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and eventual gangrene of the bowel wall. Broadly, AMI may be classified either as arterial or venous disease. Arterial disease may be subdivided into nonocclusive mesenteric ischemia (NOMI; see the image below) and occlusive mesenteric arterial ischemia (OMAI). OMAI may be further subdivided into acute mesenteric arterial embolus (AMAE) and acute mesenteric arterial thrombosis (AMAT). Venous disease takes the form of mesenteric venous thrombosis (MVT). Thus, for practical purposes, AMI comprises 4 different primary clinical entities: NOMI, AMAE, AMAT, and MVT.
superior mesenteric vein (SMV), which joins the splenic vein to form the portal vein. AMI arises primarily from problems in the SMA circulation or its venous outflow. Collateral circulation from the CA and IMA may allow sufficient perfusion if flow in the SMA is reduced because of occlusion, a low-flow state (eg, NOMI), or venous occlusion. The IMA seldom is the site of lodgment of an embolus. Because of its smaller lumen, only small emboli can enter this vessel. When lodgment occurs, the embolus lodges at the site where the IMA divides into the left colic, sigmoidal, and superior hemorrhoidal arteries. In such instances, collateral flow from the middle colic and middle hemorrhoidal arteries (through the vascular arcades of the IMA distal to the embolus) may sustain the perfusion of the left colon.
History
To some extent, all types of acute mesenteric ischemia (AMI) present similarly. Differences in clinical appearance for each type are discussed below. The most important finding is pain that is disproportionate to physical examination findings. Typically, pain is moderate to severe, diffuse, nonlocalized, constant, and sometimes colicky. Onset varies from type to type. Nausea and vomiting are found in 75% of affected patients. Anorexia and diarrhea progressing to obstipation are also common. Abdominal distention and gastrointestinal (GI) bleeding are the primary symptoms in as many as 25% of patients. Pain may be unresponsive to narcotics. As the bowel becomes gangrenous, rectal bleeding and signs of sepsis (eg, tachycardia, tachypnea, hypotension, fever, altered mental status) develop. A review of systems, looking for risk factors of AMI, should be performed. This syndrome has a catastrophic outcome if not properly and rapidly treated. It should be considered in any patient with abdominal pain disproportionate to physical findings, gut emptying in the form of vomiting or diarrhea, and the presence of risk factors, especially age older than 50 years.
CT scan (with contrast) of nonocclusive mesenteric ischemia with resulting bowel wall edema (arrows).
The 4 types of AMI have somewhat different predisposing factors, clinical pictures, and prognoses. A secondary clinical entity of mesenteric ischemia occurs because of mechanical obstruction, such as internal hernia with strangulation, volvulus, intussusception, tumor compression, and aortic dissection. Occasionally, blunt trauma may cause isolated dissection of the superior mesenteric artery (SMA) and lead to intestinal infarction. Because the 4 types of AMI share many similarities and a final common pathway (ie, bowel infarction and death, if not properly treated), they are discussed together. In 1930, Cokkinis remarked, Occlusion of the mesenteric vessels is apt to be regarded as one of those conditions of which the diagnosis is impossible, the prognosis hopeless, and the treatment almost useless.[1] This quote indicates some of the extreme difficulties faced by physicians treating AMI. Symptoms are nonspecific initially, before evidence of peritonitis presents. Thus, diagnosis and treatment are often delayed until the disease is advanced. Fortunately, since 1930, many advances have been made that allow earlier diagnosis and treatment. Whereas the prognosis remains grave for patients in whom the diagnosis is delayed until bowel infarction has already occurred, patients who receive the appropriate treatment in a timely manner are much more likely to recover.[2] Typically, the celiac artery (CA) supplies the foregut, hepatobiliary system, and spleen; the SMA supplies the midgut (ie, small intestine and proximal mid colon); and the inferior mesenteric artery (IMA) supplies the hindgut (ie, distal colon and rectum).[3] However, multiple anatomic variants are observed. Venous drainage is through the
a prolonged period with gradual worsening. The chronic form may manifest as esophageal variceal bleeding. Many patients have a history of 1 or more of risk factors for hypercoagulability. These include oral contraceptive use, congenital hypercoagulable states, deep vein thrombosis (DVT), liver disease, tumor, and portocaval surgery.
Diagnostic Considerations
Because acute mesenteric ischemia (AMI) is a condition with an unclear initial presentation, serious morbidity, and a high mortality rate without proper treatment, clinical suspicion should remain high. Obtain early angiography if any suspicion of AMI exists. Subsequent treatment should be initiated as rapidly as possible. No patient in whom AMI is suspected should be discharged unless AMI can be ruled out. Consider a diagnosis of AMI in all elderly patients with abdominal pain, especially if the pain is disproportionate to physical examination findings. Patients with atrial fibrillation, cardiovascular disease, or peripheral vascular disease, especially those with recent myocardial infarction, are at higher risk. Other conditions to consider include the following: Ovarian torsion Small bowel obstruction Volvulus of midgut Splenic vein thrombosis
Pathophysiology
Insufficient perfusion of the small bowel and colon may result from arterial occlusion by embolus or thrombosis (AMAE or AMAT), thrombosis of the venous system (MVT), or nonocclusive processes such as vasospasm or low cardiac output (NOMI). Embolic phenomena account for approximately 50% of all clinical cases, arterial thrombosis for about 25%, NOMI for roughly 20%, and MVT for less than 10%. Rarely, isolated spontaneous dissections of the SMA have been reported.[4, 5, 6, 7] Hemorrhagic infarction leading to perforation is the common pathologic pathway whether the occlusion is arterial or venous. Injury severity is inversely proportional to the mesenteric blood flow and is influenced by the number of vessels involved, systemic mean blood pressure, duration of ischemia, and collateral circulation. The superior mesenteric vessels are involved more frequently than the inferior mesenteric vessels, with blockage of the latter often being silent because of better collateral circulation. Damage to the affected bowel portion may range from reversible ischemia to transmural infarction with necrosis and perforation. The injury is complicated by reactive vasospasm in the SMA region after the initial occlusion. Arterial insufficiency causes tissue hypoxia, leading to initial bowel wall spasm. This leads to gut emptying by
vomiting or diarrhea. Mucosal sloughing may cause bleeding into the gastrointestinal (GI) tract. At this stage, little abdominal tenderness is present, producing the classic intense visceral pain that is disproportionate to physical examination findings. As the ischemia persists, the mucosal barrier becomes disrupted, and bacteria, toxins, and vasoactive substances are released into the systemic circulation. This can cause death from septic shock, cardiac failure, or multisystem organ failure before bowel necrosis actually occurs. As hypoxic damage worsens, the bowel wall becomes edematous and cyanotic. Fluid is released into the peritoneal cavity; this explains the serosanguineous fluid sometimes recovered by diagnostic peritoneal lavage. Bowel necrosis can occur in 8-12 hours from the onset of symptoms. Transmural necrosis leads to peritoneal signs and heralds a much worse prognosis. Embolic AMI (AMAE) is usually caused by an embolus of cardiac origin. Typical causes include mural thrombi after myocardial infarction, atrial thrombi associated with mitral stenosis and atrial fibrillation, vegetative endocarditis, mycotic aneurysm, and thrombi formed at the site of atheromatous plaques within the aorta or at the sites of vascular aortic prosthetic grafts interposed anywhere between the heart and the origin of the SMA. The vascular occlusion is sudden, so the patients have not developed a compensatory increase in collateral flow. As a result, they experience worse ischemia than patients with thrombotic AMI. The SMA is the visceral vessel most susceptible to emboli because of its small take-off angle from the aorta and higher flow. Most often, emboli lodge about 6-8 cm beyond the arterial origin, at a narrowing near the emergence of the middle colic artery. According to the US Centers for Disease Control and Prevention (CDC) Injury Center, a special form of mesenteric ischemia may result from systemic air embolism in those who sustain high-energy blast injuries. These patients sustain severe primary blast injury to the lung, a condition referred to as blast lung. Thrombotic AMI (AMAT) is a late complication of preexisting visceral atherosclerosis. Symptoms do not develop until 2 of the 3 arteries (usually the celiac and superior mesenteric arteries) are stenosed or completely blocked. Progressive worsening of the atherosclerotic stenosis before the acute occlusion allows time for development of additional collateral circulation. Most patients with thrombotic AMI have atherosclerotic disease at other sites, such as coronary artery disease, stroke, or peripheral arterial disease. A drop in cardiac output from myocardial infarction or congestive heart failure (CHF) may cause AMI in a patient with visceral atherosclerosis. Thrombotic AMI may also be a complication of arterial aneurysm or other vascular pathologies, such as dissection, trauma, and thromboangiitis obliterans. In
inflammatory vascular disease, smaller vessels are affected. Thrombosis tends to occur at the origin of the SMA, causing widespread infarction. These patients frequently present with a history of chronic mesenteric ischemia in the form of intestinal angina before the emergent event. NOMI is precipitated by a severe reduction in mesenteric perfusion, with secondary arterial spasm from such causes as cardiac failure, septic shock, hypovolemia, or the use of potent vasopressors in patients in critical condition. Because bowel perfusion, similar to cerebral perfusion, is preserved in the setting of hypotension, NOMI represents a failure of autoregulation. Many vasoactive drugs (eg, digitalis, cocaine, diuretics, and vasopressin) may also cause regional vasoconstriction. Gross pathologic arterial or venous occlusions are not observed. MVT often (ie, >80% of the time) is the result of some processes that make the patient more likely to form a clot in the mesenteric circulation (ie, secondary MVT). Primary MVT occurs in the absence of any identifiable predisposing factor. MVT may also occur after ligation of the splenic vein for a splenectomy or ligation of the portal vein or the superior mesenteric vein as part of damage control surgery for severe penetrating abdominal injuries. Other associated causes include pancreatitis, sickle cell disease, and hypercoagulability caused by malignancy. MVT often affects a much younger population. Symptoms may be present longer than in the typical cases of AMI, sometimes exceeding 30 days. Infarction from MVT is rarely observed with isolated SMV thrombosis, unless collateral flow in the peripheral arcades or vasa recta is compromised as well. Fluid sequestration and bowel wall edema are more pronounced than in arterial occlusion. The colon is usually spared because of better collateral circulation. The chronic form of SMV thrombosis may manifest as esophageal variceal bleeding.
Etiology
Causes of embolic AMI (AMAE) include the following: Cardiac emboli - Mural thrombus after myocardial infarction, auricular thrombus associated with mitral stenosis and atrial fibrillation, septic emboli from valvular endocarditis (less frequent) Emboli from fragments of proximal aortic thrombus due to a ruptured atheromatous plaque Atheromatous plaque dislodged by arterial catheterization Causes of thrombotic AMI (AMAT) include the following: Atherosclerotic vascular disease (most common) Aortic aneurysm Aortic dissection Arteritis Decreased cardiac output from myocardial infarction or CHF (thrombotic AMI may cause acute decompensation) Dehydration from other causes Causes of NOMI include the following:
Hypotension from CHF, myocardial infarction, sepsis, aortic insufficiency, severe liver or renal disease, or recent major cardiac or abdominal surgery Vasopressive drugs Ergotamines Cocaine Digitalis (whether digitalis use causes NOMI or patients who develop NOMI are older and are more likely to have been prescribed digitalis is unclear) Causes of MVT include the following (>80% of patients with MVT are found to have predisposing conditions): Hypercoagulability from protein C and S deficiency, antithrombin III deficiency, dysfibrinogenemia, abnormal plasminogen, polycythemia vera (most common), thrombocytosis, sickle cell disease, factor V Leiden mutation, pregnancy, and oral contraceptive use Tumor causing venous compression or hypercoagulability (paraneoplastic syndrome) Infection, usually intra-abdominal (eg, appendicitis, diverticulitis, or abscess) Venous congestion from cirrhosis (portal hypertension) Venous trauma from accidents or surgery, especially portocaval surgery Increased intra-abdominal pressure from pneumoperitoneum during laparoscopic surgery[8] Pancreatitis Decompression sickness
Prognosis
The prognosis of AMI of any type is grave. Overall, the mortality rate in the last 15 years from all causes of AMI averages 71%, with a range of 59-93%. Once bowel wall infarction has occurred, the mortality rate is as high as 90%. Even with good treatment, up to 50-80% of patients die. Survivors of extensive bowel resection face significant long-term morbidity because of the reduced intestinal mucosal surface available for absorption. However, with rapid treatment, the mortality rate can be reduced considerably, and patients may be spared bowel resection. In a report from Madrid of 21 patients with SMA embolus with little delay in initiating maximal treatment, intestinal viability was achieved in 100% of patients if the duration of symptoms was shorter than 12 hours, 56% if it was 12-24 hours, and only 18% if it was longer than 24 hours. Early recognition and treatment of NOMI has been shown to reduce the mortality rate to 50-55%. Symptomatic MVT has a 30-day mortality rate of 13-15%. A long-term follow-up study of 31 patients who had surgery and survived the acute episode, revealed 2- and 5-year survival rates of 70% and 50%. Deaths were mainly related to cardiovascular comorbidity and malignant disease. With appropriate anticoagulation, only 1 patient died after a recurrent attack of arterial mesenteric thrombosis.
Epidemiology
United States statistics
The overall prevalence of AMI is 0.1% of all hospital admissions; this figure may be expected to rise as the population ages. The exact prevalence of MVT is unknown because many cases are presumed to be limited in symptomatology and to resolve spontaneously. In 1989, the incidence of diagnosed MVT was reported to be 2 cases per 100,000 admissions over 20 years at the Albert Einstein College of Medicine Montefiore Medical Center.
International statistics
Outside of the United States, reported rates of AMI are probably lower in countries with limited diagnostic capability or whose populations have a shorter life expectancy because AMI is primarily a disease of older individuals.
Patient Education
Educate patients who survive to discharge about shortbowel syndrome. Educate surviving patients about the importance of taking warfarin or other discharge medications to prevent recurrence. For patient education resources, see the Environmental Exposures and Injuries Center, as well as The Bends Decompression Syndromes.
Approach Considerations
Recognition of acute mesenteric ischemia (AMI) before permanent tissue damage occurs is the best way to improve patient survival, and only angiography or exploratory surgery makes early diagnosis possible. Experience with computed tomography (CT) and magnetic resonance angiography (MRA) is rapidly changing the
therapeutic approach, allowing prompt laparotomy in patients with suspected AMI when expeditious formal angiography is not available. A second-look procedure is indicated whenever bowel of questionable viability is not resected. After initial medical or surgical stabilization, patients with AMI typically have a prolonged inpatient recovery time. This is especially true when resection of necrotic bowel is performed. Such patients may need to be kept on nil per os (NPO) status, and they may be maintained on parenteral nutrition for some time. If sepsis is evident, liver abscess should be actively sought. During the inpatient stay, every effort must be made to find and, if possible, treat any predisposing cause(s) of AMI. Inpatient medications include the following: Papaverine - For patients with arterial occlusive AMI or nonocclusive mesenteric ischemia (NOMI) Heparin - For patients who have mesenteric venous thrombosis (MVT) or have undergone revascularization Warfarin - For long-term treatment of patients with MVT or atrial fibrillation Broad-spectrum antibiotics and pain medications For all patients Thrombolytics - For selected patients with embolic AMI Because timing is essential in preventing bowel necrosis with its attendant severe morbidity and mortality, patients should be transferred only if the primary hospital lacks adequate services to diagnose and treat the patient. Patients should be optimally resuscitated before transfer. Appropriate services should be available at the receiving hospital. Some experience with percutaneous endovascular interventions has been accumulated. In select cases, especially in isolated spontaneous dissection of the SMA, stent placement may offer the best option.[11]
Heparin anticoagulation
Heparin anticoagulation is the main treatment of MVT. If no signs of bowel necrosis exist, the patient may not even need an operation. Heparin may increase the chance of bleeding complications. A possible avenue of study for future clinical trials is the use of enoxaparin or other lowmolecular-weight heparins as a potential substitute for heparin in the treatment of MVT. Administer heparin as a bolus of 80 U/kg, not to exceed 5000 U, and then as an infusion at 18 U/kg/h until full conversion to oral warfarin. Appropriate monitoring of anticoagulation using activated partial thromboplastin time (aPTT) is mandatory.
Initial Treatment
Resuscitation
Every effort should be made to improve patients cardiovascular status. Vasopressors should be avoided, because they worsen ischemia. Oxygen should be provided to maintain a saturation between 96-99%, by endotracheal intubation if needed. Fluid resuscitation is accomplished with isotonic sodium chloride solution, and blood products are provided as needed. Adequacy of resuscitation can be monitored by urinary output, central venous pressure, or Swan-Ganz pressure monitoring. Insert a nasogastric tube, and optimize cardiac status by treating arrhythmia, congestive heart failure (CHF), or myocardial infarction. Start broad-spectrum antibiotics early. Provide pain control while maintaining stable blood pressure.
Surgical Care
Before operative management of AMI, stabilize patients by means of intravenous (IV) fluid administration, antibiotic prophylaxis covering the colonic flora, nasogastric tube decompression, and bladder catheterization, with heparin or papaverine administered as indicated. Blood should be available. In all types of AMI, resection of necrotic bowel may be required if signs of peritonitis develop. Differentiation of
nonviable from viable bowel can be enhanced by intraoperative fluorescein administration. During laparotomy, 1 g of fluorescein is infused. Viable bowel fluoresces brightly under a Wood lamp, thus allowing the surgeon to better evaluate the segments that need resection. Because of fat absorption, fluorescein can be used only once. Most patients can benefit from a 24- to 48-hour second-look operation to assess for viability of the remaining bowel. Intraoperative fluorescein administration may be performed either at the primary operation or during the second-look operation.
Activity Restriction
Patients activities are dictated by their conditions. Bed rest to allow for monitoring and to reduce demand on cardiac output is balanced against ambulation to prevent DVT.
Prevention
Aside from timely diagnosis and treatment of predisposing conditions, there are no known preventive measures for AMI. In the presence of a clinical syndrome suggesting chronic mesenteric insufficiency, color Doppler evaluation of the mesenteric vessels may help identify at-risk patients for further workup and identify those who might need angioplasty
Medication Summary
Drug types employed in the treatment of acute mesenteric ischemia (AMI) include vasodilators, thrombolytics, anticoagulants, antibiotics, and analgesics. Withhold therapeutic drugs (except analgesics and prophylactic antibiotics) until the type of AMI present has been determined by means of computed tomography (CT) scanning or angiography.