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XIAOGUANG (Peter) LIANG 305 Anthony CT.

North Wales, PA19454 Phone: (267) 304-7252 E-mail: OBJECTIVE Seeking a Sr. Technician Position SUMMARY A successful research with over 20 years of progressively responsible and diver se experience gained in preventing and treating orthopedic defect, osteoporosis and osteoarthritis. Broad background in medical sciences, clinical experiences a nd methodologies in biology research field. Particular expertise in: Bone Etiology and pathogenesis In vivo small animal models Histology and Bone h istomorphometry Bone mechanical test Bone densitometry Animal surgeon Non human primate models ELISA experience` EDUCATION 1977 - 1982 Bachelor degree of Medicine, Guangdong Medical College, the People's Republic o f China. 1991 - 1994 Postdoctoral Training, Laboratory of Bone Biology and Histomorphometry, Division of Radiobiology, School of Medicine, University of Utah. PROFESSIONAL EXPERIENCE 2008 - Present Principle research scientist Pharmalegacy Laboratories of Shanghai, China In charge of Pathology department that includes histology, histopathology, histo morphometry, bone densitometry, bone mechanical test, animal surgery and the dev elopment of the animal models such as OVX, ORX, osteotomy, closed fracture and c ollagen induces arthritis (CIA) models in rodents and non human primates 1997 - 2008 Research Scientist GlaxoSmithKline, Immuno Inflammation CEDD, Translational Bio logy. Involved in establishing models of innate immunity in the mouse and rat. Had pre viously been involved in the design and testing of several different compounds f or treating osteoporosis and osteoarthritis in animal models 1994 - 1997 Research Scientist Regional Bone Center, Helen Hayes Hospital, Affiliated with Columbia- Presbyterian Medical Center, College of Physicians and Surgeons, Colum bia University. Developed in vivo small animal models of osteoporosis induced by estrogen defici ency (ovariectomy), by orchidectomy, and/or by immobilization (taping, tenotomy and sciatic) to study bone modeling and remodeling (bone mass, structural archit ecture and cellular based bone metabolism) in the seventh year of a 10 year Spec ialized Center of Research (SCOR) grant, awarded by the National Institutes of H ealth. Analyzed the mechanisms of bone loss, prevention, and restoration of bone mass b y various techniques including bone histomorphometry, bone densitometry (DEXA an

d PQCT) and mechanical strength testing. Focused on applying both anabolic agents (prostaglandin E2 and parathyroid hormo ne) and anti-resorption agents (estrogen and flurbiprofen est.) to prevent bone loss and/or restore osteopenic skeletons in above animal models. Involved in human biopsy histology and histomorphometry program. 1991 - 1994 Postdoctoral Fellow, Bone Biology and Histomorphometry Division of Radiobiology , School of Medicine, University of Utah. Learned the basic knowledge of bone biology, the pathogeneses and the progressio n of osteoporosis, the key concepts for the prevention and treatment of osteopor osis, the tools (bone knowledge, animal models, histomorphometric analysis) for studying etiology and therapeutic effects of various drugs in prevention and tre atment of osteoporosis. 1987 - 1991 Staff Physician, Neurology Department in First People's Hospital, Shaoguan City , Guangdong Province, the People's Republic of China. 1985 - 1986 Chief Resident, Department of Neuropathy, Zhujiang Hospital, Guangzhou, the Peo ple's Republic of China. 1982 - 1985 Resident, Department of Internal Medicine, First People's Hospital, Shaoguan Ci ty, Guangdong Province, the People's Republic of China. SCIENTIFIC TECHNICAL SKILLS Designing and conducting experiments to study the drug effects on the skeleton in animal models of osteoporosis. * Animal: animal care, treatment (injection, gavage and implant) and necropsy. * Animal surgery, femoral closed bone fracture, osteotomy, bone defect, ovariec tomy, orchidectomy, tenotomy, sciatic neurotomy and hind limb immobilization, pe riodontitis induced by ligature of the mandibular molar, marrow infusion model i n rats using Alzet pumps as drug delivery system, spinal fusion, osteoarthritis in surgical model involves transection of the anterior cruciate ligament (ACL), model for in vivo study of inter-vertebral disc degeneration and regeneration an d implanted with sterilized bioglass material into one side of the distal femora l transcondyle drill-hole defects * Establishment of the animal modes of non human primate osteotomy and collagen induces arthritis (CIA) models * Bone mass measurement: Single photon absorptiometry (SPA), Quantitative Compu ted Tomography (QCT), Dual Energy X-Ray Absorptiometry (DEXA) and micro-CT. * Histomorphometry: undecalcified and decalcified bone specimen preparation (fi xation, staining embedding, sectioning, microradiographing, osteoclast and osteo blast counting, trabeculae, cortical bone and sub-chondral bone static and dynam ic parameters. * Mechanical test on bone (indentation test of cancellous bone, compress test o f lumber vertebrae and three point bending of long bone) with MTS machine. * Image analysis, photography and graphing. * ELISA biochemical analysis * Visiopharm automated system application * Bone and cartilage biochemical markers of several species analysis. * Data analysis: Data organization, statistical analysis by SAS or Steview pack age and report writing. * Preparation and submission of scientific manuscript base on research conducte d. * Computing experience: Extensive experience in software handling and conversin g fortran, basic, graphics, word processing and imagine analysis systems in both

PC and Macintosh operating systems. * Efficiently report experimental results in eLNBs