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  • Pa Tho Physiology of Acute Pyelonephritis

    Enviado por

    Crystal Diane Cardona
    332 visualizações2 páginas
    The document summarizes the pathophysiology of acute pyelonephritis. It involves the invasion of bacteria, usually E. coli, from the bladder into the kidneys up the ureters. This causes destruction of nephrons, injury to cells and inflammation in the kidneys. Symptoms include decreased urine output, increased ability to concentrate urine, pain, and increased blood flow and white blood cells at the infected site. Risk factors include instrumentation, urinary tract infections, renal stones, catheter insertion, poor hygiene, trauma from intercourse, and anatomical issues.

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    The document summarizes the pathophysiology of acute pyelonephritis. It involves the invasion of bacteria, usually E. coli, from the bladder into the kidneys up the ureters. This causes destruction of nephrons, injury to cells and inflammation in the kidneys. Symptoms include decreased urine output, increased ability to concentrate urine, pain, and increased blood flow and white blood cells at the infected site. Risk factors include instrumentation, urinary tract infections, renal stones, catheter insertion, poor hygiene, trauma from intercourse, and anatomical issues.

    Direitos autorais:

    Attribution Non-Commercial (BY-NC)
    Baixe no formato DOCX, PDF, TXT ou leia online no Scribd
    Sinalizar o conteúdo como inadequado
    332 visualizações2 páginas

    Pa Tho Physiology of Acute Pyelonephritis

    Enviado por

    Crystal Diane Cardona
    The document summarizes the pathophysiology of acute pyelonephritis. It involves the invasion of bacteria, usually E. coli, from the bladder into the kidneys up the ureters. This causes destruction of nephrons, injury to cells and inflammation in the kidneys. Symptoms include decreased urine output, increased ability to concentrate urine, pain, and increased blood flow and white blood cells at the infected site. Risk factors include instrumentation, urinary tract infections, renal stones, catheter insertion, poor hygiene, trauma from intercourse, and anatomical issues.

    Direitos autorais:

    Attribution Non-Commercial (BY-NC)
    Baixe no formato DOCX, PDF, TXT ou leia online no Scribd
    Sinalizar o conteúdo como inadequado
    de 2

    Invasion of CA to the surrounding tissues (renal papilla, medulla, cortex)

    Destruction of nephrons

    Injury to the cells and lining

    Passage of large molecules

    Decreased GFR

    Inflammation Release of chemicals (Kinins, Prostaglandins, Histamins)

    +2 CHON +1 Bilirubin +3 Urobilinogen +2 Leukotrase

    Decreased urine output

    Increased ability to concentrate urine (Specific gravity of 1.075)

    Chemotaxis

    Pain

    Increased blood flow to the injured site

    Increased WBC

    Increased neutrophils

    PATHOPHYSIOLOGY OF ACUTE PYELONEPHRITIS


    Instrumentation Hygiene Current UTI Sexually Active

    Gender

    Presence of Renal Stones

    Insertion of catheter & other birth contraception

    Poor personal Hygiene

    Urethral trauma upon intercourse

    Female

    Male

    Shorter urethra

    Prostatic Hypertrophy Calculi in the bladder Compression to the urethra

    Calculi in the nephrons

    Entrance of the CA (E.coli) Bacterial Infection of the bladder


    S/S: frequency; urgency, dysuria

    Colonization

    Obstruction

    Obstruction in urine flow

    Incompetence of vesiculoureter orifice

    Bladder dysfunction Urinary Stasis

    Increased pressure in the kidney


    S/S: flank pain

    Ascending of bacteria to the ureter and kidney

    Increased residual volume

    Colonization in the renal pelvis & parenchyma

    Hydronephrosis

    Bacterial Infection S/S: fever (38.7C), malaise, anorexia

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