Product Information

S2235 BI6727
PLK

Novel Life Science Reagents

for Cell Signaling Research

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Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 618.81 C34H50N8O3 Unknown 99% at -20 2 years 755038-65-4
O N N N N O H N O H N N N

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Tech Support
tech@selleckchem.com
(chemistry support)

Synonyms: Volasertib

techbio@selleckchem.com
(bio support)

Biological Activity
BI 6727 is a highly potent Polo-like kinase inhibitor with an IC50 of 0 .87 nM BI 6727 has an EC50 of 11-37 nM on a panel of cancer cell lines and selective dihydropteridinone with distinct properties. BI 6727 has a pharmacokinetic profile favoring sustained exposure of tumor tissues with a high volume of distribution and a long terminal half-life in mice. BI 6727 has physicochemical and pharmacokinetic properties that allow in vivo testing of i.v. as well as oral formulations, adding flexibility to dosing schedules. BI 6727 shows marked antitumor activity in multiple cancer models, including a model of taxane-resistant colorectal cancer. [1][2][3]

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References
[1] Rudolph D et al. Clin Cancer Res. 2009 May 1; 15(9):3094-102. [2] Schffski P. Oncologist. 2009 Jun; 14(6):559-70. [3] Grinshtein N et al. Cancer Res. 2011 Feb 15; 71(4):1385-95. .

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

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