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J Nephrol. 2004 Jan- Feb;17(1):166- 71.

Homer Smith: 'master of all things renal'. [Hosp Pract (Off Ed). 1982] Homer Smith: his contribution to the practice of nephrology. Nephrol. 1995] [J Am Soc Homer Smith: his contribution to physiology. [J Am Soc Nephrol. 1995] Review Changing concepts of compensatory renal growth: from 1992] [Am J Nephrol. Review [History of nephrology in the past 100 years: Significance of [Nihon Naika Gakkai Zasshi. 2002]
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The development of the clearance concept.


Seldin DW.
Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75390- 9030, USA. ann.welch@utsouthwestern.edu

Abstract
The clearance concept is central to three critical areas of nephrology; it was a key feature to early conceptual analysis of the nature of urine formation, it was utiliz ed as a measure of kidney function in advancing renal diseases, and it was a pivotal concept to elucidate the physiology of the kidneys. This paper describes the clearance concept as currently understood and then it examines how clearance was utiliz ed to understand these various aspects of kidney function.
PMID: 15151274 [PubMed - indexed for MEDLINE]

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