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Immunocal Frequently Asked Questions

by Steven P. Petrosino, Ph.D.

Q. What is bioactive whey protein? What is HMS?

A. We recommend Immunocal, a specific brand of bioactive whey protein (which is also called
Humanized Milk Serum or HMS-90 in Canada). This Bioactive Whey Protein is not a prescription drug,
but a powerful and unique patented (8 Method of Use Patents world-wide, and 5 US Patents) un-
denatured and highly bio-active whey protein dietary supplement that is loaded with glutathione
precursors. Immunocal bioactive whey protein took $10 million and 18 years of research to perfect.
The primary researcher involved in the discovery of bioactive whey protein is Gustavo Bounous, MD.
Bioactive whey protein is a highly concentrated milk serum isolate which is high in protein (90%
protein by weight) and is lactose-free, carbohydrate and sugar-free, and fat-free. Bioactive whey
protein shares many of the same immune promoting and enhancing properties of Mother's milk.
Bioactive whey protein has been clinically proven to increase serum and tissue glutathione levels, and
is validated by extensive research, including numerous published scientific studies and review articles
which appear in the medical literature and are available for you to examine through our MEDLINE
(National Library of medicine) link. Bioactive whey protein increases glutathione, which is your cells'
own natural antioxidant and most potent detoxifier. Bioactive whey protein has been demonstrated to
enhance both healthy and deficient immune systems, and is validated as an effective nutritional
supplement by the medical community. Bioactive whey protein is the only non-prescription dietary
supplement to appear in the year 2000 through 2005 Physician's Desk Reference (PDR) for Prescription
Drugs, although it is available without prescription! It has it's own NDC (National Drug Control)
number, and is reimbursable under Medicaid, Medicare, and by private insurance in many states.

Q. Is Bioactive whey protein approved by the FDA for the treatment of cancer, chronic
fatigue, autoimmune, and glutathione deficiency diseases?
A. No. The United States Food and Drug Administration (FDA) does not "approve" any nutritional
supplements for these indications. The FDA determines the safety of nutritional supplements, and
regulates or restricts the distribution of those products considered to pose a health risk to the American
public. Bioactive whey protein is considered to be "generally recognized as Safe", (GRAS) by the FDA.
This is the same classification given vitamin C. Based on a recent decision by the US Court of Appeals
for the District of Columbia Circuit, the FDA is tolerating references to certain therapeutic uses of
nutritional supplements which are based on strong scientific or clinical evidence and "significant
scientific agreement". Because bioactive whey protein is manufactured by a Canadian company, the
manufacturer is more sensitive to the regulatory pressures of the FDA than American supplement
manufacturers, and has chosen to be ultra-conservative in their marketing of the product. Each box of
the product is produced from 500 liters of fresh, organic milk from free-range, grass-fed cattle on a
contract farm in the state of Idaho. No disease treatment claims are made concerning bioactive whey
protein.

Q. What is the difference between bioactive whey protein and other whey proteins?
A. Bioactive whey protein has been shown to differ from other whey proteins in its effect upon the
immune system. Specifically, scientific studies on other whey proteins have not shown the same

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immune stimulating effects that are seen with bioactive whey protein. Bioactive whey protein is has
been extensively studied in the clinical literature. Comparing bioactive whey protein to other
commercial whey proteins clearly shows the superiority of bioactive whey protein. Immunocal bioactive
whey protein is a dietary supplement that is supported by eighteen years of research through rigorous
clinical trials that have been published in peer review journals. These studies, performed in world-
renowned medical and scientific institutions, attest to the quality and safety of bioactive whey proteins.
Bioactive whey protein studies have shown that they not only increase intracellular levels of GSH
(glutathione or glutathione precursors) following ingestion, but also significantly build up the stores of
these substances inside the cells. This beneficial effect lasts for considerable periods of time after
ingestion of bioactive whey protein.

Q. What is the product's bioactivity dependent upon?

A. Concentrations of 3 bioactive and thermolabile (easily damaged by heat) proteins that are
contained in the milk serum: serum albumin, alpha lactalbumin and lactoferrin. Because these
compounds can be damaged by heat (in excess of 140 degrees F) or excessive mechanical agitation,
bioactive whey protein must not be cooked, heated, or placed in a steel-bladed blender. For these
reasons, and to preserve the bioactivity of its serum albumin, alpha lactalbumin and lactoferrin,
bioactive whey protein has not been exposed to standard high-temperature Pasteurization. Rather, it
has been bio-filtered to remove bacteria, and subjected to patent-process low-temperature purification
procedures to ensure its safety and purity.

Q. If a different manufacturer of whey protein supplements was able to duplicate our

technology, could they make the same claims?
A. No. The power of our patents is not in manufacturing. Bioactive whey protein patents (presently
there are eight patents on bioactive whey protein: 5 US patents, and 3 international patents) relate to
the METHOD OF USE. That is, no other whey protein can state: "clinically PROVEN to stimulate the
immune system", and "significantly raises glutathione levels". Additionally, although there are dozens
of companies producing denatured (high-heat Pasteurized) whey proteins (primarily for use as a
protein source in body-building), there currently is no company manufacturing an UNDENATURED whey
protein product similar to bioactive whey protein. Numerous clinical studies and medical reviews
appear in the clinical literature which specifically involved bioactive whey protein, and not other high-
heat pasteurized commercial whey proteins. Accept no imitations.

Q. What exactly is glutathione and how is it important?

A. Glutathione is the master antioxidant of the body. Without glutathione, we die. The replenishment
of the glutathione levels within the lymphocytes (also called leucocytes or white blood cells) increases
the intensity of the immune response. The increase in glutathione levels also results in the proliferation
of lymphocytes that act as a scavengers, and helps to combat infections. Selenium (a micronutrient
and mineral) is a structural component of, and a co-factor for the antioxidant enzyme glutathione
peroxidase. For this reason, supplementation with selenium can modestly increase glutathione levels in
persons who are selenium deficient. Glutathione is a tri-peptide of the amino acids cysteine, glycine,
and glutamic acid. Tissue glutathione levels increase when cystine levels increase within the cell. This is
why cystine is critical in the production of glutathione, but prior to the development of bioactive whey
protein, no effective way was known to safely and significantly increase cystine levels in the cell over
long periods of time. A deficiency of glutathione can cause hemolysis (the destruction of red blood cells
resulting in severe anemia) and numerous diseases of oxidative stress. Low glutathione levels are
commonly found among the elderly, those undergoing cancer chemotherapy, and among patients
suffering from autoimmune and immune deficiency diseases such as rheumatoid arthritis, chronic
fatigue syndrome (CFSIDS), fibromyalgia, and AIDS. Glutathione is essential in intermediary
metabolism as a donor of sulfhydryl groups (which are essential for the detoxification of the liver). That
is why the only known "side effects" associated with bioactive whey protein supplementation are
associated with the beneficial detoxification which occurs as a result of improved liver function. The

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antioxidant enzyme glutathione peroxidase functions in the process of elimination of wastes from the
body. Glutathione works within the liver, lungs, colon, kidneys, and skin in the process of removing
toxic eliminating cellular metabolic wastes.

Q. What is the difference between products or pills that people use as supplements that are
labeled as "glutathione" or "cystine"?
A. Glutathione is produced within the cells (intra-cellularly). When taking a pill labeled "glutathione",
clinical and laboratory studies demonstrate that oral glutathione is NOT absorbed but will be eliminated
by the liver through the bile before ever reaching the systemic circulation (blood stream). Cystine is
not well absorbed when taken by mouth. Injectable glutathione also has limited benefits. It is unstable
in the blood stream. By the time it gets to the cell, much of it gets degraded, and much of this
remaining glutathione cannot effectively pass through the cell membrane.
Clinical studies have demonstrated that oral cystine supplementation (NAC or N Acetyl L-Cysteine) is
NOT effective in increasing cystine levels within the cell, and has also not been associated with
significant increases in glutathione levels within the cell. The three bioactive proteins supplied by
bioactive whey protein constitute a "natural delivery system" from these cystine precursors to the cell
(in order to facilitate clinically and statistically significant increases in glutathione levels in BOTH the
extracellular serum and intracellular tissues). Because bioactive whey protein provides the building
blocks for cystine, and these building blocks for cystine are easily transported inside the cell where
they can be quickly synthesized into glutathione, bioactive whey protein is therefore ideally suited to
increase glutathione levels within the cell.

Q. What is the difference between NAC (N Acetyl L-Cysteine) and bioactive whey protein?
A. N Acetyl L-Cysteine (NAC) is sulfur-containing (sulfhydryl) amino acid which is present in many
proteins, and is in the same class as the amino acid methionine. NAC is a naturally occurring amino
sugar and is a form of cysteine which has been demonstrated to facilitate the SHORT TERM cellular
detoxification of alcohol, tobacco smoke, acetaminophen [Tylenol®] poisoning and environmental
pollutants in several in vitro studies. When Cystine is heated, molecular bonds are cleaved and it
becomes Cysteine. Cysteine is beneficial if it is produced INSIDE the cell, but is mildly toxic if it is
produced outside the cell. NAC does not travel well in the blood stream, and doesn't reach the cells (to
be used to synthesize glutathione and Glutamic acid). NAC supplementation over long periods has been
associated with modest increases in serum glutathione, but has not proven particularly useful in the
treatment of chronic, long-term intracellular glutathione deficiencies. Furthermore, therapeutic levels of
NAC are relatively toxic and have been associated with significant side effects. At therapeutic doses,
oral NAC supplementation has been associated with cerebral symptoms, nausea, blurred vision, and
vomiting. Bioactive whey protein provides the precursors for the manufacture of intra-cellular cystine,
and effectively delivers these to the cell. For this reason, bioactive whey protein supplementation has
been associated with sustained and significant increases of cellular glutathione, and is virtually devoid
of troublesome side-effects. Bioactive whey protein has the same side-effect profile as mothers' milk.

Q. What is the difference between bovine colostrum and bioactive whey protein?
A. The proteins in colostrum have almost no cystine content. Cystine is critically essential to the
immune system. Although Growth Factors present in colostrum (including IGF-1, or Insulin-like growth
Factor-1 which is effective in promoting muscle growth) are not affected by stomach acid, research
published by one manufacturer of Colostrum (Vital Health News, Winter 1998, page 7) demonstrated
that "the effectiveness of the immune factors present in colostrum is lowered by stomach acid."
Although the immune enhancing factors found in colostrum are often "preferable to single isolated
immune components" (such as interferon, which is more likely to cause troublesome side effects),
colostrum has NOT been demonstrated to be superior to isolated undenatured whey proteins such as
bioactive whey protein. Colostrum (which is produced during the first 26 hours following birth by the
mammary glands) is primarily composed of immunoglobulin and some lactoferrin. According to both
laboratory experiments and clinical trials conducted in Germany, although colostrum supplementation

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was associated with mild increases in immune function in some patients, these increases were not
statistically significant, (p=ns). A postulated mechanism of action of colostrum is the inter-species
transfer of immune factors, however this has NOT been clinically proven. Most of the data supporting
the effectiveness of colostrum is anecdotal (consisting mostly of personal testimonies rather than
clinical studies). Since the primary mechanism of action on the immune system is via stimulation of the
synthesis (production) of glutathione, the near absence of glutathione precursors in the
immunoglobulin fraction (from the colostrum) may explain its relative lack of effect. Conversely,
bioactive whey protein contains substantial amounts of thermolabile (heat-sensitive) proteins that are
rich in cystine and glutamylcystine (known precursors of glutathione), and bioactive whey protein has
been validated in numerous human clinical trials which found statistically significant increases in
glutathione and indices of immune function (such as CD4:CD8 ratios). Colostrum might be beneficial as
an adjunctive (add-on) to bioactive whey protein, but the clinical data is significantly more convincing
for bioactive whey protein.

Q. How does the manufacturing of our product differ from other whey proteins?
A. In the manufacturing of other whey proteins several things occur: in the process of heating and
Pasteurization, critical bonds holding the cystine together get broken down ("denatured", meaning they
loose their original nature--similar to the denaturing and irreversible changing of liquid egg white by
the heating process involved in frying an egg). The exact type of proteins that serve to increase tissue
and serum glutathione most effectively are lost or diminished. Researchers have developed a process
by which these delicate proteins remain intact in their natural form to serve us most effectively.

Q. Is bioactive whey protein free from Bovine Growth Hormone, antibiotics, and other
chemicals?
A. rBGH (bovine Growth Hormone) and other growth hormones have become a major issue of
controversy in the dairy industry. Certain herdsmen give their cows the growth hormone to increase
milk production. It is devastating to the cows, and to those who drink their milk also. Canadian
manufacturers of bioactive whey protein receive all of their milk from one large dairy farm in the state
of Idaho. This particular location was chosen because the soil selenium levels are highest in the USA,
and grazing on grasses which are grown on Idaho selenium-rich soil results in high selenium levels in
the milk. Selenium (an essential micronutrient and mineral) is a structural component of the powerful
"master antioxidant" glutathione. The selenium level in 10 grams of bioactive whey protein is more
than 4 mcg, which is much higher than found in most commercial whey proteins. That is good. This
facilitates the cystine component of the whey protein (bioactive whey protein is 100% whey protein)
from this selenium-rich milk to be more effeciently metabolized by the body to form glutathione within
the cells of the body. On the other hand, absolutely no herbicides, pesticides or chemicals are used on
the grasses these cows graze upon. The milk from these cows is certified organic (hormone, pesticide
and agricultural chemical-free). The cattle on this farm are subjected to more rigorous standards than
almost any other dairy cattle in the USA. If a cow is sick and must be treated with antibiotics (or any
other pharmaceutical compound), it is removed from the herd and its milk is not used. Absolutely no
BGH or other hormone compounds are used on these cows.

Q. What are some additional benefits of whey proteins?

A. Bioactive whey protein has been clinically demonstrated to increase exercise capacity by 13 percent
(Lands et al., 1999), and may be useful as a supplement for competitive athletes. Wattanabe et al.
(Japan) conducted a clinical study with bioactive whey protein to evaluate increases in GSH among
patients with Hepatitis B and C, and found that these viruses are vulnerable to glutathione. In-vitro
studies in Japan also showed that whey can stimulate the bone cell (osteoblasts) to produce more
bone, hence increasing bone density and reducing the risk of osteoporosis. Lactalbumin from whey
protein has been demonstrated to kill breast cancer cells in vitro (in a test-tube). Glutathione (from
whey protein) lowers serum cholesterol by stimulating bile synthesis in the liver. In addition,
glutathione is a powerful antioxidant that will prevent lipid peroxidation (a sign of free radical activity).

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Lipid peroxidation is implicated in arteriosclerosis (hardening of the arteries), stroke and coronary
artery disease. Because neither bioactive whey protein nor glutathione is a drug, no disease treatment
claims can be made on the basis of these studies.

Q. What is the theoretical mechanism of action of GLUTATHIONE in Cancer and Immune

dysfunction?
A. Natural killer (Immune) cells may become glutathione-depleted over time, and immune response
weakens. Bioactive whey protein raises glutathione levels and strengthens the immune system. The
immuine system is the body's first line of defense against cancer, viruses, bacteria, etc. For those
patients receiving traditional medical therapy for their cancer, bioactive whey protein supplies
lactalbumin and has been clinically proven to raise glutathione levels. Glutathione and lactalbumin (a
component of bioactive whey protein) have been associated with the strengthening of healthy cells and
(paradoxically) the weakening of cancerous cells. In research conducted by C. Svanborg et al,
lactalbumin was associated with apoptosis (or the programmed death) of breast cancer cells.
Glutathione has been scientifically demonstrated to decrease cancerous cells' resistance to
chemotherapeutic drugs, while protecting healthy cells. This would theoretically allow a patient to
respond better to chemotherapy with less side effects. Because neither bioactive whey protein,
lactalbumin, nor glutathione is a drug, no disease treatment claims can be made on the basis of these
studies.

Q. What are the diseases or conditions that have been associated with low glutathione
levels?
A. Most of the autoimmune and degenerative diseases of aging including: Acetaminophen poisoning,
ADD, Addison's Disease, aging, AIDS, Alopecia Areata, ALS, Alzheimers' Disease, anemia (hemolytic),
Ankylosing Spondylitis, Arteriosclerosis (hardening of the arteries), arthritis (rheumatoid), asthma,
autism, autoimmune disease, Behcet's Disease, burns, cacexia, cancer, candida infection,
cardiomyopathy (idiopathic), Chronic Fatigue Syndrome, colitis, coronary artery disease, cystic fibrosis,
diabetes, Crohn's disease, eczema, emphysema, Epstein Barr Viral (EBV) syndrome, fibromyalgia, free
radical overload, Goodpasture Syndrome, Graves' Disease, hepatic dysfunction (liver disease), hepatitis
B, hepatitis C, hypercholesterolemia (high blood cholesterol), herpes, infections (viral, bacterial and
fungal), inflammatory bowel disease (IBD), lupus, macular degeneration (diabetic macular
degeneration), malnutrition, Meniere's disease, multiple sclerosis, Myasthenia Gravis,
neurodegenerative diseases, nutritional disorders, Parkinson's disease, Pemphigus Vulgaris, Primary
Biliary Cirrhosis, progeria, psoriasis, Rheumatic Fever, Sarcoidosis, scleroderma, shingles, stroke,
surgery, toxic poisoning, trauma, vasculitis, vitiligo, and Wegener's Granulomatosis. No disease
treatment claims can be made for glutathione on the basis of glutathione deficiency in these diseases.

Q. Has therapy to increase glutathione levels been effective in treating the diseases or
conditions that have been associated with low glutathione levels?
A. See: Medline Search Page. No disease treatment claims can be made for glutathione on the basis of
glutathione deficiency in these diseases.

Q. Can a person who is lactose intolerant take bioactive whey protein?

A. Yes, certain brands. A Canadian brand of bioactive whey protein has less than 1% lactose which
should not cause any ill effect even in the most severe case of lactose intolerance.

Q. Can a person who is intolerant of Monosodium Glutamate (MSG) take bioactive whey
protein?
A. Yes, bioactive whey protein has NO added MSG (trace amounts may occur naturally) which should
not cause any ill effect in people with an MSG intolerance. Bioactive whey protein contains the following
amount of glutamic acid by weight: 180 mg/gram. There is therefore 1.8 grams of glutamic acid in a
10 gram packet of bioactive whey protein. Every single protein on the earth contains glutamic acid, and

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glutamic acid is required for good health. Glutamic acid is an amino acid formed in the digestion of ALL
proteins (including wheat gluten and meat). It is the only amino acid metabolized by the brain.
Glutamic acid is necessary in human nutrition but can usually be manufactured by the body in
adequate amounts. That means that our own body produces it. In certain disease states, deficient diet,
malnutrition, and in certain metabolic abnormalities this amino acid becomes conditionally essential.
Glutamic Acid's sodium salt, is monosodium glutamate, and ALL proteins may contain naturally
occurring trace amounts of MSG. In summary, bioactive whey protein would not supply any more
glutamic acid than a serving of steak or other similar protein. There is NO added MSG in bioactive whey
protein, and its supplementation should not cause a medical problem in a persons sensitive to MSG.

Q. Are there any interactions known between supplements such as coenzyme Q-10,
antioxidant vitamins, or herbs and bioactive whey protein?
A. No, there are no known potential or reported interactions between bioactive whey protein and
nutritional supplements. In fact, bioactive whey protein increases glutathione levels, which helps to
improve the action of antioxidant vitamins (which are less effective if your glutathione levels are
impaired). For this reason, mega-doses of antioxidant vitamins (i.e. doses in excess of 10 times the
RDA of these vitamins) are not required or recommended if you are supplementing with bioactive whey
protein. As we age, our glutathione levels fall precipitously like a down-hill ski-slope. Low levels of
glutathione are associated with a host of degenerative diseases, and critically low levels of serum and
tissue glutathione often predict that death is imminent. Supplementation with bioactive whey protein
helps restore these precious glutathione levels, and helps the supplemental vitamins we are taking to
work more effectively to maintain optimum health! Because neither bioactive whey protein, nor
glutathione is a drug, no disease treatment claims can be made on the basis of these findings.

Q. Are there any interactions known between prescription medications and bioactive whey
protein?
A. No, there are no known interactions between bioactive whey protein and prescription drugs.
Bioactive whey protein is composed of the same basic proteins which are found in human breast milk,
and should be considered to be as safe to take as mothers' breast milk. Furthermore, bioactive whey
protein is 90% protein, and is one of the best sources of highly-absorbable protein on the planet.
Patients taking immunosuppressant drugs such as Cyclosporin® should consult their physician before
taking bioactive whey protein.

Q. Are there any side effects associated with bioactive whey protein?
A. Bioactive whey protein increases serum and liver glutathione levels. When liver glutathione levels
rise, the liver is able to more effectively detoxify the body (which is a beneficial function of bioactive
whey protein). Some people (especially those who have been exposed to high levels of environmental
toxins) may have a mild temporary reaction to these mobilized toxins as the liver is removing them
from storage in body fat. Typically, reducing the dose of bioactive whey protein will allow these
temporary side effects to quickly disappear. Bioactive whey protein is composed of the same basic
proteins that are found in human breast milk, and has the same side effect profile as mothers' breast
milk. Because bioactive whey protein is a milk protein, persons who are mildly allergic to milk proteins
may experience minor gastric distress from bioactive whey protein. This gastric distress usually
disappears if you reduce the dose. Persons with serious milk-protein allergies should not take bioactive
whey protein

Q. Can you overdose bioactive whey protein? Is there any potential for toxicity if you take
too much?
A. Your greatest risk is wasting your money if you take "too much" bioactive whey protein, since it is
relatively expensive. Scientific data suggests that there is limited benefit from exceeding 3 grams per
day (3 packets per day) of bioactive whey protein. Because our cells have an innate mechanism of
"feed-back inhibition" with respect to the glutathione synthesis precursors (building blocks) provided by

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bioactive whey protein, there is no potential for making "too much glutathione" within the cell if large
quantities of bioactive whey protein are consumed. Bioactive whey protein supplementation will result
in establishment of normal glutathione levels, (NOT excessive glutathione levels) within the cell. Excess
bioactive whey protein would be metabolized as protein (whey protein is an excellent source of protein,
containing 90% protein by dry weight).

Q. Because bioactive whey protein is 90% protein, is it contraindicated in patients on renal

dialysis who must limit protein intake?
A. No, bioactive whey protein is not contraindicated in these patients. Although we suggest that you
consult your personal physician with medical questions such as these, there is no reason to believe that
bioactive whey protein would be harmful in these patients. Bioactive whey protein is one of the most
easily digested and most easily absorbed forms of protein in the diet. Its Protein Efficiency Ratio (PER:
a mark of the quality of a protein) is extremely high, and in conditions such as renal failure where
protein intake must be limited, it is most prudent to consume the highest quality proteins such as whey
proteins and egg white proteins, versus lower quality proteins that produce more problematic metabolic
waste by-products and residues.

Q. Is bioactive whey protein contraindicated in Celiac Sprue disease?

A. No. These patients are usually instructed not ingest wheat or gluten. There is no wheat, or gluten
found naturally in bioactive whey protein. Furthermore, at least one brand of bioactive whey protein
(from a Canadian manufacturer) is lactose-free. There is no reason to believe that that bioactive whey
protein would be detrimental in patients with Celiac Sprue.

Q. Who should not take the product?

A. People with an allergy specifically to milk protein, (which is very rare). NOTE: Please understand
that lactose intolerance is NOT a milk allergy. Also, anyone who has had an organ transplant and is
receiving immunosuppressant therapy should not take bioactive whey protein unless instructed to do
so by his or her physician or another health care professional. The immune system needs to be
suppressed in order to prevent organ rejection, and bioactive whey protein may counteract
immunosuppressant medicines such as cyclosporin®.

Q. What are some of the critical ingredients in a daily amount of bioactive whey protein (1
pouch)?
A. 9 grams or 90% Protein, 0 Fat, less than 0% Lactose, 60 mg of Calcium, 4 micrograms of
Selenium, 30 Mg of Potassium, 0.05 mg of Iron, and approximately 40 Calories.

Q. What is the recommended dose for taking bioactive whey protein?

A. Check with your physician or health care professional. If you do not have a documented glutathione
deficiency and are taking bioactive whey protein to maintain good health, one pack per day is not
unreasonable. Generally, most studies conducted using bioactive whey protein in patients with
glutathione deficiencies used at least 20 grams per day (2 pouches), and some studies showed
increased effectiveness using up to 30 grams (3 pouches) per day. Most of our customers use 2 boxes
per month (this provides 2 pouches, or 20 grams per day per month).

Q. What is the recommended intake of protein for an average adult per day?

A. 50-60 grams of protein. Three packets of bioactive whey protein would provide 50% of this
recommended daily intake.

Q. What is the difference in taking bioactive whey protein as opposed to taking

antioxidants?
A. Vitamin E and C are important antioxidants, and you should consider these important supplements

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in your diet. Bioactive whey protein is not an antioxidant per se, but provides the building blocks for
the synthesis of glutathione, which is THE principle intra-cellular antioxidant. Glutathione is the most
potent cellular antioxidant known to man, and is hundreds of times more potent than vitamin C or
vitamin E. For this reason, glutathione has been called the "Super Antioxidant". By raising the
glutathione level within our bodies we provide for the optimum functioning of other lesser antioxidants
such as vitamins C and E. More importantly, glutathione serves as a detoxifying agent for multiple
toxins that we encounter on a daily basis through the environment and medications we are exposed to.
Glutathione has been demonstrated to act as an effective protectant against ultraviolet radiation, which
is important in view of the continued loss of the ozone layer.

Q. How much does bioactive whey protein cost?

A. Purchase bioactive whey protein for as little as $59.40/box.

Q. Is there a test to determine if my glutathione levels are low?

A. Yes. We know of a licensed laboratory that charges only $40 for this test. DISCLAIMER: We are
NOT associated with this laboratory, nor do we receive ANY reimbursement from recommending their
services.

Q. Is bioactive whey protein listed in the Physicians Desk Reference (PDR)?

A. Yes. A brand of bioactive whey protein produced from USA cow's milk and manufactured and
processed in Canada is the ONLY nutritional product sold by direct sales to be listed in the prestigious
PDR, which is also frequently called the "physician's bible", and is owned and consulted by virtually
every physician in the USA and world-wide! Physicians have relied on the PDR for up-to-date
information on prescription drugs for over 50 years. The PDR is considered the standard prescription
drug reference and is found in virtually every physician's office. Although this brand of bioactive whey
protein does NOT require a prescription, it's inclusion in the PDR is a result of recognition by the
medical community, of the extensive clinical data supporting it's effectiveness, and as a result of it's
recognition by Medicare and Medicaid as reimbursable. The publisher of the PDR, Medical Economics,
also produces a smaller companion volume for non-prescription drugs and herbal medicines. This
volume may contain references to other bioactive whey proteins and other nutritional supplements.

Q. Is bioactive whey protein reimbursed by Medicare, Medicaid and Private Insurance

programs?
A. Yes. Although Medicare and Medicaid do not endorse or "approve" any company's product, a
Canadian brand of bioactive whey protein meets the coding determination for coverage by Medicaid,
Medicare, and many private insurance programs. Although the purchase of bioactive whey protein does
not require a doctor's prescription, a prescription is required for reimbursement coverage under
Medicare and Medicaid. NOTE: The Canadian brand of bioactive whey protein is the FIRST product sold
by any direct selling company in the world to ever meet these strict criteria. This is a phenomenal
accomplishment for a non-drug "nutritional supplement", and clearly establishes a higher level of
validation and credibility for this product! The Canadian brand of bioactive whey protein has it's own
NDC (National Drug Control) registry number: 28770-0970-01, and is being approved on a state-by-
state basis for reimbursement. The code for Medicare is: B4155. Currently, Ohio, New Jersey,
Minnesota, Nevada, and New York have established reimbursement guidelines, and decisions in 18
states are currently pending. In some of these states (notably New York State and California), this
bioactive whey protein is available without restriction on Medicaid. In other states, the physician must
be willing to write a letter of necessity in addition to writing a prescription for it to be reimbursed. It
meets the requirements for enteral nutritional supplements which are covered by Medicare/Medicaid for
nutritional management of the patient. This is available for general practitioners to prescribe. For
Medicare patients, current coverage is limited to Naso-Gastric (NG) tube feedings, but Medicaid is
much less restrictive. Medicaid has broader prescribing parameters for both oral as well as tube-
feeding nutritional management. This Canadian brand of bioactive whey protein will be one of the few

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nutritional supplements to be listed in the year 2000 through 2005 edition of the prestigious Physicians'
Desk Reference (PDR). Physicians have relied on the PDR for up-to-date information on prescription
drugs for over 50 years. The PDR is considered the standard prescription drug reference and can be
found in virtually every physician's office, hospital, and pharmacy in the United States. The inclusion of
this product in the PDR is a reflection of it's credibility within the medical community, and is also a
result of our recognition by Medicare and Medicaid. For questions regarding reimbursement
procedures in your State, please contact your State office of Medicare or Medicaid, or
contact your private insurance plan provider directly.

Q. What is the best way to mix bioactive whey protein?

A. Because bioactive whey protein is a very fine and delicate powder, we recommend mixing it with
water or any juice or liquid that is not above lukewarm (less than 110 degrees F, and NEVER above
120 degrees F) temperature. First, mix the packet with approx. 1 tablespoon of the liquid you have
chosen to form a paste. Second, now pour the liquid to fill your glass. Allow it to sit for a few minutes,
stir, and enjoy. It can also be mixed in applesauce, yogurt, or sprinkled over cereal without any
particular mixing procedure. The product CANNOT be mixed in a blender (mechanical mixing damages
the milk proteins). You must stir by hand, or you can purchase an inexpensive "vortex-mixer". We will
ship you a portable, battery-operated vortex-mixer FREE with your first shipment of bioactive whey
protein on the Automatic Shipment program (when you sign up to receive bioactive whey protein using
your credit card to receive monthly shipments of one or more boxes).

The Chart below is the research by a M.D. Ph.D on over 15,000 consumers using Immunocal (also
called HMS-90 in Canada) over a 4 year period. Please note the high percentage of positive benefit for
many different health challenges. Immunocal works.

The average of those who experienced a benefit from Immunocal was 75%! The authors stated: "The
majority of the users who did not get optimal results failed to do so because they took a lesser dose
and/or took it a lesser amount of time than recommended."

Condition Total # % Helped

Allergy symptoms 1,875 88%
Arthritis 1,235 80%
Asthma 5,689 70%
Cancer 1,419 69%
CFIDS, Fibromyalgia 2,399 78%
Depression 1,111 77%
Diabetes, Types I and 2 4,232 84%
Digestion 2,392 90%
Energy, increased 12,199 90%
Heart Disease 1,643 78%
High Blood Pressure 1,411 85%
HIV, lessened symptoms 105 56%
Kidney Health, improved 2,838 67%
Menstruation symptoms 2,573 78%
Mental Acuity, alertness 3,844 74%
Multiple Sclerosis 17 51%
Muscle Mass Increase 933 71%
Obesity 4,181 71%

To get more information p.416.769.2971, immunotec@3web.com or www.immunotec.com/maktek

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Pain, including headaches 5,139 86%

Sexual Enhancement 2,276 85%
Sleep, improved 1,534 74%
Smoking 663 58%
Stress 5,156 72%
Stroke 1,391 55%
Well being 5,915 78%

(data on File, A. Somersall, MD, PhD)

Right now this natural health product is being studied in over 40 universities worldwide. Also, doctors
and researchers have conducted a number of studies on how this health product affects cancer.

To get more information p.416.769.2971, immunotec@3web.com or www.immunotec.com/maktek