2010 USPC Official 5/1/11 - 7/31/11 Reference Tables: S...

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SOLUBILITIES Approximate Solubilities of USP and NF Articles Name and Volume, in mL, of Solvent Boiling Solute (1 g) Water Water Alcohol Chloroform Ether Other Acenocoumarol 67,000 280 130 1800 Acetaminophen 20 10 1 N sodium hydroxide, 15 Acetohexamide 230 210 Acetylcysteine 5 4 Acetyldigitoxin 6100 62.5 12 >10,000 Ammonium Alum 7 0.5 Aluminum Chloride 0.9 4 Aluminum Sulfate 1 Amantadine 2.5 5.1 18 polyethylene glycol Hydrochloride 400, 70 Amaranth 15 Aminocaproic Acid 3 methanol, 450 Aminohippuric Acid 45 50 3 N hydrochloric acid, 5 Aminosalicylate Sodium 2 Ammonium Carbonate 4 Amodiaquine 25 78 >10,000 >10,000 benzene, 10,000 Hydrochloride 1 2 Anethole Anileridine Anileridine Hydrochloride Antimony Potassium Tartrate Apomorphine Hydrochloride Apraclonidine Hydrochloride Ascorbic Acid Ascorbyl Palmitate Aspirin Atropine Atropine Sulfate Bendroflumethiazide Benoxinate Hydrochloride Benzalkonium Chloride (anhydrous) Gamma Benzene Hexachloride >10,000 5 12 50 34 3 50 74 >10,000 2 80 1 >10,000 >10,000 glycerin, 15 water at 80 , 20 methanol, 13; ethyl acetate, >10,000; hexanes, >10,000 >1000 10 to 15 25 water at 80 , 90 glycerin, 2.5 200 >10,000 100 3.5 40 benzene, 6 dehydrated alcohol, 20

3 >1000 300 460 0.5 0.8

2.5

40 125 5 2 5 23 2.6

>1000 17 1

2.5

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Benzethonium Chloride <1 Benzocaine 2500 Benzoic Acid Benzonatate Betadex Betamethasone Betamethasone Acetate Betamethasone Sodium Phosphate Betamethasone Valerate Bisacodyl Boric Acid Bromodiphenhydramine Hydrochloride Brompheniramine Maleate Busulfan Butabarbital Sodium Butamben Butylated Hydroxyanisole Butylated Hydroxytoluene Caffeine (hydrous) Calcium Chloride Calcium Gluconate 300 <1 54 5300 2000 2 10,000 >10,000 18 4 <1 5

<1 5 3 <1 65 9 470 16 210 18 2 15

<1 2 5 <1 325 16 >10,000 <10 2.5

6000 4 3 <1

almond oil or olive oil, 3050

warm alcohol, 15; methanol, 3

>10,000 400 275 boiling alcohol, 6; glycerin, 4 isopropyl alcohol, 31

2 15

3500

acetone, 45 2 7000 7 4.0 4.0 75 4 7000 2.0 1.1 6 10,000 1.2 1.1 600 boiling alcohol, 2

50 0.7 30 (slowly) Calcium Hydroxide 630 Calcium Lactate 20 Calcium Pantothenate 3 Calcium Sulfate 375 Camphor 800 Carbinoxamine Maleate <1 Carisoprodol 2083 Cephaloridine 5 Cetylpyridinium 4.5 Chloride Chloral Betaine 1

0.2 5 1300

485 1 1.5 2.5 1000 2.5 4 0.5 1.5 2.3 10,000 4.5 >10,000 1 8300 acetone, 2.5 10,000

Chloral Hydrate Chlorambucil Chloramphenicol

0.25 400

1.3

>10,000 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1 1.5 acetone, 2

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Chlordiazepoxide Chlorobutanol Chlorocresol Chloroprocaine Hydrochloride Chlorpheniramine Maleate Chlorpromazine Chlorpromazine Hydrochloride Chlortetracycline Hydrochloride Cholesterol Citric Acid Clindamycin Palmitate Hydrochloride Clindamycin Phosphate Clioquinol Cocaine

>10,000 125 260 20 4

50 1 0.4 100 10 3 1.5 560 100 (slowly) 2 3 >1000 3500 7 3.5 2 325 1300

6250

130 glycerin, 10

10 2 1.5 3 benzene, 2

1 75

dehydrated alcohol, 50 30 ethyl acetate, 9 >1000 120 1 15 0.5 >1000 4500 3.5

0.5

2.5 >100,000 600

olive oil, 12; liquid petrolatum, 80100

Cocaine Hydrochloride 0.5 Codeine 120 Codeine Phosphate 2.5 Codeine Sulfate Colchicine Cortisone Acetate Cupric Sulfate Cyanocobalamin Cyclizine Hydrochloride Cyproheptadine Hydrochloride Dehydrocholic Acid 30 25

50 boiling alcohol, 125; water at 80 , 0.5 water at 80 , 6.5 220

350 3 80 115 275 0.5 500 115 35 100

acetone, 75; dioxane, 30 glycerin, 3

75 26 35 2200 (15 )

methanol, 1.5 acetic acid at 15 , 135; acetone at 15 , 130; benzene at 15 , 960; ethyl acetate at 15 , 135 methanol, 40 methanol, 50

Demeclocycline Demeclocycline Hydrochloride Denatonium Benzoate Desipramine Hydrochloride Dexamethasone Sodium Phosphate Dexbrompheniramine Maleate

200 60 20 12 2 1.2 2.5 2 3000 2.4 14 2.9 3.5 5000 >10,000

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Dexchlorpheniramine Maleate Dextroamphetamine Sulfate Dextromethorphan Hydrobromide Dextrose Diazepam Dibucaine Dicyclomine Hydrochloride Diethylpropion Hydrochloride Digitoxin Dihydroergotamine Mesylate Dimercaprol Dimethisterone Diphenhydramine Hydrochloride Disulfiram Docusate Calcium Docusate Sodium Doxapram Hydrochloride Doxylamine Succinate Droperidol Dyclonine Hydrochloride Dydrogesterone Echothiophate Iodide

1.1 10 65 1 333 4600 13 0.5

2 800

1.7

2500

100 16 0.7 5 3 150 90

2 0.5 2 3 40 175

39 1.4 770

glacial acetic acid, 2

125 20 1 >5000 3300 70 (slowly) 50 1 10,000 60 >10,000 1

2600

3 2 30 >1

0.7 2 15 >1

acetone, 50

>1

2 140 24 40

2 4 2.3 2

370 500 >10,000 hexane, >10,000 200 dehydrated alcohol, 25; methanol, 3

Edrophonium Chloride 0.5 Enalaprilat 200 Ephedrine Ephedrine Hydrochloride Ephedrine Sulfate Epinephrine Bitartrate Ergotamine Tartrate Erythromycin Erythromycin Estolate Estradiol Estradiol Cypionate Estrone 20 3 1.3 3 500 1000

5 >1000 0.2 14 90 500 20 28 40 250 (15 ) 10 435 7 110 (15 )

dimethylformamide, 40; methanol, 68

acetone, 15 150 2800 boiling alcohol, 50; boiling chloroform,

>10,000

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Estropipate Ethacrynic Acid Ether Ethyl Vanillin Ferrous Gluconate Ferrous Sulfate Flumethasone Pivalate Fluocinolone Acetonide Fluorometholone Fluphenazine Enanthate Fluphenazine Hydrochloride Flurandrenolide Flurazepam Hydrochloride
1

>2000 12 100 (50 ) 5 1.5 0.5 >10,000 >1000 >10,000

>2000 1.6 2

>2000 6

>2000 3.5

80; acetone at 50 , 50; boiling acetone, 33; boiling benzene, 145 warm alcohol, 500

89 45 200 <1 6.7 72 4

350 25 2200 <1

2800 350 >10,000 2

1.4

10 90

5000

methanol, 25 methanol, 3; isopropanol, 69; benzene, 2500; petroleum ether, 5000 methanol, 14 glycerin, 15 methanol, 100; isopropyl alcohol, 33 water at 50 , 2.6; at 75 , 1.9; at 100 , 1.5

Fluroxene 220 Fructose Gentian Violet Glyceryl Monostearate Glycine Glycopyrrolate Guaifenesin Halazone Haloperidol Heparin Sodium Histamine Phosphate Homatropine Hydrobromide Hydralazine Hydrochloride Hydrocortisone Hydrocortisone Acetate Hydrocortisone Sodium Phosphate Hydroflumethiazide Hydromorphone Hydrochloride Hydroquinone 4 4.2 6070 >1000 >10,000 20 4 6 25

15 10 10.0 1254 30 140 60 260 >1000 15 35,000 >2000 200 100.0

40 500 40 230

420

acetone, 80 200

1.5 >5000 3 17 39 >5000 2500

51

16.5

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Hydroxocobalamin Hydroxyzine Hydrochloride Hydroxyzine Pamoate

50 1 >1000

100 4.5 700

10,000 13 >1000

10,000 >1000 >1000 dimethylformamide, 10; 10 N sodium hydroxide, 3.5

Hyoscyamine Hydrobromide Hyoscyamine Sulfate Ichthammol Indigotindisulfonate Sodium Indomethacin Iodine Ipodate Sodium

2.5 0.5 10 100 5

1.7

2300

3000 <1

50 13 2

30

40 carbon disulfide, 4; glycerin, 80 dimethylacetamide, 2; dimethylformamide, 3.5; dimethylsulfoxide, 3.5

Isoniazid Isopropamide Iodide Isopropyl Alcohol Isoproterenol Hydrochloride Isoproterenol Sulfate Isoxsuprine Hydrochloride

8 50 <1 3 4 500

50 10 <1 50 >2000 100

5 <1

<1

>2000 >10,000

Ketamine Hydrochloride Lactose

14

60

>2000 >10,000 0.1 N hydrochloric acid, 2500; 0.1 N sodium hydroxide, 100 >10,000 methanol, 6; absolute alcohol, 60

5 2.6 (slowly) Levorphanol Tartrate 50 Levothyroxine Sodium 700 Lisinopril 10 Magnesium Hydroxide >10,000 Magnesium Sulfate 0.8 0.5 Mannitol 5.5 Menadione Mesoridazine Besylate 1 Methacholine Chloride 1.2 Methacrylic Acid Copolymer

120 300 >10,000 >10,000 >10,000 >10,000

>10,000 methanol, 70 >10,000 glycerin, 1 (slowly) benzene, 10; vegetable oils, 50

60 11 1.7 3 2.1 6300

water in methanol ( 3 in 100), 10; water in alcohol ( 3 in 100), 10; water in isopropyl alcohol ( 3

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Methacycline Hydrochloride Methdilazine Hydrochloride Methenamine Methenamine Mandelate Methimazole Methocarbamol Methotrimeprazine Methoxyflurane Methsuximide Methyclothiazide Methylbenzethonium Chloride Methylene Blue Methylergonovine Maleate Methylparaben Methylprednisolone Methylprednisolone Acetate Methylprednisolone Sodium Succinate Methysergide Maleate Miconazole

100 2

300 2

>1000 6

1.5

12.5 10 5 10 <1 3 92.5 0.9 65 175 3 100 400

10 20 4.5 2 <1 <1 >10,000 >10,000

in 100), 10; water in acetone ( 3 in 100), 10 >1000 0.1 N sodium hydroxide, 25 >10,000 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1 320 350 125 methanol, 10 <1 2 2700 0.7

5 40 (20 ) 10 500 350 >10,000 0.8 25 100 400 10,000 1500

1900

8400 10 800 1500 water at 80 , 50

800 250

1.5 200 >100,000

12 165 9.5

>10,000 3400 2

Miconazole Nitrate

6250

312

525

Morphine Sulfate Nalidixic Acid Neomycin Sulfate Niacin Niacinamide Nifedipine Nitrofurazone

16 >1000 1 60 1.5 10 >10,000 4200

570 910 29

>10,000 >10,000 15 isopropyl alcohol, 4; propylene glycol, 9; methanol, 5.3 50,000 isopropyl alcohol, 1408; propylene glycol, 119; methanol, 75 alcohol at 60 , 240; water at 80 , 1 >1000

5.5 590 >2000 300 10 >2000 >2000 acetone, 10 propylene glycol, 350

Nitromersol >2000 Norepinephrine 2.5 Bitartrate Norethindrone Acetate >10,000

<1

18

dioxane, 2

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Nortriptyline Hydrochloride Oxandrolone Oxazepam Oxtriphylline Oxymetazoline Hydrochloride Oxymetholone Oxymorphone Hydrochloride Oxytetracycline Oxytetracycline Calcium Papaverine Hydrochloride Paraldehyde Paramethasone Acetate Paromomycin Sulfate Pectin Penicillin G Benzathine Sterile Penicillin G Procaine Sterile Penicillin G Sodium Penicillin V Benzathine Penicillin V Potassium Pentazocine Pentazocine Hydrochloride Pentobarbital Pentolinium Tartrate Perphenazine Phenazopyridine Hydrochloride Phenindamine Tartrate Phenmetrazine Hydrochloride Phenobarbital Phenol Phentolamine Mesylate Phenylethyl Alcohol
1

90 5200 >10,000 1 6.7 >10,000 4 4150 >1000 30 10 17

30 57 220 3.6 40 100

20 <5 270 862 5 >1000 >10,000 >1000 82 >1000 6250 >1000 860 2200

methanol, 10 acetone, 69

dioxane, 14 methanol, 25 absolute alcohol, 66 0.1 N sodium hydroxide, 15

>1000 120

50 <1 20 5000 250 40 3200 >1000 30 >2000 0.5 <10 40 0.4 1000 15 1 60 20 330 150 11 20 4.5 475 7 59 350 2 10 42 2 4 4.0 >1000 331 910 42 >10,000 10 >2000 >5000 >10,000 >10,000 65 30 >10,000

methanol, 40

60

acetone, 37

acetone, 13 cold water, 300; glycerin, 100

mineral oil, 70 4 <1 700 <1 <1 alcohol solution (1 in 2), 2; diethylphthalate, <1; benzyl benzoate, <1

Phenylmercuric Acetate 180 Phenylmercuric Nitrate 600 Phenylpropanolamine 1.1

225 7.4

6.8 4100

200

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Hydrochloride Physostigmine Salicylate Physostigmine Sulfate Pilocarpine Hydrochloride Pilocarpine Nitrate Piminodine Esylate Pimozide

75 4 0.3 4 >1000 >10,000

16 0.4 3 75 6 1000

250 1200

360

2 10

>1000 1000

Polyethylene Glycol 1540 Polyethylene Glycol 4000 Potash, Sulfurated Potassium Acetate Potassium Alum Potassium Benzoate Potassium Chloride Potassium Citrate Potassium Gluconate Potassium Hydroxide Potassium Iodide Potassium Permanganate Potassium Sodium Tartrate Potassium Sorbate Pramoxine Hydrochloride Prednisolone Prednisolone Acetate Prednisolone Hemisuccinate Prednisolone Sodium Phosphate Prednisone Prilocaine Hydrochloride Primaquine Phosphate Primidone Procaine Hydrochloride Prochlorperazine Edisylate

1 4 2 0.5 7 2 2.8 1 3 1 0.7 15 1 4.5 35 2.5

3 2

acetone, 100; methanol, 1000; 0.1 N hydrochloride acid, >1000 absolute alcohol, 100

0.2 0.3

3 75 alcohol solution (9 in 10), 50 glycerin, 2.5 3 22 glycerin, 2.5 glycerin, 2

0.5 3.5

>1000 35 180 1064

>1000

4170 4

30 120 6.3

acetone, 50 248 methanol, 13

3.5 15 2000 1 2

150 4.2

200 175

200 15 1500

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Prochlorperazine Maleate Procyclidine Hydrochloride Promazine Hydrochloride Propoxycaine Hydrochloride Propoxyphene Napsylate Propylhexedrine Propylparaben Protriptyline Hydrochloride Pseudoephedrine Hydrochloride Pyrazinamide Pyridoxine Hydrochloride Pyrilamine Maleate Pyrimethamine Pyrrocaine Hydrochloride Quinidine Sulfate Quinine Sulfate Reserpine Resorcinol Rotoxamine Tartrate Saccharin Saccharin Calcium Saccharin Sodium Salicylic Acid Scopolamine Hydrobromide Secobarbital Selenium Sulfide Sennosides Silver Nitrate Simethicone
2

1200 35 3 2 10,000 >500 2500 2 0.5 67 5 0.5 1.5 100 500 1 10 290 2.6 1.5 460 1.5 115 3 200 12 10 120 1800 1 100 31 4.7 50 3 20 2 125 8 15 6 >10,000 >10,000 absolute alcohol, 15 10 15 0.4 1.5 3.5 3.6 >10,000 10 0.2 2.5 91 135 0.1 3 >10,000 7000 1000 absolute alcohol, 175; methanol, 72 80 9 6 11,000

400

25

15

45

benzene, 135

0.5 N sodium hydroxide, 8.5 35 0.4 0.1 >10,000 2100 30 161 3700 10
2

1667 6100 boiling alcohol, 6.5 10

2

benzene, 10 ; absolute alcohol, >10,000

Sodium Acetate Sodium Ascorbate Sodium Benzoate Sodium Bicarbonate

0.8 1.3 2 12

0.6

19 75 90 percent alcohol, 50

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Sodium Bisulfite Sodium Borate Sodium Carbonate Sodium Chloride Sodium Citrate (hydrous) Sodium Fluoride Sodium Formaldehyde Sulfoxylate Sodium Hydroxide Sodium Iodide Sodium Lauryl Sulfate Sodium Nitrite Sodium Phosphate, Dried Sodium Propionate Sodium Thiosulfate Sorbic Acid

4 16 3 2.8 1.5 25 3.4 1 0.6 10 1.5 8 1 0.5 1000

1 1.8 2.7 0.6

glycerin, 1 glycerin, 10

510

175

180

glycerin, 1

0.65

24 10

>10,000 15

>10,000 30 absolute alcohol, 8; methanol, 8; propylene glycol, 19

Sorbitol Stanozolol Stearic Acid Stibophen Succinylcholine Chloride Sucrose Sucrose Octaacetate

0.45 >1000 1 1 0.5 1100 0.2

41 74 20 2 >10,000 >10,000 350 170 11

370 3 10,000

Sulconazole Nitrate

3333

100

333

acetone, 0.3; benzene, 0.6; toluene, 0.5 pyridine, 10; methanol, 71; acetone, 130; methylene chloride, 286; toluene, 2000; dioxane, 2000 human serum at 37 , 620

Sulfacetamide Sodium 2.5 Sulfadiazine 13,000 Sulfadiazine Sodium Sulfadimethoxine Sulfaethidole 2 200 >3000 75 1300 1700

Sulfamethizole Sulfamethoxazole

2000 3400

38 50

1900 1000

1900 1000

2 N hydrochloric acid, 50 methanol, 51; acetone, 13; benzene, 2277 acetone, 13 carbon disulfide, 2 (slowly and usually incompletely)

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Sulfapyridine Sulfasalazine Sulfisoxazole Sulfisoxazole Acetyl Precipitated Sulfur

3500 >10,000 7700

440 2900 176

>10,000 35

Tartaric Acid Terpin Hydrate Testolactone Testosterone Tetracaine Tetracycline Tetracycline Hydrochloride Tetrahydrozoline Hydrochloride Theophylline Sodium Glycinate Thiamine Hydrochloride Thiamine Mononitrate Thiethylperazine Maleate Thimerosal Thioguanine Thiotepa Thiothixene Thiothixene Hydrochloride Thymol Tolazoline Hydrochloride Triamcinolone Diacetate Triamterene Triazolam Trichlormethiazide

0.8 200 4050 >1000 2500 10 3.5 6 1 44 1700 1 13 >10,000 8 1000 <1

0.5 35

3 13

140 2 2

acetone, 65 >10,000 methanol, 1500 boiling alcohol, 10 1064 methanol, 203 carbon disulfide, 2 (slowly and usually incompletely); olive oil, 100 250 methanol, 1.7 140 boiling alcohol, 3 100 2 absolute alcohol, 6

5 50 100 7.5

>1000

>1000

170 530 12 7700 8.3 >10,000 >10,000

1.9 2 280

4.1 120

1 2 13

1 3 80

absolute alcohol, 110 >10,000 absolute alcohol, 270 1.5 olive oil, 2 >10,000 methanol, 40 formic acid, 30; 2methoxyethanol, 85 >10,000 0.1 N hydrochloric acid, 600 1400 dioxane, 9.1; dimethylformamide, 4.35 methanol, 8; acetone, 9.5; benzene, 18

>10,000 1100

1000 48

25 5000

Trichloroethylene Triethylenemelamine

>10,000 2.5

13

3.6

Trifluoperazine Hydrochloride

3.5

11

100

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Triflupromazine Hydrochloride Trimeprazine Tartrate Trimethobenzamide Hydrochloride Trioxsalen

<1 2 2

<1 20 59 1150

1.7 5 67 84 1800 720 methylenedichloride, 43; 4-methyl-2pentanone, 100 acetone, 350 2000

Tripelennamine Hydrochloride Triprolidine Hydrochloride Tromethamine Tubocurarine Chloride Urea Vanillin Xylometazoline Hydrochloride Zinc Acetate Zinc Chloride Zinc Sulfate 1

1 2.1 1.8 20 1.5 100 35 2.5 0.5 0.6

6 1.8 45.5 45 10

6 1 >10,000

boiling alcohol, 1 glycerin, 20; water at 80 , 20

30 1.5

glycerin, 2 glycerin, 2.5

Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents.

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