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NATURAL THERAPY 1 Can Eating Apple Pie Lower Your Blood Sugar? ..................................... 1 NATURAL THERAPY 2 A Nutrient Powerhouse and Metabolism Booster ................................... 5 NATURAL THERAPY 3 How a Stinking Rose Can Prevent a Heart Attack or Stroke ................. 10 NATURAL THERAPY 4 The Japanese Secret to Weight Loss and Longevity ............................. 14 NATURAL THERAPY 5 Superfood or Toxic Killer? ................................................................... 20
WARNING: To be clear, none of these superfoods should be viewed as a cure-all or magic bullet such a thing simply does not exist.
The single most important action you can take is to change your ENTIRE diet to be one full of nutrient-dense, whole foods, followed by engaging in daily exercise. Yes, I am sure youve heard that before and thats because its truetheres simply no avoiding that fact. The food you eat and the exercise you engage in will be the predominant determinants as to whether you lead a vibrant, energetic life or one plagued by one health problem after another. But, we have to be realistic we are living in a world full of toxic foods and surrounded by lifestyle choices that inevitably lead us to becoming a sick, overweight couch potato. To that end, we could all use a helping hand and thats just what Mother Nature has provided us in these superfoods. From the entire team here at Natural Health Sherpa, we truly hope you enjoy this report. And if its something that you like, please feel free to share it using the Twitter and Facebook links youll find at the end. Naturally yours, The Natural Health Sherpa Team
N AT U R A L THERAPY 1
The idea of using this special ingredient medicinally is far from new. Chinese, Ayurvedic and naturopathic medicine all utilize it for a variety of conditions, including nausea, bloating, GI upset, and libido enhancement. However, it was the accidental discovery of its benefits for treating and preventing type 2 diabetes that has made this special ingredient one of the worlds most celebrated spices. You may be surprised to learn that this special ingredient is something that youve likely used dozens, if not hundreds of times before: cinnamon.
s it possible that eating apple pie can actually lower your blood sugar? The answer is yes, but ONLY if it contains this one critical ingredient.
Now, let the dog out, turn off the television, and settle the kids down with a snack and a game and your spouse will finally be able to hear you! Thats how insulin resistance/insulin responsiveness works. If there is too much insulin or noise in your bloodstream, your cells cannot hear the message. But if you turn down the noise (i.e. improve glucose metabolism), your cells can hear the message and allow the insulin receptors to be more responsive. Of course, we cant promise the same results with your spouse! And, when cells are better able to hear insulins message; and can better absorb and use glucose, the result is lower blood glucose levels. Type 2 diabetes is caused by your body becoming resistant to the effects of insulin. The bottom line here is that cinnamon appears to help reduce this resistance. Though this sounds great in theory, lets see if the studies support the hypothesis.
Once again, less than a teaspoon of cinnamon seems to reduce blood sugar levels. Thats about the amount you would sprinkle on your oatmeal in the morning. Not a bad way to start the day. Finally, researchers2 also tested the use of cinnamon versus insulin to encourage glucose metabolism. Using an in vitro (think test tube) cell culture, researchers found that the bioactive polymer in cinnamon stimulated glucose uptake and glycogen synthesis to a level comparable to that achieved by insulin. In other words, the tasty spice worked as well as the medicationat least in a laboratory. It would be interesting to see this repeated in humans to determine if cinnamon would still perform as well as insulin in type 2 diabetics.
Finally, replicate Dr. Andersons apple pie experimentsort of. Core an apple, then it cut in half from top to bottom. Sprinkle with cinnamon and bake at 375F for 20 minutes or until the apple is soft. No matter how you use cinnamon, if you are either at risk for or have been diagnosed with type 2 diabetes, it is one spice you should get to know. Just remember that cinnamon should be a tasty addition to your diabetes programnot the starring role. The most powerful method for reversing your type 2 diabetes requires substantial changes to your lifestyle including eating a diet chock full of nutrient-dense, low glycemic-load whole foods and to engage in moderate daily exercise. And as always, check with your doctor when adding any herb, spice, or supplement to your medical regimen.
References:
MacKenzie, Debora. Cinnamon spice produces healthier blood. New Scientist. November 24, 2003.
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Jarvill-Taylor, KJ, et al. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr. 2001 Aug; 20(4): 327-36.
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McBride, Judy. Cinnamon Extracts Boost Insulin Sensitivity. Agricultural Research Magazine. 2000 July; 48(7): 21.
Khan, MS, et al. Cinnamon Improves Glucose and Lipids of People With Type 2 Diabetes. Diabetes Care 26 (2003): 3215-18.
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Mang, et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006 May; 36(5): 340-4.
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Cinnamon
N AT U R A L THERAPY 2
Suddenly it becomes obvious which of your fellow sand dwellers are tourists and which are locals. Not only do the locals have a glow about their skin and trim figures, but they also seem to be oozing with abundant health and energy to spare! Plus, there isnt a sniffle, cough, runny nose or apparent headache in sight. What on earth can their secret be? Is it the sun? The stress-free life? The salt air? Those things may play a role, but the real secret lies within the worlds largest seed.
magine you are walking the beach on the North Shore of Oahu in Hawaii. All around you, people are surfing, hiking, jogging, swimming and paddleboarding.
been raised using conventional feedlots and fed an unnatural diet of corn and soy, the fat in coconut oil is actually a medium-chain triglyceride. These fats are more easily digested than other fats and are quickly metabolized, giving you a great source of energy. Also, your body uses medium-chain triglycerides differently than other fats. Most fats are stored in your bodys cells. But the fat in coconut oil goes directly to your liver, where it is converted into energy. In laymans terms, that bacon and cheese omelet you ate most likely sits around in your cells waiting to be burned up or stored as fat for later. However, coconut oil gets shipped directly to your liver, where it is put to work to help you get up and get going.
Coconut Oil
When it comes to antibacterial properties, one study in particular found that virgin coconut oil helped to treat skin infections.3 Researchers performed a double-blind, placebo-controlled study of 26 people who had atopic dermatitis, a skin condition that often includes painfully dry skin that is highly susceptible to a nasty bacterium called Staphylococcus aureus. Researchers had half the group use virgin coconut oil twice a day for four weeks at two noninfected sites. The other group used virgin olive oil, also applying it twice a day for four weeks. When the study started, 20 of the 26 participants tested positive for Staphylococcus aureus. At the end of the study period, only one of the virgin coconut oil users (5 percent) tested positive for the bacteria, as compared to six users (50 percent) in the olive oil group. The coconut oil also relieved the users dry skin. Researchers concluded that coconut oil might be useful for treating bacteria, fungi, and viruses. While we agree, wed like to see this type of gold standard study repeated with a larger participant pool, as well as with a variety of bacteria strain, just to be sure.
fatten up their livestock, so they gave them coconut oil. However, the animals became leaner and more active. This is quite intriguing, but cannot be attributed to any credible source, but we did discover a human study that seems to back this up. In a study of people in the Yucatan Peninsula of Mexico, where coconut is a staple food, researchers found that their metabolic rate was an average of 25 percent higher than people in the U.S. However, like the farmers/livestock example, we cannot substantiate this commonly cited study either. Both appear to be perpetuated by the same author, who never cites the studies he is pulling from. Though the mechanism of action of medium-chain triglycerides and fat-burning makes sense physiologically, we were ready to dismiss the connection between coconut oil and weight loss due to a lack of clinical evidence. Then we came across several studies which included a randomized, placebo-controlled, double-blind study from Brazil5. Researchers tested the effects of coconut oil on 40 women between the ages of 20 to 40, with clinical abdominal obesity (waist circumference of more than 88 cm). Half of the group received a daily dose of either soybean oil or coconut oil for 12 weeks. Both of the groups were instructed to follow a balanced, low-calorie diet and to walk for 50 minutes each day. At the end of the study period, those taking the coconut oil had a statistically greater loss of waist circumference that those taking the soybean oil. The coconut oil users also had a statistically higher level of HDL (good) cholesterol and a lower LDL/HDL ratio than the soybean oil group. Both groups enjoyed a decrease in their body mass index (BMI). So, those using the coconut oil lost weight, lost inches around their waist, increased their levels of good cholesterol, and improved their bad to good cholesterol ratio. Not bad for a big seed!
unrefined, unbleached, made without heat processing or chemicals, and is non-GMO. We are sure that after a few days with this outstanding oil, youll be loco for coconut, too!
References:
Intahphuak, S, et al. Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil. Pharm Biol. 2010 Feb. 48(2):151-7.
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Ogbolu, DO, et al. In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria. J Med Food. 2007 Jun. 10(2)384-7.
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Verall-Rowell, VM, et al. Novel actibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis. Dermatitis. 2008 Nov-Dec.19(6):308-15.
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Prior IA, et al. Cholesterol, coconuts and diet in Polynesian atollsa natural experiment; the Pukapuka and Toklau island studies. Am J Clin Nutr 1981. 34:1552-61.
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Assuncao, ML, et al. Effects of dietary coconut oil on the biochemical and antrhopometric profiles of women presenting abdominal obesity. Lipids. 2009 Jul. 44(7):593-601.
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Coconut Oil
N AT U R A L THERAPY 3
ach day, thousands of people gleefully walk out of their cardiologists office with a prescription in hand. But, they are later shocked to discover that these are actually prescriptions for disaster. You see, these prescriptions are most often for a statin drug to lower cholesterol or some type of blood thinner to help prevent stroke or other related blood-clotting health concern. But how often do they tell you the myriad of horrendous side effects associated with these drugs, or how they rob your body of vital nutrients? Or, worse yet, do they tell you that the condition they are treating you for (especially high cholesterol) isnt even the REAL issue? For years, the medical community has known that inflammation is the real culprit in heart disease. However, they keep shelling out prescription after prescription to lower bad, evil cholesterol, all the while letting inflammation run rampant. As if it couldnt get any worse, they never tell you that there is a natural option to both treating cholesterol and preventing blood clots and stroke. And they definitely wont tell you that you can cook with this miracle substance or simply take it in supplement form. What they may know (or maybe not!) and arent telling you is that this heart-saver is probably sitting in your kitchen cupboard right now. Its garlicyep, garlic.
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draw some broad conclusions as to it efficacy. They combed 11 electronic databases, references, etc. dated from January 1966 through February 2000 and limited their research to randomized, placebo-controlled studies that were at least four weeks in duration. They found that, as compared with a placebo, garlic helps to reduce total cholesterol, LDL cholesterol, and triglyceride levels when taken for one month or three months, but not at six months. They also found that garlic helped to significantly reduce platelet aggregation. Once again, garlic is shown to help lower cholesterol and reduce your risk for blood clots by reducing platelet aggregation. Okay, we get it. Garlic works.
You can add it to your main course, along with onions and peppers, or saut it with your favorite vegetables. You can even roast it with olive oil and use in place of butter as a spread. But if you opt to use garlic supplements, aim for at least 7.2 grams of aged garlic extract. Be sure to choose a product that is free of preservatives, fillers, binders, excipients, flow agents, shellacs, coloring agents, gluten, yeast, lactose, and other allergens. Ideally youll also be able to find independent analysis done by a third party to verify the active ingredients and identify any contaminants. In addition to the famous odor (thanks allicin!), garlic does have a few other side effects. Some people are allergic to garlic, while others may experience some stomach or intestinal upset, flatulence, or possible bleeding. Also, because garlic helps to thin the blood, you should check with your doctor before using garlic if you are taking a prescription blood thinner. Still, if you (and those around you) can handle the occasional bad breath or body odor caused by garlic, it seems to be an all-around heart protector. So, go ahead and embrace that stinking rose. Your body will thank you. And remember, there is no magic bullet solution to improving your health. The most effective action you can take is to make permanent changes to your lifestyle to include a diet of nutrient-dense, low glycemic-load whole foods.
References:
Lau, BH. Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefits. J Nutr. 206 Mar. 136 (3 Suppl):765S-768S.
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Steiner, M and Lin, RS. Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract. J Cardiovasc Pharmacol. 1998 Jun. 31(6):904-8.
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Steiner, M and Li, W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr. 2001 Mar. 131(3s):980S-4S.
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Ackermann, RT et al. Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med. 2001 Mar 26.161(6):813-24.
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1971.
6Yu, TH and Wu, CM. Stability of allicin in garlic juice. J Food Sci. 1989. 54(4):977-81. Lawson, LD and Hughes, BG. Characterization of the formation of allicin and other thiosulfinates from garlic. Planta Med. 1992. 58:345-50.
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Freeman, F and Kodera, Y. Garlic chemistry: stability of s-(2-propenyl)-2-propene-1sulfinothioate (allicin) in blood, solvents, and simulated physiological fluids. J Agric Food Chem. 1995. 43:2332-8.
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N AT U R A L THERAPY 4
Okay, now, what is the one thing that can help reduce your risk for all three? A few hints: its natural, you drink it and its a subset of the second-most consumed beverage in the world after water. If you said green tea, you are right. Youve probably heard of green tea before, but once youre done reading this, youll never think about green tea the same way again. And you will likely start drinking it every day to capture some of its remarkable health benefits including its ability to help you lose weight and battle cancer, heart disease and strokes.
uickwhat are the three biggest health conditions plaguing Americans today? If you said cancer, heart disease, and obesity, you would likely be right.
you? The major polyphenols are primarily flavonoids and include: catechins, which are also found in cacao beans (yep, chocolate!) proanthocyanidins, which were once referred to as vitamins and are also found in apples, cinnamon, grape seed, and red wine epigallocatechin gallate, which is abbreviated and commonly referred to as EGCG Of these, EGCG is the most widely associated with green tea, and is in fact the nutrient that supposedly gives this common beverage its health advantages. Specifically, proponents of green tea claim it can prevent Americas most feared health conditions: cancer, heart disease, and obesity. But are these advantages real or just medical lore? Lets head to the studies to find out.
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It would be nice to see a few double-blind, randomized, placebo-controlled studies (the gold standard in research) on actual humansnot just cells or recaps of other studies. However, given the serious nature of cancer, this may not be feasible. And, just as there are many studies on green teas benefits on a wide variety of cancers, there are also many theories on how green tea helps fight cancer. The key hypotheses include: The polyphenols appear to enhance the activity of the bodys antioxidant and detoxifying enzymes. Polyphenols prevent the formation of cancer-causing compounds, such as nitrosamines (compounds formed when the nitrites in cured foods bind with amino acids). Polyphenols block carcinogen activity by binding to tissue receptor sites. This would be particularly effective in breast cancer prevention. As polyphenols bind to receptor sites on breast tissue, they prevent carcinogens from binding to and harming the cells. In essence, the polyphenols seal off the tissue from invasion by carcinogens. Regardless of how it may work, or how effective it may actually be, the studies and logic behind the mechanism of action is promising enough that sipping a cup or two of hot green tea a day certainly wont hurt and may actually help prevent some forms of cancer.
Green Tea
drinking, non-smoking women age 40 and older found that those who drank five or more cups of green tea per day enjoyed a 50 percent reduction in strokes.8 Again, the studies appear to be promising, but they lack the gold standard double-blind, placebo-controlled protocol we prefer.
Sencha comes from green tea whose leaves are exposed to direct sunlight. It is the most common type of green tea in Japan. Matcha is a fine, almost powdered, green tea made from Tencha tea, which is grown in the shade and has a slightly sweet smell. Matcha is the primary tea used in tea ceremonies. To reap all of the benefits of green tea, youll want to aim for 3-5 8 oz. cups of green tea each day. And to help you get the most out of your tea experience, try these tips: For maximum potency, store your green tea leaves or bags in a lightproof, airproof container. And brew a fresh cup every time, allowing the tea to steep for 3-4 minutes. Try drinking your green tea straight up, just to see how naturally delightful it is. If you prefer a bit of sweetener, try a little honey. Tuck a small tin of green tea bags into your purse or briefcase so youll always have it handy. If youre eating on the run, look for unsweetened, bottled green tea (such as Ito En). You can even pick up an unsweetened iced green tea at your local Starbucks. If you prefer not to drink the tea, any of these options provides the same level of protection. You can also opt for 300 to 400 mg daily of green tea extract. Be sure the product is standardized to 80 percent total polyphenol and 55 percent epigallocatechin. No matter how you pour it, green tea is a cup with clout. With its healthful properties and sensory delights, its the one beverage thats truly worthy of the toast, To your health!
References:
Yang, CS and Wang, ZY. Tea and cancer. J Natl Cancer Inst. 1993 July 7;85(13):103849.
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Gao, Y et al. Reduced risk of esophageal cancer associated with green tea consumption. J Natl Cancer Inst. 1994 June 1;86(11):855-8.
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Sun, CL, et al. Green tea, black tea as well as breast cancer risk: a meta-analysis of epidemiological studies. Carcinogenesis. 2006;27(7):1310-15.
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Maryam, R et al. Green Tea Inhibits Vascular Endothelial Growth Factor (VEGF) Induction in Human Breast Cancer Cells. J Nutr. 2002;132:2307-11.
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Wu , AH, et al. Green tea as well as risk of breast cancer in Asian Americans. Int J Cancer. 2003 Sept. 10;106(4):574-9.
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Kuriyama, S et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan. JAMA. 2006 Sept 13; 296:1255-65.
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Kono, S et al. Green tea consumption and serum lipid profiles: A cross-sectional study in Northern Kyushu, Japan. Preventive Medicine. 1992 July;21(4)526-31.
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Sato, Y. et al. Possible contribution of green tea drinking habits to the prevention of stroke. Tohoku J Exp Med. 1989 April;157(4):337-343.
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Green Tea
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Dulloo, AG, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999;70(6):1040-5.
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Phung, OJ et al. Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. Am J Clin Nutr. 2010 Jan;91(1):7381.
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N AT U R A L THERAPY 5
In one corner are those who proudly profess the almost miracle-like qualities of this food, with boastful claims about how it can do everything from curing cancer to preventing heart disease and even menopause. In the other corner there is a persnickety bunch who retorts that this food is anything but a miracle. They claim it can lead to thyroid disease, actually CAUSE cancer, hamper your immune system, destroy your brain, make you infertile, and even turn males into females! So what is this food thats prompting two equally passionate groups to go to war? Its soyand each side in this battle is going out of its way to convince you that soy is either the messiah of health or the devil itself. So whos right, how will this affect you and your childrens health and what should you do?
here is an epic battle being waged over a common food that you and your children likely are exposed to every single day.
After reviewing 38 placebo-controlled clinical trials, researchers concluded that individuals who consumed an average of 47 grams of soy protein per day had a 13 percent decrease in LDL cholesterol, a 10.5 percent decrease in triglycerides, and a 9 percent decrease in total cholesterol levels. While this is clearly strong support in favor of soys ability to lower cholesterol levels, what it doesnt lay out is the form of soy protein. Was it a powder, the actual soybean itself, tofu (soybean curd), or tempeh (fermented soy)? Or was it a textured, processed soy food? As odd as it may sound, the form of soy really does matteras youll soon see. In another study2, researchers gave 42 participants with high LDL cholesterol levels four different diets, fed in randomized order for six weeks at a time over the course of 24 weeks. The diets contained: At least 25 grams of animal protein a day At least 25 grams of isolated soy protein Either trace amounts or 50 mg of soy isoflavones Researchers found that soy significantly reduced total and LDL cholesterol and triglyceride levels in participants with very high cholesterol levels. However, it had only a modest effect on those participants with elevated, but not severely high, cholesterol. They concluded, Although potentially helpful when used to displace products containing animal fat from the diet, the regular intake of relatively high levels of soy protein had only a modest effect on blood cholesterol levels and only in subjects with elevated LDL cholesterol levels. Soy-derived isoflavones had no significant effect. In other words, eating soy (but NOT taking a supplement) helps those people with elevated cholesterol, but doesnt really help someone with moderately high cholesterol. What the researchers fail to mention is that simply reducing the consumption of animal protein (particularly with no regard for the quality of that animal protein), regardless of the soy substitute, may have had the same effect. It would be interesting to see the results of that type of study. A similar study from the November 2001 issue of Archives of Internal Medicine3 followed more than 9,600 men and women for 19 years. They found that those who ate legumes (all legumes, not just soy) four times or more per week (compared to less than once a week) enjoyed a 22 percent lower risk of coronary heart disease and an 11 percent lower risk of cardiovascular disease. Researchers concluded that increased legume intake may be an important part of a dietary approach to preventing cardiovascular heart disease. What is interesting about this study is that it includes all legume consumption, not just soy. And since legumes (beans, peas, etc.) are high in fiber, it could be the legumes themselves, not the soy per se, that is responsible for the decreased risk of heart disease. Still, it was these types of studies that, in 1999, led the FDA to authorize of the use of health claims on the labeling of foods containing soy protein. Natural Health Sherpa Soy 21
The ruling was based on research that suggested such foods might reduce the risk of coronary heart disease by lowering blood cholesterol levels. According to the FDA, foods must contain 6.25 grams per serving of soy protein in order to qualify for the claim. And a daily intake of 25 grams is recommended to achieve a significant cholesterol-lowering effect. While the studies surrounding cholesterol and soy are compelling, there are several obvious questions that remain. Lets see if the studies regarding soy and menopause symptoms can help answer those questions.
Soy
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Soy
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and thymus removed. This is important, because your ovaries and thymus produce estrogen. By removing these, researchers were trying to ensure that any estrogen effects were coming from the soy. Researchers found that genistein either negated or overwhelmed the inhibitory effect of tamoxifen. Based on these findings, they urged postmenopausal women to exercise caution when consuming dietary genistein while taking tamoxifen. In other words, these researchers believe that women taking tamoxifen to help stop the growth or spread of breast cancer would completely undo the positive effects of the medicine by eating soy.
more than in the infants taking the breast milk. Researchers concluded that the daily exposure of infants to isoflavones in soy infant formulas is six to 11 fold greater on a bodyweight basis than the dose that has hormonal effects in adults consuming soy foods. Worse yet, they go on to say that circulating concentrations of isoflavones in the seven infants fed soy-based formula were 13,000 to 22,000 times higher than plasma oestradiol concentrations in early life, and may be sufficient to exert biological effects. Wow! Thats a lot of unnatural estrogen floating around in those little bodies. And we wonder why girls are developing so much earlier than they did 20 years ago, and why boys seem to be behind the curve. Could it be all that excess estrogen? Finally, those who are opposed to soy also point to a number of soy allergies and digestive problems soy can cause, including gas, cramping, bloating, or intestinal discomfort, all of which are signals that our bodies send us to indicate that the use of soy may not be in our best interest.
cervical or ovarian cancer thyroid or family history of thyroid disease soy allergies problems digesting soy or other legumes For this small population, soy may confer some benefit. If you fit into this group, avoid soy supplements and processed soy foods and limit your soy consumption to organic soybeans (edamame) and organic, fermented soy foods, such as: tempeh miso tamari natto. For everyone else, however, just say no to soy. If you would think twice about popping a few birth control pills at lunch or slugging back some hormone replacement pills with dinner, then you shouldnt be using soy either. Treat soy like the true estrogen it is.
References:
Anderson, JW et al. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995. 333:276-82.
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Lichtenstein, AH et al. Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arteriosclerosis, Thrombosis, and Vascular Biology. 2002. 22:1852-8.
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Bazzano, LA et al. Legume consumption and risk of coronary heart disease in US men and women. Arch Intern Med. 2001. 161:2573-8.
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Ferrari, A. Soy extract phytoestrogens with high dose of isoflavones for menopausal symptoms. J Obstet Gynaecol Res. 2009, Dec. 35(6):1083-90.
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Carmignani, LO et al. The effect of dietary soy supplementation compared to estrogen and placebo on menopausal symptoms: A randomized controlled study. Maturitas. 2010 Sept 10 [Epub ahead of print].
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Sheehan, DM and Doerge, DR. 1999 Feb 18. Letter to FDA in reference to Docket #98P0683.
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Natural Medicine News (L&H Vitamins, 32-33 47th Avenue, Long Island City, NY 11101), 2000 Jan/Feb p. 8.
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Harras, A (ed). Cancer Rates and Risks. National Institutes of Health, National Cancer Institute, 1996. 4th edition.
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Ju, YH et al. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res. 2002 May 1;62(9):2474-7.
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Doerge, DR. Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect. 2002 June; 110 Suppl 3:349-53. Setchell, KD et al. Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet. 1997 Jul 5. 350(9070):23-7.
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