Pharma Analysis | PharmaTutor

http://www.pharmatutor.org/pharma-analysis

Home

Pharma News

Career Watch

Jobs

Exam alerts

Scholarship

FAQ

Subscribe

Search

PharmaTutor
Pharmacy Infopedia

Vacancies

Pharm apedia

Art icles

Projects

PharmaQuiz

GPAT-Tutor

Placem ent s

PharmaS hine-2011

Co nferences

Fo rum

YOU ARE HERE

Pharma Analysis

SUBSCRIBE WITH US

TODAY'S POPULAR CONTENT

Pharma Analysis
Ads by Google

Enter your email address:

Vacancy as DRUG INSPECTOR in Government of India, APSPSC - 56 posts | Freshers may apply Opportunity in Pharmacopoeia Commission for Indian Medicine | Pharmacy Assistant, Research Officer, Scientific Officer, Director, Joint Director and More...Total 28 posts Career for Freshers in Novartis as Associate Scientist Formulation (Parental Topical) - M.Pharm freshers may apply Applications invited in Government of India for Drug Controller Officer 64 posts | Freshers may apply Women Scientists Scheme (WOS-C) on IPR, a scheme of Department of Science & Technology, Government of India more
QUICK LINKS

Job Pharma HPLC Analysis Soil Analysis Bulk Chemical

Pharmaceutical Analysis
INTRODUCTION
Pharmaceutical analysis is a branch of practical chemistry that involves a series of process for identification, determination, quantification and purification of a substance, separation of the components of a solution or mixture, or determination of structure of chemical compounds.

Do Not Forget to Verify (Click on Subscription link in your inbox)

The substance may be a single compound or a mixture of compounds and it may be in any of the dosage form. The substance used as pharmaceuticals are animals, plants, micro organisms, minerals and various synthetic products. The sample to be analysed is called as analyse and on the basis of size of sample, they can be classified as macro(0.1 g or more), semi micro (0.01 g to 0.1 g), micro(0.001 g to 0.01 g), sub micro (0.0001 g to 0.001 g), ultramicro (below 10-4 g), trace analysis(100 to 10000 ppm). Among all, the semi micro analysis is widely used.

Calcitriol www.cerbios.ch Cerbios-Pharma, Switzerland GMP manufacture ,US-DMF, CEP,... Chemical Crystallography www.rigaku.com Inexpensive benchtop XRD system to determine small molecule structure Chemical & Material Tests www.alliancetechgroup.com Comprehensive analytical laboratory for complex, non-routine testing Opus Disposable Columns www.repligen.com/bioprocessing Cost effective pre-packed columns for single-use bioprocessing

TYPES
There are main two types of chemical analysis. 1. Qualitative (identification) 2. Quantitative (estimation)
ACTIVE FORUM TOPICS

1. Qualitative analysis is performed to establish composition of natural/synthetic substances. These tests are performed to indicate whether the substance or compound is present in the sample or not. Various qualitative tests are detection of evolved gas, formation of precipitates, limit tests, colour change reactions, melting

NOTIFICATION MHT-CET-2012 | Government of

Course wise Alerts D.Pharm Alerts

1 of 4

1/19/2012 1:27 AM

Pharma Analysis | PharmaTutor

http://www.pharmatutor.org/pharma-analysis

point and boiling point test etc. 2. Quantitative analytical techniques are mainly used to quantify any compound or substance in the sample. These techniques are based in (a) the quantitative performance of suitable chemical reaction and either measuring the amount of reagent added to complete the reaction or measuring the amount of reaction product obtained, (b) the charatristic movement of a substance through a defined medium under controlled conditions, (c) electrical measurement, (d) measurement of some spectroscopic properties of the compound. Various types of Qualitative analysis: 1.Chemical methods a) volumetric or titrimetric methods b) gravimetric methods c) gasometric analysis 2.Electrical methods 3.Instrumental methods 4.Biological and microbiological

Maharastra mpharm pharmacology scope drug inspector. Natural products scope in canada Career in Regulatory affairs for Chemistry professionals more
JOBS BY SUBJECTS

B.Pharm Alerts B.Sc Alerts M.Pharm Alerts M.Sc Alerts MBA Alerts Pharm.D Alerts Ph.D Alerts

City wise Alerts Ahmedabad Alerts Baddi Alerts Bangalore Alerts Chandigarh Alerts Chennai Alerts Delhi Alerts Hyderabad Alerts Jaipur Alerts Kolkata Alerts Mumbai Alerts

Biology Biochemistry Biotechnology Chemistry Pharmaceutics

T ab le of content:

Pharmacognosy Pharmacology Microbiology

POPULAR ARTICLES

Absorption Spectroscopy (UV, Visible) IR Spectroscopy --1.Chemical methods a)Titrimetric or volumetric method It involves reaction of substance to be determined with an appropriate reagent as a standard solution, and volume of solution required to complete the reaction is determined. Volumetric methods require simple and less apparatus and they are susceptible of high accuracy. Various types of titrimetric methods are: i)Acid-base titrations (neutralization reactions) ii)Complexometric titrations iii)Precipitation titrations iv)Oxidation reduction titrations v)Non aqueous titrations b)Gravimetric methods In gravimetric analysis, a substance to be determined is converted into an insoluble precipitate in the purest form, which is then collected and weighed. It is the time consuming process. In electrogravimetry, electrolysis of the sample is carried out on the electrodes is weighed after drying. Thermogravimetry (TG) records the change in weight, differential thermal analysis (DTA) records the difference in temperature between test substance and an inert reference material, differential scanning calorimetry (DSC) records the energy needed to establish a zero temperature difference between a test substance and reference material.

Pune Alerts
BROWSE BY JOBS

A STUDY ON ANTIULCER ACTIVITY OF ACACIA LEAUCOPHLOEA BARK EXTRACT IN PYLORUS LIGATED RATS PHARMACEUTICAL PROCESS VALIDATION WHY TO DO, WHEN TO DO AND HOW TO DO IT A REVIEW REPORT ON: COATING OF SOFT GELATIN CAPSULES HUNTINGTONS DISEASE- No Panacea (Cure) yet! A REVIEW ON FAST DISSOLVING TABLET TECHNOLOGY User login
Username: *
Sunil Saikat

Production Jobs R&D Jobs F&D Jobs Sales & Marketing QA Jobs QC Jobs Faculty Jobs CRO Jobs DRA Jobs IPR Jobs IT Jobs Walk-in Jobs Government Jobs Hosptial Pharmacist
OUR FANS

PharmaTutor
on Facebook Like 8,648 people like PharmaTutor.

c)Gasometric analysis Gasometry involves measurement of the volume of gas evolved or absorbed in a chemical reaction. Some of the gases which are analysed by Gasometry are CO2 , N2O,cyclopropane, amyl nitrate, ethylene, N2, helium etc. 2.Electrical methods Electrical methods of analysis involve the measurement of electric current, voltage or resistance in relation to the concentration of some species in the solution.

Password: *

Log in Register | Forgot Password?

Facebook social plugin

2 of 4

1/19/2012 1:27 AM

Pharma Analysis | PharmaTutor

http://www.pharmatutor.org/pharma-analysis

Electrical methods of analysis include: (a)Potentiometry (b)Conductometry (c)Polarography (d)Voltametry (e)Amperometry Potentiometry measures electrical potential of an electrode in equilibrium with an ion to be determined. Conductometry measures electrical conductivity of an electrode with a reference electrode while Polarography, Voltametry and Amperometry measures electrical current at a micro-electrode. 3.Instrumental methods of analysis Instrumental method involves measurement of some physical properties of the compound or a substance. These methods are employed for determination of minor or trace concentration of element in the sample. Instrumental methods are preferred due to their selectivity, high speed, accuracy and simplicity of analysis. Any change in the properties of the system are detected by measurement of absorbance, specific rotation, refractive index, migration difference, charge to mass ratio etc. Spectroscopic methods of analysis depend upon measurement of the amount of radiant energy of a particular wavelength emitted by the sample. Methods which include absorption of radiation are ultra violet, visible, infra red, atomic absorption, nuclear magnetic resonance spectroscopy etc. Emission methods involve heating or electrical treatment of the sample so that the atoms are raised to the excited state to emit the energy and the intensity of this energy is measured. Emission methods include emission spectroscopy, flame photometry, flourimetry etc. Chromatographic techniques and electrophoretic methods are separation methods for the mixure of compounds, but also applied for identification of compounds of mixures. Various chromatographic techniques are GC, HPLC, TLC, HPTLC, PC etc. Mass spectrometry involves vaporization of material using a high vaccum and the vapour is bombarded by a high energy electron beam. Vapour molecules undergo fragmentation to produce ions of varying size. These ions are differentiated by accelerating them in electrical field and then deflecting them in a magnetic field. Each kind of ion gives a peak in the mass spectrum. 4.Biological and microbiological methods Biological methods are used when potency of a drug or its derivative can not be properly determined by any physical or chemical methods. They are called bio-assays. Microbiological methods are used to observe potency of antibiotic or anti- microbial agents. In antimicrobial assay, inhibition of growth of bacteria of the sample is compared with that of the standard antibiotic. These methods include cup plate method and turbidimetric analysis.

Orkut

FaceBook

APPLICATIONS
Manufacturing industries require both qualitative and quantitative analysis to ensure that their raw materials meet certain specifications, and to check the quality of final product. Raw materials are to be checked to ensure that the essential components are present within the predetermined range of composition and there are not any unusual substances present which might upset the manufacturing process or it may appear as a harmful impurity in the final product. In the development of new products which contains mixtures other then the pure material, it is necessary to ascertain composition of mixture which shows the optimum characteristics for which the material has been developed. Geographical surveys require analysis to determine the composition of soil sample and numerous rock samples collected from the field. Most of the industrial processes give rise to pollutants which may cause health

3 of 4

1/19/2012 1:27 AM

Pharma Analysis | PharmaTutor

http://www.pharmatutor.org/pharma-analysis

related problems. So quantitative analysis of air, water and soil sample should be carried out to determine the level of pollution and to establish the safe limits for pollutants.
Like 3 people like this. Be the first of your friends.

analytical testing www.criver.com GMP/GLP compliant analytical services for biopharmaceuticals

Cayman Pharma www.caymanpharma.com Your source for prostaglandin APIs and intermediates. Merck4Pharma:Formulation www.Merck-Chemicals.com/Formulation Your partner for the pharma formulations sector! Analytical Instruments www.conquerscientific.com GC, HPLC, LCMS, Microplate Readers Refurbished Laboratory Instruments

Ads by Google

API Chemical

API Pharma

Lab Analysis

Air Analysis

4090 reads

Tags Absorption spectrophometry

Pharma Analysis

Search PharmaTutor

Privacy Policy | Disclaimer | Sitemap | Advertise | Send Feedback | BioTecNika Copyright 2008-2012, PharmaTutor EduLabs

4 of 4

1/19/2012 1:27 AM