Você está na página 1de 11

Recomendacionesparaayudaradejardefumaralpacientecardiolgicoentresminutos. ElaboradoporelGrupodeTrabajodetabacodelaSociedadEspaoladeCardiologa,Seccin deCardiologaPreventivayRehabilitacin.

27deMarzode2011 Jaime Fernndez de Bobadilla, Regina Dalmau, Jos Antonio Casasnovas, Manuel Abeytua, Javier Balaguer, Ramn Bover, Jos Antonio Carbonell, Leticia Fernndez, Ramn Fito, Juana Freire,ngelGarca,MarcosGarca,JosMaraGarciadeAndoain,XavierGarcaMoll,Vctor JosepGirbes,LuisGonzlez,CatherineGraupner,EstebanLpezdeS,SusanaMartnez,Juan Morales, Marco Antonio Paz, Francisco Roncales, Juan Carlos Sevilla, Juana Umaran, Juan CarlosYez. Introduccinyobjetivosdeldocumento Aunque los cardilogos seamos conscientes de la importancia terica del tabaquismo, pocas vecesemprendemosaccionesconcretasenlaprcticaclnicaparatratarlodeformaeficaz.No soloenEspaa,tambinenlamayoradelospasesdenuestroentorno.Lafaltadeinterspor el tabaquismo puede estar en relacin con el atractivo tcnico y cientfico de los procedimientos de alta tecnologa utilizados en cardiologa, con la limitada formacin en tabaquismodeloscardilogos,conlalimitacinderecursoshumanosyfinancierosdedicados aestereayconlapercepcindequeelfumadoresenparteresponsabledesuenfermedad. Laausenciadefinanciacindelosmedicamentosparadejardefumarreflejaeldesintersde laAdministracin,poreltratamientodeltabaquismo.Porltimo,elcardilogoyelmdicoen generalvivenlarecadacomounfracaso,queresultadesmotivadorparafuturostratamientos. El objetivo de este documento es suministrar una directriz muy simple con los mnimos necesarios para ayudar a dejar de fumar a nuestros pacientes, con idea de promover un abordajesistemticodeltabaquismoencardiologa.El90%delosconsumidoresregularesde tabacosonadictosalanicotina,unadelasdrogasconmscapacidaddegeneraradiccin.Esto convierteeltabaquismoenunfactorderiesgocardiovasculardetratamientomuycomplejo.El diagnsticoytratamientoptimoestfueradenuestroalcance,dadalaaltaprevalencia.Pero estonopuedeserunaexcusaparadejardetratarunfactorderiesgocardiovascularquees, adems,laprimeracausademuerteevitableennuestroentorno. Lamayoraestamosdeacuerdoenqueeltabaquismoesunaadiccingravecuyotratamiento ptimo requiere la mayora de las veces un abordaje complejo y multidisciplinar. Como este abordajeidealesimposibleypuedeconduciralaconclusinequivocadadequenosepuede hacernada,enlaprctica,resultamuchomsoperativoconsiderarlounfactorderiesgocomo cualquier otro y dedicarle al menos el mismo tiempo que dedicamos al tratamiento de la hipertensin arterial, la dislipemia y la diabetes. Hay extensa evidencia cientfica que demuestra que el consejo breve 1, y la utilizacin de medicamentos, consiguen ndices de abstinenciamuchomsaltosquelosintentosdedejardefumarsinayuda.

El objetivo de este documento es que los cardilogos dediquemos de forma sistemtica y eficiente 3 minutos de nuestro tiempo a ayudar a dejar de fumar a nuestros pacientes cardiovasculares. Si pasamos de la casi completa pasividad actual a dedicar 3 minutos de tiempo bien aprovechados y articulamos mecanismos para un seguimiento aceptable del tratamientofarmacolgico,habremosdadounpasoimportanteenelmanejodeestefactorde riesgocardiovascular. A continuacin exponemos una estrategia de tratamiento sencilla que consumira, una vez automatizada, apenas 3 minutos de tiempo por cada fumador. No aspiramos a que sea la estrategiamseficazperoslamseficienteteniendoencuentalosrecursosdisponibles. Distinguimosdostiposdepacientes:eldeconsultaexternayelpacientehospitalizado. Elaboracindeldocumento. Este documento se ha elaborado partiendo de un texto que fue discutido en la reunin del grupo de trabajo de tabaco que tuvo lugar el da 10 de marzo de 2011 en la Sede de la Sociedad Espaola de Cardiologa. Como resultado de la discusin se elabor un documento quefuemodificadohastaobtenerunaversinfinalconsensuada. TodoslosmiembrosdelgrupodetrabajodetabacodelaSECyladirectivadelaSeccinde Cardiologa Preventiva y Rehabilitacin fueron informados del proyecto e invitados a participar. Usodeldocumento. El documento incluye un Mensaje Verbal estndar con una serie de ideas que el cardilogo deberaintentartransmitiralpacientefumador.Cadaprofesionalutilizarsupropiolenguajey adaptar el mensaje a cada circunstancia. En segundo lugar, una Hoja de Seguimiento/Texto para el Informe de Alta diseada para potenciar el esfuerzo realizado por el clnico. Existe evidencia cientfica que demuestra que el seguimiento del paciente aumenta significativamente la abstinencia continuada al ao 2. Por ltimo, se facilitar al paciente MaterialdeApoyoImpreso,quedeberasersuficientementeclaro,comoparaqueelpaciente promediopuedayquieraleerloyasimilarlo.Ademsselefacilitarladireccindelapgina web de la Sociedad Espaola de Cardiologa para que pueda acceder a material extra disponibleenlaweb. MensajeVerbalparaelpaciente La estrategia para el paciente hospitalizado es similar a la de la consulta, con los siguientes matices: a) La mayora de los pacientes consideran que ya han dejado de fumar, por lo que, asumiremosquelafechaparadejardefumaryahapasado,lesfelicitaremosporsudecisiny

reforzaremossudeterminacindenovolverafumarcuandosalgadelhospitalb)Lahojade seguimientosesustituir(siesposible)poruntextoenelinformedealta. Sepresentaacontinuacinlaestrategiaestndarparaelpacienteenconsultasdiseadapara hacerseen3minutos. 1) Fumaygradodedependencia?Formulamos3preguntassencillas: a. Fuma? b. Desdecundo,cuntoycundofumaelprimercigarrillodelda? c. Haintentadodejardefumarantesycuntotiempoestuvosinfumar? 2) Quieredejardefumar? Aunque el paciente diga que quiere dejar de fumar, daremos el consejo estndar para reafirmar su decisin. Es importante, informar, empatizar y motivar y evitar reir al paciente. A continuacin los mensajes que recomendamos que se incluyan en la conversacinconelpaciente: Lomsimportantequepuedehacerporsusalud:msquelascosasquelehemoshecho enelhospitalolasmedicinasqueesttomando. Dejardefumaresposible:muchagenteloconsigue Consecuenciassisiguefumando:laprobabilidaddemorirenlosprximos2aoses12%. Beneficiossilodejaahora:laprobabilidaddeseguirvivodentrode2aosescasiladeun no fumador: 98% 3. Adems, evitar cncer, enfermedad pulmonar grave y tendr ms capacidad para hacer las cosas que le gustan y ejercicio fsico y una vida sexual ms satisfactoria4.Sesentirmsjoven:suorganismorejuvenecerenmuchosaspectos. Reducirelconsumonoessuficiente.Lanicotinaesunadrogaylamayoradelasveceshay que elegir todo o nada. Es difcil mantener una disminucin del consumo y, adems, consumosdeunsolocigarrillo/dasonmuynegativosparalasaluddesucorazn5.
Si le paciente no quiere dejar de fumar: Le damos el consejo estndar, le suministramos materialyleinvitamosaquereconsideresudecisinyaque,almenos,intentereducirel consumocomopuenteadejarlodefinitivamente. Pacientesconintentosfallidosprevios:Enlospacientesrefractarios,enlosquehahabido intentos fallidos, adems de dar todos los pasos previos detallados ms arriba y pautar tratamiento farmacolgico, si tenemos acceso a unaunidad de tabaquismo especializada sinlistadeesperaimportante,loremitiremosadichaunidad.

3) Cmovoyaayudarleaquedejedefumar? Fijemoshoymismounafechaydgaleatodosquevaadejardefumar Evitesituacionesderiesgoyelimineelementosdetuentorno. Cuandosientasdeseosdefumar,debesaberquepasarn,nodniunasolacalada Nuncapiensequecontrolaeltabaco:eltabacoesunadrogaysivuelveafumarunsolo cigarrillo,esmuyprobablequeenpocotiempoestfumandocomoantes. Nodejequeotrosfumenentucasaoentutrabajo,elhumoperjudicasusalud.

4) Prescribirmedicacin Esimportantequeusemoslosmedicamentosquemultiplicanlaprobabilidaddequedeje defumar,mejorandomuchosusexpectativas.Quizahoracreaquepuedesolo,perolos estudiosdemuestranqueconmedicamentoslaprobabilidaddexitoseduplicaotriplica2. Enestemomento,losmedicamentosnoestnfinanciados,peronopiensequesoncaros. Haga cuentas de lo que gasta en tabaco y de la cantidad de dinero que ahorrar en los prximosaosdejandodefumar6. El cardilogo puede prescribir el medicamento ms oportuno en cada caso, teniendo en cuentaque: Las guas internacionales recomiendan medicacin a todos los pacientes 2 y que existentresmedicamentosqueseconsiderandeprimeraeleccin:Vareniclina,Terapia SustitutivadeNicotinayBupropion7. Vareniclinaeselmedicamentomseficazenensayosclnicosenpoblacingeneral8. Vareniclina, en metanlisis y ensayos head to head es ms eficaz que Bupropion y queParchesdenicotina9. Vareniclinaeselmedicamentoconmsevidenciaencardiopataisqumica10. Sielpacientehatenidounintentoprevioexitoso(lograbstinenciacontinuadurante1 ao):considerarrepetirlaopcinutilizada. 5) Seguimiento Unodelosproblemasprincipalesparalospacienteseselseguimiento.Loidealesqueel primerseguimientoserealiceelprimermesdespusdelalta.Aprovecharemoslaocasin paraintentarestablecerunespaciolibredehumoenlaviviendadelpacientequeayudar alpacienteadejardefumary,adems,disminuirsuriesgodeeventos. El modelo de carta para suministrar al paciente, dirigido a su mdico de AP, cuando el pacienteestsiendovistoenconsultaseselsiguiente: Estimadocolega,Elpaciente___________________________________________________ condiagnsticode___________________________________________________________ Fumadorde___paquetesaldadesdehace___aosyquefumaelprimercigarrilloalas ______horasdelevantarse,haestablecidolasiguientefechaparadejardefumar_______ yestrecibiendotratamientocon___________desdeelda___________adosisde____ Teruegoque,enlamedidadeloposible,realiceselseguimientodelpacientedentrode2 y 12 semanas para su seguimiento. Es importante para la salud del paciente que sus familiares,amigosycompaerosnofumenensuentorno,yaqueelhumodeloscigarrillos inhaladodeformapasivaaumentaelriesgodeunnuevoepisodiocardiovascular11. Cuando el paciente est hospitalizado, si es posible, aadiremos al informe de alta, el siguientetexto: El paciente, fumador de ___ paquetes al da desde hace___ aos y que fuma el primer cigarrilloalas______horasdelevantarse,hadejadodefumareldadesuingresoenel hospital,yestrecibiendotratamientocon___________adosisde_________________ Teruegoque,enlamedidadeloposible,realiceselseguimientodelpacientedentrode2 y 12 semanas para su seguimiento. Es importante que sus familiares, amigos y

compaerosnofumenensuentorno,yaqueelhumodeloscigarrillosinhaladodeforma pasivaaumentaelriesgodeunnuevoepisodiocardiovascular. 6) Materialdeayuda Materialparasuministrarapacientes Pendientedeelaborar MaterialenlapginawebdelaSEC: Calculadora de costes: http://www.fundaciondelcorazon.com/informacionpara pacientes/prevencionsecundaria/calculadoratabaco.html Materialpendientedeelaborareinsertar Referenciasdepublicaciones:guas,ensayos,estudiosdecosteefectividad 7) Siguientespasoseideasparamejorar Elaborarprogramadeseguimientoymotivacinatravsdecorreoelectrnico. Invitaralaenfermeracardiovascularalasprximasreunionesdelgrupo. Aumentarladisponibilidadyelusodecooxmetrosenlasconsultas. Referencias
1

Metaanalysis(1996):Effectivenessofandestimatedabstinenceratesforadvicetoquitbyaphysician (n=7studies)FioreMC,JaenCR,BakerTBetal.Treatingtobaccouseanddependence:2008.Rockville: US Department of Health and Human Services. 2008. Disponible en http://ww.ahrq.gov/path/tobacco.htm#Clinic.
DemersRY,NealeAV,AdamsR,etal.Theimpactofphysicians'briefsmokingcessationcounseling:aMIRNETstudy.JFam Pract1990;31(6):6259. JamrozikK,VesseyM,FowlerG,etal.Controlledtrialofthreedifferentantismokinginterventionsingeneralpractice.BrMed J1984;288(6429):14991503. PageAR,WaltersDJ,SchlegelRP,etal.Smokingcessationinfamilypractice:theeffectsofadviceandnicotinechewinggum prescription.AddictBehav1986;11(4):4436. RussellMA,WilsonC,TaylorC,etal.Effectofgeneralpractitioners'adviceagainstsmoking.BrMedJ1979;2(6184):2315. RussellMAH,MerrimanR,StapletonJ,etal.Effectofnicotinechewinggumasanadjuncttogeneralpractitioners'advice againstsmoking.BrMedJ1983;287(6407):17825. SlamaK,RedmanS,PerkinsJ,etal.Theeffectivenessoftwosmokingcessationprogrammesforuseingeneralpractice:a randomisedclinicaltrial.BrMedJ1990;300(6741):17079. Stewart PJ, Rosser WW. The impact of routine advice on smoking cessation from family physicians. Can Med Assoc J 1982;126(9):10514.

Fiore MC, Jaen CR, Baker TB et al. Treating tobacco use and dependence: 2008. Rockville: US Department of Health and Human Services. 2008. Disponible en http://ww.ahrq.gov/path/tobacco.htm#Clinic. 3SyedM.Mohiuddin,MD,FCCP,AryanN.Mooss,MD,FCCP,ClaireB.Hunter,MD,TimothyL.Grollmes, MPA,DavidA.Cloutier,BS,andDanielE.Hilleman,PharmDIntensiveSmokingCessationIntervention ReducesMortalityinHighRiskSmokersWithCardiovascularDisease*cHESTFebruary2007vol.131no. 2446452 4 FordES,AjaniUA,CroftJB,etal.ExplainingthedecreaseinU.S.deathsfromcoronarydisease,1980 2000.NEnglJMed2007,356:238898.


5 Harriete, VanSpall, Alice Chong, Jack V Tu. Inpatient smokingcessation counseling and allcause mortality in patients with acute myocardial infarction. American Heart Journal Volume154,Issue2,Pages213220,August2007 6 Sloan FA, Ostermann J, Picone G. The price of smoking. Cambridge, MA, Massachusetts Institute of Technology,2004.

Metaanalysis(2008):Effectivenessandabstinenceratesofmedicationsrelativetothenicotinepatch (n=86studies) Fiore MC, Jaen CR, Baker TB et al. Treating tobacco use and dependence: 2008. Rockville: US Department of Health and Human Services. 2008. Disponible en http:// www.ahrq.gov/path/tobacco.htm#Clinic.
Abelin T, Buehler A, Muller P, et al. Controlled trial of transdermal nicotine patch in tobacco withdrawal. Lancet 1989;1:710. Ahluwalia JS, Harris KJ, Catley D, et al. Sustainedrelease bupropion for smoking cessation in African Americans: a randomizedcontrolledtrial.JAMA2002;288:46874. Ahluwalia JS, Okuyemi K, Nollen N, et al. The effects of nicotine gum and counseling among African American light smokers:a2x2factorialdesign.Addiction2006;101:88391. Ahluwalia JS, McNagny SE, Clark WS. Smoking cessation among innercity African Americans using the nicotine transdermalpatch.JGenInternMed1998;13:18. Ahmadi J, Ashkani H, Ahmadi M, et al. Twentyfour week maintenance treatment of cigarette smoking with nicotine gum,clonidineandnaltrexone.JSubstAbuseTreat2003;24:2515. AreechonW,PunnotokJ.Smokingcessationthroughtheuseofnicotinechewinggum:adoubleblindtrialinThailand. ClinTher1988;10:1836. AubinHJ,LebargyF,BerlinI,etal.EfficacyofbupropionandpredictorsofsuccessfuloutcomeinasampleofFrench smokers:arandomizedplacebocontrolledtrial.Addiction2004;99:120618. Blondal T, Gudmundsson LJ, Olafsdottir I, et al. Nicotine nasal spray with nicotine patch for smoking cessation: randomisedtrialwithsixyearfollowup.BrMedJ1999;318:2858. BohadanaA,NilssonF,RasmussenT,etal.Nicotineinhalerandnicotinepatchasacombinationtherapyforsmoking cessation:arandomized,doubleblind,placebocontrolledtrial.ArchInternMed2000;160:312834. CinciripiniPM,TsohJY,WetterDW,etal.Combinedeffectsofvenlafaxine,nicotinereplacement,andbriefcounseling onsmokingcessation.ExpClinPsychopharmacol2005;13:28292. Collins BN, Wileyto EP, Patterson F, et al. Gender differences in smoking cessation in a placebocontrolled trial of bupropionwithbehavioralcounseling.NicotineTobRes2004;6:2737. CooperTV,KlesgesRC,DebonMW,etal.Aplacebocontrolledrandomizedtrialoftheeffectsofphenylpropanolamine andnicotinegumoncessationratesandpostcessationweightgaininwomen.AddictBehav2005;30:6175. CoveyLS,GlassmanAH,StetnerF,etal.Arandomizedtrialofsertralineasacessationaidforsmokerswithahistoryof majordepression.AmJPsychiatry2002;159:17317. CroghanGA,SloanJA,CroghanIT,etal.Comparisonofnicotinepatchaloneversusnicotinenasalsprayaloneversusa combination for treating smokers: a minimal intervention, randomized multicenter trial in a nonspecialized setting. NicotineTobRes2003;5:1817. da Costa CL, Younes RN, Lourenco MT. Stopping smoking: a prospective, randomized, doubleblind study comparing nortriptylinetoplacebo.Chest2002;122:4038. Dalsgareth OJ, Hansen NC, SoesPetersen U, et al. A multicenter, randomized, doubleblind, placebocontrolled, 6 monthtrialofbupropionhydrochloridesustainedreleasetabletsasanaidtosmokingcessationinhospitalemployees. NicotineTobRes2004;6:5561. Daughton D, Susman J, Sitorius M, et al. Transdermal nicotine therapy and primary care. Importance of counseling, demographic,andparticipantselectionfactorson1yearquitrates.TheNebraskaprimarypracticesmokingcessation trialgroup.ArchFamMed1998;7:42530. DavidsonM,EpsteinM,BurtR,etal.Efficacyandsafetyofanoverthecountertransdermalnicotinepatchasanaidfor smokingcessation.ArchFamMed1998;7:56974. Evins AE, Cather C, Deckersbach T, et al. A doubleblind placebocontrolled trial of bupropion sustainedrelease for smokingcessationinschizophrenia.JClinPsychopharmacol2005;25:21825. Evins AE, Mays VK, Rigotti NA, et al. A pilot trial of bupropion added to cognitive behavioral therapy for smoking cessationinschizophrenia.NicotineTobRes2001;3:397403. Fee WM, Stewart MJ. A controlled trial of nicotine chewing gum in a smoking withdrawal clinic. Practitioner 1982;226:148151. *FioreMC,KenfordSL,JorenbyDE,etal.Twostudiesoftheclinicaleffectivenessofthenicotinepatchwithdifferent counselingtreatments.Chest1994;105:52433. FortmannSP,KillenJD,TelchMJ,etal.Minimalcontacttreatmentforsmokingcessation.Aplacebocontrolledtrialof nicotine polacrilex and selfdirected relapse prevention: initial results of the Stanford stop smoking project. JAMA 1988;260:157580. George TP, Vessicchio JC, Termine A, et al. A placebo controlled trial of bupropion for smoking cessation in schizophrenia.BiolPsychiatry2002;52:5361.


GlassmanAH,CoveyLS,DalackGW,etal.Smokingcessation,clonidine,andvulnerabilitytonicotineamongdependent smokers.ClinPharmacolTher1993;54:6709. GlassmanAH,StetnerF, WalshBT, etal.Heavysmokers,smokingcessation,andclonidine:resultsofadoubleblind, randomizedtrial.JAMA1988;259:28636. GonzalesD,RennardSI,NidesM,etal.Varenicline,analpha4beta2nicotinicacetylcholinereceptorpartialagonist,vs sustainedreleasebupropionandplaceboforsmokingcessation:arandomizedcontrolledtrial.JAMA2006;296:4755. GonzalesDH,NidesMA,FerryLH,etal.BupropionSRasanaidtosmokingcessationinsmokerstreatedpreviouslywith bupropion:arandomizedplacebocontrolledstudy.ClinPharmacolTher2001;69:43844. GourlaySG,ForbesA,MarrinerT,etal.Doubleblindtrialofrepeatedtreatmentwithtransdermalnicotineforrelapsed smokers.BrMedJ1995;311:3636. HaggstramFM,ChatkinJM,SussenbachVazE,etal.Acontrolledtrialofnortriptyline,sustainedreleasebupropionand placeboforsmokingcessation:preliminaryresults.PulmPharmacolTher2006;19:2059. HallSM,HumfleetGL,Reus VI,etal.Extendednortriptylineandpsychologicaltreatmentforcigarettesmoking.AmJ Psychiatry2004;161:21007. Hall SM, Humfleet GL, Reus VI, et al. Psychological intervention and antidepressant treatment in smoking cessation. ArchGenPsychiatry2002;59:9306. HallSM,MunozRF,ReusVI,etal.Moodmanagementandnicotineguminsmokingtreatment:atherapeuticcontact andplacebocontrolledstudy.JConsultClinPsychol1996;64:10039. HallSM,TunstallCD,GinsbergD,etal.Nicotinegumandbehavioraltreatment:aplacebocontrolledtrial.JConsultClin Psychol1987;55:6035. HaysJT,CroghanIT,SchroederDR,etal.Overthecounternicotinepatchtherapyforsmokingcessation:resultsfrom randomized,doubleblind,placebocontrolled,andopenlabeltrials.AmJPublicHealth1999;89:17017. Herrera N, Franco R, Herrera L, et al. Nicotine gum, 2 and 4 mg, for nicotine dependence. A doubleblind placebo controlledtrialwithinabehaviormodificationsupportprogram.Chest1995;108:44751. HjalmarsonA,FranzonM,WestinA,etal.Effectofnicotinenasalsprayonsmokingcessation.Arandomized,placebo controlled,doubleblindstudy.ArchInternMed1994;154:256772. HjalmarsonA,NilssonF,SjostromL,etal.Thenicotineinhalerinsmokingcessation.ArchInternMed1997;157:17218. HoltS,TimuParataC,RyderLewisS,etal.EfficacyofbupropionintheindigenousMaoripopulationinNewZealand. Thorax2005;60:1203. Hughes JR, Lesmes GR, Hatsukami DK, et al. Are higher doses of nicotine replacement more effective for smoking cessation?NicotineTobRes1999;1:16974. HughesJR,NovyP,HatsukamiDK,etal.Efficacyofnicotinepatchinsmokerswithahistoryofalcoholism.AlcoholClin ExpRes2003;27:94654. HurtRD,DaleLC,FredricksonPA,etal.Nicotinepatchtherapyforsmokingcessationcombinedwithphysicianadvice andnursefollowup.Oneyearoutcomeandpercentageofnicotinereplacement.JAMA1994;271:595600. HurtRD,SachsDP,GloverED,etal.Acomparisonofsustainedreleasebupropionandplaceboforsmokingcessation.N EnglJMed1997;337:1195202. JensenEJ,SchmidtE,PedersenB,etal.Theeffectofnicotine,silveracetate,andplacebochewinggumonthecessation ofsmoking.Theinfluenceofsmokingtypeandnicotinedependence.IntJAddict1991;26:122331. Jorenby DE, Hays JT, Rigotti NA, et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustainedrelease bupropion for smoking cessation: a randomized controlled trial. JAMA 2006;296:5663. JorenbyDE,LeischowSJ,NidesMA,etal.Acontrolledtrialofsustainedreleasebupropion,anicotinepatch,orbothfor smokingcessation.NEnglJMed1999;340:68591. JosephAM,NormanSM,FerryLH,etal.Thesafetyoftransdermalnicotineasanaidtosmokingcessationinpatients withcardiacdisease.NEnglJMed1996;335:17928. KillenJD,FortmannSP,DavisL,etal.Nicotinepatchandselfhelpvideoforcigarettesmokingcessation.JConsultClin Psychol1997;65:66372. KillenJD,FortmannSP,MurphyJrGM,etal.ExtendedtreatmentwithbupropionSRforcigarettesmokingcessation.J ConsultClinPsychol2006;74:28694. KillenJD,FortmannSP,NewmanB,etal.Evaluationofatreatmentapproachcombiningnicotinegumwithselfguided behavioraltreatmentsforsmokingrelapseprevention.JConsultClinPsychol1990;58:8592. KillenJD,FortmannSP,SchatzbergAF,etal.Nicotinepatchandparoxetineforsmokingcessation.JConsultClinPsychol 2000;68:8839. KornitzerM,BoutsenM,DramaixM,etal.Combineduseofnicotinepatchandguminsmokingcessation:aplacebo controlledclinicaltrial.PrevMed1995;24:417. LeischowSJ,NilssonF,FranzonM,etal.Efficacyofthenicotineinhalerasanadjuncttosmokingcessation.AmJHealth Behav1996;20(5):36471. LewisSF,PiaseckiTM,FioreMC,etal.Transdermalnicotinereplacementforhospitalizedpatients:arandomizedclinical trial.PrevMed1998;27:296303. MylesPS,LeslieK,AnglissM,etal.Effectivenessofbupropionasanaidtostoppingsmokingbeforeelectivesurgery:a randomisedcontrolledtrial.Anaesthesia2004;59:10538. Niaura R, Spring B, Borrelli B, et al. Multicenter trial of fluoxetine as an adjunct to behavioral smoking cessation treatment.JConsultClinPsychol2002;70:88796. Nides M, Oncken C, Gonzales D, et al. Smoking cessation with varenicline, a selective alpha4beta2 nicotinic receptor partialagonist:resultsfroma7week,randomized,placeboandbupropioncontrolledtrialwith1yearfollowup.Arch InternMed2006;166:15618. OnckenC,GonzalesD,NidesM,etal.Efficacyandsafetyofthenovelselectivenicotinicacetylcholinereceptorpartial agonist,varenicline,forsmokingcessation.ArchInternMed2006;166:15717.


PerngRP,HsiehWC,ChenYM,etal.Randomized,doubleblind,placebocontrolledstudyoftransdermalnicotinepatch forsmokingcessation.JFormosMedAssoc1998;97:54751. ProchazkaAV, KickS, SteinbrunnC,etal.Arandomizedtrialofnortriptylinecombined withtransdermalnicotinefor smokingcessation.ArchInternMed2004;164:222933. Puska P, Korhonen HJ, Vartiainen E, et al. Combined use of nicotine patch and gum compared with gum alone in smokingcessationaclinicaltrialinNorthKarelia.TobControl1995;4:2315. RichmondRL,KehoeL,deAlmeidaNetoAC.Effectivenessofa24hourtransdermalnicotinepatchinconjunctionwitha cognitivebehaviouralprogramme:oneyearoutcome.Addiction1997;92:2731. Sachs DP, Sawe U, Leischow SJ. Effectiveness of a 16hour transdermal nicotine patch in a medical practice setting, withoutintensivegroupcounseling.ArchInternMed1993;153:188190. *Schneider NG, Jarvik ME, Forsythe AB, et al. Nicotine gum in smoking cessation: a placebocontrolled, doubleblind trial.AddictBehav1983;8:25361. SchneiderNG,OlmsteadR,ModyFV,etal.Efficacyofanicotinenasalsprayinsmokingcessation:aplacebocontrolled, doubleblindtrial.Addiction1995;90:167182. SchneiderNG,OlmsteadR,NilssonF,etal.Efficacyofanicotineinhalerinsmokingcessation:adoubleblind,placebo controlledtrial.Addiction1996;91:1293306. Simon JA, Duncan C, Carmody TP, et al. Bupropion for smoking cessation: a randomized trial. Arch Intern Med 2004;164:1797803. *Sonderskov J, Olsen J, Sabroe S, et al. Nicotine patches in smoking cessation: a randomized trial among overthe countercustomersinDenmark.AmJEpidemiol1997;145:30918. Stapleton JA, Russell MA, Feyerabend C, et al. Dose effects and predictors of outcome in a randomized trial of transdermalnicotinepatchesingeneralpractice.Addiction1995;90:3142. SutherlandG,StapletonJA,RussellMA,etal.Randomisedcontrolledtrialofnasalnicotinesprayinsmokingcessation. Lancet1992;340:3249. SwansonNA,BurroughsCC,LongMA,etal.ControlledtrialforsmokingcessationinaNavyshipboardpopulationusing nicotinepatch,sustainedreleasebupropion,orboth.MilMed2003;168:8304. Tashkin D, Kanner R, Bailey W, et al. Smoking cessation in patients with chronic obstructive pulmonary disease: a doubleblind,placebocontrolled,randomisedtrial.Lancet2001;357:15715. Tonnesen P, Mikkelsen KL. Smoking cessation with four nicotine replacement regimes in a lung clinic. Eur Respir J 2000;16:71722. Tonnesen P, Norregaard J, Mikkelsen K, et al. A doubleblind trial of a nicotine inhaler for smoking cessation. JAMA 1993;269:126871. TonnesenP,NorregaardJ,SimonsenK,etal.Adoubleblindtrialofa16hourtransdermalnicotinepatchinsmoking cessation.NEnglJMed1991;325:3115. TonnesenP,PaolettiP,GustavssonG,etal.Higherdosagenicotinepatchesincreaseoneyearsmokingcessationrates: resultsfromtheEuropeanCEASEtrial.EurRespirJ1999;13:23846. TonnesenP,TonstadS,HjalmarsonA,etal.Amulticentre,randomized,doubleblind,placebocontrolled,1yearstudy ofbupropionSRforsmokingcessation.JInternMed2003;254:18492. Tonstad S, Farsang C, Klaene G, et al. Bupropion SR for smoking cessation in smokers with cardiovascular disease: a multicentre,randomisedstudy.EurHeartJ2003;24:94655. Transdermal Nicotine Study Group. Transdermal nicotine for smoking cessation. Sixmonth results from two multicentercontrolledclinicaltrials.JAMA1991;266:31338. Wagena EJ, Knipschild PG, Huibers MJ, et al. Efficacy of bupropion and nortriptyline for smoking cessation among peopleatriskfororwithchronicobstructivepulmonarydisease.ArchInternMed2005;165:228692. WestmanEC,LevinED,RoseJE.Thenicotinepatchinsmokingcessation.Arandomizedtrialwithtelephonecounseling. ArchInternMed1993;153:191723. Wong GY, Wolter TD, Croghan GA, et al. A randomized trial of naltrexone for smoking cessation. Addiction 1999;94:122737. ZellwegerJP,BoelcskeiPL,CarrozziL,etal.BupropionSRvsplaceboforsmokingcessationinhealthcareprofessionals. AmJHealthBehav2005;29:2409.
8

Metaanalysis (2008): Effectiveness and abstinence rates for various medications and medication combinationscomparedtoplaceboat6monthspostquit(n=86studies) Fiore MC, Jaen CR, Baker TB et al. Treating tobacco use and dependence: 2008. Rockville: US http:// Department of Health and Human Services. 2008. Disponible en www.ahrq.gov/path/tobacco.htm#Clinic.
Abelin T, Buehler A, Muller P, et al. Controlled trial of transdermal nicotine patch in tobacco withdrawal. Lancet 1989;1:710. Ahluwalia JS, Harris KJ, Catley D, et al. Sustainedrelease bupropion for smoking cessation in African Americans: a randomizedcontrolledtrial.JAMA2002;288:46874. Ahluwalia JS, McNagny SE, Clark WS. Smoking cessation among innercity African Americans using the nicotine transdermalpatch.JGenInternMed1998;13:18. Ahluwalia JS, Okuyemi K, Nollen N, et al. The effects of nicotine gum and counseling among African American light smokers:a2x2factorialdesign.Addiction2006;101:88391. Ahmadi J, Ashkani H, Ahmadi M, et al. Twentyfour week maintenance treatment of cigarette smoking with nicotine gum,clonidineandnaltrexone.JSubstAbuseTreat2003;24:2515.


AreechonW,PunnotokJ.Smokingcessationthroughtheuseofnicotinechewinggum:adoubleblindtrialinThailand. ClinTher1988;10:1836. AubinHJ,LebargyF,BerlinI,etal.EfficacyofbupropionandpredictorsofsuccessfuloutcomeinasampleofFrench smokers:arandomizedplacebocontrolledtrial.Addiction2004;99:120618. Blondal T, Gudmundsson LJ, Olafsdottir I, et al. Nicotine nasal spray with nicotine patch for smoking cessation: randomisedtrialwithsixyearfollowup.BrMedJ1999;318:2858. BohadanaA,NilssonF,RasmussenT,etal.Nicotineinhalerandnicotinepatchasacombinationtherapyforsmoking cessation:arandomized,doubleblind,placebocontrolledtrial.ArchInternMed2000;160:312834. CinciripiniPM,TsohJY,WetterDW,etal.Combinedeffectsofvenlafaxine,nicotinereplacement,andbriefcounseling onsmokingcessation.ExpClinPsychopharmacol2005;13(4):28292. Collins BN, Wileyto EP, Patterson F, et al. Gender differences in smoking cessation in a placebocontrolled trial of bupropionwithbehavioralcounseling.NicotineTobRes2004;6(1):2737. CooperTV,KlesgesRC,DebonMW,etal.Aplacebocontrolledrandomizedtrialoftheeffectsofphenylpropanolamine andnicotinegumoncessationratesandpostcessationweightgaininwomen.AddictBehav2005;30(1):6175. CoveyLS,GlassmanAH,StetnerF,etal.Arandomizedtrialofsertralineasacessationaidforsmokerswithahistoryof majordepression.AmJPsychiatry2002;159:17317. CroghanGA,SloanJA,CroghanIT,etal.Comparisonofnicotinepatchaloneversusnicotinenasalsprayaloneversusa combination for treating smokers: a minimal intervention, randomized multicenter trial in a nonspecialized setting. NicotineTobRes2003;5(2):1817. da Costa CL, Younes RN, Lourenco MT. Stopping smoking: a prospective, randomized, doubleblind study comparing nortriptylinetoplacebo.Chest2002;122:4038. Dalsgareth OJ, Hansen NC, SoesPetersen U, et al. A multicenter, randomized, doubleblind, placebocontrolled, 6 monthtrialofbupropionhydrochloridesustainedreleasetabletsasanaidtosmokingcessationinhospitalemployees. NicotineTobRes2004;6(1):5561. Daughton D, Susman J, Sitorius M, et al. Transdermal nicotine therapy and primary care. Importance of counseling, demographic,andparticipantselectionfactorson1yearquitrates.TheNebraskaprimarypracticesmokingcessation trialgroup.ArchFamMed1998;7(5):42530. DavidsonM,EpsteinM,BurtR,etal.Efficacyandsafetyofanoverthecountertransdermalnicotinepatchasanaidfor smokingcessation.ArchFamMed1998;7:56974. Evins AE, Cather C, Deckersbach T, et al. A doubleblind placebocontrolled trial of bupropion sustainedrelease for smokingcessationinschizophrenia.JClinPsychopharmacol2005;25(3):21825. Evins AE, Mays VK, Rigotti NA, et al. A pilot trial of bupropion added to cognitive behavioral therapy for smoking cessationinschizophrenia.NicotineTobRes2001;3:397403. Fee WM, Stewart MJ. A controlled trial of nicotine chewing gum in a smoking withdrawal clinic. Practitioner 1982;226:148151. *FioreMC,KenfordSL,JorenbyDE,etal.Twostudiesoftheclinicaleffectivenessofthenicotinepatchwithdifferent counselingtreatments.Chest1994;105:52433. FortmannSP,KillenJD,TelchMJ,etal.Minimalcontacttreatmentforsmokingcessation.Aplacebocontrolledtrialof nicotine polacrilex and selfdirected relapse prevention: initial results of the Stanford stop smoking project. JAMA 1988;260(11):157580. George TP, Vessicchio JC, Termine A, et al. A placebo controlled trial of bupropion for smoking cessation in schizophrenia.BiolPsychiatry2002;52:5361. GlassmanAH,CoveyLS,DalackGW,etal.Smokingcessation,clonidine,andvulnerabilitytonicotineamongdependent smokers.ClinPharmacolTher1993;54:6709. GlassmanAH,StetnerF,WalshBT,etal.Heavysmokers,smokingcessation,andclonidine.Resultsofadoubleblind, randomizedtrial.JAMA1988;259:28636. GonzalesD,RennardSI,NidesM,etal.Varenicline,analpha4beta2nicotinicacetylcholinereceptorpartialagonist,vs sustainedreleasebupropionandplaceboforsmokingcessation:arandomizedcontrolledtrial.JAMA2006;296(1):47 55. GonzalesDH,NidesMA,FerryLH,etal.BupropionSRasanaidtosmokingcessationinsmokerstreatedpreviouslywith bupropion:arandomizedplacebocontrolledstudy.ClinPharmacolTher2001;69(6):43844. GourlaySG,ForbesA,MarrinerT,etal.Doubleblindtrialofrepeatedtreatmentwithtransdermalnicotineforrelapsed smokers.BrMedJ1995;311:3636. HaggstramFM,ChatkinJM,SussenbachVazE,etal.Acontrolledtrialofnortriptyline,sustainedreleasebupropionand placeboforsmokingcessation:preliminaryresults.PulmPharmacolTher2006;19:2059. Hall SM, Humfleet GL, Reus VI, et al. Psychological intervention and antidepressant treatment in smoking cessation. ArchGenPsychiatry2002;59:9306. HallSM,HumfleetGL,Reus VI,etal.Extendednortriptylineandpsychologicaltreatmentforcigarettesmoking.AmJ Psychiatry2004;161:21007. HallSM,MunozRF,ReusVI,etal.Moodmanagementandnicotineguminsmokingtreatment:atherapeuticcontact andplacebocontrolledstudy.JConsultClinPsychol1996;64(5):10039. HallSM,TunstallCD,GinsbergD,etal.Nicotinegumandbehavioraltreatment:aplacebocontrolledtrial.JConsultClin Psychol1987;55:6035. HaysJT,CroghanIT,SchroederDR,etal.Overthecounternicotinepatchtherapyforsmokingcessation:resultsfrom randomized,doubleblind,placebocontrolled,andopenlabeltrials.AmJPublicHealth1999;89(11):17017. Herrera N, Franco R, Herrera L, et al. Nicotine gum, 2 and 4 mg, for nicotine dependence. A doubleblind placebo controlledtrialwithinabehaviormodificationsupportprogram.Chest1995;108:44751. HjalmarsonA,FranzonM,WestinA,etal.Effectofnicotinenasalsprayonsmokingcessation.Arandomized,placebo controlled,doubleblindstudy.ArchInternMed1994;154:256772. HjalmarsonA,NilssonF,SjostromL,etal.Thenicotineinhalerinsmokingcessation.ArchInternMed1997;157:17218.


HoltS,TimuParataC,RyderLewisS,etal.EfficacyofbupropionintheindigenousMaoripopulationinNewZealand. Thorax2005;60:1203. Hughes JR, Lesmes GR, Hatsukami DK, et al. Are higher doses of nicotine replacement more effective for smoking cessation?NicotineTobRes1999;1(2):16974. HughesJR,NovyP,HatsukamiDK,etal.Efficacyofnicotinepatchinsmokerswithahistoryofalcoholism.AlcoholClin ExpRes2003;27:94654. HurtRD,DaleLC,FredricksonPA,etal.Nicotinepatchtherapyforsmokingcessationcombinedwithphysicianadvice andnursefollowup.Oneyearoutcomeandpercentageofnicotinereplacement.JAMA1994;271(8):595600. HurtRD,SachsDP,GloverED,etal.Acomparisonofsustainedreleasebupropionandplaceboforsmokingcessation. NewEnglJMed1997;337(17):1195202. JensenEJ,SchmidtE,PedersenB,etal.Theeffectofnicotine,silveracetate,andplacebochewinggumonthecessation ofsmoking.Theinfluenceofsmokingtypeandnicotinedependence.IntJAddict1991;26:122331. Jorenby DE, Hays JT, Rigotti NA, et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustainedrelease bupropion for smoking cessation: a randomized controlled trial. JAMA 2006;296(1):5663. JorenbyDE,LeischowSJ,NidesMA,etal.Acontrolledtrialofsustainedreleasebupropion,anicotinepatch,orbothfor smokingcessation.NewEnglJMed1999;340(9):68591. JosephAM,NormanSM,FerryLH,etal.Thesafetyoftransdermalnicotineasanaidtosmokingcessationinpatients withcardiacdisease.NEnglJMed1996;335(24):17928. KillenJD,FortmannSP,DavisL,etal.Nicotinepatchandselfhelpvideoforcigarettesmokingcessation.JConsultClin Psychol1997;65:66372. KillenJD,FortmannSP,MurphyJrGM,etal.ExtendedtreatmentwithbupropionSRforcigarettesmokingcessation.J ConsultClinPsychol2006;74:28694. KillenJD,FortmannSP,NewmanB,etal.Evaluationofatreatmentapproachcombiningnicotinegumwithselfguided behavioraltreatmentsforsmokingrelapseprevention.JConsultClinPsychol1990;58:8592. KillenJD,FortmannSP,SchatzbergAF,etal.Nicotinepatchandparoxetineforsmokingcessation.JConsultClinPsychol 2000;68:8839. KornitzerM,BoutsenM,DramaixM,etal.Combineduseofnicotinepatchandguminsmokingcessation:aplacebo controlledclinicaltrial.PrevMed1995;24:417. LeischowSJ,NilssonF,FranzonM,etal.Efficacyofthenicotineinhalerasanadjuncttosmokingcessation.AmJHealth Behav1996;20(5):36471. LewisSF,PiaseckiTM,FioreMC,etal.Transdermalnicotinereplacementforhospitalizedpatients:arandomizedclinical trial.PrevMed1998;27:296303. MylesPS,LeslieK,AnglissM,etal.Effectivenessofbupropionasanaidtostoppingsmokingbeforeelectivesurgery:a randomisedcontrolledtrial.Anaesthesia2004;59:10538. Niaura R, Spring B, Borrelli B, et al. Multicenter trial of fluoxetine as an adjunct to behavioral smoking cessation treatment.JConsultClinPsychol2002;70(4):88796. Nides M, Oncken C, Gonzales D, et al. Smoking cessation with varenicline, a selective alpha4beta2 nicotinic receptor partialagonist:resultsfroma7week,randomized,placeboandbupropioncontrolledtrialwith1yearfollowup.Arch InternMed2006;166(15):15618. OnckenC,GonzalesD,NidesM,etal.Efficacyandsafetyofthenovelselectivenicotinicacetylcholinereceptorpartial agonist,varenicline,forsmokingcessation.ArchInternMed2006;166(15):15717. PerngRP,HsiehWC,ChenYM,etal.Randomized,doubleblind,placebocontrolledstudyoftransdermalnicotinepatch forsmokingcessation.JFormosMedAssoc1998;97:54751. ProchazkaAV, KickS, SteinbrunnC,etal.Arandomizedtrialofnortriptylinecombined withtransdermalnicotinefor smokingcessation.ArchInternMed2004;164:222933. Puska P, Korhonen HJ, Vartiainen E, et al. Combined use of nicotine patch and gum compared with gum alone in smokingcessationaclinicaltrialinNorthKarelia.TobControl1995;4:2315. RichmondRL,KehoeL,deAlmeidaNetoAC.Effectivenessofa24hourtransdermalnicotinepatchinconjunctionwitha cognitivebehaviouralprogramme:oneyearoutcome.Addiction1997;92:2731. Sachs DP, Sawe U, Leischow SJ. Effectiveness of a 16hour transdermal nicotine patch in a medical practice setting, withoutintensivegroupcounseling.ArchInternMed1993;153(16):188190. *Schneider NG, Jarvik ME, Forsythe AB, et al. Nicotine gum in smoking cessation: a placebocontrolled, doubleblind trial.AddictBehav1983;8:25361. SchneiderNG,OlmsteadR,ModyFV,etal.Efficacyofanicotinenasalsprayinsmokingcessation:aplacebocontrolled, doubleblindtrial.Addiction1995;90:167182. SchneiderNG,OlmsteadR,NilssonF,etal.Efficacyofanicotineinhalerinsmokingcessation:adoubleblind,placebo controlledtrial.Addiction1996;91:1293306. Simon JA, Duncan C, Carmody TP, et al. Bupropion for smoking cessation: a randomized trial. Arch Intern Med 2004;164:1797803. *Sonderskov J, Olsen J, Sabroe S, et al. Nicotine patches in smoking cessation: a randomized trial among overthe countercustomersinDenmark.AmJEpidemiol1997;145:30918. Stapleton JA, Russell MA, Feyerabend C, et al. Dose effects and predictors of outcome in a randomized trial of transdermalnicotinepatchesingeneralpractice.Addiction1995;90:3142. SutherlandG,StapletonJA,RussellMA,etal.Randomisedcontrolledtrialofnasalnicotinesprayinsmokingcessation. Lancet1992;340:3249. SwansonNA,BurroughsCC,LongMA,etal.ControlledtrialforsmokingcessationinaNavyshipboardpopulationusing nicotinepatch,sustainedreleasebupropion,orboth.MilMed2003;168:8304. Tashkin D, Kanner R, Bailey W, et al. Smoking cessation in patients with chronic obstructive pulmonary disease: a doubleblind,placebocontrolled,randomisedtrial.Lancet2001;357(9268):15715.


Tonnesen P, Mikkelsen KL. Smoking cessation with four nicotine replacement regimes in a lung clinic. Eur Respir J 2000;16:71722. Tonnesen P, Norregaard J, Mikkelsen K, et al. A doubleblind trial of a nicotine inhaler for smoking cessation. JAMA 1993;269:126871. TonnesenP,NorregaardJ,SimonsenK,etal.Adoubleblindtrialofa16hourtransdermalnicotinepatchinsmoking cessation.NEnglJMed1991;325:3115. TonnesenP,PaolettiP,GustavssonG,etal.Higherdosagenicotinepatchesincreaseoneyearsmokingcessationrates: resultsfromtheEuropeanCEASEtrial.EurRespirJ1999;13(2):23846. TonnesenP,TonstadS,HjalmarsonA,etal.Amulticentre,randomized,doubleblind,placebocontrolled,1yearstudy ofbupropionSRforsmokingcessation.JInternMed2003;254:18492. Tonstad S, Farsang C, Klaene G, et al. Bupropion SR for smoking cessation in smokers with cardiovascular disease: a multicentre,randomisedstudy.EurHeartJ2003;24(10):94655. Transdermal Nicotine Study Group. Transdermal nicotine for smoking cessation. Sixmonth results from two multicentercontrolledclinicaltrials.JAMA1991;266:31338. Wagena EJ, Knipschild PG, Huibers MJ, et al. Efficacy of bupropion and nortriptyline for smoking cessation among peopleatriskfororwithchronicobstructivepulmonarydisease.ArchInternMed2005;165:22869. WestmanEC,LevinED,RoseJE.Thenicotinepatchinsmokingcessation.Arandomizedtrialwithtelephonecounseling. ArchInternMed1993;153:191723. Wong GY, Wolter TD, Croghan GA, et al. A randomized trial of naltrexone for smoking cessation. Addiction 1999;94:122737. ZellwegerJP,BoelcskeiPL,CarrozziL,etal.BupropionSRvsplaceboforsmokingcessationinhealthcareprofessionals. AmJHealthBehav2005;29:2409.

HJAubin,ABobak,JRBritton,COncken,CBBillingJr,JGong,KEWilliams,KRReeves.Varenicline versustransdermalnicotinepatchforsmokingcessation:resultsfromarandomisedopenlabeltrial ThoraxOnlineFirst,publishedonFebruary8,2008as10.1136/thx.2007.090647

10NancyA.Rigotti,MD;AndrewL.Pipe,CM,MD;NealL.Benowitz,MD;CarmenArteaga,PhD;Dahlia Garza,MD;SerenaTonstad,MD,PhD,MPHEfficacyandSafetyofVareniclineforSmokingCessationin PatientsWithCardiovascularDisease.ARandomizedTrial.Circulation.2010;121:221229

U.S.DepartmentofHealthandHumanServices.Thehealthconsequencesofsmoking:areportofthe Surgeon General. Atlanta, GA, U.S. Department of Health and Human Services, Centers for Disease ControlandPrevention,NationalCenterforChronicDiseasePreventionandHealthPromotion,Officeon SmokingandHealth,2004.
11

Você também pode gostar