Lawrence Porco PO Box 1019 Bronx, NY 10462 lp15db174@westpost.net 2003-present NYC Transit, Brooklyn, N.Y.

Rapid Transit Operations Operate subway trains as a Motorman in revenue and non-revenue service in the IR T Division. Took this job due to a 9-month layoff from pharma industry with no prospects for employment. Would consider another permanent CRA position again. 2002-03 Barton & Polansky Associates, NYC, N.Y. Layoff Division of ICON Clinical Research Clinical Research Associate as In-House Monitor a Worked on Phase IIIb/Expanded Access anti-HIV study enrolling patients (5 pts /site;40 sites). a Made monitoring calls in lieu of actual site visits; reviewed regulatory docu ments for accuracy; wrote monitoring call reports, also confirmation and f ollow-up letters to the site; on behalf of site requested exemptions from sponso r for patient enrollment and reported protocol deviations/violations to sponsor; followed patient SAEs obtaining discharge summaries, labs. 2001-02 Ingenix Pharmaceutical Services, Basking Ridge, N.J. Clinical Research Associate as In-House Monitor a Worked on Phase III, IV, and Expanded Access anti-HIV studies. a Coordinated patient enrollment based on inclusion/exclusion criteria; generat ed queries to investigators; interfaced between study sites and sponsors; issued regulatory documents; proofread protocols, case report forms, investigator agre ements, informed consents. Feb a01Purdue Pharma, L.P.; Stamford, CT. Aug a01 Regulatory Affairs Associate in International Reg. Affairs Temp. Provided assistance to the Drug Safety, Labeling, & Biostatistics Dept s. a Responded to inquiries from various overseas affiliates requesting drug produ ct registration information. Prepared and supplied CMC data and inform ation for annual reports. a Organized patient files and sorted them by adverse events in drug safety. a Maintained labeling inventory database entering and issuing labels, container s, and patient inserts. Proofread labeling corrections and obtai ned approval signatures. a Reviewed and compiled statistical doc. notebooks for 4 drugs to comply with d ept. SOP. July a00Regeneron Pharmaceuticals, Inc.; Tarrytown, N.Y. Nov a00 Research Associate in Pharmacokinetics/Transgenic Mice Grou ps Temp. a Performed PK studies with rats and mice (dosing and canula/tail bleeds) involving anti-cancer and anti-obesity test compounds. a Collected the serum and analyzed via ELISA. a Worked in the mouse transgenic group utilizing embryonic stem cells, PCR, and Southern blots to study knockouts to identify various gene functions. 1999 - 2000 Bronx Veterans Administration Hospital Laboratory; The Bronx, N.Y. Clinical Laboratory Technologist in Chemistry, Hematology, and Blood Bank Issued blood component units upon request and analyzed blood/urine in chem. and hem. depts. 1998 Lederle Laboratories (Wyeth-Ayerst Research); Pearl River, N.Y. Temp. Drug Safety and Metabolism Chemist in Drug Disposition Department a Performed pharmacokinetic studies measuring via Packard automated tissue oxid izer and scintillation counter novel carbon-14 labelled compounds dis tributed in animal tissues. a Extracted cold test compo

und metabolites from various animal plasmas preparing them for HPLC and LC/MS an alyses. a Kept updated study logbooks and interfaced with other departments concerni ng studies. 1991 - 1998 U.S. Customs Service Laboratory; New York, N.Y. Regulatory Analytical Chemist in Chemicals Branch a Analyzed smuggled narcotics for interdiction & imported legal commodities for tariff purposes. a Wrote many management briefs informing the US Customs Lab Director and other Government personnel of outstanding monetary (tariff) changes in imported goods upon sample testing completion and other noteworthy items of analytical interest . a Worked as part of a narcotics destruction committee at the US Custom Service Lab which oversaw the random drug analysis of narcotics and their disposal via i ncineration. a Involved with the US Customs Lab Open House demonstrations of the analytical instrumentation and methods of analysis used for the study of imported products to the private industry, the public, and other government personnel with in-hous e activities and outside mobile lab fairs. a Demonstrated to other US Customs personnel the use of the preliminary narcoti cs test kits used by field agents. 1984 - 1985 Ayerst Laboratory; New York, N.Y. Medical Research Associate in Bioavailability (Phase I) Group a Worked in the Bioavailability Phase I group in the areas of oncology and endoc rinology. a Organized Phase I studies for transdermal patch tests of a steroid compound. a Traveled to various domestic sites to monitor clinical drug trials. EXPERIENCE: Clinical Research a Involved with Phase I studies for transdermal patch testing. Traveled with exp erienced monitors to various domestic sites and observed the study while it was being conducted. a Compared data in the Case Report Form against the medical record to validate t he data. a Reviewed the medical records to ensure all adverse experiences were recorded o n the Case Report Form and appropriately reported. a Reviewed the documentation included in the siteas study file. a Participated in Interim Monitoring Visits. a Reviewed informed consents, study protocols, investigator agreements, and CRFs as well as patient lab reports for inclusion/exclusion criteria for study enrol lment. a Used Siebelas eClinical as the remote data capture software and worked with Do cumentum. Therapeutic Areas a Oncology: Performed tumor implantation and transfers in rats and nude mice mo dels. Isolated human megakaryocytes and studied their cell surface proteins for cancer markers. a Hormonal biochemistry: Studies methods for early detection of breast cancer. a Molecular Biology: Studied 3T3 fibroblast cell transformation by modified Mol oney MLV with Abelson genome measured by tyrosine kinase activity. a Hematology, Clinical Chemistry, and Urinalysis: Interpreted qualitative and q uantitative values for clinical chemistry tests and reported these results and i

nterpretations to appropriate hospital staff. Performed emergency blood and uri ne drug test analyses for local hospitals. Worked in the Blood Bank to type and crossmatch patient samples and issue blood components. a Pharmacokinetics: Performed pharmacokinetic studies measuring carbon-14 label ed compounds distributed in animal tissues. Extracted cold test compound metabo lites from various animal plasmas in preparation for analysis. Oral and Written Communications a Assisted in the writing of Standard Operating Procedures (SOPs) for a variety of lab equipment. a Wrote SOPs for Narcotics handling concerning their acceptance, storage, analys es, chain-of-custody, and disposal in the lab. a Wrote many management briefs informing the US Customs Lab Director and other G overnment personnel of outstanding monetary (tariff) changes in imported goods u pon sample testing completion and other noteworthy items of analytical interest. Computer skills a Microsoft Access, Excel, Word, Outlook; Lotus Notes LICENSES: New York City Department of Health Clinical Laboratory Supervisor: Area 33C a" Forensic Toxicology Clinical Laboratory Technologist: Area 30 a" Therapeutic Substance Monitoring / Quantitative Toxicology Area 33 a" Drug Analysis: Qualitative (Routine) Area 33A a" Emergency Toxicology Area 33C a" Forensic Toxicology EDUCATION: M.S. in Pharmacology/Toxicology St. Johnas University Jamaica, N.Y. M.S. in Biology (Cytogenetics) Fordham University The Bronx, N.Y. B.S. in Biology (Pre-Med) Fordham University The Bronx, N.Y. HONORS AND AWARDS: a U.S. Customs monetary award for updating narcotics inventory and assisting the Petroleum Chemist in inspecting private gauging laboratories. a Member of Rho Chi Honor Society with 8 straight A's in graduate courses (St. J ohn's Univ.). a Made the Dean's List with a GPA 3.5 or higher (Fordham University graduate pro gram).