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The “most emailed” New York Times article this past week has been Gina Kolata’s “Looking Past Blood
Sugar to Survive With Diabetes.” Given the high prevalence of diabetes that’s no surprise. But the article’s
thesis that a dogmatic fixation on controlling blood sugar may actually compromise other aspects of diabetes
care has no doubt piqued much interest.
There are many angles to this topic and diabetes in general – which affects so many people and intersects
with so many issues in medicine. Here’s a quick summary of the article and a consideration of some of the
additional questions it raises.
Summary
As Dr. David Nathan, director of the Diabetes Center at Massachusetts General Hospital said:
“… when you think about it, it’s not the diabetes that kills you, it’s the diabetes causing cardiovascular disease that
kills you.”
That quote alone probably sums up the main point of the article best.
Since insulin controls blood sugar and diabetes– at least in its simplified conception – involves a relative
lack of insulin, blood sugar (glucose) control has been the cornerstone of diabetes treatment for over a
half-century. However, the fixation (some would even say dogma) on stabilizing blood sugar can divert
attention from the fact that controlling cholesterol levels and blood pressure can be as important –
perhaps even more important – than rigorous blood glucose control. In fact, based on recent guidelines, a
cholesterol level of 110 which might otherwise have been cause for comfort for a non-diabetic may, in
fact, be considered to be too high for a diabetic patient and thus potentially warrant a statin drug regimen.
That’s not to say, of course, that high blood sugar is innocuous. As confirmed by numerous studies,
chronically elevated blood glucose levels can result in the classic diabetes complications of blindness
(diabetic retinopathy), nerve damage (diabetic neuropathy) and kidney damage (diabetic nephropathy).
However, studies (such as the DCCT and UKPDS trials) that have tried to link strict blood glucose
control with prevention of the disease’s cardiovascular complications have shown no such link or have
been equivocal at best.
Let’s put all this in stark, logical terms:
A. Cardiovascular disease caused by diabetes is what kills you (Dr. David Nathan)
B. Large-scale clinical trials have not shown a significant decrease in cardiovascular disease as a
result of strict blood sugar control
If statement “A” is true and statement “B” is true, then does it logically make sense that after dietary
measures strict blood sugar control is the primary goal in treating patients with Type 2 diabetes? That
logical inconsistency between what we know as fact and what is actually practiced is the underlying thesis
of the article “Looking Past Blood Sugar to Survive With Diabetes.” It’s a powerful argument and one
whose message needs to more widely disseminated.
Now for some additional questions and implications …
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(yet significant) cardiac effects that were seen later on, for example, with Vioxx and Avandia. This
approach, too, needs to be reformed. Indeed, given the special susceptibility of diabetes patients to
cardiovascular disease, then a more expansive and detailed pre-market approach to safety would have
involved Phase I clinical trials that even with the limited numbers of patients involved had used
innovative methods such as surrogate endpoints for cardiac effects to try to elicit these adverse effects
in a prospective manner among relatively small numbers of trial subjects.
The point is that if we know that cardiovascular disease kills patients with diabetes, then that sort of
information needs to be incorporated into the safety evaluation at the very earliest stages of drug
development. Just as the individual patients highlighted in Gina Kolata’s article who did not benefit from
this more expansive understanding of the disease, the population of patients who may have been harmed
by Avandia also suffer a collective tragedy from that information not being extensively used early on in the
drug development process.
The Rising Importance of Convergent (combination) Medical Technologies
Another theme of this blog has been the increasing importance of convergent medical technologies –
which are combinations of drugs and devices, devices and software, etc. The blog entry “Convergent
Medical Technology: Part I - What is it?” defines this new area intersecting among the biopharma, medical
device, nanotechnology and IT sectors. The concept of combination medical products involving
combinations of drugs is a subset of this wider trend towards technology convergence and combination.
Yet another interesting feature of the New York Times article (p.2) was that beyond blood sugar control, the
treatment of cardiovascular disease per se is critical to diabetes care, complex drug regimens including
statins (cholesterol lowering agents), antihypertensives in conjunction with the usual insulin or oral
hypoglycemic (anti-diabetic) drugs are becoming more commonplace. As the article writes:
Before he left the hospital, Mr. Smith’s doctors told him about his new diabetes regimen: a statin to drive his
cholesterol level very low, two drugs to lower his blood pressure, an aspirin, insulin and two drugs to reduce his blood
sugar levels. That new list of drugs was what he should have been taking all along.
…
“Right now, without waiting for lots of exciting things that are almost in the pipeline or in the pipeline, starting
tomorrow, if everyone did these things — taking a statin, taking a blood pressure medication, and maybe taking an
aspirin — you would reduce the heart attack rate by half.”
The article’s last section is entitled “The Burnout” which highlights how quite literally exhaustion and
complexity can lead patients to abandon the rigorous regimen required to fully manage their diabetes.
Physicians call this “noncompliance.” Patient noncompliance – for whatever the reasons involved – can
be fatal.
To this end then, a series of new combination drugs – also known as “polypills” that include several of the
required medications within one tablet can simplify compliance and minimize errors. Ultimately because
so much of this depends on patient and physician education, such a complex regimen when delivered
within a single combination form (or polypill) becomes simple. Combination drug therapies, taking
off-the-shelf drugs in new formulations, may not be glamorous and “cutting-edge” but they can truly play
a role in saving lives.
Is Diabetes a Surgical Disease?
A previous blog entry “The Diabetes Divide: Is Diabetes a Surgical or Medical Disease?” was titled
specifically to pique interest and perhaps generate a bit of controversy.
It is common knowledge that diabetes is a medical disease – namely that drug therapy, whether it be via
insulin or other medications, is the primary approach to therapy. Of course, there are surgical aspects to
diabetes. Amputations, for example, are a dreaded complication. The main point of that article was that a
reevaluation of the generalized (e.g. medication-based) approach to systemic blood sugar control may be in
order.
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The New York Times article also touches upon this – not the issue of surgery for diabetes per se but the
challenges involved in fully restoring the natural physiology of glucose control. As Gina Kolata writes:
“But no matter how carefully patients try to control their blood sugar, they can never get it perfect — no drugs can
substitute for the body’s normal sugar regulation.”
It is important to consider exactly what is meant by blood sugar control in the current practice of
diabetes. Blood sugar levels are typically sampled from the systemic venous circulation (basically the
infamous finger “prick” or, if in a doctor’s office or hospital, a full venous sample). Dosages of insulin
and/or oral hypoglycemics are then titrated to this systemic venous blood glucose level. As outlined in the
blog article, the actual anatomy of insulin regulation and secretion involves a localized distribution and
flow of insulin. Insulin is first secreted within the pancreatic portal circulation which then drains into the
hepatic portal (post-intestinal) circulation. This portal venous insulin exacts its effects first on the liver
and then on the systemic circulations. This implies (and this is significant) that blood insulin levels and
blood sugar levels are not evenly distributed throughout the body. This is what is ultimately meant by Gina
Kolata’s comment that “no drugs can substitute for the body’s normal sugar regulation.” There are other
subtleties to this such as the unique circulation within the pancreatic Islets of Langerhans and various
neuro-GI networks which also put into question the long-term effectiveness of blood glucose control via
systemic, generalized administration of insulin.
Indeed, when a process is unevenly distributed throughout the body – such as a broken leg – the approach
to the problem is not a generalized medical approach but rather a localized, surgical approach. It would
not be reasonable, for example, to imagine that a drug would “cure” a broken leg. Such a problem
requires setting the bone (“reducing the fracture” is the technical term) and casting at the site of injury.
Of course, drugs can be used to ameliorate pain or prevent infection (life-saving in their own regard) but
they do not fundamentally solve the problem.
To the extent that diabetes involves local pathology and local effects of glucose regulation, this is
inspiration for the idea that next-generation therapies for diabetes may ultimately involve more of surgical
approaches. Some may argue that there is no need for that. They would say that we definitely know that
the problem lies with a relative lack of insulin and that we have identified the culprit molecule – insulin -
and simply need to substitute for that the relative lack of that molecule. To that I would reply: why have
we not yet cured the disease?
I congratulate Gina Kolata on a great article on an important topic. A great article often raises more
questions than answers and I found that “Looking Past Blood Sugar to Survive With Diabetes?” has indeed
done that for me. Hopefully this blog article will also create more questions for you as well.
Avandia Diabetes blood sugar surgery FDA reform drug safety Gina Kolata convergent medical technologies combination medical products high
cholesterol hypertension David Nathan Massachusetts General Hospital Aesis Research Group Ogan Gurel
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