PUBLICATIONS

Bourgault-Villada I, Hong M, Khoo K, Tham M, Toh B, Wai LE and Abastado JP: Current
insight into the metastatic process and melanoma cell dissemination Melanoma 2011
ISBN 978-953-307-293-7 Editor Mandi Murph Publisher Intech

Nardin N, Wong WC, Tow C, Molina TJ, Tissier F, Audebourg A, Garcette G, Caignard A,
Avril MF, Abastado JP and Prévost-Blondel A: Dacarbazine promotes stromal remodeling
and lymphocyte infiltration in cutaneous melanoma lesions. J. Invest Derm 2011

Lengagne R, Pommier A, Caron J, Douguet L, Garcette M, Kato M, Avril MF, Abastado

JP, Bercovici N, Lucas B, Armelle Prévost-Blondel A: T Cells Contribute to Tumor
Progression by Favoring Pro-Tumoral Properties of Intra-Tumoral Myeloid Cells in a
Mouse Model for Spontaneous Melanoma, PLoS ONE 2011 6: 5, e20235

Lucile Warter, Chia Yin Lee, Rekha Thiagarajan, Marc Grandadam, Serge Lebecque,
Raymond T. P. Lin, Sebastien Bertin-Maghit, Lisa F. P. Ng, Jean-Pierre Abastado,
Philippe Desprès, Cheng-I Wang and Alessandra Nardin. Chikungunya Virus Envelope-
Specific Human Monoclonal Antibodies with Broad Neutralization Potency. J. Immunol

2010

Wong SC, Puaux AL, Chittezhath M, Shalova I, Kajiji TS, Wang X, Abastado JP, Lam KP,
Biswas SK. Macrophage polarization to a unique phenotype driven by B cells. Eur J
Immunol. 2010 May 12.

Eyles J, Puaux AL, Wang XJ, Toh B, Prakash C, Hong M, Tan TG, Zheng L, Ong LC, Jin
Y, Kato M, Prévost-Blondel A, Chow P, Yang H and Abastado JP: Tumor cells
disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model
of melanoma. J. Clin Invest, 2010 Jun 1;120(6):2030-9

Chew V, Tow C, Teo M, Wong HL, Chan J, Gehring A, Loh M, Bolze A, Quek R, Lee VK,
Lee KH, Abastado JP, Toh HC, Nardin A. Hepatocellular carcinoma patient survival is
sustained by activation of innate immunity within the tumor microenvironment.
J.Hepatology. 2010 Mar;52(3):370-9.

PATENT: "Binding Molecules against Chikungunya Virus and uses thereof" European
Patent EP10305353.4 Singapore Patent 343109 IPOS S34 - Lucile Warter, Alessandra
Nardin, Cheng-I Wang and Jean-Pierre Abastado

2008

Nardin A and Abastado JP. Macrophages and Cancer. Frontiers in Biosciences 2008 May
1;13:3494-505

Lengagne R, Graff-Dubois S, Garcette M, Renia L, Kato M, Guillet JG, Engelhard VH, Avril
MF, Abastado JP, Prévost-Blondel A. Distinct Role for CD8 T Cells Toward Cutaneous
Tumors and Visceral Metastases. J. Immunol. 2008 Jan 1;180(1):130-7.

2007

Kosmatopoulos K and Abastado JP. Improving Tumour Immunity. Eur. BioPharmaceutical

Review Summer 2007, 56-58
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Faure O, Graff-Dubois S, Alves PM, Cornet S, Duffour MT, Scardino A, Gross DA,
Miconnet I, Salcedo M, Chouaib S, Lemonnier FA, Abastado JP, Kosmatopoulos K.
Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an
Hsp70 oligoepitope peptide. Oncol Rep. 2007 Mar;17(3):679-85

2006

Ceccaldi PE, Delebecque F, Prevost MC, Moris A, Abastado JP, Gessain A, Schwartz O,
Ozden S. DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus
type 1-infected cells. J Virol. 2006 May;80(10):4771-80.

Nardin A, Lefebvre ML, Labroquère K, Faure O, Abastado JP. Liposomal Muramyl

Tripeptide Phosphatidylethanolamine: Targeting and Activating Macrophages for Adjuvant
Treatment of Osteosarcoma. Curr Cancer Drug Targets. 2006 Mar;6(2):123-33.

Salcedo M, Bercovici N, Taylor R, Vereecken P, Massicard S, Duriau D, Vernel-Pauillac F,

Boyer A, Baron-Bodo V, Mallard E, Bartholeyns J, Goxe B, Latour N, Leroy S, Prigent D,
Martiat P, Sales F, Laporte M, Bruyns C, Romet-Lemonne JL, Abastado JP, Lehmann F,
Velu T. Vaccination of melanoma patients using DC loaded with an allogeneic tumor cell
lysate. Cancer Immunol Immunother. 2006 Jul;55(7):819-29.

2005

Kaiser A, Donnadieu E, Abastado JP, Trautmann A, Nardin A. CCL19 secreted by mature

dendritic cells increases naive T cell scanning behavior and their response to rare cognate
antigen. J Immunol. 2005 Aug 15;175(4):2349-56

Nobile C, Petit C, Moris A, Skrabal K, Abastado JP, Mammano F, Schwartz O. Covert HIV
replication in Dendritic Cells and in DC-SIGN-expressing cells promotes long-term
transmission to lymphocytes. J. Virol. 2005; 79:5386-99

Babon A, Almunia C, Boccaccio C, Beaumelle B, Gelb MH, Menez A, Maillere B,

Abastado JP, Salcedo M, Gillet D. Cross-presentation of a CMV pp65 epitope by human
dendritic cells using bee venom PLA2 as a membrane-binding vector. FEBS Lett. 2005;
579(7):1658-64.

Nardin A. and Abastado JP. Cellular Vaccines: Current Status In “Frontiers in the
development of novels vaccines” Horizon Scientific Press/Caister Scientific Press

2004

Moris A, Nobile C, Buseyne F, Porrot F, Abastado JP, Schwartz O. DC-SIGN promotes

exogenous MHC-I–restricted HIV-1 antigen presentation. Blood 2004; 103: 2648-54

Mallard E, Vernel-Pauillac F, Velu T, Lehmann F, Abastado JP, Salcedo M, Bercovici N.

IL-2 production by virus- and tumor-specific human CD8 T cells is determined by their fine
specificity. J Immunol. 2004; 172: 3963-70

Faure O, Graff-Dubois S, Bretaudeau L, Derre L, Gross DA, Alves PM, Cornet S, Duffour
MT, Chouaib S, Miconnet I, Gregoire M, Jotereau F, Lemonnier FA, Abastado JP,
Kosmatopoulos K. The Inducible Hsp70 as Target of Anticancer Immunotherapy :
Identification of HLA-A*0201-restricted Epitopes 1. Intl J. of Cancer 2004; 108:863-70
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2003

Abastado JP. L’immunotherapie cellulaire : une nouvelle approche contre le cancer. La

Jaune et La rouge (Revue de l’Ecole Polytechnique), Dec 2003

Setterblad N, Roucard C, Boccaccio C, Abastado JP, Charron D, Mooney N. Composition

of MHC class II enriched lipid microdomains is modified during maturation of primary
dendritic cells. J Leukoc Biol. 2003; 74(1):40-8.

Loirat D, Mancini-Bourgine M, Abastado JP, Michel ML. HBsAg/HLA-A2 transgenic mice:

a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus
infection. Int Immunol. 2003; 15(10):1125-36

Abastado JP. L’immunothérapie cellulaire : complexité du système immunitaire et

développement industriel. Bull. du Cancer 2003 ; 90(8-9):789-94.

Bercovici N, Givan A, Waugh G, Fisher L,Vernel-Pauillac F, Ernsoff M, Abastado JP,

Wallace PK. Multiparameter precursor analysis of T-cell responses to antigen. J Immunol
Methods 2003; 276(1-2):5-17

Tailleux L, Neyrolles O, Honoré-Bouakline S, Perret E, Sanchez F, Abastado JP,

Lagrange PH, Gluckman JC, Rosenzwajg M, Herrmann JL. Constrained intracellular
survival of Mycobacterium Tuberculosis in human dendritic cells
J Immunol. 2003 ;170(4):1939-48.

Kaiser A, Bercovici N, Abastado JP, Nardin A. Naive CD8+ T cell recruitment and
proliferation are dependent on stage of dendritic cell maturation. Eur J Immunol.
2003;33(1):162-71.

2002

Rössle SC, Bisch PM, Lone YC, Abastado JP, Kourilsky P, Bellio M. Mutational Analysis
and molecular modeling of the binding of S. aureus Enterotoxin C2 to a murine T Cell
receptor Vß chain. Eur J Immunol. 2002 ; 32(8):2172-8.

Pagès F, Lebel-Binay S, Vieillefond A, Deneux L, Cambillau M, Soubrane O, Debré B,

Tardy D, Lemonne JL, Abastado JP, Fridman WH, Thiounn N. Local Immunostimulation
Induced by Intravesical Administration of Autologous Interferon-Gama-Activated
Macrophages in Patients with Superficial Bladder Cancer. Clin Exp Immunol 2002 ;
127(2):303-9

Boccaccio C, Jacod S, Kaiser A, Boyer A, Abastado JP, Nardin A. Identification of a

clinical-grade maturation factor for dendritic cells. J Immunother 2002 Jan-Feb;25(1):88-96

Arrode G, Boccaccio C, Abastado JP, Davrinche C. Cross presentation of human

cytomégalovirus pp65 (UL83) to CD8+T cells is regulated by virus induced soluble
mediator-dependent maturation of dendritic cells. J. Virol, Jan. 2002, 76 p. 142-150

Sol-Foulon N, Moris A, Nobile C, Boccaccio C, Engering A, Abastado JP, Heard JM, Van
Kooyk Y, Schwartz O. HIV-1 Nef Induced up-regulationof DC-SIGN in Dendritic Cells
Promotes Lymhocyte Clustering and Viral Spread. Immunity, 2002 Vol. 16, 1-20,

2001
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Bédouet L, Bousser MT, Frison N, Boccaccio C, Abastado JP, Marceau P, Mayer R,
Monsigny M, Roche AC. Uptake of dimannoside Clusters and Oligomannosides by Human
Dendritic Cells. Bioscience Reports, Vol. 21, No 6, December 2001

Abastado JP. Dendritic Cells for cancer immunotherapy. Exp. Brain Res. Autumn 2001
p.45-46.

Petit C, Buseyne F, Boccaccio C, Abastado JP, Heard JM, Schwartz O. Nef is required for
efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes. Virology. 2001
Jul 20;286(1):225-36.

Buseyne F, Gall SL, Boccaccio C, Abastado JP, Lifson JD, Arthur LO, Rivière Y, Heard
JM, Schwartz O. MHC-I restricted presentation of HIV-1 virion antigens without viral
replication. Nat Med 2001 Mar ; 7(3) : 344-9

2000

Arrode G, Boccaccio C, Lulé J, Allart S, Moinard N, Abastado JP, Alam A, Davrinche C.

Incoming human cytomegalovirus pp35 (UL83) contained in apoptotic infected fibroblasts
is cross-presented to CD8+ T cells by dendritic cells. J Virol. 2000 Nov; 74(21) : 10018-24

Abastado JP, Boyer A, Salcedo M. Les techniques d'analyse de la réponse immunitaire

Biofutur. 2000. 196, Cahier 118 : 1-9

Goxe B, Latour N, Chokri M, Abastado JP, Salcedo M. Simplifed method to generate large
quantities of dendritic cells suitable for clinical applications. Immunol Invest. 2000
Aug;29(3):319-36.

Rouard H, Léon A, Klonjkowski B, Marquet J, Tennezé L, Plonquet A, Agrawal SG,

Abastado JP, Eloit M, Farcet JP, Delfau-Larue MH. Adenoviral transduction of human
"Clinical Grade" immature dendritic cells enhances costimulatory molecule expression and
T-cell stimulatory capacity. J Immunol Methods. 2000 Jul 31;241(1-2):69-81.

Bercovici N, Duffour MT, Agrawal S, Salcedo M, Abastado JP. New methods for assessing
T cell responses. Clin Diagn Lab immunol. 2000 Jul : 859-64

Minty A and Abastado JP. L'IL-13 et son utilisation dans la manipulation de la réponse
anti-tumorale. Euro Cancer, XXème forum de cancérologie, Paris, France, 6-8 Juin 2000 ; p
119-120µ

Salcedo M, Colucci F, Dyson PJ, Cotterill LA, Lemonnier FA, Kourilsky P, Di Santo JP,
Ljunggren HG, Abastado JP. Role of a Qa-1b- Binding receptors in the specify of
developing NK cells. Eur J Immunol. 2000 Apr;30(4):1094-101.

Batalia MA, Kirksey TJ, Sharma A, Jiang L, Abastado JP, Yan S, Zhao R, Collins EJ.
Class I MHC is stabilized against thermal denaturation by physiological concentrations of
NaCl. Biochemistry. 2000 Aug 1 ;39(30) :9030-8

Calbo S, Guichard G, Muller S, Kourilsky P, Briand JP, Abastado JP. Antitumor

vaccination using a major histocompatibility complex (MHC) class I-restricted
pseudopeptide with reduced peptide bond. J Immunother. 2000 Jan ;23(1) :125-30

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1999

Cambiaggi A, Darche S, Guia A, Kourilsky P, Abastado JP, Vivier E. Modulation of T-cell

functions in KIR2DL3 (DC158b) transgenic mice. Blood. 1999 Oct 1 ;94(7) :2396-402

Rovira P, Buckle M, Abastado JP, Peumans WJ, Truffa-Bachi P. Major histocompatibility

class I molecules present Urtica dioica aglutinin, a superantigen of vegetal origin, to T
lymphocytes. Eur J Immunol. 1999 May ;29(5) :1571-80

Bousso P, Levraud JP, Kourilsky P, Abastado JP. The composition of a primary T cell
response is largely determined by the timing of recrutiment of individual T cell clones. J
Exp Med. 1999 May 17 ;189(10) :1591-600

Calbo S, Guichard G, Bousso P, Muller S, Kourilsky P, Briand JP, Abastado JP. Role of
peptide backbone T cell recognition. J Immunol. 1999 Apr 15 ;162(8) :4657-62

Abastado JP. Analyse de la réponse immunitaire lymphocytaire T. Immunodermatologie

Séminaire 1999, p 99-108

1998

Calbo S, Bousso P, Guichard G, Abastado JP. The mouse T-cell response against the
HLCA-cw3 peptide and related pseudo peptide Proceeding of the 10 th international
meeting of immunology (1998 – p 267 à 272)

Abastado JP. Analyse de la réponse immunitaire lymphocytaire T. Immunodermatologie

Séminaire J.F.Nicolas, J.Thivolet, eds. John Libbey, Eurotext, Paris, 1998 p.1-1

Lone YC, Motta I, Mottez E, Guilloux Y, Lim A, Demay F, Levraud JP, Kourilsky P,
Abastado JP. In vitro induction of specific cytotoxic T lymphocytes using recombinant
single-chain MHC class I/peptide complexes. J Immunother. 1998 Jul ;21(4) :283-94

Matsumoto N, Ribaudo RK, Abastado JP, Margulies DH, Yokoyama WM. The lectin-like
NK cell receptor Ly-49A recognizes a carbohydrate-independent epitope on its MHC class
I ligand. Immunity. 1998 Feb ;8(2) : 245-54

Mahiou J, Abastado JP, Cabanie L, Godeau F. Soluble FasR ligand-binding domain :

high-yield production of active fusion and non-fusion recombinant proteins using the
baculovirus/insect cell system. Biochem J. 1998 Mar 1 ;330(Pt2) :1051-8

Noun G, Reboul M, Abastado JP, Kourilsky P, Signaux F, Pla M. Strong alloantigenicity of

the alpha-helices residues of the MHC class I molecule. J Immunol. 1998 Jul
1 ;161(1) :148-53

Pardigon N, Bercovici N, Calbo S, Santos-Lima EC, Liblau R, Kourilsky P, Abastado JP.

Role of co-stimulation in CD8+ T cell activation. Int Immunol. 1998 May ;10(5) :619-30

Bousso P, Casrouge A, Altman JD, Haury M, Kanellopoulos J, Abastado JP, Kourilsky P.

Individual variations in the murine T cell response to a specific peptide reflect variability in
naive repertoires. Immunity. 1998 aug ;9(2) :169-78

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Salcedo M, Bousso P, Ljunggren HG, Kourilsky P, Abastado JP. The Qa-1b molecule
binds to a large subpopulation of murine NK cells. Eur J Immunol. 1998
Dec ;28(12) :4356-61

Delon J, Grégoire B, Malissen S, Darche F, Lemaitre P, Kourilsky P, Abastado JP,

Trautmann A. CD8 expression allows T cell signaling by monomeric peptide-MHC
complexes. Immunity. 1998 Oct ;9(4) :467-73

Abastado JP, Bousso P, Casrouge A, Harada H, Calbo S, Kanellopoulos J, Kourilsky P.

Potentiels et limites des techniques autorisant le suivi d’une réponse T. Club SFI (1998) p
78-81

1997

Bousso P, Michel F, Pardigon N, Bercovici N, Libla R, Kourilsky P, Abastado JP.

Enrichment of antigen-specific T lymphocytes by panning on immobilized MHC-peptide
complexes. Immunol Lett. 1997 Nov ;59(2) :85-91

1996

Wei WZ, Gill RF, Jones RF, Lichlyter D, Abastado JP. Induction of cytotoxic T
lymphocytes to murine mammary tumor cells with a Kd-restricted imunogenic peptide. Int J
Cancer. 1996 May 29 ;66(5) :659-63

Quesnel A, Hsu SC, Delmas A, Steward MW, Trudelle Y, Abastado JP. Efficient binding to
the MHC class I K(d) molecule of synthetic peptides in which the anchoring position 2
does not fit the consensus motif. FEBS Lett. 1996 May 27 ;387(1) :42-6

Noun G, Reboul M, Abastado JP, Jaulin C, Kourilsky P, Pla M. Alloreactive monoclonal

antibodies select Kd molecules with different peptide profiles. J. Immunol. 1996 Sep
15 ;157(6) :2455-61

Abastado JP. Apoptosis : function and regulation of cell death. Res Immunol. 1996
Sep ;147(7) :446-56. Review

Reboul M, Noun G, Lacabanne V, Abastado JP, Kourilsky P, Pla M. Importance of single

amino acid substitution of the alpha helices of class I MHC molecule for the induction of a
primary allogeneic response. Allorecognition, tolerance and immunosupression in
transplantation. (1996)

1995

Mottez E, Langlade-Demoyen P, Gournier H, Martinon F, Maryanski J, Kourilsky P,

Abastado JP. Cells expressiong a major histocompatibility complex class I molecule with a
single covalently bound peptide are highly immunogenic. J Exp Med. 1995 Feb
1 ;181(2) :493-502

Abastado JP, Lone YC, Casrouge A, Boulot G, Kourilsky P. Dimerization of soluble major
histocompatibility complex-peptide complexes is sufficient for activation of T cell
hybridoma and induction of unresponsiveness. J Exp Med. 1995 Aug 1 ;182(2) :439-47

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Guichard G, Calbo S, Muller S, Kourilsky P, Briand JP and Abastado JP. Efficient binding
of reduced peptide bond pseudopeptides to major histocompatibility complex class I
molecule. J Biol Chem. 1995 Nov 3 ;270(44) :26057-9

Quesnel A, Casrouge A, Delmas A, Kourilsky P, Abastado JP, Trudelle Y. Use of synthetic

peptide libraries for the H-2Kd binding motif identification. Pept Res. 1995 Jan-
Feb ;8(1) :44-51

Kourilsky P, Abastado JP, Cabaniols JP, Demay F, Even J, Kanellopoulos J, Langlade-

Demoyen P, Levraud JP, Pannetier C, Roth C. Anti-tumoral T response. Stimulation and
analysis. Colloque de l'année Pasteur : les vaccins, un siècle après Louis Pasteur, p 155-
159, Paris (1995)

1994

Bellio M, Lone YC, De la Calle-Martin O, Malissen B, Abastado JP, Kourilsky P. The V

beta complementarity determining region 1 of a major histocompatibility complex (MHC)
class I-restricted T cell receptor is involved in the recognition of peptide/MHC I and
superantigen/MHC II complex. J Exp Med.1994Apr1 ;179(4) :1087-97

Lone YC, Ojcius DM, Bellio M, Kourilsky P, Abastado JP. Major contribution of the beta
chain to the antigen specificity of a T cell receptor. C R Acad Sci III. 1994 Jul ;317(7) :645-
51

Feuerbach D, Etteldorf S, Ebenau-Jehle C, Abastado JP, Madden D, Burgert HG.

Identification of amino acids within the MHC+ molecule important for the interaction with
the adenovirus protein E3/19K. J Immunol. 1994 Aug 15 ;153(4) :1626-36

Gill RF, Abastado JP, Wei WZ. Systematic identification of H-2 Kd binding peptides and
induction of peptide specific CTL. J Immunol Methods. 1994 Dec 2 ;176(2) :245-53

Lone YC, Bellio M, Prochnicka-Chalufour A, Ojcius D, Boissel N, Ottenhoff THM,

Klausner R, Abastado JP, Kourilsky P. Role of the CFR1 region of the TCR beta chain in
the binding to purified MHC-peptide complex. Int Immunol. 1994 Oct ;6(10) :1561-5

Langlade-Demoyen P, Levraud JP, Kourilsky P, Abastado JP. Primary cytotoxic T

lymphocyte induction using peptide-stripped autologous cells. Int Immunol. 1994
Nov ;6(11) :1759-66

Abastado JP. Structure Génétique du Complexe Majeur d'Histocompatibilité. Cours de la

SFI (1994)

Abastado JP, Mottez E, Casrouge A, Kourilsky P, Langlade-Demoyen P. Induction de CTL

et vaccination à l'aide de cellules exprimant une densité élevée de peptide antigénique.
L'immuno-intervention: de la biothérapie à la thérapie génique. (S. Chouaib et J.-M.
Mencia-Huerta, ed.) p305-316 (1994)

1993

Ojcius DM, Abastado JP, Godeau JF, Kourilsky P. Binding of alanine-substituted peptides
to the MHC class I proteins, Kd. FEBS Lett. 1993 Feb 8 ;317(1-2) :49-52

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Ojcius DM, Godeau F, Abastado JP, Casanova JL, Kourilsky P. Real-time measurement
of antigenic peptide binding to empty and preloaded single-chain major histocompatibility
complex class I molecules. Eur J Immunol. 1993 May ;23(5) :1118-24

Abastado JP, Ojcius DM, Casrouge A, Yeh P, Schumacher T, Ploegh H, Kourilsky P. A

soluble, single-chain Kd molecules produced by yeast selects a peptide repertoire
indistinguishable from that of cell-surface-associated Kd. Eur J Immunol. 1993
Aug ;23(8) :1776-83

Abastado JP, Casrouge A, Kourilsky P. Differential role of conserved and polymorphic

residues of the binding groove of MHC class I molecules in the selection of peptides. J
Immunol. 1993 Oct 1 ;151(7) :3569-75

Ojcius DM, Abastado JP, Carouge A, Mottez E, Cabanié L, Kourilsky P. Dissociation of the
peptide-MHC class I complex limits the binding ratee of exogenous peptide. J Immunol.
1993 Dec 1 ;151(11) :6020-6

Abastado JP and Kourilsky P. La présentation de l'antigène.in Traité d'Immunologie (J.-F.

Bach, ed.) Médecine-Sciences, Flammarion, p 505-522 (1993).

Abastado JP. Le complexe majeur d'histocompatibilité : recombinaisons, pressions

sélectives et évolution. Médecine/Sciences, 9 pp I-IX, (1993)

1992

Ojcius DM, Abastado JP, Godeau F, Kourilsky P. Peptide binding to MHC class I proteins
measured with a novel fluorescent technique. C R Acad Sci III. 1992;315(9) :337-41

1991

Abastado JP, Miller PF, Jackson BM, Hinnebusch AG. Suppression of ribosomal
reinitiation at upstream open reading frames in amino acid-starved cells forms the basis
for CGN4 translational control. Mol Cell Biol. 1991 jan;11(1) :486-96

Abastado JP, Miller PF, Hinnebusch AG. A quantitative model for translational control of
the GCN4 gene of Saccharomyces cerevisiae. New Biol. 1991 May ;3(5) :511-24

1990

Abastado JP. and Kourilsky P. Introduction to the major histocompatibility complex. In The
Immunology of the Fetus. (G. Chaouat, Ed.) CRC Press, Inc. (1990).

Abastado JP and Kourilsky P. Gene conversion and the generation of polymorphism in the
class I genes of the mouse major histocompatibility complex. in Molecular biology of HLA
class II antigens (J. Silver, ed.) CRC Press, Inc. 186-200, (1990)

1989

Maryanski JL, Abastado JP, MacDonald HR, Kourilsky P. Intradomain H-2Kd/Dd

recombinants define the same regions as crucial for recognition by alloreactive or major
histocompatibility complex-restricted cytolytic T cells. Eur J Immunol. 1989
Jan ;19(1) :193-6

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Maryanski JL, Abastado JP, Corradin G, Gerottini JC. Structural features of peptides
recognized by H-2Kd-restricted T cells. Cold Spring Harb Symp Quant Biol. 1989 ;54 Pt
1 :545-50

Abastado JP, Darche S, Jouin H, Delarbre C, Gachelin G, Kourilsky P. A monoclonal

antibody recognizes a subset of the H-2Dd mouse major class I antigens. Res Immunol.
1989 Jun-Aug ;140(5-6) :581-94

Martinon F, Cornille F, Gomard E, Fournié-Zaluski MC, Abastado JP, Roques BP, Lévy
JP. Two epitopes and one agretope map to a single HLA-A2 peptide recognized by H-2-
restricted T cells. J Immunol. 1989 May 15 ;142(10) :3489-94

1988

Abastado JP. Les antigènes d'histocompatibilité ou les avantages de la diversité. La Jaune

et la Rouge, Janvier 1988.

Abastado JP, Maryanski J, Jaulin C, Kourilsky P. Analysis of specificities recognized by

monoclonal antibodies and cytotoxic T lymphocytes using chimeric H-2 molecules. In:
MHC+X, Complex formation and antibody induction (P. Ivanyi, Ed.) Springer Verlag Berlin-
Heidelberg, 186-192, 1988.

Abastado JP. Les molécules HLA prennent du relief. La Recherche. Mars 1988

1987

Plata F, Langlade-Demoyen P, Abastado JP, Berbar T, Kourilsky P. Molecular analysis of

the T lymphocyte response elicited by retrovirus induced tumors in mice. In: "Vaccines 87"
Cold Spring Harbor Laboratory.

Plata F, Langlade-Demoyen P, Abastado JP, Berbar T, Kourilsky P. Retrovirus antigens

recognized by ctolytic T lymphocytes activate tumor rejection in vivo. Cell. 1987 Jan
30 ;48(2) :231-40

Abastado JP, Darche S, Godeau F, Cami B, Kourilsky P. Intramolecular recombination

between partially homologous sequences in Escherichia coli and Xenopus laevis oocytes.
Proc Natl Acad Sci U S A. 1987 Sep ;84(18) :6496-500

Abastado JP, Jaulin C, Schutze MP, Langlade-Demoyen P, Plata F, Ozato K, Kourilsky P.

Fine mapping of epitopes by intradomain Kd/Dd recombinants. J Exp Med. 1987 Aug
1 ;166(2) :327-40

Maryanski J, Abastado JP, Kourilsky P. Specificity of peptide presentation by a set of

hybrid mous class I MHC molecules. Nature. 1987 Dec 17-23 ;330(6149) :660-2

1986

Plata F, Langlade-Demoyen P, Abastado JP, Berbar T, Kourilsky P. Molecular definition of

retrovirus-induced antigens recognized by tumour-specific H-2-restricted cytolytic T
lymphocytes. J Immunogenet. 1986 Apr-Jun ;13(2-3) :263-8

Plata F, Langlade-Demoyen P, Abastado JP, Berbar T, Kourilsky P. Molecular analysis of

he cytolytic T-lymphoncyte response elicited by retrovirus-induced tumours in mice. Ann
Inst Pasteur Immunol. 1986 Nov-Dec ;137D(3) :409-12
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1985

Abastado JP, Plata F, Morello D, Daniel-Vedele F, Kourilsky P. H-2 restricted cytolysis of L

cllls doubly transformed with a cloned H-2Kb gene and cloned retroviral DNA. J Immunol.
1985 Nov ;135(5) :3512-9

Jaulin C, Perrin A, Abastado JP, Dumas B, Papamatheakis J, Kourilsky P. Polymorphism

in mouse and human class I H-2 and HLA genes is not the result of random independent
point mutations. Immunogenetics. 1985 ;22(5) :453-70

1984

Abastado JP, Cami B, Dinh TH, Igolen J, Kourilsky P. Processing of complex

heteroduplexes in Escherichia coli and Cos-1 monkey cells. Proc Natl Acad Sci U S A.
1984 Sep ;81(18) :5792-6

1982

Lalanne JL, Delarbre C, Brégégère F, Abastado JP, Gachelin G, Kourilsky P. Comparison

of nucleotide sequencs of mRNAs belonging to the mouse H-2 multigene family. Nucleic
Acids Res. 1982 Feb 11 ;10(3) :1039-49

Abastado JP, Dumas B, Lalanne JL, Daniel F, Morello D, Papamatheakis J, Cayre Y,

Cami B, Gachlin G, Kourilsky P. Cloning and analysis of mouse genes coding for H-2
transplantation antigens. Proceedings of the Annual Meeting of the Japapnese Medical
Research Foundation – Osaka, Japan, Janvier 1982, pp. 37-50

Gachelin G, Dumas B, Abastado JP, Cami B, Papamatheakis J, Kourilsky P. Mouse

genes coding for the major class I transplantation antigens: a mosaic structure might be
related to the antigenic polymorphism. Ann Immunol (Paris). 1982 Jan-Feb ;133C(1) :3-20.
Review

1981

Brégégère F, Abastado JP, Kvist S, Rask L, Lalanne JL, Garoff H, Cami B, Wiman K,
Larhammar D, Peterson PA, Gachelin G, Kourilsky P, Dobberstein B. Structure of C-
terminal half of two H-2 antigens from cloned mRNA. Nature. 1981 Jul 2 ;292(5818) :78-81

Cami B, Brégégère F, Abastado JP, Kourilsky P. Multiple sequences related to classical

histocompatibility antigens in the mouse genome. Nature. 1981 Jun 25 ;291(5817) :673-5

Kvist S, Brégégère F, Rask L, Cami B, Garoff H, Daniel F, Wiman K, Larhammar D,

Abastado JP, Gachelin G, Peterson PA, Dobberstein B, Kourilsky P. cDNA clone coding
for part of a mouse H-2d major histocompatibility antigen. Proc Natl Acac Sci U S A. 1981
May ;78(5) :2772-6

Baldacci P, Royal A, Brégégère F, Abastado JP, Cami B, Daniel F, Kourilsky P. DNA

organisation in the chicken lysozyme gene region. Nucleic Acids Res. 1981 Aug
11 ;9(5) :3575-88

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Patent List

1991 - 2009

"An alterated major histocompatibilité complex (MHC) determinant and methods of using
the determinant" Brevet n° 792,473
Dépôt US (1991) – Mottez E., Abastado J.-P. and Kourilsky P.

"Additional expérimental data showing that the "altered" MHC déterminants of this
invention are functional molécules capable of activating the immune system and
presenting antigens to elicit an antigénique response.
Complément à la déclaration d'inventions N°91-23 (1993) – Lone Y.-C., Casrouge A.
Mottez E., Abastado J.-P. and Kourilsky P.

"Méthode pour générer une population de cellules présentant à leur surface une forte
densité de peptide exogène spécifique associé aux molécules du CMH; population de
cellules".
Brevet n° 94.08427 D.I. n° 94-17 – Langlade-Demoyen P., Abastado J.-P. and Kourilsky
P.

"Methods of using MHC/peptide complexes to obtain or purify antigen-specific T-cells and

to stimulate T-cells
United States patent application (1996) - Langlade-Demoyen P., Lone Y.-C., Kourilsky P.,
Abastado J.-P.

"New lymphocytes, a process for preparing the same and their use, in thermalismes"
Brevet n° 9912084.3-2105.
Dépôt Européen (15/10/1999) - Abastado J.-P. Bartholeyns J.

"LIPO", "Method for enhancing the presentation of exogenous antigen by human APC
and osponized microparticle complex for applying this method".
Dépôt Européen (2000) - Nardin A., Abastado J.-P.

"ZEDR", Ancillary composition for the preparation of committed mature DC's".

Dépôt Européen (2001) - Boccaccio C., Nardin A., Abastado J.-P.

"Composition for the preparation of committed mature dendritic cells"

(Brevet n° 01400109.3-2118).
Dépôt Européen (15/01/2001) - Boccaccio C., Nardin A., Abastado J.-P.

"MATU" New isolated DC's, process for preparing the same and their use in
pharmaceutical compositions"(Brevet n°01402010.1-2118).
Dépôt Européen (25/07/2001) - Kaiser A, Boccaccio C, Nardin A, Jacod S, Abastado J.-
P.

Method to measure A T cell response and its uses to qualify antigen-presenting cells
Dépôt Européen (02/12/03) Brevet n° 03780101.6-2404-EP0313579

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"Binding Molecules against Chikungunya Virus and uses thereof" European Patent
EP10305353.4 Singapore Patent 343109 IPOS S34 - Lucile Warter, Alessandra Nardin,
Cheng-I Wang and Jean-Pierre Abastado

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