PUBLICATIONS (1980-2011)

Mario P. Colombo

1. Parmiani G., Colombo M. P., Ballinari D. Expression of alien histocompatibility

antigens distinct from tumor-antigen on a murine fibrosarcoma. Int J Cancer, 26:
461-465, 1980.
2. Colombo MP, Parmiani G (1981) Importance of non-H-2 genes in the control of the
in vivo growth of the virus-induced lymphoma YC8. J Immunogenet., 9: 405-413.
3. Parmiani G, Sensi ML, Carbone G, Colombo MP, Pierotti MA, Ballinari D, Hilgers
J, Hilkens J (1982) Cross-reaction between tumor cells and allogeneic normal tissue.
Inhibition of a syngeneic lymphoma outgrowth in H-2 and non-H-2 alloimmune
BALB/c mice. Int J Cancer 29: 323-332.
4. Parmiani G, Pierotti MA, Colombo MP, Carbone G (1982) Abnormal expression of
histocompatibility antigens on cancer cells. Bull Cancer 69: 188-193.
5. Carbone G, Colombo MP, Sensi ML, Cernuschi A, Parmiani G (1983) In vivo
immunity to individual tumor-specific antigens on chemically induced BALB/c
fibrosarcomas. Int J Cancer 31: 483-489.
6. Colombo MP, Rodolfo M, Parmiani G (1983) H-2K restriction of the cell-mediated
lysis of a chemically-induced BALB/c fibrosarcoma. J Immunogenet 10: 337-340.
7. Colombo MP, Pierotti MA, Ballinari D, Parmiani G (1983) Expression of H-2 and
viral antigens and resistance to the anti-tumor lysis of tunicamycin-treated MBL-2
lymphoma cells. Immunobiology 165: 186-199.
8. Emanuelli H, Bandieramonte G, Marchesi R, Fava G, Rodari A, Colombo MP, Costa
A, Spinelli P, Zunino F, Costa F, Cascinelli N, Andreola S, Ariente R, Canti GF
(1983) Laser oncology in Italy: experimental research and clinical applications at the
National Cancer Institute, Milan. Laser in Surg & Med 2: 373-381.
9. Nanni P, Colombo MP, De Giovanni C, Lollini PL, Nicoletti G, Parmiani G, Prodi G
(1983) Impaired H-2 expression in B16 melanoma variants. J Immunoget 10: 361-
370.
10. Pierotti MA, Ballinari D, Colombo MP, Grazioli L, Parmiani G (1983) Role of
caroydrate prosthethic groups in the biosynthesis of membrane antigens and in H-2
restricted lysis of MBL-2 lymphoma cells. Transpl Proc 15: 2068-2073.
11. Colombo MP, Arioli I, Parmiani G (1984) Passive adoptive immunotherapy of a
low-immunogenic BALB/c lymphoma by syngeneic alloimmune T lymphocytes. Int
J Cancer 34: 807-813.
12. Colombo MP, Rodolfo M, Parmiani G (1985) Genetic unresponsiveness to a murine
fibrosarcoma determined by the host genetic environment but not by lymphocytes
precursor genotype. Tumori 71: 91-96.
13. Colombo MP, Parenza M, Parmiani G (1985) Adoptive immunotherapy of a
BALB/c lymphoma by syngeneic anti-DBA/2 immune lymphoid cells:
characterization of the effector population and evidence for the role of the hosts' non
T cells. Cancer Immunol Immunother 20: 198-204.
14. Formelli F, Bordoni T, Colombo MP (1985) Anti-tumor activity and effect on the
immune response of doxorubicin and 4'-deoxydoxorubicin (4'-Deoxy-DX) in rats
bearing Walker 256 carcinoma. In: Recent Advances in Chemotherapy (J Ishigami
ed), University of Tokyo Press, pp. 625-626.
15. Lollini PL, Colombo MP, De Giovanni C, Nicoletti G, Parmiani G, Prodi G, Nanni P
(1985) In vivo re-expression of H-2 antigens in B16 melanoma cells. Clin Exp
Immunogenet 2: 14-23.
16. Balsari A, Tona G, Colombo MP, Fossati G, Parmiani G (1986) Control of human
melanoma growth in nude mice by autologous, alloactivated peripheral blood
lymphocytes. Int J Cancer 38: 923-927.
17. Parmiani G, Sensi ML, Balsari A, Colombo MP, Gambacorti-Passerini C, Grazioli
L, Rodolfo M, Cascinelli N, Fossati G (1986) Adoptive immunotherapy of cancer
with immune lymphocytes: experimental and clinical studies. La Ricerca Clin Lab
16: 1-20.
18. Colombo MP, Jaenisch R, Wettstein PJ (1987) Integration and expression of
retrovirus leads to the expression of a histocompatibility antigens detected by skin
graft rejection. Proc Natl Acad Sci (USA) 84: 189-193.
19. Colombo MP, Melvold RW, Wettstein PJ (1987) Inheritance of a mutant
histocompatibility gene and a new mammary tumor virus genome in the B6.C-KH-
84 mouse strain. Immunogenetics 26: 99-104.
20. Parmiani G, Grazioli L, Sensi ML, Colombo MP, Rodolfo M (1987) Treatment of a
low immunogenic experimental tumors with tumor-immune or alloactivated
lymphocytes. Biochem Biophys Acta 907: 163-174.
21. Traversari C, Ferrari G, Grazioli L, Ballinari D, Colombo MP, Castelli C, Pierotti
MA, Parmiani G (1987) Ly-5.185 molecule is associated with thymic maturation of
lymphocytes but not with their cytotoxic activity. Clin Exp Immunogenet 4: 106-
114.
22. Wettstein PJ, Colombo MP (1987) Immunodominance in the T cell response to
multiple non-H-2 histocompatibilioty antigens. IV. Partial issue distribution and
mapping of immunodominant antigens. J Immunol 139: 2166-2171.
23. Colombo MP, Ferrari G, Parmiani G Wettstein PJ (1988) Retroviral heterogeneity in
mouse lymphomas: possible implication in expression of novel histocompatibility
antigens. Oncogene 2: 395-398.
24. Colombo MP, Galasso D, Ferrari G, Parmiani G (1988) Strain polymorphism and
tentative mapping of mouse ornithine decarboxylase. Nucleic Acid Res 16: 9075.
25. Wettstein PJ, Colombo MP, Jaenisch R (1988) Differential expression of integrated
Moloney-Murine leukemia virus in Mov mouse strains as detected by cytotoxic T
lymphocytes. J Immunol 140: 4337-4341.
26. Colombo MP, Ferrari G, Galasso D, Parmiani G (1989) Strain-specific retroviral
sequences are anomalously represented in DNA of mouse lymphomas. In: Molecolar
Probes Technology and Medical Applications (A Albertini ed) Raven Press, New
York, pp 271-278.
27. Colombo MP, Baracetti P, Schneider C, Cairo G (1989) Ava I RFLP at the gas-I
locus on mouse chromosome 12. Nucleic Acid Res 17: 5415.
28. Colombo MP, Biondi G, Galasso D, Baracetti P, Howe CC, Parmiani G (1989)
Osteonectin transcript and metastatic behaviour in v-ki-ras transformed fibroblasts.
Int J Cancer (s) 4: 76-77.
29. Colombo MP, Baracetti P, Cairo G, Schneider C, Parmiani G (1989) A Taq I RFLP
at the gas-2 locus. Nucleic Acid Res 17: 7545.
30. Desiderio MA, Lugaro G, Galasso D, Colombo MP (1990) Adrenergic and CA++
mediated increase in ornithine decarboxylase mRNA in regenerating rat liver. J
Biochem Pharmacol 40: 1605-1613.
31. Rivoltini L, Colombo MP, Supino R, Ballinari D, Tsuruo T, Parmiani G (1990)
Modulation of multidrug resistance by verapamil or mdr-1 anti-sense oligodeoxy
nucleotide does not change the high susceptibility to lymphokine-activated killers in
MDR-resistant human carcinoma (LoVo) line. Int J Cancer 46: 727-732.
32. Rivoltini L, Cattoretti G, Arienti F, Mastroianni A, Melani C, Colombo MP,
Parmiani G (1991) The high lysability of colon carcinoma cells resistant to
doxorubicin is associated with a high expression of ICAM-1, LFA-3, NCA and a less
differentiated phenotype. Int J Cancer 47: 746-754.
33. Colombo MP, Ferrari G, Biondi G, Galasso D, Howe CC, Parmiani G (1991)
SPARC/osteonectin/BM-40 expression in methylcholanthrene-induced
fibrosarcomas and in Kirsten-MSV transformed fibroblasts. Eur J Cancer 27: 58-62.
34. Melani C, Rivoltini L, Parmiani G, Calabretta B, Colombo MP (1991) Inhibition of
proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma
cell lines that express c-myb. Cancer Res 51: 2897-2901.
35. Colombo MP, Ferrari G, Stoppacciaro A, Parenza M, Rodolfo M, Mavilio F,
Parmiani G (1991) Granulocyte colony-stimulating factor (G-CSF) gene transfer
suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med 173: 889-
897.
36. Colombo MP, Parmiani G (1991) Tumor-cell targeted cytokine gene therapy.
Immunol Today 12: 249-250.
37. Colombo MP, Melani C (1991) Attivita` antitumorale dei neutrofili: ruolo del G-
CSF. Minerva Biotecnologica 3: 145-150.
38. Rodolfo M, Salvi C, Bassi C, Rovetta G, Melani C, Colombo MP, Parmiani G
(1991) Adjuvant immunotherapy with IL-2 and lymphocytes from tumor bearing
mice: in vitro tumor-stimulated lymphocytes are more effective than LAK cells. Nat
Imm Cell Groth Reg 10: 308-319.
39. Colombo MP, Martinotti A, Howard TA, D'Eustachio P, Seldin MF (1992)
Localization of growth arrest-specific genes on mouse chromosome 1, 7, 8, 11, 13
and 16. Mammalian Genome 2: 130-134.
40. Colombo MP, Mattei S, Parmiani G (1992): Cytokine gene transfer in tumor cells as
an approach to antitumor therapy. Int J Clin Lab. Res. 21: 278-282, 1992
41. Colombo MP, Maccalli C, Mattei S, Melani C, Radrizzani M, Parmiani G (1992)
Expression of cytokine genes, including IL-6, in human malignant melanoma cell
lines. Melanoma Res. 2: 181-189.
42. Colombo MP, Lombardi L, Stoppacciaro A, Melani C, Parenza M, Bottazzi B,
Parmiani G (1992) Granulocyte colony-stimulating (G-CSF) gene transduction in
murine adenocarcinoma drives neutrophil-mediated tumor inhibition in vivo:
neutrophils discriminate between G-CSF-producing and G-CSF-non producing
tumor cells. J Immunol, 149: 113-119.
43. Colombo MP, Modesti A, Parmiani G, Forni G. (1992). Local cytokine availability
elicits tumor rejection and systemic immunity through granulocyte - T-lymphocyte
cross talk. Cancer Res. 52: 4853-4857.
44. Re FC, Manenti G, Borrello MG, Colombo MP, Fisher JH, Pierotti M, Della Porta
G, Dragani TA (1992) Multiple molecular alterations in mouse lung tumors. Mol
Carcinogenesis, 5: 155-160.
45. Serra M, Morini NC, Scotlandi K, Fisher LW, Zini N, Colombo MP, Campanacci M,
Maraldi NM, Olivari S, Baldini N (1992) Evaluation of osteonectin as a diagnostic
marker of osteogenic bone tumors. Human Pathol, 23 :1326-1331
46. Martinotti A, Cariani CT, Melani C, Sozzi G, Spurr NK, Pierotti MA, Colombo MP.
(1992). Isolation and mapping to 17p12-13 of the human homologous of the murine
growth arrest specific Gas-3 gene. Human Mol. Genetics 1: 331-334.
47. Cairo G, Ferrero M, Biondi G, Colombo MP. (1992). Expression of growth specific
arrested gene (gas-1) in transformed cells. Br. J Cancer 66: 27-31.
48. Colombo, M. P. & Carè A. (1993) The role of cytokine in anti-tumor immune
response: from detection to gene therapy. ImmonoMethods. 3: 34-42.
49. Melani C, Mattia GF, Silvani A, Caré A, Rivoltini L, Parmiani G, Colombo MP.
(1993). IL-6 expression in human neutrophil and eosinophil peripheral blood
granulocytes. Blood 81: 2744-2749.
50. Rivoltini L, Viggiano V, Spinazze S, Santoro A, Colombo MP, Takatsu K, Parmiani
G (1993). Eosinophils from cancer patients treated with interleukin 2 show in vitro
antitumor activity due to in vivo release of IL-5. Int. J. Cancer 54: 8-15.
51. Moser B., Barella L., Mattei S., Boulay F., Colombo MP, Baggiolini M. (1993).
Expression of transcripts for two interleukin 8 receptors in human leukocytes and
melanoma cells. Biochem. J. 294: 285-292
52. Vagliani M., Melani C., Parmiani G., D'Eustachio P., Wettstein P.J., Colombo M.P.
(1993). Immunodominance in the T-cell response to multiple non-H-2
histocompatibility antigens. V. Chromosomal mapping of the immunodominant
cytotoxic T-cell target-1 (CTT-1). Immunogenetics 38: 157-160.
53. Stoppacciaro A., Melani C., Parenza M., Mastracchio A., Bassi C., Baroni C.,
Parmiani G., Colombo M.P. (1993). Regression of an established tumor genetically
modified to release G-CSF requires granulocyte-T cell cooperation and T cell-
produced IFNγ. J. Exp. Med. 178: 151-161.
54. Desiderio MA, Mattei S., Biondi G. Colombo MP (1993) Cytosolic and nuclear
spermidine acetyltransferases in growing NIH3T3 fibroblasts stimulated with serum
or polyamines: relantionship to polyamine biosynthetic decarbolaxylases and
hystone acetyltransferase. Biochem. J. 293: 475-479.
55. Edomi P., Martinotti A., Colombo MP, Schneider C. (1993) Sequence of human
gas3/pmp-22 full length cDNA. Gene. 126: 289-290.
56. Plaisance, S., Rubinstein, E., Alileche, A;, Han D. S., Sahraoni, Y., Mingari, M; C.,
Bellomo, R., Rinaldi D., Colombo, M. P., Jasmin, C., Carrel S., Azzarone, B. (1993).
Human melanoma cells express a functional interleukin-2 receptor. Int. J. Cancer 55:
164-170.
57. Cattoretti G., Schirò R., Orazi A., Soligo D., Colombo MP. (1993). The bone
marrow stroma in humans: Anti-nerve growth factor receptor antibodies selectively
stain reticular cells in vivo and in vitro. Blood 1726-1738.
58. Melani C., Silvani A., Parmiani G, Colombo M.P. (1993). Lymphotoxin gene
expression by melanocytes and melanoma cell lines and persistence of unspliced
mRNA. FEBS Lett. 335: 114-118.
59. Colombo, M. P. & Forni G. (1994). Cytokine gene transfer in tumor inhibition and
tentative tumor therapy: where are we now? Immunol. Today 15: 48-51.
60. Colombo M. P., Stoppacciaro A., Lombardi L. Granulocyte-T cell cooperation in the
rejection of a colon carcinoma transduced with the G-CSF gene. In "Cytokine
induced tumor immunogenicity: from exogenous molecules to gene therapy". G.
Forni, R. Foà, A. Santoni, L. Frati eds., pp 329-341, 1994
61. Cavallo F., Colombo M. P., Allione A., Bertini S., Consalvo M., Novelli F.,
Giovarelli M. Antitumor responses elicited by mouse adenocarcinoma cells
engineered to release IL-2 and IL-4. In "Cytokine induced tumor immunogenicity:
from exogenous molecules to gene therapy". G. Forni, R. Foà, A. Santoni, L. Frati
eds., pp 203-216, 1994
62. Mattei, S., Colombo, M. P., Melani, C., Silvani, A., Parmiani, G., Herlyn, H. (1994).
Expression of multiple cytokine-growth factors and their receptors in human
melanoma and melanocytes. Int. J. Cancer 56: 853-857.
63. Melani C., C. Chiodoni, F. Arienti, C. Maccalli, J. Sule-Suso, A. Anichini, M.P.
Colombo, G. Parmiani. (1994). Cytokine gene transduction in tumor cells: IL-2 or
IL-4 gene transfer in human melanoma cells. Nat. Immun. 13: 76-94.
64. Forni G., Giovarelli M., Cavallo F., Consalvo M., Allione A., Modesti A., Musiani
P., and Colombo M.P. (1994). Cytokine-induced tumor immunogenicity: from
exogenous cytokines to gene therapy. J. Immunother. 14: 253-257.
65. Musiani, P., Modesti A., Brunetti M., Modica A., Gulino A., Colombo M. P., Nanni
P., Cavallo F., Pericle F., Giovarelli M., Cavallo R., Forni G. (1994). The nature and
potential of the reactive response to mouse mammary adenocarcinoma cells
engineered with IL-2, IL-4 or IFNg gene. Nat. Imm. Cell Grow. Reg.13: 93-101.
66. Stoppacciaro A., Forni G., Colombo M. P. (1994). Different tumors transduced with
different cytokine genes as G-CSF and IL-2, show inhibition of tumor take through
neutrophils activation but differ in T cell functions. Folia Biologica 40: 89-99.
67. Caré, A., Mattia G., Montesoro E., Parolini I., Russo G., Colombo M. P., Peschle C.
(1994). c-fes expression in ontogenetic development and hematopoietic
differentiation. Oncogene 9: 739-747.
68. Ferrero, M., Desiderio, M.A., Martinotti, A., Melani, C., Bernelli-Zazzera, A.,
Colombo M.P., Cairo G. (1994). Expression of a growth-arrest specific gene (gas-6)
during liver regeneration: molecular mechanisms and signalling pathways. J. Cell.
Phys. 158: 263-269.
69. Vagliani M, D'Eustachio P., Colombo M. P. (1994). Refined localization of H7 and
CTT1 on distal chromosome 9. Immunogenetics 40: 79-81.
70. Cascinelli N., Foà R. , Parminani G., Arienti F., Belli F., Bernengo M.G., Clemente
C., Colombo M. P., Guarini A., Illeni M. T., Mascheroni L., Melani C., Prada A.,
Sulè-Suso J. (1994). Active immunization of metastatic melanoma patients with
interleukin-4 transduced, allogeneic melanoma cells. A phase I-II study. Human
Gene Therapy 5: 1059-1064.
71. Arienti F., Sulè-Suso J., Melani C., Maccalli C., Belli F., Illeni M. T., Anichini A.,
Cascinelli N., Colombo M. P., Parmiani G. (1994). Interleukin-2 gene transduced
human melanoma cells efficiently stimulate MHC-unrestricted and MHC-restricted
autologous lymphocytes. Human Gene Therapy 5: 1139-1150.
72. Pericle F., Giovarelli M., Colombo M. P., Ferrari G., Musiani P., Modesti A., Di
Pierro F., Forni G. (1994). An efficient Th2-type memory follow CD8+ lymphocyte
driven and eosinophil mediated rejection of a spontaneous mouse mammary
adenocarcinoma engineered to release IL-4. J. Immunol. 153: 5659-5673.
73. Allione A., Consalvo M., Nanni P;, Lollini PL., Cavallo F., Giovarelli M., Forni M.,
Gulino A., Colombo M.P., Dellabona P., Hock H., Blankenstein T., Rosenthal F. M.,
Gansbacher B., Colombo M. C., Musso T., Gusella L., Forni G. (1994). Immunizing
and curative potential of replicating and nonreplicating murine mammary
adenocarcinoma cells engineered with IL-2, IL-4, IL-6, IL-7, IL-10, TNFa, GM-
CSF, and IFNg gene or admixed with conventional adjuvants. Cance Res. 54: 6022-
6026.
74. Radrizzani M., P. Accornero, A. Amidei, A. Aiello, D. Delia, R. Kurrle, and M. P.
Colombo (1995) IL-12 inhibits apoptosis induced in a human Th1 clone by
gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation. Cellular
Immunol. 161: 14-21
75. Martinotti A. , A. Stoppacciaro, M. Vagliani, C. Melani, F. Spreafico, M. Wysocka,
G. Parmiani, G. Trinchieri, and M. P. Colombo. (1995) CD4 T cells inhibits in vivo
the CD8-mediated immune response against murine colon carcinoma cells
transduced with IL-12 genes. Eur. J. Immunol. 25: 137-146.
76. Silvani A., G. Ferrari, G. Paonessa, C. Toniatti, Giorgio Parmiani, and M. P.
Colombo. (1995). Down-regulation of interleukin 6 receptor a chain in interleukin 6
transduced melanoma cells causes resistance to interleukin 6 but not to Oncostatin
M. Cancer Res. 55: 2200-2205.
77. Melani C., S.M. Pupa, A. Stoppacciaro, S. Ménard, M.I. Colnaghi, G. Parmiani,
M.P. Colombo. An in vivo model to compare human leukocyte infiltration in
carcinoma xenografts producing different chemokines. Int. J. Cancer, 572-578
78. Melani C., J. Sulè-Suso, F. Arienti, C. Maccalli, F. Passerini, M.P. Colombo, G.
Parmiani. (1995) A human melanoma cell line transduced with an interleukin-4 gene
by a retroviral vector releases biologically active IL-4 and maintains the original
tumor antigenic phenotype. Hum. Gene Ther., 6: 1427-1436.
79. De Giovanni C., C. Melani, P. Nanni, L. Landuzzi, G. Nicoletti, F. Frabetti, C.
Griffoni, M.P. Colombo, P.L. Lollini. (1995). Redundancy of autocrine loops in
human rhabdomyosarcoma cells. Induction of differentiation by suramin. Br. J.
Cancer, 72: 1224-1229.
80. Sulè-Suso J., F. Arienti, C. Melani, M. P. Colombo, G. Parmiani. A B7-1 transduced
human melanoma line stimulates proliferation and cytotoxicity of autologous and/or
allogeneic lymphocytes. Eur. J. Immunol. 1995 25: 2737-2742
81. Parmiani G. and M. P. Colombo (1995) Somatic gene therapy of human melanoma:
preclinical studies and early clinical trails. Melanoma Res. 5: 295-301.
82. Colombo M. P.and Rodolfo M. (1995) Tumor cells engineered to produce cytokine
or co-factors as cellular vaccines: do animal studies really support clinical trials ?
Cancer Immunol. Immunother. 41: 260-270.
83. Sulé-Suso J., F. Arienti, F. Belli, C. Melani, L. Mascheroni, M. P. Colombo, N.
Cascinelli, G. Parmiani (1995) Vaccination of melanoma patients with Interleukin-2
transduced, allogeneic melanoma cells: an overview. In The Internet Book of Gene
Therapy. R. B. Sobol and K. J. Scanlon Ed., Appleton & Lange.
84. Colombo M. P., L. Lombardi, C. Melani, M. Parenza, C. Baroni, L. Ruco, A.
Stoppacciaro. (1996) Hypoxic tumor cell death and modulation of endothelial
adhesion molecules in the regression of G-CSF transduced tumors. Am. J. Pathol.
148: 473-483
85. Paglia P., C. Chiodoni, M. Rodolfo and M. P. Colombo (1996) Murine dendritic
cells loaded in vitro with soluble protein prime CTL against tumor antigen in vivo. J.
Exp. Med. 183: 317-322.
86. Vagliani M., Rodolfo M;, Cavallo F., Parenza M;, Melani C., Parmiani G., Forni G.,
Colombo M. P. (1996). IL-12 potentiates the curative effect of a vaccine based on
IL-2 transduced tumor cells. Cancer Res. 56: 467-470
87. Colombo M. P., M. Vagliani, F. Spreafico, M. Parenza, C. Chiodoni, C. Melani, and
A.Stoppacciaro. (1996) The amount of IL-12 available at the tumor site is critical for
tumor regression. Cancer Res. 56: 2531-2534.
88. Meazza R., Verdiani S., Biassoni R., Coppolecchia M., Orengo A., Colombo M. P.,
Azzarone B., Ferrini S. Identification of a novel IL-15 transcript isoform generated
by alternative splicing in human small cell lung cancer. Oncogene, 12: 2187-2192.
89. Carè A., Silvani A., Meccia E., Mattia G., Stoppacciaro A., Parmiani G., Peschle C.
and Colombo M. P. (1996) HOXB7 constitutively activates the bFGF in melanoma.
Mol. Cell. Biol. 16: 4842-4851.
90. Chirivi R.G.S., Chiodoni C., Musiani P., Garofalo A., Bernasconi S., Colombo M.
P., Giavazzi R. (1996) IL-1a gene transfected human melanoma cells increase tumor
cell adhesion to endothelial cells and their retention in the lung of nude mice. Int. J.
Cancer 67: 856-863
91. Rodolfo M., Zilocchi C., Melani C., Vagliani M., Cappetti B., Arioli I., Parmiani G.,
and Colombo M. P. (1996) Immunotherapy of experimental metastases by
vaccination with interleukin gene transduced adenocarcinoma cells sharing tumor-
associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell
vaccine. J. Immunol. 157: 5536-5542
92. Arienti F., Sulé-Suso J., Belli F., Mascheroni G., Rivoltini L., Melani C., Maio M.,
Cascinelli C., Colombo M.P., Parmiani G. (1996). Limited antitumor T cell response
in Melanoma patients vaccinated with interleukin-2 gene-transduced allogeneic
melanoma cells. Human Gene Therapy 7: 1955-1963
93. Bain C., Merrouche Y., Puisieux I., Duc A., Colombo M.P., Favrot M. (1996). B7.1
gene transduction of human renal-cell-carcinoma cell lines restores the proliferative
response and cytotoxic function of allogeneic T cells. Int. J. Cancer 67: 769-776.
94. Colombo M. P., Forni G. (1997) Cytokine gene transfer strategies. Cancer Met. Rev.
16: 421-432
95. Musiani P., Modesti A., Giovarelli M., Cavallo F., Colombo M.P., Lollini P.L.,
Forni G. (1997). Cytokines and tumor-cell death: a question of choice. Immunol.
Today 18: 32-36.
96. Accornero P., Radrizzani M., Delia D., Gerosa F., Kurle R.,and Colombo M. P.
(1997) Differential susceptibility to HIV-gp120-induced apoptosis in CD4+ T cell
clones with different T helper phenotypes: role of FAS/FAS-ligand interactions.
Blood 89: 558-569.
97. Parmiani G., Colombo M. P., Melani C., Arienti F. (1997); Cytokine gene
transduction in the immunotherapy of tumors. Advances in Pharmacol. 40: 259-307.
98. Cavallo F., Signorelli P., Giovarelli M., Musiani P., Modesti A., Brunda M.,
Colombo M. P., Forni G. (1997). Antitumor efficacy of adenocarcinoma cells
engineered to release IL-12 as opposed to other cytokines and comparison with that
of recombinant IL-12. J. Natl. Cancer Inst. 89: 1049-1058.
99. Paglia, P., Arioli, I., Frahm, N., Chakraborty, T., Colombo, M. P., Guzmàn, C. A.
(1997). The defined attenuated listeria monocytogenes ∆mp12 mutant is an effective
 oral vaccine carrier to trigger a long-lasting immune response against a mouse
fibrosarcoma. Eur. J. Immunol. 27:1570-1575, 1997
100. Parmiani G., Colombo M. P., Melani C. (1997). Immunotherapy, gene therapy,
cytokines and cancer. In "The cytokine network and immune functions" Theze J ed,
Paris
101. Belli F., Aienti F., Sulé-Suso J., Clemente C., Mascheroni L., Cattelan A.,
Sanantonio C., Gallini G. F., Melani C., Rao S., Colombo M. P., Maio M., Cascinelli
N., Parmiani G. (1997); Active immunization of metastatic melanoma patients with
interleukin-2 transduced allogeneic melanoma cells: evaluation of efficacy and
tolerability. Cancer Immunol. Immunother. 44: 197- 203.
102. Benedetti S, DiMeco F, Pollo B, Cirenei N, Colombo BM, Bruzzone MG, Cattaneo
E, Vescovi A, DiDonato S, Colombo MP and Finocchiaro G. Limited efficacy of the
HSV-TK/GCV system for gene therapy of malignant gliomas and perspectives for
the combined transduction of the IL-4 gene. Human Gene Ther. 8: 1345-1353, 1997
103. Radrizzani M., Accornero P., Delia D., Kurrle R.and Colombo M. P. (1997)
Apoptosis induced by HIV-gp120 in a Th1 clone involves the generation of reactive
oxygen intermediates downstream CD95 triggering. FEBS Letters 411: 87- 92.
104. Stoppacciaro A., Paglia P., Lombardi L., Parmiani G., Baroni C. and Colombo M. P.
(1997) Genetic modification of a carcinoma with the IL-4 gene increases the influx
of dendritic cells relative to other cytokines. Eur. J. Immunol. 27: 2375-2382
105. Di Meco F., Benedetti S., Colombo M.P., Finocchiaro G. (1997) Perspectives for the
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106. Nanni P, Rossi I, De Giovanni C, Landuzzi L, Nicoletti G, Stoppacciaro A, Colombo
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107. Caré A, Silvani, A, Meccia E, Mattia G, Peschle C, and Colombo MP (1998)
Transduction of the SkBr3 breast carcinoma cell line with the HOXB7 gene induces
bFGF expression, increases cell proliferation and reduces growth factor dependence.
Oncogene 16: 3285-3289.
108. Sfondrini L, Morelli D, Menard S, Mayer JAM, Sinh M, Melani C, Terrazzini N,
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murine melanoma cells transduced with the Mycobacterium tuberculosis gene
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109. Rivoltini L, Radrizzani M, Accornero P, Squarcina P, Chiodoni C, Mazzocchi A,
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apoptosis and use Fas/FasL-independent mechanisms for tumor killing. J. Immunol.
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110. Pizzato M., Franchin E., Calvi P., Boschetto R., Colombo M.P., Ferrini S., Palù G.
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vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for
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111. Zilocchi C, Stoppacciaro A., Chiodoni C., Parenza M., Terrazzini N., and Colombo
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112. Boggio K, Nicoletti G, Di Carlo E, Cavallo F, Landuzzi L, Melani C, Giovarelli M,
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spontaneous mammary adenocarcinomas in HER-2/neu transgenic mice. J Exp Med
188: 589-596.
113. Paglia P., Medina E., Arioli I., Guzman C. A. and Colombo M. P. (1998). Oral DNA
vaccination with Salmonella typhimurium mediates gene transfer to antigen
presenting cells and results in protective immunity against a murine fibrosarcoma.
Blood 92: 3172-3176
114. Melani C., Figini M., Nicosia D., Luison E., Ramakrishna V., Casorati G., Parmiani
G., Eshhar Z., Canevari S., and Colombo M. P. (1998). Targeting of interleukin-2 to
human ovarian carcinoma by fusion with a single-chain Fv of anti-folate receptor
antibody. Cancer Res. 58: 4146-4154.
115. Accornero, P., Radrizzani M., Caré A., Mattia G., Chiodoni C., Kurrle R., Colombo
M.P. (1998). HIV/gp120 and PMA/ionomycin induced apoptosis but not activation
induced cell death require PKC for Fas-L upregulation . FEBSLetter 436: 461-465.
116. Rodolfo M., Melani C., Zilocchi C., Cappetti B., Luison E., Arioli I., Parenza M.,
Canevari S.and Colombo M. P. (1998) IgG2a induced by IL-12-producing tumor cell
vaccines but not IgG1 induced by IL-4 vaccine are associated with the eradication of
experimental metastases. Cancer Res. 58: 5812-5817.
117. Belardelli F., Ferrantini M., Santini S., Baccarini S., Proietti E., Colombo M.P.,
Sprent J., Tough D.F. (1998). Tumor cells expressing IFN-a1 induce The induction
of in vivo proliferation of long-lived CD44hi CD8+ T cells after injection of tumor
cells expressing IFN-a1 into syngeneic mice. Cancer Res. 58: 5795-5804.
118. Di Carlo E, Modesti A, Coletti A, Colombo MP, Giovarelli M, Forni G, Diodoro
MG, Musiani P (1998). Interaction between endothelial cells and the secreted
cytokine drives the fate of an IL4- or an IL5-transduced tumour.J Pathol. 186: 390-
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119. Belli F., Mascheroni L., Gallino G., Lenisa L., Arienti F., Melani C., Colombo M.P.,
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120. Benedetti S., Di Meco F., Cirenei N., Bruzzone M.G., Pollo B., Florio N., Caposio
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121. Cavallo F, Di Carlo E, Butera M, Verrua R, Colombo M P, Musiani P, Forni G
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122. Chiodoni C., Paglia P., Stoppacciaro A., Rodolfo M., Parenza M. and Colombo M.
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CD40L genes, take up and present endogenous tumor-associated antigens and prime
naive mice for a CTL response. J. Exp. Med. 190: 125-133
123. Benedetti S., Bruzzone M.G., Pollo B., DiMeco F., Magrassi L., Pirola B., Cirenei
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by retroviral-mediated delivery of the interleukin-4 gene. Cancer Res 59: 645-652.
124. Medina E., Guzman C A , Staender L H, Colombo M P, Paglia P (1999) Salmonella
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125. Rodolfo M., Zilocchi C., Cappetti B., Parmiani G., Melani C., and Colombo M. P.
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associated with GM-CSF producing CD8 lymphocytes recognizing tumor antigens
that are not immunoselected. Gene Therapy 6: 865-872.
126. Caré A., Valtieri M., Mattia G., Meccia E., Masella B., Luchetti L., Colombo M. P.,
Peschle C. (1999). Enforced expression of HOXB7 promotes hematopoietic stem
cell proliferation and myeloid-restricted progenitor differentiation. Oncogene 18:
1993-2002
127. Todryk S, Melcher AA, Hardwick N, Linardakis E, Bateman A, Colombo MP,
Stoppacciaro A, Vile RG (1999) Heat shock protein 70 induced during tumor cell
killing induces Th1 cytokines and targets immature dendritic cell precursors to
enhance antigen uptake. J Immunol. 163:1398-1408.
128. Rodolfo M., Zilocchi C., Accornero P., Cappetti B., Arioli I., and Colombo M.P.
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lymphocytes that cure lung metastases upon adptive transfer. J. Immunol. 163: 1923-
1928.
129. Neglia F, Orengo AM, Cilli M, Meazza R, Tomassetti A, Canevari S, Melani C,
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associated antigen folate receptor alpha (FRalpha) induces cytotoxic T lymphocyte
and antibody responses in mice. Cancer Gene Ther. 6:349-357.
130. Fonsatti E, Lamaj E, Coral S, Sigalotti L, Nardi G, Gasparollo A, Colombo MP,
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interaction increasing the release of soluble intercellular adhesion molecule 1 by
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131. Sard L, Accornero P, Tornielli S, Delia D, Bunone G, Campiglio M, Colombo MP,
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FHIT is involved in the regulation of apoptosis and in cell cycle control. Proc Natl
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132. Rodolfo M, Colombo MP (1999). Interleukin-12 as an adjuvant for cancer
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133. Bordignon C, Carlo-Stella C, Colombo MP, De Vincentiis A, Lanata L, Lemoli RM,
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134. Arienti F, Belli F, Napolitano F, Sule-Suso J, Mazzocchi A, Gallino GF, Cattelan A,
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135. Paglia P., Colombo M. P. (1999) Presentation of tumor antigens. The role of
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136. Bocchia M, Bronte V, Colombo MP, De Vincentiis A , Di Nicola M , Forni G,
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137. Medina E., Paglia P., Rohde M., Colombo, M.P., and Guzman C. A. (2000)
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immune responses in vivo-activated promoters. Eur J. Immunol. 30: 768-777.
138. DiMeco F, Rhines LD, Hanes J, Tyler BM, Brat D, Torchiana E, Guarnieri M,
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 delivery of IL-12 against intracranial 9L gliosarcoma in rats. J Neurosurg. 92: 419-
427.
139. Forni G., Lollini P.L., Musiani P., Colombo M.P. (2000). Immunoprevention of
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140. Montosi G., Paglia P., Garuti C, Guzman C.A., Bastin J.M., Colombo M.P.,
Pietrangelo A. (2000). Wild type HFE protein normalizes transferrin iron
accumulation in macrophages from subjects with ereditary hemocromatosis. Blood
96:1125-1129.
141. Schadendorf D., Belardelli F., Ferrantini M., Parmiani G., Colombo M.P. (2000).
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142. Melero I., Vile R.G., Colombo M. P. (2000) Feeding dendritic cells with tumor
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143. Paglia P., Terrazzani N., Schultze K., Guzman C.A., Colombo M. P. (2000) In vivo
correction of genetic defects of monocyte/macrophages using attenuated Salmonella
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144. Sfondrini L, Rodolfo M, Singh M, Colombo MP, Colnaghi MI, Menard S, Balsari A.
(2000) Cooperative effects of Mycobacterium tuberculosis Ag38 gene transduction
and interleukin 12 in vaccination against spontaneous tumor development in proto-
neu transgenic mice. Cancer Res 60:3777-3781.
145. Rovero S, Amici A, Di Carlo E, Bei B, Nanni P, Quaglino E, Porcedda P, Boggio K,
Smorlesi A, Lollini L, Landuzzi L, Colombo M P, Giovarelli M, Musiani P and
Forni G (2000) DNA vaccination against rat HER-2/neu p185 more effectively
inhibits spontaneous carcinogenesis than transplantable carcinomas in transgenic
BALB/c mice. J. Immunol 165: 5133-5142.
146. Coral S., Fonsatti E., Sigalotti L., De Nardo C., Visintin A., Nardi G., Colozzi F.,
Colombo M. P., Romano G., Altomonte M., Maio M. (2000). Overexpressiion of
protectin (CD59) down-modulates the susceptibility of human melanoma cells to
homologous complement. J. Cell Physiol. 185: 317-323.
147. Di Carlo E., Forni G., Lollini PL. Colombo M.P., Modesti A., Musiani P. (2001).
The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood
97: 339-345.
148. Strasly M., Cavallo F., Verrua R., Geuna M., Colombo M. P., Forni G. and
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149. Mazzocchi A., Melani C., Rivoltini L., Castelli C., Lombardo C., Colombo MP.,
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150. Carè A., Felicetti F., Meccia E., Bottero L., Parenza M., Stoppacciaro P., Peschle C.
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151. Chiodoni C. , Stoppacciaro A. , Sangaletti S. , Gri G. , Cappetti B. , Koezuka Y. and
Colombo M. P. (2001). Different requirements for a-galactosylceramide and rIL-12
antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases.
Eur.J. Immunol. 31: 3101-3110.
152. Nanni P., Nicoletti G., De Giovanni C., Landuzzi L., Di Carlo E., Cavallo F., Pupa
S. M., Rossi I., Colombo M.P., Ricci C., Astolfi A., Musiani P., Forni G., Lollini PL.
(2001). Combined allogeneic tumor cell vaccination and systemic inteleukin 12
 prevents mammary carcinogenesis in HER-2/neu transgenic mice. J. Exp. Med. 194:
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153. Colombo M. P., Guzman C. A., Pietrangelo A., Paglia P. (2001) Mutant Salmonella
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154. Colombo MP, Forni G (2001) Immunoprevention of cancer: In Encyclopedic
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155. Cavallo F, Carlo ED, Quaglin E, Jezzi M, Strasly M, Bussolino F, Colombo MP,
Nanni P, Lollini PL, Musiani P, Forni G. (2001). Prevention by delay: nonspecific
immunity elicited by IL-12 hinders Her-2/neu mammary carcinogenesis in
transgenic mice. J Biol Regul Homeost Agents. 15: 351-3588.
156. Paglia P.& Colombo M.P.(2002) Macrophages as antigen presenting cells:
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157. Colombo M.P. and Trinchieri G. (2002). Cytokine and cancer. : Cytokine Growth
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158. Colombo M. P. and Trinchieri G. (2002). Interleukin-12 in anti-tumor immunity and
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159. Comes A. Di Carlo E., Musiani P., Rosso O., Meazza R., Chiodoni C., Colombo M.
P., Ferrini S. (2002). IFN-g-independent synergistic effects of IL-12 and IL-15
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160. Gri G., Chiodoni C., Gallo E., Stoppacciaro A., Liew F. Y, and Colombo MP. (2002)
Antitumor effect of IL-12 in the absence of endogenous IFN-gamma: a role for
intrinsic tumor immunogenicity and IL-15. Cancer Res 62: 4390-4397.
161. Sfondrini L., Besusso D., Zoia M. T., Rodolfo M., Invernizzi A. M., Taniguchi M.,
Nakayama T., Colombo M. P., Menard S., Balsari A. (2002). Absence of the CD1
molecule up-regulates antitumor activity induced by CpG oligodeoxynucleotides in
mice. J. Immunol. 169: 151-158.
162. Vicari A., Chiodoni C. Vaure C., Ait-Yahia S., Dercamp C., Matsos F., Reynard O.,
Taverne C., Merle P., Colombo M.P., O’Garra A., Trinchirti G., Caux C. (2002).
Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory
oligonucleotide and anti-Interleukin10 receptor antibody. J Exp Med 196: 541-549.
163. Wiegant J, van Hall T, van der Burg M, Colombo M, Tanke HJ, Offringa R,
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for detection of cross-contamination and in vitro progression in commonly used
murine tumor cell lines. Cancer Genet Cytogenet. 2002 Dec;139(2):126-32.
164. Bronte V., Serafini P., De Santo C., Marigo I., Tosello V., Mazzoni A., Segal DM.,
Staib C., Lowel M., Sutter G., Colombo MP., Zanovello P. (2003). IL-4 induced
arginase 1 suppresses alloreactive T cells in tumor bearing mice. J Immunol
170:270-278.
165. Curti A. Parenza M., Colombo MP. (2003) Autologous and MHC class I-negative
allogeneic tumor cells secreting IL-12 together cure disseminated A20 lymphoma.
Blood 101: 568-75
166. Curcio C. Di Carlo E. Clynes R, Smyth M.J., Boggio K., Quaglino E., Spadaro M.,
Colombo MP., Amici A., Lollini PL., Musiani P., Forni G. (2003). Nonredontant
roles of antibody, cytokines and perforin for the immune eradication of established
Her-2/neu carcinomas. J Clin Invest. 111: 1161-1170.
167. Gri G., Gallo E., Di Carlo E., Musiani P, and Colombo MP. (2003). OX40 ligand-
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signaling to boost T cell antitumor response. J. Immunol 170: 99-106
168. Meccia E, Bottero L, Felicetti F, Peschle C, Colombo MP, Carè A. (2003). HOXB7
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169. Melani, C., Chiodoni C., Forni G., Colombo MP. (2003). Myeloid cell expansion
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170. Rotta G., Emmerson W. E., Sangaletti S., Bennett C., Colombo M. P., Steinman R.
M., Randolph G. J., and M. Rescigno. (2003). Bacteria-based intradermal
vaccination is inefficient due to the induction of a potent inflammatory response that
impedes DC differentiation and migration. J. Exp.Med. 198: 1253-1263.
171. Sangaletti S., Stoppacciaro A., Guiducci C., Torrisi M.R., Colombo M.P. (2003).
Leukocytes rather than tumor produced SPARC determines stroma and collagen type
IV deposition in mammary carcinoma. J Exp Med. 198: 1475-1485. (IF 15.302)
172. Cerisano V, Aalto Y, Perdichizzi S, Bernard G, Manara MC, Benini S, Cenacchi G,
Preda P, Lattanzi G, Nagy B, Knuutila S, Colombo MP, Bernard A, Picci P,
Scotlandi K. (2004). Molecular mechanisms of CD99-induced caspase independent-
cell death and cell-cell adhesion in Ewing's sarcoma cells: Actin and Zyxin as key
intracellular mediators. Oncogene 23: 5664-5674. (IF 6.495)
173. Di Carlo E, Comes A, Orengo AM, Rosso O, Meazza R, Musiani P, Colombo MP,
Ferrini S. (2004). IL-21 induces tumor rejection by specific CTL and IFN-gamma-
dependent CXC chemokines in syngeneic mice. J. Immunol. 172: 1540-1547.
174. Felicetti F, Bottero L, Felli N, Mattia G, Labbaye C, Alvino E, Peschle C, Colombo
MP, Care A. (2004). Role of PLZF in melanoma progression.Oncogene 23:4567-
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175. Guiducci, C., Di Carlo, E., Parenza, M., Hitt, M., Giovarelli, M., Musiani, P., and
Colombo, M. P. (2004). Intralesional injection of adenovirus encoding CCL16
inhibits mammary tumor growth and prevents metastatic-induced death after surgical
removal of the primary tumor. J Immunol, 172: 4026-4036 (IF 6.702)
176. Massa C, Guiducci C, Arioli I, Parenza M, Colombo MP, Melani C. (2004).
Enhanced Efficacy of Tumor Cell Vaccines Transfected with Secretable hsp70.
Cancer Res. 64:1502-1508. (IF8.649)
177. Melani C, Stoppacciaro A, Foroni C, Felicetti F, Care A, Colombo MP. (2004).
Angiopoietin decoy secreted at tumor site impairs tumor growth and metastases by
inducing local inflammation and altering neoangiogenesis. Cancer Immunol
Immunother. 53: 600-608 (IF 3.130)
178. Sfondrini L, Besusso D, Bronte V, Macino B, Rossini A, Colombo MP, Menard S,
Balsari A. (2004). CpG-Oligodeoxynucleotides activate tyrosinase-related protein 2-
specific T lymphocytes but do not lead to a protective tumor-specific memory
response. Cancer Immunol Immunother. 53: 697-704 3.130. (IF 3.130)
179. Vicari AP, Vanbervliet B, Massacrier C, Chiodoni C, Vaure C, Ait-Yahia S,
Dercamp C, Matsos F, Reynard O, Taverne C, Merle P, Colombo MP, O'Garra A,
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180. Guiducci, C,. Valzasina, B. Dislich H., and Colombo M. P. (2005) CD40L on
CD4+CD25+ regulatory T cells stimulates DC to produce the IL-2 necessary for
their homeostasis. Eur. J. Immunol. 35: 557-567. (IF 4.536)
181. Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, Colombo MP (2005)
Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory
activity: a novel regulatory role for OX40 and its comparison with GITR. Blood
105: 2845-2851. (IF 10.120)
182. Guiducci C., Vicari A.P., Sangaletti S., Trincheri G., Colombo M.P. (2005).
Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells
towards tumor rejection. Cancer Res. 65: 3437-46. (IF 8,649)
183. Avogadri F., Martinoli C., Petrovska L., Chiodoni C., Colombo M. P., Dougan G.,
Rescigno M. (2005). Cancer immunotherapy based on bacterial infection and killing
of infected tumor cells. Cancer Res. 65: 3920-7. (IF 8.649)
184. Serafini P., De Santo C., Marigo I., Dolcetti L., Bolla M., Del Soldato P., Melani C.,
Guiducci C., Colombo M. P., Iezzi M., Musiani P., Zanovello P., Bronte V. (2005)
Nitroaspirin corrects immune dysfunction in tumor-bearing hosts. Proc. Natl. Acad.
Sci USA 102: 4185-4190. (IF 10.272).
185. Dalerba P., Guiducci C., Poliani P. L., Cifola I., Parenza M., Frattini, M. Gallino G.,
Carnevali I., Di Giulio I., Andreola S., Lombardo C., Rivoltini L., Schweighoffer T.,
Belli F., Colombo M. P., Parmiani G., and Castelli C.. (2005). Reconstitution of
Human Telomerase Reverse Transcriptase Expression Rescues Colorectal
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Constitutive Trait of Tumor Cells. Cancer Res. 65: 2321-2329. (IF 8,649)
186. Benini S, Perbal B, Zambelli D, Colombo MP, Manara MC, Serra M, Parenza M,
Martinez V, Picci P, Scotlandi K. (2005). In Ewing's sarcoma CCN3(NOV) inhibits
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Oncogene 4349-61. (IF 6.495)
187. Sangaletti S. Gioiosa L. Guiducci C. Rotta G., Rescigno M., Stoppacciaro A.,
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188. Massa C., Melani C. and Colombo MP. (2005). Chapern and adjuvant activity of
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189. Colombo MP. and Mantovani A. (2005). Targeting myelomonocytic cells to revert
inflammation-dependent cancer promotion. Cancer Res. 65: 9113-16
190. Airoldi I., Di Carlo E., Cocco C., Sorrentino C., Fais F., Cilli M., D’Antuono T.,
Colombo MP., Pistoia V. (2005). Lack of murine IL-12Rbeta2 signalling
predisposes to autoimmunity and B cell maglignancies. Blood 106: 3846-3853.
191. Curti A, Pandolfi S, Aluigi M, Isidori A, Alessandrini I, Chiodoni C, Testoni N,
Colombo MP, Baccarani M, Lemoli RM. (2005) Interleukin-12 production by
leukemia-derived dendritic cells counteracts the inhibitory effect of leukemic
microenvironment on T cells. Exp Hematol. 33: 1521-30.
192. Tirapu I, Huarte E, Guiducci C, Arina A, Zaratiegui M, Murillo O, Gonzalez A,
Berasain C, Berraondo P, Fortes P, Prieto J, Colombo MP, Chen L, Melero I. (2006)
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Carcinoma. Cancer Res.66:2442-2450. IF 7.690
193. Aluigi M, Fogli M, Curti A, Isidori A, Gruppioni E, Chiodoni C, Colombo MP,
Versura P, D'Errico-Grigioni A, Ferri E, Baccarani M, and Lemoli RM. (2006).
Nucleofection is an efficient non-viral transfection tecqnique for human bone
marrow-derived mesenchymal stem cells. Stem Cells 24: 454-461
194. Comes A, Rosso O, Orengo AM, Di Carlo E, Sorrentino C, Meazza R, Piazza T,
Valzasina B, Nanni P, Colombo MP, Ferrini S. (2006) CD25+ Regulatory T Cell
Depletion Augments Immunotherapy of Micrometastases by an IL-21-Secreting
Cellular Vaccine. J Immunol. 176:1750-8. IF 6.486
195. Manara MC, Bernard G, Lollini PL, Nanni P, Zuntini M, Landuzzi L, Benini S,
Lattanzi G, Sciandra M, Serra M, Colombo MP, Bernard A, Picci P, Scotlandi K.
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196. Valzasina B., Piconese S. , Guiducci C. and Colombo M. P. (2006) Tumor-induced
expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus
and proliferation independent. Cancer Res . 66: 4488-95.
197. Gallina G, Dolcetti L, Serafini P, Santo CD, Marigo I, Colombo MP, Basso G,
Brombacher F, Borrello I, Zanovello P, Bicciato S, Bronte V. (2006). Tumors induce
a subset of inflammatory monocytes with immunosuppressive activity on CD8 T
cells. J Clin Invest. 116: 2777-90.
198. Chiodoni C., Iezzi M., Guiducci C., Sangaletti S., Alessandrini I., Ratti C., Tiboni F.,
Musiani P., Granger N.D. and Colombo M.P. (2006). Triggereing CD40 on
endothelial cells contributes to tumor growth. J. Exp. Med. 203:2441-50.
199. Saccani A, Schioppa T, Porta C, Biswas SK, Nebuloni M, Vago L, Bottazzi B,
Colombo MP, Mantovani A, Sica A. (2006) p50 nuclear factor-kappaB
overexpression in tumor-associated macrophages inhibits M1 inflammatory
responses and antitumor resistance. Cancer Res. 166:11432-40
200. Gabrilovich DI, Bronte V, Chen SH, Colombo MP, Ochoa A, Ostrand-Rosenberg S,
Schreiber H. (2007). The terminology issue for myeloid-derived suppressor cells.
Cancer Res. 67:425
201. Curti, A., Pandolfi, S., Valzasina, B., Aluigi, M., Isidori, A., Ferri, E., Salvestrini,
V., Bonanno, G., Rutella, S., Durelli, I., Horenstein, A. L., Fiore, F., Massaia, M.,
Colombo, M. P., Baccarani, M., Lemoli, R. M. (2007). Modulation of tryptophan
catabolism by human leukemic cells results in the conversion of CD25- into CD25+
T regulatory cells. Blood 109: 2871-2877.
202. Parmiani G, Castelli C, Pilla L, Santinami M, Colombo MP, Rivoltini L. (2007).
Opposite immune functions of GM-CSF administered as vaccine adjuvant in cancer
patients. Ann Oncol. 18:226-32.
203. Colombo M. P. and Piconese S. (2007). Regulatory T cells inhibition versus
depletion: the right choice in cancer immunotherapy. Nature Rev. Cancer, 7: 880-
887.
204. Melani C., S. Sangaletti, F. M. Barazzetta, Z. Werb and M. P. Colombo. (2007).
Amino biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow
axis responsible for myeloid-derived suppressor cell expansion and macrophage
infiltration in tumor stroma. Cancer Res., 67: 11438-11446
205. Cantiani L., Manara M. C., Zucchini C. , De Sanctis P., Zuntini M., Valvassori L.,
Serra M., Olivero M., Di Renzo M. F., Colombo M. P., Picci P., and K. Scotlandi K..
(2007). Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity
and Met Signaling. Cancer Res. 67:7675-7685.
206. Maio M, Nicolay HJ, Ascierto P, Belardelli F, Camerini R, Colombo M.P., Queirolo
P, Ridolfi R, Russo V, Anzalone L, Fonsatti E, Parmiani G. (2008) The Italian
 Network for Tumor Biotherapy (NIBIT): getting together to push the field forward. J
Transl Med. 12:6-8 IF 2,94
207. Rotta G., Matteoli G., Nuciforo P., Colombo M. P. and Rescigno M. (2008).
Contrasting role of SPARC-related granulomatous reaction in bacterial containment
and induction of immune response. J. Exp. Med. 205: 657-67 IF 14.484
208. Felicetti F., Errico M. C., Bottero L., Segnalino P., Stoppacciaro A., Biffoni M., Felli
N., Mattia G., Pettini M., Colombo M. P., Peschle C. and Carè A. (2008). The PLZF-
microRNA-221/-222 pathway controls melanoma progression through multiple
oncogenic mechanisms. Cancer Res. 68: 2745-54 IF 7,656
209. Piconese S., Valzasina B., and Colombo M. P. (2008). OX40 triggering rescue
tumor-infiltrating dendritic cells functions by blocking regulatory T cells
suppression. J. Exp. Med. 205: 825-39 IF 14.484
210. Sangaletti S., Colombo M.P. (2008) Matricellular proteins at the crossroad of
inflammation and cancer. Cancer Lett. 267: 245-253
211. Sangaletti S.. Di Carlo E., Gariboldi S., Miotti S., Cappetti B., Parenza M., Brekken
R.A., Chiodoni C., Colombo M.P. (2008) Macrophage-derived SPARC bridges
tumor cell-extracellular matrix interactions toward metastasis. Cancer Res
168:9050-9. IF 7,656
212. Gri G., Piconese S., Frossi B., Manfroi V., Merluzzi S., Tripodo C., Viola A., Odom
Sandra., Rivera J., Colombo M.P., Pucillo C.E. (2008) CD4+CD25+ regulatory cells
suppress mast cell degranulation and allergic responses through OX40-OX40L
interaction. Immunity 29: 771-81. IF 18.306
213. Colombo MP, Piconese S. (2009) Polyps wrap mast cells and Treg within
tumorigenic tentacles. Cancer Res. 69:5619-22.
214. Piconese S, Gri G, Tripodo C, Musio S, Gorzanelli A, Frossi B, Pedotti R, Pucillo
CE, Colombo MP. (2009) Mast cells counteract regulatory T-cell suppression
through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation.
Blood. 114:2639-48.
215. Piconese S, Pittoni P, Burocchi A, Gorzanelli A, Carè A, Tripodo C and Colombo
MP. Tumor-intrinsic and –extrinsic roles of c-Kit: mast cells as the primary off-
target of tyrosine kinase inhibitors. A non-redundant role of OX40 in the competitive
fitness of regulatory T cells in response to IL-2. European Journal of Immunology
2010. 40: 2902–2913
216. Guiducci C, Tripodo C, Gong M, Sangaletti S, Colombo MP, Coffman RL, Barrat FJ
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell
activation by nucleic acids via TLR7 and TLR9. J Exp Med. 2010 207:2931-42.
217. Di Sabatino A, Biancheri P, Piconese S, Rosado MM, Ardizzone S, Rovedatti L,
Ubezio C, Massari A, Sampietro GM, Foschi D, Porro GB, Colombo MP, Carsetti R,
MacDonald TT, Corazza GR Peripheral regulatory T cells and serum transforming
growth factor-β: relationship with clinical response to infliximab in Crohn's disease..
Inflamm Bowel Dis. 2010 16:1891-7.
218. Tripodo C, Gri G, Piccaluga P, Frossi B, Guarnotta C, Piconese S, Franco, C. Vetri,
C. E. Pucillo, A. M. Florena, M.P. Colombo abd S. A. Pileri. Mast cells and Th17
cells contribute to the lymphoma-associated pro-inflammatory microenvironment of
angioimmunoblastic T-cell lymphoma. The American Journal of Pathology 2010
177:792-802
219. Sangaletti S, Tripodo C. Ratti C., Piconese S, Porcasi R, Salcedo R., Trinchieri G,
Colombo MP and Chiodoni C.. (2010) Oncogene-driven intrinsic inflammation
 induces leukocyte production of tumor necrosis factor that critically contributes to
mammary carcinogenesis Cancer Research 70:7764-75
220. Zappasodi R, Pupa SM, Ghedini GC, Bongarzone I, Magni M, Cabras AD, Colombo
MP, Carlo-Stella C, Gianni AM, Di Nicola Improved clinical outcome in indolent
B-cell lymphoma patients vaccinated with autologous tumor cells experiencing
immunogenic death.. Cancer Res. 2010 70:9062-72.
221. Meynet O, Scotlandi K, Pradelli E, Manara MC, Colombo MP, Schmid-Antomarchi
H, Picci P, Bernard A, Bernard G Xg expression in Ewing's sarcoma is of
prognostic value and contributes to tumor invasiveness.. Cancer Res. 2010 70:3730-
8.
222. Chiodoni C, Colombo MP, Sangaletti S. Matricellular proteins: from homeostasis to
inflammation, cancer, and metastasis. Cancer Metastasis Rev. 2010 29: 295-307.
223. Maio M, Nicolay HJ, Ascierto PA, Belardelli F, Camerini R, Colombo MP, Queirolo
P, Ridolfi R, Russo V, Fonsatti E, Parmiani G; Seventh annual meeting of the Italian
Network for Tumor Biotherapy (NIBIT), Siena, 1-3 October 2009. NIBIT. Cancer
Immunol Immunother. 2010
224. Rocchi A, Manara MC, Sciandra M, Zambelli D, Nardi F, Nicoletti G, Garofalo C,
Meschini S, Astolfi A, Colombo MP, Lessnick SL, Picci P, Scotlandi K CD99
inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes
to oncogenesis.. J Clin Invest. 2010 120:668-80.
225. Mattia G, Errico MC, Felicetti F, Petrini M, Bottero L, Tomasello L, Romania P,
Boe A, Segnalini P, Di Virgilio A, Colombo MP, Carè A. Constitutive activation of
the ETS-1-miR-222 circuitry in metastatic melanoma. Pigment Cell Melanoma Res.
2011 Jun 28 [Epub ahead of print]
226. Tripodo C, Sangaletti S, Piccaluga PP, Prakash S, Franco G, Borrello I, Orazi A,
Colombo MP, Pileri SA. The bone marrow stroma in hematological neoplasms-a
guilty bystander. Nat Rev Clin Oncol. 8: 456-66.
227. TripodoC, Petta S, Guarnotta C, Pipitone R, Cabibi D, Colombo MP, Craxi A. Liver
Follicular helper T-Cells predict the achievemente of virological response following
IFN-based treatment in HCV genotype-1 chronically infected patients Antiviral
Therapy 52: 673-673
228. Maio M, Nicolay HJ, Ascierto PA, Belardelli F, Camerini R, Colombo MP, Queirolo
P, Ridolfi R, Russo V, Fonsatti E; NIBIT, Parmiani G. Eighth annual meeting of the
Italian network for tumor biotherapy (NIBIT), Siena, October 7-9, 2010. Cancer
Immunol Immunother. 60:901-7.
229. Piconese S, Costanza M, Musio S, Tripodo C, Poliani PL, Gri G, Burocchi A, Pittoni
P, Gorzanelli A, Colombo MP, Pedotti R. Exacerbated experimental autoimmune
encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice. Lab Invest. 91:627-
41.
230. Pittoni P, Piconese S, Tripodo C, Colombo MP. Tumor-intrinsic and –extrinsic roles
of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors. Oncogene.
30:757-69
231. Piconese S., Costanza M., Tripodo C., Sangaletti S., Musio S., Pittoni P., Poliani
PL., Burocchi A., Passafaro AL., Gorzanelli A., Vitali C., Chiodoni C., Barnaba V.,
Pedotti R., Colombo MP. The Matricellular Protein SPARC Supports Follicular
Dendritic Cell Networking Toward Th17 Responses. J. Autoimmunity, in press
232. Pittoni P., Tripodo C., Piconese S., Mauri G., Parenza M., Rigoni A.,Sangaletti S.,
Colombo M.P. Mast cell targeting hampers prostate adenocarcinoma development
 but promotes the occurrence of highly malignant neuroendocrine cancers. Cancer
Res. In press
233.