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Amphetamine D02.092.471.683.152.110 a specific chem: do not confuse with AMPHETAMINES; d-amphetamine = DEXTROAMPHETAMINE; N-methylamphetamine = METHAMPHETAMINE A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE. Desoxynorephedrin Levoamphetamine Phenopromin l-Amphetamine Amfetamine Amphetamine Sulfate Amphetamine Sulfate (2:1) Centramina Fenamine Miquel Brand of Amfetamine Sulfate Mydrial Phenamine Thyramine levo-Amphetamine AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Adrenergic Agents Adrenergic Uptake Inhibitors Central Nervous System Stimulants Dopamine Agents
Scope Note
Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Allowable Qualifiers Pharm. Action Pharm. Action Pharm. Action Pharm.
Amphetamine
Action Pharm. Action Pharm. Action CAS Type 1 Name Registry Number Related Number Related Number Dopamine Uptake Inhibitors Sympathomimetics Benzeneethanamine, alpha-methyl-, (+-)300-62-9 60-13-9 (sulfate (2:1)) 60-15-1
Amphetamine
Amphetamines
MeSH Heading Tree Number Annotation Scope Note See Also See Also Allowable Qualifiers Registry Number Previous Indexing History Note
Amphetamines D02.092.471.683.152 GEN or unspecified; prefer specifics; do not confuse with AMPHETAMINE, a specific chem; Nmethylamphetamine = METHAMPHETAMINE Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation. Appetite Depressants Central Nervous System Stimulants AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR 0 Amphetamine (1966-1975) 76; was NON MESH before 1976
Unique ID D000662
Amphetamines
p-Hydroxyamphetamine [D02.092.471.683.152.500] Iofetamine [D02.092.471.683.152.535] Methamphetamine [D02.092.471.683.152.619] + 3,4-Methylenedioxyamphetamine [D02.092.471.683.152.660] N-Methyl-3,4-methylenedioxyamphetamine [D02.092.471.683.152.670] Phentermine [D02.092.471.683.152.766] + Butoxamine [D02.092.471.683.221] Dexfenfluramine [D02.092.471.683.338] Dimethoxyphenylethylamine [D02.092.471.683.386] Dobutamine [D02.092.471.683.410] Fendiline [D02.092.471.683.450] Fenfluramine [D02.092.471.683.467] + Hexoprenaline [D02.092.471.683.530] 2-Hydroxyphenethylamine [D02.092.471.683.545] Isoxsuprine [D02.092.471.683.560] Mescaline [D02.092.471.683.635] Methoxamine [D02.092.471.683.661] p-Methoxy-N-methylphenethylamine [D02.092.471.683.670] Nylidrin [D02.092.471.683.715] Octopamine [D02.092.471.683.725] Oxyfedrine [D02.092.471.683.775] Prenylamine [D02.092.471.683.825] Ritodrine [D02.092.471.683.870] Selegiline [D02.092.471.683.915] Suloctidil [D02.092.471.683.934] Verapamil [D02.092.471.683.953] + Return to Entry Page Link to NLM Cataloging Classification
Amphetamines
Dextroamphetamine
MeSH Heading Tree Number Scope Note Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term
Dextroamphetamine D02.092.471.683.152.110.200 The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic. d-Amphetamine Celltech Brand of Dextroamphetamine Sulfate Curban Dexamfetamine Dexamphetamine Dexedrine Dextro-Amphetamine Sulfate DextroStat Dextroamphetamine Sulfate GlaxoSmithKline Brand of Dextroamphetamine Sulfate Mallinckrodt Brand of Dextroamphetamine Sulfate Oxydess Pasadena Brand of Dextroamphetamine
Dextroamphetamine
Shire Brand of Dextroamphetamine Sulfate Vortech Brand of Dextroamphetamine Sulfate d-Amphetamine Sulfate dextro-Amphetamine
Allowable AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Qualifiers Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action Adrenergic Agents Adrenergic Uptake Inhibitors Central Nervous System Stimulants Dopamine Agents Dopamine Uptake Inhibitors Sympathomimetics
CAS Type Benzeneethanamine, alpha-methyl-, (S)1 Name Registry Number Online Note History Note Unique ID 51-64-9 use DEXTROAMPHETAMINE to search DEXTRO AMPHETAMINE 1966-76 77; was DEXTRO AMPHETAMINE 1963-76 D003913
Dextroamphetamine
Methamphetamine
Methamphetamine D02.092.471.683.152.619 A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
Annotation a CNS stimulant; smokable crystal methamphetamine, called "ice" by drug abusers, goes here
Entry Term Deoxyephedrine Entry Term Abbott Brand of Methamphetamine Hydrochloride Entry Term Desoxyephedrine Entry Term Desoxyn Entry Term Langly Brand of Methamphetamine Hydrochloride Entry Term Madrine Entry Term Metamfetamine Entry Term Methamphetamine Hydrochloride Entry Term Methylamphetamine Entry Term N-Methylamphetamine Allowable Qualifiers Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action CAS Type 1 Name AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Adrenergic Agents Adrenergic Uptake Inhibitors Central Nervous System Stimulants Dopamine Agents Dopamine Uptake Inhibitors Sympathomimetics Benzeneethanamine, N,alpha-dimethyl-, (S)-
Methamphetamine
Registry Number
537-46-2
Unique ID D008694
Methamphetamine
Methamphetamine
Methamphetamine D02.092.471.683.152.619 A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
Annotation a CNS stimulant; smokable crystal methamphetamine, called "ice" by drug abusers, goes here
Entry Term Deoxyephedrine Entry Term Abbott Brand of Methamphetamine Hydrochloride Entry Term Desoxyephedrine Entry Term Desoxyn Entry Term Langly Brand of Methamphetamine Hydrochloride Entry Term Madrine Entry Term Metamfetamine Entry Term Methamphetamine Hydrochloride Entry Term Methylamphetamine Entry Term N-Methylamphetamine Allowable Qualifiers Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action CAS Type 1 Name AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Adrenergic Agents Adrenergic Uptake Inhibitors Central Nervous System Stimulants Dopamine Agents Dopamine Uptake Inhibitors Sympathomimetics Benzeneethanamine, N,alpha-dimethyl-, (S)-
Methamphetamine
Registry Number
537-46-2
Unique ID D008694
Methamphetamine
Benzphetamine
Benzphetamine D02.092.471.683.152.619.307 A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
Entry Term Benzfetamine Entry Term Didrex Entry Term Pharmacia Brand of Benzfetamine Hydrochloride Allowable Qualifiers Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action CAS Type 1 Name Registry Number History Note AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Adrenergic Agents Adrenergic Uptake Inhibitors Central Nervous System Stimulants Dopamine Agents Dopamine Uptake Inhibitors Sympathomimetics Benzeneethanamine, N,alpha-dimethyl-N-(phenylmethyl)-, (S)156-08-1 91(66); was see under PHENETHYLAMINES 1966-90
Unique ID D001589
Benzphetamine
Organic Chemicals [D02] Amines [D02.092] Ethylamines [D02.092.471] Phenethylamines [D02.092.471.683] Amphetamines [D02.092.471.683.152] Methamphetamine [D02.092.471.683.152.619] Benzphetamine [D02.092.471.683.152.619.307] Return to Entry Page Link to NLM Cataloging Classification
Benzphetamine
2,5-Dimethoxy-4-Methylamphetamine
2,5-Dimethoxy-4-Methylamphetamine D02.092.471.683.152.391 A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD.
Entry Term 1-(2,5-Dimethoxy-4-Methylphenyl)-2-Aminopropane Entry Term 2 5 DOM Entry Term 2,5-Dimethoxy-4-Methylamphetamine Hydrochloride, (+,-)-Isomer Entry Term 2,5-Dimethoxy-4-Methylamphetamine Hydrochloride, (R)-Isomer Entry Term 2,5-Dimethoxy-4-Methylamphetamine Hydrochloride, (S)-Isomer Entry Term 2,5-Dimethoxy-4-Methylamphetamine, (+,-)-Isomer Entry Term 2,5-Dimethoxy-4-Methylamphetamine, (R)-Isomer Entry Term 2,5-Dimethoxy-4-Methylamphetamine, (S)-Isomer Entry Term 2,5-Dimethoxy-4-Methylamphetamine, Hydrochloride Entry Term DOM Allowable Qualifiers Pharm. Action Pharm. Action AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Hallucinogens Serotonin Agonists
CAS Type 1 Benzeneethanamine, 2,5-dimethoxy-alpha,4-dimethylName Registry Number Related Number Related Number Related Number 15588-95-1 15589-00-1 (HCl) 26011-50-7 ((+-)-isomer) 29243-80-9 ((+-)-isomer, HCl)
2,5-Dimethoxy-4-Methylamphetamine
Related Number Related Number Related Number Related Number History Note Unique ID
43061-13-8 ((R)-isomer) 43061-14-9 ((S)-isomer) 50505-88-9 ((R)-isomer, HCl) 50505-89-0 ((S)-isomer, HCl) 2001(1973) D004290
2,5-Dimethoxy-4-Methylamphetamine
p-Hydroxyamphetamine
MeSH Heading Tree Number Scope Note Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Allowable Qualifiers Pharm. Action Pharm. Action CAS Type 1 Name Registry Number Related Number Previous Indexing Previous Indexing History Note
p-Hydroxyamphetamine D02.092.471.683.152.500 Amphetamine metabolite with sympathomimetic effects. It is sometimes called alphamethyltyramine, which may also refer to the meta isomer, gepefrine. Hydroxyphenylisopropylamine Methyltyramine Norpholedrin Oxyamphetamine para-Hydroxyamphetamine Hydroxyamfetamine Hydroxyamphetamin Hydroxyamphetamine Hydroxyamphetamine Hydrobromide Paredrine AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Mydriatics Sympathomimetics Phenol, 4-(2-aminopropyl)103-86-6 306-21-8 (HBr) Amphetamine (1973-1974) Phenols (1968-1974) 91(75); was see under AMPHETAMINES 1975-90
p-Hydroxyamphetamine
Unique ID
D010136
p-Hydroxyamphetamine
Iofetamine
Iofetamine D02.092.471.683.152.535 An amphetamine analog that is rapidly taken up by the lungs and from there redistributed primarily to the brain and liver. It is used in brain radionuclide scanning with I-123.
Entry Term Iodine-123-IMP Entry Term N-Isopropyl-p-iodoamphetamine Entry Term Iofetamine Hydrochloride, I-123 Entry Term Iofetamine I-123 Entry Term N-Isopropyl-p-(Iodine-123)-Iodoamphetamine Entry Term N-Isopropyl-p-iodoamphetamine (I123) Hydrochloride Allowable Qualifiers Pharm. Action AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Radiopharmaceuticals
CAS Type 1 Benzeneethanamine, 4-iodo-alpha-methyl-N-(1-methylethyl)Name Registry Number Related Number Previous Indexing History Note 95896-48-3 85068-76-4 (123I labeled hydrochloride) Amphetamines (1980-1998) 99; use IOFETAMINE (NM) 1980-98
Unique ID D020367
Iofetamine
Ethylamines [D02.092.471] Phenethylamines [D02.092.471.683] Amphetamines [D02.092.471.683.152] Amphetamine [D02.092.471.683.152.110] + p-Chloroamphetamine [D02.092.471.683.152.200] 2,5-Dimethoxy-4-Methylamphetamine [D02.092.471.683.152.391] p-Hydroxyamphetamine [D02.092.471.683.152.500] Iofetamine [D02.092.471.683.152.535] Methamphetamine [D02.092.471.683.152.619] + 3,4-Methylenedioxyamphetamine [D02.092.471.683.152.660] N-Methyl-3,4-methylenedioxyamphetamine [D02.092.471.683.152.670] Phentermine [D02.092.471.683.152.766] + Return to Entry Page Link to NLM Cataloging Classification
Iofetamine
3,4-Methylenedioxyamphetamine
3,4-Methylenedioxyamphetamine D02.092.471.683.152.660 An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally.
Allowable AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Qualifiers Pharm. Action Pharm. Action Pharm. Action Adrenergic Uptake Inhibitors Hallucinogens Serotonin Agents
Previous Amphetamine (1973-1976) Indexing Previous Dioxoles (1974-1975) Indexing Previous Methyl Ethers (1973) Indexing History Note Unique ID 91(77); was see under AMPHETAMINES 1977-90 D015104
3,4-Methylenedioxyamphetamine
Amines [D02.092] Ethylamines [D02.092.471] Phenethylamines [D02.092.471.683] Amphetamines [D02.092.471.683.152] Amphetamine [D02.092.471.683.152.110] + p-Chloroamphetamine [D02.092.471.683.152.200] 2,5-Dimethoxy-4-Methylamphetamine [D02.092.471.683.152.391] p-Hydroxyamphetamine [D02.092.471.683.152.500] Iofetamine [D02.092.471.683.152.535] Methamphetamine [D02.092.471.683.152.619] + 3,4-Methylenedioxyamphetamine [D02.092.471.683.152.660] N-Methyl-3,4-methylenedioxyamphetamine [D02.092.471.683.152.670] Phentermine [D02.092.471.683.152.766] + Return to Entry Page Link to NLM Cataloging Classification
3,4-Methylenedioxyamphetamine
N-Methyl-3,4-methylenedioxyamphetamine
N-Methyl-3,4-methylenedioxyamphetamine D02.092.471.683.152.670 An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
Annotation street drug Ecstasy goes here; DF: note short X ref
Entry Term MDMA Entry Term Methylenedioxymethamphetamine Entry Term Ecstasy (Drug) Entry Term N-Methyl-3,4-methylenedioxyamphetamine Hydrochloride Allowable Qualifiers Pharm. Action Pharm. Action Pharm. Action CAS Type 1 Name Registry Number Related Number Previous Indexing Online Note History Note AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Adrenergic Uptake Inhibitors Hallucinogens Serotonin Agents 1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl42542-10-9 64057-70-1 (HCl) 3,4-Methylenedioxyamphetamine/analogs & derivatives (1984-1994) use N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE (NM) to search N-METHYL-3,4METHYLENEDIOXYAMPHETAMINE 1984-94 95; was N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE (NM) 1984-94
Unique ID D018817
N-Methyl-3,4-methylenedioxyamphetamine
N-Methyl-3,4-methylenedioxyamphetamine
Phenethylamines
MeSH Heading Tree Number Scope Note Allowable Qualifiers Registry Number Online Note History Note Unique ID
Phenethylamines D02.092.471.683 A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed) AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR 0 use PHENETHYLAMINES to search PHENYLETHYLAMINES 1966-67 68; was PHENYLETHYLAMINES 1963-67 D010627
Phenethylamines
Amphetamines [D02.092.471.683.152] + Butoxamine [D02.092.471.683.221] Dexfenfluramine [D02.092.471.683.338] Dimethoxyphenylethylamine [D02.092.471.683.386] Dobutamine [D02.092.471.683.410] Fendiline [D02.092.471.683.450] Fenfluramine [D02.092.471.683.467] + Hexoprenaline [D02.092.471.683.530] 2-Hydroxyphenethylamine [D02.092.471.683.545] Isoxsuprine [D02.092.471.683.560] Mescaline [D02.092.471.683.635] Methoxamine [D02.092.471.683.661] p-Methoxy-N-methylphenethylamine [D02.092.471.683.670] Nylidrin [D02.092.471.683.715] Octopamine [D02.092.471.683.725] Oxyfedrine [D02.092.471.683.775] Prenylamine [D02.092.471.683.825] Ritodrine [D02.092.471.683.870] Selegiline [D02.092.471.683.915] Suloctidil [D02.092.471.683.934] Verapamil [D02.092.471.683.953] + Phenoxybenzamine [D02.092.471.739] Return to Entry Page Link to NLM Cataloging Classification
Phenethylamines
Dextroamphetamine
MeSH Heading Tree Number Scope Note Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term Entry Term
Dextroamphetamine D02.092.471.683.152.110.200 The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic. d-Amphetamine Celltech Brand of Dextroamphetamine Sulfate Curban Dexamfetamine Dexamphetamine Dexedrine Dextro-Amphetamine Sulfate DextroStat Dextroamphetamine Sulfate GlaxoSmithKline Brand of Dextroamphetamine Sulfate Mallinckrodt Brand of Dextroamphetamine Sulfate Oxydess Pasadena Brand of Dextroamphetamine
Dextroamphetamine
Shire Brand of Dextroamphetamine Sulfate Vortech Brand of Dextroamphetamine Sulfate d-Amphetamine Sulfate dextro-Amphetamine
Allowable AA AD AE AG AI AN BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR Qualifiers Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action Pharm. Action Adrenergic Agents Adrenergic Uptake Inhibitors Central Nervous System Stimulants Dopamine Agents Dopamine Uptake Inhibitors Sympathomimetics
CAS Type Benzeneethanamine, alpha-methyl-, (S)1 Name Registry Number Online Note History Note Unique ID 51-64-9 use DEXTROAMPHETAMINE to search DEXTRO AMPHETAMINE 1966-76 77; was DEXTRO AMPHETAMINE 1963-76 D003913
Dextroamphetamine