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•Pretreatment
Mixture of class 1 and class 2 solvents with n-paraffin
mixed in for retention index calculation was injected as
sample. References
See Shimadzu GC Datasheet No. 24 for details
concerning separation results for each type of column for
the 85 organic solvent elements including target elements
for working environment measurement.
•Summary of Guideline
(1)Residue solvent should be reduced to a level appropriate to product standard, GLP or other quality criteria or less.
(2)Class 1 solvents that are known to cause non-permissible toxicity are not to be used without appropriate reasons.
(3)The residue of class 2 solvents that show toxicity of a specified level or above, although not to the extent of class 1, should be controlled.
(4)Ideally, class 3 solvents with minimal toxicity should be used.
(5)In the case of class 1 and class 2 solvents, tests should be performed using the gas chromatography method, etc., that
can individually detect solvents.
(6)Only in the case of class 3 solvents, loss on drying method, which does not specify the type of solvent, can be used.