DRUG STUDY Name of drug Cefuroxime Dosage:IV 750mg q8 ANST (-) Classification: ANTIINFECTI VE; ANTIBIOTIC; SECONDGENERATION CEPHALOSPO

RIN.

MECHANISM OF INDICATION CONTRAINDICATION SIDE EFFECTS AND ACTION ADVERSE EFFECTS to Body as a Whole: Ceftin is a - Urinary tract Hypersensitivity cephalosporins and lactam type infection related antibiotics  Thrombophlebitis antibiotic. More (IV site); pain, specifically, it is a secondburning, cellulitis generation (IM site); cephalosporin. superinfections, Cephalosporins positive Coombs' work the same test. way as penicillins:  GI:Diarrhea, they interfere nausea, with the antibioticpeptidoglycan associated colitis, synthesis of the anorexia, bacterial wall by vomiting, inhibiting the final abdominal pain transpeptidation  Skin:Rash , needed for the pruritus, cross-links urticaria.  Urogenital: Increased serum creatinine and BUN, decreased creatinine clearance.  CNS: Headache, dizziness, lethargy,

NURSING RESPONSIBILITY
y

y y

Determine history of hypersensitivity reactions to cephalosporins, penicillins, and history of allergies, particularly to drugs, before therapy is initiated. Lab tests: Perform culture and sensitivity tests before initiation of therapy and periodically during therapy if indicated. Therapy may be instituted pending test results. Monitor periodically BUN and creatinine clearance. Inspect IM and IV injection sites frequently for signs of phlebitis. Report onset of loose stools or diarrhea. Although pseudomembranous colitis rarely occurs, this potentially lifethreatening complication should be ruled out as the cause of diarrhea during and after antibiotic therapy. Monitor for manifestations of hypersensitivity. Discontinue drug and report their appearance promptly. Monitor I&O rates and pattern: Especially important in severely ill patients receiving high doses. Report any significant changes.

paresthesia Generic Name: Ranitidine Brand name: Zantac Classification: Gastointestinal agent; Antisecretory (H2-receptor antagonist) Dosage: 50mg Frequency: Q8 Used to prevent ulcer Hypersensitivity or while patient is ranitidine component of on NPO formulation to any the  Instruct client to report any adverse reaction to the physician or nurse. Tell patient that antacids may decrease the absorption of ranitidine.  Inform patient that themedication may causedrowsiness, dizziness,or fatigue (use caution when driving or engaging in tasks requiring alertness).  Instruct patient toavoid taking any new medication during therapy without consulting prescriber.  Instruct patient to avoid alcohol and follow diet as prescriber recommends.

Competitive inhibition of histamine at H2receptors of the gastric parietal cells, which inhibits gastric acid secretion, gastric volume, and hydrogen ion concentration are reduced. Does not affect pepsin secretion, pentagastrinstimulated intrinsic factor secretion, or serum gastrin

Constipation Diarrhea Fatigue Headache Insomnia Muscle pain Nausea Vomiting Agitation Anemia Confusion

Depression Easy bruising or bleeding Hypersensitivity to Used for ketorolac, aspirin, other treating NSAIDs, or any inflammation component and pain in of the formulation; the operation patients who have developed site nasal polyps, angioedema, or bronchospastic reactions to other NSAIDs; active or history of peptic ulcer disease; recent or history of GI bleeding or perforation; patients with advanced renal disease or risk of renal failure; labor and delivery;

Generic Name: Ketorolac Brand name: Toradol Classification: Nonsteroidal AntiInflammatory Drugs (NSAIDs) Dosage: 30mg Frequency: Q6

Inhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase, which results in decreased formation of prostaglandin precursors, chemicals that cells of the immune system make that cause the redness, fever, and pain of inflammation and that also are believed to be important in the production of non-

Rash Ringing in the ears Headaches Dizziness Drowsiness Abdominal pain Nausea Diarrhea Constipation Heartburn Fluid retention

 Instruct client to report any adverse reaction to the physician or nurse. Tell patient that adverse reactions can occur with overuse.  Instruct client to avoid alcohol and maintain adequate hydration (2-3 L/day of fluids) unless instructed to restrict fluid intake.  Monitor for signs of pain relief, such as an increased appetite and activity  Instruct client to avoid taking ketorolac with aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), piroxicam (Feldene), etc

inflammatory pain.

nursing mothers; prophylaxis before major surgery; suspected or confirmed cerebrovascular bleeding; hemorrhagic diathesis; concurrent ASA or other NSAIDs; epidural or intrathecal administration; concomitant probenecid; pregnancy (3rd trimester