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Alireza Mehdizadeh, Afsoon Fazelzadeh, Heshmatollah Salahi, Jamshid Rouzbeh, Seyed Ali Malek-
Hosseini. Southern Iran Transplant Center, Nemazee Hopspital, Shiraz, Fars, Iran.


Renal transplantation is now considered the best therapeutic option for chronic renal failure. It was carried
out for the first time ever in Iran in 1963, in Southern city of Shiraz, Nemazee Hospital. The process
accelerated after establishment of Shiraz (Southern Iran) Organ Transplant Center in 1988; as a leading
center for organ transplantation and as the only center for liver transplantation in Iran. The present study is
a report of long-term results of the first 1200 operations performed in this center.
This retrospective study included all kidney transplanted patients who were operated in Shiraz Organ
Transplant Center since Dec. 1988 till Dec. 2003. Patients files in addition to Persian Network for Organ
Transplant (PNOT) were used as sources of data. The immunosuppressive protocol and general
procedures used in our transplant unit are nearly the same for all patients and have been described
previously. [1] Regular indefinite follow-up was considered uniformly for all patients.
Graft loss was defined as nephrectomy, return to dialysis, or death with a functioning graft. The diagnosis of
acute rejection was made by clinical rising of serum BUN and creatinine and also confirmed by biopsy.
Graft and patient survival rates in eligible cases were computed with the Kaplan-Meier analysis.
Recipients were 808 males, 392 females; mean age was 33.6 12.5 years. 86% of cases used organs from
living donors (40% related, 41% unrelated, and 5% spouses) and 14% from cadaveric source. Most
Common causes of end-stage renal disease were chronic glomerulonephritis (18.2%), reflux nephropathy
(13.4%), and diabetic nephropathy (10.1%). In 215 (17.9%) patients; 156 patients (13%) died in the post-
transplant period. Most common causes of death were cardiovascular (28.3%), graft loss (20.7%) and
infections (19.6%). The 1 and 3 year patient survival rates were 94% and 91.5%; and graft survival rates
were 88% and 84%.
Although the success rate of operations has not been so satisfactory at the beginning, the current data
reflecting a survival rate of >90% is comparable to major centers throughout the world.

Sunday, July 16, 2006

Poster: Transplantation - Experimental

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