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Contents
The Only Way to Reverse Alzheimers .................... 1 Chapter 1: Niacinamide Reverses Memory Loss .... 2
Benefit From Taking It Now ................................. 2 The Best $30 Youll Ever Spend ........................... 2 Other Benefits of Niacinamide ............................. 3 Additional Therapeutic Uses ....................... 5 Getting the Most for Your Money ......................... 6
lzheimers is a scary disease. It seems to come without warning, and, worst of all, until now theres been no cure. Currently the best one can hope for is to slow its progression with various medications, supplements, and changes in diet and lifestyle. Named after the German psychiatrist who discovered it, Alzheimers is a progressive, degenerative disorder that attacks nerve cells in the brain and leads to a disruption of memory, thinking, and normal behavior. In Alzheimers, waxy clumps of protein fragments called beta-amyloid plaques form around and inside nerve cellsbreaking vital connections and leading to nerve destruction. Although some individuals live with the disease for 20 years or more, the average person with Alzheimers lives only eight years following diagnosis.
Being impaired from Alzheimers can be an individuals worst nightmarenot to mention that of the persons family. With Alzheimers, the patients mind seems to have completely vanished from an otherwise healthy body. The individual becomes the total responsibility of family members or other caregivers. Its a situation we would all like to avoid. Sadly, there seems to be little coordinated effort to organize a program to actually prevent Alzheimers and other brain diseases, even though research indicates these problems are preventable for the most part. Contrary to popular belief, brain disease and degeneration are not inevitable consequences of aging. In fact, theres really no such thing as senile dementia. Research has shown that, just as with every other disease or malfunction in the body, there are specific reasons for senility and other failings of the brain. Also, as with other diseases, research has shown that there are natural ways to prevent and treat Alzheimers and other brain impairments. In this report, youll learn that there are several steps you can take to protect yourself from Alzheimers and memory loss. The first chapter covers what I consider to be the most exciting breakthrough in the treatment and potential cure of Alzheimersa form of vitamin B3 called niacinamide. Next, Ill cover some other nutritional therapies for preventing and treating Alzheimers. Ill also tell you about the tests for diagnosing Alzheimers and some Alzheimers imposters that could be causing memory loss. In addition, Ill explain the diabetesAlzheimers connection and the role of environmental toxins and drugs in causing Alzheimers and other brain diseases. The last two chapters of this report describe ways to strengthen your brain and improve your memory.
Over 5 million Americans now have Alzheimers, and that number is expected to grow to over 14 million by 2050. Currently, 10 percent of Americans over age 65 and nearly half of those 85 or older have the disease. In addition, the number of Alzheimers cases worldwide is expected to quadruple by 2050, from the current 26.6 million to over 100 million. If the current trend continues, one out of every eight baby boomers in this country will develop Alzheimers. Being a baby boomer myself, those odds are pretty frightening. Why is the number of Alzheimers cases increasing at such a dramatic rate? Alzheimers appears to be one of the diseases linked to our civilized lifestyle. In less-developed areas of the world, like Africa, the disease is practically nonexistent, which leads one to suspect that exposure to environmental pollutants and the unnatural food products so prevalent in our diets today play a critical role in this and other modern diseases.
ver the years, Ive uncovered a considerable amount of research on natural solutions for preventing or slowing the progression of the disease, but only recently has there been research finding that the memory loss of Alzheimers can actually be restored. Specifically, its been discovered that nicotinamide (another term for niacinamide, an alkaline form of niacin or vitamin B3) can restore the memory loss caused by this dreadful disease. Researchers at the University of California at Irvine gave the human dose equivalent of 2,000 to 3,000 mg of niacinamide to mice with Alzheimers disease. After treating the mice for only four months, they discovered what should have been front-page news in every city in the world. Cognitively, they were cured, said Dr. Kim Green, one of the researchers. They performed as if theyd never developed the disease. (J Neurosci 08;28:1150011510) The researchers were obviously both surprised and excited about what they discovered. Rarely do you hear researchers using the word cured, but thats exactly what happened. At the end of the study, the diseased mice that were treated with niacinamide performed just as well in memory tests as healthy mice. The niacinamide not only protected their brains from further memory loss, it also restored lost memory function. Dr. Green said, The vitamin completely prevented cognitive decline associated with the disease, bringing them back to the level theyd be at if they didnt have the pathology. If this wasnt exciting enough, niacinamide also improved memory and behavior in the mice without Alzheimers. I probably shouldnt have been that surprised, but the reaction from the medical community and mainstream press actually shocked me. The Alzheimers organizations have practically ignored this study and continue to follow the party line that high doses of vitamins can be toxic and shouldnt be taken except under the supervision of a doctor. And practically every article I saw reporting on the research offers the same warning. This is total bull.
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of problems associated with deficiencies of niacinamide. He discovered that many of the physical and mental problems associated with normal aging are actually the result of inadequate amounts of niacinamide in the diet. With the help of his wife, Dr. Kaufman was meticulous at documenting the results he obtained using niacinamide, particularly in the areas of fatigue; muscle strength and working capacity; loss of balance; depression; and joint mobility and osteoarthritis. (See Other Benefits of Niacinamide below.) If he were still with us, Dr. Kaufman would surely be pleased to learn that his program could also be effective in the treatment of Alzheimers. While the above clinical trials plan on utilizing 1,500 mg of niacinamide twice daily, I wish the researchers would study Dr. Kaufmans work and his findings on dosing amounts. Dr. Kaufman had experience with over a thousand patient-years of niacinamide use and was well-versed in how to obtain its greatest benefits. In my conversations with Dr. Kaufman, he said that niacinamide, being a water-soluble vitamin, was absorbed quickly into the bloodstream and central nervous system. Body levels began to rise within 15 minutes of ingestion, and peaked after about 90 minutes; after three hours most of the vitamin had cleared the body. This is why he felt that for maximum effectiveness it was crucial to give numerous doses through the day (and the night for extremely severe arthritic conditions). He also determined that 250 mg was about the most the body could absorb at one time. Taking multiple doses of 250 mg is the best way to maintain effective levels. He adjusted the daily dosage to the severity of the condition being treated, generally from 1,500 to 4,000 mg a day. (When I spoke with Dr. Kaufman and his wife they had both been taking 250 mg every three waking hours [six doses] for a total of 1,500 mg a day for over 55 years. He felt this is the ideal maintenance dosage, which needs to be taken for life. Considering the ever-increasing rate of Alzheimers, arthritis, and various neurological diseases, I believe he was right.) Based on his observations and studies, it would appear that Alzheimers patients would achieve the best results if they took 250 mg every 1 hours (a total of 12 doses). I
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highly recommend this niacinamide protocol for either preventing or treating Alzheimers.
30 minutes. Muscle strength also improved after 30 minutes in about 30% of the patients. Keep in mind that Dr. Kaufman made these initial findings by monitoring each patient in his office for an hour or longer after they took their very first dose of niacinamide. More pronounced improvement was observed as the patients continued on the therapy over a period of several months.
Depression
Dr. Kaufman noticed that states of depression related to niacinamide deficiencies are most commonly found in people over the age of 55. Granted, supplementing with niacinamide isnt a cure-all for depression or any other ailment, but in many cases it can lead to significant improvements. Niacinamide is somewhat unusual when compared to most other vitamins because it easily and quickly enters the central nervous system. It also has an affinity for the same neurological receptor sites that the benzodiazepine class of drugs is designed to affect. (Benzodiazepines are tranquilizing drugs, such as Xanax and Valium.) In effect, niacinamide acts as a mild natural tranquilizer, but is entirely safe and non-addictive. It is not at all uncommon to begin to experience relaxation and increased energy within five to 10 minutes of taking just 100 mg of niacinamide. As soon as blood levels of niacinamide begin to rise, the vitamins calming effect on the central nervous system becomes evident. Patients who suffer from long-term, deeper depression will generally respond within the first two weeks if niacinamide therapy is going to be of benefit.
Loss of Balance
There are three methods Dr. Kaufman used to check for a loss of balance. (If you intend to test yourself using any one of these methods, have someone standing nearby that can keep you from falling.) In general, the more tests you can pass, the greater your sense of balance. 1. Start by standing on one foot for a minimum of 15 seconds. 2. Next, stand on the same foot with your eyes closed for a minimum of 15 seconds. 3. Finally, while standing on the right foot, raise your left foot up and place your left heel one inch in front of the right knee cap. Keep your hands at your sides the entire time. If you can stand in that position with your eyes open for at least 15 seconds, then repeat the test with your eyes closed. Each of these tests should be done twice, once balancing on the right foot and once on the left. Being able to balance yourself properly depends on several things. One of these involves certain nerve fibers running up and down the spinal column that tell the brain the location and angle of each joint in your body. A deficiency of niacinamide has been shown to interfere with these pathways and affect your ability to stay balanced. Taking niacinamide can have a very positive effect on balance, and most people see gradual improvements over a period of several months. If you want to see if theres any immediate improvement, simply repeat Dr. Kaufmans balance tests 30 minutes after taking a dose of niacinamide. Even if you dont see a difference right away, stick with it as it may take up to three months of constant therapy to achieve noticeable progress.
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compound or analgesic. Apparently, it is niacinamides ability to trigger actual repair of the joint surfaces that leads to the dramatic reduction in pain and inflammation. I want to mention, though, that niacinamide is not something that will work in every single case. Obviously, some joints have been damaged so severely that nothing will help. There are a few other circumstances I can think of that can interfere with niacinamides effectiveness in treating arthritis and other conditions.
works out to 1,500 mg, but the effects will not be nearly as effective as taking 250 mg every three hours. Dr. Kaufmans protocols are designed to keep blood levels consistent throughout the day.
800-824-4491) and Jarrow Formulas (www.jarrow.com or 310-204-6936). Another point Id like to make about niacinamide products concerns the time-released niacinamide supplements that a few companies have come out with to make it easier to take high doses of niacinamide. The problem with these time-released products is that they can possibly cause liver problems, so you would need to get periodic tests to monitor liver function. I dont recommend taking these products. (Taking straight niacinamide using Dr. Kaufmans protocol outlined above has never caused any liver problems or other side effects. Apparently, the carefully balanced blood levels make it easy for both the liver and the kidneys to deal with the higher levels of niacinamide.) At this point I cant say for certain that niacinamide in high doses will completely reverse memory loss in humans the way it did in mice. But considering its safety, availability, and cost, niacinamide is certainly worth a tryparticularly since no other viable options are currently available. In the above study with mice, it didnt just improve the problem, it proved to be a cure. (See for yourself whether niacinamide improves your memory by taking the self-test on page 37 both before and a few weeks after you start taking the supplements.) The worst-case scenario would be that someone wastes $20 or $30 while improving their sense of balance, any existing arthritis, mobility problems, fatigue, and muscle weakness and lowering their risk of cancer. Wouldnt it be nice if all failed treatment programs had such side effects.
lthough niacinamide appears to be the only nutrient that can actually reverse the memory loss caused by Alzheimers, there are several nutrients that have been found helpful in preventing the disease or slowing its progression. This chapter covers these nutrients. Eating foods that contain these nutrients and taking a few nutritional supplements may seem like too simple a solution for a disease that baffles even the most learned medical experts. But as our foods become more processed and adulterated, I believe a return to simple,
whole, natural foods and nutritional supplements is the key to protecting you from Alzheimers.
blueberries can prevent age-related memory problems. (Nutr Neurosci 04;7(2):7583) In another study, researchers with the Department of Agriculture at Tufts University tested the effects of blueberry supplementation on older animals. Their results were so impressive they included the following statement in the summary of their research report: Our data indicate for the first time that it may be possible to overcome genetic predisposition to Alzheimers disease through diet. Im astounded that something this important wasnt reported by the mainstream media. This one simple suggestion may have the power to save thousands of individuals and their families the intense suffering and sadness caused by this horrible disease. (Nutr Neurosci 03;6(3):153162) One recent discovery is that blueberries contain a compound called pterostilbene. As more people learn of this discovery, I suspect youll begin to read more about the amazing properties of pterostilbene in the next few years. Many of its effects are similar to those caused by the compound resveratrol, which is found in red wine. Like resveratrol, pterostilbene has strong antioxidant capabilities, is a potent cancer-preventive agent, and helps protect the heart and cardiovascular system. But pterostilbene also has a unique capability not associated with resveratrol. Pterostilbene appears to be a very potent agent against diabetes. It may be possible that other types of berries contain pterostilbene, but so far blueberries seem to be the primary source. Pterostilbene is also found in darker grapes, but not in red wine as it doesnt seem to survive the winemaking process. Theres a product in Ayurvedic medicine called Drakshasava that has been prescribed as a heart tonic for hundreds of years. Its not that well known in this country and difficult to find. French researchers analyzed the product a few years ago, and found it contained both resveratrol and pterostilbene, which we now know inhibit platelet aggregation and increase the good HDL form of cholesterol. The fact that ancient healers were able to determine the benefits of such products never ceases to amaze me. (J Ethnopharmacol 99;68(1-3):7176) I cant stress highly enough the importance of adding blueberries to your diet, and when fresh berries arent available, you can use concentrated berry powder. In fact, Ive found a blueberry powder called Nutri-Fruit that concentrates an amazing amount of pterostilbene into a teaspoon.
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I sprinkle the powder on yogurt, on fruit salad, and in teas. I also love to eat a spoonful directly out of the container. (It may make my tongue and mouth look like a kid whos just finished a Popsicle, but it tastes great and sure freshens my breath.) You can order Nutri-Fruit Blueberry by calling 866-3437848 or at www.nutrifruit.com.
Curcumin/Turmeric
If youve ever eaten Indian food, youll never forget the color, smell, and taste of curry. This flavoring is actually a combination of spices, one of which is turmeric (Curcuma longa). The compound curcumin is responsible for the yellowish-orange color and distinctive smell of turmeric. Curcumin is more than just a simple pigment, however. It is a very potent medicinal remedy with a wide variety of uses. Turmeric is one of the primary spices of Indian culture the average daily adult intake in India is estimated at 400 mg. It has also been widely used in Ayurvedic medicine. In light of research finding that the curcumin in turmeric can lower risk of Alzheimers, it should come as no surprise that India has one of the lowest rates of Alzheimers in the world. (Only one percent of the elderly in India suffer from Alzheimers, compared to nearly half of those over age 85 in the US.) Studies have shown that when either turmeric or curcumin was added to the diets of animals bred to develop Alzheimers, the brain damage was significantly lessened. One theory is that Alzheimers is caused by inflammation in the brain. Some time ago, it was found that the regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) could also decrease the Alzheimers risk, but the long-term side effects, including gastrointestinal bleeding and liver and kidney damage, werent a good trade-off. Researchers at the University of California found that the amyloid plaques that develop in the brains of Alzheimers patients were reduced by over 40 percent in animals fed curcumin. Additionally, there was less inflammation and free-radical damage in the brain. (J Neurosci 01;21(21):83708377) More recently, researchers found that when mice susceptible to Alzheimers were fed curcumin at a dosage equivalent to that consumed daily by individuals in India (derived from turmeric in their curry), they had roughly half as many waxy brain plaques as the mice not fed curcumin. While the
protein fragments still form in the presence of curcumin, it appears that the spice component blocks them from combining into waxy clumps. (J Biol Chem 05;280(7):58925901)
Acetyl-L-Carnitine
Research suggests that the progression of Alzheimers disease can be slowed by increasing acetyl-L-carnitine in the diet. Researchers studied 130 Alzheimers patients from ten hospitals for one year. Sixty-three were given supplemental acetyl-L-carnitine, and 67 were given a placebo. Both groups worsened, but those in the treated group had a slower rate of deterioration. Those on acetyl-L-carnitine had better logical intelligence, verbal critical abilities, long-term verbal memory, and selective attention; and no significant side effects were observed. (Neurology 91;41(11):17261732) This study suggests that Alzheimers patients dont produce adequate amounts of acetyl-L-carnitine. Acetyl-L-carnitine is available in supplement form. I recommend starting with 500 mg per day, working up to 2,000 mg per day. You can find acetyl-L-carnitine supplements in health food stores or order them from Jo Mar Laboratories (800-538-4545 or www.jomarlabs.com). There are also natural ways to help your body produce acetyl-L-carnitine. The process of creating acetyl-L-carnitine begins with the transformation of the amino acid lysine by the liver. To create and use this compound, your body needs a healthy liver, sufficient lysine, and adequate amounts of certain nutrients.
A Healthy Liver
The liver is your largest internal organ, and it performs some of the most complex chemical tasks. One of its primary roles is to detoxify the pesticides, pollutants, alcohol, and medications that produce a constant stream of harmful byproducts. If liver function is normal, acetyl-L-carnitine levels can be increased by eating lysine-rich foods: cottage cheese, dark-meat chicken (the leg contains five times more than the breast), fish, peanuts, pumpkin and squash seeds, lima beans, chickpeas, lentils, soybeans, and instant skim milk. You can also take L-lysine supplements. Recommended dosages are 5001,000 mg daily, taken before meals. You can find L-lysine in health food stores or order it from Jo Mar Laboratories (800-538-4545 or www. jomarlabs.com).
An Unhealthy Liver
When the liver is not healthy, it starts to degenerate and disrupt many vital functions, including the conversion of lysine. Fortunately, a natural extract from the seeds of the milk thistle plant has been shown to trigger the regeneration of liver cells. (Wien Klin Wochenschr 80;92(19):678683) (Arzneimittelforschung 73;23:161) A 70-percent extract of the herb Silybum marianum, known as silymarin, appears to be most effective. No toxicity problems and only minor temporary side effects (headaches or stomach upset during the first few days on the extract) have been reported. Improved liver function often occurs in as little as two weeks, and restoration of full enzyme activity may occur in the first 30 days. Recommended dosages range from 150 to 300 mg taken three times daily. Silymarin extract should be taken as long as positive results are experienced or as long as a doctor feels its necessary. Several companies market standardized silymarin extracts. Enzymatic Therapy Inc. makes an excellent product called Silybin Advanced. Its available in health food stores, or you can order it from Enzymatic Therapy at 800-783-2286 or www.enzymatictherapy.com.
their condition stabilized and they did not experience the additional loss of cognitive function that was expected. I dont know of any drug therapy that can totally halt the progressive loss of mental function in Alzheimers the way alpha lipoic acid did in this study. (Arch Gerontol Geriatr 01;32:275282) It has no side effects, and is widely available in health food stores or you can order it from the Vitamin Shoppe at 866-293-3367 or www.vitaminshoppe.com.
A more recent Swedish study revealed the connection between a genetic predisposition for developing Alzheimers and deficiencies in vitamin B12 and folic acid. The study found that in a group of 167 healthy older individuals (average age 83), 28 carried a gene mutation found to increase the risk of dementia, and 54 did not. Researchers were unable to determine the status of the other 85. Further examination revealed that previously undiagnosed deficiencies of vitamin B12 and folic acid had a far more detrimental effect in those with the genetic fault and significantly increased their risk of developing Alzheimers disease. (Neuropsychology 04;18(2):362370) Deficiencies in vitamin B12 and folic acid are not just a matter of your diet. More often than not, these deficiencies are caused by medication. Numerous medications deplete vitamin B12, folic acid, or both. Some of the more common culprits include anti-inflammatory drugs (NSAIDs), antidiabetic agents, anti-cholesterol medications, and diuretics. Based on the research, its obvious you should make sure youre getting enough vitamin B12 and folic acid. I recommend supplementing with at least 400 mcg of folic acid and 100 mcg of B12especially if youre on medication.
One study in Chicago selected 815 individuals without Alzheimers disease, monitored clinical changes, and assessed their dietary niacin intake. After an average of four years, 131 in this group developed Alzheimers disease. Adjusting for all the important risk factors for the disease, the study found that those with the lowest niacin intake (an average of 12.6 mg per day) were 80 percent more likely to be diagnosed with Alzheimers than those with the highest intake (22.4 mg per day). And even among those who didnt develop Alzheimers, the cognitive decline in those with the highest niacin intake was almost 44 percent of those with the lowest intake. (J Neurol Neurosurg Psychiatry 04;75:10931099) There is obviously a very strong connection between a lack of niacin and Alzheimers. It just so happens that niacin and the other B vitamins are found in whole grains, which have largely been replaced by refined grain products. Other food sources of niacin are liver, fish, peanuts, and some mushrooms, which are not generally favorite foods of the general public. My dad is sharp as a tack and in his 80s, and its probably no coincidence that he just happens to love peanuts. He keeps a huge jar by his favorite chair. I also recommend taking a niacin supplement. A good dose for prevention would be anywhere from 200 to 1,000 mg a day, taken in divided doses. In the beginning, youre likely to experience niacin flush symptomsa tingling, hot sensation with redness on the face, chest, and arms. While the flushing might be a little unnerving initially, it is temporary (10 to 20 minutes). It can be minimized by starting out with smaller doses and gradually increasing them and, as your body gets used to it, the flushing will generally subside altogether. And, if youre a little strange like me, you might actually learn to like it.
Niacin
Another B vitamin that plays an important role in preventing Alzheimers is niacin, a form of vitamin B3. In Chapter 1, I told you about niacinamide, the alkaline form of vitamin B3. Niacin differs from niacinamide in that niacin dilates blood vessels and causes a flushing sensation, whereas niacinamide does not have this flushing effect. A couple of years ago, a subscriber concerned about developing Alzheimers wrote to me asking if she should use nicotine patches to prevent the disease, in light of research indicating that cigarette smokers are 50 percent less likely to develop Alzheimers than nonsmokers. I told her I didnt think smoking or using nicotine patches was the answer when there was a much safer alternative. Niacin, which is also called nicotinic acid, is a close cousin of nicotine, which is contained in cigarettes. Both niacin and nicotine stimulate the production of the neurotransmitter acetylcholine, which is needed primarily to facilitate the transmission of nerve impulses. But rather than use nicotine to increase acetylcholine, you can use niacin.
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and failing mental capacity. Over the years, researchers at the Chinese Academy of Sciences in Shanghai have been working to isolate the active components in the tea. Huperzine A is a direct result of this work. Only very small tests have been performed on Huperzine A in this country; however, it has been tested on hundreds of patients in China. In one double-blind study of 103 Alzheimers patients who received either huperzine A or a placebo twice daily for 8 weeks, 60 percent of the treated patients showed improvements in memory and brain function compared to 36 percent of the placebo group. (Zhongguo Yao Li Xue Bao 95;16:391395) Although huperzine A doesnt cure the disease or stop the destruction of brain cells, it alleviates many of the symptoms associated with Alzheimers by balancing abnormal brain chemistry. Basically, huperzine A inhibits an enzyme that breaks down acetylcholine, a neurotransmitter essential to mental function. While no one knows the total side effects of huperzine A, we do know that club moss tea has been used safely for centuries. Club moss (Shen Jin Cao) is not very easy to locate unless you live near an area with a large Chinese population or influence. In case you cant find it locally, we have located an Internet supplier. However, this company will only sell to health professionals, pharmacies, or health food stores. If you want to obtain the herb please ask your doctor or local health food store to order it for you. For information, contact the Mayway Corporation (www.mayway.com or 800-262-9929). Huperzine A is more readily available from a number of Internet retailers. I recommend huperzine A from Smart Nutrition (www.smart-nutrition.net or 858-270-7907).
Resveratrol
Along with the supplements and dietary changes Ive recommended above, one of the best things you can do to protect against Alzheimers is start taking resveratrolan extract from grape skins and grape vines. Researchers have learned that resveratrol appears to be a powerful substance for both the prevention and treatment of the disease. As I explained earlier, in Alzheimers patients, amyloid peptides bind together into plaques that embed themselves between brain cells. The peptides and plaques are toxic and
compound within the brain. These compounds called proteasomes break up and remove the plaques. (The proteasomes are able to distinguish between proteins that should be present, such as neurotransmitters, and those that shouldnt.) Further research found that resveratrol delivers a second punch to the disease as well, by actually neutralizing the brain cellkilling effects of the plaques. (Brain Res Rev 06;52:316326) (J Biol Chem 05;280:3737737382) (J Neurochem 06;96:305313) (Br J Pharmacol 00:131:711720) While the researchers I spoke with were elated with their findings, in their published reports they cautioned that resveratrol needs to be researched far more extensively before it can be recommended for use with Alzheimers disease. However, I wouldnt hesitate to recommend using resveratrol in Alzheimers patients now. In fact, it could be
something that might very well benefit others with memory loss, dementia, and other brain-related problems. Resveratrol is found primarily in red wine (ironically, grape juice is not a good source). To get the amount of resveratrol shown to be effective, 25 mg daily, youd need to drink several glasses of red wine. A better solution may be to try a resveratrol supplement, such as Resvert from SupplementSpot.com (www.supplementspot.com or 866-285-1998) or Longevinex from Resveratrol Partners (www.longevinex.com or 866-405-4000). I take a form of resveratrol every day, and I highly recommend you do the same to protect yourself from Alzheimers. To borrow one of my dads phrases, its cheap insurance and thats becoming a very rare commodity these days.
Chapter 3: Is It Alzheimers?
lzheimers disease has gotten so much publicity over the years that everyone over 60 with a poor memory wonders if theyre developing the disease. While Alzheimers may be the most common cause of memory loss, its not the only cause. Unfortunately, Alzheimers is frequently misdiagnosed. One study found that over half of those diagnosed with Alzheimers had other conditions that caused their memory loss. In the study, of the 200 patients diagnosed with Alzheimers, only 85 actually had the disease. In-depth examinations revealed that 103 patients had conditions that were more easily treated. The list of underlying illnesses included severe depression, alcohol-induced dementia, vitamin B12 deficiency, hypothyroidism, kidney failure, high blood calcium levels, nerve or brain tumors, toxicity from medication, mineral imbalances, and stroke. Another shocking aspect of this study revealed that many of the so-called Alzheimers patients had seen as many as three different doctors, and all of the doctors had diagnosed Alzheimers. Many of the patients were already assigned to nursing homes. On the brighter side, after proper treatment, many of the patients were able to return to normal lives.
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There could be several reasons for the possible misdiagnosis of Alzheimers. One of them relates to expense and insurance coverage. In-hospital evaluations utilizing CAT scans and other expensive diagnostic tools were needed to help determine the correct underlying problems in this study. Another reason may be that doctors are caught up in the Alzheimers craze and dont spend the time and effort to search for other causes of the problem. Many of the illnesses I mentioned above have very distinct laboratory and/or clinical characteristics that distinguish them from Alzheimers. My purpose here is not to point the finger or blame anyone. Instead, you need to be aware of the strong possibility of being misdiagnosed for certain health problems. Many times a diagnosis is made by comparing your symptoms to those associated with a particular disease. But just because you start to have memory lapses or impairment of your sense of smell doesnt automatically mean you have Alzheimers. A closer look could reveal any number of problems as the cause of your impaired memory. Before we examine some other problems that may mimic Alzheimers, lets take a look at how Alzheimers is diagnosed.
does not definitively diagnose dementia, it does assess cognitive status. Nonstandard tests. There are also some nonstandard tests that are primarily used in investigational studies. These tests are either still in the experimental stages or too invasive or expensive to be used as part of a standard workup for Alzheimers. As I mentioned earlier, there is no biological marker for Alzheimers that has been identified that can replace a clinical exam, but research is ongoing to find a more definitive diagnostic test and a test for detecting Alzheimers before symptoms appear. Nonstandard, investigational tests include genetic tests, a high-resolution MRI, functional brain imaging with a PET scan, an EEG to measure brain wave activity, a cerebrospinal fluid test, and blood tests. One of these tests, the cerebrospinal fluid test, may be useful in the early detection of Alzheimers. In one clinical study, the test, which measures proteins in the spinal fluid, was found to be 87% accurate in predicting Alzheimers in patients with early cognitive impairment but before full dementia symptoms appeared. The study also found that the test was 95% accurate in ruling out Alzheimers in those tested.
Urinalysis Blood count for anemia, infection Serum electrolyte levels to investigate metabolic
disease
Serum chemistry panel, including liver function tests Thyroid panel Serum vitamin B12 levels Neurosyphilis serology Serum toxicology for drug use Screens for connective tissue disease HIV
Radiological tests to examine the brain are not considered part of a standard workup, but they are frequently ordered to help rule out conditions such as a brain tumor, tissue damage from stroke, and hydrocephalus. The most common brain imaging test used is an MRI (magnetic resonance imaging). An MRI can reveal brain tissue loss patterns characteristic of Alzheimers and can help rule out other forms of dementia. Research has found that an MRI can detect changes in the brain that predict the development of Alzheimers. Neuropsychological tests are used to evaluate a patients cognitive status as well as emotional, psychological, motor, and sensory functions. These tests must be performed for a clinical diagnosis of Alzheimers, and they are helpful for ruling out other forms of dementia. Neuropsychological tests are also used to document progression of Alzheimers. The most commonly used neuropsychological test is the Mini-Mental State Exam (MMSE). Although the MMSE
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Alzheimers Imposters
In addition to the conditions I listed at the beginning of this chapter, two conditions that are often misdiagnosed as dementia or Alzheimers are iodine deficiency and normal pressure hydrocephalus.
Iodine Deficiency
The World Health Organization (WHO) has reported that iodine deficiency is the worlds most prevalent cause of brain disease. According to the WHO, 13 percent of the worlds population, or 740 million people, have a deficiency and 30 percent of the remainder are at risk. Theyve found that iodine-deficient individuals forfeit 15 IQ points, and 50 million individuals now have iodine-deficient brain damage. The WHOs answer to the problem is making iodized salt a universally consumed product. It is the most cost-effective method to get more iodine in the diet and has helped reverse the problem in many parts of the world. Unfortunately, solving the iodine-deficiency problem in this country isnt
so easy. While most Americans have used iodized salt for decades, we have other factors that complicate matters. One of the primary causative factors of iodine deficiency and hypothyroidism that has been overlooked in this country is iodine blockers in our food, and chemicals like fluoride and chlorine. Certain foods are iodine blockers. When eaten in excess or at times when iodine levels are low, thyroid function will be impaired. These foods include: cabbage, turnips, kale, broccoli, rutabaga, mustard greens, cauliflower, Brussels sprouts, and peanuts. These really arent much of an issue, however, because cooking inactivates the problem compounds in these foods. The most serious food culprit is soybeans. We now have soy-based infant formulas, soy milk and cheese, processed soybeans in the form of textured vegetable protein, and soybean oil in margarines and salad dressings, all of which can interfere with iodines absorption and assimilation. Chlorine and fluoride are other serious iodine blockers. Most of the chlorine we encounter comes from treated municipal drinking water, which has always been a concern of mine. And while about 55 percent of those in the US now drink fluoridated water, dont assume its not a problem just because your own water supply isnt fluoridated. Fluoridated water is used in the production of dozens of foods and beverages. Since fluoride content is unregulated in bottled water, you may find it there. Fluoride can be found in drugs, vitamins, supplements, juices, soft drinks, toothpastes, dental treatments, wheat flour processed with fluoride, and the fluoridated water contained in processed foods. I dont have room to address all the horrendous problems documented to occur with fluoride consumption, but some are increased chromosome damage, increased cancer rates, side effects from interactions with prescription and over-the-counter medications, and neurological problems. Also, thousands of studies have demonstrated that the symptoms of fluoride poisoning are identical to that of thyroid dysfunction due to iodine deficiency. Fluoride molecules compete with the uptake of iodine and drastically slow the production of essential thyroid hormones, even at the very low concentration of 1 part per million, the dilution recommended for fluoridation in the water supply. Dont drink fluoridated water. In fact, unless you have your
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own private, tested, uncontaminated well or other water source, I highly recommend drinking distilled water. In addition to eliminating or significantly reducing iodine blockers, dealing with hypothyroidism also usually requires iodine supplementation. Theres a simple self-test to determine if youre iodine deficient (see box below for this test). If youre iodine deficient, the iodine supplement I recommend is a liquid iodine product called Iosol by TPCS. Iosol can often be found in larger health food stores or ordered from TPCS (800-838-8727 or www.tpcsdirect.com) or Sullivan Creek Distributing (www.sullivancreek.com or 888-406-4066). (Note: Never ingest antiseptic or topical iodine. Iosol is the only form of iodine I recommend for internal use.)
have the problem. It can go unreported or get misdiagnosed as either dementia or Alzheimers. NPH is a condition in which spinal fluid builds up in the brain and creates pressureresulting in neurological problems. The first symptoms generally associated with NPH are the feeling of ones feet being glued to the floor, resulting in a shuffle when walking; urinary incontinence; and mild memory loss. Unlike Alzheimers, severe memory loss and confusion appear later in NPH. And unlike Parkinsons, NPH normally isnt associated with tremors. Unfortunately, because of misdiagnosis it generally takes between 7 to 9 years before its discovered that an individual actually has NPH and not Alzheimers. However, it can be detected through the use of brain scans or through a spinal tap. In contrast to the challenge of treating Alzheimers,
NPH can be treated successfully by draining the extra fluid surrounding the brain. The Hydrocephalus Association feels that as many as 375,000 individuals diagnosed with Alzheimers may actually be suffering from treatable NPH. If you know of someone diagnosed with Alzheimers, make sure his or her doctor has ruled out NPH. Because of a misdiagnosis, some patients have suffered for as long as 20 years with the belief that they had Alzheimers disease. And during that period, they gradually begin to suffer from the same type of symptomssuch as losing their memory or their ability to walk or speak, and experiencing progressive dementia. Once the pressure on the brain is relieved, their whole symptom picture improves and they begin to recover. For more information on NPH, contact the Hydrocephalus Association at www.hydroassoc.org or call 888-598-3789.
s I mentioned at the beginning of this report, the number of individuals with Alzheimers has risen dramatically in the past few decades. So has the number of individuals with type 2 diabetes. This may be no mere coincidence when you consider that high blood sugar levels are thought to play a role in the development of Alzheimers.
protein shakes for some time now (about teaspoon or roughly 500 mg).
glycation (or the Maillard reaction). During the next five or 10 years, I suspect you will begin to see more emphasis being placed on the harmful health effects of glycation. But if youre concerned about preventing health problems such as Alzheimers, as well as heart and artery disease, cataract formation, vision loss, and aging in general, glycation is something that you should know about now, not 10 years from now. In simplest terms, glycation refers to the combination of a sugar and a protein molecule. Most everyone has seen the effects of glycation in the kitchen. During baking, sugar whether it be white table sugar (sucrose), fruit sugar (fructose), or milk sugar (lactose)combines with certain amino acids in the grain proteins of flour. The chemical reaction that takes place causes loaves of bread and pastries to turn
brown. The same reaction also occurs when meats are glazed and coffee is roasted. Glycation also occurs in the body when the sugar in your blood (glucose) combines with the amino acids tryptophan, lysine, and arginine. During this reactive process, certain byproducts are created and released within the body. The byproducts are known scientifically as advanced glycation endproducts. And in terms of what advanced glycation endproducts do inside the body, their acronym says it all: AGE.
smallest blood vessels are the hardest hit, such as those in the back of the eye, the kidney, and the brain. These areas require a constant supply of glucose to meet their high energy requirements. As a result, they have the highest degree of glycation of any tissue in the body. Animal studies have confirmed that damage occurs to areas like the eyes when diets high in sugar are consumed. In particular, we now know that the cloudiness that begins to develop in the lens of the eye (more commonly known as cataracts) is a result of glycation. The increasing incidence of cataracts in this country is no doubt linked to our ever-increasing sugar consumption. Researchers also now believe that glycation lies at the heart of the alteration of proteins in the brain that causes Alzheimers disease. (Metabolism 80;29:12471252) (J Nutr 98;128:14421449) What all this boils down to is that refined sugars speed up the aging process and accelerate the formation of what we commonly call age-related diseases. If you are diabetic, youre well aware of the importance of monitoring sugar intake. For those of you who are not diabetic, here are some steps you can take to help keep your own blood sugar levels in the healthy range.
Now Imagine the Same Hardening Process in Your Heart, Eyes, and Brain
Proteins similar to those in the egg are found throughout your body. Proteins, after all, are the bodys building blocks. They are used in the construction of enzymes, blood vessels, muscles, nerve fibers, organ tissue, and just about every other body part. When glycation occurs and AGEs form, these proteins are changed forever. Just like the changes to the egg, the process is irreversible. The long-term health consequences of this protein-altering process can be disastrous. For example, when proteins in blood vessels undergo glycation, you get stiffer, less flexible arteries, which lead to higher blood pressure, plaque formation, blood flow blockages, heart and artery disease, stroke, and heart attack. The
Also, if you do choose to buy processed foods, opt for those that have at least a few grams of fiber. This will help slow the release of sugar into the bloodstream. 2. Use stevia to sweeten beverages and baked goods. Ive written at length about this natural substance in Alternatives. Unlike sugar, stevia doesnt trigger glycation or spikes in blood sugar. In fact, its now used in South America to help stabilize blood sugar in diabetics. And unlike artificial sweeteners, stevia has no aftertaste, side effects, or connection to cancer. Stevia is readily available in many health food stores, although you likely wont find it alongside sugar or other sweeteners. The Food & Drug Administration has approved the importation and sale of stevia as a dietary supplement, but not as a sweetener. All this means is that youll need to look in the supplement aisle. You should find it in both powder and liquid extract forms. Most people find the liquid extract closer to sugar in taste and easier to use. (One in particular that Ive used is made by Body Ecology and four drops of the liquid equals one teaspoon of sugar.) If you have trouble finding stevia in your area, you can contact Body Ecology (www.bodyecologydiet.com or 800-511-2660).
3. I would also recommend that you eat more fresh fruits and vegetables. As I mentioned earlier, eating unprocessed fruits high in fructose doesnt appear to cause the problems associated with glycation and AGEs. As is usually the case in nature, fruits have built in co-factors such as fiber, antioxidants, and minerals that help prevent such problems. So go for the pineapple, not the pineapple upside-down cake. 4. You can slow the aging process and dramatically improve your health by maintaining high antioxidant levels. Eating more produce as I recommended above is an excellent start, and you should also use a high-quality daily supplement to ensure adequate and consistent levels of these nutrients. In a recent Johns Hopkins University study, out of 4,740 people over the age of 65, those who supplemented their diets with vitamins C and E had a 64% lower risk of developing Alzheimers. The recommended dosages, based on the study, are 5001,500 mg of vitamin C and 4001,000 IU of vitamin E. Vitamin B6 and alpha lipoic acid have also been shown to be particularly beneficial in combating the effects of glycation.
he more we learn about the brain, the more we understand just how closely its connected to our immediate environment, lifestyle, and health habits. As I said at the beginning of this report, one of the major factors contributing to the dramatic increase in Alzheimers and other brain diseases has been exposure to environmental toxins, particularly toxic metals such as aluminum and mercury. Another contributing factor that has been largely overlooked is the use of drugs. In this chapter, Ill explain what you can do to protect your brain from these chemicals and toxins.
and commercial chemicals to diseases of the brain, including Alzheimers. Organophosphate-containing pesticides, herbicides, solvents, and plasticizers destroy acetylcholine, which as I told you in Chapter 2 facilitates transmission of nerve impulses in the brain. If you want to see what a case of Alzheimers disease looks like in fast motion, watch a bug after spraying it with pesticide. These chemicals are nerve agents that irreversibly inactivate acetylcholinesterase, which is essential to the production of the acetylcholine. Pesticides and these other organophosphate-containing products kill by attacking the nervous system of insectsand of humans as well. Neurological assault from chemicals is a complex, ongoing process. Their effects can be cumulative and may take years to manifest in symptoms or full-blown disease.
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Minimizing Exposure
I cant overstress the importance of avoiding contact with, and inhalation of, pesticides, herbicides, and toxic chemicals. Studies continue to link these household, farm,
You can take several steps to help minimize your chemical exposure. (For specifics on minimizing your exposure to aluminum and mercury, see those sections below.) Grow your own garden, when possible, or eat organically grown foods and hormone-free meat products. Avoid using amalgam dental fillings. Drink clean, pure water. I continue to recommend distilled water for drinking. Besides air, water is the only thing you ingest every single day of your life. Even the smallest amounts of chemicals or toxic metals can pose problems after a lifetime of accumulation. Whenever possible, avoid and/or minimize the use of drugs and vaccinations. Practically all drugs influence brain chemistry either directly or indirectly by altering hormonal, mineral, or metabolic pathways elsewhere in the body. And drugs come with their own list of toxic side effects. Using drugs in combination and/or on a long-term basis can multiply their toxic effects, many of which you may not be aware of until the damage has been done. (For more on the impact of drugs on the brain, see page 25.)
The other primary organ for toxin elimination is the skin. The use of saunas, along with an inexpensive vitaminniacin (100 mg three times a day)is one of the best methods to increase the ability of your skin to eliminate toxins.
Chlorella is a single-celled plant. Its cell walls bind with toxins in the digestive tract and carry them out. Take 1520 grams a day (34 teaspoons) for chelation. You may want to start slowly and work up, because chlorella works on your digestion, too. Intravenous chelation treatment, although controversial, is an effective and safe method of removing many of these toxins. The fact that it isnt covered by insuranceor accepted by conventional medical practitionershas resulted in its limited use. Many doctors, then, have resorted to prescription oral chelators like DMSA, which is very effective at removing mercury deposits. (More natural chelators for removing mercury are discussed in detail below.) A flood of nonprescription oral chelators has recently hit the market, but research to promote their use is grossly lacking, in my opinion. However, there is one nonprescription chelation product that I feel has merit. It is a suppository called Detoxamin and is sold by World Health Products (877-656-4553 or www.detoxamin.com). They sell a box of 30 suppositories (which is supposed to be equal to 10 IV chelation treatments) for about $220 a box. A less drastic method of removing toxic metals safely from the body involves the process of using mineral antagonists. The various cells in your body are constantly being repaired and replaced. Out of necessity, your body uses what raw materials are available at the time to build these new cells and repair their internal workings. For example, cells in your arteries require zinc to help make them stronger yet remain flexible. However, if zinc is deficient in the diet, the toxic metal cadmium can be used instead, if its available. The chemical structures of zinc and cadmium are such that the substitute can be made and the body will continue to functionthough far less effectively. Heres a list of the known mineral antagonists: Mineral Calcium Zinc Sulfur/Molybdenum Selenium Toxic Metal Lead Cadmium Copper Mercury
By ensuring that you get a steady and constant supply of necessary minerals and nutrients, and by avoiding environmental exposure to toxic metals, your body can replace any toxic building blocks as it repairs and rebuilds.
same pathological changes in the brain tissue that are found in Alzheimers patients. (Brain Res 98;784:284298) Ive said it many, many times in the past. Besides the air you breathe, water is the only thing you put into your body every single day of your life. Even minute levels of contaminants in your drinking water can accumulate in your system over time and cause major problems. Aluminum, especially when there is fluoride in the water, tends to accumulate in the lungs, liver, thyroid, bones, and brain. As the number of cases of Alzheimers continues to grow, the connection between aluminum and the disease seems to strengthen. I cant help but think that contaminated drinking water will soon be acknowledged as one of the causative factors.
products. You can make your own baking powder by combining 2 cups each of arrowroot flour and cream of tartar with 1 cup of potassium bicarbonate from your local drugstore. After sifting it together, you should store it in a closed jar. 4. Avoid aluminum-containing antacids, diarrhea medicines, and douches. Antacids that contain aluminum hydroxide, such as Amphojel and Mylanta, could cause a buildup of aluminum. Although you may absorb only a fraction of the amount, two tablespoons of Amphojel contains 665 mg of aluminum. 5. Switch from spray deodorants to either roll-ons, sticks or alternatives you can find in health food stores. Youll avoid inhaling aluminum-containing fumes. (Many people have switched to the deodorant crystals, but chemical analysis has shown these also contain aluminum.) 6. Make sure youre getting enough calcium either in the diet or through supplementation. Calcium hampers aluminums absorption by the body. 7. Drink distilled water if possible. Aluminum sulfate is widely used in the process of purifying water in this country. When added to the water it works as a coagulant to attract suspended particles, which can later be filtered out. Unfortunately some of the dissolved aluminum will remain in the water. (Post filtration aluminum levels are rarely, if ever, checked since the Environmental Protection Agency doesnt have any enforceable standards on aluminum levels in drinking water.) Aluminum is naturally abundant in the soil. And I realize that it would be impossible to avoid it altogether. Even still, any steps you can take to minimize your ingestion of aluminum will only improve your chances of avoiding diseases like Alzheimers.
silicon to aluminum-laced water supplies, it prevented the aluminum from being absorbed. It also caused an increase in the excretion of aluminum in urine and lowered aluminum concentrations in the brain, liver, bone, spleen, and kidneys. (Alzheimer Dis Assoc Disord 98; 12(2):8387) (J Inorg Biochem 98;69(3):171176) (Lancet 93;342:211212) (Chem Toxic 93;31(9)679685) For more on how to increase your intake of silicon, see box below.
occurring substance on earth. (Plutonium is said to be the most toxic.) Mercury is recognized as one of the most hazardous substances in our food and water, and has been linked to everything from mental impairment in our children to heart disease in adults, and is a possible contributor to the growing epidemic of Alzheimers. (Neuroreport 01;12(4):733737) Mercury contamination isnt something new; its just the awareness of it that has resurfaced in light of recent legislation phasing out use of incandescent light bulbs in favor of compact fluorescent lights (CFLs). While CFLs are more energy efficient, the average fluorescent light contains about 20 mg of mercury. (Some of the newer CFLs contain only about 4 mg of mercury, an amount that would just cover the tip of a ball-point pen.) This may not sound like much mercury, but consider the fact that it takes only a single gram to contaminate a 2-acre pond of water. Currently, about
A good maintenance dosage is 25 mg per day. If your daily nutrient doesnt contain silicon, take a silicon supplement. Jarrow Formulas makes an excellent silicon supplement called BioSil. It is a stabilized form of orthosilicic acid, which quickly raises serum silicon levels. The recommended dosage is six drops a day (three drops in the morning and three in the evening). This acid form of silicon is easily assimilated, but it tastes pretty nasty. Most people put the drops in either fruit or vegetable juice. Jarrow Formulas can be found in many health food stores. For a list of online retailers or local stores that carry BioSil, contact Jarrow Formulas (800-726-0886 or www.jarrow.com). Silicea, a homeopathic cell salt that comes in tiny pill form and quickly melts in your mouth, is another way to replenish silicon. I would suggest taking six tablets, three times a day, for a total of 18 a day. You cant overdose on these cell salts, and they are very inexpensive. Standard Homeopathic markets them in bottles that contain 1,000 tablets for around $12. Look for them in health food stores or you can go online to the Vitamin Shoppe (866-293-3367 or www.vitaminshoppe.com).
800 million fluorescent lamps are being produced yearly to replace those that burn out. Thats enough mercury to contaminate nearly 20 million acres of water. To prevent this contamination, a few states (California, Wisconsin, Ohio, Minnesota, Illinois, Indiana, and Michigan) have passed laws making it illegal to throw fluorescent bulbs in the trash. There are also companies that specialize in recycling these bulbs, for a charge of anywhere from $2 to $4 per bulb (for information see www.lightbulbrecycling.com or call 303-952-1020). Through recycling, over 99 percent of the mercury can be reclaimed and kept out of the environment. Thats not the case, however, when a bulb gets broken. When a fluorescent bulb breaks in your home, enough mercury vapor is released that the place should be considered a hazardous waste site, to be decontaminated by experts. Obviously, that never happens. In fact, most people arent even aware that breathing the released vapors or coming into contact with the broken bulb are dangerous. The EPA is. Not only did the EPA provide a special exemption to even sell mercurycontaining fluorescent lamps to the public, they also have very specific guidelines for cleaning up a broken bulb. (See box on page 24.) All of the recycling efforts are highly commendable, but I still think were going to see a very significant increase in mercury pollution for several years to come. And along with that were going to see increases in childhood mental deficiencies and cases of Alzheimers and other unexplained neurological diseases. Dont get me wrongI think widespread use of fluorescent bulbs has a place in solving our energy and environmental concerns. However, I do have a problem with their potential for contamination. The public is being told that the bulbs are an integral part of reducing our energy consumption and a way to help prevent global warming, but theyre not being told about the dangers involved and how to deal with them. I worry this is going to be another situation where 10 or 15 years down the road someone finally realizes that tens of thousands of individuals have suffered or died needlessly from increased mercury exposure.
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fillings) or through our respiratory tract (vapor from pollution or a broken fluorescent bulb). With our food and water supplies so widely contaminated, it will be difficult to avoid mercury completely. This is where a diet high in sulfur-rich vegetables, fruits, and other foods can help. These foods can bind with the mercury while its still transiting the intestinal tract and carry it out of your body. Youll find a partial list of high-sulfur foods below. I think Ive discussed each of these at one time or another through the years. Unfortunately, they dont receive the attention or research they deserveand probably never will. Most have strong antioxidant capability and are rich in various bioflavonoids. We now know they also have the added benefit of being able to lock on to mercury and prevent its absorption into the body. Cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, kale, chard, and watercress Other vegetables: asparagus, avocado, parsley, red peppers, and tomatoes Nearly all grains, legumes, nuts, and seeds Root vegetables such as carrots, radishes, turnips, garlic, and onions (but not potatoes) Fruits: blueberries, cherries, and grapes Animal products: cheese, egg yolks, meat
Based on the widespread contamination levels were seeing today, I would highly recommend adding several of these items to your diet every day. It wasnt that long ago that I reported the discovery that cilantro was an effective chelator of mercury. If the research money were available, Im sure wed find other vegetables that could provide similar protection.
toxic release. The reabsorption of mercury can be further minimized or avoided through a higher intake of the sulfurrich foods mentioned above. These help chelate or lock onto the mercury in the intestinal tract and move it out of the system. In addition to the high-sulfur foods, other known intestinal chelators are the blue-green algae spirulina and chlorella, aloe gel, and various calcium bentonite clays. Ive seen a short mercury detox program using alpha lipoic acid work wonders for many people. The program consists of taking to mg of alpha lipoic acid per every pound of body weight, every 3 hours for 3 days and 2 nights. (The time can be stretched to every 4 hours during the night to avoid interrupting sleep as much and then returning to every 3 hours during daytime.) This would translate to 20 to 80 mg of alpha lipoic acid every 3 hours for a person who weighs 160 pounds. If one wants to repeat the program they can wait for 11 days following the initial 3 days and 2 nights before starting again. Everyone reacts differently, so dosages often have to be adjusted depending on how one feels. Its generally better to use the lower dosages to begin with and work with a doctor familiar with this program.
For example, detoxifying after the removal of dental amalgam fillings would require a far more involved program. And even the short detox programs I mention above are not recommended if you have dental amalgam fillings. You dont want to be mobilizing and pulling mercury out of your fillings. If you have serious mercury toxicity I would highly recommend working with your doctor or other specialist trained in that area.)
Gastrointestinal or stomach cramps, spasms (Hyospaz, hyoscyamine) Diarrhea (Lofene, Logen, Lomotil) Pain, inflammation (Codeine or any of the dozens of medications that contain codeine, OxyContin, Oxydose, Roxidocone) Anxiety disorders, panic attacks, seizures, muscle spasm (alprazolam, diazepam) Fluid retention, high blood pressure, heart failure (Lasix, Capoten) Allergies, allergic reactions, arthritis (prednisone, Sterapred) Motion sickness (Scopace) Parkinsons disease (Cogentin, Akineton, Norflex) If you take any form of medication its important to understand there are side effects. It may come as a shock to many people that many of the side effects may not be discovered for years, if not decades, after a drug has been given the blessing of the FDA. When it comes to side effects, the pharmaceutical companies and the FDA are hoping the public will forget that it was drug use that caused these problems in the first place. In that respect, I guess destroying peoples memory and cognitive function works to their advantage.
The manufacturers of statin drugs list over 130 possible side effects. Muscle pain, tenderness, and weakness are just a few of the primary ones. Although the manufacturers fail to acknowledge it, based on what Ive heard directly from many users and/or their written accounts, it certainly appears to me that these neuromuscular degeneration problems could be from the disruption of cholesterol production. Cholesterol is an insulator for nerve fibers, and its also a primary component in the structure of cell walls. When either the coating or the cell walls themselves begin to break down, disrupting transmission of impulses in the brain, you start to see distinct changes in an individuals ability to function. The symptoms are those associated with neurological disease or damage, so it shouldnt come as any surprise that among statin users were seeing more cases being diagnosed as mini strokes (TIAs), senility, chronic fatigue, depression and, in more progressed cases, ALS (amyotrophic lateral sclerosis or Lou Gehrigs disease). Studies have shown that statins increase the incidence of memory loss, inability to concentrate, impaired judgment, confusion, disorientation, irrational thinking, and other signs of dementia and senility. This alone should be enough to scare anyone away from taking statins. Based on the evidence now available, 100 percent of statin users can expect a decrease in cognitive function. (Am J Med 04;117:823829) If you know of someone who still takes statin drugs (which is now practically anyone who has been diagnosed with a cardiovascular or high cholesterol problem), please warn them of the associated problems. Any sign of unexplained muscle weakness, cramps, twitching, slurred speech, difficulty in walking or motor skills, nerve pain, depression, memory loss, et cetera, could be just the tip of the iceberg. There are individuals in wheelchairs being diagnosed with ALS who can now trace their problems back to statin drug use. Dont let it happen to you or to someone you love.
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ne of the first signs of getting older seems to be a failing memory. Although a certain degree of forgetfulness and memory difficulty is normal, several steps can be taken at any age to help protect and preserve your brain function. When you begin to understand the influences your lifestyle and health habits have on your brain and adjust those accordingly, youll see that the brain will react much like your heart and other organs in your body. In simpler terms, the tools and techniques are currently available to prevent brain disease. Some may seem obvious while others arent so well known. In this chapter, Ill focus on ways you can fortify and strengthen your brain.
When there is an assault to the brain, a cognitive reserve allows messages to be re-routed through alternative networks and pathways. In essence, the more neuronal networks you have, the more damage to the brain you can sustain without exhibiting the signs of mental decline. In speaking to the researchers who are studying cognitive reserve, two comments were made that stuck in my mind. First, based on his lifelong work, one researcher told me the bad news is that everyone will eventually get Alzheimers if they live long enough. Second, the good news was that everyone has the ability to increase their cognitive reserve, regardless of age, and it is the most powerful tool we have to prevent the progression of the disease.
L-tryptophan is one of the few natural products I know that will increase serotonin levels.
nerve impulses in the brain and nervous system, through the formation of neurotransmitters. Until the fall of 1989, L-tryptophan was considered to be one of the safest and most powerful natural medicines for treating a long list of psychiatric conditions. Then reports surfaced that some individuals taking L-tryptophan were developing a condition called eosinophilia-myalgia syndrome. The problem was traced to a batch of contaminated products produced by the Japanese manufacturer Showa Denko. The FDA didnt just remove the contaminated batches of the amino acid, however. They recalled all L-tryptophan sold for human consumption, destroyed it, and banned all future sales. In 1994, the FDA ban was lifted, but skittish manufacturers were slow to reintroduce L-tryptophan. It wasnt until 2001 that companies began carrying it once again, and now its readily available from quite a few sources. You can get L-tryptophan in your diet, but its hard to get the amounts your nervous system needs. Foods with higher L-tryptophan content include wheat germ, oat flakes, eggs, cottage cheese, avocados, pork, salted anchovies, Swiss and Parmesan cheeses, and almonds. Fortunately, you can buy pharmaceutical-grade L-tryptophan from the Vitamin Lady (800-213-4906 or www.vitaminlady.com). Suggested dosages for L-tryptophan vary. In adults, it takes at least 12 grams to change blood levels. Take B6 (50100 mg) and niacinamide (100200 mg) with L-tryptophan to enhance its effects.
Use It or Lose It
Youve undoubtedly heard the saying, Use it or lose it. Well, its particularly true when it comes to the brainwhich needs mental exercise to stay healthy. Of course, learning a new skill or language gives the brain a workout and greatly improves function. The same goes for writing, reading, teaching, and even working crossword puzzles. Additionally, reading on a wide variety of subjects activates the brain in ways that arent fully understood. One hundred to three hundred years ago, it was thought that reading compresses time by allowing readers to experience the feelings and actions that are presented in the writing. According to this view, avid readers experience far more than what they otherwise would in a lifetime. A more recent view is that, when we read, we each derive our own ideas about the meaning of what weve read based on the unique experiences and ideas that each of us has acquired during our lives. According to this view, the creative ideas produced by your brain as you read are a result of the differences between what you are reading in contrast to your personal experiences and ideas. I know this view can be technical (and gets even more so if you really study it), but basically its saying that its impossible to have ideas without languageand thats why reading is so important. If youre a newsletter subscriber, Im probably preaching to the choir about the importance of reading, but whats clear is that copious amounts of reading can and should be a key component in maintaining your mental well-being.
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This decline in brain size isnt inevitable. Evidence points to nutritional deficiencies and inactivity as the primary causes. Fortunately, it appears that it is possible to halt the process, and even to reverse any brain shrinkage that has occurred.
low levels of vitamin B12 were associated with advanced brain shrinkage. In the study, 107 adults without any cognitive impairment were followed for five years. Annually during that period, each subject had their blood tested to assess the level of B12, and received an MRI to measure any change in brain volume. Those in the lowest third of B12 level were six times as likely to have accelerated brain shrinkage as those in the highest third. (Neurology 08;71:826832) Beyond age 50 or so, individuals are less able to assimilate the vitamin B12 that they take in through their diets. This reduction is due primarily to the conditions necessary for good digestion of B12. The first condition is an adequate supply of hydrochloric acid. The second necessary condition is an adequate supply of a compound known as intrinsic factor, which is secreted by cells lining the stomach and transports B12 through the wall of the small intestine into the bloodstream. When a B12 deficiency advances far enough, it creates a condition known as pernicious anemia. Outright symptoms include fatigue, shortness of breath, and pins-and-needles sensations in the hands and feet. A deficiency in B12 is also known to cause dementia, and the neurological changes can appear long before other signs. While pernicious anemia occurs in only two to three percent of the population, the
incidence of B12 deficiency among older adults may be as high as 30 percent. (Arch Neurol 90;47:10081012) Correcting a deficiency in vitamin B12 is a straightforward matter. If youre having trouble making use of the B12 that you do get from your diet, then you need to find a way to bypass the digestive system and get the vitamin directly into your bloodstream. For years, I recommended getting monthly injections of B12 from a knowledgeable doctor. Using this method, the vitamin is able to pass directly from muscle tissue into the bloodstream. I still believe that this method is effective, but it does require an initial visit to the doctor then monthly visits thereafter. Another solution is sublingual B12. In this formulation, you just place the tablet directly under your tongue. As it dissolves, the B12 passes into the bloodstream through the mucous membranes of your gums. Sublingual vitamin B12 is available anywhere other vitamins are sold. Look for a product that provides 1,000 mcg daily. To sum up, engaging in aerobic activity, maintaining a healthy weight, and correcting a vitamin B12 deficiency can go a long way toward preserving your brain size and even reversing any brain shrinkage that has already occurred.
n addition to building up your brain, other ways you can protect yourself from memory loss and boost your memory include improving your circulation, increasing your intake of lecithin and butyrate, and supporting your adrenal glands.
In a Polish study at the Neurology Department of Regional Hospital in Zyrardow, Poland, 35 people with known cerebral atherosclerosis were treated with Padma. The individuals ranged in age from 33 to 72 years, and suffered from one or more of the problems mentioned above. Nine had evidence of blockage in the carotid artery that feeds the brain, and 14 had experienced one or more transient ischemic attacks (TIAs) or silent strokes in the last two years. They were all given Padma for a total of three months at a dosage of 6 tablets a day for the first six weeks, and thereafter 4 tablets a day. Practically all showed remarkable improvements. Twenty-five reported immediate improvement in memory and the alleviation of emotional instability. In five of the nine patients with suspected blockages of the carotid artery, associated symptoms regressed almost completely, and in two other patients symptoms were greatly improved. None of those with a history of TIAs experienced any more such incidents. When this study was presented at a symposium in Poland, one of the neurologists commented that he knew of no substance other than Padma that can make the cerebral circulation so elastic.
Padma Basic
Padma Inc. of Switzerland has been making the formula under the name Padma 28 for the last 30 years. It is called 28 because it was based on the 28th formula in an ancient textbook of Tibetan medicine. A few years ago, the product Padma Basic from Padma Inc. became available in the US. It is the same product, except for very small amounts of one ingredient, aconite, which Padma 28 contains. There have been some questions as to the safety of aconite, so it isnt allowed in the US product. Tests have shown that removing the aconite doesnt appreciably change the beneficial effects of the product. Padma Basic contains the following herbs: Allspice (Pimenta dioica) Bengal Quince (Aegle marmelos) Calendula (Calendula officinalis) Cardamom (Elettaria cardamomum) Clove (Syzygium aromaticum) Columbine (Aquilegia vulgaris)
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Costus (Saussurea lappa) English Plantain (Plantago spp.) Gingerlily (Hedychium spicatum) Golden cinquefoil (Potentilla aurea) Heartleaved Sida (Sida cordifolia) Iceland moss (Cetraria islandica) Knotgrass (Polygonum aviculare) Lettuce (Lactuca sativa) Licorice (Glycyrrhiza glabra) Margosa (Azadirachta indica) Red Sandalwood (Pterocarpus sandalinus) Tropical Almond (Terminalia chebula) Valerian (Valeriana officinalis) Natural Camphor Calcium Sulfate These herbs are sourced from around the world and rigorously tested throughout the production process to ensure product effectiveness. The herbs are tested for identity, purity, and potency by chemical fingerprinting using high-pressure liquid chromatography (HPLC), gas chromatography (GC), and thin layer chromatography (TLC). Test batches of each herb are also sampled by trained tasters to check for astringency. We recognize only four tastes: sweet, sour, salty, and bitter. In addition to our four, Tibetan medicine includes astringent and hot. Padma Basic is packaged to have a five-year shelf life and is free of pesticides and contaminants. Research has repeatedly shown that it has no side effects or interactions with other medications. (It is still recommended, however, that it be taken 30 minutes before meals, and that other medications be taken at another time.) Dosages vary depending on age and condition. For adults, 6 tablets a day (2 tablets taken three times a day before meals) are recommended during the treatment phase of a problem. Once the problem has been resolved over a matter of weeks or months, you can generally taper back to a maintenance dose of 1 or 2 tablets a day. You can visit a health care professional to get Padma Basic, or purchase it yourself from EcoNugenics at 800308-5518 or www.econugenics.com.
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problems. If youre taking ginkgo, or considering it, dont let this study change your mind. (JAMA 02;288:835840) Ginkgo capsules are readily available, and certainly worth a try in Alzheimers patients. Make sure whatever ginkgo you choose has been standardized to contain 24 percent of the flavonoid glycosides. A good daily dosage is 10 mg. Enzymatic Therapy has a standardized product, available at www.enzymatictherapy.com or by calling 800-783-2286.
Truthfully, the results have been somewhat mixed. If there was any improvement at all, it appeared to be in slowing the progression or onset of the diseases rather than in treating them. When it comes to improving memory lapses, however, it appears that regular use of lecithin can be beneficial. For example, when a group of older individuals took two tablespoons of lecithin daily for five weeks, they exhibited fewer memory lapses and improved memory skills. (Res Soc Work Pract 94;4:349358) In another study involving college students, high doses of lecithin (the equivalent of about 10 tablespoons daily) significantly improved short-term memory skills within 90 minutes of consumption. (Clin Neuropharm 93;16(6):540549) With the inability to patent lecithin, its widespread availability, and its low cost, theres really not much financial incentive for anyone to perform large, long-term studies. The big players (such as pharmaceutical companies and government-sponsored researchers) will probably never spend enough time or energy on lecithin to learn just how beneficial it can be.
Its important to keep in mind that the fat-like components in lecithin are much like vitamin E and other fat-soluble vitamins. In many instances, it can take months for the body to build up a reserve of these compounds and realize their full effects. In other words, if you want to experience the full benefits of lecithin, you will need to take it consistently on a full-time basis. Granules are available from health stores or online from Bronson Laboratories (www.bronsonvitamins.com or 800-235-3200). Lecithin can also be purchased in liquid or softgel form, but the granular form is more economical.
from dementia, and maybe even from Alzheimers and other degenerative problems.
I should tell you that Butyrex has a really offensive odor. The word butyrate is derived from the Greek word for butter. Butter contains about 2 percent to 3 percent butyrate, and when butter goes rancid butyrate is what gives it the foul smell. The same goes for rancid Parmesan cheese. While were speaking of unpleasantries, butyric acid also contributes to the distinctive smell associated with vomit. You can lessen the smell of Butyrex by keeping it stored in the freezer. Sulforaphane supplements generally come in the form of broccoli sprout powders. There are several on the market, available in practically any health food store. Jarrow makes an excellent product, and Id just recommend following the directions that come with each product since the potencies vary somewhat. Its a lot less expensive, though, to develop a taste for broccoli. Another method of increasing your levels of butyrate is by consuming gum arabic (also called gum acacia). This is the natural gum produced in the Middle East that you see commonly used as a stabilizer in ice cream, chewing gum, and gummy candies. One small study using seven patients showed that you can double butyrate levels in only 8 weeks with a dosage of 25 grams a day. (Kidney Int 06;69(2):257265) At the above dosage gum arabic wouldnt be that inexpensive, but significant increases in butyrate levels could be obtained over a longer period of time using a dose of 510 grams of the powder per day. In bulk, it sells for less than $10 a pound (454 grams). I get mine from a company called Liberty Natural Products at www.libertynatural.com or 800-289-8427.
Its well known that as we get older our adrenal glands generally release less epinephrine and we begin to experience memory shortfalls. Dr. Gold has shown, in both animals and humans, that these age-related memory problems are often corrected or greatly improved with the administration of epinephrine. When older animals were given the epinephrine their adrenals were no longer producing, their memory was restored to the same level as that associated with young animals. After the positive results obtained in animals, Dr. Gold began to work with a group of patients suffering from either Alzheimers or memory problems brought on by brain damage. However, rather than use epinephrine (which would increase blood glucose levels) he simply had the patients drink a glass of lemonade, containing either 25 grams of glucose or a placebo (saccharin), immediately prior to a learning experience. He found that the glucose definitely enhanced the patients memories of the experience, and the benefits were long-lasting. When tested after ingesting glucose, the Alzheimers patients had actually doubled their memory scores. Some very important information can be learned from this study. It gives us some viable methods of enhancing, improving, or regaining our memory skills. (Consuming drinks spiked with glucose is not one of them, however! This would simply be treating a symptom instead of the cause of the problem. When you treat a symptom, without addressing the root of the problem, you only end up creating additional problems down the road.)
to take a good adrenal glandular supplement. The best Ive ever used is called Drenamin made by Standard Process Laboratories. Standard Process products are primarily sold through doctors, but you can also purchase them directly from Total Health Discount Vitamins at 800-283-2833 or www.totaldiscountvitamins.com. The normally recommended dosage for Drenamin is to chew one tablet, three times daily. Ive found better results from breaking the tablets in half and chewing half a tablet, six times a day on an empty stomach. Often, improvement will be seen in the first day or two; and as long as a proper diet is followed, the problem will be resolved within a month. Boosting adrenal function also requires eliminating mental, physical, and chemical stressors. Emotional stress, sugar, alcohol, and tobacco all place an unnecessary burden on the adrenals. (Five or ten years from now well probably read that an excess of these items has been linked to agerelated memory loss!) Finally, you must have adequate circulation to the brain. All the epinephrine and glucose in the world wont do much good if it cant reach your brain. As I mentioned earlier, in addition to Padma and/or ginkgo, one of the quickest ways to improve circulation everywhere in the body is exercise. A consistent walking program can make a world of difference. * * * As you can see, there are many things you can do to help prevent, treat, and, in the case of niacinamide, even reverse the memory loss caused by Alzheimers and other brain diseases. Although Alzheimers and memory loss are becoming increasingly common, they are not inevitable as you get older. There are several natural solutions for protecting and preserving your memory. By following the recommendations Ive outlined in this report, you can beat the odds and avoid the nightmare of Alzheimers or other brain impairments that destroy your memory and your life.
Publishers note: Dr. Williams works closely with Mountain Home Nutritionals, developing his unique formulations that supply many of the hard-to-find nutrients he recommends. The compensation he receives allows him to continue devoting his life to worldwide research and the development of innovative, effective health solutions.
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Before Quiz
INSTRUCTIONS: Grab a pencil! Then look at these 8 names and faces for about 5 seconds each. Turn to the next page to see how many you remember.
Larry
Joan
Don
Nancy
Phil
Sandy
Stan
Jane
Dave
Sue
Tom
Marilyn
Mike
Alice
Fred
Cathy
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Before Quiz
(continued)
Please write in all the names you remember. When youre done, flip back to see how many you got. (One point per name.)
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61-70 70+
Circle your Before score so you can easily compare it to your After score in a few weeks! Come back when youve followed my instructions on niacinamide for perhaps four weeks. At that time, you should notice an improvement in your score.
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_______ _______
_______
_______
_______
______
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_______
_______
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Scoring the After part: Again, give yourself a point for each correct name. Did your score improve by at least a point? If so, you just knocked ten years (more or less) off of your brain age! And youve hardly gotten started!
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Supplement to Alternatives
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ALT-OWRA-0908 932d070809