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Nr. 1.

Drug Abacavir3

Therapeutic Area Antivirals Psychiatry

2. 3. 4.

Aripiprazole4

Arsenic Trioxide5 Oncology

Atomoxetine6 5. Atorvastatin7

Psychiatry

Metabolic and Endocrinology

6. Azathioprine8 Rheumatology

7. 8. 9. 10.

Boceprevir9 Brentuximab Vedotin10 Busulfan11 Capecitabine12

Antivirals Oncology Oncology Oncology

11. 12. 13. 14.

Carbamazepine13 Neurology Carisoprodol14 Carvedilol15 Musculoskeletal Cardiovascular

Celecoxib16 15. Cetuximab (1)17

Analgesics Oncology

Label Sections Boxed Warning, Contradindications, HLA-B*5701 Warnings and Precautions, Patient Counseling Information CYP2D6 Clinical Pharmacology Boxed Warning, Clinical PML/RAR Pharmacology, Indications and Usage, Warnings Dosage and Administration, Warnings CYP2D6 and Precautions, Drug Interactions, Clinical Pharmacology Indications and Usage, Dosage and Administration, Warnings LDL receptor and Precautions, Clinical Pharmacology, Clinical Studies Dosage and Administration, Warnings and Precautions, Drug TPMT Interactions, Adverse Reactions, Clinical Pharmacology IL28B Clinical Pharmacology Indications and Usage, CD30 Description, Clinical Pharmacology Ph Clinical Studies Chromosome Contraindications, DPD Precautions, Patient Information Boxed Warning, Warnings HLA-B*1502 and Precautions Clinical Pharmacology, CYP2C9 Special Populations Drug Interactions, Clinical CYP2D6 Pharmacology Dosage and Administration, Drug CYP2C9 Interactions, Use in Specific Populations, Clinical Pharmacology EGFR Indications and Usage,

Biomarker

Nr.

Drug

Therapeutic Area

Biomarker

16. Cetuximab (2)18 17. Cevimeline19 Oncology Dermatology and Dental KRAS CYP2D6 CYP2D6 G6PD CYP2C19 CYP2D6 CYP2C19 Rh genotype CYP2D6 CYP2C19

Label Sections Warnings and Precautions, Description, Clinical Pharmacology, Clinical Studies Indications and Usage, Clinical Pharmacology, Clinical Studies Drug Interactions Precautions Precautions Drug Interactions, Warnings Drug Interactions Clinical Pharmacology, Dosage and Administration, Use in Specific Populations Precautions Drug Interactions Boxed Warning, Dosage and Administration, Warnings and Precautions, Drug Interactions, Clinical Pharmacology Drug Interactions, Clinical Pharmacology Warnings and Precautions, Use in Specific Populations, Clinical Pharmacology Indications and Usage, Warnings and Precautions, Adverse Reactions, Clinical Pharmacology, Clinical Studies Indications and Usage, Precautions, Adverse Reactions, Patient Counseling Information Indications and Usage, Clinical Studies, Patient Counseling Information Drug Interactions

18. Chlordiazepoxide and Psychiatry Amitriptyline20 19. Chloroquine21 Antiinfectives 20. Citalopram (1)22 Psychiatry 21. Citalopram (2)23 22. Clobazam24 23. Clomiphene25 Psychiatry Neurology Reproductive and Urologic Psychiatry Cardiovascular

24. Clomipramine26 25. Clopidogrel27 26. 27. Codeine29 28. Crizotinib30 29. Dapsone31 30. Dasatinib32 31. Desipramine33

Clozapine28

Psychiatry Analgesics

CYP2D6 CYP2D6

Oncology

ALK

Dermatology and Dental Oncology Psychiatry

G6PD Ph Chromosome CYP2D6

Nr. Drug Therapeutic Area 32. Desloratadine and Allergy Pseudoephedrine34 33. Dexlansoprazole Gastroenterology (1)35 34. Dexlansoprazole Gastroenterology (2)36 35. Dextromethorphan Neurology and Quinidine37 36. Diazepam38 Psychiatry 37. Doxepin39 38. Drospirenone and Ethinyl Estradiol40 39. Erlotinib41 40. Esomeprazole42 41. 42. Fluorouracil43 Fluoxetine44 Psychiatry Reproductive Oncology Gastroenterology Dermatology and Dental Psychiatry Psychiatry Rheumatology

Biomarker CYP2D6 CYP2C19 CYP1A2 CYP2D6 CYP2C19 CYP2D6 CYP2C19 EGFR CYP2C19 DPD CYP2D6 CYP2D6 CYP2C9 CYP2C9 CYP2C19 CYP2D6 ER receptor CYP2D6 CYP2D6 EGFR

Label Sections Clinical Pharmacology Clinical Pharmacology, Drug Interactions Clinical Pharmacology Clinical Pharmacology, Warnings and Precautions Drug Interactions, Clinical Pharmacology Precautions Precautions, Drug Interactions Clinical Pharmacology Drug Interactions, Clinical Pharmacology Contraindications, Warnings Warnings, Precautions, Clinical Pharmacology Drug Interactions, Clinical Pharmacology Clinical Pharmacology, Special Populations Drug Interactions Drug Interactions Drug Interactions Indications and Usage, Patient Counseling Information Special Populations Drug Interactions Clinical Pharmacology Clinical Pharmacology, Dosage and Administration, Drug Interactions, Specific Populations, Warnings and Precautions Indications and Usage, Dosage and Administration Clinical Pharmacology, Clinical Studies Indications and Usage, Dosage and Administration, Clinical

43. Fluoxetine and Olanzapine45 44. Flurbiprofen46

45. Fluvoxamine (1)47 Psychiatry 46. Fluvoxamine (2)48 Psychiatry 47. Fluvoxamine (3)49 Psychiatry 48. Fulvestrant50 Oncology 49. Galantamine51 50. Gefitinib (1)52 51. Gefitinib (2)53 52. Iloperidone54 Neurology Oncology Oncology

Psychiatry

CYP2D6

53. Imatinib (1)55 54. Imatinib (2)56 Oncology Oncology C-Kit Ph Chromosome

Nr.

Drug

Therapeutic Area

Biomarker

55. Imatinib (3)57 56. Imatinib (4)58 57. Imipramine59 58. Irinotecan60 59. Isosorbide and Hydralazine61 60. Lapatinib62 61. 62. Maraviroc64 63. Mercaptopurine65 Oncology Antivirals Lenalidomide63 Oncology Psychiatry Oncology Cardiovascular Oncology Hematology FIP1L1PDGFR CYP2D6 UGT1A1 Oncology PDGFR

Label Sections Pharmacology, Clinical Studies Indications and Usage, Dosage and Administration, Clincal Studies Indications and Usage, Dosage and Administration, Clinical Studies Drug Interactions Dosage and Administration, Warnings, Clinical Pharmacology

NAT1; NAT2 Clinical Pharmacology Indications and Usage, Clinical Pharmacology, Her2/neu Patient Counseling Information 5q Boxed Warning, Chromosome Indications and Usage Indications and Usage, Warnings and Precautions, CCR5 Clinical Pharmacology, Clinical Studies, Patient Counseling Information Dosage and Administration, Contraindications, TPMT Precautions, Adverse Reactions, Clinical Pharmacology Precautions, Clinical CYP2D6 Pharmacology CYP2C19 Drug Interactions CYP2D6 Drug Interactions Clinical Pharmacology, Cholinesterase Special Populations, gene Precautions, Warnings CYP2D6 Drug Interactions Drug Interactions, Clinical CYP2C19 Pharmacology Indications and Usage, Ph Patient Counseling Chromosome Information UGT1A1 Warnings and Precautions,

64.

Metoprolol66

Cardiovascular Psychiatry Psychiatry Musculoskeletal Psychiatry Antivirals Oncology Oncology

65. Modafinil (1)67 66. Modafinil (2)68 67. Mivacurium69 68. Nefazodone70 69. Nelfinavir71 70. Nilotinib (1)72 71. Nilotinib (2)73

Nr.

Drug

Therapeutic Area Psychiatry

Biomarker CYP2D6 EGFR

72. Nortriptyline74 73.

Panitumumab (1)75 Oncology 74. Panitumumab (2)76 Oncology 75. Pantoprazole77 76. Paroxetine78 Gastroenterology Psychiatry

KRAS CYP2C19 CYP2D6 IL28B CYP2D6 CYP2D6

Label Sections Clinical Pharmacology Drug Interactions Indications and Usage, Warnings and Precautions, Clinical Pharmacology, Clinical Studies Indications and Usage, Clinical Pharmacology, Clinical Studies Clinical Pharmacology, Drug Interactions, Special Populations Clinical Pharmacology, Drug Interactions Clinical Pharmacology Clinical Pharmacology, Drug Interactions Warnings, Precautions, Contraindications, Dosage and Administration Use in Specific Populations, Clinical Pharmacology, Clinical Studies

77. Peginterferon alfaAntivirals 2b79 78. Perphenazine80 Psychiatry 79. Pimozide81 80. Prasugrel82 81. Pravastatin83 Cardiovascular Cardiovascular Psychiatry

CYP2C19

82. Propafenone84 83. Propranolol85 84. Protriptyline86 85. Quinidine87 86. Rabeprazole88 87. Rasburicase89

Cardiovascular Cardiovascular Psychiatry Antiarrhythmics Gastroenterology Oncology Antiinfectives Psychiatry Gastroenterology

Genotype E2/E2 and Fredrickson Clinical Studies Type III dysbetalipoprot einemia CYP2D6 Clinical Pharmacology Precautions, Drug CYP2D6 Interactions, Clinical Pharmacology CYP2D6 Precautions CYP2D6 Precautions Drug Interactions, Clinical CYP2C19 Pharmacology Boxed Warning, G6PD Contraindications NAT1; NAT2 CYP2D6 Adverse Reactions, Clinical Pharmacology

88. Rifampin, Isoniazid, and Pyrazinamide90 89. Risperidone91 90. Sodium

Drug Interactions, Clinical Pharmacology UCD (NAGS; Indications and Usage,

Nr.

Drug Phenylacetate and Sodium Benzoate92 Sodium Phenylbutyrate93

Therapeutic Area

91. Gastroenterology

Biomarker CPS; ASS; OTC; ASL; ARG) UCD (NAGS; CPS; ASS; OTC; ASL; ARG) ER receptor IL28B CYP2D6 CYP2D6 TPMT CYP2D6 CYP2C19 CYP2D6 CYP2D6

Label Sections Description, Clinical Pharmacology Indications and Usage, Dosage and Administration, Nutritional Management Indications and Usage, Precautions, Medication Guide Clinical Pharmacology Drug Interactions Dosage and Administration, Warnings, Clinical Pharmacology Dosage and Administration, Precautions, Warnings Precautions, Warnings, Contraindications Clinical Studies Clinical Pharmacology Clinical Pharmacology

92. Tamoxifen94 93. Telaprevir95 94. Terbinafine96 95. Tetrabenazine97 96. Thioguanine98 97. Thioridazine99 Oncology Psychiatry Cardiovascular Opththalmology Pulmonary Reproductive and Urologic Oncology Antivirals Antifungals Neurology

98. Ticagrelor100 99. Timolol101 100 Tiotropium102 . 101 . Tolterodine103

102 Tositumomab104 Oncology . 103 Tramadol and Analgesics . Acetaminophen105 104 . Trastuzumab106 Oncology 105 . Tretinoin107 106 Trimipramine108 . 107 . Valproic Acid109 108 Vemurafenib110 . Dermatology and Dental Psychiatry Psychiatry Oncology

Clinical Pharmacology, CYP2D6 Drug Interactions, Warnings and Precautions Indications and Usage, CD20 antigen Clinical Pharmacology CYP2D6 Her2/neu PML/RAR CYP2D6 UCD (NAGS; CPS; ASS; OTC; ASL; ARG) BRAF Clinical Pharmacology Indications and Usage, Precautions, Clinical Pharmacology Boxed Warning, Dosage and Administration, Precautions Drug Interactions Contraindications, Precautions, Adverse Reactions Indications and Usage, Warning and Precautions, Clinical Pharmacology, Clinical Studies, Patient

Nr.

Drug

Therapeutic Area Psychiatry Antifungals Hematology

Biomarker CYP2D6 CYP2C19 CYP2C9

Label Sections Counseling Information Drug Interactions Clinical Pharmacology, Drug Interactions Dosage and Administration, Precautions, Clinical Pharmacology Dosage and Administration, Precautions, Clinical Pharmacology

109 Venlafaxine111 . 110 Voriconazole112 . 111 . Warfarin (1)113 112 .

Warfarin (2)114

Hematology

VKORC1