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CARCINOG ENS

HPV

ESTROGEN

Transformation zone (squamocolumnar junction) Cervical dysplasia (cervical intraepithelial neoplasia) Carcinoma in situ

Invasive cancer

EXOPHYTIC

NODULAR

INFILTRATIVE

ULCERATIVE

Formation of large, friable, bulky mass Tumors involving the superficial aspect of cervix Pressure to the cervix (thru vagina) Breaks in blood vessels Compresses the nerve endings

Grows into confluent, firm masses Cervix and isthmus expand

exocervica l Invades the vaginal fornices and upper part of vagina VAGINAL BLEEDIN G METRORRH AGIA

endocervica Invades corpus and parametrium Hormonal imbalance

Tumor necrosis and sloughing

Complicated by infection

BARRELSHAPED CERVIX

SEROPURUL ENT DISCHARGE

MENORRH AGIA

VAGINAL BLEEDING

DYSPAREU NIA

PATHOPHYSIOLOG Y OF CERVICAL CANCER

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