Maya Frankfurt, Ph.D.

Department of Science Education Hofstra North Shore-LIJ School of Medicine 500 Hofstra University , Office# 109 Hempstead, NY 11549 516.463.7502 (w) 718.544. 6798 (h) 917.848.2653 (c) email: maya.frankfurt@hofstra.com EDUCATION 1974 1978 1981 1983 Bronx High School of Science, New York, NY BA, Hampshire College, Amherst, MA M. Phil., The Mount Sinai School of Medicine, CUNY, NY Ph.D., The Mount Sinai School of Medicine, CUNY, NY

TEACHING EXPERIENCE 1986 1988 McGill University, neuroanatomy labs for MD students; neuroendocrinology to undergraduate anatomy students. 1988 1994 Rockefeller University, coordinated and taught neuroanatomy course for Ph.D. and MD/Ph.D. students. Supervised the research of graduate and undergraduate (Hunter College) students. 1993 1994 Stern College- Introductory Biology; Adjunct Professor 1994 1995 William Paterson College; Anatomy and Physiology; Lecture and Laboratory 1995 Barnard College, Physiological Psychology Laboratory, Lab Director 2003 2010 Sophie Davis Medical School, CUNY, Neuroanatomy, Physiology 2007 - 2010 Touro College of Osteopathic Medicine, Course Director Physiology 2010 Professor, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY PROFESSIONAL EXPERIENCE 1979 1983 Mount Sinai School of Medicine, New York, NY Doctoral Thesis 1983 1984 German Primate Center, Goettingen, Germany 1984 1985 Columbia University, New York, NY 1985 1988 Montreal Neurological Institute, McGill University, Montreal 1988 1994 The Rockefeller University, New York, NY, Assistant Professor 1994 1995 William Paterson College, Wayne, NJ , Assistant Professor 1995 Barnard College, Lab Director- Physiological Psychology 1995 2005 Touro College, Associate Professor 2000 2005 Hunter College, Psychology Department, Senior Research Associate 2003 2005 Sophie Davis Medical School, CUNY, Adjunct Medical Professor 2005 - 2010 Research Associate, Sophie Davis Medical School, CUNY 2010 Professor, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY PUBLICATIONS:

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Frankfurt, M., J.M., Lauder and E.C. Azmitia (1981) The immunocytochemical localization serotonergic neurons in the rat hypothalamus, Neuroscience Letters 24:227-232. Frankfurt, M. and E.C. Azmitia (1983) The effect of intracerebral injections of 5,7dihydroxtryptamine and 6-hydroxydopamine on the serotonin immunoreactive cell bodies and fibers in the adult rat hypothalamus, Brain Research 261:91-99. Luine, V.N., M. Frankfurt, T.C. Rainbow, A. Biegon, and E.C. Azmitia (1983) Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases (3H) imipramine binding and 5HT uptake, Brain Research 264:344-349. Frankfurt, M. and E.C. Azmitia (1984) Regeneration of serotonergic fibers in the rat hypothalamus following unilateral 5,7-dihydroxytryptamine injection, Brain Research 298:273-282. Frankfurt, M., E. Fuchs and W. Wuttke (1984) Sex differences in gamma-aminobutyric acid and glutamate concentrations in discrete rat brain nuclei, Neuroscience Letters 50:245-250. Luine., V.N., K. Renner, M. Frankfurt and E.C. Azmitia (1984) Intrahypothalamic raphe transplants reverse facilitation of sexual behavior and restore 5-HT in 5,7-DHT treated rats, Science 226:1436-1439. Frankfurt, M., K. Renner, E.C. Azmitia and V.N. Luine (1985) Intrahypothalamic 5,7dihydroxytryptamine : Temporal analysis of effects on 5HT content in brain nuclei and on facilitated lordosis behavior , Brain Research 340:127-133. Frankfurt, M., R.A. Siegel, I. Sim., W. Wuttke (1986) Cholecystokinin and substance P in discrete areas of the rat brain: sex differences, Brain Research 358:53-58.

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9. Frankfurt, M., R.A. Siegel, I. Sim., W. Wuttke (1986) Estrous cycle variations in cholecystokinin and substance P concentrations in discrete areas of the rat brain, Neuroendocrinology 42:226-231. 10. Lloyd, P.E., M. Frankfurt, P. Stevens, I. Kupfermann and K. Weiss (1987) Biochemical and immunocytochemical localization of the neuropeptides FMRFamide and SCPa and SCPb to neurons involved in the regulation of feeding in Aplysia, J. Neuroscience 7:1123-1132. 11. Frankfurt, M., D.L. Allen , V.N. Luine and A. Beaudet (1987) Temporal effects of intrahypothalamic 5,7-dihydroxytryptamine: relationship between serotonin levels and 3H serotonin binding, Brain Research 419:216-222. 12. Luine, V.N., J. E. Thornton, M. Frankfurt, and N.J. MacLusky (1987) Effects of hypothalamic serotonin depletion on lordosis behavior and gonadal hormone receptors, Brain Research 426:47-54.

13. Frankfurt, M. and A. Beaudet (1987) The ultrastructural organization of regenerated serotonin axons in the dorsomedial hypothalamus of the adult rat, J. Neurocytology 16:799809. 14. Frankfurt, M. and A. Beaudet (1988) Reinnervation of dopamine neurons by regenerated serotonin neurons in the rat medial zona incerta: a combined radioautographic and immunocytochemical ultrastructural study, Experimental Brain Research 72:473-480. 15. Schumacher, M., H. Coirini, M. Frankfurt and B.S. McEwen (1989) Localized actions of progesterone in hypothalamus involve oxytocin PNAS 86:6798-6801. 16. Gould, E., A. Westlind- Danielsson, M. Frankfurt and B.S. McEwen (1990) Sex differences and thyroid - sensitivity of hippocampal pyramidal cells, J. Neuroscience 10:996-1003. 17. Gould, E., C.S. Woolley, M. Frankfurt and B.S. McEwen (1990) Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood, J. Neuroscience 10:1286-1291. 18. Frankfurt, M., E. Gould, C.S. Woolley and B.S. McEwen (1990) Gonadal steroids modify dendritic spine density in ventromedial hypothalamic neurons: a Golgi study in the adult rat, Neuroendocrinology 51:530-535. 19. Gould, E., M. Frankfurt, A. Westlind- Danielsson and B.S. McEwen (1990) Developing forebrain astrocytes are sensitive to thyroid hormone, Glia 3:283-292. 20. Woolley, C.S., E. Gould, M. Frankfurt and B.S. McEwen (1990) Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons, J. Neuroscience 10:4035-4039. 21. Frankfurt, M., J. O'Callaghan and A. Beaudet (1991) 5,7-Dihydroxytryptamine injections increase glial fibrillary acidic protein in the hypothalamus of adult rats. Brain Research 549:138-140. 22. Frankfurt, M. and B.S. McEwen (1991) Estrogen increases axodendritic synapses in the VMN of rats after ovariectomy, Neuroreport 2:380-382. 23. Luine, V.N., J. Cowell and M. Frankfurt (1991) GABAergic-serotonergic interactions in regulating lordosis, Brain Research 556:171-174. 24. Frankfurt, M. and B.S. McEwen (1991) 5,7-Dihydroxytryptamine and gonadal steroid manipulation alter spine density in the ventromedial hypothalamic nucleus. Neuroendocrinology 54:653-657. 25. Schumacher M, Coirini H, Johnson AE, Flanagan LM, Frankfurt M, Pfaff DW, McEwen BS (1991) Steroid hormones as mediators of neural plasticity. J Steroid Biochem Mol Biol . 39(2):223-32.

26. McEwen , B.S., H. Coirini, A . Westlind-Danielsson., M. Frankfurt, E. Gould, S. Mendelson, M. Schmacher, A. Segarra and C.S. Woolley (1991) Steroid and thyroid hormones modulate a changing brain. J. Steroid Biochemistry and Molecular Biology 40:127. Aiello-Zaldivar, M., V.N. Luine and M. Frankfurt (1992) 5,7-DHT-facilitated lordosis: Effects of 5-HT agonists Neuroreport 3:542-544. 28. Frankfurt, M., S.D. Mendelson, C.R. McKittrick and B.S. McEwen (1993) Alterations in serotonin receptor binding in the hypothalamus following acute denervation, Brain Research, 601:349-352. 29. Schumacher, M., Coirini, H., Johnson, A.E., Flanagan, L.M., Frankfurt, M., Pfaff, D.W., McEwen,B.S. (1993) The oxytocin receptor: a target for steroid hormones Regul Pept. 45(12):115-9. 30. Frankfurt, M., C.R. McKittrick,S.D. Mendelson and B.S. McEwen (1994) Effects of 5,7dihydroxytryptamine, ovariectomy and gonadal steroids on serotonin receptor binding, Neuroendocrinology 59:245-250. 31. Frankfurt, M., C.R. McKittrick and V.N. Luine (1994) Short-term fluoxetine treatment alters monoamine levels and turnover in discrete brain nuclei, Brain Research: 650:127-132. 32. Chao, H.M., R.L. Spencer, M. Frankfurt and B.S. McEwen (1994) The effects of aging and hormonal manipulations on amyloid precursor protein APP695 mRNA expression in the rat hippocampus, J. Neuroendocrinology, 6:517-521. 33. Lewis, C, McEwen, B.S., Frankfurt, M. (1995) Estrogen-induction of dendritic spines in ventromedial hypothalamus and hippocampus: effects of neonatal aromatase blockade and adult castration, Dev. Brain Research, 87:91-95. 34. Frankfurt, M., McKittrick, C.R., McEwen, B.S. and Luine V.N. (1995) Tianeptine induces regionally specific changes in monoamines, Brain Research 696:1-6. 35. McEwen, B.S., Conrad, C.D., Kuroda, Y., Frankfurt M., Magarinos, A.M. and McKittrick, C. (1997) Prevention of stress-induced morphological and cognitive consequences, European Pyschoparmacology 7, suppl 3, s323-328. 36. Bowman, R.E., MacLusky, J.J. Sarmiento, Y., Frankfurt, M., Gordon, M. and Luine, V.N. (2004) Sexually dimorphic effects of prenatal stress on cognition, hormonal responses and central neurotransmitters. Endocrinology 145:3778-87. Wallace, M., Luine, V., Arellanos, and Frankfurt, M. (2006) Ovariectomized rats show decreased recognition memory and spine density in hippocampus and prefrontal cortex. Brain Res. 1126(1):176-82. 38. Luine, V., Attalla, S., Mohan, G, Costa, A. and Frankfurt, M. (2006) Dietary phytoestrogens

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enhance spatial memory and spine density in the hippocampus and prefrontal cortex of ovariectomized rats. Brain Res. 1126(1):183-7. 39. Zhen X, Goswami S, Abdali SA, Frankfurt M, Friedman E. (2007) Estrogen-modulated frontal cortical CaMKII activity and behavioral supersensitization induced by prolonged cocaine treatment in female rats. Psychopharmacology 191:323331 40. Luine, V.N., Beck, K.D., Bowman, R.E., Frankfurt, M., MacLusky, N.J. (2007) Chronic sress and neural function: accounting for sex and age. J. Neuroendocrinol. 19: 743-751. 41 Wang H.Y., Frankfurt, M, Burns, L.H. (2008) High-affinity naloxone binding to filamin A prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence. PLoS ONE 3(2) e 1534 doi: 10.1371/journal.pone.00001554 42. Frankfurt, M., Wang, H.Y. Marmolejo, N., Bakshi, K., Friedman, E. (2009) Prenatal Cocaine increases dendritic spine density in cortical and subcortical brain regions of the rat. Dev. Neurosci., 31: 71-75 43. Wang HY, Bakshi K, Shen C, Frankfurt M, Trocm-Thibierge C, Morain P. (2010) S 24795 Limits beta-Amyloid-alpha7 Nicotinic Receptor Interaction and Reduces Alzheimer's Disease-Like Pathologies. Biol Psychiatry. 67(6):522-30. 44 . Salas-Ramirez, K., Frankfurt, M., Alexander, A., Luine, V and Friedman, E. (2010) Prenatal cocaine exposure increases anxiety, impairs cognitive function and increases dendritic spine density in adult rats: influence of sex. Neuroscience 169:1287-95.. 45. Frankfurt, M., Salas- Ramirez, K., Friedman, E. and Luine, V. (2011) Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat. Synapse 65:955961. 46. Luine, V.N., Wallace, ME and Frankfurt, M., Age-related deficits in spatial memory and hippocampal spines in virgin, female fischer 344 rats, Current Gerontology and Geriatrics Research, vol. 2011, Article ID 316386, 7 pages, 2011. doi:10.1155/2011/316386
47. Eilam-Stock, T., Serrano, P., Frankfurt M. and Luine, V., Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats, Behav. Neurosci., in press

CHAPTERS: Luine, V.N., K. Renner, M. Frankfurt and E.C. Azmitia (1985) Raphe transplants into the hypothalamus reverse facilitation of sexual behavior of 5,7-DHT treated rats: immunocytochemical, neurochemical, and behavioral studies. In: Neural Grafting in the Mammalian CNS, A. Bjorklund and U. Stenevi (Eds.) Elsevier Science Publications, PP 655662. Seigel, R.A., M. Frankfurt, U. Pahnke and W. Wuttke (1985) Cholecystokinin in discrete rat brain regions as a function of sex and estrous cycle. In: Neuronal Cholecystokinin, J.J.

Vanderhaegen and J.N. Crawley (Eds.) , New York Academy of Science, vol 448, pp 651653. McEwen, B.S., H. Coirini, M. Frankfurt, J. Gerlach, A. Johnson, and M. (1989) Neuronal gonadal steroid receptors and actions: chemical anatomy of the ventromedial hypothalamus in relation to sexual differentiation and sexual behavior. In: Life Sciences, Birkhauser Congress Reports, J. Carlsfeldt-Duke, , H., Erikkson, J. -A. Gustafsson (Eds.) Birkhauser Verlag, Basal, pp 263-270. Azmitia,. E., M. Frankfurt, M. Davila, P. Whitaker-Azmitia and F. Zhou (1990) Plasticity of fetal and adult serotonergic neurons: Role of Growth regulatory factors. Annals of New York Academy of Sciences, vol 600, pp 343-365. Schmacher, M., H. Coirini, M. Frankfurt and B.S. McEwen (1990) The neuronal membrane: A target for steroid hormone action. In Hormones. Brain and Behavior in Vertebrates 2. Behavioral activation in males and females- social interaction and reproductive biology edited by J. Balthazart. Karger: pp91-115 Schmacher, M., H. Coirini, L.M. Flanagan, M. Frankfurt, D.W. Pfaff and B.S. McEwen (1992) Ovarian steroid modulation of oxytocin receptor binding in the ventromedial hypothalamus, Annals of New York Academy of Sciences, vol 652, pp 374 - 386. Frankfurt, M. (1994) Gonadal Steroids and Neural Plasticity: Studies in the Adult Rat Hypothalamus. In "Hormonal Restructuring of the Adult Brain" edited by V.N. Luine and C. Harding, Ann. N.Y. Acad . Sci. 743: 45-60. Wallace, M, Frankfurt, M., Arellanos, A., Inagaki, T and Luine, V. (2007) Impaired recognition memory and decreased frontal cortex spine density in aged rats. In Imaging and the Aging Brain . Ann. N.Y. Acad . Sci. 1097: 54-57. Luine, VN and Frankfurt, M., An Integrative Review of Estradiol Effects on Dendritic Spines and Memory over the Lifespan, In "Sex Steroids", ISBN 978-953-307-857-1, Book edited by: Dr. Scott M. Kahn,Intech Open Access Publishing, in press

RECENT ABSTEACTS Inagaki, T.,Frankfurt, M., Friedman E., Luine V. (2007) Acute bisphenol-A causes opposite effects on estrogen-induced memory enhancement and spine density: A membrane receptor agonist? Soc. Neurosci 207.18 San Diego Marmolejo, N.,. Wang, H. Y., Tehrani, N. Stucky, A, Friedman, E and Frankfurt, M. (2008) Effects of cocaine and estrogen on neurotrophin receptor signaling in the hippocampus of ovariectomized rats Soc. Neurosci 359.24 Washington D.C.

Monde, K. Frankfurt, M., Zherebchuk, S, Matthew, T., Mohan, G., Luine, V.N. (2008). Relationships between spatial memory, estradiol, and spine density in the hippocampus and frontal cortex of rats- Soc. Neurosci 675.4 Washington D.C. Salas-Ramirez, K., Stahl, L., Frankfurt, M., Friedman, E., Luine, V.N. (2010) Adult cocaine exposure results in transient cognitive deficits in both male and female rats Soc. Neurosci Abst. San Diego Eilam-Stock, T., Serrano, P, Frankfurt,M., Luine, V.N. Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats. Program No. 715.11, Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011. Gomez, J.L., Lewis, M.J. , Frankfurt, M., Serrano, P Luine, V. Post-Stress Alcohol Treatment Alleviates Stress-Induced Memory Impairments in Male Rats. Program No. 469.11, Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011