THE BEST JUST GOT BETTER

Now only 6 capsules per day Superior ingredients Contains more effective antioxidants Reflects the latest research

OrthoCore

TM

AOR.ca

Before....
Fill weight per capsule Total number of capsules - Calcium D-Glucarate G - Chlorophyllin Complex - Trans-resveratrol - Indole-3-Carbinol (I3C) 3C - Sulforaphane (from Broccoli Sprout Extract) Vitamin A Complex - Retinol (palmitate) - Alpha-carotene - Beta-carotene - Cryptoxanthin - Lutein - Zeaxanthin B1 (Thiamin) B2 (Riboflavin) B3 (Niacin-as 126 mg Inositol Hexanicotinate) B5 (d-Ca Pantothenate) B6 (Pyridoxamine) B12 (Cyanocobalamin) Folic Acid Biotin Choline (Bitartrate) Inositol (from Inositol, Inositol Hexanicotinate) Vitamin C Complex - Vitamin C (Magnesium Ascorbate) - Mixed Citrus Bioflavonoids (25%) - Quercetin Dihydrate (85% Quercetin) Vitamin D3 (Cholecalciferol)

Serving Size:

9 Capsules

989 mg 270 15 mg 300 mg 1.8 mg 20 mg 7.1 mg

150 mcg/500 IU 1.6 mg/1332 IU 6.0 mg/9990 IU 30 mcg/25 IU 6.8 mg 364 mcg 9 mg 2.5 mg 115 mg 100 mg 25 mg 24 mcg 800 mcg 300 mcg 200 mg 100 mg 120 mg 100 mg 65 mg 25 mcg/1000 IU

Vitamin E Complex Tocopherols: 100 mg - alpha-tocopherol 15 mg/22 IU - beta-tocopherol 2 mg - gamma-tocopherol 60 mg - delta-tocopherol 24 mg Tocotrienols: 10 mg - alpha-tocotrienol 3 mg - beta-tocotrienol 0.3 mg - gamma-tocotrienol 6 mg - delta-tocotrienol 1.3 mg Menatetrenone (MK-4) 120 mcg Boron (Citrate) 1.8 mg G Calcium (Citrate-Malate, D-Glucarate) 300 mg Chromium (Picolinate) 100 mcg Copper (Citrate) 1.5 mg Iodine (Potassium Iodide) 150 mcg Magnesium (Aspartate, Oxide, Ascorbate, Chlorophyllin) 210 mg Manganese (Glycinate) 2.3 mg Molybdenum (Na Molybdate) 45 mcg 200 mcg Selenium (Se-Methylselenocysteine) M Silicon (Na Metasilicate) 50 mg Strontium 1.5 mg Vanadium (Citrate) 18 mcg Zinc (Citrate) 11 mg Acetic acid 100 mg Glycine 400 mg Taurine 500 mg N-Acetylcysteine (NAC) 200 mg

Removed:
Acetic acid Calcium D-Glucarate Glycine Indole-3-Carbinol (I3C) Taurine More effective ingredients replaced these deletions have

Modified dosages:
Boron - new Health Canada guidelines prohibit the addition of more than 700 mcg in multivitamins Choline - dose reduced from 200mg to 100mg based on new research Chlorophyllin Complex - from 300mg to 150mg Selenium - lowered dosage from 200mcg to 55mcg because the latest research suggests that amounts above 55mcg are of no additional benefit Silicon - dose reduced because lower amounts are sufficient to support bone health Zeaxanthin - dose was reduced due to the addition of astaxanthin and lycopene which complete the carotenoid complex

and After
Fill weight per capsule 823 mg Total number of capsules 180 - Chlorophyllin Complex 150 mg - Trans-resveratrol 1.8 mg 100 mg - Pomegranate extract (40% Ellagic Acid) - Sulforaphane (from Broccoli Sprout Extract) 7.1 mg Vitamin A Complex- Retinol (palmitate) 150 mcg/500 IU Natural-Source Mixed Carotenoids: - Alpha-carotene 1.6 mg /1332 IU - Beta-carotene 6.0 mg/9990 IU - Cryptoxanthin 300 mcg/250 IU - Lutein 6.8 mg - Zeaxanthin 314 mcg - Astaxanthin 2 mg - Lycopene 10 mg Vitamin B Complex - B1 (Thiamin) 9 mg - B2 (Riboflavin) 2.5 mg - B3 (Niacin-as 126 mg Inositol Hexanicotinate) 115 mg - B5 (d-Ca Pantothenate) 100 mg 100 mg - B6 (Pyridoxal-5'-phosphate) 5 p - B12 (Methylcobalamin) 647 mcg - Folic Acid 800 mcg - Biotin 300 mcg - Choline (Bitartrate) 100 mg - Inositol (from Inositol, Inositol Hexanicotinate) 100 mg Vitamin C Complex- Vitamin C (MagnesiumAscorbate) 120 mg - Mixed Citrus Bioflavonoids (25%) 100 mg - Quercetin Dihydrate (85% Quercetin) 76 mg Vitamin D3 (Cholecalciferol) 25 mcg/1000 IU

Serving Size:

6 Capsules

Vitamin E Complex Tocopherols: 100 mg - alpha-tocopherol 15 mg/22 IU - beta-tocopherol 2 mg - gamma-tocopherol 60 mg - delta-tocopherol 24 mg Tocotrienols: 10 mg - alpha-tocotrienol 3 mg - beta-tocotrienol 0.3 mg - gamma-tocotrienol 6 mg - delta-tocotrienol 1.3 mg Menatetrenone (MK-4) 120 mcg Boron (Citrate) 700 mcg C 300 mg Calcium (Calcium carbonate, Citrate-Malate, d-Ca Pantothenate) Chromium (Picolinate) 100 mcg Copper (Citrate) 1.5 mg Iodine (Potassium Iodide) 150 mcg Magnesium (Aspartate, Oxide, Ascorbate, Chlorophyllin) 210 mg Potassium (Chloride) 50 mg Manganese (Glycinate) 2.3 mg Molybdenum (Na Molybdate) 45 mcg Selenium (Se-Methylselenocysteine) M 55 mcg Silicon (Na Metasilicate) 25 mg Strontium (Citrate) 1.5 mg 18 mcg Vanadium (Picolinate) Zinc (Citrate) 11 mg R(+)-Lipoic Acid L 150 mg 30 mg Co-Enzyme Q10 (ubidecarenone) E Green Tea Extract (45% EgCG; 1% caffeine) 140 mg N-Acetylcysteine (NAC) 200 mg

R(+)-Lipoic Acid - a vital antioxidant capable of L normalizing blood sugar levels and supporting the nervous system Co-Enzyme Q10 - essential for the production of E cellular energy and needed for cardiac function Green Tea Extract - contains the equivalent of 10 cups of green tea per day, the amount shown to reduce the occurrence of cancer Lycopene - powerful antioxidant that helps to prevent prostate cancer and other forms of cancer Potassium - helps to maintain the normal function of the heart and nervous system Pomegranate extract - supports detoxification, normal cellular function and prevents DNA damage Astaxanthin - important carotenoid that prevents the oxidation of cellular membranes

Added:

Improved forms:
B6 as P-5-P the active coenzyme form of the vitamin , -the dosage has been increased to 100mg to reflect the latest research showing that 100mg is needed to prevent protein glycation B12 as methylcobalamin, the active from of the vitamin -the dosage has also been increased to 647mcg reflecting research showing that this amount is required to reverse vitamin B12 deficiency Vanadium picolinate - picolinate is a more bioavailable form of this mineral

OrthoCore

TM

We have reached a stage where the consumption of a daily multivitamin for optimal health has become all but incontestable. However, there is a distinction between nutritional deficiencies and nutritional imbalances, and this distinction is critical.

Deficiencies vs. Imbalances

It is well-known that the 'modern' diet is rampantly deficient in essential nutrients. The need to redress these deficiencies has necessitated the use of multivitamin formulations, and these formulations react to perceived deficiencies. If a study suggests we are not getting enough Vitamin A, supplement manufacturers will often add an arbitrarily large amount of Vitamin A to their multivitamin formulations. However, while adequate Vitamin A supports vision, too much weakens bones. If another study emphasizes the importance of zinc, large amounts of zinc might be added in similar fashion. While this might make some short-term sense, it does not take into account that all nutrients work together and in synergy. For example, zinc depends on copper for optimum utilization, preferably in a 10 to 1 ratio. Therefore, any supplement manufacturer who adds more zinc to their multivitamin formulation will have to increase copper content proportionately. Failure to do so will result in an imbalance of this important ratio, leading to the suppression of copper-based antioxidant enzymes. Another example are the B-complex vitamins contained in multivitamin/multimineral formulations. It is usually the same 50 or 100 milligrams for each and every B vitamin (except for folic acid). What are the chances of the body needing precisely the same amounts of half a dozen different B vitamins, each with its own biological role to play?

Quality vs. Quantity

The imbalance created by adding disproportionate amounts of certain nutrients is compounded by the fact that the composition of those nutrients is simply not scientifically determined. An excellent example is Vitamin E, which in fact is not a lone vitamin but actually a complex of eight different molecules, each with specific roles that interact synergistically. Most supplements contain only one type of vitamin E molecule: alpha-tocopherol, which actually lowers the levels of the other E molecules. The most common E molecule in food (and in OrthoCore), is gamma-tocopherol. New evidence suggests that gamma-tocopherol, far more than alpha-tocopherol, could yield remarkable results against cancer, heart disease, and Alzheimer's disease.

Enter the Core

It was precisely the imbalances of this "mega-dose and hope for the best" archetype that led scientists at Advanced Orthomolecular Research (AOR) to develop OrthoCore. OrthoCore sets itself apart from other multivitamin/multimineral formulations in two ways: the first is that it does not concern itself with mega-doses. Instead, it pays extraordinary attention to balancing ratios of essential nutrients with one another in order to achieve a synergistic result. Secondly, it pays meticulous attention to combining diversely superior sources of those essential nutrients and balancing their ratios for optimal synergy as well. The latter has served as the focal point for the reformulation of OrthoCore.

The Best Just Got Better A Lot Better

Diverse superiority is an excellent way to describe the latest improvements in the newly reformulated OrthoCore - starting with the addition of astaxanthin to OrthoCore's carotenoid complex. Astaxanthin is 550 times more potent than Vitamin E in protecting the cell membrane from oxidative degradation, and 40 times more effective than beta-carotene at quenching singlet oxygen free radicals. R(+)-lipoic acid and co-enzyme Q10 are two more additions, ones that have long been part of the standard regimens of those truly determined to take charge of their own health. These enhancers of the mitochondria (the 'powerhouse' of the cell) have never been part of a comprehensive multivitamin formulation before - until now. These highly active nutrients also work synergistically with vitamins C and E, as well as n-acetylcysteine, or NAC, all of which are included in OrthoCore. Green tea extract is also included in the reformulated OrthoCore, and is standardized for an impressive 45% epigallocatechin gallate (EgCG), the key phytonutrient in green tea that is attributed to low cancer rates among consumers of green tea. Finally, pomegranate extract has also been added due to its uniquely potent ability to protect cellular health and DNA integrity. Balance and diversity. Comprehensiveness and potency. These have always been the guiding principles behind OrthoCore, ones that culminated in the development of the multivitamin of multivitamins.

Advanced Orthomolecular Research

www.aor.ca

Innovative Research & Scientific Integrity

AOR 9 - 4101 19th Street NE, Calgary, Alberta T2E 6X8 Canada