is produced by human articular cartilage chondrocytes and intervertebral disc fibrochondrocytes. Eur. J. Biochem. 218(3): 951-957, 1993. Bansal MK, Smith MM, Numata Y and Ghosh P: The effects of calcium pentosan polysulphate on inflammatory mediators in the rat air-pouch model of inflammation. Curr. Ther. Res. 54(6): 714-730, 1993. Ghosh P, Wells C, Numata Y, Read R and Armstrong S: The effects of orally administered tiaprofenic acid on the biosynthesis of proteoglycans in ex vivo cartilage cultures from joints of animals with early osteoarthritis. Curr. Ther. Res. 54(6): 703-713, 1993.
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Smith MM, Ghosh P, Numata Y and Bansal MK: The effects of orally administered calcium pentosan polysulfate on inflammation and cartilage degradation produced in rabbit joints by intraarticular injection of a hyaluronate-polylysine complex. Arthritis Rheum. 37(1): 125-136, 1994. Ghosh P: The role of hyaluronic acid (hyaluronan) in health and disease: Interactions with cells, cartilage and components of synovial fluid. Clin. Exp. Rheumatol. 12(1): 75-82, 1994. Melrose J, Ghosh P and Taylor TKF: Proteoglycan heterogeneity in the normal adult ovine intervertebral disc. Matrix Biol. 14(1): 61-75, 1994. Melrose J, Ghosh P and Jacoby A: A solid phase enzyme linked immunofiltration assay for secretory leucocyte proteinase inhibitor. Clin. Chem. Acta 225: 17-28, 1994. Armstrong S, Read R and Ghosh P: The effects of intraarticular hyaluronan on cartilage and subchondral bone changes in an ovine model of early osteoarthritis. J. Rheumatol. 21(4): 680-688, 1994. Ghosh P, Hutadilok N and Lentini A: Nuclear magnetic resonance studies of hyaluronan (HA): Evidence of competitive inhibition of interchain associations by phospholipids which may result in decreased anti-inflammatory and cartilage protecting properties of HA. Heterocycles 38: 1757-1774, 1994. Theiler R, Ghosh P and Brooks P: Clinical assessment methods in osteoarthritis and clinical trials with chondromodulating agents. Osteoarthritis Cartilage 2: 1-23, 1994. Melrose J, Ghosh P, Taylor TKF and McAuley L: A comparative study of the composition of discs and of proteoglycans from different spinal levels of sheep. Vet. Comp. Orthop. Traumatol. 7: 70-76, 1994. Melrose J, Rodgers K and Ghosh P: The preparation and use of biotinylated trypsin and its use in Western blotting for the detection of trypsin inhibitory proteins. Anal. Biochem. 222: 34-43, 1994. Ghosh P, Hutadilok N, Adam N and Lentini A: Interactions of hyaluronan (hyaluronic acid) with phospholipids as determined by gel permeation chromatography, multi-angle laser-light scattering photometry and 1H-NMR spectroscopy. Int. J. Biol. Macromol. 16(5): 237-244, 1994. Ghosh P, Holbert C, Read R and Armstrong S: Hyaluronic acid (hyaluronan) in experimental osteoarthritis. J. Rheumatol. 22 (Suppl. 43): 155-157, 1995. Melrose J, Hall A, Macpherson C, Bellenger CR and Ghosh P: Evaluation of digestive proteinases from the Antarctic Krill Euphasia Superba, as potential chemonucleolytic agents. In vitro and in vivo studies. Arch. Orthop. Trauma Surg. 114(3): 145-152, 1995. Rodgers KJ, Melrose J and Ghosh P: Biotin-labeled potato chymotrypsin inhibitor-1: A useful probe for the detection and quantitation of chymotrypsinlike serine proteinases on western blots and its application in the detection of a serine proteinase synthesised by articular chondrocytes. Anal. Biochem. 227: 129-134, 1995.
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Collier S and Ghosh P: Effects of transforming growth factor beta on proteoglycan synthesis by cell and explant cultures derived from the knee joint meniscus. Osteoarthritis Cartilage 3(2): 127-138, 1995. Melrose J, Ghosh P and Patel M: Biotinylated aprotinin: A versatile probe for the detection of serine proteinases on Western blots. Int. J. Biochem. Cell Biol. 27(9): 891-904, 1995. Melrose J, Numata Y and Ghosh P: Biotinylated hyaluronan: A versatile and highly sensitive probe capable of detecting nanogram levels of hyaluron binding proteins (hyaladherins) on electroblots by a novel affinity detection procedure. Electrophoresis 17: 205-212, 1996. Rodgers KJ, Melrose J and Ghosh P: Biotinylated trypsin and its application as a sensitive, versatile probe for the detection and characterisation of an ovine chondrocyte serine proteinase inhibitor using Western blotting. Electrophoresis 17: 213-218, 1996. Patel MI, Ghosh P, Melrose J and Appleberg M: Smooth muscle cell migration and proliferation is enhanced in abdominal aortic aneurysms. Aust. N.Z. J. Surg. 66(5): 305-308, 1996. Collier S, Hope N and Ghosh P: Healing of circular defects in the rabbit medial meniscus can occur spontaneously and not improved by intra-articular hyaluronic acid. Vet. Comp. Orthop. Traumatol. 9(2): 60-65, 1996. Patel MI, Melrose J, Ghosh P and Appleberg M: Increased synthesis of matrix metalloproteinases by aortic smooth muscle cells is implicated in the etiopathogenesis of abdominal aortic aneurysms. J. Vasc. Surg. 24(1): 82-92, 1996. Melrose J, Taylor TKF, Ghosh P, Holbert C, Macpherson C and Bellenger CR: Intervertebral disc reconstitution after chemonucleolysis with chymopapain is dependent on dosage. An experimental study in beagle dogs. Spine 21(1): 9-17, 1996. Little C, Ghosh P and Bellenger CR: Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: An experimental study in sheep. J. Orthop. Res. 14(3): 433-444, 1996. Ghosh P and Hutadilok N: Interactions of pentosan polysulfate with cartilage matrix proteins and synovial fibroblasts derived from patients with osteoarthritis. Osteoarthritis Cartilage 4(1): 43-53, 1996. Melrose J, Taylor TKF and Ghosh P: Variation in intervertebral disc serine proteinase inhibitory proteins with ageing in a chondrodystrophoid (beagle) and non-chondrodystrophoid (greyhound) canine breed. Gerontology 42: 322329, 1996. Rodgers K, Melrose J and Ghosh P: Purification and characterisation of 6 and 58 kDa forms of the endogenous serine proteinase inhibitory proteins of ovine articular cartilage. Biol. Chem. Hoppe Seyler 377: 837-845, 1996. Smith MM, Little CB, Rodgers K and Ghosh P: Animal models used to evaluate anti-osteoarthritis drugs. Pathol. Biol. [Paris] 45(4): 313-320, 1997.
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Melrose J, Ghosh P, Taylor TKF, Latham J and Moore R: Topographical variation in the catabolism of aggrecan in an ovine annular lesion model of experimental disc degeneration. J. Spinal Disord. 10(1): 55-67, 1997. Little C, Ghosh P and Rose R: The effect of strenuous versus moderate exercise on the metabolism of proteoglycans in different weight-bearing regions of the equine third carpal bone. Osteoarthritis Cartilage 5(3): 161-172, 1997. Little C and Ghosh P: Variation in proteoglycan metabolism by articular chondrocytes in different joint regions is determined by post-natal mechanical loading. Osteoarthritis Cartilage 5(1): 49-62, 1997. Anderson JM, Edelman J and Ghosh P: The effects of pentosan polysulphate on peripheral blood leukocyte populations and monocyte procoagulant activity in patients with osteoarthritis. Curr. Ther. Res. 58: 93-107, 1997. Melrose J, Taylor TKF and Ghosh P: The serine proteinase inhibitory proteins of the chondrodystrophoid (beagle) and non-chondrodystrophoid (greyhound) canine intervertebral disc. Electrophoresis 18(7): 1059-1063, 1997. Little C, Smith S, Ghosh P and Bellenger CR: Histomorphological and immunohistochemical evaluation of the joint changes in a model of osteoarthritis induced by lateral meniscectomy in sheep. J. Rheumatol. 24(11): 2199-2209, 1997. Pasquali-Ronchetti I, Quaglino D, Mori G, Bacchelli B and Ghosh P: Hyaluronan - Phospholipid interactions. J. Struct. Biol. 120(1): 1-10, 1997. Melrose J, Ghosh P, Taylor TKF, Vernon-Roberts B, Latham J and Moore R: Elevated synthesis of biglycan and decorin in an ovine annular lesion model of experimental disc degeneration. Eur. Spine J. 6(6): 376-384, 1997. Melrose J, Little CB and Ghosh P: Detection of aggregatable proteoglycan populations by affinity blotting using biotinylated hyaluronan. Anal. Biochem. 256(2): 149-157, 1998. Melrose J, Whitelock J, Xu Q and Ghosh P: Pathogenesis of abdominal aortic aneurysms: Possible role of differential production of proteoglycans by smooth muscle cells. J. Vasc. Surg. 28(4): 676-686, 1998. Ghosh P, Xu A, Hwa S-Y, Burkhardt D and Little C: Evaluation of the protective effects of diacerhein on cartilage and subchondral bone in an ovine model of osteoarthritis. Revue du Praticien 48(Suppl. 17): S24-30, 1998. Simpson DS, Bellenger CR, Ghosh P, Numata Y and Little C: The effect of total meniscectomy versus caudal pole hemimeniscectomy on the stifle joint of the sheep. V.C.O.T. 12(2): 56-63, 1999. Francis DJ, Andrews BA, Brooks PM and Ghosh P: Chondroprotective effect of extracts of normal human articular cartilage on matrix degradation in rat subcutaneous air-pouch model of inflammation. APLAR J. Rheumatol. 3: 298305, 1999. Ghosh P: Evaluation of disease progression during nonsteroidal antiinflammatory drug treatment - Experimental models. International
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Federation of Societies on Skeletal Diseases. New York, USA, 23-24 May 1998. Osteoarthritis Cartilage 7(3): 340-342, 1999.
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Appleyard RC, Ghosh P and Swain MV: Biomechanical, histological and immunohistological studies of patellar cartilage in an ovine model of osteoarthritis induced by lateral meniscectomy. Osteoarthritis Cartilage 7(3): 281-294, 1999. Smith MM, Numata Y and Ghosh P: Effects of calcium pentosan polysulfate on joint inflammation and pouch fluid levels of leukocytes, nitric oxide and interleukin-6 in a rat model of arthritis. Current Therapeutic Research 60(11): 561-576, 1999. Micklethwaite L, Ghosh P, Little CB, Hodgson DR and Rose RJ: Proteoglycan composition and biosynthesis in superficial and deep digital flexor tendons of standardbred horses. V.C.O.T. 12: 166-1999. Takizawa M, Ohuchi E, Yamanaka H, Nakamura H, Ikeda E, Ghosh P and Okada Y: Production of tissue inhibitor of metalloproteinases 3 is selectively enhanced by calcium pentosan polysulfate in human rheumatoid synovial fibroblasts. Arthritis Rheum. 43(4): 812-820, 2000. Melrose J, Smith S and Ghosh P: Differential expression of proteoglycan epitopes by ovine intervertebral disc cells. J. Anat. 197(pt. 2): 189-198, 2000. Melrose J, Smith S, Rodgers K, Little C, Burkhardt D and Ghosh P: Immunolocalisation of BPTI-like serine proteinase inhibitory proteins in mast cells, chondrocytes and intervertebral disc fibrochondrocytes of ovine and bovine connective tissues. An immunohistochemical and biochemical study. Histochem. Cell Biol. 114(2): 137-146, 2000. Taylor TKF, Melrose J, Burkhardt D, Ghosh P, Claes LE, Kettler A and Wilke H-J: Spinal biomechanics and aging are major determinants of the proteoglycan metabolism of intervertebral disc cells. Spine 25(23): 30143020, 2000. Cake MA, Read RR and Ghosh P: Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU). Osteoarthritis Cartilage 8(6): 404-411, 2000. Edelman J, Hanrahan P and Ghosh P: Deer antler cartilage in the treatment of arthritis: Results of a 6 month placebo-controlled double-blind study with Cervusen in 54 patients with osteoarthritis. APLAR J. Rheumatol. 4(2): 95100, 2000. Melrose J, Ghosh P and Taylor TKF: A comparative analysis of the differential spatial and temporal distributions of the large (aggrecan, versican) and small (decorin, biglycan, fibromodulin) proteoglycans of the intervertebral disc. J. Anat. 198: 3-15, 2001. Melrose J, Smith S, Ghosh P and Taylor TKF: Differential expression of proteoglycan epitopes and growth characteristics of intervertebral disc cells grown in alginate bead culture. Cells Tissues Organs 168(3): 137-146, 2001.
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Degenhardt M, Ghosh P and Watzig H: Studies on the structural variations of pentosan polysulphate sodium (NaPPS) from different sources by capillary electrophoresis. Arch. Pharm. Pharm. Med. Chem. 334: 27-29, 2001. Hwa S-Y, Burkhardt D, Little C and Ghosh P: The effects of orally administered Diacerhein on cartilage and subchondral bone in an ovine model of osteoarthritis. J. Rheumatol. 28(4): 825-834, 2001. Burkhardt D, Hwa S-Y and Ghosh P: A novel microassay for the quantitation of the sulfated glycosaminoglycan content of histological sections: Its application to determine the effects of Diacerhein on cartilage in an ovine model of osteoarthritis. Osteoarthritis Cartilage 9: 238-247, 2001. Pattison ST, Melrose J, Ghosh P and Taylor TKF: Regulation of galatinase-A (MMP-2) production by ovine intervertebral nucleus pulposus cells grown in alginate bead culture by transforming growth factor-b1 and insulin like growth factor-I. Cell Biol. Int. 25(7): 679-689, 2001. Adam N and Ghosh P: Hyaluronan molecular weight and polydispersity in some commercial intra-articular injectable preparations and in synovial fluid. Inflamm. Res. 50(6): 294-299, 2001. Melrose J, Shen B and Ghosh P: Affinity and Western blotting reveal homologies between ovine intervertebral disc serine proteinase inhibitory proteins and bovine pancreatic trypsin inhibitor. Proteomics 1(12): 1529-1533, 2001. Fuller CJ, Ghosh P and Barr AR: Plasma and synovial fluid concentrations of calcium pentosan polysulphate achieved in the horse following intramuscular injection. Equine Vet. J. 34(1): 61-64, 2002. Melrose J, Smith S and Ghosh P: Synthesis of a kunitz-type serine proteinase inhibitory protein that shares homology with bovine pancreatic trypsin inhibitor by ovine intervertebral disc cells in serum-free alginate bead culture. J. Spinal Disord. Tech. 15(2): 164-171, 2002. Ghosh P and Smith M: Osteoarthritis, genetic and molecular mechanisms. Biogerontology 3(1-2): 85-88, 2002. Melrose J, Roberts S, Smith S, Menage J and Ghosh P: Increased nerve and blood-vessel ingrowth associated with proteoglycan depletion in an ovine annular lesion model of experimental disc degeneration. (ISSLS Special Societal Issue) Spine 27(12): 1278-1285, 2002. Melrose J, Smith S, Little CB, Kitson J, Hwa S-Y and Ghosh P: Spatial and temporal localization of transforming growth factor-, fibroblast growth factor2, and osteonectin, and identification of cells expressing -smooth muscle actin in the injured annulus fibrosus. Implications for extracellular matrix repair. Spine 27(16): 1756-1764, 2002. Shen B, Melrose J and Ghosh P: Induction of matrix metalloproteinase-2 and -3 activity in nucleus pulposus cells grown in three-dimensional agarose gel culture by interleukin-1: A potential pathway of disc degeneration. Eur. Spine J. 12: 66-75, 2003.
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Shen B, Shimmon S, Smith MM and Ghosh P: Biosensor analysis of the molecular interactions of pentosan polysulfate and of sulfated glycosaminoglycans with immobilized elastase, hyaluronidase and lysozyme using surface plasmon resonance (SPR) technology. J. Pharm. Biomed. Anal. 31: 83-93, 2003. Appleyard RC, Burkhardt D, Ghosh P, Read R, Cake M, Swain MV and Murrell GAC: Topographical analysis of the structural, biochemical and dynamic biomechanical properties of cartilage in an ovine model of osteoarthritis. Osteoarthritis Cartilage 11: 65-77, 2003. Ghosh P: Osteoarthritis 2002 and Beyond. APLAR J. Rheumatol. 6(1): 7984. 2003. Parker D, Hwa S-Y, Sambrook P and Ghosh P: Estrogen replacement therapy mitigates the loss of joint cartilage proteoglycans and bone mineral density induced by ovariectomy and osteoarthritis. APLAR J. Rheumatol. 6(2): 116-127, 2003. Melrose J, Smith S, Ghosh P and Whitelock J: Perlecan, the multidomain heparan sulfate proteoglycan of basement membranes, is also a prominent component of the cartilaginous primordia in the developing human fetal spine. J. Histochem. Cytochem. 51(10): 1331-1341, 2003. Cake MA, Read RA, Smith SM and Ghosh P: Topical administration of the nitric oxide donor glyceryl trinitrate modifies the structural and biomechanical properties of ovine articular cartilage. Osteoarthritis Cartilage 11:872-878, 2003. Hannon RL, Smith JG, Cullis-Hill D, Ghosh P and Cawdery MJ: Safety of Cartrophen-Vet in the dog: A review of adverse reaction reports in the UK. J Small Animal Practice. 44: 202-208, 2003. Melrose J, Smith S, Ghosh P and Taylor TKF: Comparison of the morphology and growth characteristics of intervertebral disc cells, synovial fibroblasts and articular chondrocytes in monolayer and alginate bead cultures. Eur. Spine J. (in press). Melrose J, Smith S and Ghosh P: Assessment of the cellular heterogeneity of the ovine intervertebral disc: Comparison with synovial fibroblasts and articular chondrocytes. Eur. Spine J. 12: 57 65. 2003. Melrose J, Smith S and Ghosh P. Histological and immunohistological studies on cartilage. Methods Mol Med. 101: 39 63, 2004. Oakley SP, Lassere MN, Portek I, Szomor Z, Ghosh P, Kirkham BW, Murrell GAC, Smith S, Wulf S and Appleyard RC: Biomechanical, histologic and macroscopic assessment of articular cartilage in a sheep model of osteoarthritis. Osteoarthritis Cartilage. 12:667 79, 2004. Cake MA, Read RA, Appleyard RC, Hwa SY and Ghosh P. The nitric oxide donor glyceryl trinitrite increases subchondral bone sclerosis and cartilage degeneration following ovine meniscectomy. Osteoarthritis and Cartilage. 12: 974 81, 2004. Oakley SP, Portek I, Szomor Z, Appleyard RC, Ghosh P, Kirkham BW, Murrell GA, Lassere MN. Arthroscopy a potential gold standard for the
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diagnosis of the chondropathy of early osteoarthritis. Osteoarthritis and Cartilage. 13: 368 78, 2005.
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Young AA, Smith MM, Cake MA, Ghosh P, Read RA, Melrose J, Sonnabend DH and Little CB. Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Research Ther. 7: R852 61, 2005. Ghosh P, Shimmon S, Whitehouse, The immunological basis for inflammation and cartilage destruction in osteoarthritis. New opportunities for therapeutic intervention. Reumatismo, 57: 110-112. 2005. Ghosh P, Edelman J, March L and Smith M. Effects of pentosan polysulfate in osteoarthritis of the knee: a randomized, double blind, placebo-controlled pilot study. Current Ther Research. 66: 552 571, 2005. Oakley SP, Portek I, Szomor Z, Appleyard RC, Ghosh P, Kirkham BW, Murrell GA, Lassere MN. Arthroscopic estimation of the extent of chondropathy. Osteoarthritis and Cartilage. Dec 21, 2006. Ghosh P, Shimmon S and Whitehouse M. Arthritic disease suppression and cartilage protection with glycosaminoglycan peptide complexes (Peptacans) derived from the cartilage extracellular matrix. Inflammopharmacology. 14: 161- 68, 2006.
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Major Reviews Burkhardt D and Ghosh P: Hyperthermia and cancer. Aust. N.Z. J. Surg. 47(5): 571-576, 1977. Bushell GR, Ghosh P, Taylor TKF and Akeson WH: Proteoglycan chemistry of the intervertebral disks. Clin. Orthop. 129: 115-123, 1977. Ghosh P, Bushell GR, Taylor TKF and Akeson WH: Collagens, elastin and noncollagenous protein of the intervertebral disk. Clin. Orthop. 129: 124-132, 1977. Akeson WH, Woo SL-Y, Taylor TKF, Ghosh P and Bushell GR: Biomechanics and biochemistry of the intervertebral disks: The need for correlation studies. Clin. Orthop. 129: 133-140, 1977. Ghosh P and Taylor TKF: The knee joint meniscus. A fibrocartilage of some distinction. Clin. Orthop. 224: 52-63, 1987. Ghosh P: Du Rolle von mechanischen und genetischen Faktoren in der Degeneration der Band scheibe. Manuelle Medizin 29: 21-25, 1991. Ghosh P: Osteoarthritis: Aetiopathogenesis and management. Mod. Med., 6880, 1991. Little C and Ghosh P: Structural and functional changes in articular cartilage with aging, mechanical loading and osteoarthritis. Aust. Musculoskeletal Med. 1: 14-25, 1996. Smith MM and Ghosh P: Osteoarthritis: Current status and future directions. APLAR J. Rheumatol. 2(1): 27-53, 1998. Ghosh P: The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment. Semin. Arthritis Rheum. 28(4): 211267, 1999. Ghosh P and Guidolin D: Mechanism of action of intra-articular hyaluronan in osteoarthritis: Are its effects molecular weight dependent? Semin. Arthritis Rheum. 32(1): 10-37, 2002. Other Articles Taylor TKF and Ghosh P: The disc factor in back strain. Special publication of Royal Australasian College of Surgeons. Seminars on Occupational Injuries, 1973. Gosh P (sic) and Taylor TKF: The reactions of connective tissue to physical stress. Chapter 9 "Strains at Work" Special publication of Royal Australasian College of Surgeons. Seminars on Occupational Injuries, 1973. Ghosh P: Osteoarthritis and future prospects for management. SEAPAL Bulletin 6: 29-33, 1988.
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(viii) Patents
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Cullis-Hill D and Ghosh P: Anti-inflammatory Compounds and Compositions, US 5,668,116, Sept 1997. Roubin R and Ghosh P: "Matrix gene expression in chondrogenesis". Australian Patent Provisional Application no. PP 8197, 15 February 2002. Assigned to the University of Sydney and ADP Pharmaceuticals Pty. Limited. Shen B and Ghosh P: Nutraceuticals for the treatment, protection and restoration of connective tissues. International Publication Number: WO 03/062279, (July 2003). Ghosh P: Connective Tissue derived Polypeptides. International Publication Number: WO 2004/110475, (December 2004). Ghosh P: Glycosaminoglycan peptides derived from connective tissues and use thereof in the prevention of arthritis and other anti-inflammatory conditions. Australian Patent Provisional Application 2004900250, (January 2004)
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Refereed and Published Conference Papers Gale CA, Ghosh P, Robinson RG, Stephens RW, Swann JC, Taylor TKF and Webb J: The origins and relative distribution of lysosomal enzymes in rheumatoid and osteoarthritic fluids. Aust. N.Z. J. Med. 3: 59, 1975. Harris P, Ghosh P and Taylor TKF: Studies on the level of polysaccharidases of rat osteosarcoma cells in vitro and in vivo. Clin. Exp. Pharmacol. 2(1): 85, 1975. Horsburgh BA, McKenzie LS, Ghosh P and Taylor TKF: Actions of antiinflammatory drugs on the synthesis of acid mucopolysaccharides in human osteoarthritic cartilage in vitro. Clin. Exp. Pharmacol. 2(1): 88, 1975. Ingman AM, Ghosh P and Taylor TKF: The rationale of meniscectomy in osteoarthritis and rheumatoid arthritis of the knee joint. J. Bone Joint Surg. Br. 57(2)B: 250, 1975. Stephens RW, Ghosh P and Taylor TKF: The inhibitory effects of antiinflammatory drugs and cations on hyaluronic acid degradation by serum and pathological synovial fluid. Clin. Exp. Pharmacol. 2(1): 87, 1975. Burkhardt D, Stephens RW, Ghosh P and Taylor TKF: The inhibition of synovial-fluid glycosidases in the rheumatoid joint by metallothiomalates. Biochem. Soc. Trans. 4: 1081, 1976. Ghosh P, Bushell GR, Taylor TKF and Sutherland JM: Characterisation of the proteoglycans of the canine nucleus pulposus and annulus fibrosus. Trans. Orthop. Res. Soc. 2: 10, 1977. Ghosh P, Taylor TKF, McKenzie LS and Horsburgh BA: Comparison of the synthesis and levels of glycosaminoglycans in aged and osteoarthrotic hip cartilages. Trans. Orthop. Res. Soc. 2: 9, 1977.
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Hwa S, Smith M, Burkhardt D and Ghosh P: Oestrogen depletion provokes significant vascular and matrix changes in the calcified cartilage and subchondral bone of the femoral-tibial joints of aged ewes. Trans. Orthop. Res. Soc. 47th Annual Meeting, p0373, 2001. Cake MA, Read RA, Hwa S-Y and Ghosh P: Glyceryl trinitrate increases subchondral bone thickness and density in an ovine meniscectomy model of osteoarthritis. 6th World Congress on Osteoarthritis - OsteoArthritis Research Society International, Washington, DC, USA, 30 September - 3 October 2001. Osteoarthritis Cartilage 9 (Suppl. B): S54, 2001. Smith MM, Cake M, Smith SM, Hwa S-Y, Burkhardt D and Ghosh P: The effects of calcium pentosan polysulfate on synovial pathology, nitric oxide synthase expression and hyaluronan production in an ovine model of osteoarthritis. 6th World Congress on Osteoarthritis - OsteoArthritis Research Society International, Washington, DC, USA, 30 September - 3 October 2001. Osteoarthritis Cartilage 9 (Suppl. B): S4, 2001. Hwa S-Y, Smith MM, Sambrook P and Ghosh P: The protective effects of calcium pentosan polysulfate on calcified cartilage integrity in the medial compartment of joints of an ovine model of osteoarthritis. 6th World Congress on Osteoarthritis - OsteoArthritis Research Society International, Washington, DC, USA, 30 September - 3 October 2001. Osteoarthritis Cartilage 9 (Suppl. B): S13, 2001. Cake M, Appleyard R, Read R, Ghosh P, Swain M and Murrell G: Effects of topical glyceryl trinitrate on femoro-tibial articular cartilage and subchondral bone in normal and ovariectomized sheep. Trans. Orthop. Res. Soc. 48th Annual Meeting, 0154, 2002. Appleyard R, Burkhardt D, Ghosh P, Read R, Cake M, Swain MV and Murrell GAC: Topographical relationships between cartilage biochemical and dynamic biomechanical properties in an ovine model of osteoarthritis. Trans. Orthop. Res. Soc. 48th Annual Meeting, 0667, 2002. Appleyard RC, Szomor ZL, Ghosh P, Swain MV and Murrell GAC: Loss of proteoglycans from articular cartilage increases dynamic phase lag but does not affect shear modulus: Application of a novel arthroscopic indentation device. Trans. Orthop. Res. Soc. 48th Annual Meeting, 0396, 2002. Ghosh P, Kipic B, Smith MM, Burkhardt D, Swain M, Cake M and Read R: The viscosity and elasticity of synovial fluids from osteoarthritic joints are improved 5 weeks post treatment by 5 intra-articular injections of hyaluronan with a molecular weight (MW) of 500 - 730 kDa but not by a preparation with MW of 3000 - 6900 kDa. European Congress of Rheumatology (EULAR) Annual Meeting, Stockholm, Sweden, 12-15 June 2002. Ann. Rheum. Dis. 61 (Suppl. 1): 116-117, 2002. Read R and Ghosh P: Intra-articular hyaluronan: A disease modifying therapy? APLAR J. Rheumatol. 5(1): A5-A6, 2002. Ghosh P: The challenges associated with the biologic repair of cartilage defects. APLAR J. Rheumatol. 5(1): A2-A3, 2002. Oakley SP, Appleyard RC, Ghosh P, Szomor Z, Portek I, Kirkham B and Lassere MN: The relationship between stiffness (shear modulus), thickness
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and histologic grading of cartilage using different scoring methods. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S23[PS10], 2002.
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Oakley SP, Ghosh P, Szomor Z, Portek I, Kirkham B and Lassere MN: Cellular and matrix changes exist throughout the stifle joint after medial meniscectomy - Evaluation of responsiveness of a new histological method of assessment. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S22[PS09], 2002. Oakley SP, Ghosh P, Szomor Z, Portek I, Kirkham B and Lassere MN: Evaluation of reliability of a new histological method of assessing osteoarthritic cartilage. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S23[PO11], 2002. Roubin R, Ghosh P, Robinson B, Goomer R and Amiel D: A novel gene product derived from deer antler chondrocytes stimulates mitogenesis when transfected into rabbit chondrocytes. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S41[PS64], 2002. Cake MA, Read RA, Smith SM and Ghosh P: Ovariectomy increases nitric oxide production in ovine patellar cartilage. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S9[M24], 2002. Smith MM, Pradhananga S and Ghosh P: Calcium pentosan polysulfate increases both concentration and molecular weight of hyaluronan synthesised by human osteoarthritic synovial fibroblasts in vitro. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S50[PS91], 2002. Smith MM, Burkhardt D, Smith SM, Cake M, Read RA and Ghosh P: The effects of intraarticular hyaluronan on synovial pathology, nitric oxide synthase expression and hyaluronan production in an ovine model of osteoarthritis. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S55[PS107], 2002. Smith MM, Ghosh P, Kipic B, Burkhardt D, Swain M, Cake M and Read R: The quantity and quality of hyaluronan in synovial fluids from osteoarthritic sheep are improved by intra-articular Hyalgan treatment. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S56[PS108], 2002. Shen B, Shimmon S, Smith MM and Ghosh P: Discovery and evaluation of potential disease modifying anti-osteoarthritis drugs using surface plasmon resonance technology. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S4[M09], 2002. Hwa S-Y, Burkhardt D, Smith SM, Smith MM and Ghosh P: The protective effects of calcium pentosan polysulfate on articular cartilage and subchondral
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bone in the medial compartment of joints in an ovine model of osteoarthritis induced by lateral meniscectomy. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S21[PS05], 2002.
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Bagga H, Burkhardt D, Morris D, Ghosh P and March L: Effect of intraarticular hylan GF-20 (Synvisc) on synovial fluid and clinical parameters. OsteoArthritis Research Society International, Sydney, NSW, Australia, 22-25 September 2002. Osteoarthritis Cartilage 10 (Suppl. A): S69[PS149], 2002. Melrose J, Smith S, Ghosh P and Whitelock J: Perlecan, the multi-domain, heparan sulphate basal lamina proteoglycan, is also a prominent peri- and extra-cellular matrix component in the developing vertebral body and intervertebral disc of the foetal human spinal column. (submitted Orthop. Res. Soc. Meeting, February 2003). Ghosh P, Shen B, Shimmon S and Smith M: A new technology for the discovery and evaluation of anti-arthritic agents using surface plasmon resonance (SPR). APLAR J. Rheumatol. (accepted for publication). Oakley SP, Szomor Z, Ghosh P, Portek I, Lassere MN, Kirkham BW, Murrell GAC and Appleyard R: Reduction in collagen organization and stiffness during early state osteoarthritis: A study in sheep. Trans. Orthop. Res. Soc. 49th Annual Meeting, 2003. Ghosh P, Shimmon S, Whitehouse M: A novel Glycosaminoglycan polypeptide complex, Peptacan, suppresses joint inflammation anf preserves cartilage in rat mosdels of arthritis given orally either as a toleragen or as a therapeutic agent. Osteoarthritis Cartilage 12 (Suppl. B): [P189], 2004. Ghosh P, Shen B, Wei X,: Functional characterisation of the novel gene hDACC-7 A prologue for gene therapy for the repair of articular cartilage. Osteoarthritis Cartilage 12 (Suppl. B):[ M66], 2004. Yet to be updated
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