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TABLE OF CONTENTS
Introduction...........................................................................................................................1
Background...................................................................................................................... 2
Addressing Data Needs.................................................................................................... 3
Public Health Uses........................................................................................................... 3
Data Presented for Biochemical Indicators....................................................................... 4
Interpreting the Data....................................................................................................... 5
Sources of Information on Nutrition Monitoring to Help Interpret the Data................... 6
The National Health and Nutrition Examination Survey (NHANES).............................. 7
Data Analysis................................................................................................................... 7
References...................................................................................................................... 10
1 Water-Soluble Vitamins.....................................................................................................13
B Vitamins and Related Biochemical Compounds............................................................ 14
Background Information................................................................................................ 14
Highlights...................................................................................................................... 18
Figure H.1.a
Figure H.1.b
Figure H.1.c
Figure H.1.d
Detailed Observations.................................................................................................... 20
Table 1.1.a.1
Figure 1.1.a
Tables 1.1.a.25
Table 1.1.b
Figure 1.1.b
Table 1.2.a.1
Figure 1.2.a
Tables 1.2.a.25
Table 1.2.b
Figure 1.2.b
Table 1.2.c
Table 1.2.d
Table 1.3.a.1
Figure 1.3.a
Tables 1.3.a.25
Table 1.3.c
Table 1.4.a.1
Figure 1.4.a.
Tables 1.4.a.25
Table of Contents
Table 1.5.a.1
Figure 1.5.a
Tables 1.5.a.25
Table 1.5.b
Figure 1.5.b
Table 1.5.c
Table 1.5.d
Table 1.6.a.1
Figure 1.6.a
Tables 1.6.a.25
Table 1.6.b
Figure 1.6.b
Table 1.6.c
Table 1.6.d
Table 1.7.a.1
Figure 1.7.a
Tables 1.7.a.25
Table 1.7.b
Figure 1.7.b
Table 1.7.c
Table 1.7.d
Figure H.1.e
References...................................................................................................................... 70
Vitamin C......................................................................................................................... 72
Background Information ............................................................................................... 72
Highlights...................................................................................................................... 74
Figure H.1.f
Detailed Observations.................................................................................................... 75
Table 1.8.a.1
Figure 1.8.a
Tables 1.8.a.25
Table 1.8.b
Figure 1.8.b
Table 1.8.c
Table 1.8.d
References...................................................................................................................... 84
2 Fat-Soluble Vitamins and Nutrients...................................................................................87
Vitamins A and E and Carotenoids................................................................................... 88
Background Information................................................................................................ 88
Highlights...................................................................................................................... 91
Figure H.2.a
Detailed Observations.................................................................................................... 92
Table 2.1.a.1
Figure 2.1.a
Tables 2.1.a.25
Table 2.1.b
Figure 2.1.b
Table 2.1.c.1
Table 2.1.c.2
Table 2.1.d.1
Table 2.1.d.2
ii
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Table 2.2.a.1
Figure 2.2.a
Tables 2.2.a.25
Table 2.2.b
Figure 2.2.b
Table 2.3.a.1
Tables 2.3.a.25
Table 2.3.b
Figure 2.3.b
Table 2.4.a.1
Figure 2.4.a
Tables 2.4.a.25
Table 2.4.b
Figure 2.4.b
Table 2.4.c
Table 2.4.d
Table 2.5.a.1
Figure 2.5.a
Tables 2.5.a.25
Table 2.5.b
Figure 2.5.b
Table 2.6.a.1
Figure 2.6.a
Tables 2.6.a.25
Table 2.6.b
Figure 2.6.b
Table 2.7.a.1
Figure 2.7.a
Tables 2.7.a.25
Table 2.7.b
Figure 2.7.b
Table 2.8.a.1
Tables 2.8.a.25
Table 2.8.b
Figure 2.8.b
Table 2.9.a.1
Figure 2.9.a
Tables 2.9.a.25
Table 2.9.b
Figure 2.9.b
Table 2.10.a.1
Figure 2.10.a
Tables 2.10.a.25
Table 2.10.b
Figure 2.10.b
Figure 2.11.a.1
Figure 2.11.a
Tables 2.11.a.25
Table 2.11.b
Figure 2.11.b
Table 2.12.a.1
Figure 2.12.a
Tables 2.12.a.25
References.................................................................................................................... 170
Table of Contents
iii
Figure H.2.e
References.................................................................................................................... 192
Fatty Acids...................................................................................................................... 193
Background Information.............................................................................................. 193
Highlights.................................................................................................................... 196
Figure H.2.f
Figure H.2.g
iv
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Table 2.19.a.1
Plasma lignoceric acid (24:0): Concentrations....................................................220
Figure 2.19.a
Plasma lignoceric acid (24:0): Concentrations by age group...............................221
Tables 2.19.a.25 Plasma lignoceric acid (24:0): Concentrations by race/ethnic group...................222
Table 2.20.a.1
Plasma myristoleic acid (14:1n-5): Concentrations.............................................224
Figure 2.20.a
Plasma myristoleic acid (14:1n-5): Concentrations by age group........................225
Tables 2.20.a.25 Plasma myristoleic acid (14:1n-5): Concentrations by race/ethnic group............226
Table 2.21.a.1
Plasma palmitoleic acid (16:1n-7): Concentrations.............................................228
Figure 2.21.a
Plasma palmitoleic acid (16:1n-7): Concentrations by age group........................229
Tables 2.21.a.25 Plasma palmitoleic acid (16:1n-7): Concentrations by race/ethnic group............230
Table 2.22.a.1
Plasma cis-vaccenic acid (18:1n-7): Concentrations............................................232
Figure 2.22.a
Plasma cis-vaccenic acid (18:1n-7): Concentrations by age group.......................233
Tables 2.22.a.25 Plasma cis-vaccenic acid (18:1n-7): Concentrations by race/ethnic group...........234
Table 2.23.a.1
Plasma oleic acid (18:1n-9): Concentrations.......................................................236
Figure 2.23.a
Plasma oleic acid (18:1n-9): Concentrations by age group..................................237
Tables 2.23.a.25 Plasma oleic acid (18:1n-9): Concentrations by race/ethnic group......................238
Table 2.24.a.1
Plasma eicosenoic acid (20:1n-9): Concentrations..............................................240
Figure 2.24.a
Plasma eicosenoic acid (20:1n-9): Concentrations by age group.........................241
Tables 2.24.a.25 Plasma eicosenoic acid (20:1n-9): Concentrations by race/ethnic group.............242
Table 2.25.a.1
Plasma docosenoic acid (22:1n-9): Concentrations.............................................244
Figure 2.25.a
Plasma docosenoic acid (22:1n-9): Concentrations by age group........................245
Tables 2.25.a.25 Plasma docosenoic acid (22:1n-9): Concentrations by race/ethnic group............246
Table 2.26.a.1
Plasma nervonic acid (24:1n-9): Concentrations................................................248
Figure 2.26.a
Plasma nervonic acid (24:1n-9): Concentrations by age group...........................249
Tables 2.26.a.25 Plasma nervonic acid (24:1n-9): Concentrations by race/ethnic group...............250
Table 2.27.a.1
Plasma linoleic acid (18:2n-6): Concentrations...................................................252
Figure 2.27.a
Plasma linoleic acid (18:2n-6): Concentrations by age group..............................253
Tables 2.27.a.25 Plasma linoleic acid (18:2n-6): Concentrations by race/ethnic group..................254
Table 2.28.a.1
Plasma alpha-linolenic acid (18:3n-3): Concentrations.......................................256
Figure 2.28.a
Plasma alpha-linolenic acid (18:3n-3): Concentrations by age group..................257
Tables 2.28.a.25 Plasma alpha-linolenic acid (18:3n-3): Concentrations by race/ethnic group......258
Table 2.29.a.1
Plasma gamma-linolenic acid (18:3n-6): Concentrations....................................260
Figure 2.29.a
Plasma gamma-linolenic acid (18:3n-6): Concentrations by age group...............261
Tables 2.29.a.25 Plasma gamma-linolenic acid (18:3n-6): Concentrations by race/ethnic group...262
Table 2.30.a.1
Plasma eicosadienoic acid (20:2n-6): Concentrations.........................................264
Figure 2.30.a
Plasma eicosadienoic acid (20:2n-6): Concentrations by age group.....................265
Tables 2.30.a.25 Plasma eicosadienoic acid (20:2n-6): Concentrations by race/ethnic group.........266
Table 2.31.a.1
Plasma homo-gamma-linolenic acid (20:3n-6): Concentrations...........................268
Figure 2.31.a
Plasma homo-gamma-linolenic acid (20:3n-6): Concentrations by age group......269
Tables 2.31.a.25 Plasma homo-gamma-linolenic acid (20:3n-6): Concentrations by race/ethnic
group..................................................................................................................270
Table 2.32.a.1
Plasma arachidonic acid (20:4n-6): Concentrations............................................272
Figure 2.32.a
Plasma arachidonic acid (20:4n-6): Concentrations by age group.......................273
Tables 2.32.a.25 Plasma arachidonic acid (20:4n-6): Concentrations by race/ethnic group...........274
Table 2.33.a.1
Plasma eicosapentaenoic acid (20:5n-3): Concentrations....................................276
Figure 2.33.a
Plasma eicosapentaenoic acid (20:5n-3): Concentrations by age group...............277
Tables 2.33.a.25 Plasma eicosapentaenoic acid (20:5n-3): Concentrations by race/ethnic group...278
Table 2.34.a.1
Plasma docosatetraenoic acid (22:4n-6): Concentrations....................................280
Figure 2.34.a
Plasma docosatetraenoic acid (22:4n-6): Concentrations by age group...............281
Tables 2.34.a.25 Plasma docosatetraenoic acid (22:4n-6): Concentrations by race/ethnic group...282
Table of Contents
Table 2.35.a.1
Plasma docosapentaenoic-3 acid (22:5n-3): Concentrations...............................284
Figure 2.35.a
Plasma docosapentaenoic-3 acid (22:5n-3): Concentrations by age group..........285
Tables 2.35.a.25 Plasma docosapentaenoic-3 acid (22:5n-3): Concentrations by race/ethnic
group..................................................................................................................286
Table 2.36.a.1
Plasma docosapentaenoic-6 acid (22:5n-6): Concentrations...............................288
Figure 2.36.a
Plasma docosapentaenoic-6 acid (22:5n-6): Concentrations by age group..........289
Tables 2.36.a.25 Plasma docosapentaenoic-6 acid (22:5n-6): Concentrations by race/ethnic
group..................................................................................................................290
Table 2.37.a.1
Plasma docosahexaenoic acid (22:6n-3): Concentrations....................................292
Figure 2.37.a
Plasma docosahexaenoic acid (22:6n-3): Concentrations by age group...............293
Tables 2.37.a.25 Plasma docosahexaenoic acid (22:6n-3): Concentrations by race/ethnic
group..................................................................................................................294
References.................................................................................................................... 296
3 Trace Elements.................................................................................................................299
Iron-Status Indicators..................................................................................................... 300
Background Information.............................................................................................. 300
Highlights.................................................................................................................... 303
Figure H.3.a
Figure H.3.b
Figure H.3.c
Figure H.3.d
vi
Table 3.1.a.1
Figure 3.1.a
Tables 3.1.a.25
Table 3.1.b
Figure 3.1.b
Table 3.1.c.1
Table 3.1.c.2
Table 3.1.c.3
Table 3.1.d.1
Table 3.1.d.2
Table 3.1.d.3
Table 3.1.d.4
Table 3.1.d.5
Table 3.2.a.1
Figure 3.2.a
Tables 3.2.a.25
Table 3.2.b
Figure 3.2.b
Table 3.2.c
Table 3.2.d
Table 3.3.a.1
Figure 3.3.a
Tables 3.3.a.25
Table 3.3.b
Figure 3.3.b
Table 3.3.c.1
Table 3.3.c.2
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Table 3.3.d.1
Table 3.3.d.2
Body iron: Prevalence by survey cycle (< 0 mg/kg for children) .........................338
Body iron: Prevalence by survey cycle (< 0 mg/kg for women) ...........................339
Figure H.3.e
References.................................................................................................................... 340
Iodine............................................................................................................................. 342
Background Information.............................................................................................. 342
Highlights.................................................................................................................... 344
Figure H.3.f
Table 3.5.a.1
Figure 3.5.a
Tables 3.5.a.25
Table 3.5.b
Figure 3.5.b
References.................................................................................................................... 358
4 Isoflavones and Lignans...................................................................................................361
Background Information.............................................................................................. 362
Highlights.................................................................................................................... 364
Figure H.4.a
Table 4.2.a.1
Figure 4.2.a
Tables 4.2.a.25
Table 4.2.b
Figure 4.2.b
Table 4.3.a.1
Figure 4.3.a
Tables 4.3.a.25
Table 4.3.b
Figure 4.3.b
Table 4.4.a.1
Figure 4.4.a
Tables 4.4.a.25
Table 4.4.b
Figure 4.4.b
Table 4.5.a.1
Figure 4.5.a
Tables 4.5.a.25
Table 4.5.b
Figure 4.5.b
Table of Contents
vii
Table 4.6.a.1
Figure 4.6.a
Tables 4.6.a.25
Table 4.6.b
Figure 4.6.b
Table 4.7.a.1
Figure 4.7.a
Tables 4.7.a.25
Table 4.7.b
Figure 4.7.b
Table 4.8.a.1
Figure 4.8.a
Tables 4.8.a.25
Table 4.8.b
Figure 4.8.b
Table 4.9.a.1
Figure 4.9.a
Tables 4.9.a.25
Table 4.9.b
Figure 4.9.b
Table 4.10.a.1
Figure 4.10.a
Tables 4.10.a.25
Table 4.10.b
Figure 4.10.b
Table 4.11.a.1
Figure 4.11.a
Tables 4.11.a.25
Table 4.11.b
Figure 4.11.b
Table 4.12.a.1
Figure 4.12.a
Tables 4.12.a.25
Table 4.12.b
Figure 4.12.b
References.................................................................................................................... 438
5 Acrylamide Hemoglobin Adducts....................................................................................443
Background Information.............................................................................................. 444
Highlights.................................................................................................................... 445
Figure H.5.a
Table 5.2.a.1
Figure 5.2.a
Tables 5.2.a.25
Table 5.3.a.1
Figure 5.3.a
Tables 5.3.a.25
viii
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
References.................................................................................................................... 461
Appendices.........................................................................................................................465
Appendix A: NHANES Reports Related to Nutritional Status..................................... 466
Appendix B: Information Presented in the Report........................................................ 468
Appendix C: Cutoff Values Used to Generate Prevalence Estimates.............................. 470
Appendix D: References for Analytical Methods for Biochemical Indicators................ 471
Appendix E: Confidence Interval Estimation for Percentiles......................................... 473
Appendix F: Limit of Detection Table.......................................................................... 478
Appendix G: Selected References of Descriptive NHANES Papers on
Diet-and-Nutrition Biochemical Indicators........................................................... 480
* crea corr, creatinine corrected
** ODMA, O-desmethylangolensin
Table of Contents
ix
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Introduction
Background
Addressing Data Needs
Public Health Uses
Data Presented for Each Biochemical Indicator
Interpreting the Data
Useful Sources of Information about Using Nutrition
Monitoring to Interpret Data
The National Health and Nutrition Examination
Survey (NHANES)
Data Analysis
References
Introduction
Introduction
Background
The National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
is a series of publications that provide ongoing assessment of the U.S. populations nutritional
status by measuring blood or urine concentrations of diet-and-nutrition biochemical indicators.
The Centers for Disease Control and Preventions (CDC) Division of Laboratory Sciences at the
National Center for Environmental Health (NCEH/DLS) conducted the laboratory analyses
for 58 biochemical indicators presented in this 2012 report, which is the second in this series.
CDC measured these indicators in specimens from a representative sample of the U.S. population
during all or part of the four-year period from 2003 through 2006. Where available, data are also
presented on changes of biochemical indicator concentrations over time since 1999. Similarly,
data are also presented on the prevalence of low or high biochemical indicator concentrations
during 20032006, and on changes in the prevalence over time since 1999. The first report of this
series was published in July 2008 and contains information on 27 biochemical indicators from
all or part of the four-year period from 1999 through 2002. Both reports can be accessed online:
http://www.cdc.gov/nutritionreport.
Characteristic
Years of NHANES covered
Number of indicators covered
Concentrations by race/ethnic group
Central 95% reference intervals
Graphic representation of age patterns
Concentrations over time
Prevalence estimates
Prevalence estimates over time
19992002
27
Yes
No
No
No
No
No
20032006
58
Yes
Yes
Yes
Yes (1999-2006)
Yes
Yes (1999-2006)
CDCs National Health and Nutrition Examination Survey (NHANES), conducted by the
National Center for Health Statistics (NCHS), collected the specimens for this report. NHANES
is a series of surveys designed to collect data on the health and nutritional status of the U.S.
population. This report covers biochemical measurementsone important facet in the assessment
of the U.S. populations nutritional status. Other nutrition-related aspects from NHANES,
such as dietary intake, supplement usage, hematologic measurements, and anthropometric body
measurements are not covered.
In this report, a biochemical indicator means a nutrient (e.g., vitamin, fatty acid, trace element),
a metabolite (e.g., homocysteine, methylmalonic acid), or a dietary indicator with potential
health relevance (e.g., isoflavone, lignan) measured in blood or urine. Although most biochemical
indicators presented in this report enter the human body from foods or supplements, the body
itself produces some indicators in response to dietary intake or environmental exposure. Blood
and urine concentrations reflect the amount of nutrients and dietary compounds actually in the
body or passing through the body from all these sources.
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
The biochemical indicator sections and new biochemical indicators covered in this report are:
Water-soluble vitamins
Fat-soluble vitamins and nutrients
Trace elements (iron indicators and iodine)
Isoflavones and lignans
Acrylamide hemoglobin adducts
Vitamin B6
Vitamin C
Fatty acids
Iron status: Transferrin receptor and body iron
Acrylamide hemoglobin adducts
Introduction
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
For biochemical indicators that have accepted cutoff values for low or high concentrations or
for both (e.g., folate, vitamins A, B6, B12, C, D, E, ferritin, iodine)suggesting deficiency or
excess of certain micronutrientswe present tables with prevalence estimates by age, gender, or
race/ethnicity during all or part of 20032006 (1-level stratified). We also present tables with
prevalence estimates by age, gender, or race/ethnicity for each available two-year survey cycle from
19992006 to allow evaluation of changes in prevalence estimates over time (1-level stratified).
See Appendix C for a complete listing of the cutoff values and populations described in this
report.
Background text provides general information for each indicator to aid with interpreting the data.
To address sources of these nutrients, biochemical pathways in the body, and known health
effects, the text contains a brief overview about each indicator.
Each chapter contains highlights followed by detailed observations that are derived from this reports
data tables and figures.
The highlights are presented directly after the background text. They summarize important
observations and discuss them in a public health context. For example, we present figures
highlighting prevalence information by demographic subgroups. Where long-term trending
information beyond the continuous NHANES is available and of public health interest, we
present figures showing changes in biochemical indicator concentrations from NHANES III
(19881994) to NHANES 19992002 and NHANES 20032006. The detailed observations
describe selected categorical differences between demographic subgroups derived from the data
tables and figures that follow next. Each chapter is concluded by a list of pertinent references.
Introduction
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Data Analysis
NCHS has developed a comprehensive Web-based tutorial (http://www.cdc.gov/nchs/tutorials/
Nhanes/index.htm) to help users better understand the complex survey design and to help them
analyze NHANES data.
Because the NHANES sample design is a complex, multistage probability sample, officials
use sample weights when estimating the mean or other descriptive metrics. These weights are
post-stratified to the U.S. Census Bureau estimates of the U.S. population to adjust for the
unequal probability of selection into the survey and possible bias resulting from nonresponse.
Demographic data files released by NCHS for each NHANES two-year survey cycle include a
two-year interview weight and a medical examination weight. All estimates in this report use the
appropriate medical examination weight. The selected medical examination weight depends on
whether the specimens tested constitute a random subsample of all the eligible participants and
how many survey cycles are combined to produce the estimate.
Introduction
Combining data over multiple survey cycles can produce estimates with increased statistical
reliability. In cases of combined estimates, new weights were constructed. For example, a four-year
estimate for the years 20032006 was based on a four-year weight, which was created by assigning
half the two-year weight for 20032004 or half the two-year weight for 20052006, depending
when the person was sampled.
Results are shown for the total population and by age group, gender, and race/ethnicity, as defined
in NHANES. For these analyses, race/ethnicity is presented as Mexican American, non-Hispanic
black, and non-Hispanic white. Other racial or ethnic groups are sampled, but the proportion
of the total population represented by these other groups is not large enough to produce valid
estimates. Thus, this report does not include separate estimates for other racial subcategories. The
other racial/ethnic groups, however, are included in the overall estimates.
Data were analyzed by use of the statistical software package Statistical Analysis System (SAS,
Version 9.2) and SUDAAN (Release 10.0). SUDAAN uses sample weights and calculates variance
estimates that account for the complex survey design. Guidelines for the analysis of NHANES
data are provided by NCHS at: http://www.cdc.gov/nchs/nhanes/nhanes2003-2004/analytical_
guidelines.htm.
Standard error estimates were calculated by use of the Taylor series (linearization) method within
SUDAAN. The degrees of freedom for variance estimation are generated by subtracting the
number of strata from the number of primary sampling units (PSUs).
Geometric means were calculated by taking the log of each concentration, calculating the mean
of those log values, then taking the antilog of that mean (the calculation can be done by use of
any log base, such as 10 or e). The confidence interval uses the standard error and mean on the
log scale and the appropriate critical value from the t-distribution to calculate upper and lower
confidence limits on the log scale. The confidence intervals of geometric means in this report are
based on taking the antilog of those upper and lower confidence intervals.
Percentile estimates were calculated by use of linear interpolation. Confidence intervals for
percentiles were calculated by the Woodruff method (1952). This method uses the standard error
of the empirical distribution function at the selected percentile and constructs a 95% confidence
interval, followed by back-transforming by use of the inverse of the empirical distribution (see
Appendix E for more details). We used the unweighted sample size and assumed an average
design effect of 1.4 as the criteria to estimate percentiles of sufficient precision (U.S. Centers for
Disease for Control and Prevention 1996; Table 1 in Appendix B). In order for percentiles to be
considered reliable, at least 112 persons had to be represented to allow estimation of the 10th and
90th percentiles, 224 persons for the 5th and 95th percentiles, and 448 persons for the 2.5th and
97.5th percentiles. We flagged and footnoted percentiles where these requirements were not met.
Prevalence estimates for low or high concentrations of biochemical indicators are the weighted
percentage of persons who fall below or above a predefined cutoff value (see Appendix C). The
confidence intervals for prevalence estimates are based on a logit transformation that ensures
the confidence interval limits cannot fall outside of 0 and 1. We used the relative standard error
(RSE) as a criterion for prevalence estimates of sufficient precision. The RSE is calculated as a
percentage by dividing the standard error of the estimate by the estimate value and multiplying by
100. Prevalence estimates associated with a RSE between 30% and less than 40% are flagged and
footnoted in this report. Estimates are not provided if they are associated with an RSE equal to or
greater than 40%.
8
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Estimates of the total number of persons who met the definition of having low or high
concentrations of biochemical indicators were generated by multiplying the weighted prevalence
estimate by the population size of interest, derived from the current population survey (CPS) at
the midpoint of the available two-year cycle. Confidence intervals for the estimated total, while
not presented, are calculated by multiplying the population size of interest by the upper and
lower limits of the 95% confidence interval for the weighted prevalence. CPS-based population
tables for NHANES by age, gender, and race/ethnicity are on the NHANES Web page for a
given survey cycle, available at http://www.cdc.gov/nchs/nhanes/response_rates_CPS.htm. When
estimates of the total count are based on combined survey cycles (20032006), the 20032004
CPS-based population table at the above link was used.
Figures in the highlight section that present age-adjusted geometric mean concentrations from
NHANES III (19881994), NHANES 19992002, and NHANES 20032006 or age-adjusted
prevalence estimates by demographic subgroups have been generated in SUDAAN by use of agestandardizing proportions from the 2000 U.S. Census population (using direct standardization).
Statistically significant differences between age-adjusted geometric means and age-adjusted
prevalences were assessed through pairwise comparisons. A reader should take care when
interpreting these age-adjusted figures in isolation. The magnitude of an age-adjusted geometric
mean or age-adjusted prevalence is completely arbitrary, and it depends upon the chosen standard
population. Additionally, age-adjusted geometric means or age-adjusted prevalences can mask
important information about trends if age-specific rates do not have a consistent relationship.
It is worth noting that while NHANES 19992004 provided a race/ethnicity variable that was
an analytic link to the NHANES III race/ethnicity variable called RIDRETH2, this variable is
not included in the NHANES 20052006 demographics file. Therefore, the codes of the race/
ethnicity variable called RIDRETH1 were used in displaying age-adjusted geometric means by
race/ethnicity for NHANES 19992002 and NHANES 20032006. RIDRETH1 includes
all multi-racial responses in the Other category; whereas, RIDRETH2 includes multi-racial
responses for Non-Hispanics with primary race White or Black in the Non-Hispanic White or
Non-Hispanic Black categories. This means that there are slightly fewer people coded as nonHispanic white and non-Hispanic black through RIDRETH1 than for RIDRETH2; however,
this difference does not affect the Mexican American category.
The limit of detection (LOD) is the level at which the measurement has a 95% probability of
being greater than zero (Taylor 1987). For calculation of geometric means, concentrations less
than the LOD were assigned a value equal to the LOD divided by the square root of 2. If the
proportion of results less than the LOD (< LOD) was greater than 40%, geometric means were
not calculated. Percentile estimates less than the LOD were reported as < LOD. Most of the
indicators had very few results below the LOD value, so that the choice of statistical analysis to
handle these results makes little practical difference. There were a few exceptions, however (e.g.,
serum cis-beta-carotene, retinyl palmitate and retinyl stearate; urinary O-desmethylangolensin and
equol), where a larger proportion of results were < LOD. Appendix F contains a table of LOD
values for each biochemical indicator, as well as the unweighted percent of data values that were <
LOD for each survey cycle. LOD values may change over the time period of the report as a result
of changes in analytical methods. We used the higher of the two LOD values for the analysis of
the combined four-year data for 20032006.
Introduction
Due to changes to analytical methods for plasma total homocysteine, serum 25-hydroxyvitamin
D, and serum ferritin, an adjustment equation was applied to the data, as described in the
NHANES documentation:
http://www.cdc.gov/nchs/nhanes/nhanes1999-2000/LAB06.htm#Component_
Description
http://www.cdc.gov/nchs/nhanes/nhanes2003-2004/L06VID_C.htm
http://www.cdc.gov/nchs/nhanes/nhanes2003-2004/L06TFR_C.htm#Analytic_Notes.
For biochemical indicators measured in urine, we present separate tables for the concentration
of the indicator expressed as per volume of urine (uncorrected table) and the concentration of
the indicator expressed as per gram of creatinine (creatinine-corrected table). Comparison of
an individual participants result to population data in the tables requires correction for urinary
dilution; thus, an individual creatinine-corrected result is needed and should be compared
to the creatinine-corrected data tables. Otherwise, health scientists may compare means and
percentiles from other studies to the tables having either of the corresponding units. We used the
uncorrected tables to compare urine concentrations across groups. Because instrument responses
are measured in units of weight per volume, LOD calculations were performed by use of the
concentration of the indicator expressed as per volume of urine. For this reason, LOD results for
urine measurements in Appendix F are in weight per volume of urine. In the creatinine-corrected
tables, a result for a geometric mean or a percentile was reported as < LOD if the corresponding
geometric mean or percentile was < LOD in the uncorrected table. Thus, for example, if the
5th percentile for males was < LOD in the uncorrected table, it would also be < LOD in the
creatinine-corrected table.
References
Taylor JK. Quality assurance of chemical measurements. Chelsea (MI): Lewis Publishing; 1987.
U.S. Centers for Disease Control and Prevention. NHANES analytic guidelines, the Third National Health and
Nutrition Examination Survey, NHANES III (198894). Hyattsville (MD): National Center for Health Statistics;
October 1996 [cited 2011]. Available at: http://www.cdc.gov/nchs/data/nhanes/nhanes3/nh3gui.pdf.
Woodruff RS. Confidence intervals for medians and other position measures. J Am Stat Assoc.
1952;57:622627.
10
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
1. Water-Soluble Vitamins
B Vitamins and Related Biochemical Compounds
Folate (serum and red blood cell)
Vitamin B6
Pyridoxal-5-phosphate
4-Pyridoxic acid
Vitamin B12
Homocysteine
Methylmalonic acid
Vitamin C (Ascorbic Acid)
1. Water-Soluble Vitamins
13
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
absorption (e.g., Crohns disease, jejunal bypass surgery) can cause folate deficiency (Halsted
1990). Drugs that react with carbonyl groups have the potential to interact with PLP. Isoniazid
used in the treatment of tuberculosisand L-DOPA have been shown to reduce plasma PLP
concentrations, and a small decrease in vitamin B6 status has been seen in women taking highdose oral contraceptives (Institute of Medicine 1998). Most people who develop a vitamin
B12 deficiency have an underlying stomach or intestinal disorder that limits the absorption of
vitamin B12. Subtly reduced cognitive function resulting from early vitamin B12 deficiency is
sometimes the only symptom of these intestinal disorders. Severe vitamin B12 deficiency can
cause permanent nerve damage and dementia. Hematologic signs, however, are not always present
in vitamin B12 deficiency, and hematologic signs and neurologic abnormalities can be inversely
correlated (Baik 1999).
Clinical trials have shown that folic acid supplementation effectively reduces the number of neural
tube birth defects (NTDs) (Czeizel 1992; MRC Vitamin Study Research Group 1991). Thus,
the U.S. Public Health Service recommended that every woman who could become pregnant
consume at least 400 micrograms (g) of folic acid each day (U.S. Centers for Disease Control
and Prevention 1992). This recommendation has also been incorporated into the current Dietary
Guidelines for Americans, which list folate as a nutrient of concern for specific population groups
(U.S. Department of Agriculture 2010). Since 1998, the U.S. Food and Drug Administration
(FDA) has required the addition of folic acid to enriched breads, cereals, flours, corn meals,
pastas, rice, and other grain products (U.S. Food and Drug Administration 1996). After the
introduction of fortification, NTD rates have decreased by 36% (U.S. Centers for Disease
Control and Prevention 2010); nevertheless, in the era of folic acid fortification, NTD rates are
still highest among Hispanic women (Williams 2005). The higher prevalence in Hispanics could
be due to their lower consumption of total folic acid, which is specifically true for less acculturated
populations (Hamner 2011). This suggests that there may be factors in addition to folate status,
such as genetic or environmental factors, that modulate NTD prevalence and possibly lead to
higher folate requirements for some population groups. Recent observational studies have also
suggested other potential benefits of the U.S. folic acid fortification, such as decreased prevalence
of inadequate serum and RBC folate concentrations (Pfeiffer 2007), and declines in the
incidence of stroke (Yang 2006) and neuroblastoma (French 2003). Potential roles of B vitamins
in modulating the risk for diseases (e.g., heart disease, cancer, and cognitive impairment) are
currently being studied. Two national health objectives that relate to folate and maternal, infant,
and child health are part of the objectives for Healthy People 2020: Objective MICH HP2020-14
(increase the proportion of women of childbearing potential with intake of at least 400 g of folic
acid from fortified foods or dietary supplements) and Objective MICH HP2020-15 (reduce the
proportion of women of childbearing potential who have low red blood cell folate concentrations)
(http://www.healthypeople.gov/HP2020/).
Intake Recommendations. The recommended dietary allowance (RDA) for both men and
women is 400 g per day of dietary folate equivalents (DFEs). DFEs adjust for the nearly 50%
lower bioavailability of dietary folate compared to the bioavailability of folic acid: 1 mg of dietary
folate equivalent equals 0.6 mg of folic acid from fortified food or from a supplement taken on an
empty stomach (Institute of Medicine 1998). The RDA for vitamin B6 is 1.3 mg for both men and
women (1950 years), 1.7 mg for men and 1.5 mg for women aged 51 years and older, and 1.9
mg for pregnant women (2.0 mg if lactating) (Institute of Medicine 1998). The RDA for vitamin
B12 for adults is 2.4 g per day. Because as many as 10 to 30% of older people may be unable to
absorb naturally occurring vitamin B12, it is advisable for people older than 50 years to meet their
RDA mainly by consuming foods fortified with vitamin B12 or by taking a supplement containing
vitamin B12. People with vitamin B12 deficiency caused by a lack of intrinsic factor or intestinal
malabsorption require parenteral B12 treatment (Institute of Medicine 1998).
1. Water-Soluble Vitamins
15
Prolonged consumption of very high daily intakes of folic acid has the potential to delay the
diagnosis of anemia among adults with vitamin B12 deficiency. This may result in increased
risk of progressive, unrecognized neurological damage from untreated vitamin B12 deficiency.
Consequently, the Institute of Medicine (1998) set the Tolerable Upper Intake Level (UL) for
folic acid intake for adults (aged 19 years and older) at 1000 g per day. The UL is defined as
the maximum daily intake levels at which no risk of adverse health effects is expected for almost
all individuals in the general populationincluding sensitive individualswhen the nutrient is
consumed over long periods of time (Institute of Medicine 2000). Because no data were available
for children, the Institute of Medicine used the UL for adults adjusted by weight: 300800 mg
per day, depending on the age group. Folate intake from food
is not associated with any health risk. The UL for vitamin B6
for adults is 100 mg per day (Institute of Medicine 1998). If
more is ingested through supplements, sensory neuropathy,
dermatological lesions, and reversible nerve damage to the
arms and legs can occur. No adverse effects have been seen,
however, from getting large amounts of vitamin B6 through
food sources (Institute of Medicine 1998). No adverse effects
have been associated with excess vitamin B12 intake from food
or supplements in healthy individuals, and no UL has been set
(Institute of Medicine 1998).
Biochemical Indicators and Methods. Folate status can be
assessed by measuring serum or plasma folate, which provides
information on recent intake, and red blood cell (RBC) folate,
indicative of body folate stores and long-term nutritional status.
Vitamin B6 status is typically assessed by measuring the level of
one or more of the B6 vitamers in serum or plasma. Serum PLP
is generally viewed as the best single indicator of status. Serum
or urinary 4PA, the end product of vitamin B6 catabolism, is an
indicator of recent intake. Vitamin B12 status can be assessed by measuring serum or plasma total
cobalamins or serum holo-transcobalamin II, the transport protein of absorbed cobalamin. Urinary
or serum MMA is a specific functional indicator of vitamin B12 status. Plasma tHcy is a functional
indicator of folate, vitamin B6, and/or B12 status, but it is not specific for either vitamin. As B
vitamin concentrations decrease, plasma tHcy concentrations increase.
Clinical laboratories typically use conventional units for measuring concentrations of folate
(nanograms per milliliter [ng/mL]) and vitamin B12 (picograms [pg]/mL) and international
system (SI) units for vitamin B6 (nanomole per liter [nmol/L]), tHcy (micromole [mmol]/L), and
MMA (nmol/L). Conversion factors to SI units are as follows: 1 ng/mL = 2.266 nmol/L for folate
and 1 pg/mL = 0.738 picomol (pmol)/L for vitamin B12.
Traditionally, folate has been measured by microbiologic assay; however, in clinical settings,
radioprotein-binding assays or commercial non-radio-protein-binding assays on automated
clinical analyzers offering high throughput are used (Shane 2011). In research settings,
chromatography-based methods, nowadays coupled to tandem mass spectrometry (LC-MS/MS),
are often used to measure individual forms of folate in serum or whole blood (Pfeiffer 2010).
International reference materials for serum folate from the U.S. National Institute of Standards
and Technology (NIST) and the United Kingdom National Institute for Biological Standards and
Control (NIBSC), with certified or reference values by higher-order reference methods (LC-MS/
MS), have been available only for the last few years: NIST SRM 1955 and 1950, and NIBSC
03/178. A reference material for whole blood folate has been available from the NIBSC (95/528)
16
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
for several years; however, the value assignment for this material was by consensus of various
protein-binding and microbiological assays. Because of observed method differences in measuring
folate concentrations (Gunter 1996, Pfeiffer 2010), caution should be used in comparing other
datasets to the tables in this report. Method-specific cutoff values and reference intervals for use in
medical diagnostics have been suggested previously (Life Sciences Research Office 1994, Gunter
1996) and may be required until clinical assays have been standardized.
Vitamin B6 forms in serum are most commonly measured by high performance liquid
chromatography (HPLC) with fluorometric detection; chemical derivatization (sample, online,
or post-column) is almost always used to enhance PLP fluorescence (Rybak 2004). Enzymatic
(radioactive or nonradioactive) and microbiological methods have also been employed (Coburn
2000). LC-MS/MS methods are emerging (Midttun 2005). The comparability of methods could
be improved (Rybak 2005); such improvement is expected to occur in the future due to the new
availability of NIST SRM 1950 and 3950 (certified concentrations for serum PLP by LC-MS/MS).
Serum vitamin B12 is commonly measured by competitive protein-binding assay (Carmel 2011).
Research methods for tHcy determination are HPLC with fluorescence detection or coupled to
tandem mass spectrometry; clinical methods are based on immunoassay or enzymatic principle
(Refsum 2004). MMA is measured by gas chromatography coupled to mass spectrometry (GCMS) or by LC-MS/MS (Pedersen 2011). The comparability among methods for serum vitamin
B12, plasma Hcy, and MMA is superior to that for folate. The following international reference
materials are available: NIBSC 03/178 for serum vitamin B12 (consensus value); and NIST SRM
1955 and 1950 for plasma tHcy (certified concentration by LC-MS/MS or GC-MS).
Data in NHANES. Folate and vitamin B12 data presented in this report were generated by
use of the commercial BioRad Quantaphase II radio-protein-binding assay kit. This is the same
method used during the first four years of the continuous NHANES survey (1999-2002) and
during NHANES III (1988-1994) (Yetley 2011). The BioRad assay measures approximately
35% lower than the traditional microbiologic assay (Life Sciences Research Office 1994). As a
result, the conventional cutoff values of less than 3 ng/mL for low serum folate concentrations,
representing a negative folate balance at the time the blood sample was drawn, and less than
140 ng/mL for low RBC folate concentrations (Life Sciences Research Office 1984) should
be adjusted to less than 2 ng/mL and less than 95 ng/mL, respectively (Wright 1998). A 2005
WHO Technical Consultation on folate and vitamin B12 deficiencies estimated blood folate and
vitamin B12 concentrations below which plasma metabolite concentrations (tHcy for folate and
MMA for vitamin B12) became elevated. It arrived at the following consensus cutoff values: 4
ng/mL (10 nmol/L) for serum folate, 151 ng/mL (340 nmol/L) for RBC folate, and 203 pg/mL
(150 pmol/L) for serum vitamin B12 (de Benoist 2008). Because the folate data used to derive
these cutoff values were generated with the microbiologic assay, the cutoff values are not directly
applicable to data generated with the BioRad radio-protein-binding assay. For this report, we used
cutoff values of 2 ng/mL and 95 ng/mL, respectively, to estimate the prevalence of low serum and
RBC folate concentrations. To estimate the prevalence of low serum vitamin B12 concentrations,
we used a cutoff value of 200 pg/mL. This cutoff value is very close to the WHO consensus cutoff
value and has been widely used in previous studies (Carmel 2011).
Vitamin B6 data presented in this report include serum PLP and 4PA. They were generated by use
of HPLC with post-column derivatization and fluorometric detection (Rybak 2004; Rybak 2009).
We used a cutoff value of 20 nmol/L to indicate low serum PLP concentrations. This cutoff value
was used by the Institute of Medicine as the basis for the Estimated Average Requirement (EAR)
(1998); it may overestimate the vitamin B6 requirement for health maintenance of more than half
the group.
1. Water-Soluble Vitamins
17
Highlights
Blood concentrations of water-soluble B vitamins (folate, vitamins B6 and B12) in the U.S.
population showed the following demographic patterns and characteristics:
The highest concentrations were generally found in the youngest age group, except
for RBC folate and the vitamin B6 catabolite 4-pyridoxic acid where the highest
concentrations were found in the oldest age group.
No consistent pattern was observed with regard to gender.
A specific race/ethnic pattern was observed: non-Hispanic blacks had the lowest folate
and the highest vitamin B12 status, non-Hispanic whites had the highest folate and the
lowest vitamin B12 status, and Mexican Americans had intermediate folate and vitamin
B12 status.
In the era of folic acid fortification, the prevalence of folate deficiency was very low
throughout the population.
The likelihood of being vitamin B6 and B12 deficient was higher in persons 40 years
and older compared to younger persons.
18
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Monitoring the continued effect of the U.S. folic acid fortification program of enriched grains
and cereal products on serum and RBC folate concentrations is of great public health interest.
Serum folate concentrations more than doubled and RBC folate concentrations increased by
approximately 50% after the introduction of fortification in 1998. Regardless of gender or race/
ethnicity, we observed small decreases (< 10%) in serum and RBC folate concentrations from the
earlier (19992002) to the later (20032006) post-fortification period (Figures H.1.a and H.1.b).
However, during the first eight years post-fortification covered in this report (19992006), the
prevalence of low serum (< 2 ng/mL) and RBC folate (< 95 ng/mL) concentrations was less than
1% in the U.S. population, including women of childbearing age, regardless of race/ethnicity
(data not shown). Folate deficiency was virtually non-existent in the general population, and it
may be limited to persons with malabsorption, alcohol abusers, or consumers of certain drugs.
20
1988-1994
1999-2002
2003-2006
14
12
b
c
10
8
6
4
2
0
Total
population
Males
Females
Mexican
NonAmerican Hispanic
black
300
NonHispanic
white
16
1988-1994
350
18
b
c
1999-2002
2003-2006
b
b c
250
200
a
a
150
100
50
0
Total
population
Males
Females
Mexican
NonAmerican Hispanic
black
NonHispanic
white
Because of the close relationship of folate and vitamin B12 in one-carbon metabolism, it is of
interest to see whether serum vitamin B12 concentrations changed since the introduction of folic
acid fortification and whether there are differences among race/ethnic groups. We observed a small
increase in serum vitamin B12 concentrations from pre- (19911994) to post-fortification (1999
2002). We then found similar concentrations during 20032006 for the total population and for
males and females (Figure H.1.c). The increase from pre- to post-fortification was observed for
non-Hispanic whites, but not for non-Hispanic blacks and Mexican Americans; the latter two
groups had higher serum vitamin B12 concentrations than non-Hispanic whites during both preand post-fortification.
Assessing the extent of inadequate vitamin B12 status in the older U.S. population is challenging
because serum vitamin B12 is not sensitive enough, plasma tHcy is not specific, and both plasma
MMA and tHcy are artificially elevated when renal function is impaired, which is common in older
persons. As expected, we found a higher prevalence of elevated plasma MMA (17%) or tHcy (19%)
concentrations, potentially indicating suboptimal vitamin B12 status, than we found in the prevalence
of low serum vitamin B12 concentrations (4%) in older persons (Figure H.1.d). Defining better
cutoff values for vitamin B12 status biomarkers remains a continued area of research (Bailey 2011).
1. Water-Soluble Vitamins
19
600
500
b b
b b
1999-2002
b
a b
a a a
25
2003-2006
a a a
20
a
b b
400
300
200
15
10
5
100
0
Prevalence (%)
1991-1994
Total
population
Males
Females
Mexican
NonAmerican Hispanic
black
NonHispanic
white
Serum B12
< 200 pg/mL
Plasma MMA
> 271 nmol/L
Plasma tHcy
> 13 mol/L
Error bars represent 95% confidence intervals. Within a demographic group, bars
not sharing a common letter differ (p < 0.05). Age adjustment was done using
direct standardization.
Data shown for plasma MMA are from NHANES 20032004 only. Error bars
represent 95% confidence intervals.
Detailed Observations
The selected observations mentioned below are derived from the tables and figures presented next.
Statements about categorical differences between demographic groups noted below are based on
non-overlapping confidence limits from univariate analysis without adjusting for demographic
variables (e.g., age, gender, race/ethnicity) or other blood concentration determinants (e.g., dietary
intake, supplement usage, smoking, BMI). A multivariate analysis may alter the size and statistical
significance of these categorical differences. Furthermore, additional significant differences of
smaller magnitude may be present despite their lack of mention here (e.g., if confidence limits
slightly overlap or if differences are not statistically significant before covariate adjustment has
occurred). For a selection of citations of descriptive NHANES papers related to these biochemical
indicators of diet and nutrition, see Appendix G.
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
vitamin B12 (Table 1.5.a.1) and plasma MMA (Table 1.7.a.1) concentrations.
Non-Hispanic whites had the highest concentrations of serum and RBC folate (Tables
1.1.a.1 and 1.2.a.1), serum 4PA (Table 1.4.a.1), and plasma MMA (Table 1.7.a.1).
They also had the lowest concentrations of serum vitamin B12 (Table 1.5.a.1). NonHispanic blacks had the lowest concentrations of RBC folate (Table 1.2.a.1) and serum
PLP (Table 1.3.a.1). Mexican Americans had the lowest concentrations of plasma tHcy
(Table 1.6.a.1).
1. Water-Soluble Vitamins
21
22
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
11.1
10.4
13.0
11.7
12.9
16.2
16.1
11.2
10.4
11.6
15.6
12.3
(10.7 11.4)
(10.1 10.7)
(12.5 13.4)
(11.4 12.0)
(12.5 13.3)
(15.5 16.9)
(15.6 16.6)
(11.0 11.5)
(10.1 10.7)
(11.2 12.0)
(15.0 16.1)
(12.0 12.6)
Geometric mean
4.67
4.19
4.58
4.39
4.56
6.29
8.21
4.86
4.24
4.23
5.31
4.51
(4.52 4.92)
(4.01 4.36)
(4.40 4.81)
(4.29 4.60)
(4.41 4.81)
(5.51 6.93)
(7.82 8.58)
(4.57 5.11)
(4.08 4.46)
(3.70 4.40)
(4.83 5.57)
(4.36 4.61)
2.5th
5.49
4.83
5.72
5.32
5.61
7.61
9.04
5.62
4.93
5.09
6.32
5.46
(5.17 5.68)
(4.56 5.07)
(5.36 5.98)
(5.00 5.55)
(5.33 5.91)
(6.92 8.24)
(8.63 9.58)
(5.45 5.83)
(4.75 5.09)
(4.57 5.42)
(5.95 6.61)
(5.26 5.66)
11.1
10.3
12.9
11.6
12.9
16.0
15.7
11.3
10.5
11.6
15.8
12.2
(10.8 11.4)
(9.94 10.8)
(12.5 13.3)
(11.3 11.9)
(12.5 13.2)
(15.5 16.5)
(15.3 16.2)
(10.9 11.6)
(10.1 10.9)
(11.3 11.9)
(15.2 16.3)
(11.9 12.5)
22.2
22.6
30.1
26.4
29.7
36.0
29.9
20.9
20.5
25.2
35.7
28.5
(20.8 23.4)
(21.4 23.5)
(29.2 31.5)
(25.6 27.8)
(28.8 31.2)
(32.0 41.9)
(27.5 35.0)
(19.9 21.8)
(19.5 22.9)
(24.1 28.1)
(34.2 37.7)
(27.5 29.5)
25.9
27.0
36.0
32.2
35.6
50.8
35.9
24.6
26.1
32.8
45.7
34.0
(24.3 28.8)
(25.6 29.3)
(34.2 38.5)
(30.6 34.8)
(33.6 37.8)
(37.7 77.7)
(32.3 46.3)
(23.4 25.8)
(23.1 29.9)
(29.2 37.1)
(42.1 49.6)
(32.5 36.0)
97.5th
Geometric mean and selected percentiles of serum concentrations (in ng/mL) for the total U.S. population aged 1 year and older,
National Health and Nutrition Examination Survey, 20032006.
4,212
4,297
6,633
8,050
8,361
1,690
1,749
4,028
3,242
2,649
3,053
16,411
Sample
size
10
15
Females
Males
Serum folate
(ng/mL)
20
Overall
15
611
1219
2039
4059
60+
15
611
2039
4059
60+
4059
60+
NonHispanic Whites
15
10
5
0
Serum folate
(ng/mL)
20
NonHispanic Blacks
1219
15
611
1219
2039
4059
60+
15
611
2039
Males
10
15
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum folate
(ng/mL)
20
Females
1219
15
611
1219
2039
Age (years)
4059
60+
15
611
1219
2039
4059
60+
Age (years)
1. Water-Soluble Vitamins
23
12.3
16.2
16.1
11.2
10.4
11.6
15.6
(12.0 12.6)
(15.5 16.9)
(15.6 16.6)
(11.0 11.5)
(10.1 10.7)
(11.2 12.0)
(15.0 16.1)
5.46
7.61
9.04
5.62
4.93
5.09
6.32
(5.26 5.66)
(6.92 8.24)
(8.63 9.58)
(5.45 5.83)
(4.75 5.09)
(4.57 5.42)
(5.95 6.61)
12.2
16.0
15.7
11.3
10.5
11.6
15.8
(11.9 12.5)
(15.5 16.5)
(15.3 16.2)
(10.9 11.6)
(10.1 10.9)
(11.3 11.9)
(15.2 16.3)
28.5
36.0
29.9
20.9
20.5
25.2
35.7
(27.5 29.5)
(32.0 41.9)
(27.5 35.0)
(19.9 21.8)
(19.5 22.9)
(24.1 28.1)
(34.2 37.7)
16,411
1,690
1,749
4,028
3,242
2,649
3,053
11.7
16.2
15.8
11.2
9.83
10.8
14.7
(11.4 12.0)
(15.3 17.1)
(15.2 16.4)
(10.9 11.5)
(9.51 10.2)
(10.4 11.3)
(14.0 15.6)
5.32
7.56
9.10
5.45
4.84
4.84
6.12
(5.00 5.55)
(6.40 8.53)
(8.37 9.77)
(4.94 5.82)
(4.66 5.03)
(4.39 5.26)
(5.81 6.42)
11.6
15.8
15.3
11.3
9.89
11.0
14.7
(11.3 11.9)
(15.2 16.3)
(14.8 16.0)
(10.9 11.6)
(9.53 10.3)
(10.4 11.4)
(13.7 15.7)
26.4
36.2
29.1
20.5
18.3
22.7
34.9
(25.6 27.8)
(32.0 46.5)
(26.2 34.9)
(19.8 21.9)
(17.6 20.0)
(20.5 25.8)
(32.5 41.9)
8,050
854
854
2,041
1,462
1,305
1,534
12.9
16.3
16.5
11.3
11.0
12.3
16.2
(12.5 13.3)
(15.6 17.0)
(15.8 17.2)
(10.9 11.7)
(10.6 11.5)
(11.9 12.8)
(15.7 16.8)
5.61
7.65
9.01
5.76
5.05
5.37
6.57
(5.33 5.91)
(6.80 8.30)
(8.62 9.59)
(5.57 6.04)
(4.63 5.27)
(4.56 5.96)
(6.05 6.92)
12.9
16.3
16.2
11.2
11.1
12.4
16.5
(12.5 13.2)
(15.8 17.0)
(15.5 16.9)
(10.9 11.7)
(10.7 11.6)
(11.9 12.9)
(15.9 17.2)
29.7
34.6
30.8
21.3
23.1
27.6
36.1
(28.8 31.2)
(30.2 46.5)
(28.2 36.6)
(19.6 23.4)
(21.1 26.1)
(25.2 32.1)
(34.4 38.5)
8,361
836
895
1,987
1,780
1,344
1,519
Males
Females
11.1
14.1
15.4
10.9
9.60
10.4
12.4
(10.7 11.4)
(13.4 14.7)
(14.7 16.2)
(10.6 11.2)
(9.24 9.96)
(9.76 11.1)
(11.6 13.2)
5.49
7.56
9.03
5.89
5.04
5.13
5.36
(5.17 5.68)
(6.85 8.17)
(8.32 9.67)
(5.43 6.28)
(4.70 5.19)
(4.59 5.67)
(4.61 6.41)
11.1
14.0
15.2
11.1
9.62
10.1
12.1
(10.8 11.4)
(13.3 14.8)
(14.2 16.0)
(10.8 11.5)
(9.07 10.2)
(9.51 11.0)
(11.6 12.6)
22.2
26.2
28.2
19.1
18.1
21.0
27.1
(20.8 23.4)
(23.8 29.4)
(26.2 32.2)
(18.2 19.8)
(16.8 19.6)
(18.7 23.7)
(24.6 37.1)
4,212
542
586
1,281
781
469
553
10.6
13.7
15.1
10.9
9.11
10.1
11.4
(10.3 11.0)
(13.1 14.5)
(14.3 16.0)
(10.5 11.3)
(8.67 9.57)
(9.43 10.8)
(10.7 12.1)
5.35
8.03
8.68
5.62
4.90
5.11
5.27
(4.99 5.65)
(6.22 8.33)
(7.46 9.86)
(4.99 5.94)
(4.47 5.37)
(4.48 5.91)
(4.61 6.23)
10.7
13.5
14.9
11.1
9.09
10.0
10.5
(10.3 11.0)
(12.7 14.5)
(13.7 16.0)
(10.6 11.4)
(8.68 9.70)
(9.19 10.7)
(9.85 12.1)
20.2
23.9
28.3
19.1
15.6
19.1
26.0
(19.5 22.4)
(21.2 31.4)
(25.4 32.3)
(17.7 20.6)
(14.7 18.7)
(18.1 22.5)
(22.9 36.9)
2,042
263
285
638
347
237
272
11.5
14.4
15.7
11.0
10.2
10.7
13.3
(11.1 12.0)
(13.6 15.2)
(14.9 16.5)
(10.7 11.3)
(9.62 10.8)
(10.0 11.5)
(12.0 14.7)
5.64
7.34
9.13
6.23
5.11
5.16
5.62
(5.15 5.87)
(6.41 8.10)
(8.01 10.2)
(5.78 6.54)
(4.74 5.38)
(3.80 5.85)
(4.00 6.65)
11.6
14.4
15.5
11.2
10.4
10.4
13.0
(11.3 11.8)
(13.7 15.9)
(14.8 16.3)
(10.8 11.6)
(9.53 11.0)
(9.57 11.4)
(12.1 13.7)
23.3
26.5
27.8
19.0
19.3
22.4
29.7
(21.8 25.6)
(24.5 31.9)
(25.9 34.2)
(18.2 21.0)
(18.1 21.8)
(19.1 40.0)
(25.3 64.8)
2,170
279
301
643
434
232
281
Males
Females
24
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
10.4
15.0
14.8
9.98
8.92
9.81
11.5
(10.1 10.7)
(14.0 16.0)
(14.2 15.3)
(9.63 10.4)
(8.56 9.29)
(9.28 10.4)
(10.8 12.3)
4.83
7.08
8.62
5.19
4.56
4.34
4.88
(4.56 5.07)
(5.99 7.80)
(7.91 9.03)
(4.98 5.39)
(4.26 4.81)
(3.93 4.99)
(4.48 5.29)
10.3
14.9
14.6
9.91
8.73
9.75
11.3
(9.94 10.8)
(14.3 15.6)
(14.0 15.2)
(9.59 10.3)
(8.34 9.23)
(9.04 10.3)
(10.7 11.9)
22.6
32.9
25.3
18.3
17.7
20.0
27.2
(21.4 23.5)
(28.0 40.7)
(23.9 29.4)
(17.7 19.1)
(16.7 19.1)
(18.8 26.0)
(24.5 36.0)
4,297
481
554
1,417
711
621
513
10.1
14.9
14.4
10.2
8.48
9.41
11.1
(9.84 10.4)
(13.7 16.2)
(13.8 15.1)
(9.85 10.6)
(8.07 8.91)
(8.82 10.0)
(10.4 11.8)
4.67
6.69
8.87
5.02
4.33
4.11
4.73
(4.34 4.94)
(5.91 7.81)
(8.20 9.55)
(4.75 5.19)
(4.01 4.81)
(3.42 4.99)
(3.87 5.82)
10.1
14.7
14.3
10.3
8.35
9.38
10.7
(9.76 10.5)
(13.9 15.5)
(13.6 14.9)
(9.82 10.8)
(7.82 8.89)
(8.49 10.1)
(9.77 11.3)
21.1
36.5
24.3
19.0
15.4
18.7
29.0
(19.7 23.2)
(29.0 51.9)
(21.2 30.8)
(17.9 19.8)
(14.5 17.7)
(17.3 32.9)
(23.9 32.7)
2,141
238
273
742
339
291
258
10.6
15.1
15.1
9.76
9.30
10.2
11.8
(10.2 11.0)
(14.0 16.4)
(14.1 16.1)
(9.35 10.2)
(8.78 9.86)
(9.56 10.8)
(10.8 12.9)
5.00
7.33
8.03
5.42
4.68
4.48
4.95
(4.62 5.23)
(5.00 8.42)
(7.24 8.98)
(4.98 5.57)
(4.44 5.01)
(4.07 5.18)
(4.26 5.65)
10.5
15.1
14.9
9.67
9.00
10.1
11.6
(10.0 11.1)
(14.2 16.3)
(14.0 15.9)
(9.21 10.0)
(8.52 9.59)
(9.24 10.7)
(11.0 12.8)
23.3
28.8
26.0
17.7
19.1
22.1
26.8
(22.0 24.9)
(26.7 40.8)
(24.3 33.6)
(16.9 18.4)
(17.8 20.8)
(19.2 27.7)
(23.9 45.8)
2,156
243
281
675
372
330
255
Males
Females
13.0
17.4
16.8
11.7
11.0
12.0
16.3
(12.5 13.4)
(16.2 18.6)
(16.1 17.5)
(11.3 12.1)
(10.6 11.5)
(11.5 12.6)
(15.7 17.0)
5.72
7.94
9.54
5.83
5.22
5.14
6.55
(5.36 5.98)
(6.77 8.99)
(8.59 10.0)
(5.57 6.19)
(4.82 5.54)
(4.55 5.61)
(6.19 6.92)
12.9
17.0
16.5
11.6
11.1
12.1
16.7
(12.5 13.3)
(16.0 17.8)
(15.9 17.2)
(11.3 12.2)
(10.7 11.5)
(11.7 12.6)
(16.1 17.2)
30.1
37.9
31.7
22.1
22.9
26.1
36.8
(29.2 31.5)
(34.7 56.0)
(28.0 37.6)
(21.2 23.4)
(20.6 26.2)
(24.3 31.7)
(34.9 39.4)
6,633
478
449
1,048
1,453
1,357
1,848
12.3
17.3
16.4
11.6
10.4
11.2
15.5
(11.8 12.7)
(16.0 18.8)
(15.5 17.5)
(11.2 12.0)
(9.94 10.9)
(10.6 11.9)
(14.5 16.5)
5.56
8.02
8.91
5.58
5.30
4.95
6.35
(5.04 5.93)
(5.84 9.82)
(7.81 10.0)
(4.93 6.17)
(4.75 5.82)
(4.36 5.35)
(5.91 6.72)
12.1
16.5
16.2
11.6
10.5
11.5
15.6
(11.7 12.6)
(15.7 17.9)
(15.1 16.9)
(11.2 12.1)
(9.93 11.0)
(10.9 12.1)
(14.5 16.6)
28.0
36.3
30.4
21.8
19.5
22.9
37.0
(26.4 29.8)
(32.6 55.8)
(26.1 52.6)
(20.4 23.3)
(18.1 22.9)
(20.9 26.8)
(32.7 45.3)
3,268
259
216
528
638
689
938
13.7
17.4
17.2
11.8
11.7
12.9
17.1
(13.2 14.1)
(16.0 18.9)
(16.4 18.1)
(11.3 12.4)
(11.1 12.4)
(12.3 13.5)
(16.5 17.7)
5.88
7.79
9.71
5.90
5.19
5.40
6.85
(5.45 6.20)
(6.32 8.79)
(8.72 10.2)
(5.64 6.67)
(4.54 5.60)
(4.54 6.22)
(6.21 7.22)
13.7
17.1
17.0
11.8
11.8
13.1
17.6
(13.2 14.2)
(15.9 18.0)
(15.9 17.7)
(11.1 12.5)
(11.1 12.5)
(12.3 13.7)
(16.8 18.4)
31.6
42.7
31.7
22.2
25.7
30.9
36.6
(30.3 32.9)
(30.9 73.2)
(28.3 38.2)
(20.5 25.1)
(22.8 30.7)
(25.5 34.0)
(34.9 39.7)
3,365
219
233
520
815
668
910
Males
Females
1. Water-Soluble Vitamins
25
14.0
12.9
12.1
12.4
(13.4 14.8)
(12.5 13.3)
(11.7 12.6)
(11.9 12.9)
5.74
5.73
5.40
5.47
(5.35 6.10)
(5.36 6.05)
(5.12 5.69)
(5.10 5.80)
14.2
13.0
11.9
12.3
(13.4 15.0)
(12.7 13.4)
(11.5 12.4)
(11.9 12.7)
33.1
27.2
28.2
28.5
(31.6 34.9)
(26.4 28.5)
(27.1 29.7)
(26.5 30.2)
7,526
8,386
7,836
7,774
19992000
20012002
20032004
20052006
20.1
17.3
16.6
17.6
(18.8 21.4)
(16.3 18.4)
(15.1 18.2)
(16.5 18.8)
10.5
9.44
8.59
9.56
(7.89 12.2)
(7.08 10.6)
(5.22 9.61)
(8.34 10.3)
19.1
17.1
16.2
16.7
(17.9 21.6)
(16.1 18.3)
(15.2 17.0)
(16.1 17.9)
38.2
31.9
34.5
37.6
(34.0 45.1)
(29.5 38.5)
(29.4 57.9)
(31.3 77.2)
361
438
448
441
19992000
20012002
20032004
20052006
19.3
17.2
15.6
16.7
(18.4 20.3)
(16.6 17.9)
(14.9 16.3)
(15.9 17.5)
11.0
9.31
9.39
8.77
(10.6 11.4)
(8.75 9.78)
(8.66 9.85)
(8.26 9.60)
19.3
17.1
15.2
16.3
(18.4 19.9)
(16.3 17.8)
(14.7 16.0)
(15.5 17.1)
33.4
32.7
27.4
32.4
(31.6 36.3)
(29.9 37.9)
(24.4 34.0)
(29.5 36.9)
885
1,023
843
906
19992000
20012002
20032004
20052006
13.3
12.2
11.0
11.5
(12.6 14.0)
(11.6 12.8)
(10.5 11.5)
(11.2 11.8)
6.26
5.91
5.56
5.65
(5.72 6.61)
(5.29 6.28)
(5.20 6.02)
(5.39 5.90)
13.3
12.5
11.0
11.6
(12.7 14.0)
(11.9 13.3)
(10.5 11.4)
(11.1 12.1)
27.6
22.1
19.7
21.8
(25.6 31.3)
(21.2 23.4)
(19.1 22.1)
(21.1 22.6)
2,124
2,208
2,058
1,970
19992000
20012002
20032004
20052006
11.8
11.1
10.2
10.6
(11.0 12.7)
(10.6 11.6)
(9.78 10.6)
(10.2 11.1)
5.15
5.27
4.83
5.07
(4.40 5.55)
(4.78 5.59)
(4.62 5.01)
(4.76 5.33)
11.6
11.1
10.2
10.8
(10.6 12.8)
(10.6 11.6)
(9.59 10.8)
(10.3 11.2)
28.6
22.6
20.0
21.1
(25.6 30.8)
(20.6 24.3)
(19.1 22.9)
(19.2 25.9)
1,470
1,714
1,555
1,687
19992000
20012002
20032004
20052006
13.6
12.2
11.6
11.6
(12.7 14.5)
(11.7 12.7)
(11.0 12.3)
(11.0 12.2)
5.37
5.63
5.20
4.85
(4.37 6.08)
(4.86 6.06)
(4.57 5.60)
(4.39 5.57)
13.6
12.5
11.6
11.7
(12.7 14.7)
(11.9 13.1)
(11.1 11.9)
(11.1 12.1)
31.6
24.0
26.0
24.4
(30.0 35.4)
(22.4 25.3)
(23.8 32.8)
(22.8 29.0)
1,199
1,475
1,276
1,373
19992000
20012002
20032004
20052006
17.4
16.1
15.7
15.4
(16.7 18.1)
(15.4 16.8)
(15.1 16.4)
(14.5 16.4)
7.09
6.50
6.53
6.06
(6.48 7.51)
(5.75 7.09)
(6.13 7.00)
(5.40 6.58)
17.4
16.6
15.6
15.8
(16.5 18.2)
(15.4 17.5)
(14.8 16.4)
(15.0 16.8)
42.3
37.3
34.9
36.4
(39.2 44.8)
(34.2 40.7)
(32.9 37.7)
(34.4 41.9)
1,487
1,528
1,656
1,397
19992000
20012002
20032004
20052006
13.3
12.3
11.6
11.7
(12.7 14.0)
(11.8 12.8)
(11.1 12.1)
(11.2 12.1)
5.53
5.64
5.31
5.24
(4.73 6.13)
(5.17 6.00)
(4.93 5.69)
(4.74 5.59)
13.4
12.5
11.5
11.6
(12.7 14.2)
(12.1 13.0)
(11.1 11.9)
(11.2 12.0)
30.6
25.0
26.2
26.2
(29.0 32.2)
(23.7 27.0)
(24.7 28.1)
(25.2 28.5)
3,684
4,063
3,871
3,780
19992000
20012002
20032004
20052006
14.8
13.5
12.6
13.1
(14.0 15.6)
(13.1 13.9)
(12.1 13.1)
(12.5 13.7)
5.94
5.80
5.51
5.66
(5.60 6.18)
(5.39 6.35)
(5.12 5.84)
(5.25 6.14)
14.8
13.6
12.5
13.2
(14.1 16.0)
(13.2 14.0)
(12.0 13.0)
(12.6 13.8)
35.3
29.3
29.5
29.9
(33.7 37.5)
(27.3 31.6)
(28.3 31.6)
(28.2 32.2)
3,842
4,323
3,965
3,994
19992000
20012002
20032004
20052006
13.2
11.6
10.9
11.1
(12.8 13.7)
(10.9 12.4)
(10.4 11.5)
(10.7 11.5)
6.10
5.48
5.20
5.56
(5.49 6.51)
(4.66 6.08)
(5.09 5.50)
(5.18 5.79)
13.5
11.8
11.1
11.0
(12.9 14.0)
(11.1 12.5)
(10.7 11.6)
(10.6 11.5)
28.4
22.5
20.9
23.1
(27.1 30.2)
(20.0 26.1)
(19.2 23.4)
(21.6 25.0)
2,571
2,124
1,919
2,012
19992000
20012002
20032004
20052006
11.7
10.9
10.1
10.6
(11.1 12.4)
(10.2 11.6)
(9.66 10.6)
(10.1 11.1)
5.15
5.06
4.65
4.95
(4.67 5.42)
(4.47 5.39)
(4.28 5.11)
(4.68 5.15)
11.6
10.7
10.1
10.5
(10.9 12.4)
(10.1 11.4)
(9.37 10.8)
(9.92 11.2)
27.3
23.6
21.9
22.9
(24.9 31.5)
(21.7 25.2)
(19.9 23.7)
(21.4 24.0)
1,712
2,004
2,057
2,040
19992000
20012002
20032004
20052006
14.8
13.4
12.9
13.0
(13.8 15.8)
(13.0 13.9)
(12.2 13.5)
(12.4 13.6)
6.11
5.90
5.76
5.62
(5.52 6.55)
(5.62 6.21)
(5.31 6.08)
(4.96 6.04)
15.0
13.6
12.7
12.9
(13.9 16.2)
(13.2 14.1)
(12.1 13.3)
(12.4 13.5)
34.2
28.4
30.0
29.9
(32.6 36.0)
(27.2 29.9)
(28.5 32.1)
(28.3 32.2)
2,557
3,590
3,272
3,120
Age group
3-5 years
611 years
1219 years
2039 years
4059 years
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
26
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
60
40
1
1
1
1
1
1
1
1
1
20
1
1
1
1
1
1
1
1
0
25
50th Percentile
20
1
1
15
1
1
1
1
1
1
1
1
1
10
1
1
1
1
1
1
1
5
14
1
1
10
1
1
8
6
1
1
1
1
1
1
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
4
9900
0102
0304
0506
5th Percentile
12
Total
(3+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
1. Water-Soluble Vitamins
27
28
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
247
214
281
259
272
272
263
229
244
270
324
265
(242 252)
(210 218)
(274 288)
(253 264)
(267 277)
(265 279)
(258 268)
(225 234)
(238 250)
(264 276)
(317 332)
(261 270)
Geometric mean
133
112
144
133
132
152
164
126
126
132
147
133
(125 138)
(107 116)
(137 149)
(128 138)
(127 136)
(149 160)
(152 171)
(123 130)
(119 131)
(126 137)
(140 151)
(129 136)
2.5th
149
125
160
149
149
174
180
140
140
149
161
149
(138 155)
(120 130)
(154 165)
(144 153)
(146 153)
(169 178)
(172 184)
(134 146)
(136 144)
(143 154)
(157 166)
(146 152)
5th
241
213
276
255
268
266
259
229
241
273
327
261
(237 246)
(210 216)
(269 282)
(250 259)
(262 273)
(261 272)
(254 264)
(224 233)
(235 247)
(266 279)
(315 338)
(256 265)
50th
452
382
529
469
522
483
430
370
449
481
656
501
(434 465)
(367 398)
(510 537)
(453 489)
(508 535)
(436 531)
(400 456)
(355 390)
(421 480)
(461 510)
(622 705)
(487 515)
95th
529
428
617
551
604
560
470
436
512
554
768
(506 558)
(419 449)
(594 653)
(529 588)
(576 642)
(521 668)
(457 511)
(398 471)
(483 547)
(519 605)
(724 860)
(566 604)
97.5th
581
4,304
4,404
6,675
8,172
8,498
1,861
1,779
4,050
3,262
2,649
3,069
16,670
Sample
size
Geometric mean and selected percentiles of red blood cell concentrations (in ng/mL) for the total U.S. population aged 1 year and older,
National Health and Nutrition Examination Survey, 20032006.
100
200
300
Females
Males
400
Overall
15
611
2039
4059
60+
15
611
2039
4059
60+
4059
60+
NonHispanic Whites
100
200
300
400
NonHispanic Blacks
1219
1219
15
611
2039
4059
60+
15
611
400
Females
1219
2039
Males
100
200
300
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
1219
15
611
1219
2039
Age (years)
4059
60+
15
611
1219
2039
4059
60+
Age (years)
1. Water-Soluble Vitamins
29
Geometric mean
5th
50th
95th
Sample
size
265
272
263
229
244
270
324
(261 270)
(265 279)
(258 268)
(225 234)
(238 250)
(264 276)
(317 332)
149
174
180
140
140
149
161
(146 152)
(169 178)
(172 184)
(134 146)
(136 144)
(143 154)
(157 166)
261
266
259
229
241
273
327
(256 265)
(261 272)
(254 264)
(224 233)
(235 247)
(266 279)
(315 338)
501
483
430
370
449
481
656
(487 515)
(436 531)
(400 456)
(355 390)
(421 480)
(461 510)
(622 705)
16,670
1,861
1,779
4,050
3,262
2,649
3,069
259
281
265
229
235
263
313
(253 264)
(271 290)
(259 271)
(225 234)
(228 242)
(256 271)
(302 324)
149
176
182
142
140
149
159
(144 153)
(170 185)
(173 188)
(135 148)
(131 148)
(140 154)
(154 163)
255
271
257
229
235
265
311
(250 259)
(264 281)
(251 264)
(223 233)
(226 244)
(256 275)
(297 328)
469
507
439
361
397
463
651
(453 489)
(460 560)
(414 468)
(353 385)
(379 429)
(431 513)
(595 709)
8,172
941
867
2,051
1,467
1,309
1,537
272
263
261
229
253
276
334
(267 277)
(255 270)
(254 269)
(223 234)
(246 261)
(269 284)
(324 344)
149
173
176
138
139
149
162
(146 153)
(161 177)
(162 183)
(130 146)
(134 145)
(139 157)
(157 172)
268
262
260
229
248
278
338
(262 273)
(254 267)
(253 267)
(223 234)
(239 258)
(271 288)
(325 352)
522
436
402
373
486
501
661
(508 535)
(395 531)
(379 459)
(354 398)
(461 529)
(467 536)
(616 744)
8,498
920
912
1,999
1,795
1,340
1,532
Males
Females
Geometric mean
5th
95th
247
266
259
231
237
254
277
(242 252)
(257 275)
(252 266)
(225 237)
(228 246)
(245 264)
(263 292)
149
170
170
144
139
149
147
(138 155)
(152 177)
(156 183)
(136 154)
(125 154)
(132 157)
(130 156)
241
258
256
225
232
249
271
(237 246)
(249 266)
(249 262)
(221 232)
(223 241)
(235 264)
(258 290)
452
477
443
402
437
451
565
(434 465)
(441 507)
(396 483)
(386 423)
(402 463)
(415 520)
(483 646)
4,304
610
595
1,288
787
471
553
238
276
263
226
221
245
257
(231 245)
(263 289)
(253 274)
(219 233)
(211 231)
(235 255)
(243 271)
146
171
171
139
136
149
146
(133 153)
(151 189)
(151 189)
(134 147)
(106 153)
(122 158)
(121 150)
234
267
258
223
220
234
248
(230 239)
(260 275)
(249 265)
(214 230)
(211 231)
(226 250)
(234 268)
413
481
466
378
367
429
478
(388 445)
(445 553)
(422 523)
(340 455)
(333 406)
(373 538)
(438 542)
2,087
298
289
639
350
238
273
257
255
254
237
256
264
295
(252 263)
(245 265)
(245 263)
(230 243)
(247 267)
(249 281)
(269 322)
154
165
170
153
149
144
148
(140 161)
(139 177)
(153 180)
(135 158)
(135 161)
(110 159)
(91.6 168)
250
248
253
230
250
263
306
(246 256)
(240 258)
(246 261)
(224 237)
(236 267)
(244 287)
(267 329)
477
445
405
420
490
486
587
(460 505)
(398 506)
(358 477)
(398 450)
(458 587)
(424 746)
(550 682)
2,217
312
306
649
437
233
280
Males
Females
30
50th
Sample
size
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
5th
50th
95th
Sample
size
214
225
230
194
204
216
242
(210 218)
(218 232)
(225 235)
(190 199)
(199 210)
(208 225)
(231 254)
125
143
156
118
119
124
131
(120 130)
(132 152)
(146 165)
(111 124)
(115 122)
(107 132)
(125 137)
213
226
231
195
203
215
237
(210 216)
(221 231)
(224 238)
(191 200)
(193 209)
(209 221)
(221 252)
382
350
336
312
370
386
449
(367 398)
(330 371)
(321 370)
(299 319)
(350 406)
(359 436)
(423 508)
4,404
525
572
1,432
717
630
528
209
228
231
195
195
211
233
(205 213)
(219 238)
(225 237)
(190 201)
(188 201)
(202 220)
(222 245)
122
143
164
123
116
120
128
(119 129)
(122 152)
(146 170)
(110 131)
(113 121)
(95.7 133)
(123 134)
208
227
231
198
192
209
224
(204 213)
(220 235)
(222 239)
(190 204)
(184 204)
(201 218)
(211 240)
355
359
337
305
309
375
461
(344 375)
(333 418)
(319 386)
(289 320)
(298 337)
(355 435)
(413 541)
2,189
259
282
750
339
295
264
219
221
230
193
213
221
248
(214 224)
(214 228)
(221 239)
(188 200)
(204 221)
(210 233)
(232 267)
127
146
149
113
121
128
135
(119 131)
(124 158)
(142 161)
(109 119)
(108 132)
(99.8 133)
(104 150)
216
224
230
194
210
219
245
(212 221)
(218 232)
(219 242)
(190 200)
(199 219)
(211 232)
(220 275)
397
334
334
314
406
389
445
(374 416)
(301 361)
(314 388)
(299 341)
(371 428)
(353 494)
(421 521)
2,215
266
290
682
378
335
264
Males
Females
Geometric mean
5th
50th
95th
Sample
size
281
290
274
239
258
281
339
(274 288)
(277 304)
(267 281)
(233 246)
(250 267)
(273 290)
(330 348)
160
191
191
152
152
159
173
(154 165)
(179 201)
(187 197)
(145 158)
(143 159)
(150 165)
(162 183)
276
278
268
238
254
285
340
(269 282)
(267 293)
(261 275)
(231 246)
(246 262)
(275 293)
(328 350)
529
528
439
376
464
494
673
(510 537)
(484 598)
(411 464)
(356 407)
(435 504)
(466 532)
(645 732)
6,675
523
454
1,046
1,460
1,346
1,846
274
299
277
241
250
275
326
(267 281)
(284 316)
(268 286)
(234 248)
(240 260)
(265 286)
(314 338)
161
200
193
152
154
160
170
(153 167)
(173 208)
(188 202)
(139 158)
(141 165)
(148 165)
(161 184)
269
283
269
238
248
280
322
(262 278)
(268 312)
(258 278)
(231 249)
(238 258)
(266 292)
(306 340)
493
537
447
374
414
474
660
(473 524)
(498 659)
(425 517)
(355 437)
(395 447)
(433 534)
(609 716)
3,294
286
218
527
641
688
934
288
280
270
238
267
287
350
(280 296)
(264 296)
(261 280)
(231 245)
(257 278)
(277 298)
(337 362)
158
183
188
149
149
158
177
(153 164)
(152 196)
(170 198)
(136 160)
(139 155)
(148 167)
(158 186)
282
272
267
237
263
289
352
(273 290)
(263 286)
(259 276)
(230 244)
(251 272)
(276 302)
(338 370)
546
486
390
381
502
506
689
(531 569)
(428 584)
(373 456)
(350 447)
(473 557)
(477 545)
(630 796)
3,381
237
236
519
819
658
912
Males
Females
1. Water-Soluble Vitamins
31
281
277
258
272
(269 293)
(269 285)
(251 266)
(267 277)
153
155
146
152
(144 162)
(148 160)
(139 151)
(148 155)
277
274
254
267
(266 288)
(265 282)
(246 262)
(263 270)
522
519
483
517
(499 556)
(500 540)
(464 506)
(497 534)
7,614
8,488
7,849
7,906
19992000
20012002
20032004
20052006
293
284
263
282
(282 306)
(273 296)
(253 273)
(269 295)
198
188
181
191
(182 206)
(163 201)
(172 187)
(181 197)
290
283
258
271
(283 301)
(270 296)
(245 268)
(265 281)
446
468
385
463
(397 608)
(394 522)
(364 583)
(432 598)
380
460
453
493
19992000
20012002
20032004
20052006
284
276
258
269
(275 293)
(266 287)
(251 265)
(260 277)
190
183
176
182
(177 202)
(171 189)
(170 183)
(173 189)
282
272
255
263
(274 292)
(260 283)
(246 264)
(257 271)
423
444
414
434
(389 502)
(422 512)
(372 447)
(396 494)
898
1,040
849
930
19992000
20012002
20032004
20052006
247
242
223
235
(237 256)
(231 253)
(217 230)
(229 241)
152
148
137
145
(146 158)
(138 157)
(129 145)
(133 151)
244
238
223
234
(238 255)
(228 249)
(215 230)
(228 240)
415
406
356
380
(391 456)
(381 446)
(338 386)
(358 414)
2,136
2,226
2,063
1,987
19992000
20012002
20032004
20052006
256
254
236
252
(244 268)
(246 263)
(228 245)
(244 261)
141
144
138
143
(130 150)
(134 152)
(131 143)
(138 150)
254
251
234
249
(237 270)
(240 262)
(221 245)
(242 256)
460
448
426
462
(439 515)
(432 471)
(403 461)
(428 525)
1,474
1,721
1,555
1,707
19992000
20012002
20032004
20052006
294
289
264
276
(279 311)
(280 298)
(253 275)
(270 282)
156
163
148
150
(144 167)
(155 170)
(137 156)
(145 155)
292
287
270
277
(274 309)
(281 295)
(258 279)
(270 284)
538
526
465
495
(502 613)
(484 585)
(430 514)
(465 544)
1,213
1,496
1,273
1,376
19992000
20012002
20032004
20052006
340
334
320
329
(328 352)
(323 345)
(310 329)
(316 342)
169
167
162
161
(154 182)
(158 178)
(154 171)
(155 168)
343
336
321
332
(323 363)
(325 349)
(310 337)
(312 347)
667
654
642
662
(629 701)
(608 721)
(589 725)
(618 733)
1,513
1,545
1,656
1,413
19992000
20012002
20032004
20052006
274
269
252
264
(262 286)
(259 278)
(244 260)
(257 271)
153
155
147
151
(144 161)
(147 160)
(138 153)
(144 157)
270
265
248
259
(259 280)
(254 276)
(239 257)
(255 264)
499
485
452
481
(478 526)
(465 520)
(431 485)
(459 508)
3,721
4,106
3,874
3,845
19992000
20012002
20032004
20052006
288
285
264
280
(275 301)
(276 294)
(256 273)
(273 287)
154
155
146
153
(142 164)
(148 159)
(138 151)
(148 157)
286
282
261
274
(272 298)
(274 291)
(251 271)
(267 282)
549
540
502
538
(515 590)
(518 575)
(483 530)
(528 557)
3,893
4,382
3,975
4,061
19992000
20012002
20032004
20052006
261
256
242
250
(253 268)
(244 268)
(234 251)
(244 256)
159
146
149
148
(151 166)
(132 161)
(136 157)
(129 158)
256
252
236
244
(251 262)
(241 265)
(231 244)
(239 249)
452
458
414
461
(429 465)
(434 497)
(398 462)
(452 482)
2,592
2,134
1,919
2,057
19992000
20012002
20032004
20052006
225
216
209
220
(218 233)
(210 222)
(203 214)
(215 224)
125
122
119
131
(113 135)
(119 124)
(114 127)
(124 136)
226
214
209
217
(221 234)
(208 220)
(204 214)
(212 221)
386
376
366
402
(366 427)
(355 412)
(349 389)
(376 422)
1,738
2,045
2,091
2,084
19992000
20012002
20032004
20052006
298
293
273
288
(281 315)
(286 300)
(262 285)
(281 295)
165
166
158
162
(147 175)
(160 172)
(146 166)
(155 167)
293
289
269
282
(275 309)
(283 295)
(258 280)
(276 289)
555
542
504
539
(527 592)
(524 566)
(485 531)
(527 567)
2,585
3,625
3,256
3,149
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
32
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
600
i
500
i
i
i
i
i
i
i
i
i
i
i
i
400
i
i
300
50th Percentile
350
300
i
i
250
i
i
i
i
i
i
i
i
i
i
i
i
i
200
200
i
i
i
i
150
i
i
i
i
i
i
i
i
i
i
i
i
i
i
i
i
i
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
100
9900
0102
0304
0506
5th Percentile
250
Total
(3+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
1. Water-Soluble Vitamins
33
16,670
0.2
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
1,861
1,779
4,050
3,262
2,649
3,069
0.2
0.4
Males
Females
8,172
8,498
0.2
0.3
(0.1 0.4)
(0.2 0.5)
301,000
404,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
4,304
4,404
6,675
0.3
0.9
(0.1 0.6)
(0.6 1.5)
72,000
313,000
Gender
Race/ethnicity
(0.2 0.4)
704,000
(0.1 0.4)
(0.2 0.7)
76,000
331,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
34
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,614
8,488
7,849
7,906
0.2
0.3
0.2
19992000
20012002
20032004
20052006
380
460
453
493
19992000
20012002
20032004
20052006
898
1,040
849
930
19992000
20012002
20032004
20052006
2,136
2,226
2,063
1,987
0.3
0.2
88,000
64,000
19992000
20012002
20032004
20052006
1,474
1,721
1,555
1,707
19992000
20012002
20032004
20052006
1,213
1,496
1,273
1,376
0.7
0.1
555,000
118,000
19992000
20012002
20032004
20052006
1,513
1,545
1,656
1,413
0.3
19992000
20012002
20032004
20052006
3,721
4,106
3,874
3,845
0.2
0.3
0.1
19992000
20012002
20032004
20052006
3,893
4,382
3,975
4,061
0.1
0.4
19992000
20012002
20032004
20052006
2,592
2,134
1,919
2,057
19992000
20012002
20032004
20052006
1,738
2,045
2,091
2,084
1.0
0.7
1.0
0.8
19992000
20012002
20032004
20052006
2,585
3,625
3,256
3,149
0.0
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
(0.1 0.4)
(0.2 0.6)
(0.1 0.3)
(0.1 0.5)
(0.1 0.4)
(0.3 1.5)
(0.1 0.3)
(0.1 0.7)
(0.1 0.4)
(0.1 0.6)
(0.1 0.2)
(0.1 0.3)
(0.2 0.9)
562,000
947,000
434,000
147,000
217,000
378,000
201,000
161,000
570,000
(0.5 1.7)
(0.3 1.5)
(0.5 1.9)
(0.3 1.8)
318,000
238,000
333,000
261,000
(0.0 0.1)
85,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
1. Water-Soluble Vitamins
35
36
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
49.3
40.5
53.8
56.0
47.4
65.0
60.5
49.4
51.0
49.0
50.4
51.4
(47.2 51.4)
(37.4 44.0)
(50.8 57.0)
(53.6 58.5)
(44.7 50.3)
(61.2 69.0)
(56.9 64.4)
(46.7 52.3)
(47.7 54.6)
(45.1 53.3)
(46.7 54.5)
(49.1 53.8)
Geometric mean
12.9
9.41
11.3
13.3
10.2
20.7
22.9
17.4
11.8
9.84
9.13
11.3
(10.8 14.7)
(8.45 10.5)
(9.84 12.8)
(11.7 14.5)
(9.46 11.2)
(18.2 23.6)
(20.0 24.1)
(16.4 18.4)
(10.3 13.7)
(8.61 11.3)
(8.70 9.95)
(10.0 12.5)
2.5th
17.5
12.7
14.1
17.1
12.9
25.4
25.5
20.7
15.6
12.8
11.6
14.3
(14.5 19.5)
(11.3 13.2)
(12.9 15.3)
(15.2 18.9)
(11.7 13.9)
(21.3 29.9)
(23.3 28.2)
(19.2 21.6)
(13.6 17.0)
(11.2 13.8)
(9.96 12.9)
(13.3 15.3)
5th
46.4
39.0
51.7
53.9
44.1
66.1
60.0
47.8
47.3
45.6
46.9
49.3
(44.9 48.3)
(35.9 41.7)
(49.5 54.6)
(52.0 56.0)
(40.8 47.0)
(63.1 70.4)
(55.3 65.5)
(44.9 51.0)
(43.9 50.5)
(41.5 50.3)
(41.9 53.5)
(46.9 51.2)
50th
157
155
234
209
222
160
157
127
219
262
262
214
(147 174)
(129 212)
(212 269)
(191 254)
(210 249)
(148 182)
(137 185)
(118 150)
(194 273)
(212 302)
(217 311)
(199 245)
95th
212
238
319
320
291
185
188
174
322
342
324
(190 262)
(183 302)
(289 344)
(282 352)
(266 323)
(176 202)
(169 223)
(140 206)
(279 379)
(297 399)
(281 385)
(279 330)
97.5th
302
2,212
2,157
3,285
4,055
4,256
915
922
1,985
1,699
1,381
1,409
8,311
Sample
size
Geometric mean and selected percentiles of serum concentrations (in nmol/L) for the total U.S. population aged 1 year and older, National
Health and Nutrition Examination Survey, 20052006.
20
40
60
Females
Males
Serum pyridoxal
5'phospate (nmol/L)
80
Overall
15
611
2039
4059
60+
15
611
2039
4059
60+
4059
60+
NonHispanic Whites
20
40
60
80
NonHispanic Blacks
1219
Serum pyridoxal
5'phospate (nmol/L)
1219
15
611
2039
4059
60+
15
611
80
Females
1219
2039
Males
20
40
60
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum pyridoxal
5'phospate (nmol/L)
1219
15
611
1219
2039
Age (years)
4059
60+
15
611
1219
2039
4059
60+
Age (years)
1. Water-Soluble Vitamins
37
51.4
65.0
60.5
49.4
51.0
49.0
50.4
(49.1 53.8)
(61.2 69.0)
(56.9 64.4)
(46.7 52.3)
(47.7 54.6)
(45.1 53.3)
(46.7 54.5)
19.5
31.7
30.7
24.8
20.0
16.5
15.1
(18.2 20.6)
(29.2 35.0)
(28.0 33.5)
(23.3 26.3)
(18.0 21.6)
(14.3 19.0)
(13.0 17.5)
49.3
66.1
60.0
47.8
47.3
45.6
46.9
(46.9 51.2)
(63.1 70.4)
(55.3 65.5)
(44.9 51.0)
(43.9 50.5)
(41.5 50.3)
(41.9 53.5)
154
126
126
105
153
166
187
(139 162)
(116 140)
(110 138)
(92.9 114)
(130 183)
(147 192)
(173 209)
8,311
915
922
1,985
1,699
1,381
1,409
56.0
65.3
62.0
55.4
61.6
52.1
49.3
(53.6 58.5)
(61.2 69.6)
(57.4 66.9)
(52.4 58.6)
(58.0 65.4)
(46.4 58.5)
(44.7 54.3)
22.6
31.6
31.6
28.9
26.8
19.1
16.1
(20.3 24.6)
(26.3 35.2)
(30.5 33.4)
(27.0 30.6)
(24.8 28.8)
(14.8 22.6)
(13.5 19.3)
53.9
66.8
60.8
54.8
55.3
51.0
45.9
(52.0 56.0)
(63.2 71.9)
(54.8 68.4)
(51.3 57.9)
(52.7 58.3)
(43.7 56.9)
(40.0 54.4)
149
127
130
110
165
158
171
(136 162)
(117 135)
(113 143)
(101 122)
(139 202)
(125 188)
(156 196)
4,055
455
454
991
741
680
734
47.4
64.6
59.1
43.7
42.4
46.4
51.4
(44.7 50.3)
(59.3 70.5)
(54.9 63.6)
(40.5 47.2)
(38.8 46.3)
(42.5 50.6)
(46.6 56.7)
17.2
32.1
29.7
21.8
16.5
14.4
14.1
(15.2 18.8)
(28.5 36.1)
(25.3 33.6)
(21.0 22.8)
(14.6 18.4)
(13.0 17.6)
(12.7 16.2)
44.1
65.2
58.3
41.4
37.6
41.6
47.6
(40.8 47.0)
(60.9 71.1)
(52.0 64.0)
(39.0 45.1)
(35.1 41.8)
(36.3 46.6)
(39.8 57.1)
156
124
118
90.6
132
172
206
(141 165)
(106 156)
(104 156)
(78.4 111)
(111 166)
(161 207)
(176 246)
4,256
460
468
994
958
701
675
Males
Females
49.3
64.2
58.3
46.0
47.1
47.9
42.0
(47.2 51.4)
(60.1 68.7)
(52.5 64.6)
(44.4 47.6)
(44.1 50.4)
(42.4 54.1)
(34.9 50.5)
22.3
32.4
30.3
24.7
20.4
20.2
15.0
(19.8 23.9)
(28.0 34.2)
(24.0 34.9)
(23.0 26.6)
(15.7 24.8)
(14.5 23.3)
(13.1 17.2)
46.4
65.0
56.4
44.4
42.9
42.2
38.6
(44.9 48.3)
(59.0 71.1)
(50.8 65.8)
(42.5 47.6)
(40.1 45.6)
(38.5 49.4)
(30.2 50.1)
121
126
116
91.1
127
141
142
(105 136)
(115 142)
(98.9 137)
(83.7 100)
(97.0 143)
(115 170)
(101 184)
2,212
322
321
657
453
249
210
56.4
67.0
61.4
53.0
57.2
56.7
37.8
(53.7 59.1)
(61.3 73.3)
(55.5 67.9)
(50.2 55.9)
(51.9 63.1)
(46.6 68.9)
(30.0 47.6)
27.9
30.4
32.0
28.2
29.4
24.0
14.7
(23.5 30.6)
(22.2 38.5)
(27.9 35.2)
(26.7 32.3)
(22.0 32.5)
(16.0 34.1)
(10.7 18.6)
53.7
67.7
57.5
51.6
51.9
53.3
35.6
(51.2 55.8)
(60.0 76.3)
(52.4 65.7)
(47.7 55.8)
(46.1 60.9)
(45.1 59.2)
(26.8 50.9)
124
129
126
104
135
122
95.5
(108 140)
(108 180)
(97.0 151)
(87.7 113)
(108 152)
(91.1 478)
(71.3 209)
1,056
153
157
318
200
123
105
42.6
61.5
55.1
39.6
37.3
40.2
45.7
(40.8 44.6)
(55.9 67.7)
(47.2 64.3)
(37.6 41.7)
(34.3 40.4)
(35.0 46.3)
(36.9 56.6)
19.1
33.2
27.6
20.7
17.7
14.9
16.6
(16.4 20.8)
(28.9 34.9)
(17.6 34.7)
(19.0 22.6)
(11.8 19.6)
(10.3 18.9)
(12.6 19.8)
39.4
61.2
54.3
38.8
34.1
33.2
39.3
(38.2 40.3)
(55.2 68.8)
(44.6 68.7)
(37.2 39.7)
(31.7 36.1)
(29.7 39.1)
(30.7 53.3)
111
120
105
76.8
89.7
155
160
(96.5 130)
(97.3 176)
(87.9 133)
(69.9 87.9)
(71.6 134)
(110 199)
(106 212)
1,156
169
164
339
253
126
105
Males
Females
38
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
40.5
54.0
50.6
41.0
40.5
39.9
31.3
(37.4 44.0)
(49.4 58.9)
(45.4 56.4)
(38.1 44.1)
(36.8 44.5)
(33.5 47.5)
(26.8 36.6)
16.3
25.2
27.2
21.6
16.3
14.9
10.7
(15.4 17.2)
(22.3 29.5)
(25.0 29.8)
(19.8 22.7)
(13.2 18.1)
(13.2 17.4)
(8.73 12.6)
39.0
51.2
46.4
39.5
38.5
36.3
29.1
(35.9 41.7)
(46.4 58.8)
(41.9 55.9)
(37.1 43.2)
(35.3 43.5)
(31.1 41.7)
(24.5 35.7)
104
115
97.1
82.8
105
132
104
(90.5 132)
(99.1 138)
(90.0 123)
(73.6 90.9)
(94.0 142)
(82.8 204)
(79.0 152)
2,157
226
254
676
371
339
291
44.3
55.4
53.5
44.6
47.5
41.2
33.0
(40.5 48.6)
(49.5 61.9)
(47.2 60.7)
(40.6 48.9)
(41.2 54.8)
(34.9 48.7)
(27.9 39.1)
19.0
24.6
29.6
22.9
19.7
16.0
12.4
(17.3 20.1)
(19.3 32.2)
(26.0 31.8)
(21.1 25.1)
(14.5 23.5)
(9.17 20.7)
(10.2 13.4)
43.7
53.6
52.5
44.5
45.2
40.7
27.9
(39.3 47.3)
(46.6 60.4)
(41.9 61.7)
(38.8 49.5)
(37.7 53.5)
(31.6 46.6)
(24.1 38.1)
104
120
100
89.2
130
102
103
(92.0 137)
(103 147)
(92.0 124)
(74.9 103)
(95.2 185)
(79.6 203)
(79.1 194)
1,071
109
133
348
170
157
154
37.5
52.5
47.9
37.7
35.4
38.8
30.2
(34.2 41.1)
(46.3 59.4)
(42.4 54.2)
(35.2 40.3)
(32.2 38.9)
(30.8 48.9)
(24.5 37.2)
14.8
26.0
25.0
20.7
14.4
14.4
9.48
(13.4 16.1)
(11.1 30.5)
(22.9 29.8)
(18.7 21.6)
(9.31 16.8)
(13.0 16.1)
(8.20 11.2)
35.6
51.1
42.9
36.8
33.8
33.8
29.9
(32.3 39.2)
(42.8 59.8)
(38.0 52.0)
(33.7 39.1)
(28.4 37.9)
(26.5 41.0)
(22.4 37.0)
103
109
93.0
73.6
99.7
145
95.0
(85.9 128)
(88.7 149)
(84.6 128)
(68.9 85.6)
(80.0 141)
(81.3 261)
(74.2 157)
1,086
117
121
328
201
182
137
Males
Females
53.8
68.5
63.9
52.7
54.3
50.6
53.2
(50.8 57.0)
(63.0 74.4)
(58.7 69.5)
(48.7 57.1)
(48.9 60.3)
(45.6 56.1)
(49.0 57.9)
19.2
34.0
31.6
25.7
20.9
16.2
15.7
(17.7 20.7)
(30.5 37.3)
(29.2 34.2)
(23.8 27.2)
(17.7 22.7)
(13.7 19.0)
(13.3 18.2)
51.7
68.4
63.3
51.5
50.6
47.9
50.6
(49.5 54.6)
(63.3 77.5)
(54.9 72.7)
(47.4 56.8)
(44.9 55.8)
(42.7 52.8)
(44.0 57.5)
167
130
133
109
168
173
196
(156 181)
(114 157)
(117 170)
(96.0 127)
(133 211)
(153 199)
(177 215)
3,285
263
251
505
718
691
857
58.8
68.7
63.9
60.3
65.9
54.7
52.0
(55.1 62.7)
(62.9 74.9)
(57.3 71.4)
(55.5 65.5)
(60.4 72.0)
(47.4 63.2)
(46.4 58.2)
22.8
34.9
31.6
29.5
27.9
19.1
16.7
(20.2 25.5)
(30.2 37.2)
(29.3 33.7)
(27.3 33.8)
(25.3 30.8)
(14.6 22.8)
(13.7 20.5)
57.4
70.8
64.7
59.7
58.4
53.1
50.4
(53.8 60.6)
(65.3 78.3)
(50.1 75.8)
(54.7 65.2)
(53.9 66.8)
(43.6 61.7)
(42.2 59.3)
166
126
135
117
183
173
174
(147 183)
(115 137)
(106 190)
(105 148)
(152 228)
(140 194)
(157 204)
1,636
146
121
255
310
356
448
49.4
68.3
63.8
45.6
44.6
46.8
54.3
(45.8 53.2)
(59.0 79.0)
(56.8 71.8)
(41.0 50.8)
(39.3 50.7)
(42.2 52.0)
(48.6 60.6)
16.4
32.6
31.3
21.8
16.5
13.9
14.6
(14.4 18.7)
(26.5 40.3)
(23.7 35.9)
(19.7 23.9)
(14.4 18.8)
(12.6 16.4)
(12.5 17.0)
46.4
66.6
62.7
42.1
38.4
44.4
50.6
(42.5 50.4)
(59.0 79.5)
(51.7 74.6)
(39.0 47.8)
(34.5 45.7)
(35.8 48.3)
(41.6 62.5)
170
141
126
94.0
156
174
213
(161 182)
(105 183)
(108 175)
(80.0 126)
(112 216)
(155 221)
(184 254)
1,649
117
130
250
408
335
409
Males
Females
1. Water-Soluble Vitamins
39
8,311
10.5
(9.1 12.0)
30,146,000
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
915
922
1,985
1,699
1,381
1,409
2.1
1.2
4.6
9.9
13.9
16.0
(1.1 4.2)
(0.5 2.7)
(3.6 5.7)
(7.7 12.6)
(11.2 17.1)
(13.1 19.5)
435,000
280,000
1,529,000
7,877,000
11,371,000
7,741,000
Males
Females
4,055
4,256
7.3
13.5
(5.7 9.4)
(11.7 15.5)
10,305,000
19,830,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
2,212
2,157
3,285
7.5
15.7
10.7
(5.3 10.4)
(13.6 18.0)
(9.1 12.5)
2,031,000
5,459,000
20,588,000
Gender
Race/ethnicity
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
40
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
1. Water-Soluble Vitamins
41
42
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
22.5
21.6
37.1
32.1
31.8
25.9
23.5
20.9
26.8
34.7
58.6
31.9
(21.0 24.1)
(19.4 24.0)
(35.1 39.1)
(30.0 34.2)
(30.2 33.5)
(23.8 28.2)
(21.8 25.5)
(19.9 22.0)
(24.3 29.5)
(31.9 37.7)
(54.7 62.9)
(30.3 33.7)
Geometric mean
7.90
7.21
9.65
9.24
8.21
8.90
8.11
7.74
8.02
9.36
11.6
8.73
(7.09 8.46)
(6.78 7.57)
(9.04 10.1)
(8.43 9.77)
(7.89 8.65)
(8.00 9.22)
(7.12 8.98)
(7.17 8.22)
(7.49 8.47)
(8.56 10.0)
(10.2 12.4)
(8.19 9.06)
2.5th
9.13
8.04
11.1
10.6
9.50
10.5
9.46
8.85
9.16
10.7
13.1
9.87
(8.66 9.55)
(7.72 8.44)
(10.6 11.5)
(9.91 11.2)
(9.15 9.76)
(9.07 11.3)
(8.57 10.2)
(8.28 9.47)
(8.78 9.53)
(9.90 11.4)
(12.3 14.1)
(9.53 10.2)
5th
19.0
17.8
29.3
26.0
24.7
24.2
21.6
19.0
22.2
27.3
47.6
25.5
(18.1 20.1)
(16.3 19.3)
(27.8 30.6)
(24.9 27.4)
(23.4 26.1)
(22.2 25.8)
(19.8 23.9)
(18.2 20.1)
(20.4 23.9)
(25.8 29.1)
(45.0 52.3)
(24.6 26.5)
50th
90.9
119
224
171
214
96.9
85.6
70.5
160
212
464
194
(74.7 136)
(89.8 196)
(203 265)
(146 212)
(188 255)
(75.6 125)
(64.3 115)
(59.8 84.4)
(125 198)
(162 344)
(355 611)
(174 223)
95th
169
232
498
334
465
130
111
94.5
271
705
873
(127 355)
(159 493)
(370 717)
(271 427)
(349 712)
(104 214)
(92.4 133)
(79.4 131)
(184 447)
(278 2,150)
(557 1,700)
(329 505)
97.5th
385
2,213
2,157
3,285
4,055
4,257
917
922
1,985
1,698
1,381
1,409
8,312
Sample
size
Geometric mean and selected percentiles of serum concentrations (in nmol/L) for the total U.S. population aged 1 year and older, National
Health and Nutrition Examination Survey, 20052006.
20
40
60
Females
Males
15
611
2039
4059
60+
15
611
2039
4059
60+
4059
60+
NonHispanic Whites
20
40
60
80
1219
1219
NonHispanic Blacks
15
611
1219
2039
4059
60+
15
611
80
Females
1219
2039
Males
20
40
60
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Mexican Americans
80
Overall
15
611
1219
2039
Age (years)
4059
60+
15
611
1219
2039
4059
60+
Age (years)
1. Water-Soluble Vitamins
43
31.9
25.9
23.5
20.9
26.8
34.7
58.6
(30.3 33.7)
(23.8 28.2)
(21.8 25.5)
(19.9 22.0)
(24.3 29.5)
(31.9 37.7)
(54.7 62.9)
11.7
12.5
11.2
10.2
10.7
12.6
16.4
(11.4 12.2)
(11.4 13.3)
(10.2 12.0)
(9.88 10.6)
(10.0 11.1)
(11.8 13.6)
(14.9 18.3)
25.5
24.2
21.6
19.0
22.2
27.3
47.6
(24.6 26.5)
(22.2 25.8)
(19.8 23.9)
(18.2 20.1)
(20.4 23.9)
(25.8 29.1)
(45.0 52.3)
116
59.8
56.7
48.1
90.9
117
248
(105 128)
(49.8 79.6)
(48.4 71.5)
(44.1 54.5)
(73.2 115)
(105 138)
(208 321)
8,312
917
922
1,985
1,698
1,381
1,409
32.1
26.7
24.0
23.3
29.0
33.0
56.7
(30.0 34.2)
(23.7 30.0)
(22.1 26.1)
(21.9 24.7)
(26.1 32.2)
(29.3 37.2)
(50.7 63.5)
12.9
11.9
11.6
11.9
12.0
13.8
17.2
(12.1 13.6)
(10.5 14.1)
(9.92 12.4)
(10.9 12.6)
(10.9 13.2)
(11.8 15.2)
(15.1 18.9)
26.0
25.2
21.9
20.8
24.3
26.5
46.8
(24.9 27.4)
(22.8 27.0)
(20.2 24.1)
(19.7 21.9)
(22.5 26.0)
(24.4 30.2)
(41.8 53.3)
103
63.6
56.4
55.0
89.5
101
220
(92.2 118)
(48.5 111)
(46.0 83.0)
(46.8 67.0)
(65.9 124)
(76.3 124)
(178 292)
4,055
456
454
991
740
680
734
31.8
25.1
23.0
18.7
24.8
36.4
60.2
(30.2 33.5)
(23.3 27.1)
(20.5 25.8)
(17.7 19.8)
(22.3 27.5)
(33.3 39.8)
(56.1 64.8)
11.1
12.6
10.7
9.59
9.74
12.1
15.6
(10.9 11.3)
(11.9 13.0)
(9.57 11.5)
(9.31 9.88)
(9.31 10.4)
(11.3 12.7)
(14.0 17.9)
24.7
22.7
20.8
17.1
19.2
28.1
48.7
(23.4 26.1)
(20.8 25.4)
(18.6 24.2)
(16.3 18.0)
(17.3 22.1)
(25.2 31.1)
(43.5 56.9)
133
59.2
54.9
42.9
92.5
145
257
(116 151)
(48.3 76.4)
(44.7 90.5)
(35.5 52.2)
(77.5 118)
(116 192)
(219 328)
4,257
461
468
994
958
701
675
Males
Females
Geometric mean
10th
50th
90th
Sample
size
22.5
22.7
19.6
17.1
21.6
27.9
33.8
(21.0 24.1)
(20.7 24.8)
(17.7 21.7)
(16.4 17.8)
(19.3 24.1)
(24.6 31.6)
(27.9 41.0)
10.7
11.9
9.67
9.29
10.7
11.7
12.5
(10.0 11.2)
(10.7 12.8)
(8.75 10.7)
(8.70 9.81)
(9.33 11.4)
(10.1 12.7)
(11.0 14.7)
19.0
20.3
18.5
15.8
18.3
22.4
27.3
(18.1 20.1)
(19.1 22.2)
(16.0 20.3)
(14.8 16.8)
(16.8 19.9)
(20.5 24.6)
(23.6 31.2)
57.9
52.3
44.2
34.6
53.3
71.1
117
(48.0 66.1)
(41.3 62.3)
(36.3 58.1)
(31.5 42.8)
(43.8 76.4)
(60.0 114)
(75.3 311)
2,213
324
321
657
452
249
210
23.6
23.3
20.7
19.4
23.0
29.7
28.2
(21.9 25.6)
(20.4 26.5)
(18.2 23.6)
(18.2 20.6)
(20.1 26.2)
(24.2 36.4)
(22.0 36.1)
11.5
11.8
10.3
10.3
11.2
12.9
11.6
(10.8 12.0)
(10.7 13.7)
(8.64 11.4)
(9.71 10.8)
(9.36 12.7)
(12.5 13.9)
(5.00 14.6)
20.7
20.9
18.9
17.3
19.5
24.2
26.0
(19.4 21.7)
(18.9 22.9)
(16.5 20.9)
(16.8 18.4)
(17.6 22.2)
(21.2 28.4)
(19.9 33.3)
58.1
48.8
47.4
41.6
55.0
65.1
72.5
(45.6 68.9)
(38.0 78.1)
(39.5 59.3)
(34.1 59.2)
(42.2 85.5)
(45.1 230)
(50.8 193)
1,057
155
157
318
199
123
105
21.4
22.0
18.5
15.0
20.0
26.1
39.2
(20.1 22.7)
(19.9 24.4)
(16.3 21.1)
(14.3 15.8)
(17.6 22.8)
(22.4 30.3)
(30.0 51.4)
9.91
11.9
9.60
8.55
9.73
10.9
13.9
(9.35 10.6)
(9.70 12.5)
(7.35 10.7)
(7.66 9.16)
(7.90 11.1)
(9.79 11.6)
(11.1 15.7)
17.3
20.2
17.3
14.1
16.3
19.1
28.0
(16.4 18.3)
(17.5 22.6)
(15.1 20.4)
(13.2 15.1)
(14.7 18.6)
(14.7 25.2)
(23.3 35.2)
57.0
52.3
41.2
28.2
49.5
90.5
162
(49.5 70.1)
(38.6 64.8)
(31.1 53.4)
(25.2 33.6)
(41.4 81.1)
(54.6 289)
(78.4 3,380)
1,156
169
164
339
253
126
105
Males
Females
44
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
21.6
22.2
17.8
14.8
19.3
25.3
33.8
(19.4 24.0)
(19.2 25.8)
(16.0 19.8)
(14.0 15.7)
(18.1 20.7)
(21.3 30.0)
(26.3 43.4)
9.28
10.1
9.03
8.28
8.89
9.62
12.2
(8.85 9.59)
(8.17 11.2)
(8.25 9.53)
(7.64 8.65)
(8.39 9.47)
(8.24 10.8)
(9.71 14.1)
17.8
19.5
15.3
13.9
15.4
19.2
27.4
(16.3 19.3)
(17.6 22.5)
(14.3 17.4)
(13.1 14.6)
(14.2 17.6)
(17.6 21.2)
(23.1 30.6)
60.5
61.7
43.9
28.9
51.4
103
113
(51.3 81.9)
(44.0 96.8)
(32.5 67.1)
(25.7 34.0)
(45.3 60.6)
(57.1 164)
(81.9 246)
2,157
226
254
676
371
339
291
21.8
24.5
18.4
16.2
19.7
25.1
33.2
(19.7 24.3)
(20.6 29.1)
(16.2 21.0)
(15.0 17.5)
(17.6 22.2)
(21.7 29.0)
(27.1 40.7)
9.68
10.3
9.50
9.11
9.68
9.58
12.5
(9.16 10.3)
(6.27 12.2)
(8.53 10.3)
(8.59 9.35)
(8.96 10.9)
(7.97 10.6)
(11.8 13.4)
18.5
20.9
15.9
15.5
17.4
19.3
24.3
(17.3 20.0)
(17.7 24.4)
(14.5 18.5)
(14.1 16.5)
(14.3 20.4)
(17.7 20.8)
(22.7 30.2)
55.7
83.7
44.1
30.9
44.3
71.2
109
(44.4 82.8)
(48.8 152)
(33.3 66.5)
(26.8 39.1)
(32.7 68.2)
(52.9 134)
(80.8 246)
1,070
108
133
348
170
157
154
21.3
20.1
17.2
13.5
19.0
25.4
34.2
(18.7 24.3)
(16.7 24.2)
(15.1 19.7)
(12.6 14.4)
(16.9 21.5)
(19.2 33.7)
(24.3 48.1)
8.88
8.59
8.50
7.56
8.42
9.64
11.6
(8.38 9.44)
(7.62 11.1)
(7.72 9.43)
(6.46 8.33)
(7.62 8.98)
(7.95 11.0)
(8.02 15.3)
17.1
19.0
14.8
12.7
14.3
18.8
28.0
(15.0 19.1)
(16.1 22.5)
(13.1 17.4)
(11.8 13.4)
(12.7 16.9)
(15.5 25.8)
(21.9 33.8)
64.9
42.6
40.6
25.6
57.7
107
116
(52.5 94.0)
(34.5 65.2)
(31.1 86.4)
(22.0 32.8)
(45.3 85.7)
(53.1 217)
(75.1 431)
1,087
118
121
328
201
182
137
Males
Females
Geometric mean
10th
50th
90th
Sample
size
37.1
28.4
26.7
24.1
31.2
37.7
64.4
(35.1 39.1)
(25.2 31.8)
(24.1 29.5)
(22.4 26.0)
(27.5 35.4)
(34.1 41.6)
(58.5 70.9)
13.2
13.6
12.6
11.5
11.5
13.7
18.2
(12.6 13.8)
(11.9 15.1)
(11.8 13.3)
(10.6 12.8)
(10.7 12.6)
(12.5 14.8)
(15.3 20.2)
29.3
26.7
24.5
21.5
25.2
30.2
53.7
(27.8 30.6)
(24.2 29.2)
(22.4 26.0)
(21.0 22.2)
(22.6 28.1)
(27.9 32.2)
(48.7 57.9)
138
59.9
63.5
55.9
113
130
257
(120 154)
(49.8 104)
(50.7 96.3)
(47.7 74.7)
(89.1 155)
(111 148)
(220 328)
3,285
263
251
505
718
691
857
36.8
29.0
26.4
27.1
33.6
35.5
62.6
(34.1 39.6)
(24.9 33.7)
(23.7 29.5)
(25.0 29.4)
(29.4 38.4)
(30.7 41.1)
(54.1 72.5)
14.9
14.0
12.5
14.2
14.4
14.9
18.8
(13.7 15.7)
(9.91 16.0)
(11.7 13.9)
(13.4 15.5)
(12.0 15.6)
(12.5 17.5)
(15.9 21.2)
29.5
27.2
24.9
23.5
26.9
29.3
52.3
(27.7 31.3)
(24.5 31.1)
(21.6 26.0)
(21.4 26.1)
(24.2 29.4)
(26.0 33.1)
(44.8 60.1)
116
59.8
66.7
64.0
105
102
232
(105 136)
(47.3 130)
(45.2 92.9)
(54.7 80.3)
(71.2 187)
(81.5 141)
(195 344)
1,636
146
121
255
310
356
448
37.3
27.7
26.9
21.2
29.0
39.9
65.9
(35.4 39.4)
(24.5 31.3)
(22.4 32.3)
(19.2 23.5)
(25.5 33.0)
(35.9 44.5)
(60.1 72.4)
12.4
13.1
12.5
10.2
10.6
12.8
17.6
(11.6 12.7)
(11.1 15.1)
(10.7 13.7)
(9.58 11.0)
(9.87 11.0)
(12.1 13.6)
(14.1 20.4)
29.2
25.4
24.3
19.8
23.1
30.5
54.9
(26.8 31.4)
(20.8 29.9)
(20.7 29.2)
(18.0 21.1)
(19.3 26.9)
(26.6 34.8)
(47.4 63.8)
155
59.9
62.1
47.3
117
155
270
(136 176)
(49.8 99.2)
(47.7 189)
(40.3 69.4)
(90.2 161)
(128 223)
(242 343)
1,649
117
130
250
408
335
409
Males
Females
1. Water-Soluble Vitamins
45
46
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
549
565
482
500
500
804
728
510
454
466
482
500
(530 569)
(550 580)
(470 495)
(490 509)
(487 514)
(776 833)
(713 743)
(499 521)
(443 465)
(451 482)
(468 496)
(489 511)
Geometric mean
224
223
201
216
200
327
354
238
210
197
166
206
(212 241)
(210 233)
(194 209)
(210 222)
(189 206)
(280 368)
(342 363)
(224 250)
(201 214)
(177 210)
(151 179)
(201 212)
2.5th
260
266
229
249
227
397
396
271
231
226
210
236
(248 274)
(258 276)
(222 239)
(238 259)
(216 236)
(344 432)
(367 431)
(264 277)
(223 243)
(214 237)
(202 217)
(227 244)
5th
527
556
478
494
495
814
724
509
451
460
481
495
(513 547)
(537 576)
(465 491)
(484 505)
(480 508)
(783 858)
(707 747)
(495 526)
(441 462)
(446 475)
(466 499)
(483 505)
50th
1,170
1,240
1,040
1,030
1,140
1,520
1,280
938
884
1,020
1,070
1,090
(1,110 1,240)
(1,200 1,320)
(999 1,080)
(994 1,060)
(1,100 1,180)
(1,470 1,630)
(1,240 1,350)
(901 975)
(859 904)
(934 1,100)
(1,020 1,190)
(1,050 1,110)
95th
1,600
1,430
1,230
1,200
1,370
1,710
1,440
1,050
1,010
1,180
1,380
1,300
(1,370 1,950)
(1,370 1,540)
(1,170 1,310)
(1,150 1,240)
(1,330 1,410)
(1,600 1,810)
(1,360 1,570)
(1,020 1,140)
(962 1,060)
(1,110 1,350)
(1,280 1,570)
(1,250 1,340)
97.5th
4,205
4,285
6,571
7,999
8,317
1,678
1,747
4,013
3,214
2,629
3,035
16,316
Sample
size
Geometric mean and selected percentiles of serum concentrations (in pg/mL) for the total U.S. population aged 1 year and older, National Health
and Nutrition Examination Survey, 20032006.
500
Females
Males
1000
Overall
15
611
2039
4059
60+
15
611
2039
4059
60+
4059
60+
NonHispanic Whites
500
1000
NonHispanic Blacks
1219
1219
15
611
2039
4059
60+
15
611
1000
Females
1219
2039
Males
500
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
1219
15
611
1219
2039
Age (years)
4059
60+
15
611
1219
2039
4059
60+
Age (years)
1. Water-Soluble Vitamins
47
Geometric mean
5th
50th
95th
Sample
size
500
804
728
510
454
466
482
(489 511)
(776 833)
(713 743)
(499 521)
(443 465)
(451 482)
(468 496)
236
397
396
271
231
226
210
(227 244)
(344 432)
(367 431)
(264 277)
(223 243)
(214 237)
(202 217)
495
814
724
509
451
460
481
(483 505)
(783 858)
(707 747)
(495 526)
(441 462)
(446 475)
(466 499)
1,090
1,520
1,280
938
884
1,020
1,070
(1,050 1,110)
(1,470 1,630)
(1,240 1,350)
(901 975)
(859 904)
(934 1,100)
(1,020 1,190)
16,316
1,678
1,747
4,013
3,214
2,629
3,035
500
796
722
513
469
456
461
(490 509)
(761 832)
(701 744)
(500 526)
(456 483)
(440 472)
(447 475)
249
379
411
292
258
226
210
(238 259)
(302 423)
(363 439)
(272 309)
(242 270)
(212 246)
(193 223)
494
816
735
510
469
456
458
(484 505)
(775 862)
(713 761)
(494 534)
(454 485)
(442 469)
(442 480)
1,030
1,470
1,220
904
856
896
990
(994 1,060)
(1,430 1,520)
(1,140 1,270)
(866 951)
(820 893)
(825 985)
(937 1,100)
7,999
844
853
2,031
1,451
1,296
1,524
500
813
734
506
439
476
499
(487 514)
(781 847)
(710 758)
(492 520)
(425 453)
(455 499)
(479 521)
227
401
393
254
217
223
210
(216 236)
(343 444)
(362 421)
(243 266)
(206 227)
(200 241)
(200 218)
495
810
714
507
431
467
504
(480 508)
(772 863)
(687 748)
(487 526)
(420 446)
(444 489)
(477 530)
1,140
1,560
1,360
973
909
1,090
1,140
(1,100 1,180)
(1,470 1,740)
(1,290 1,460)
(928 1,050)
(868 980)
(1,020 1,160)
(1,050 1,310)
8,317
834
894
1,982
1,763
1,333
1,511
Males
Females
Geometric mean
5th
95th
549
833
730
508
483
535
496
(530 569)
(802 866)
(708 753)
(493 524)
(463 503)
(491 582)
(465 528)
260
450
409
270
249
248
220
(248 274)
(417 468)
(367 441)
(250 295)
(225 260)
(207 274)
(193 239)
527
842
729
505
467
483
458
(513 547)
(811 880)
(704 762)
(486 525)
(449 493)
(457 515)
(435 489)
1,170
1,480
1,210
909
955
1,310
1,240
(1,110 1,240)
(1,390 1,670)
(1,150 1,290)
(873 951)
(883 1,150)
(996 3,160)
(1,070 2,490)
4,205
540
587
1,280
778
468
552
526
801
724
498
467
493
456
(510 543)
(766 838)
(696 752)
(478 519)
(443 492)
(460 529)
(412 505)
258
423
386
271
252
249
224
(251 267)
(364 467)
(345 462)
(239 305)
(217 264)
(191 263)
(195 237)
513
805
735
494
459
463
404
(492 533)
(776 844)
(705 771)
(476 516)
(431 494)
(446 494)
(376 448)
1,060
1,450
1,150
866
855
1,050
1,210
(1,010 1,110)
(1,330 1,630)
(1,080 1,250)
(810 920)
(794 978)
(915 2,230)
(929 5,710)
2,036
261
285
637
345
236
272
574
869
738
519
501
582
531
(548 602)
(824 916)
(704 772)
(502 536)
(476 528)
(500 678)
(475 594)
263
456
413
269
248
243
210
(241 288)
(420 500)
(370 441)
(255 291)
(220 271)
(182 306)
(169 258)
550
887
716
518
476
520
494
(522 573)
(834 910)
(690 762)
(495 549)
(452 509)
(464 574)
(459 537)
1,290
1,590
1,280
951
1,190
1,950
1,370
(1,180 1,630)
(1,400 1,890)
(1,160 1,620)
(892 1,060)
(984 2,080)
(1,010 6,830)
(1,110 2,950)
2,169
279
302
643
433
232
280
Males
Females
48
50th
Sample
size
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
5th
50th
95th
Sample
size
565
885
827
570
499
524
530
(550 580)
(835 938)
(800 854)
(557 584)
(483 516)
(506 543)
(504 558)
266
431
448
284
259
264
225
(258 276)
(340 479)
(398 470)
(270 297)
(227 277)
(220 286)
(199 252)
556
899
817
571
497
515
531
(537 576)
(827 965)
(800 842)
(551 585)
(480 512)
(494 544)
(505 565)
1,240
1,770
1,560
1,110
941
1,120
1,240
(1,200 1,320)
(1,550 2,020)
(1,440 1,670)
(1,050 1,160)
(894 1,050)
(1,070 1,200)
(1,100 1,510)
4,285
476
553
1,415
706
622
513
564
896
799
567
512
510
502
(549 580)
(821 977)
(762 837)
(550 585)
(488 536)
(482 539)
(472 533)
267
418
428
294
277
241
211
(257 282)
(293 494)
(350 466)
(268 322)
(256 290)
(204 269)
(142 241)
546
910
811
567
507
509
494
(533 571)
(822 1,010)
(743 840)
(541 585)
(482 527)
(488 541)
(459 521)
1,230
1,800
1,540
1,040
950
988
1,220
(1,140 1,320)
(1,570 2,150)
(1,370 1,780)
(993 1,140)
(872 1,160)
(863 1,250)
(998 1,770)
2,136
236
272
742
337
292
257
565
874
856
574
489
536
551
(545 587)
(829 922)
(815 899)
(558 590)
(464 515)
(507 566)
(514 590)
265
431
468
272
231
273
232
(233 282)
(257 489)
(383 501)
(259 288)
(207 271)
(219 295)
(187 265)
563
880
834
576
487
527
576
(531 597)
(798 957)
(801 887)
(551 595)
(460 518)
(492 568)
(524 613)
1,250
1,650
1,570
1,160
938
1,170
1,280
(1,200 1,340)
(1,470 2,050)
(1,430 1,710)
(1,110 1,210)
(880 1,080)
(1,100 1,400)
(1,110 1,620)
2,149
240
281
673
369
330
256
Males
Females
Geometric mean
5th
50th
95th
Sample
size
482
769
707
496
440
453
476
(470 495)
(730 810)
(686 729)
(484 509)
(426 455)
(435 471)
(461 492)
229
375
392
269
226
225
209
(222 239)
(298 411)
(345 435)
(253 276)
(215 238)
(208 236)
(200 217)
478
777
703
498
438
448
477
(465 491)
(730 830)
(674 734)
(481 517)
(424 452)
(434 465)
(460 499)
1,040
1,470
1,230
887
853
980
1,050
(999 1,080)
(1,410 1,560)
(1,170 1,350)
(833 952)
(814 889)
(867 1,090)
(990 1,170)
6,571
476
448
1,042
1,434
1,340
1,831
487
764
708
507
468
447
454
(475 498)
(720 811)
(678 740)
(492 522)
(448 488)
(430 465)
(439 469)
244
353
405
293
263
226
208
(228 256)
(261 416)
(343 441)
(271 316)
(230 275)
(199 248)
(181 221)
483
799
715
505
469
448
455
(471 496)
(739 861)
(680 753)
(486 535)
(448 493)
(435 464)
(434 481)
981
1,380
1,160
847
826
879
952
(946 1,030)
(1,320 1,500)
(1,080 1,250)
(803 941)
(786 900)
(781 984)
(887 1,050)
3,235
254
216
523
631
682
929
478
774
706
485
414
458
494
(462 494)
(721 831)
(671 743)
(470 501)
(398 431)
(432 485)
(471 519)
220
381
377
246
211
220
210
(210 230)
(325 431)
(316 421)
(226 259)
(197 223)
(199 236)
(199 217)
471
763
679
486
405
447
500
(454 488)
(700 835)
(648 742)
(468 508)
(387 427)
(419 483)
(470 523)
1,080
1,530
1,340
913
874
1,040
1,090
(1,040 1,140)
(1,450 1,760)
(1,180 1,490)
(842 1,030)
(797 936)
(900 1,180)
(1,030 1,320)
3,336
222
232
519
803
658
902
Males
Females
1. Water-Soluble Vitamins
49
487
488
489
502
(481 494)
(479 497)
(472 507)
(489 516)
240
236
238
231
(234 245)
(232 241)
(225 252)
(221 242)
483
485
486
497
(474 494)
(474 494)
(467 500)
(482 511)
993
1,000
1,020
1,100
(970 1,040)
(971 1,040)
(979 1,080)
(1,060 1,130)
7,524
8,390
7,837
7,694
19992000
20012002
20032004
20052006
757
804
768
877
(682 839)
(773 837)
(716 824)
(841 913)
441
471
393
482
(321 459)
(426 518)
(285 422)
(437 507)
735
815
775
894
(663 827)
(783 836)
(716 852)
(826 950)
1,380
1,380
1,550
1,470
(1,300 1,730)
(1,250 1,560)
(1,310 1,800)
(1,430 1,660)
361
439
449
444
19992000
20012002
20032004
20052006
695
691
711
745
(659 733)
(669 714)
(689 733)
(721 769)
362
386
375
418
(330 401)
(340 412)
(344 419)
(381 442)
704
696
714
741
(676 738)
(672 724)
(679 736)
(710 768)
1,250
1,270
1,240
1,290
(1,170 1,340)
(1,190 1,330)
(1,190 1,360)
(1,230 1,370)
885
1,022
843
904
19992000
20012002
20032004
20052006
501
511
500
519
(491 511)
(495 528)
(483 518)
(505 534)
263
269
267
273
(235 280)
(256 289)
(255 282)
(269 281)
506
516
504
519
(494 518)
(496 536)
(481 528)
(496 544)
954
934
911
966
(905 1,010)
(899 983)
(871 949)
(907 1,040)
2,123
2,208
2,059
1,954
19992000
20012002
20032004
20052006
445
445
451
457
(438 451)
(432 458)
(434 468)
(443 472)
234
230
240
227
(219 240)
(217 239)
(225 253)
(214 239)
448
445
449
452
(432 459)
(432 457)
(431 465)
(440 468)
807
822
826
913
(791 824)
(776 893)
(787 888)
(889 964)
1,470
1,715
1,555
1,659
19992000
20012002
20032004
20052006
460
460
460
472
(447 474)
(450 471)
(435 486)
(452 493)
234
232
226
223
(208 256)
(221 238)
(215 243)
(195 244)
447
456
456
464
(432 466)
(443 465)
(438 479)
(444 485)
909
942
957
1,060
(861 952)
(879 1,020)
(833 1,110)
(984 1,130)
1,198
1,478
1,276
1,353
19992000
20012002
20032004
20052006
482
473
477
487
(467 496)
(455 491)
(459 496)
(466 508)
228
220
208
211
(212 243)
(204 231)
(198 221)
(197 219)
470
479
477
495
(460 483)
(465 493)
(454 494)
(464 511)
1,030
1,000
1,060
1,070
(950 1,130)
(962 1,030)
(967 1,310)
(1,030 1,220)
1,487
1,528
1,655
1,380
19992000
20012002
20032004
20052006
487
490
490
500
(479 495)
(476 505)
(476 505)
(487 514)
255
247
250
247
(235 264)
(235 257)
(229 266)
(226 259)
488
485
486
497
(478 498)
(468 497)
(469 499)
(482 512)
956
963
971
1,040
(901 1,020)
(919 1,010)
(944 1,020)
(987 1,110)
3,682
4,059
3,871
3,740
19992000
20012002
20032004
20052006
488
486
488
504
(481 495)
(476 496)
(467 509)
(486 523)
233
230
228
224
(222 241)
(219 237)
(212 245)
(208 236)
478
485
486
497
(465 495)
(474 495)
(463 504)
(476 516)
1,030
1,040
1,080
1,150
(981 1,090)
(998 1,090)
(1,010 1,160)
(1,110 1,190)
3,842
4,331
3,966
3,954
19992000
20012002
20032004
20052006
551
516
543
536
(523 581)
(491 543)
(513 575)
(512 561)
268
249
285
245
(259 281)
(227 271)
(264 304)
(223 257)
527
496
520
515
(509 542)
(468 535)
(504 538)
(487 554)
1,200
1,050
1,080
1,180
(1,140 1,310)
(1,010 1,120)
(994 1,210)
(1,110 1,280)
2,571
2,124
1,919
2,009
19992000
20012002
20032004
20052006
582
556
561
559
(565 599)
(542 570)
(538 585)
(540 579)
286
269
281
256
(261 304)
(250 282)
(262 294)
(231 270)
583
554
553
546
(569 603)
(544 568)
(523 584)
(528 575)
1,220
1,160
1,150
1,250
(1,150 1,270)
(1,100 1,220)
(1,090 1,310)
(1,200 1,340)
1,712
2,000
2,058
2,032
19992000
20012002
20032004
20052006
468
474
470
487
(460 476)
(462 485)
(452 489)
(470 504)
235
233
228
228
(231 240)
(227 237)
(216 244)
(217 239)
467
473
469
482
(454 478)
(460 486)
(449 488)
(462 502)
916
959
966
1,050
(890 951)
(899 1,020)
(920 1,050)
(1,010 1,100)
2,556
3,594
3,272
3,062
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
50
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
1500
1000
500
50th Percentile
1000
800
600
400
600
400
300
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
200
9900
0102
0304
0506
5th Percentile
500
Total
(3+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
1. Water-Soluble Vitamins
51
16,316
2.0
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
1,678
1,747
4,013
3,214
2,629
3,035
0.6
1.5
2.6
3.9
(0.4 1.0)
(1.2 2.0)
(1.8 3.7)
(3.1 4.9)
210,000
1,211,000
2,057,000
1,815,000
Males
Females
7,999
8,317
1.6
2.3
(1.3 2.0)
(1.9 2.9)
2,165,000
3,402,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
4,205
4,285
6,571
1.0
1.2
2.2
(0.7 1.5)
(0.8 1.8)
(1.8 2.7)
265,000
398,000
4,289,000
Gender
Race/ethnicity
(1.6 2.4)
5,563,000
52
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,524
8,390
7,837
7,694
1.9
1.8
1.6
2.4
19992000
20012002
20032004
20052006
361
439
449
444
19992000
20012002
20032004
20052006
885
1,022
843
904
19992000
20012002
20032004
20052006
2,123
2,208
2,059
1,954
0.8
0.9
0.6
0.6
(0.4 1.7)
(0.5 1.6)
(0.3 1.3)
(0.3 1.2)
251,000
276,000
214,000
209,000
19992000
20012002
20032004
20052006
1,470
1,715
1,555
1,659
2.2
1.8
1.0
2.0
(1.4 3.3)
(1.2 2.8)
(0.5 2.0)
(1.6 2.7)
1,683,000
1,436,000
805,000
1,636,000
19992000
20012002
20032004
20052006
1,198
1,478
1,276
1,353
2.4
1.8
1.9
3.3
(1.5 4.0)
(1.1 3.1)
(1.3 2.9)
(1.9 5.5)
1,708,000
1,399,000
1,508,000
2,695,000
19992000
20012002
20032004
20052006
1,487
1,528
1,655
1,380
2.7
3.6
3.9
3.9
(1.9 3.8)
(2.7 4.6)
(2.9 5.3)
(2.8 5.5)
1,159,000
1,590,000
1,806,000
1,895,000
19992000
20012002
20032004
20052006
3,682
4,059
3,871
3,740
1.7
1.3
1.3
1.9
(1.2 2.4)
(1.0 1.8)
(0.9 1.9)
(1.4 2.5)
2,113,000
1,699,000
1,727,000
2,615,000
19992000
20012002
20032004
20052006
3,842
4,331
3,966
3,954
2.1
2.2
2.0
2.8
(1.7 2.6)
(1.7 3.0)
(1.4 2.8)
(2.0 3.9)
2,824,000
3,063,000
2,787,000
4,024,000
19992000
20012002
20032004
20052006
2,571
2,124
1,919
2,009
0.8
1.8
0.7
1.5
(0.4 1.5)
(1.0 3.3)
(0.3 1.4)
(0.8 2.5)
154,000
419,000
166,000
376,000
19992000
20012002
20032004
20052006
1,712
2,000
2,058
2,032
0.7
1.6
(0.3 1.6)
(1.0 2.6)
239,000
551,000
19992000
20012002
20032004
20052006
2,556
3,594
3,272
3,062
2.1
2.0
1.9
2.6
(1.6 2.7)
(1.6 2.5)
(1.3 2.7)
(2.0 3.5)
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
(1.5 2.3)
(1.5 2.2)
(1.2 2.2)
(1.9 3.0)
4,933,000
4,762,000
4,506,000
6,642,000
3,858,000
3,733,000
3,572,000
4,978,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
1. Water-Soluble Vitamins
53
54
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
7.09
8.22
8.39
9.00
7.55
7.14
8.33
10.1
8.21
(6.95 7.23)
(8.03 8.42)
(8.22 8.57)
(8.83 9.18)
(7.36 7.74)
(7.04 7.24)
(8.17 8.50)
(9.85 10.4)
(8.06 8.37)
Geometric mean
3.91
4.42
4.65
5.64
4.12
3.93
4.84
5.79
4.48
(3.76 4.01)
(4.20 4.58)
(4.43 4.85)
(5.48 5.73)
(3.94 4.20)
(3.77 4.05)
(4.61 5.02)
(5.56 5.99)
(4.35 4.57)
2.5th
4.35
4.89
5.18
5.96
4.52
4.44
5.25
6.37
5.00
(4.20 4.50)
(4.61 5.05)
(5.03 5.34)
(5.86 6.08)
(4.40 4.69)
(4.30 4.52)
(5.15 5.36)
(6.07 6.50)
(4.85 5.12)
5th
7.02
8.00
8.21
8.68
7.30
7.09
8.13
9.79
8.04
(6.87 7.18)
(7.82 8.22)
(8.07 8.37)
(8.56 8.84)
(7.13 7.47)
(6.99 7.22)
(8.02 8.29)
(9.57 10.1)
(7.91 8.17)
50th
11.7
14.8
14.5
14.8
13.8
11.2
13.9
17.9
14.3
(11.2 12.2)
(14.4 15.7)
(14.0 15.2)
(14.2 15.6)
(13.1 14.8)
(10.9 11.6)
(13.3 14.5)
(17.1 18.9)
(13.9 15.0)
95th
12.9
18.2
17.0
18.0
16.8
12.4
16.8
21.2
(12.3 13.9)
(17.0 20.0)
(16.4 18.1)
(16.6 19.7)
(15.8 17.9)
(12.1 13.0)
(15.8 18.3)
(20.1 22.7)
(16.5 18.3)
97.5th
17.2
1,814
1,871
4,670
4,329
4,670
3,267
2,651
3,081
8,999
Sample
size
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the total U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032006.
10
Females
Males
Plasma homocysteine
(mol/L)
15
Overall
2039
60+
2039
60+
NonHispanic Whites
10
15
NonHispanic Blacks
4059
Plasma homocysteine
(mol/L)
4059
2039
60+
2039
15
Females
4059
60+
Males
10
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma homocysteine
(mol/L)
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
1. Water-Soluble Vitamins
55
Geometric mean
5th
50th
95th
Sample
size
8.21
7.14
8.33
10.1
(8.06 8.37)
(7.04 7.24)
(8.17 8.50)
(9.85 10.4)
5.00
4.44
5.25
6.37
(4.85 5.12)
(4.30 4.52)
(5.15 5.36)
(6.07 6.50)
8.04
7.09
8.13
9.79
(7.91 8.17)
(6.99 7.22)
(8.02 8.29)
(9.57 10.1)
14.3
11.2
13.9
17.9
(13.9 15.0)
(10.9 11.6)
(13.3 14.5)
(17.1 18.9)
8,999
3,267
2,651
3,081
9.00
8.05
9.21
10.6
(8.83 9.18)
(7.90 8.20)
(8.96 9.47)
(10.3 10.9)
5.96
5.65
6.28
6.89
(5.86 6.08)
(5.47 5.76)
(6.15 6.43)
(6.52 7.10)
8.68
7.94
8.86
10.4
(8.56 8.84)
(7.80 8.05)
(8.61 9.08)
(10.0 10.8)
14.8
11.9
14.3
18.0
(14.2 15.6)
(11.5 12.5)
(13.6 15.9)
(16.9 19.0)
4,329
1,473
1,306
1,550
7.55
6.33
7.58
9.72
(7.36 7.74)
(6.21 6.46)
(7.38 7.78)
(9.40 10.1)
4.52
3.96
4.90
6.02
(4.40 4.69)
(3.79 4.11)
(4.67 5.07)
(5.75 6.27)
7.30
6.31
7.30
9.43
(7.13 7.47)
(6.17 6.46)
(7.11 7.53)
(9.05 9.69)
13.8
9.87
13.0
17.8
(13.1 14.8)
(9.47 10.5)
(12.1 15.1)
(16.7 19.2)
4,670
1,794
1,345
1,531
Males
Females
Geometric mean
5th
95th
7.09
6.61
7.36
9.55
(6.95 7.23)
(6.48 6.74)
(7.21 7.52)
(9.14 9.98)
4.35
4.05
4.77
6.07
(4.20 4.50)
(3.88 4.31)
(4.38 4.92)
(5.48 6.41)
7.02
6.61
7.33
9.32
(6.87 7.18)
(6.47 6.73)
(7.20 7.47)
(8.82 9.88)
11.7
10.6
10.9
16.0
(11.2 12.2)
(9.97 11.1)
(10.5 12.3)
(15.2 18.0)
1,814
789
470
555
7.85
7.47
8.03
10.3
(7.70 8.01)
(7.30 7.64)
(7.80 8.26)
(9.78 10.8)
5.50
5.38
5.71
6.79
(5.33 5.69)
(5.05 5.59)
(4.81 6.08)
(5.75 7.27)
7.74
7.38
7.91
10.0
(7.56 7.90)
(7.15 7.68)
(7.67 8.25)
(9.44 10.5)
12.2
11.3
11.8
16.0
(11.6 12.6)
(10.9 11.9)
(10.7 13.4)
(15.1 18.4)
866
353
239
274
6.34
5.73
6.71
8.98
(6.17 6.51)
(5.57 5.91)
(6.49 6.94)
(8.49 9.49)
3.91
3.67
4.39
5.67
(3.76 4.02)
(3.41 3.82)
(3.91 4.78)
(4.83 6.08)
6.28
5.77
6.68
8.50
(6.10 6.50)
(5.57 5.99)
(6.36 6.86)
(8.07 9.07)
10.6
8.52
10.1
15.9
(10.1 11.5)
(8.11 9.49)
(9.32 12.2)
(14.2 19.8)
948
436
231
281
Males
Females
56
50th
Sample
size
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
5th
50th
95th
Sample
size
8.22
7.14
8.55
10.7
(8.03 8.42)
(6.95 7.34)
(8.31 8.79)
(10.4 11.0)
4.89
4.46
5.28
6.45
(4.61 5.05)
(4.20 4.61)
(5.10 5.39)
(6.00 6.95)
8.00
7.14
8.42
10.3
(7.82 8.22)
(6.98 7.36)
(8.14 8.70)
(10.1 10.7)
14.8
11.2
14.7
20.7
(14.4 15.7)
(10.8 11.8)
(13.9 17.1)
(18.8 23.6)
1,871
720
626
525
9.09
8.19
9.40
11.1
(8.91 9.27)
(7.95 8.44)
(9.12 9.70)
(10.7 11.6)
5.93
5.72
6.17
6.76
(5.73 6.16)
(5.42 5.88)
(5.70 6.41)
(6.39 7.30)
8.78
8.04
9.11
10.9
(8.58 8.96)
(7.80 8.25)
(8.82 9.41)
(10.3 11.3)
15.3
12.1
15.3
21.1
(14.5 16.4)
(11.6 13.1)
(14.2 18.2)
(17.5 24.9)
896
340
292
264
7.59
6.38
7.90
10.4
(7.34 7.85)
(6.19 6.58)
(7.56 8.25)
(9.98 10.9)
4.52
4.19
4.98
6.15
(4.23 4.74)
(3.80 4.38)
(4.46 5.23)
(5.74 6.83)
7.23
6.43
7.73
9.93
(7.07 7.53)
(6.25 6.72)
(7.22 8.08)
(9.50 10.5)
14.7
9.79
13.7
20.7
(13.5 15.9)
(9.22 10.6)
(11.9 16.1)
(18.7 24.7)
975
380
334
261
Males
Females
Geometric mean
5th
50th
95th
Sample
size
8.39
7.26
8.40
10.1
(8.22 8.57)
(7.13 7.40)
(8.21 8.60)
(9.82 10.4)
5.18
4.51
5.36
6.38
(5.03 5.34)
(4.33 4.79)
(5.19 5.51)
(6.09 6.59)
8.21
7.26
8.24
9.82
(8.07 8.37)
(7.07 7.39)
(8.09 8.44)
(9.57 10.1)
14.5
11.2
13.6
17.6
(14.0 15.2)
(10.9 11.9)
(13.1 14.9)
(16.7 18.4)
4,670
1,458
1,353
1,859
9.15
8.11
9.28
10.6
(8.94 9.36)
(7.91 8.32)
(8.98 9.59)
(10.3 10.9)
6.13
5.69
6.35
6.95
(5.95 6.24)
(5.47 5.85)
(6.21 6.55)
(6.65 7.15)
8.80
8.00
8.89
10.4
(8.61 8.99)
(7.85 8.14)
(8.61 9.16)
(10.0 10.8)
14.9
11.8
14.2
17.8
(14.2 16.0)
(11.2 12.7)
(13.4 16.0)
(16.6 19.0)
2,274
641
687
946
7.75
6.50
7.63
9.69
(7.54 7.96)
(6.35 6.65)
(7.40 7.87)
(9.34 10.0)
4.72
3.98
4.99
6.03
(4.49 4.93)
(3.77 4.13)
(4.70 5.18)
(5.71 6.28)
7.53
6.46
7.38
9.48
(7.34 7.70)
(6.29 6.59)
(7.16 7.62)
(9.05 9.73)
14.0
10.2
13.0
17.1
(13.3 15.2)
(9.55 11.0)
(11.8 15.8)
(16.3 18.7)
2,396
817
666
913
Males
Females
1. Water-Soluble Vitamins
57
8.07
8.21
8.56
7.88
(7.95 8.18)
(8.04 8.38)
(8.32 8.81)
(7.73 8.04)
4.82
5.01
5.31
4.78
(4.65 5.02)
(4.86 5.15)
(5.15 5.40)
(4.60 4.94)
7.94
8.01
8.33
7.76
(7.82 8.04)
(7.84 8.17)
(8.14 8.55)
(7.60 7.90)
14.3
14.4
14.9
13.7
(13.5 15.0)
(13.9 15.1)
(14.2 15.9)
(13.1 14.5)
4,192
4,759
4,509
4,490
19992000
20012002
20032004
4.21
4.31
4.36
(4.05 4.39)
(4.16 4.46)
(4.18 4.55)
2.81
2.95
3.10
(2.56 2.98)
(2.65 3.21)
(2.87 3.19)
4.19
4.28
4.42
(4.02 4.42)
(4.20 4.44)
(4.14 4.65)
6.31
6.15
6.28
(5.75 7.70)
(5.89 6.50)
(5.72 6.66)
376
454
454
19992000
20012002
20032004
4.35
4.67
4.65
(4.18 4.54)
(4.58 4.77)
(4.53 4.78)
2.91
3.27
3.22
(2.55 3.09)
(3.04 3.44)
(2.99 3.37)
4.36
4.61
4.68
(4.20 4.50)
(4.53 4.73)
(4.51 4.82)
6.49
6.94
6.62
(6.21 6.78)
(6.60 7.21)
(6.44 6.77)
899
1,034
852
19992000
20012002
20032004
5.87
6.03
6.30
(5.70 6.05)
(5.88 6.19)
(6.14 6.47)
3.65
3.96
4.26
(3.37 3.81)
(3.64 4.14)
(4.08 4.36)
5.83
5.90
6.21
(5.70 6.01)
(5.73 6.11)
(6.02 6.43)
9.58
9.48
10.0
(9.23 10.6)
(9.30 10.1)
(9.43 10.7)
2,132
2,225
2,073
19992000
20012002
20032004
20052006
7.19
7.27
7.47
6.81
(7.04 7.35)
(7.12 7.42)
(7.33 7.62)
(6.67 6.95)
4.23
4.42
4.71
4.21
(4.06 4.42)
(4.21 4.67)
(4.47 4.99)
(3.99 4.42)
7.26
7.16
7.42
6.72
(7.03 7.43)
(7.08 7.25)
(7.30 7.58)
(6.61 6.84)
11.9
12.0
11.3
11.0
(11.3 12.5)
(11.6 12.8)
(11.0 12.0)
(10.4 11.5)
1,474
1,720
1,561
1,706
19992000
20012002
20032004
20052006
8.27
8.30
8.67
8.01
(8.07 8.48)
(8.17 8.43)
(8.42 8.93)
(7.84 8.18)
5.18
5.35
5.60
5.13
(5.05 5.27)
(5.16 5.48)
(5.33 5.74)
(4.82 5.25)
8.08
8.17
8.44
7.90
(7.94 8.26)
(8.02 8.31)
(8.20 8.61)
(7.70 8.07)
13.5
13.4
14.4
12.8
(12.4 15.6)
(12.7 14.1)
(13.6 16.2)
(12.5 14.1)
1,209
1,494
1,280
1,371
19992000
20012002
20032004
20052006
9.78
10.2
10.6
9.69
(9.53 10.0)
(9.76 10.6)
(10.2 10.9)
(9.36 10.0)
6.10
6.36
6.62
6.01
(6.03 6.17)
(6.12 6.64)
(6.33 6.99)
(5.75 6.29)
9.45
9.79
10.3
9.40
(9.23 9.75)
(9.33 10.2)
(9.93 10.6)
(9.05 9.75)
17.6
18.6
19.0
17.5
(16.9 18.7)
(17.7 19.6)
(17.6 20.2)
(16.2 18.5)
1,509
1,545
1,668
1,413
19992000
20012002
20032004
20052006
8.90
9.06
9.35
8.67
(8.69 9.11)
(8.89 9.23)
(9.06 9.65)
(8.49 8.84)
5.77
6.08
6.28
5.82
(5.57 5.92)
(5.86 6.24)
(6.09 6.42)
(5.70 5.92)
8.65
8.74
8.92
8.42
(8.42 8.92)
(8.53 8.96)
(8.67 9.17)
(8.25 8.59)
15.0
14.9
15.3
14.2
(14.2 16.6)
(14.3 15.8)
(14.5 16.7)
(13.2 15.2)
1,959
2,255
2,177
2,152
19992000
20012002
20032004
20052006
7.37
7.50
7.89
7.22
(7.23 7.52)
(7.32 7.68)
(7.61 8.18)
(7.00 7.45)
4.31
4.53
4.86
4.40
(4.07 4.53)
(4.32 4.73)
(4.51 5.03)
(4.19 4.51)
7.30
7.23
7.60
6.98
(7.14 7.42)
(7.06 7.36)
(7.39 7.87)
(6.80 7.15)
13.1
13.6
14.3
13.1
(12.7 14.3)
(12.9 14.8)
(13.4 15.8)
(12.1 14.9)
2,233
2,504
2,332
2,338
19992000
20012002
20032004
20052006
7.28
7.18
7.30
6.90
(7.06 7.50)
(6.85 7.53)
(7.11 7.49)
(6.74 7.05)
4.22
4.27
4.49
4.31
(3.96 4.58)
(4.00 4.47)
(4.25 4.57)
(3.99 4.44)
7.08
7.10
7.31
6.75
(6.88 7.36)
(6.80 7.34)
(7.17 7.42)
(6.62 6.94)
12.5
12.4
11.9
11.2
(11.8 13.9)
(11.8 13.7)
(11.3 12.7)
(10.8 12.2)
1,146
1,009
904
910
19992000
20012002
20032004
20052006
8.14
8.29
8.53
7.94
(7.87 8.41)
(8.03 8.55)
(8.24 8.83)
(7.72 8.17)
4.71
4.64
5.04
4.73
(4.25 4.87)
(4.40 5.08)
(4.84 5.24)
(4.50 4.90)
7.91
7.93
8.29
7.74
(7.51 8.34)
(7.72 8.17)
(7.99 8.59)
(7.50 7.95)
15.3
15.4
14.9
14.7
(14.7 16.6)
(14.4 17.9)
(14.4 16.6)
(14.0 15.5)
773
872
869
1,002
8.19
8.37
8.74
8.06
(8.07 8.30)
(8.21 8.54)
(8.50 8.99)
(7.89 8.24)
5.09
5.18
5.46
4.97
(4.82 5.19)
(5.04 5.26)
(5.37 5.57)
(4.70 5.15)
8.03
8.14
8.53
7.94
(7.93 8.22)
(7.98 8.28)
(8.29 8.72)
(7.83 8.04)
14.3
14.6
15.1
13.9
(13.5 14.8)
(14.0 15.7)
(14.2 16.1)
(13.2 14.8)
1,874
2,514
2,406
2,264
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
(20 years and older)
Males
Females
Race/ethnicity
(20 years and older)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
19992000
20012002
20032004
20052006
58
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
20
15
10
50th Percentile
10
4
7
5
4
3
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
2
9900
0102
0304
0506
5th Percentile
Total
(20+y)
15y
611y
1219y
20+y
Males
(20+y)
Females
(20+y)
MA
(20+y)
NHB
(20+y)
NHW
(20+y)
59
8,999
7.7
2039 years
4059 years
60 years and older
3,267
2,651
3,081
1.9
7.0
18.5
(1.4 2.4)
(5.6 8.7)
(16.3 21.0)
1,482,000
5,553,000
8,620,000
Males
Females
4,329
4,670
9.2
6.4
(7.9 10.6)
(5.2 7.7)
9,021,000
6,796,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
1,814
1,871
4,670
2.1
8.9
8.3
(1.5 2.9)
(7.7 10.2)
(7.1 9.6)
336,000
2,005,000
12,066,000
Gender
Race/ethnicity
60
(6.8 8.8)
15,825,000
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
4,192
4,759
4,509
4,490
6.9
7.8
9.5
6.0
19992000
20012002
20032004
376
454
454
19992000
20012002
20032004
899
1,034
852
19992000
20012002
20032004
2,132
2,225
2,073
1.5
0.9
1.1
(0.8 2.8)
(0.5 1.6)
(0.5 2.1)
19992000
20012002
20032004
20052006
1,474
1,720
1,561
1,706
2.6
3.2
2.4
1.3
(1.6 4.3)
(2.2 4.6)
(1.7 3.4)
(0.8 2.2)
2,058,000
2,505,000
1,923,000
1,034,000
19992000
20012002
20032004
20052006
1,209
1,494
1,280
1,371
5.9
5.8
9.4
4.7
(4.3 8.1)
(4.4 7.5)
(7.0 12.4)
(3.6 6.2)
4,188,000
4,378,000
7,396,000
3,894,000
19992000
20012002
20032004
20052006
1,509
1,545
1,668
1,413
17.3
20.5
21.6
15.6
(14.8 20.3)
(17.1 24.5)
(19.2 24.2)
(12.3 19.5)
7,441,000
9,180,000
10,039,000
7,527,000
19992000
20012002
20032004
20052006
1,959
2,255
2,177
2,152
8.6
9.6
11.4
7.0
(7.0 10.4)
(7.8 11.7)
(9.4 13.7)
(5.6 8.7)
7,854,000
9,136,000
11,197,000
7,036,000
19992000
20012002
20032004
20052006
2,233
2,504
2,332
2,338
5.4
6.1
7.7
5.1
(4.5 6.6)
(4.9 7.5)
(6.0 9.8)
(3.8 6.8)
5,459,000
6,342,000
8,202,000
5,525,000
19992000
20012002
20032004
20052006
1,146
1,009
904
910
4.4
3.8
2.7
1.6
(3.3 5.9)
(2.5 5.5)
(1.8 4.0)
(1.0 2.5)
542,000
542,000
426,000
263,000
19992000
20012002
20032004
20052006
773
872
869
1,002
8.6
9.6
10.8
7.0
(6.7 10.8)
(7.8 11.8)
(8.7 13.2)
(6.0 8.2)
1,872,000
2,120,000
2,435,000
1,640,000
19992000
20012002
20032004
20052006
1,874
2,514
2,406
2,264
7.0
8.4
10.1
6.5
(6.0 8.1)
(6.9 10.3)
(8.3 12.2)
(5.4 7.7)
9,938,000
12,142,000
14,718,000
9,541,000
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
(20 years and older)
Males
Females
Race/ethnicity
(20 years and older)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
(6.0 8.1)
(6.5 9.2)
(7.9 11.3)
(5.1 6.9)
13,319,000
15,479,000
19,421,000
12,553,000
466,000
294,000
358,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
1. Water-Soluble Vitamins
61
62
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
111
109
143
136
131
120
117
118
122
137
177
134
(108 114)
(104 114)
(136 150)
(130 142)
(125 138)
(110 130)
(111 123)
(115 122)
(116 127)
(129 144)
(169 186)
(128 140)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
35 years
611 years
1219 years
2039 years
4059 years
60 years and older
Geometric mean
56.2
55.3
69.4
65.0
61.3
61.1
60.6
62.4
61.4
62.9
79.7
63.2
(53.3 58.0)
(52.3 57.9)
(65.1 72.9)
(63.0 67.9)
(58.2 63.9)
(54.6 63.4)
(56.9 64.4)
(56.8 64.4)
(57.0 64.4)
(59.2 67.8)
(73.5 83.6)
(60.5 65.6)
2.5th
61.9
61.1
76.9
72.4
68.1
65.2
67.5
67.3
67.3
70.9
89.9
70.0
(58.6 64.4)
(57.7 64.1)
(73.1 79.9)
(69.4 75.4)
(65.2 71.3)
(56.6 72.1)
(61.0 72.6)
(64.8 70.0)
(64.2 69.6)
(66.6 75.0)
(83.6 94.5)
(67.3 72.8)
5th
106
105
135
127
126
117
113
115
116
130
163
127
(100 112)
(99.3 111)
(129 141)
(123 132)
(120 132)
(109 124)
(109 118)
(110 118)
(110 123)
(124 138)
(156 170)
(122 132)
50th
230
224
308
299
287
269
228
222
246
275
429
293
(209 254)
(206 246)
(283 340)
(277 339)
(272 315)
(235 307)
(204 253)
(210 263)
(231 275)
(252 338)
(392 482)
(277 320)
95th
300
270
393
406
362
299
258
280
303
387
628
(248 387)
(249 298)
(360 480)
(364 526)
(328 403)
(271 516)
(229 461)
(247 326)
(279 368)
(324 572)
(536 822)
(359 428)
97.5th
387
1,834
1,993
3,152
3,719
3,825
421
806
1,979
1,496
1,230
1,612
7,544
Sample
size
Geometric mean and selected percentiles of plasma concentrations (in nmol/L) for the total U.S. population aged 3 years and older, National
Health and Nutrition Examination Survey, 20032004.
200
Mexican Americans
50
100
150
Females
Males
Overall
35
611
1219
2039
4059
60+
35
611
4059
60+
4059
60+
50
100
150
200
NonHispanic Whites
35
611
1219
2039
4059
60+
35
611
1219
2039
Males
200
Females
50
100
150
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
2039
NonHispanic Blacks
1219
35
611
1219
2039
Age (years)
4059
60+
35
611
1219
2039
4059
60+
Age (years)
1. Water-Soluble Vitamins
63
Geometric mean
10th
50th
90th
Sample
size
134
120
117
118
122
137
177
(128 140)
(110 130)
(111 123)
(115 122)
(116 127)
(129 144)
(169 186)
79.6
74.5
77.6
75.1
75.5
82.3
102
(76.4 82.4)
(67.8 79.0)
(72.5 79.9)
(72.5 78.2)
(71.7 79.2)
(77.2 86.3)
(96.8 106)
127
117
113
115
116
130
163
(122 132)
(109 124)
(109 118)
(110 118)
(110 123)
(124 138)
(156 170)
231
198
184
189
201
223
328
(218 249)
(169 269)
(168 205)
(179 201)
(188 219)
(209 238)
(312 358)
7,544
421
806
1,979
1,496
1,230
1,612
136
122
117
123
126
141
178
(130 142)
(110 135)
(109 126)
(118 129)
(120 133)
(132 151)
(168 189)
82.8
71.6
75.9
79.2
78.7
86.2
99.0
(79.4 85.3)
(65.1 78.7)
(69.5 79.4)
(76.7 81.4)
(72.6 85.9)
(79.9 93.2)
(93.0 103)
127
118
112
119
119
134
162
(123 132)
(103 129)
(107 119)
(112 125)
(111 125)
(128 141)
(155 174)
231
239
191
197
209
224
351
(217 253)
(180 272)
(167 223)
(179 210)
(194 223)
(206 266)
(328 373)
3,719
223
385
1,016
705
608
782
131
117
116
113
117
132
177
(125 138)
(107 127)
(111 122)
(110 116)
(112 123)
(123 142)
(165 189)
77.5
75.5
78.7
71.4
73.0
79.0
106
(73.7 81.0)
(65.7 79.7)
(73.9 81.4)
(67.8 74.1)
(68.4 76.5)
(71.2 85.3)
(97.3 111)
126
117
115
109
113
126
164
(120 132)
(109 122)
(109 119)
(106 113)
(106 120)
(119 136)
(155 170)
231
169
177
181
197
222
315
(217 250)
(155 276)
(164 207)
(171 203)
(180 218)
(208 236)
(291 357)
3,825
198
421
963
791
622
830
Males
Females
Geometric mean
10th
50th
90th
Sample
size
111
107
105
107
108
115
152
(108 114)
(94.2 122)
(96.7 113)
(102 112)
(99.2 117)
(110 119)
(138 168)
69.4
74.1
70.8
65.8
67.7
71.7
87.6
(67.1 72.4)
(65.1 76.9)
(61.5 77.1)
(62.4 69.8)
(65.0 70.6)
(65.4 75.8)
(81.1 92.8)
106
106
101
104
103
108
138
(100 112)
(87.8 118)
(92.6 112)
(98.3 109)
(92.6 116)
(102 115)
(125 159)
186
150
152
167
181
201
272
(174 201)
(133 279)
(142 192)
(160 184)
(156 242)
(178 220)
(245 368)
1,834
111
258
599
322
216
328
116
108
104
118
113
123
153
(114 119)
(93.9 124)
(96.1 113)
(111 126)
(104 124)
(114 133)
(130 181)
74.3
72.6
70.2
72.9
75.6
73.4
89.1
(69.8 77.3)
(57.0 81.5)
(50.9 79.4)
(67.6 78.7)
(64.0 81.1)
(65.2 76.6)
(80.1 95.3)
109
105
105
111
106
116
137
(106 114)
(87.6 119)
(90.5 113)
(104 119)
(99.5 113)
(103 131)
(119 158)
199
145
148
198
189
218
268
(185 217)
(131 307)
(138 232)
(171 242)
(157 363)
(173 330)
(234 411)
911
59
124
306
149
113
160
105
106
105
96.2
102
106
151
(99.3 112)
(87.6 128)
(94.3 117)
(91.3 101)
(91.2 113)
(95.2 117)
(135 170)
67.0
74.1
72.4
61.6
65.4
69.8
83.4
(61.7 68.7)
(57.0 81.0)
(58.9 77.7)
(55.1 66.5)
(56.5 68.0)
(58.0 75.4)
(77.3 96.5)
102
105
99.7
95.5
99.5
101
140
(92.6 110)
(80.4 127)
(89.6 115)
(90.0 102)
(81.5 119)
(95.6 109)
(120 171)
176
152
160
150
170
181
279
(157 201)
(124 228)
(145 218)
(142 156)
(147 208)
(137 247)
(243 333)
923
52
134
293
173
103
168
Males
Females
64
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
109
95.4
98.7
96.0
102
117
148
(104 114)
(87.4 104)
(92.9 105)
(90.6 102)
(96.5 108)
(108 126)
(137 159)
68.4
62.7
65.9
63.9
66.7
74.1
91.8
112
95.4
99.0
102
107
122
145
(107 117)
(87.4 104)
(90.5 108)
(95.5 109)
(99.9 114)
(110 136)
(133 158)
107
95.4
98.4
90.3
98.5
113
150
(100 114)
(84.0 108)
(92.6 105)
(84.7 96.2)
(91.3 106)
(104 123)
(137 163)
Males
Females
50th
90th
Sample
size
(65.1 71.0)
(54.6 72.2)
(56.1 71.0)
(60.0 66.4)
(56.2 70.0)
(63.5 78.1)
(76.6 105)
105
99.4
96.6
93.2
99.3
114
142
(99.3 111)
(86.5 106)
(92.1 103)
(89.7 97.7)
(91.3 107)
(99.8 122)
(131 147)
177
139
147
147
161
193
245
(167 188)
(125 159)
(139 159)
(135 160)
(151 177)
(161 246)
(217 299)
1,993
146
290
721
328
275
233
69.6
65.2
64.3
69.5
69.3
71.5
85.0
(67.8 72.6)
(< LOD 73.4)
(50.7 69.3)
(64.4 72.8)
(64.1 72.9)
(61.4 77.4)
(77.2 98.7)
108
101
97.4
97.9
102
117
138
(101 113)
(87.6 107)
(86.2 109)
(92.3 103)
(97.0 114)
(104 124)
(125 150)
184
125
150
154
157
226
237
(171 199)
(121 140)
(138 177)
(143 179)
(149 182)
(179 280)
(212 322)
992
76
135
381
161
130
109
66.9
59.3
68.7
59.4
64.5
75.0
96.5
(62.2 70.8)
(< LOD 71.8)
(57.1 74.3)
(56.1 64.1)
(52.6 68.2)
(62.0 82.2)
(72.9 107)
104
95.6
95.9
89.6
92.9
110
143
(95.7 110)
(80.0 108)
(89.5 105)
(85.8 94.5)
(85.7 101)
(97.7 120)
(129 152)
172
141
145
139
162
169
247
(161 187)
(126 268)
(135 155)
(128 151)
(142 197)
(151 211)
(216 334)
1,001
70
155
340
167
145
124
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
Geometric mean
10th
50th
90th
Sample
size
143
133
130
128
128
142
182
(136 150)
(123 145)
(122 139)
(122 133)
(121 136)
(134 152)
(173 192)
86.7
80.5
87.3
79.9
82.7
86.6
105
(82.8 89.9)
(64.1 94.6)
(77.5 95.7)
(77.7 83.3)
(76.3 87.1)
(80.6 92.9)
(99.1 109)
135
128
122
122
123
136
167
(129 141)
(119 140)
(114 135)
(119 127)
(115 132)
(128 145)
(161 176)
242
246
213
203
204
227
341
(229 266)
(200 274)
(189 232)
(188 217)
(194 228)
(210 258)
(316 365)
3,152
115
196
525
708
642
966
144
139
132
131
130
145
182
(137 152)
(121 160)
(120 146)
(122 141)
(120 141)
(135 157)
(171 195)
91.0
73.7
91.6
83.4
88.1
95.7
101
(85.8 94.2)
(63.0 99.4)
(72.1 101)
(78.2 89.6)
(69.7 93.3)
(82.6 99.6)
(95.8 104)
134
130
120
125
123
138
168
(127 142)
(118 155)
(111 141)
(119 133)
(113 137)
(130 145)
(159 187)
240
267
207
204
205
224
364
(224 274)
(242 279)
(184 266)
(179 256)
(186 231)
(203 275)
(330 390)
1,535
62
91
266
319
321
476
141
126
128
124
126
140
183
(135 148)
(113 141)
(121 136)
(119 129)
(119 133)
(128 152)
(170 196)
84.1
80.7
86.5
77.6
80.0
82.8
109
(79.2 88.1)
(54.0 103)
(71.3 92.4)
(73.9 80.2)
(75.3 84.5)
(71.4 90.2)
(103 116)
135
122
122
119
121
135
166
(129 141)
(113 140)
(116 129)
(115 127)
(114 132)
(122 147)
(161 175)
246
168
209
202
203
231
318
(231 261)
(151 311)
(170 251)
(179 231)
(187 239)
(219 259)
(299 360)
1,617
53
105
259
389
321
490
Males
Females
1. Water-Soluble Vitamins
65
132
130
134
(129 136)
(126 133)
(128 140)
64.9
63.8
70.0
(62.8 67.0)
(61.3 66.4)
(67.3 72.8)
123
119
127
(119 126)
(116 123)
(122 132)
280
276
293
(266 298)
(263 293)
(277 320)
7,597
8,451
7,544
19992000
20012002
20032004
124
116
120
(118 131)
(112 121)
(110 130)
67.4
63.9
65.2
(61.8 71.6)
(61.8 66.0)
(56.6 72.1)
116
108
117
(111 122)
(104 113)
(109 124)
237
219
269
(197 332)
(195 244)
(235 307)
376
453
421
19992000
20012002
20032004
125
118
117
(117 134)
(114 122)
(111 123)
66.9
62.6
67.5
(63.5 70.3)
(57.7 66.8)
(61.0 72.6)
117
113
113
(107 130)
(109 118)
(109 118)
210
200
228
(191 319)
(187 224)
(204 253)
898
1,031
806
19992000
20012002
20032004
118
115
118
(112 125)
(112 119)
(115 122)
60.2
56.9
67.3
(55.1 63.5)
(54.6 59.1)
(64.8 70.0)
109
107
115
(103 117)
(104 110)
(110 118)
231
228
222
(206 291)
(216 264)
(210 263)
2,132
2,220
1,979
19992000
20012002
20032004
124
121
122
(119 129)
(116 125)
(116 127)
62.4
59.5
67.3
(59.7 64.9)
(55.9 61.8)
(64.2 69.6)
116
112
116
(110 121)
(107 117)
(110 123)
259
239
246
(235 295)
(226 268)
(231 275)
1,474
1,715
1,496
19992000
20012002
20032004
133
131
137
(130 137)
(127 135)
(129 144)
65.4
71.2
70.9
(62.6 68.1)
(66.4 73.4)
(66.6 75.0)
124
120
130
(122 127)
(117 124)
(124 138)
251
264
275
(239 277)
(231 302)
(252 338)
1,210
1,491
1,230
19992000
20012002
20032004
168
172
177
(163 174)
(164 180)
(169 186)
80.3
76.9
89.9
(67.7 89.1)
(74.1 79.8)
(83.6 94.5)
149
156
163
(145 155)
(150 162)
(156 170)
423
487
429
(392 458)
(413 604)
(392 482)
1,507
1,541
1,612
19992000
20012002
20032004
136
133
136
(132 141)
(129 138)
(130 142)
67.2
66.4
72.4
(64.5 70.0)
(62.7 70.1)
(69.4 75.4)
127
123
127
(123 131)
(120 127)
(123 132)
288
273
299
(265 309)
(258 294)
(277 339)
3,708
4,091
3,719
19992000
20012002
20032004
128
126
131
(124 132)
(123 130)
(125 138)
63.3
62.3
68.1
(61.1 65.5)
(59.9 64.7)
(65.2 71.3)
118
115
126
(114 122)
(111 119)
(120 132)
276
277
287
(262 294)
(261 301)
(272 315)
3,889
4,360
3,825
19992000
20012002
20032004
110
111
111
(106 114)
(107 115)
(108 114)
56.2
53.7
61.9
(54.9 57.5)
(51.0 56.5)
(58.6 64.4)
100
103
106
(97.3 103)
(99.0 108)
(100 112)
225
225
230
(198 270)
(218 235)
(209 254)
2,595
2,131
1,834
19992000
20012002
20032004
108
112
109
(103 113)
(108 116)
(104 114)
57.5
55.6
61.1
(52.6 60.7)
(53.0 58.2)
(57.7 64.1)
98.3
102
105
(91.5 105)
(98.3 107)
(99.3 111)
217
220
224
(192 250)
(200 258)
(206 246)
1,732
2,036
1,993
140
137
143
(136 144)
(133 141)
(136 150)
72.0
70.6
76.9
(69.8 74.2)
(66.8 72.7)
(73.1 79.9)
131
126
135
(126 135)
(122 130)
(129 141)
290
288
308
(272 311)
(272 304)
(283 340)
2,573
3,605
3,152
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
19992000
20012002
20032004
66
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
300
250
200
150
160
50th Percentile
140
120
100
80
70
60
9900
0102
0304
9900
0102
0304
9900
0102
0304
611y
1219y
20+y
Males
Females
MA
NHB
1. Water-Soluble Vitamins
9900
0102
0304
9900
0102
0304
35y
9900
0102
0304
9900
0102
0304
Total
(3+y)
9900
0102
0304
9900
0102
0304
50
9900
0102
0304
5th Percentile
80
NHW
67
7,544
6.5
(5.3 7.9)
35 years
611 years
1219 years
2039 years
4059 years
60 years and older
421
806
1,979
1,496
1,230
1,612
4.5
3.2
3.8
5.8
16.7
(2.0 9.7)
Males
Females
3,719
3,825
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
1,834
1,993
3,152
Gender
Race/ethnicity
18,411,000
(2.2 4.6)
(2.9 5.1)
(4.1 8.1)
(13.7 20.1)
916,000
1,054,000
3,066,000
4,557,000
7,748,000
6.8
6.2
(5.4 8.6)
(5.0 7.7)
9,439,000
8,965,000
2.8
2.5
7.6
(1.7 4.4)
(1.8 3.4)
(6.1 9.4)
722,000
846,000
14,546,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
68
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,597
8,451
7,544
5.5
5.3
6.5
19992000
20012002
20032004
376
453
421
4.5
19992000
20012002
20032004
898
1,031
806
2.5
1.5
(1.1 5.6)
(0.7 3.0)
19992000
20012002
20032004
2,132
2,220
1,979
3.3
3.3
3.2
(2.1 5.3)
(2.1 5.3)
(2.2 4.6)
1,061,000
1,079,000
1,054,000
19992000
20012002
20032004
1,474
1,715
1,496
4.5
3.7
3.8
(3.2 6.1)
(2.6 5.0)
(2.9 5.1)
3,496,000
2,888,000
3,066,000
19992000
20012002
20032004
1,210
1,491
1,230
4.0
4.7
5.8
(3.0 5.2)
(3.6 6.1)
(4.1 8.1)
2,803,000
3,557,000
4,557,000
19992000
20012002
20032004
1,507
1,541
1,612
13.9
13.9
16.7
(11.7 16.6)
(12.0 16.1)
(13.7 20.1)
5,986,000
6,225,000
7,748,000
19992000
20012002
20032004
3,708
4,091
3,719
5.7
5.1
6.8
(4.7 6.9)
(4.3 6.0)
(5.4 8.6)
7,231,000
6,671,000
9,157,000
19992000
20012002
20032004
3,889
4,360
3,825
5.3
5.5
6.2
(4.5 6.3)
(4.6 6.5)
(5.0 7.7)
7,133,000
7,546,000
8,723,000
19992000
20012002
20032004
2,595
2,131
1,834
3.2
2.9
2.8
(2.0 5.0)
(2.2 3.8)
(1.7 4.4)
632,000
656,000
687,000
19992000
20012002
20032004
1,732
2,036
1,993
2.5
2.6
2.5
(1.6 3.7)
(1.7 3.9)
(1.8 3.4)
803,000
842,000
817,000
19992000
20012002
20032004
2,573
3,605
3,152
6.1
5.9
7.6
(5.3 7.1)
(5.2 6.8)
(6.1 9.4)
11,346,000
11,036,000
14,198,000
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
(4.8 6.3)
(4.6 6.0)
(5.3 7.9)
(2.0 9.7)
14,367,000
14,218,000
17,887,000
553,000
623,000
372,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
1. Water-Soluble Vitamins
69
References
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methylmalonic acid and total homocysteine concentrations. Am J Hematol. 1990;34:9098.
Baik HW, Russel RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19:357377.
Bailey RL, Carmel R, Green R, Pfeiffer CM, Cogswell ME, Osterloh JD, et al. Monitoring of vitamin B-12
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Nutr. 2011;94:552-561.
Carmel R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of
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Fat- and Water-Soluble Vitamins. New York: John Wiley & Sons, Inc.; 2000. pp. 291311.
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supplementation. N Engl J Med. 1992;327:18321835.
de Benoist B. Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies. Food Nutr
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Gunter EW, Bowman BA, Caudill SP, Twite DB, Adams MJ, Sampson EJ. Results of an international round robin
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Halsted CH. Intestinal absorption of dietary folates. In: Picciano MF, Stokstad ELR, Gregory JF, editors. Folic acid
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Hamner HC, Cogswell ME, Johnson MA. Acculturation factors are associated with folate intakes among Mexican
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B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, D.C.: National Academy Press; 1998.
Institute of Medicine, Food and Nutrition Board. Applications in dietary assessment. Washington, D.C.: National
Academy Press; 2000.
Jacques PF, Selhub J, Bostom AG, Wilson PF, Rosenberg IH. The effect of folic acid fortification on plasma folate
and total homocysteine concentrations. N Engl J Med. 1999;340:14491454.
Life Sciences Research Office, Center for Food Safety and Applied Nutrition. Assessment of the folate nutritional
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Life Sciences Research Office, Center for Food Safety and Applied Nutrition. Assessment of folate methodology
used in the Third National Health and Nutrition Survey (NHANES 19881994). Washington, D.C.: U.S. Food
and Drug Administration, Department of Health and Human Services; 1994.
Midttun O, Hustad S, Solheim E, Schneeded J, Ueland PM. Multianalyte quantification of vitamin B6 and B2
species in the nanomolar range in human plasma by liquid chromatography-tandem mass spectrometry. Clin
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MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council
Vitamin Study. Lancet. 1991;338:131137.
Pedersen TL, Keyes WR, Shahab-Ferdows S, Allen LH, Newman JW. Methylmalonic acid quantification in low
serum volumes by UPLCMS/MS. J Chrom B. 2011;879:15021506.
Pfeiffer CM, Johnson CL, Jain RB, Yetley EA, Picciano MF, Rader JI, et al. Trends in blood folate and vitamin B12
concentrations in the United States, 19882004. Am J Clin Nutr. 2007;86:718727.
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2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Pfeiffer CM, Osterloh JD, Kennedy-Stephenson J, Picciano MF, Yetley EA, Rader JI, et al. Trends in circulating
concentrations of total homocysteine among US adolescents and adults: findings from the 19911994 and
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Pfeiffer CM, Fazili Z, Zhang M. Folate analytical methodology. In: Bailey LB, editor. Folate in Health and Disease.
2nd ed. Boca Raton: CRC Press, Taylor & Francis Group; 2010. pp. 517574.
Rasmussen K, Vyberg B, Pedersen KO, Brochner-Mortensen J. Methylmalonic acid in renal insufficiency: Evidence
of accumulation and implications for diagnosis of cobalamin deficiency. Clin Chem. 1990;36:15231524.
Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, et al. Facts and recommendations about total
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Rybak ME, Pfeiffer CM. Clinical analysis of vitamin B6: Determination of pyridoxal 5-phosphate and 4-pyridoxic
acid in human serum by reversed-phase high-performance liquid chromatography with chlorite postcolumn
derivatization. Anal Biochem. 2004;333:336344.
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5-phosphate measurements in serum. Clin Chem. 2005;51:12231231.
Rybak ME, Pfeiffer CM. A simplified protein precipitation and filtration procedure for determining serum vitamin
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Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of
homocysteinemia in an elderly population. JAMA. 1993;270:26932698.
Senti FR, Pilch SM. Analysis of folate data from the Second National Health and Nutrition Examination Survey
(NHANES II). J Nutr. 1985;115:13981402.
Shane B. Folate status assessment history: implications for measurement of biomarkers in NHANES. Am J Clin
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of cases of spina bifida and other neural tube defects. Morb Mort Wkly Rep. 1992;41(No. RR-14):001.
U.S. Centers for Disease Control and Prevention. CDC Grand Rounds: Additional opportunities to prevent neural
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th
Americans, 2010. 7 Edition, Washington, DC: U.S. Government Printing Office, December 2010. [cited 2011].
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products to require addition of folic acid. Final rule. Fed Regist. 1996;61(44):87818797.
Williams LJ, Rasmussen SA, Flores A, Kirby RS, Edmonds LD. Decline in the prevalence of spina bifida and
anencephaly by race/ethnicity: 19952002. Pediatrics. 2005;116:580586.
Wollensen F, Brattstrom L, Refsum H, Ueland PM, Berglund L, Berne C. Plasma total homocysteine and cysteine
in relation to glomerular filtration rate in diabetes mellitus. Kidney Int. 1999;55:10281035.
Wright JD, Bialostosky K, Gunter EW, Carroll MD, Najjar MF, Bowman BA, et al. Blood folate and vitamin B12:
United States, 19881994. National Center for Health Statistics. Vital Health Stat Series No. 11(243), 1998.
Yang Q, Botto LD, Erickson JD, Berry RJ, Sambell C, Johansen H, et al. Improvement in stroke mortality in
Canada and the United States, 1990 to 2002. Circulation. 2006;113:13351343.
Yetley EA and Johnson CL. Folate and vitamin B-12 biomarkers in NHANES: history of their measurement and
use. Am J Clin Nutr. 2011;94:322S331S.
1. Water-Soluble Vitamins
71
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
1. Water-Soluble Vitamins
73
Highlights
Serum vitamin C concentrations in the U.S. population showed the following demographic
patterns and characteristics:
The highest concentrations were generally found in the youngest age group and higher
concentrations were found in females compared to males.
The likelihood of being vitamin C deficient or having low serum vitamin C
concentrations varied by demographic subgroup.
Serum vitamin C concentrations less than 11.4 mol/L may indicate vitamin C deficiency.
Compared to non-Hispanic whites, Mexican Americans and non-Hispanic blacks had a lower
risk of deficiency; compared to females, males had a higher risk of deficiency (Figure H.1.e). A
number of important variables that impact vitamin C status are not addressed in this analysis,
including smoking, overweight/obesity, socioeconomic status, and supplement use (Schleicher
2009). Considering that manifest vitamin C deficiency is rare in the United States (Olmedo
2006), persons categorized as vitamin C deficient may more likely experience latent scurvy, which
is characterized by fatigue, irritability, vague, dull aching pains and weight loss (Prinzo 1999).
Serum vitamin C concentrations between 11.423 mol/L are considered low. The prevalence
of deficient (< 11.4 mol/L) and of low (11.423 mol/L) serum vitamin C concentrations was
significantly lower in children than in persons 20 years and older (Figure H.1.f ).
14
10
b
12
4
2
0
Mexican
American
NonHispanic
black
NonHispanic
white
Race/ethnicity
Male
Female
8
6
*
4
2
0
Gender
74
10
b
Prevalence (%)
Prevalence (%)
6-11
60
60
Age in years
< 11.4 mol/L
11.423 mol/L
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Detailed Observations
The selected observations mentioned below are derived from the tables and figures presented next.
Statements about categorical differences between demographic groups noted below are based on
non-overlapping confidence limits from univariate analysis without adjusting for demographic
variables (e.g., age, sex, race/ethnicity) or other blood concentration determinants (e.g., dietary
intake, supplement usage, smoking, BMI). A multivariate analysis may alter the size and statistical
significance of these categorical differences. Furthermore, additional significant differences of
smaller magnitude may be present despite their lack of mention here (e.g., if confidence limits
slightly overlap or if differences are not statistically significant before covariate adjustment has
occurred). For a selection of citations of descriptive NHANES papers related to these biochemical
indicators of diet and nutrition, see Appendix G.
1. Water-Soluble Vitamins
75
76
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
55.2
54.3
56.5
52.4
59.7
75.1
58.0
51.0
51.6
63.0
56.1
(52.7 57.7)
(52.7 56.0)
(54.6 58.4)
(50.9 54.0)
(57.9 61.4)
(73.0 77.2)
(55.9 60.2)
(48.8 53.2)
(49.7 53.4)
(61.5 64.6)
(54.6 57.6)
9.49
7.38
5.75
5.80
7.06
21.3
10.2
6.01
4.92
6.91
6.12
(7.64 12.1)
(5.75 9.18)
(5.05 6.36)
(4.89 6.48)
(5.74 8.15)
(16.1 24.2)
(7.68 11.9)
(4.60 7.31)
(4.06 5.69)
(5.53 7.90)
(5.47 6.91)
15.1
11.9
8.56
8.38
11.2
29.0
15.2
9.00
7.41
10.7
9.61
(11.6 18.7)
(10.0 14.0)
(7.26 9.92)
(7.09 9.70)
(9.61 12.9)
(25.0 33.7)
(11.9 17.0)
(7.48 10.3)
(5.91 8.77)
(8.16 13.6)
(8.17 10.9)
55.1
54.0
56.9
52.6
59.6
74.5
58.6
51.4
52.4
62.5
56.3
(52.8 57.7)
(52.2 55.9)
(54.9 58.7)
(51.2 54.0)
(58.1 61.2)
(72.6 76.5)
(55.9 60.7)
(49.2 53.9)
(50.6 53.9)
(61.1 63.9)
(54.9 57.6)
93.7
95.2
105
98.9
106
123
98.9
92.9
97.2
117
103
(90.7 96.0)
(92.7 97.5)
(103 108)
(96.4 102)
(103 111)
(115 131)
(94.5 103)
(89.4 96.9)
(94.3 101)
(112 121)
(101 105)
101
104
120
110
121
138
109
102
111
131
116
(97.6 107)
(101 110)
(115 125)
(107 115)
(117 128)
(128 153)
(105 115)
(98.0 107)
(105 117)
(127 142)
(113 120)
3,628
3,784
6,089
7,155
7,424
1,703
3,984
3,233
2,635
3,024
14,579
Arithmetic mean and selected percentiles of serum concentrations (in mol/L) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Arithmetic mean
Sample
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
80
20
40
60
Females
Males
Serum vitamin C
(mol/L)
100
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
80
60
40
20
0
Serum vitamin C
(mol/L)
100
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
80
20
40
60
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum vitamin C
(mol/L)
100
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
1. Water-Soluble Vitamins
77
56.1
75.1
58.0
51.0
51.6
63.0
(54.6 57.6)
(73.0 77.2)
(55.9 60.2)
(48.8 53.2)
(49.7 53.4)
(61.5 64.6)
9.61
29.0
15.2
9.00
7.41
10.7
(8.17 10.9)
(25.0 33.7)
(11.9 17.0)
(7.48 10.3)
(5.91 8.77)
(8.16 13.6)
56.3
74.5
58.6
51.4
52.4
62.5
(54.9 57.6)
(72.6 76.5)
(55.9 60.7)
(49.2 53.9)
(50.6 53.9)
(61.1 63.9)
103
123
98.9
92.9
97.2
117
(101 105)
(115 131)
(94.5 103)
(89.4 96.9)
(94.3 101)
(112 121)
14,579
1,703
3,984
3,233
2,635
3,024
52.4
76.3
55.8
47.9
46.7
57.2
(50.9 54.0)
(73.1 79.5)
(53.6 58.1)
(45.3 50.4)
(44.5 48.9)
(54.9 59.4)
8.38
30.4
14.7
8.58
6.38
7.92
(7.09 9.70)
(21.7 37.7)
(11.2 16.5)
(6.68 9.87)
(4.89 7.94)
(6.72 10.1)
52.6
76.2
56.0
48.4
48.2
57.2
(51.2 54.0)
(72.5 78.7)
(53.4 58.5)
(45.2 50.8)
(46.1 50.2)
(54.7 59.4)
98.9
123
94.0
87.5
88.4
110
(96.4 102)
(113 138)
(91.2 100)
(82.8 95.4)
(84.8 96.3)
(105 118)
7,155
837
2,022
1,463
1,305
1,528
59.7
73.8
60.4
54.1
56.2
67.8
(57.9 61.4)
(71.1 76.6)
(57.8 62.9)
(51.5 56.7)
(53.7 58.7)
(65.9 69.7)
11.2
28.5
15.7
9.90
9.34
14.3
(9.61 12.9)
(20.3 35.9)
(11.0 18.8)
(7.73 11.5)
(6.29 12.0)
(10.9 16.4)
59.6
72.4
61.4
55.3
56.4
67.0
(58.1 61.2)
(69.2 75.9)
(58.6 63.9)
(51.9 58.6)
(53.6 58.2)
(65.1 69.0)
106
123
102
96.1
103
121
(103 111)
(115 131)
(98.2 110)
(91.9 101)
(97.4 110)
(116 129)
7,424
866
1,962
1,770
1,330
1,496
Males
Females
Arithmetic mean
5th
95th
55.2
73.4
58.5
52.2
49.5
51.8
(52.7 57.7)
(69.4 77.4)
(56.4 60.5)
(49.4 54.9)
(46.9 52.1)
(47.8 55.8)
15.1
28.3
20.3
15.9
9.55
9.48
(11.6 18.7)
(20.7 37.8)
(14.9 23.9)
(12.2 20.6)
(7.54 14.0)
(2.78 14.5)
55.1
74.2
59.0
52.4
51.0
50.5
(52.8 57.7)
(71.7 76.4)
(57.4 60.7)
(49.9 54.5)
(47.5 54.7)
(46.0 55.9)
93.7
113
92.7
85.7
83.6
93.6
(90.7 96.0)
(107 130)
(90.6 95.2)
(80.9 90.6)
(80.0 85.2)
(88.9 103)
3,628
563
1,266
782
470
547
52.7
73.4
56.7
49.6
46.2
44.8
(50.0 55.5)
(69.0 77.8)
(54.3 59.1)
(46.2 53.1)
(42.8 49.7)
(41.6 47.9)
13.6
28.2
18.9
14.2
8.27
7.27
(8.67 17.5)
(20.8 37.5)
(10.6 23.3)
(7.50 22.1)
(4.43 13.6)
(1.70 10.0)
53.3
74.6
57.4
50.8
46.3
44.0
(50.4 55.7)
(71.4 77.2)
(55.2 59.5)
(47.7 54.4)
(43.5 53.5)
(38.1 48.9)
90.8
113
90.1
79.5
76.5
86.3
(87.6 94.5)
(108 134)
(86.9 93.0)
(73.6 86.6)
(73.9 87.2)
(78.5 94.2)
1,762
275
628
351
239
269
58.0
73.4
60.3
55.1
53.1
57.7
(55.4 60.6)
(69.1 77.7)
(57.8 62.8)
(51.7 58.6)
(49.9 56.3)
(51.6 63.8)
18.6
26.5
22.4
18.5
10.6
14.3
(14.1 21.5)
(18.0 41.2)
(18.8 24.7)
(12.8 22.6)
(7.49 18.2)
(1.10 23.2)
58.1
73.3
60.7
54.0
54.5
58.7
(54.8 60.8)
(70.7 76.2)
(58.4 62.7)
(50.6 58.0)
(50.0 58.9)
(48.3 64.2)
95.1
113
95.1
90.0
85.2
97.9
(92.4 99.2)
(103 129)
(90.9 104)
(84.3 102)
(83.9 92.9)
(93.4 116)
1,866
288
638
431
231
278
Males
Females
78
50th
Sample
size
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
54.3
73.4
61.5
51.5
49.2
49.8
(52.7 56.0)
(70.8 75.9)
(59.7 63.2)
(49.4 53.5)
(46.3 52.1)
(46.8 52.8)
11.9
39.7
28.1
14.7
8.58
6.69
(10.0 14.0)
(34.0 43.0)
(25.9 30.3)
(11.2 16.9)
(4.80 11.2)
(4.99 8.42)
54.0
72.8
61.3
50.4
48.9
50.8
(52.2 55.9)
(69.0 75.9)
(59.1 63.2)
(48.1 53.2)
(45.3 52.7)
(47.0 54.1)
95.2
107
95.0
87.3
93.1
95.9
(92.7 97.5)
(103 118)
(91.7 98.3)
(83.4 91.3)
(83.9 101)
(90.8 101)
3,784
544
1,400
711
619
510
52.6
75.3
59.6
48.7
46.7
45.6
(51.0 54.1)
(71.0 79.6)
(58.0 61.2)
(46.3 51.2)
(43.3 50.1)
(41.0 50.3)
10.2
42.4
28.6
12.4
7.24
5.02
(7.77 12.6)
(34.1 44.3)
(24.2 30.2)
(6.93 16.2)
(4.00 10.4)
(2.96 6.19)
52.1
75.8
58.8
48.0
46.6
45.6
(50.4 54.2)
(69.8 79.9)
(56.4 61.0)
(44.0 50.9)
(42.2 51.3)
(38.6 50.9)
92.8
108
91.6
81.5
82.8
93.0
(90.2 97.3)
(104 118)
(89.5 96.1)
(76.6 91.0)
(77.1 97.4)
(89.0 106)
1,895
272
735
337
291
260
55.8
71.3
63.4
53.7
51.3
52.7
(53.7 58.0)
(68.9 73.7)
(60.7 66.1)
(50.9 56.6)
(47.8 54.8)
(48.8 56.7)
13.5
36.8
27.6
15.7
9.84
9.64
(11.3 15.8)
(30.8 41.4)
(25.9 30.8)
(11.5 21.5)
(4.02 14.5)
(4.66 11.2)
55.8
68.8
63.8
52.7
50.4
54.0
(53.5 58.1)
(67.0 73.1)
(60.6 67.0)
(49.4 56.3)
(47.2 55.2)
(50.1 58.2)
95.9
106
96.0
90.5
95.9
96.5
(94.1 99.8)
(102 114)
(92.8 102)
(86.6 95.8)
(86.6 106)
(90.0 108)
1,889
272
665
374
328
250
Males
Females
Arithmetic mean
5th
50th
95th
Sample
size
56.5
75.6
57.2
50.6
52.0
64.8
(54.6 58.4)
(72.5 78.8)
(54.0 60.4)
(47.8 53.3)
(49.7 54.3)
(63.0 66.7)
8.56
25.7
12.3
7.99
6.80
11.7
(7.26 9.92)
(18.7 31.8)
(9.88 15.7)
(6.39 8.99)
(5.56 8.33)
(8.22 14.7)
56.9
74.8
58.0
51.2
52.8
63.9
(54.9 58.7)
(70.9 77.7)
(53.2 61.5)
(47.7 55.1)
(51.2 55.2)
(62.4 65.3)
105
128
101
96.2
99.8
118
(103 108)
(118 144)
(95.4 107)
(91.2 102)
(96.0 103)
(114 123)
6,089
436
1,037
1,442
1,346
1,828
52.3
76.5
54.9
47.2
47.0
58.5
(50.4 54.1)
(71.7 81.4)
(51.7 58.1)
(44.2 50.3)
(44.3 49.8)
(56.0 61.1)
7.71
25.4
12.6
7.92
6.19
8.15
(6.50 8.82)
(14.0 34.1)
(9.73 16.2)
(6.52 8.79)
(4.90 7.44)
(6.84 11.5)
52.4
75.8
54.8
47.5
48.5
58.4
(50.5 54.5)
(69.2 80.6)
(51.4 59.1)
(44.1 50.7)
(46.4 51.0)
(55.6 60.7)
101
127
94.4
93.8
90.2
112
(98.2 104)
(117 155)
(91.6 104)
(85.8 98.7)
(86.4 101)
(106 119)
2,990
210
524
636
687
933
60.5
74.7
59.6
53.9
57.0
70.0
(58.2 62.8)
(70.3 79.0)
(55.8 63.5)
(50.4 57.4)
(53.9 60.0)
(67.7 72.3)
9.92
25.2
12.0
8.06
8.63
15.0
(8.18 11.7)
(9.65 36.1)
(8.98 15.7)
(5.40 9.86)
(5.81 11.1)
(10.9 17.9)
60.7
72.8
61.1
56.0
57.4
69.1
(58.5 62.8)
(68.7 78.2)
(56.9 64.7)
(50.2 60.7)
(53.5 59.8)
(66.5 72.6)
110
129
104
99.0
105
123
(106 114)
(115 145)
(98.6 120)
(93.1 106)
(98.0 113)
(117 131)
3,099
226
513
806
659
895
Males
Females
1. Water-Soluble Vitamins
79
55.8
56.4
(53.1 58.5)
(54.8 58.0)
8.55
11.1
(6.57 10.2)
(9.22 12.4)
56.3
56.3
(53.4 58.8)
(55.0 57.6)
103
102
(101 108)
(99.2 105)
7,277
7,302
20032004
20052006
74.3
75.9
(70.9 77.8)
(73.1 78.7)
27.8
32.0
(16.6 35.5)
(26.2 36.6)
73.7
75.0
(70.8 76.8)
(72.4 78.1)
126
121
(112 139)
(114 130)
823
880
20032004
20052006
56.3
59.7
(52.9 59.8)
(57.0 62.4)
13.6
17.0
(10.2 16.2)
(13.4 20.8)
56.2
60.3
(52.1 60.0)
(57.3 63.5)
98.4
99.3
(93.6 106)
(93.0 107)
2,016
1,968
20032004
20052006
49.7
52.2
(46.0 53.5)
(49.7 54.8)
7.34
11.3
(5.42 9.22)
(9.71 12.5)
50.0
52.8
(45.7 54.1)
(49.7 55.7)
95.0
91.9
(87.9 102)
(87.8 97.1)
1,540
1,693
20032004
20052006
52.6
50.6
(49.4 55.8)
(48.3 52.9)
6.71
7.92
(5.02 8.71)
(5.51 10.9)
53.5
51.3
(51.2 56.6)
(48.9 53.4)
100
94.4
(95.5 105)
(90.1 100)
1,266
1,369
20032004
20052006
63.2
62.9
(60.8 65.6)
(60.7 65.1)
10.3
11.8
(7.88 13.3)
(6.99 15.1)
62.5
62.6
(60.2 64.7)
(60.7 64.5)
119
113
(114 124)
(108 119)
1,632
1,392
20032004
20052006
52.2
52.7
(49.4 54.9)
(51.0 54.3)
7.32
9.74
(5.74 9.08)
(7.88 11.0)
52.7
52.4
(50.1 55.2)
(50.9 53.9)
100
97.3
(97.7 103)
(93.7 102)
3,590
3,565
20032004
20052006
59.3
60.0
(56.4 62.3)
(57.9 62.1)
9.76
13.1
(7.89 11.4)
(11.1 15.6)
59.8
59.4
(56.7 62.5)
(57.7 61.4)
108
105
(102 115)
(101 111)
3,687
3,737
20032004
20052006
55.4
55.1
(50.6 60.2)
(52.8 57.5)
14.0
17.1
(7.30 20.1)
(10.8 20.6)
55.6
54.6
(51.7 60.0)
(51.7 57.5)
93.1
94.2
(89.3 97.1)
(90.8 97.3)
1,766
1,862
20032004
20052006
52.9
55.7
(50.3 55.4)
(53.6 57.9)
11.1
13.0
(7.65 13.5)
(9.49 16.8)
52.0
55.4
(49.7 55.5)
(53.5 57.6)
93.7
95.6
(90.5 99.1)
(94.0 99.2)
1,880
1,904
20032004
20052006
56.7
56.3
(53.1 60.3)
(54.5 58.0)
7.82
10.0
(6.24 9.09)
(7.77 11.7)
57.4
56.4
(53.1 60.6)
(54.7 58.0)
108
103
(103 115)
(100 106)
3,103
2,986
Age group
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
80
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
140
120
100
80
80
50th Percentile
70
60
50
40
40
20
10
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
1. Water-Soluble Vitamins
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0
0304
0506
5th Percentile
30
NHW
81
14,579
6.0
(4.9 7.3)
611 years
1219 years
2039 years
4059 years
60 years and older
1,703
3,984
3,233
2,635
3,024
0.8
2.8
6.9
8.1
5.1
(0.4 1.7)
(1.9 4.2)
(5.4 8.9)
(6.3 10.5)
(3.8 6.8)
191,000
931,000
5,533,000
6,435,000
2,362,000
Males
Females
7,155
7,424
7.3
4.8
(5.9 9.0)
(3.8 6.0)
9,258,000
6,476,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
3,628
3,784
6,089
3.1
4.3
7.1
(2.1 4.6)
(3.2 5.7)
(5.8 8.7)
715,000
1,341,000
12,807,000
Gender
Race/ethnicity
15,757,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
82
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,277
7,302
7.3
4.8
(5.5 9.6)
(3.7 6.1)
20032004
20052006
823
880
1.5
(0.7 3.6)
372,000
20032004
20052006
2,016
1,968
3.3
2.3
(1.9 5.7)
(1.2 4.5)
1,090,000
783,000
20032004
20052006
1,540
1,693
9.3
4.5
(6.7 12.8)
(3.2 6.4)
7,437,000
3,618,000
20032004
20052006
1,266
1,369
9.2
7.1
(6.5 13.0)
(4.7 10.5)
7,294,000
5,815,000
20032004
20052006
1,632
1,392
5.5
4.7
(3.9 7.5)
(2.8 7.8)
2,543,000
2,272,000
20032004
20052006
3,590
3,565
8.4
6.1
(6.0 11.8)
(4.8 7.7)
10,772,000
7,914,000
20032004
20052006
3,687
3,737
6.1
3.5
(4.6 8.0)
(2.4 5.1)
8,247,000
4,827,000
20032004
20052006
1,766
1,862
3.7
2.6
(2.0 6.7)
(1.6 4.2)
840,000
627,000
20032004
20052006
1,880
1,904
4.8
3.8
(3.4 6.8)
(2.3 6.2)
1,510,000
1,199,000
20032004
20052006
3,103
2,986
8.6
5.6
(6.4 11.5)
(4.2 7.4)
15,534,000
10,186,000
Age group
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
19,054,000
12,746,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
1. Water-Soluble Vitamins
83
References
Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose
supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report
no. 9. Arch Ophthalmol. 2001;119:14391452.
Gibson RS. Principles of nutritional assessment (2nd edn.). New York: Oxford University Press; 2005.
Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for vitamin C, vitamin E, selenium,
and carotenoids. Washington, D.C.: National Academy Press; 2000.
Jacob RA. Assessment of human vitamin C status. J Nutr. 1990;120 Suppl 11:14801485.
McCoy LF, Bowen MB, Xu M, Chen H, Schleicher RL. Improved HPLC assay for measuring serum vitamin C
with 1-methyluric acid used as an electrochemically active internal standard. Clin Chem. 2005;51:10621064.
Olmedo JM, Yiannias JA, Windgassen EB, Gornet MK. Scurvy: a disease almost forgotten. Int J Dermatol.
2006;45:909913.
Prinzo ZW. Scurvy and its prevention and control in major emergencies. Geneva, Switzerland: World Health
Organization, 1999. (WHO publication WHO/NHD/99.11.)
Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in
the United States: 20032004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr.
2009;90:12521263.
Shekelle P, Morton S, Hardy M. Effect of Supplemental Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10
for the Prevention and Treatment of Cardiovascular Disease. Evid Report Tech Asses No. 83. AHRQ Publication
No. 03-E043. Rockville, MD: Agency for Healthcare Research and Quality. July 2003.
84
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Polyunsaturated
Linoleic acid (18:2n-6)
alpha-Linolenic acid (18:3n-3)
gamma-Linolenic acid (18:3n-6)
Eicosadienoic acid (20:2n-6)
homo-gamma-Linolenic acid
(20:3n-6)
Arachidonic acid (20:4n-6)
Eicosapentaenoic acid (20:5n-3)
Docosatetraenoic acid (22:4n-6)
Docosapentaenoic acid (22:5n-3)
Docosapentaenoic acid (22:5n-6)
Docosahexaenoic acid (22:6n-3)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
8787
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
tomatoes, eggs, nuts and seeds, and snack foods. Plasma concentrations of tocopherols vary widely
among healthy individuals and are highly correlated with plasma lipid concentrations (Ford 1999;
Ford 2006).
Health Effects. Inadequate or excessive intake of vitamins A or E can lead to various disorders.
For example, vitamin A deficiency, considered to be the main cause of childhood blindness in
low-income countries (Roodhooft 2002), is a rare condition in the United States. Prominent signs
of vitamin A deficiency include night blindness, corneal thinning, and conjunctival metaplasia.
Vitamin A is also essential for proper immune function, epithelial growth and repair, bone
growth, reproduction, and normal embryonic and fetal development (West 2006). Acute toxicity
resulting from single or short-term large doses of preformed vitamin A is characterized by nausea,
vomiting, headache, vertigo, blurred vision, increased cerebrospinal fluid pressure, and lack of
muscular coordination. Central nervous system effects, liver abnormalities, bone and skin changes,
and other nonspecific adverse effects can be indicative of chronic hypervitaminosis A. Consuming
excess amounts of vitamin A during early pregnancy may lead to serious birth defects (Institute of
Medicine 2001).
Serum or plasma concentrations of carotenoids are considered among the best biological markers
for fruit and vegetable intake. The strongest dietary predictors of serum carotenoid concentrations
are fruits (for sources of beta-cryptoxanthin), carrots and root vegetables (for sources of carotenes),
and tomato products (for sources of trans-lycopene) (Al-Delaimy 2005). Research studies have
shown inconsistencies in the relation between carotenoid intake and protection from cancer.
Carotenoids in foods, even when consumed over long periods and in large amounts are not
known to produce adverse health effects. However, results of intervention studies of smokers
who used 2030 milligrams (mg) of beta-carotene per day showed that this group had more lung
cancers than placebo-treated groups (Albanes 1996; Redlich 1998).
Vitamin E deficiency occurs only rarely in people, and overt deficiency symptoms in people
consuming low-vitamin E diets have never been described (Institute of Medicine 2000). The
main manifestation of vitamin E deficiency is peripheral neuropathy characterized by the
degeneration of the large-caliber axons of sensory neurons (Institute of Medicine 2000). The
upper limit (UL) for vitamin E intake (1000 mg/day) is based on hemorrhagic effects; however,
a causal association between excess alpha-tocopherol intake in apparently healthy individuals and
adverse health outcomes has not consistently been shown (Institute of Medicine 2000). Studies
evaluating tocopherols to reduce the risk for cardiovascular disease demonstrated inconsistent
findings (Agency for Healthcare Research and Quality 2003). The American Heart Association
currently advises that antioxidant supplements (such as vitamins E and C and beta-carotene)
should not be used for primary or secondary prevention of cardiovascular disease (Lichtenstein
2006). Nevertheless, the American Heart Association recommends consuming food sources of
antioxidant nutrients, principally from a variety of plant-derived foods such as fruits, vegetables,
whole grains, and vegetable oils.
Intake Recommendations. The National Academy of Sciences has established dietary-requirement
intake values for vitamins A and E by determining the Adequate Intake (AI) for infants and the
recommended dietary allowance (RDA) for older age groups (Institute of Medicine 2000 and 2001).
The RDA for vitamin A in retinol equivalents is 900 g/day for men and 700 g/day for women;
for children and adolescents (118 years), the RDA ranges from 300900 g/day. For infants (012
months), the AI is set at 400500 g/day of retinol equivalents. The Tolerable Upper Intake Level
(UL) for adults is set at 3,000 g/day of preformed vitamin A, whereas the UL for infants (600 g/
day), younger children 18 years (600-900 g/day), older children 913 years (1700 g/day), and
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
8989
adolescents 1418 years (2800 g/day) are age-dependent. For adults, the RDA for vitamin E is 15
mg/day of alpha-tocopherol; for children and adolescents (118 years), the RDA ranges from 615
mg/day. There is no RDA for other forms of vitamin E, such as gamma-tocopherol. The UL for
vitamin E which applies to all eight stereoisomers of alpha-tocopherol is 1000 mg/day for adults;
a UL for infants could not be established and thus only food and formula sources of dietary intake
are recommended. The UL for children and adolescents ranges from 200-800 mg/day of vitamin
E. Although no quantitative recommendations are available for the intake of carotenoids, existing
recommendations support increased consumption of carotenoid-rich fruits and vegetables. Current
public health guidelines advise that people consume at least 2.5 cups of fruits and vegetables a day,
depending on caloric need, to ensure adequate nutrient intake (U.S. Department of Agriculture and
U.S. Department of Health and Human Services 2010).
Biochemical Indicators and Methods. The best way to determine inadequate vitamin A status
is through hepatic biopsy, but this invasive procedure is unsuitable for population studies. Serum
or plasma retinol is measured by use of high performance liquid chromatography (HPLC) with
ultraviolet (UV) detection after separation from its carrier retinol binding protein (RBP). Because
retinol is closely correlated with RBP, the measurement of this transport protein through enzymelinked immunosorbent assay (ELISA) has also been used to assess vitamin A status. In most
populations, serum RBP has been shown to be a suitable surrogate for retinol. Serum or plasma
concentrations of carotenoids are measured by use of HPLC and visible light (450 nm) absorbance.
Clinical laboratories typically use conventional units for serum concentrations of these fat-soluble
micronutrients (g per deciliter [dL]). Conversion factors to international system (SI) units are 1
g/dL = 0.0349 micromole per liter (mmol/L) for vitamin A and 1 g/dL = 0.02322 mmol/L for
vitamin E. Depending on its molecular weight, each carotenoid has a specific conversion factor.
International reference materials for vitamins A and E and carotenoids are available from the U.S.
National Institutes of Standards and Technology (https://www-s.nist.gov/srmors/view_detail.
cfm?srm=968e). Among most laboratories participating in an external quality assurance program,
standardized HPLC methods for measuring fat-soluble micronutrients show consistent agreement
of values (Duewer 2000).
The diagnosis of vitamin A or E deficiency is supported by measuring these concentrations in the
body. People with serum retinol concentrations of less than 20 g/dL are considered vitamin A
deficient, and those with serum concentrations of less than 10 g/dL are considered severely deficient
(West 2006). Serum retinol values do not always reflect total body status because of homeostatic
control and therefore are often not useful for assessing
the vitamin A status of individuals. Additional tests
may be required to confirm vitamin A deficiency
when 20 g/dL is used as a cutoff (Gibson 2005). The
distribution of serum retinol values in a population
together with the prevalence of individuals with serum
retinol values below a given cutoff point provide
important information about the vitamin A status of
a population. WHO (2011) recommends using the
prevalence of serum retinol concentrations of less than
or equal to 20 g/dL to define public health problems
involving vitamin A deficiency as mild (29%),
moderate (1019%) or severe (20%). In chronic
hypervitaminosis A, serum concentrations are generally
greater than 100 g/dL (Bendich 1989). Carotenoid
90
90
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
deficiency has no defined serum concentrations. The laboratory diagnosis of vitamin E deficiency is
based on serum concentrations of alpha-tocopherol (less than 500 g/dL or less than 0.8 mg of alphatocopherol per gram of total lipids) (Beers 2006). Such concentrations are associated with in vitro
hydrogen peroxide-induced red blood cell lysis, not with clinical deficiency symptoms (Institute of
Medicine 2000).
Data in NHANES. The fat-soluble micronutrients vitamin A, E, and carotenoids presented in
this report were measured by a single assay panel employing HPLC separation and detection by
use of UV or visible light (HPLC-UV/vis). This is the same method used during the first four
years of the continuous NHANES survey (1999-2002).
Since 1971, various fat-soluble micronutrients have been measured in the serum of NHANES
participants. In NHANES III (19881994), clinically low concentrations of serum retinol were
uncommon in U.S. residents aged 4 years and older, although racial/ethnic and socioeconomic
differences existed (Ballew 2001). Variations in serum carotenoid concentrations by ethnicity
and sex were found for adults, children, and adolescents (Ford 2000; Ford 2002). Ford et al. also
found sociodemographic variations in serum concentrations of alpha-tocopherol among U.S.
adults in NHANES III (1999) and alpha- and gamma-tocopherol in NHANES 19992000
(2006). Application of the most common cut-off value for serum alpha-tocopherol concentrations
in NHANES 19992000 (500 g/dL), demonstrated a low prevalence of vitamin E deficiency,
despite the fact that the U.S. Department of Agriculture-estimated dietary intakes of vitamin E
were low and that most of the U.S. population did not meet dietary intake recommendations.
For more information on these fat-soluble micronutrients, see the Institute of Medicines
Dietary Reference Intake reports (Institute of Medicine 2000 and 2001) and the vitamin fact
sheets from the National Institutes of Health, Office of Dietary Supplements (http://ods.od.nih.
gov/Health_Information/Vitamin_and_Mineral_Supplement_Fact_Sheets.aspx).
Highlights
Serum concentrations of fat-soluble micronutrients (vitamin A, E, and carotenoids) in the U.S.
population showed the following demographic patterns and characteristics:
With few exceptions, the highest concentrations of fat-soluble micronutrients were
found in persons 60 years and older.
No consistent pattern was observed with regard to gender or race/ethnicity.
The likelihood of being vitamin A or E deficient was very low throughout the
population.
The likelihood of vitamin A excess was also very low, but it increased with increasing age.
For more than 20 years, the majority of the U.S. population (greater than 95%) has had adequate
serum concentrations of vitamin A (> 20 g/dL) and vitamin E (> 500 g/dL).
Despite NHANES 20012002 dietary intake data demonstrating that 93% of the U.S.
population consumed less than the Estimated Average Requirement (EAR) for vitamin E
(Moshfegh 2005), for decades mean serum vitamin E concentrations have remained consistently
adequate (Figure H.2.a), with less than 1% of the population vitamin E deficient. Analyses of
NHANES data showed that in 19992000, 52% of adults (Rock 2007) and in 20032006,
49% of the total U.S. population (Bailey 2011) used dietary supplements; thus, the intake data
(food and supplements) for vitamin E seem to be inconsistent with the biomarker data. Several
explanatory possibilities have been raised, including a suggestion that the intake of fats (and
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
9191
fat-soluble nutrients) is under-reported in overweight and obese subjects, the database of food
values is not accurate, and/or that the EAR for vitamin E needs adjustment. Low intake without
widespread manifestation of deficiency suggests the need for further evaluations to determine
whether improved estimates are necessary, either in the nutrient tables or in dietary intake.
1988-1994
1200
b
a
c
a
1999-2002
b
a
2005-2006
b
a
a
a
1000
Serum vitamin E (g/dL)
b
b
800
600
400
200
0
Total
population
Males
Females
Mexican
American
NonHispanic
NonHispanic
black
white
Figure H.2.a. Age-adjusted geometric mean concentrations of serum vitamin E (alpha-tocopherol) in the U.S. population aged 6 years
and older by gender or race/ethnicity, National Health and Nutrition Examination Survey, 19882006.
Error bars represent 95% confidence intervals. Within a demographic group, bars not sharing a common letter differ (p < 0.05). Age adjustment was
done using direct standardization.
Detailed Observations
The selected observations mentioned below are derived from the tables and figures presented next.
Statements about categorical differences between demographic groups noted below are based on
non-overlapping confidence limits from univariate analysis without adjusting for demographic
variables (e.g., age, gender, race/ethnicity) or other blood concentration determinants (e.g., dietary
intake, supplement usage, smoking, BMI). A multivariate analysis may alter the size and statistical
significance of these categorical differences. Furthermore, additional significant differences of
smaller magnitude may be present despite their lack of mention here (e.g., if confidence limits
slightly overlap or if differences are not statistically significant before covariate adjustment has
occurred). For a selection of citations of descriptive NHANES papers related to these biochemical
indicators of diet and nutrition, see Appendix G.
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
9393
94
94
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
48.4
48.3
57.4
57.2
52.4
36.4
46.5
54.3
58.7
64.4
54.7
(47.3 49.5)
(47.3 49.3)
(56.4 58.4)
(56.3 58.2)
(51.3 53.5)
(35.6 37.2)
(45.4 47.7)
(53.3 55.3)
(57.7 59.7)
(62.8 66.1)
(53.8 55.6)
27.8
25.7
31.5
30.3
28.9
22.8
28.9
31.2
33.1
36.4
29.6
(26.2 28.6)
(23.8 27.5)
(30.6 32.4)
(29.2 31.2)
(27.7 30.1)
(19.9 24.8)
(28.6 29.6)
(29.2 32.1)
(31.4 34.2)
(31.6 38.8)
(28.7 30.5)
30.3
28.8
34.8
33.6
31.9
25.6
32.0
33.9
36.8
40.2
32.5
(29.3 31.2)
(27.6 29.8)
(33.0 36.2)
(32.7 34.8)
(31.2 32.6)
(24.3 26.9)
(30.6 33.0)
(32.2 35.1)
(36.0 38.0)
(38.2 43.0)
(31.8 33.2)
48.8
48.1
57.9
58.0
52.4
36.6
46.0
54.7
59.5
64.9
55.2
(46.8 50.2)
(47.0 49.5)
(56.8 59.0)
(57.1 59.0)
(50.8 53.8)
(35.9 37.3)
(44.6 47.5)
(53.5 55.6)
(58.1 60.4)
(63.1 67.0)
(54.2 56.1)
73.7
82.0
89.8
89.0
85.9
52.4
69.6
84.4
90.3
99.8
87.8
(71.9 77.0)
(78.4 85.5)
(87.6 93.3)
(86.5 93.0)
(83.3 88.7)
(49.1 54.3)
(66.9 73.1)
(81.9 87.9)
(87.2 94.3)
(96.2 102)
(85.6 90.5)
82.1
89.7
100
100
94.8
54.4
75.7
89.1
100
108
96.7
(76.2 88.4)
(86.1 93.6)
(95.6 104)
(93.3 104)
(89.8 103)
(53.3 57.3)
(71.4 82.9)
(87.2 93.3)
(94.7 107)
(105 115)
(93.1 101)
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older,
National Health and Nutrition Examination Survey, 20052006.
Selected percentiles (95% conf. interval)
Geometric mean
(95% conf. interval)
2.5th
5th
50th
95th
97.5th
1,844
1,891
2,973
3,547
3,707
860
1,954
1,688
1,365
1,387
7,254
Sample
size
20
40
60
Females
Males
Serum vitamin A
(g/dL)
80
Overall
611
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
20
40
60
80
NonHispanic Blacks
1219
Serum vitamin A
(g/dL)
1219
611
1219
4059
60+
611
1219
80
Females
2039
4059
60+
Males
20
40
60
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum vitamin A
(g/dL)
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
9595
Geometric mean
10th
50th
90th
Sample
size
54.7
36.4
46.5
54.3
58.7
64.4
(53.8 55.6)
(35.6 37.2)
(45.4 47.7)
(53.3 55.3)
(57.7 59.7)
(62.8 66.1)
36.6
28.0
35.2
38.1
41.2
46.4
(35.8 37.4)
(27.5 29.1)
(33.9 35.9)
(36.5 39.2)
(39.5 43.0)
(44.7 47.9)
55.2
36.6
46.0
54.7
59.5
64.9
(54.2 56.1)
(35.9 37.3)
(44.6 47.5)
(53.5 55.6)
(58.1 60.4)
(63.1 67.0)
80.0
47.5
63.2
77.7
81.0
88.4
(78.1 82.2)
(45.7 50.1)
(60.7 66.9)
(74.1 81.6)
(79.0 85.2)
(86.0 91.7)
7,254
860
1,954
1,688
1,365
1,387
57.2
36.4
48.2
59.1
61.8
66.0
(56.3 58.2)
(35.4 37.3)
(46.9 49.6)
(57.7 60.5)
(60.7 63.0)
(63.9 68.1)
38.5
28.1
36.4
44.4
44.2
48.4
(37.8 39.2)
(26.4 29.1)
(35.3 37.7)
(42.3 46.0)
(41.6 47.1)
(46.0 50.0)
58.0
36.3
48.1
58.4
63.2
66.4
(57.1 59.0)
(35.0 37.2)
(46.3 49.8)
(56.8 60.2)
(62.4 64.2)
(63.7 68.7)
81.8
47.5
64.5
80.9
84.5
90.4
(79.7 85.0)
(45.7 51.6)
(62.9 67.4)
(76.8 84.5)
(80.1 92.0)
(86.3 97.2)
3,547
427
980
738
673
729
52.4
36.5
44.7
50.0
55.9
63.2
(51.3 53.5)
(35.3 37.8)
(43.5 45.9)
(48.7 51.3)
(54.1 57.7)
(61.3 65.2)
35.6
28.0
33.7
34.5
39.9
45.1
(34.3 36.4)
(27.5 29.4)
(33.3 35.0)
(32.7 36.1)
(36.9 41.2)
(43.0 47.2)
52.4
36.9
43.8
49.3
55.8
63.9
(50.8 53.8)
(35.9 38.0)
(42.7 45.1)
(48.3 50.9)
(53.8 58.5)
(62.5 65.7)
77.5
47.0
60.7
72.6
78.4
87.7
(75.0 79.0)
(45.1 52.3)
(57.0 66.6)
(69.5 75.9)
(74.2 82.8)
(84.0 91.2)
3,707
433
974
950
692
658
Males
Females
Geometric mean
10th
50th
90th
Sample
size
48.4
35.6
44.9
50.1
53.6
55.5
(47.3 49.5)
(34.4 37.0)
(43.3 46.4)
(49.1 51.2)
(52.4 54.8)
(52.8 58.3)
33.4
27.6
34.1
36.0
39.0
40.8
(32.6 34.2)
(24.8 28.9)
(33.4 35.0)
(33.3 37.3)
(36.6 41.0)
(37.3 42.8)
48.8
35.8
44.4
50.3
52.6
57.0
(46.8 50.2)
(33.8 37.6)
(43.2 46.1)
(48.7 53.3)
(50.7 55.6)
(54.7 58.4)
68.6
46.2
58.8
69.1
71.7
78.1
(66.7 70.3)
(45.0 48.2)
(55.6 64.7)
(66.8 72.7)
(67.2 85.3)
(72.9 85.4)
1,844
295
646
449
246
208
51.9
35.6
47.4
54.8
59.1
57.6
(50.0 53.9)
(33.9 37.4)
(45.6 49.3)
(52.4 57.3)
(56.0 62.3)
(53.3 62.3)
36.5
27.2
36.1
41.3
45.8
42.6
(33.7 38.5)
(24.0 28.8)
(33.8 38.0)
(36.6 43.9)
(42.9 47.4)
(19.8 47.4)
53.3
35.4
47.0
56.0
57.9
57.6
(50.2 55.9)
(33.0 38.7)
(45.0 48.6)
(54.0 59.0)
(53.9 63.1)
(55.1 62.0)
70.7
46.8
60.9
70.6
77.7
79.5
(68.8 73.3)
(45.6 49.1)
(58.7 65.7)
(68.0 74.3)
(70.5 110)
(70.6 93.0)
883
145
313
198
122
105
44.7
35.7
42.3
45.0
48.4
53.8
(44.0 45.5)
(34.6 36.8)
(41.0 43.7)
(43.9 46.2)
(47.1 49.7)
(50.9 56.9)
32.1
28.0
33.3
31.9
35.6
39.4
(31.3 32.7)
(24.0 29.4)
(32.2 33.8)
(29.8 33.8)
(32.4 37.4)
(32.9 42.3)
43.7
36.0
41.6
43.2
49.1
53.5
(42.7 45.2)
(34.3 37.6)
(40.2 43.0)
(41.7 46.6)
(46.5 50.2)
(51.4 58.9)
64.2
45.7
55.9
66.6
63.9
75.9
(62.1 67.0)
(42.2 52.7)
(52.3 61.5)
(61.2 69.5)
(57.7 81.3)
(72.9 83.0)
961
150
333
251
124
103
Males
Females
96
96
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
48.3
35.6
41.1
47.3
53.2
59.9
(47.3 49.3)
(34.0 37.3)
(40.0 42.2)
(45.8 48.9)
(51.4 55.0)
(56.3 63.7)
32.0
26.6
30.5
32.3
35.4
40.1
(31.2 32.8)
(24.0 28.5)
(29.4 31.3)
(29.8 35.3)
(33.3 37.2)
(36.2 45.6)
48.1
35.7
40.9
47.9
53.7
60.7
(47.0 49.5)
(34.5 36.8)
(39.7 42.6)
(44.9 50.5)
(50.3 57.2)
(56.6 64.5)
72.1
47.3
54.2
67.7
77.1
85.1
(70.0 75.1)
(44.6 51.8)
(52.8 57.5)
(63.6 71.6)
(72.8 85.7)
(78.8 91.4)
1,891
240
665
368
335
283
51.2
35.4
42.2
53.3
57.3
60.8
(49.9 52.5)
(34.1 36.8)
(40.8 43.7)
(52.1 54.5)
(54.9 59.8)
(57.0 64.9)
34.0
26.2
30.6
38.9
39.0
40.0
(32.9 35.2)
(23.2 28.7)
(28.8 32.0)
(35.7 40.4)
(35.8 42.6)
(33.9 46.7)
51.9
35.3
42.0
54.1
58.4
62.5
(50.2 53.6)
(33.5 36.6)
(39.7 44.7)
(52.3 55.5)
(54.0 62.9)
(59.9 64.7)
74.8
46.2
58.1
71.2
84.8
86.0
(70.9 79.0)
(43.7 51.9)
(55.1 60.7)
(65.9 77.7)
(74.8 92.7)
(78.4 110)
949
128
343
170
156
152
45.9
35.8
39.9
42.7
49.9
59.3
(44.7 47.1)
(33.0 39.0)
(38.7 41.2)
(41.1 44.3)
(46.8 53.3)
(55.4 63.4)
31.1
26.7
30.1
29.2
33.4
39.8
(29.4 32.1)
(19.8 28.8)
(29.4 30.8)
(24.3 32.0)
(31.9 34.3)
(36.7 43.8)
44.9
36.1
40.2
42.4
48.8
60.3
(43.5 46.7)
(33.0 38.8)
(38.7 41.7)
(40.4 44.5)
(45.9 53.5)
(54.6 64.5)
70.1
47.6
51.1
60.4
73.3
84.9
(65.9 74.6)
(44.2 54.2)
(49.9 53.1)
(57.4 63.5)
(68.1 84.7)
(77.9 90.2)
942
112
322
198
179
131
Males
Females
Geometric mean
10th
50th
90th
Sample
size
57.4
36.8
48.5
57.5
60.4
65.4
(56.4 58.4)
(35.5 38.2)
(46.8 50.2)
(55.9 59.1)
(59.2 61.6)
(63.8 67.0)
39.0
28.6
37.0
41.4
43.3
47.1
(37.8 40.0)
(26.6 30.1)
(35.5 38.4)
(39.1 43.0)
(41.2 45.6)
(45.3 48.8)
57.9
37.1
48.3
57.1
60.5
66.0
(56.8 59.0)
(35.4 38.2)
(45.9 50.0)
(56.0 58.6)
(59.3 62.6)
(63.8 67.9)
82.0
47.6
66.2
81.4
81.9
89.5
(79.8 85.3)
(45.3 53.0)
(63.1 69.3)
(77.1 85.6)
(79.2 88.0)
(86.7 92.6)
2,973
231
499
714
683
846
59.7
37.0
50.2
61.8
63.3
66.8
(58.5 60.9)
(35.6 38.6)
(48.3 52.2)
(59.9 63.8)
(61.5 65.2)
(64.6 69.0)
40.9
28.6
38.5
47.1
45.3
49.7
(39.4 41.9)
(25.1 30.3)
(35.2 40.4)
(45.1 48.4)
(40.1 49.9)
(46.1 50.4)
60.4
37.0
49.8
60.8
64.0
67.1
(58.9 62.1)
(35.1 38.4)
(47.5 52.0)
(58.3 63.5)
(62.7 66.1)
(63.8 70.2)
84.1
47.4
66.8
83.8
85.0
90.6
(80.7 87.8)
(45.3 53.2)
(64.3 69.7)
(79.8 87.8)
(80.0 101)
(87.3 99.0)
1,472
112
254
309
351
446
55.3
36.6
46.6
53.5
57.7
64.3
(54.1 56.4)
(34.5 38.9)
(44.6 48.8)
(51.6 55.3)
(56.0 59.4)
(62.2 66.5)
37.6
28.2
35.9
36.7
41.6
46.4
(36.2 39.2)
(26.0 30.5)
(33.4 37.4)
(34.2 39.7)
(40.2 43.5)
(44.5 48.3)
55.6
37.1
45.5
53.1
57.7
64.8
(54.4 56.6)
(34.9 38.9)
(43.1 48.5)
(51.2 54.9)
(55.6 59.6)
(62.7 67.4)
79.8
48.1
63.7
76.1
79.1
87.9
(78.2 82.4)
(44.3 54.7)
(59.5 70.1)
(72.8 83.1)
(75.6 83.9)
(84.1 95.0)
1,501
119
245
405
332
400
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
9797
52.8
55.2
54.7
(51.8 53.8)
(54.1 56.4)
(53.8 55.6)
30.7
32.6
32.5
(29.8 31.6)
(31.8 33.5)
(31.8 33.2)
53.5
56.0
55.2
(52.2 54.9)
(54.7 57.3)
(54.2 56.1)
85.6
88.4
87.8
(83.9 87.2)
(86.6 91.6)
(85.6 90.5)
7,102
7,935
7,254
35 years
19992000
20012002
32.3
33.8
(31.6 33.1)
(33.1 34.6)
22.0
24.3
(19.0 23.1)
(16.5 25.5)
33.1
34.0
(31.5 34.6)
(33.1 35.2)
46.2
47.1
(41.1 66.3)
(44.3 50.3)
352
430
19992000
20012002
20052006
35.1
37.3
36.4
(34.5 35.6)
(36.2 38.5)
(35.6 37.2)
25.3
26.5
25.6
(23.6 26.1)
(25.8 27.4)
(24.3 26.9)
35.4
37.3
36.6
(35.0 35.8)
(36.2 39.0)
(35.9 37.3)
48.5
51.6
52.4
(46.1 52.3)
(50.1 54.0)
(49.1 54.3)
866
1,014
860
19992000
20012002
20052006
45.7
48.0
46.5
(44.7 46.6)
(47.1 48.9)
(45.4 47.7)
30.1
31.8
32.0
(29.1 30.9)
(30.4 33.3)
(30.6 33.0)
45.8
48.5
46.0
(45.0 46.9)
(47.6 49.3)
(44.6 47.5)
69.4
71.2
69.6
(66.9 71.8)
(69.0 74.2)
(66.9 73.1)
2,111
2,206
1,954
19992000
20012002
20052006
52.1
54.8
54.3
(50.8 53.4)
(53.3 56.3)
(53.3 55.3)
33.0
34.2
33.9
(31.1 34.3)
(32.6 35.3)
(32.2 35.1)
52.8
55.8
54.7
(51.2 54.5)
(54.4 57.5)
(53.5 55.6)
80.3
83.4
84.4
(77.9 83.0)
(80.9 86.6)
(81.9 87.9)
1,461
1,716
1,688
19992000
20012002
20052006
59.0
60.3
58.7
(57.6 60.6)
(59.2 61.5)
(57.7 59.7)
35.9
37.5
36.8
(34.2 38.1)
(34.8 39.9)
(36.0 38.0)
59.8
61.2
59.5
(57.9 61.5)
(59.8 62.7)
(58.1 60.4)
90.4
94.6
90.3
(86.4 96.8)
(90.3 97.8)
(87.2 94.3)
1,191
1,474
1,365
19992000
20012002
20052006
62.5
65.0
64.4
(61.1 64.0)
(63.6 66.5)
(62.8 66.1)
39.7
40.3
40.2
(36.3 41.9)
(38.0 41.4)
(38.2 43.0)
63.0
65.4
64.9
(61.3 65.0)
(64.1 67.4)
(63.1 67.0)
94.3
102
99.8
(90.1 99.5)
(98.6 108)
(96.2 102)
1,473
1,525
1,387
19992000
20012002
20052006
55.8
58.5
57.2
(54.4 57.3)
(57.2 59.8)
(56.3 58.2)
31.9
34.4
33.6
(30.1 33.8)
(33.4 35.5)
(32.7 34.8)
57.5
59.8
58.0
(55.8 58.8)
(58.0 61.7)
(57.1 59.0)
86.3
91.5
89.0
(84.6 90.6)
(88.7 93.7)
(86.5 93.0)
3,450
3,841
3,547
19992000
20012002
20052006
50.1
52.3
52.4
(49.1 51.1)
(51.1 53.5)
(51.3 53.5)
30.2
31.7
31.9
(28.7 31.2)
(30.9 32.4)
(31.2 32.6)
50.0
52.5
52.4
(48.8 51.0)
(51.0 53.9)
(50.8 53.8)
84.1
86.6
85.9
(81.2 87.0)
(84.0 88.3)
(83.3 88.7)
3,652
4,094
3,707
19992000
20012002
20052006
47.0
48.6
48.4
(46.1 47.8)
(47.2 50.0)
(47.3 49.5)
29.0
29.8
30.3
(28.0 29.7)
(28.8 30.7)
(29.3 31.2)
46.9
48.8
48.8
(45.5 48.3)
(47.4 50.4)
(46.8 50.2)
75.6
76.6
73.7
(73.6 79.0)
(73.4 82.1)
(71.9 77.0)
2,410
1,991
1,844
19992000
20012002
20052006
45.8
47.2
48.3
(44.2 47.4)
(46.1 48.3)
(47.3 49.3)
27.8
28.2
28.8
(26.4 28.3)
(27.4 28.9)
(27.6 29.8)
45.4
47.0
48.1
(43.1 47.6)
(45.3 48.6)
(47.0 49.5)
75.7
80.2
82.0
(72.5 81.1)
(77.3 85.7)
(78.4 85.5)
1,590
1,864
1,891
19992000
20012002
20052006
55.6
57.9
57.4
(54.2 57.1)
(56.4 59.5)
(56.4 58.4)
33.4
34.7
34.8
(31.2 34.7)
(33.1 36.2)
(33.0 36.2)
56.8
58.9
57.9
(55.0 58.2)
(56.8 60.7)
(56.8 59.0)
87.3
91.3
89.8
(85.4 90.5)
(88.9 93.5)
(87.6 93.3)
2,456
3,455
2,973
Age group
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
98
98
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
100
i
i
95th Percentile
i
i
i
i
80
i
i
i
i
i
60
i
i
i
40
70
50th Percentile
60
i
i
i
i
i
i
i
50
40
i
i
30
40
i
i
30
i
i
i
i
i
i
i
i
25
20
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
15
9900
0102
5th Percentile
35
NHW
(6+y)
9999
7,254
0.3
(0.1 0.5)
711,000
611 years
1219 years
2039 years
4059 years
60 years and older
860
1,954
1,688
1,365
1,387
1.0
(0.6 1.5)
231,000
Males
Females
3,547
3,707
0.2
(0.1 0.4)
317,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
1,844
1,891
2,973
0.5
0.2
(0.3 0.7)
(0.1 0.5)
145,000
386,000
Gender
Race/ethnicity
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
100
100
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,254
2.1
611 years
1219 years
2039 years
4059 years
60 years and older
860
1,954
1,688
1,365
1,387
Males
Females
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Gender
Race/ethnicity
(1.6 2.7)
5,573,000
1.1
2.7
4.8
(0.5 2.3)
(1.8 3.9)
(3.8 6.0)
847,000
2,182,000
2,301,000
3,547
3,707
2.5
1.7
(1.8 3.4)
(1.0 2.9)
3,265,000
2,306,000
1,844
1,891
2,973
0.5
1.1
2.6
(0.3 1.1)
(0.6 2.0)
(2.0 3.5)
129,000
348,000
4,752,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
101
101
7,102
7,935
7,254
0.1
0.3
0.3
19992000
20012002
352
430
19992000
20012002
20052006
866
1,014
860
1.0
1.0
19992000
20012002
20052006
2,111
2,206
1,954
19992000
20012002
20052006
1,461
1,716
1,688
19992000
20012002
20052006
1,191
1,474
1,365
19992000
20012002
20052006
1,473
1,525
1,387
19992000
20012002
20052006
3,450
3,841
3,547
0.1
0.4
(0.1 0.3)
(0.2 0.7)
179,000
456,000
19992000
20012002
20052006
3,652
4,094
3,707
0.1
0.2
0.2
(0.1 0.2)
(0.1 0.4)
(0.1 0.4)
181,000
242,000
317,000
19992000
20012002
20052006
2,410
1,991
1,844
0.4
(0.2 0.8)
75,000
19992000
20012002
20052006
1,590
1,864
1,891
0.5
0.7
0.5
(0.3 0.8)
(0.3 1.2)
(0.3 0.7)
153,000
201,000
145,000
19992000
20012002
20052006
2,456
3,455
2,973
0.2
0.2
(0.1 0.5)
(0.1 0.5)
398,000
386,000
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
(0.1 0.2)
(0.2 0.4)
(0.1 0.5)
360,000
698,000
711,000
(0.6 1.6)
(0.6 1.5)
243,000
231,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
102
102
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,102
7,935
7,254
1.3
2.0
2.1
19992000
20012002
352
430
19992000
20012002
20052006
866
1,014
860
19992000
20012002
20052006
2,111
2,206
1,954
19992000
20012002
20052006
1,461
1,716
1,688
0.6
1.1
(0.2 1.3)
(0.5 2.3)
19992000
20012002
20052006
1,191
1,474
1,365
2.4
2.9
2.7
(1.4 4.0)
(2.0 4.4)
(1.8 3.9)
1,688,000
2,222,000
2,182,000
19992000
20012002
20052006
1,473
1,525
1,387
3.2
5.9
4.8
(2.1 4.8)
(4.3 8.0)
(3.8 6.0)
1,381,000
2,628,000
2,301,000
19992000
20012002
20052006
3,450
3,841
3,547
1.4
2.4
2.5
(0.9 2.4)
(1.9 3.0)
(1.8 3.4)
1,741,000
3,013,000
3,265,000
19992000
20012002
20052006
3,652
4,094
3,707
1.2
1.7
1.7
(0.7 2.0)
(1.2 2.4)
(1.0 2.9)
1,570,000
2,226,000
2,306,000
19992000
20012002
20052006
2,410
1,991
1,844
0.5
(0.3 1.1)
129,000
19992000
20012002
20052006
1,590
1,864
1,891
1.2
1.7
1.1
(0.7 2.2)
(0.8 3.7)
(0.6 2.0)
376,000
519,000
348,000
19992000
20012002
20052006
2,456
3,455
2,973
1.7
2.4
2.6
(1.2 2.4)
(1.9 2.9)
(2.0 3.5)
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
(1.0 1.8)
(1.6 2.5)
(1.6 2.7)
3,312,000
5,242,000
5,573,000
437,000
847,000
2,962,000
4,296,000
4,752,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
103
103
104
104
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
1.85
2.04
2.17
2.15
2.07
2.15
1.90
2.13
2.14
2.14
2.11
(1.78 1.91)
(1.90 2.19)
(2.10 2.25)
(2.08 2.23)
(2.01 2.12)
(2.01 2.29)
(1.84 1.97)
(2.04 2.23)
(2.04 2.25)
(2.01 2.28)
(2.05 2.17)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.5th
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
Geometric mean
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
5th
1.78
2.03
2.17
2.14
2.01
2.14
1.83
2.18
2.12
2.04
2.08
(1.69 1.88)
(1.84 2.20)
(2.04 2.27)
(2.04 2.24)
(1.94 2.11)
(1.93 2.27)
(1.74 1.94)
(2.03 2.29)
(2.00 2.24)
(1.88 2.23)
(1.99 2.17)
50th
4.77
5.00
6.02
5.89
5.51
5.01
4.78
5.00
6.15
6.87
5.67
(4.40 5.18)
(4.65 5.76)
(5.60 6.49)
(5.50 6.32)
(4.96 6.12)
(4.70 5.81)
(4.51 5.37)
(4.67 5.36)
(5.46 6.80)
(6.04 8.01)
(5.35 6.03)
95th
5.69
6.36
7.82
7.26
7.45
6.18
6.19
6.31
7.58
8.80
(5.19 7.49)
(5.70 7.56)
(7.04 8.74)
(6.78 8.26)
(6.53 8.14)
(5.67 8.84)
(5.77 6.77)
(5.70 7.62)
(6.74 9.10)
(7.86 11.7)
(6.93 7.96)
97.5th
7.35
1,746
1,842
2,838
3,397
3,549
827
1,865
1,620
1,315
1,319
6,946
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
3
1
Females
Males
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
3
2
1
0
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
3
1
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
105
105
Geometric mean
10th
50th
90th
Sample
size
2.11
2.15
1.90
2.13
2.14
2.14
(2.05 2.17)
(2.01 2.29)
(1.84 1.97)
(2.04 2.23)
(2.04 2.25)
(2.01 2.28)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.08
2.14
1.83
2.18
2.12
2.04
(1.99 2.17)
(1.93 2.27)
(1.74 1.94)
(2.03 2.29)
(2.00 2.24)
(1.88 2.23)
4.40
4.19
3.79
4.16
4.57
4.99
(4.28 4.54)
(4.02 4.62)
(3.60 4.10)
(3.86 4.43)
(4.23 5.15)
(4.54 5.60)
6,946
827
1,865
1,620
1,315
1,319
2.15
2.26
1.93
2.24
2.15
2.14
(2.08 2.23)
(2.05 2.48)
(1.82 2.05)
(2.09 2.39)
(2.01 2.30)
(2.01 2.28)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.14
2.22
1.85
2.30
2.14
2.03
(2.04 2.24)
(2.02 2.36)
(1.72 2.02)
(2.14 2.43)
(2.01 2.27)
(1.87 2.25)
4.52
4.56
3.84
4.42
4.66
5.04
(4.39 4.69)
(4.13 5.45)
(3.55 4.26)
(4.04 4.69)
(4.29 5.53)
(4.47 5.60)
3,397
411
935
714
650
687
2.07
2.05
1.88
2.02
2.13
2.14
(2.01 2.12)
(1.86 2.25)
(1.80 1.95)
(1.94 2.11)
(2.03 2.24)
(1.97 2.33)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.01
2.03
1.82
2.03
2.10
2.05
(1.94 2.11)
(1.81 2.25)
(1.69 1.92)
(1.91 2.18)
(1.97 2.24)
(1.78 2.31)
4.29
4.02
3.69
3.87
4.48
4.95
(4.13 4.44)
(3.76 4.41)
(3.44 4.31)
(3.65 4.31)
(4.00 5.50)
(4.36 6.43)
3,549
416
930
906
665
632
Males
Females
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Geometric mean
10th
50th
90th
Sample
size
1.85
1.79
1.65
1.90
1.89
1.95
(1.78 1.91)
(1.67 1.91)
(1.56 1.74)
(1.77 2.04)
(1.78 2.02)
(1.78 2.14)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.78
1.68
1.62
1.87
1.81
1.79
(1.69 1.88)
(1.58 1.80)
(1.57 1.67)
(1.68 2.04)
(1.67 2.00)
(1.63 2.06)
3.84
3.66
3.11
3.94
4.08
4.57
(3.60 4.09)
(3.09 4.25)
(2.87 3.51)
(3.68 4.49)
(3.50 4.79)
(3.78 5.89)
1,746
275
614
432
233
192
1.91
1.73
1.69
1.99
2.05
1.86
(1.80 2.03)
(1.56 1.91)
(1.56 1.83)
(1.74 2.27)
(1.86 2.26)
(1.56 2.22)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.84
1.60
1.64
1.95
1.98
1.76
(1.69 2.00)
(1.51 1.79)
(1.56 1.75)
(1.67 2.27)
(1.55 2.44)
(1.35 2.41)
3.99
3.68
3.12
4.21
4.35
4.45
(3.70 4.70)
(2.85 5.04)
(2.70 3.94)
(3.82 5.31)
(3.76 5.44)
(3.55 5.43)
832
136
294
193
114
95
1.78
1.85
1.61
1.79
1.75
2.02
(1.70 1.85)
(1.70 2.02)
(1.52 1.70)
(1.63 1.98)
(1.63 1.88)
(1.77 2.32)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.72
1.76
1.60
1.77
1.72
1.79
(1.63 1.83)
(1.63 1.94)
(1.47 1.69)
(1.53 2.03)
(1.52 1.95)
(1.58 2.24)
3.56
3.64
3.09
3.56
3.52
4.59
(3.44 3.71)
(3.14 4.87)
(2.79 3.66)
(3.32 3.89)
(3.24 4.47)
(3.30 8.50)
914
139
320
239
119
97
Males
Females
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
106
106
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
2.04
2.49
2.03
2.12
1.96
1.77
(1.90 2.19)
(2.19 2.82)
(1.88 2.21)
(1.92 2.35)
(1.82 2.12)
(1.60 1.96)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.03
2.49
1.99
2.10
1.94
1.65
(1.84 2.20)
(2.13 3.01)
(1.84 2.23)
(1.91 2.27)
(1.73 2.21)
(1.44 1.89)
4.13
4.82
4.05
4.23
3.88
3.95
(3.85 4.48)
(4.58 5.44)
(3.58 4.59)
(3.81 4.67)
(3.59 4.61)
(3.26 4.67)
1,842
238
643
363
326
272
2.15
2.66
2.17
2.29
1.99
1.79
(1.99 2.32)
(2.34 3.03)
(1.98 2.38)
(2.05 2.56)
(1.80 2.21)
(1.59 2.01)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.16
2.71
2.13
2.28
2.12
1.62
(2.00 2.30)
(2.35 2.96)
(1.88 2.36)
(2.05 2.56)
(1.69 2.30)
(1.32 1.99)
4.45
5.34
4.49
4.45
3.84
4.64
(3.88 5.02)
(4.54 6.33)
(3.67 5.39)
(3.73 5.85)
(3.42 7.34)
(3.40 5.35)
921
127
330
168
153
143
1.95
2.32
1.90
1.99
1.94
1.76
(1.79 2.12)
(1.94 2.77)
(1.71 2.12)
(1.75 2.25)
(1.76 2.14)
(1.52 2.03)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.92
2.37
1.91
2.01
1.88
1.66
(1.74 2.14)
(1.87 2.87)
(1.65 2.19)
(1.73 2.24)
(1.69 2.11)
(1.43 2.02)
3.93
4.60
3.55
3.92
3.92
3.54
(3.80 4.22)
(4.24 5.12)
(3.39 4.26)
(3.70 4.67)
(3.61 4.47)
(3.07 4.22)
921
111
313
195
173
129
Males
Females
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
Geometric mean
10th
50th
90th
Sample
size
2.17
2.18
1.93
2.21
2.20
2.20
(2.10 2.25)
(1.97 2.41)
(1.84 2.03)
(2.07 2.36)
(2.08 2.33)
(2.05 2.37)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.17
2.16
1.85
2.30
2.21
2.12
(2.04 2.27)
(1.87 2.30)
(1.70 2.01)
(2.12 2.44)
(2.02 2.34)
(1.91 2.35)
4.54
4.19
3.92
4.32
4.66
5.16
(4.39 4.71)
(3.82 4.82)
(3.56 4.47)
(3.85 4.66)
(4.33 5.45)
(4.63 5.86)
2,838
224
475
676
658
805
2.22
2.28
1.94
2.35
2.21
2.20
(2.12 2.32)
(1.97 2.63)
(1.79 2.10)
(2.14 2.57)
(2.06 2.36)
(2.04 2.38)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.21
2.22
1.87
2.40
2.20
2.10
(2.08 2.30)
(1.95 2.61)
(1.68 2.10)
(2.22 2.59)
(2.02 2.35)
(1.89 2.36)
4.66
4.52
3.80
4.49
4.77
5.16
(4.45 4.99)
(3.80 5.92)
(3.40 4.67)
(4.09 5.04)
(4.35 6.02)
(4.50 5.79)
1,407
107
245
293
339
423
2.13
2.07
1.92
2.08
2.20
2.20
(2.05 2.21)
(1.77 2.43)
(1.81 2.04)
(1.94 2.23)
(2.06 2.34)
(1.99 2.42)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.13
2.10
1.81
2.21
2.21
2.15
(1.96 2.26)
(1.75 2.39)
(1.67 1.98)
(1.91 2.36)
(1.97 2.40)
(1.80 2.41)
4.41
4.05
3.98
4.07
4.54
5.15
(4.25 4.65)
(3.50 4.51)
(3.30 4.57)
(3.57 4.65)
(4.05 5.85)
(4.45 6.71)
1,431
117
230
383
319
382
Males
Females
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
107
107
1.23
1.92
2.11
(1.04 1.46)
(1.83 2.02)
(2.05 2.17)
< LOD
.690
< LOD
1.47
1.93
2.08
(1.27 1.70)
(1.85 2.01)
(1.99 2.17)
4.95
5.49
5.67
(4.58 5.83)
(5.16 5.86)
(5.35 6.03)
5,589
7,641
6,946
35 years
19992000
20012002
1.46
1.88
(1.16 1.84)
(1.71 2.06)
< LOD
.482
1.67
1.82
(1.33 1.97)
(1.69 2.02)
5.39
5.62
(4.82 8.78)
(4.79 8.77)
278
412
19992000
20012002
20052006
1.33
2.02
2.15
(1.07 1.67)
(1.90 2.15)
(2.01 2.29)
< LOD
.700
< LOD
(.462 .801)
1.64
2.15
2.14
(1.29 2.02)
(2.03 2.25)
(1.93 2.27)
5.75
5.32
5.01
(4.55 8.88)
(4.79 5.85)
(4.70 5.81)
651
967
827
19992000
20012002
20052006
1.17
1.71
1.90
(.963 1.41)
(1.61 1.80)
(1.84 1.97)
< LOD
.560
< LOD
(.500 .692)
1.41
1.77
1.83
(1.12 1.68)
(1.66 1.87)
(1.74 1.94)
4.11
4.21
4.78
(3.71 4.77)
(3.98 4.47)
(4.51 5.37)
1,620
2,122
1,865
19992000
20012002
20052006
1.14
1.91
2.13
(.928 1.39)
(1.77 2.06)
(2.04 2.23)
< LOD
.643
< LOD
(.543 .720)
1.40
1.91
2.18
(1.21 1.62)
(1.79 2.03)
(2.03 2.29)
4.58
5.14
5.00
(4.14 5.67)
(4.65 5.79)
(4.67 5.36)
1,201
1,655
1,620
19992000
20012002
20052006
1.30
1.99
2.14
(1.06 1.59)
(1.87 2.11)
(2.04 2.25)
< LOD
.623
< LOD
(.529 .698)
1.55
1.96
2.12
(1.30 1.84)
(1.89 2.06)
(2.00 2.24)
5.49
5.70
6.15
(4.61 6.83)
(5.19 6.53)
(5.46 6.80)
959
1,429
1,315
19992000
20012002
20052006
1.34
1.96
2.14
(1.11 1.62)
(1.82 2.11)
(2.01 2.28)
< LOD
.522
< LOD
(.453 .580)
1.54
1.91
2.04
(1.29 1.89)
(1.75 2.13)
(1.88 2.23)
5.78
6.79
6.87
(4.87 6.47)
(6.11 7.83)
(6.04 8.01)
1,158
1,468
1,319
1.38
2.01
2.15
(1.17 1.63)
(1.90 2.12)
(2.08 2.23)
< LOD
.636
< LOD
(.544 .687)
1.61
2.01
2.14
(1.40 1.82)
(1.91 2.12)
(2.04 2.24)
5.22
5.71
5.89
(4.65 5.94)
(5.31 6.20)
(5.50 6.32)
2,676
3,698
3,397
1.11
1.85
2.07
(.922 1.33)
(1.76 1.95)
(2.01 2.12)
< LOD
.582
< LOD
(.515 .695)
1.36
1.84
2.01
(1.16 1.61)
(1.75 1.92)
(1.94 2.11)
4.79
5.11
5.51
(4.47 5.80)
(4.78 5.68)
(4.96 6.12)
2,913
3,943
3,549
19992000
20012002
20052006
.759
1.62
1.85
(.635 .906)
(1.47 1.78)
(1.78 1.91)
< LOD
.503
< LOD
(.398 .575)
.945
1.65
1.78
(.808 1.14)
(1.50 1.85)
(1.69 1.88)
3.69
4.28
4.77
(3.32 4.35)
(3.95 4.80)
(4.40 5.18)
1,463
1,980
1,746
19992000
20012002
20052006
1.18
1.92
2.04
(.848 1.64)
(1.82 2.02)
(1.90 2.19)
< LOD
.628
< LOD
(.390 .709)
1.48
1.96
2.03
(1.07 1.99)
(1.88 2.06)
(1.84 2.20)
5.06
5.44
5.00
(4.41 5.81)
(4.71 6.44)
(4.65 5.76)
1,422
1,734
1,842
19992000
20012002
20052006
1.32
1.97
2.17
(1.08 1.60)
(1.87 2.08)
(2.10 2.25)
< LOD
.636
< LOD
(.584 .684)
1.57
1.95
2.17
(1.33 1.84)
(1.86 2.06)
(2.04 2.27)
5.12
5.57
6.02
(4.60 6.48)
(5.14 5.99)
(5.60 6.49)
2,121
3,318
2,838
Age group
611 years
1219 years
2039 years
4059 years
Gender
(.537 .696)
Females
19992000
20012002
20052006
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
108
108
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
(
(
(
(
(
(
2
2.5
50th Percentile
2.0
1.5
(
(
(
(
1.0
0.5
0.8
(
0.6
0.5
0.4
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
0.3
9900
0102
5th Percentile
0.7
NHW
(6+y)
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
109
109
110
110
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
*
*
*
*
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.5th
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
Geometric mean
5th
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
50th
.933
.896
1.50
1.40
1.25
1.33
.911
.947
1.35
1.93
1.31
(.792 1.19)
(.829 1.10)
(1.36 1.64)
(1.29 1.54)
(1.09 1.48)
(1.08 1.97)
(.743 1.14)
(.850 1.09)
(1.23 1.63)
(1.59 2.58)
(1.23 1.48)
95th
1.35
1.38
2.06
1.94
1.99
1.97
1.48
1.32
2.00
2.77
(1.08 2.07)
(1.10 1.71)
(1.93 2.36)
(1.86 2.05)
(1.62 2.34)
(1.65 4.08)
(1.18 2.00)
(1.14 1.76)
(1.68 2.31)
(2.26 3.58)
(1.79 2.09)
97.5th
1.95
1,739
1,699
2,747
3,276
3,422
792
1,801
1,555
1,262
1,288
6,698
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
No serum retinyl stearate figure for concentrations by age group is presented because the
geometric means were not calculated due to the proportion of results below the limit of
detection being too high for valid results (see Table 2.3.a.1).
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
111
111
Geometric mean
10th
50th
90th
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.894
.972
< LOD
< LOD
.944
1.32
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.964
1.03
< LOD
.813
.993
1.33
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.839
.896
< LOD
< LOD
.903
1.32
Males
Females
(.794 1.02)
(.730 1.21)
(.810 1.16)
(1.13 1.58)
(.871 1.08)
(< LOD 1.76)
(.709 .968)
(.842 1.17)
(1.16 1.53)
(.741 .960)
(< LOD 1.17)
(.764 1.21)
(1.06 1.74)
Sample
size
6,698
792
1,801
1,555
1,262
1,288
3,276
394
898
682
624
678
3,422
398
903
873
638
610
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Geometric mean
10th
50th
90th
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.766
.902
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.736
< LOD
< LOD
.700
.851
.780
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.02
Males
Females
Sample
size
1,739
272
604
428
238
197
832
135
290
190
118
99
907
137
314
238
120
98
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Estimate is subject to greater uncertainty due to small cell size.
112
112
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.781
.770
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.746
< LOD
< LOD
< LOD
.813
1.06
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.701
< LOD
Males
Females
Sample
size
1,699
219
597
322
301
260
849
118
300
152
141
138
850
101
297
170
160
122
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Estimate is subject to greater uncertainty due to small cell size.
Geometric mean
10th
50th
90th
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.01
1.06
< LOD
.727
1.00
1.40
2,747
212
465
660
627
783
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.09
1.09
.740
.927
1.07
1.39
(.967 1.18)
(< LOD 7.58)
(< LOD 1.05)
(.740 1.16)
(.862 1.24)
(1.19 1.65)
1,370
103
244
283
324
416
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.948
1.04
< LOD
< LOD
.953
1.41
(.855 1.07)
(.755 2.95)
1,377
109
221
377
303
367
Males
Females
(.932 1.10)
(.756 1.99)
Sample
size
(.798 1.31)
(1.08 2.01)
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Estimate is subject to greater uncertainty due to small cell size.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
113
113
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.12
1.08
1.31
(.983 1.44)
(.988 1.19)
(1.23 1.48)
4,148
7,690
6,698
35 years
19992000
20012002
*
*
< LOD
< LOD
< LOD
< LOD
2.43
1.75
(1.72 3.65)
(1.37 3.49)
212
416
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.74
1.14
1.33
(1.09 10.3)
(.964 1.34)
(1.08 1.97)
434
981
792
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.829
< LOD
.911
(.743 1.14)
1,194
2,145
1,801
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.928
.721
.947
(.651 1.36)
(.693 .893)
(.850 1.09)
872
1,658
1,555
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.32
1.15
1.35
(.944 2.40)
(1.04 1.46)
(1.23 1.63)
716
1,422
1,262
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.83
1.77
1.93
(1.39 2.90)
(1.52 2.08)
(1.59 2.58)
932
1,484
1,288
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.13
1.19
1.40
(.987 1.66)
(1.09 1.42)
(1.29 1.54)
2,008
3,710
3,276
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.10
.953
1.25
(.951 1.42)
(.856 1.09)
(1.09 1.48)
2,140
3,980
3,422
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.695
.587
.933
1,002
1,921
1,739
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.962
.733
.896
(.590 15.0)
(.619 .963)
(.829 1.10)
1,060
1,827
1,699
19992000
20012002
20052006
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
1.27
1.13
1.50
(1.00 1.81)
(1.02 1.30)
(1.36 1.64)
1,608
3,331
2,747
Age group
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Estimate is subject to greater uncertainty due to cell size.
114
114
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
15
10
0
10
50th Percentile
2
10
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
2
9900
0102
5th Percentile
NHW
(6+y)
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
115
115
116
116
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
1,010
933
1,140
1,060
1,120
820
770
1,020
1,230
1,400
1,090
(980 1,040)
(915 951)
(1,110 1,160)
(1,040 1,090)
(1,090 1,140)
(800 841)
(757 783)
(998 1,040)
(1,190 1,260)
(1,360 1,440)
(1,070 1,120)
Geometric mean
581
548
584
559
596
546
497
590
702
704
(553 599)
(530 559)
(566 596)
(543 575)
(585 612)
(518 573)
(466 519)
(559 619)
(656 721)
(611 750)
(563 587)
2.5th
578
623
588
643
610
653
583
527
645
749
783
631
(602 637)
(581 601)
(624 658)
(594 625)
(639 664)
(563 601)
(516 541)
(621 668)
(724 769)
(733 835)
(620 642)
5th
976
903
1,110
1,030
1,080
806
759
1,000
1,200
1,390
1,060
(945 1,000)
(884 918)
(1,080 1,140)
(1,010 1,070)
(1,050 1,100)
(788 826)
(749 767)
(980 1,020)
(1,160 1,240)
(1,330 1,430)
(1,030 1,080)
50th
1,790
1,660
2,170
2,010
2,170
1,200
1,160
1,730
2,210
2,600
2,090
(1,750 1,870)
(1,560 1,750)
(2,090 2,270)
(1,930 2,090)
(2,080 2,260)
(1,120 1,370)
(1,130 1,200)
(1,620 1,900)
(2,080 2,400)
(2,510 2,660)
(2,010 2,180)
95th
2,120
1,800
2,520
2,360
2,510
1,360
1,320
1,940
2,510
2,900
2,460
(1,960 2,330)
(1,740 2,080)
(2,420 2,690)
(2,160 2,520)
(2,370 2,660)
(1,230 1,510)
(1,240 1,450)
(1,810 2,380)
(2,260 3,110)
(2,710 3,130)
(2,310 2,600)
97.5th
1,844
1,891
2,973
3,547
3,707
860
1,954
1,688
1,365
1,387
7,254
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
1500
Mexican Americans
500
1000
Females
Males
Serum vitamin E
(g/dL)
2000
Overall
611
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
500
1000
1500
2000
NonHispanic Blacks
1219
Serum vitamin E
(g/dL)
1219
611
1219
4059
60+
611
1219
4059
60+
Males
1500
2000
Females
2039
500
1000
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum vitamin E
(g/dL)
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
117
117
Geometric mean
10th
50th
90th
Sample
size
1,090
820
770
1,020
1,230
1,400
(1,070 1,120)
(800 841)
(757 783)
(998 1,040)
(1,190 1,260)
(1,360 1,440)
702
629
578
710
824
897
(686 716)
(621 638)
(557 587)
(683 727)
(799 848)
(828 949)
1,060
806
759
1,000
1,200
1,390
(1,030 1,080)
(788 826)
(749 767)
(980 1,020)
(1,160 1,240)
(1,330 1,430)
1,790
1,070
1,050
1,520
1,870
2,190
(1,730 1,840)
(1,040 1,180)
(1,000 1,070)
(1,410 1,610)
(1,790 2,040)
(2,130 2,270)
7,254
860
1,954
1,688
1,365
1,387
1,060
817
753
1,030
1,210
1,300
(1,040 1,090)
(789 847)
(739 768)
(1,010 1,050)
(1,180 1,250)
(1,230 1,370)
682
629
553
699
798
827
(664 704)
(593 642)
(527 580)
(671 728)
(767 848)
(762 887)
1,030
807
747
1,010
1,190
1,290
(1,010 1,070)
(766 843)
(733 759)
(984 1,030)
(1,160 1,240)
(1,220 1,330)
1,730
1,070
1,030
1,570
1,820
2,070
(1,640 1,770)
(1,030 1,180)
(986 1,070)
(1,440 1,730)
(1,740 1,950)
(1,950 2,310)
3,547
427
980
738
673
729
1,120
823
788
1,010
1,240
1,490
(1,090 1,140)
(792 856)
(772 804)
(981 1,040)
(1,200 1,290)
(1,440 1,540)
717
628
594
717
841
966
(705 723)
(608 647)
(570 611)
(679 738)
(818 860)
(926 987)
1,080
805
771
997
1,210
1,500
(1,050 1,100)
(784 837)
(755 788)
(956 1,030)
(1,160 1,240)
(1,430 1,540)
1,840
1,090
1,050
1,470
1,920
2,260
(1,790 1,910)
(1,020 1,230)
(991 1,120)
(1,360 1,580)
(1,820 2,120)
(2,190 2,470)
3,707
433
974
950
692
658
Males
Females
Geometric mean
10th
50th
90th
Sample
size
1,010
793
760
1,020
1,240
1,360
(980 1,040)
(770 816)
(740 781)
(991 1,060)
(1,200 1,280)
(1,250 1,470)
671
623
587
727
836
913
(656 695)
(599 644)
(578 597)
(676 755)
(808 861)
(816 996)
976
779
750
997
1,220
1,300
(945 1,000)
(755 800)
(723 773)
(968 1,020)
(1,160 1,270)
(1,240 1,370)
1,580
1,010
991
1,520
1,790
2,000
(1,530 1,630)
(977 1,110)
(970 1,050)
(1,420 1,640)
(1,730 1,950)
(1,720 3,120)
1,844
295
646
449
246
208
1,010
786
748
1,040
1,270
1,260
(970 1,050)
(762 811)
(718 778)
(1,010 1,080)
(1,190 1,350)
(1,140 1,390)
671
622
591
753
863
845
(640 701)
(598 643)
(573 603)
(703 772)
(814 908)
(650 931)
972
763
733
990
1,260
1,240
(925 999)
(745 802)
(690 775)
(967 1,020)
(1,140 1,350)
(1,100 1,340)
1,570
989
978
1,590
1,670
1,970
(1,510 1,610)
(962 1,060)
(930 1,060)
(1,460 1,700)
(1,610 2,030)
(1,570 3,130)
883
145
313
198
122
105
1,010
800
774
1,000
1,210
1,450
(984 1,030)
(763 838)
(750 798)
(955 1,050)
(1,170 1,260)
(1,300 1,610)
670
625
583
700
808
1,000
(649 696)
(514 658)
(570 597)
(634 742)
(778 859)
(872 1,090)
985
787
763
1,000
1,200
1,410
(949 1,020)
(760 799)
(748 784)
(947 1,060)
(1,110 1,240)
(1,240 1,540)
1,610
1,050
1,020
1,490
1,840
2,040
(1,530 1,670)
(958 1,240)
(960 1,090)
(1,340 1,650)
(1,710 2,100)
(1,720 4,610)
961
150
333
251
124
103
Males
Females
118
118
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
933
771
731
926
1,040
1,110
(915 951)
(743 801)
(715 748)
(896 957)
(1,010 1,070)
(1,060 1,160)
644
587
575
665
736
752
(630 656)
(550 634)
(551 591)
(620 686)
(688 779)
(709 791)
903
762
727
893
1,010
1,080
(884 918)
(735 800)
(717 736)
(865 933)
(998 1,050)
(993 1,150)
1,400
1,010
945
1,340
1,540
1,680
(1,360 1,470)
(941 1,090)
(913 990)
(1,250 1,450)
(1,420 1,670)
(1,560 1,780)
1,891
240
665
368
335
283
915
768
732
937
1,010
1,050
(897 933)
(740 799)
(714 751)
(888 989)
(972 1,050)
(1,000 1,100)
636
588
582
650
718
726
(618 651)
(558 634)
(558 606)
(603 687)
(632 743)
(580 770)
882
752
727
896
988
980
(870 895)
(726 799)
(712 737)
(862 939)
(960 1,020)
(894 1,080)
1,390
1,030
940
1,400
1,520
1,680
(1,310 1,460)
(928 1,110)
(904 981)
(1,240 1,670)
(1,390 1,640)
(1,410 2,250)
949
128
343
170
156
152
949
775
731
917
1,070
1,150
(923 976)
(735 817)
(706 757)
(893 941)
(1,030 1,110)
(1,080 1,230)
651
579
567
677
761
774
(638 673)
(400 643)
(517 596)
(613 704)
(707 808)
(650 848)
916
776
726
892
1,040
1,130
(897 944)
(746 803)
(712 750)
(862 925)
(1,000 1,110)
(1,040 1,230)
1,450
1,000
957
1,270
1,540
1,670
(1,350 1,560)
(931 1,140)
(906 1,050)
(1,190 1,490)
(1,400 1,740)
(1,560 1,770)
942
112
322
198
179
131
Males
Females
Geometric mean
10th
50th
90th
Sample
size
1,140
840
779
1,040
1,260
1,430
(1,110 1,160)
(815 866)
(761 797)
(1,010 1,070)
(1,220 1,300)
(1,390 1,480)
718
627
579
711
846
919
(706 729)
(612 642)
(544 589)
(671 741)
(817 866)
(856 976)
1,110
826
765
1,030
1,230
1,430
(1,080 1,140)
(805 854)
(751 784)
(1,000 1,060)
(1,190 1,260)
(1,390 1,480)
1,870
1,120
1,060
1,550
1,910
2,230
(1,810 1,940)
(1,060 1,260)
(1,010 1,140)
(1,410 1,710)
(1,800 2,100)
(2,170 2,330)
2,973
231
499
714
683
846
1,100
839
757
1,040
1,240
1,330
(1,070 1,130)
(801 879)
(737 778)
(1,020 1,070)
(1,200 1,270)
(1,240 1,420)
703
629
542
687
818
862
(671 725)
(562 680)
(523 572)
(640 735)
(769 865)
(733 930)
1,080
830
754
1,030
1,230
1,300
(1,050 1,120)
(791 880)
(730 783)
(1,020 1,060)
(1,180 1,260)
(1,250 1,360)
1,770
1,080
1,060
1,590
1,840
2,100
(1,740 1,850)
(1,030 1,300)
(1,000 1,110)
(1,430 1,770)
(1,750 2,040)
(1,970 2,460)
1,472
112
254
309
351
446
1,170
841
803
1,040
1,270
1,530
(1,150 1,200)
(792 892)
(780 827)
(1,000 1,080)
(1,230 1,320)
(1,480 1,590)
727
624
601
720
862
985
(718 746)
(597 656)
(562 641)
(699 754)
(842 894)
(964 1,020)
1,140
819
779
1,020
1,240
1,530
(1,100 1,170)
(774 878)
(750 805)
(978 1,060)
(1,190 1,280)
(1,470 1,590)
1,930
1,160
1,060
1,510
2,000
2,320
(1,870 2,050)
(1,050 1,470)
(985 1,200)
(1,360 1,630)
(1,850 2,190)
(2,240 2,500)
1,501
119
245
405
332
400
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
119
119
1,070
1,110
1,090
(1,040 1,110)
(1,090 1,140)
(1,070 1,120)
597
637
631
(575 612)
(623 649)
(620 642)
1,010
1,050
1,060
(986 1,040)
(1,010 1,090)
(1,030 1,080)
2,350
2,380
2,090
(2,280 2,500)
(2,260 2,520)
(2,010 2,180)
7,054
7,935
7,254
35 years
19992000
20012002
785
814
(752 820)
(780 850)
559
577
(514 585)
(553 601)
772
796
(734 829)
(760 824)
1,160
1,200
(1,120 1,400)
(1,090 1,670)
347
430
19992000
20012002
20052006
783
804
820
(754 814)
(788 821)
(800 841)
545
576
583
(519 557)
(560 591)
(563 601)
781
798
806
(749 824)
(780 819)
(788 826)
1,130
1,140
1,200
(1,090 1,210)
(1,090 1,220)
(1,120 1,370)
859
1,014
860
19992000
20012002
20052006
736
782
770
(717 756)
(768 796)
(757 783)
513
550
527
(491 530)
(540 559)
(516 541)
729
771
759
(712 744)
(761 786)
(749 767)
1,100
1,170
1,160
(1,020 1,240)
(1,110 1,280)
(1,130 1,200)
2,108
2,206
1,954
19992000
20012002
20052006
973
1,010
1,020
(952 995)
(987 1,030)
(998 1,040)
615
646
645
(590 630)
(627 661)
(621 668)
938
979
1,000
(911 972)
(960 1,000)
(980 1,020)
1,750
1,720
1,730
(1,640 1,860)
(1,620 1,880)
(1,620 1,900)
1,452
1,716
1,688
19992000
20012002
20052006
1,300
1,310
1,230
(1,250 1,360)
(1,270 1,340)
(1,190 1,260)
753
776
749
(716 791)
(751 793)
(724 769)
1,230
1,260
1,200
(1,200 1,280)
(1,220 1,300)
(1,160 1,240)
2,670
2,530
2,210
(2,470 2,940)
(2,380 3,030)
(2,080 2,400)
1,181
1,474
1,365
19992000
20012002
20052006
1,510
1,540
1,400
(1,470 1,560)
(1,490 1,590)
(1,360 1,440)
788
830
783
(749 825)
(763 869)
(733 835)
1,450
1,500
1,390
(1,390 1,510)
(1,440 1,550)
(1,330 1,430)
3,020
3,290
2,600
(2,920 3,290)
(3,030 3,540)
(2,510 2,660)
1,454
1,525
1,387
19992000
20012002
20052006
1,050
1,090
1,060
(1,010 1,090)
(1,060 1,130)
(1,040 1,090)
580
623
610
(557 604)
(607 646)
(594 625)
993
1,030
1,030
(976 1,020)
(986 1,080)
(1,010 1,070)
2,280
2,300
2,010
(2,130 2,470)
(2,160 2,470)
(1,930 2,090)
3,426
3,841
3,547
19992000
20012002
20052006
1,100
1,130
1,120
(1,070 1,140)
(1,110 1,150)
(1,090 1,140)
605
646
653
(580 627)
(629 660)
(639 664)
1,030
1,060
1,080
(990 1,070)
(1,040 1,100)
(1,050 1,100)
2,450
2,480
2,170
(2,300 2,690)
(2,280 2,700)
(2,080 2,260)
3,628
4,094
3,707
19992000
20012002
20052006
962
994
1,010
(932 994)
(954 1,040)
(980 1,040)
572
606
623
(558 587)
(584 625)
(602 637)
918
949
976
(895 947)
(917 979)
(945 1,000)
1,810
1,810
1,790
(1,740 2,010)
(1,690 2,080)
(1,750 1,870)
2,410
1,991
1,844
19992000
20012002
20052006
904
930
933
(869 941)
(907 953)
(915 951)
566
601
588
(539 580)
(573 617)
(581 601)
869
897
903
(835 910)
(883 915)
(884 918)
1,700
1,690
1,660
(1,620 1,910)
(1,540 1,940)
(1,560 1,750)
1,584
1,864
1,891
19992000
20012002
20052006
1,130
1,160
1,140
(1,100 1,170)
(1,130 1,200)
(1,110 1,160)
618
653
643
(600 634)
(626 674)
(624 658)
1,060
1,110
1,110
(1,040 1,100)
(1,060 1,150)
(1,080 1,140)
2,540
2,510
2,170
(2,380 2,720)
(2,380 2,690)
(2,090 2,270)
2,414
3,455
2,973
Age group
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
120
120
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3000
95th Percentile
2500
2000
1500
1000
1200
50th Percentile
1000
800
600
800
600
500
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
400
9900
0102
5th Percentile
700
NHW
(6+y)
121
121
7,254
0.7
(0.5 0.9)
611 years
1219 years
2039 years
4059 years
60 years and older
860
1,954
1,688
1,365
1,387
0.9
2.6
0.3
0.4
(0.4 2.0)
(1.6 4.3)
(0.1 0.6)
(0.3 0.7)
Males
Females
3,547
3,707
0.9
0.5
(0.6 1.2)
(0.3 0.8)
1,110,000
725,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
1,844
1,891
2,973
1.2
0.6
(0.9 1.7)
(0.4 0.8)
396,000
1,059,000
Gender
Race/ethnicity
1,835,000
221,000
885,000
237,000
209,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
122
122
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,054
7,935
7,254
1.0
0.4
0.7
19992000
20012002
347
430
19992000
20012002
20052006
859
1,014
860
2.0
0.9
(0.4 2.0)
19992000
20012002
20052006
2,108
2,206
1,954
3.8
1.6
2.6
(2.1 6.8)
(1.0 2.6)
(1.6 4.3)
19992000
20012002
20052006
1,452
1,716
1,688
0.9
(0.5 1.8)
730,000
19992000
20012002
20052006
1,181
1,474
1,365
0.1
0.3
(0.1 0.2)
(0.1 0.6)
80,000
237,000
19992000
20012002
20052006
1,454
1,525
1,387
0.4
(0.3 0.7)
209,000
19992000
20012002
20052006
3,426
3,841
3,547
1.4
0.6
0.9
(0.8 2.3)
(0.4 1.0)
(0.6 1.2)
1,660,000
781,000
1,110,000
19992000
20012002
20052006
3,628
4,094
3,707
0.7
0.2
0.5
(0.4 1.1)
(0.1 0.5)
(0.3 0.8)
895,000
325,000
725,000
19992000
20012002
20052006
2,410
1,991
1,844
1.3
0.7
(0.9 1.8)
(0.4 1.5)
227,000
156,000
19992000
20012002
20052006
1,584
1,864
1,891
1.7
0.7
1.2
(0.9 3.2)
(0.4 1.1)
(0.9 1.7)
520,000
207,000
396,000
19992000
20012002
20052006
2,414
3,455
2,973
0.8
0.3
0.6
(0.5 1.3)
(0.2 0.5)
(0.4 0.8)
1,491,000
556,000
1,059,000
Age group
35 years
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
(0.7 1.6)
(0.3 0.6)
(0.5 0.9)
2,558,000
1,108,000
1,835,000
(1.0 4.1)
492,000
221,000
1,202,000
509,000
885,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
123
123
124
124
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
204
214
182
192
184
182
179
194
201
165
188
(192 217)
(198 231)
(173 191)
(184 200)
(175 194)
(171 193)
(171 188)
(184 205)
(192 212)
(154 177)
(180 196)
Geometric mean
80.4
70.6
51.2
54.9
52.4
68.1
75.5
65.4
53.0
45.1
53.5
(64.2 86.3)
(52.2 85.5)
(46.7 55.0)
(48.6 63.3)
(49.4 58.5)
(55.2 85.2)
(62.0 81.8)
(50.6 76.7)
(46.5 61.2)
(41.4 49.8)
(49.6 59.9)
2.5th
93.8
92.0
65.1
74.5
67.7
91.5
89.0
81.9
69.0
52.4
70.4
(84.0 102)
(67.4 106)
(57.4 72.3)
(62.4 80.8)
(60.1 73.5)
(71.3 99.2)
(79.8 93.8)
(75.3 93.8)
(56.1 80.0)
(49.7 57.5)
(62.9 75.4)
5th
209
219
190
198
194
179
184
200
213
176
196
(195 222)
(204 235)
(179 200)
(189 206)
(183 203)
(169 193)
(175 194)
(192 209)
(203 221)
(161 192)
(187 204)
50th
437
429
423
434
419
353
324
423
452
422
424
(390 503)
(408 488)
(407 445)
(411 471)
(400 441)
(333 390)
(311 343)
(401 460)
(437 498)
(403 462)
(408 446)
95th
504
509
485
505
464
392
376
489
545
486
489
(463 585)
(457 550)
(454 531)
(478 564)
(444 497)
(367 455)
(344 413)
(447 553)
(492 604)
(461 539)
(464 519)
97.5th
1,841
1,865
2,965
3,528
3,689
858
1,942
1,675
1,358
1,384
7,217
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
300
Overall
Mexican Americans
100
200
Females
Males
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
100
200
300
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
300
Females
2039
4059
60+
Males
100
200
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum gammatocopherol
(g/dL)
Serum gammatocopherol
(g/dL)
Serum gammatocopherol
(g/dL)
Geometric mean (95% confidence interval), National Health and Nutrition Examination Survey, 20052006
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
125
125
Geometric mean
10th
50th
90th
Sample
size
188
182
179
194
201
165
(180 196)
(171 193)
(171 188)
(184 205)
(192 212)
(154 177)
93.2
106
106
106
95.2
68.6
(86.8 98.0)
(102 111)
(98.1 114)
(94.7 114)
(84.4 102)
(60.9 73.4)
196
179
184
200
213
176
(187 204)
(169 193)
(175 194)
(192 209)
(203 221)
(161 192)
361
311
288
353
400
358
(347 385)
(298 341)
(276 304)
(330 393)
(376 423)
(340 397)
7,217
858
1,942
1,675
1,358
1,384
192
177
173
202
207
171
(184 200)
(166 189)
(162 184)
(193 211)
(194 221)
(157 185)
98.7
105
103
113
99.0
73.7
(89.3 107)
(94.0 109)
(89.6 114)
(105 119)
(86.0 113)
(66.9 77.2)
198
176
177
203
215
184
(189 206)
(163 189)
(168 188)
(194 215)
(202 230)
(159 204)
359
304
284
386
403
354
(349 389)
(276 349)
(266 306)
(349 414)
(365 442)
(336 396)
3,528
425
974
732
669
728
184
187
187
187
197
161
(175 194)
(174 201)
(177 197)
(173 202)
(186 208)
(148 175)
88.2
110
110
97.2
90.5
63.9
(80.0 93.8)
(93.6 122)
(101 119)
(79.9 110)
(75.5 99.0)
(53.9 72.6)
194
183
191
196
207
168
(183 203)
(169 199)
(184 201)
(180 207)
(195 223)
(155 188)
362
323
292
331
398
375
(338 388)
(299 346)
(274 313)
(312 383)
(377 423)
(328 405)
3,689
433
968
943
689
656
Males
Females
Geometric mean
10th
50th
90th
Sample
size
204
199
189
203
218
210
(192 217)
(178 221)
(179 200)
(190 217)
(202 237)
(196 225)
113
114
115
111
114
99.7
(106 117)
(91.6 122)
(106 124)
(107 116)
(91.7 125)
(90.1 117)
209
202
197
209
226
211
(195 222)
(181 234)
(183 207)
(190 223)
(213 240)
(194 224)
363
323
292
366
410
406
(343 403)
(303 388)
(279 316)
(333 429)
(357 478)
(365 464)
1,841
293
645
449
246
208
206
196
180
207
226
213
(196 216)
(175 219)
(169 191)
(195 221)
(199 256)
(187 242)
114
116
109
112
118
100
(109 118)
(90.6 128)
(97.9 115)
(107 118)
(96.4 141)
(83.3 119)
210
189
187
216
227
205
(193 224)
(171 221)
(166 208)
(191 228)
(201 265)
(182 266)
363
329
282
375
376
412
(339 417)
(290 448)
(264 310)
(316 522)
(345 582)
(353 496)
881
143
313
198
122
105
202
201
199
197
211
208
(185 220)
(171 237)
(187 213)
(177 219)
(187 237)
(188 229)
112
113
128
109
103
98.8
(96.2 120)
(80.8 128)
(113 137)
(93.8 118)
(61.5 121)
(85.1 120)
207
219
202
202
223
213
(194 221)
(172 262)
(191 212)
(180 219)
(184 259)
(192 224)
363
322
308
362
423
398
(334 407)
(303 373)
(286 375)
(315 443)
(351 515)
(315 506)
960
150
332
251
124
103
Males
Females
126
126
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
214
198
197
213
221
231
(198 231)
(183 214)
(180 215)
(196 231)
(198 247)
(204 261)
119
128
126
114
115
109
(98.4 135)
(96.7 141)
(105 142)
(93.5 137)
(72.3 140)
(60.6 139)
219
198
198
216
233
255
(204 235)
(189 210)
(180 215)
(202 231)
(208 254)
(216 286)
383
317
308
379
404
413
(357 407)
(291 360)
(279 338)
(334 420)
(378 476)
(392 466)
1,865
240
654
359
331
281
209
191
192
218
209
223
(192 227)
(171 213)
(176 210)
(197 241)
(182 241)
(193 259)
120
116
127
119
109
122
(102 136)
(69.0 142)
(111 141)
(101 136)
(71.2 141)
(53.9 147)
210
193
187
220
213
234
(195 225)
(182 205)
(170 208)
(195 240)
(187 239)
(202 276)
362
297
302
386
401
393
(335 402)
(263 360)
(278 335)
(326 500)
(311 526)
(341 498)
935
128
337
166
153
151
218
205
202
209
231
236
(203 234)
(191 221)
(183 223)
(188 231)
(210 255)
(207 270)
116
131
123
110
116
103
(93.3 134)
(99.5 143)
(98.5 147)
(81.8 141)
(72.3 134)
(54.5 145)
228
204
205
213
249
261
(213 242)
(189 229)
(195 218)
(195 236)
(217 285)
(219 299)
396
327
314
377
404
448
(375 410)
(292 433)
(279 354)
(329 426)
(399 443)
(393 505)
930
112
317
193
178
130
Males
Females
Geometric mean
10th
50th
90th
Sample
size
182
175
174
191
196
158
(173 191)
(159 192)
(165 184)
(178 205)
(184 207)
(148 169)
86.4
105
102
105
91.6
65.9
(79.6 92.0)
(99.7 109)
(90.8 108)
(83.6 116)
(80.3 97.8)
(59.4 72.1)
190
170
179
196
207
168
(179 200)
(157 191)
(171 188)
(183 207)
(195 220)
(154 183)
356
304
284
349
396
353
(340 387)
(272 349)
(274 301)
(320 401)
(368 424)
(326 392)
2,965
231
499
710
680
845
187
174
167
200
201
165
(178 197)
(153 197)
(155 180)
(190 210)
(185 218)
(151 180)
94.7
105
95.0
117
95.5
71.6
(81.7 104)
(82.6 111)
(76.7 113)
(105 126)
(80.3 106)
(62.2 76.5)
194
170
173
201
214
177
(184 204)
(150 192)
(163 181)
(188 212)
(195 230)
(150 199)
355
307
280
370
398
351
(344 388)
(269 378)
(250 314)
(346 414)
(350 448)
(331 380)
1,469
112
254
307
350
446
177
177
182
183
190
153
(167 188)
(160 195)
(171 195)
(163 204)
(178 204)
(141 165)
79.9
104
103
92.8
83.6
61.1
(73.8 87.5)
(86.4 114)
(89.6 118)
(71.4 110)
(68.1 98.3)
(53.5 69.6)
186
171
187
191
203
161
(173 197)
(155 197)
(175 200)
(169 210)
(186 217)
(148 174)
359
300
289
323
392
357
(324 391)
(260 349)
(270 312)
(296 403)
(373 427)
(319 400)
1,496
119
245
403
330
399
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
127
127
199
199
188
(184 216)
(191 207)
(180 196)
65.1
67.1
70.4
(58.2 71.7)
(59.4 73.8)
(62.9 75.4)
215
212
196
(197 230)
(204 220)
(187 204)
464
461
424
(432 529)
(436 485)
(408 446)
6,129
7,879
7,217
35 years
19992000
20012002
170
181
(140 206)
(170 193)
50.0
63.3
(16.2 90.8)
(52.2 82.2)
180
194
(158 200)
(178 205)
363
365
(308 455)
(342 430)
301
429
19992000
20012002
20052006
202
211
182
(183 223)
(203 219)
(171 193)
93.3
102
91.5
(72.3 107)
(95.4 109)
(71.3 99.2)
213
218
179
(184 231)
(211 227)
(169 193)
407
380
353
(356 569)
(361 414)
(333 390)
725
1,005
858
19992000
20012002
20052006
197
197
179
(183 211)
(190 205)
(171 188)
99.0
99.4
89.0
(80.4 112)
(90.2 107)
(79.8 93.8)
198
201
184
(186 214)
(191 209)
(175 194)
372
368
324
(363 389)
(346 391)
(311 343)
1,821
2,188
1,942
19992000
20012002
20052006
205
206
194
(189 222)
(197 216)
(184 205)
75.6
85.6
81.9
(60.5 87.3)
(73.5 95.3)
(75.3 93.8)
220
217
200
(199 237)
(205 227)
(192 209)
438
445
423
(414 477)
(425 474)
(401 460)
1,299
1,706
1,675
19992000
20012002
20052006
208
204
201
(185 232)
(192 217)
(192 212)
59.8
60.4
69.0
(51.9 70.0)
(52.2 68.3)
(56.1 80.0)
231
221
213
(204 253)
(208 238)
(203 221)
549
507
452
(507 631)
(463 576)
(437 498)
1,028
1,463
1,358
19992000
20012002
20052006
178
172
165
(160 197)
(162 184)
(154 177)
47.6
48.2
52.4
(42.9 54.4)
(43.8 52.0)
(49.7 57.5)
196
185
176
(171 216)
(170 201)
(161 192)
496
497
422
(443 573)
(469 534)
(403 462)
1,256
1,517
1,384
19992000
20012002
20052006
199
202
192
(184 217)
(193 211)
(184 200)
65.3
66.5
74.5
(55.9 74.7)
(56.0 77.1)
(62.4 80.8)
213
213
198
(197 230)
(207 222)
(189 206)
462
472
434
(426 532)
(445 499)
(411 471)
2,974
3,815
3,528
19992000
20012002
20052006
200
196
184
(184 217)
(187 205)
(175 194)
64.8
67.6
67.7
(57.6 71.8)
(60.6 74.7)
(60.1 73.5)
217
210
194
(196 232)
(200 220)
(183 203)
468
447
419
(433 536)
(420 483)
(400 441)
3,155
4,064
3,689
19992000
20012002
20052006
222
198
204
(210 235)
(190 206)
(192 217)
104
89.8
93.8
(89.1 113)
(80.5 92.6)
(84.0 102)
225
203
209
(213 236)
(190 214)
(195 222)
468
422
437
(414 504)
(390 458)
(390 503)
1,772
1,987
1,841
19992000
20012002
20052006
213
235
214
(200 226)
(222 248)
(198 231)
94.5
107
92.0
(73.1 104)
(83.5 118)
(67.4 106)
217
248
219
(201 238)
(233 261)
(204 235)
437
450
429
(417 473)
(426 478)
(408 488)
1,515
1,843
1,865
19992000
20012002
20052006
198
193
182
(179 219)
(183 205)
(173 191)
61.3
60.4
65.1
(52.8 70.1)
(51.4 68.0)
(57.4 72.3)
217
209
190
(192 234)
(198 220)
(179 200)
477
472
423
(439 542)
(442 495)
(407 445)
2,240
3,426
2,965
Age group
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
128
128
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
600
500
400
300
50th Percentile
300
250
200
150
100
50
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
9900
0102
0506
0
9900
0102
5th Percentile
150
NHW
(6+y)
129
129
130
130
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2.99
1.98
2.80
2.37
3.18
2.64
1.85
2.48
3.15
3.42
2.76
(2.79 3.21)
(1.74 2.26)
(2.60 3.02)
(2.20 2.55)
(2.89 3.50)
(2.32 3.01)
(1.69 2.03)
(2.24 2.74)
(2.85 3.47)
(3.05 3.83)
(2.54 2.99)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.5th
.824
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.711
< LOD
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
Geometric mean
(.749 .889)
5th
2.87
1.71
2.67
2.23
3.01
2.59
1.72
2.36
3.01
3.33
2.63
(2.61 3.21)
(1.49 1.99)
(2.47 2.89)
(2.06 2.39)
(2.74 3.32)
(2.31 2.90)
(1.53 1.91)
(2.06 2.69)
(2.72 3.36)
(2.86 3.86)
(2.40 2.84)
50th
10.8
11.0
14.4
11.5
16.4
11.5
7.91
11.3
17.0
17.0
14.1
(10.5 12.5)
(8.83 14.8)
(12.8 16.7)
(9.92 13.9)
(14.6 18.4)
(9.30 15.1)
(6.65 10.2)
(10.1 14.7)
(14.5 21.9)
(14.0 19.8)
(12.4 16.5)
95th
14.8
15.2
20.2
16.1
23.9
15.7
10.8
16.3
27.1
21.6
(13.9 16.6)
(12.4 33.1)
(18.1 24.2)
(13.2 20.9)
(19.4 30.0)
(11.6 34.7)
(8.96 15.2)
(12.7 23.6)
(20.3 35.9)
(19.3 25.9)
(17.6 23.7)
97.5th
19.5
1,844
1,890
2,966
3,544
3,702
860
1,950
1,684
1,365
1,387
7,246
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
Mexican Americans
Females
Males
Serum alphacarotene
(g/dL)
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
4
2
0
Serum alphacarotene
(g/dL)
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum alphacarotene
(g/dL)
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
131
131
Geometric mean
10th
2.76
2.64
1.85
2.48
3.15
3.42
(2.54 2.99)
(2.32 3.01)
(1.69 2.03)
(2.24 2.74)
(2.85 3.47)
(3.05 3.83)
.772
.865
< LOD
.702
.836
1.02
2.37
2.68
1.60
2.10
2.66
3.01
(2.20 2.55)
(2.32 3.10)
(1.46 1.76)
(1.95 2.27)
(2.38 2.96)
(2.61 3.46)
< LOD
.885
< LOD
< LOD
.711
.838
3.18
2.60
2.17
2.92
3.69
3.80
(2.89 3.50)
(2.26 2.99)
(1.98 2.39)
(2.51 3.39)
(3.25 4.17)
(3.33 4.32)
.895
.854
.709
.859
.992
1.18
Males
Females
(.718 .823)
(.766 .966)
50th
90th
Sample
size
2.63
2.59
1.72
2.36
3.01
3.33
(2.40 2.84)
(2.31 2.90)
(1.53 1.91)
(2.06 2.69)
(2.72 3.36)
(2.86 3.86)
9.48
8.34
5.55
8.65
11.8
10.8
(8.58 10.6)
(6.74 10.9)
(4.98 6.67)
(7.55 9.72)
(10.0 13.3)
(9.64 13.1)
7,246
860
1,950
1,684
1,365
1,387
2.23
2.59
1.40
2.00
2.47
3.09
(2.06 2.39)
(2.36 2.91)
(1.29 1.61)
(1.79 2.19)
(2.24 2.76)
(2.55 3.54)
7.74
8.27
4.51
6.91
8.79
9.76
(6.73 9.37)
(5.98 12.0)
(3.69 5.54)
(6.14 7.26)
(7.13 11.5)
(7.73 12.9)
3,544
427
979
736
673
729
(.807 .983)
(.712 .972)
(< LOD .777)
(< LOD .969)
(.764 1.23)
(1.01 1.32)
3.01
2.59
2.08
2.74
3.54
3.50
(2.74 3.32)
(2.14 2.97)
(1.89 2.30)
(2.41 3.31)
(3.07 3.97)
(2.94 4.36)
10.8
8.39
6.43
9.80
13.7
11.6
(9.83 12.3)
(6.99 11.1)
(5.53 7.15)
(8.53 11.9)
(11.7 16.7)
(10.2 15.0)
3,702
433
971
948
692
658
(.780 .985)
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Geometric mean
10th
2.99
2.53
2.06
3.09
3.72
3.76
(2.79 3.21)
(2.21 2.89)
(1.82 2.33)
(2.78 3.42)
(3.31 4.19)
(3.31 4.27)
1.07
.918
.847
1.22
1.44
1.28
2.72
2.46
1.92
2.71
3.49
3.23
(2.50 2.95)
(2.16 2.81)
(1.68 2.19)
(2.30 3.20)
(2.95 4.13)
(2.73 3.83)
3.33
2.60
2.22
3.61
3.99
4.27
(3.07 3.61)
(2.17 3.12)
(1.95 2.53)
(3.16 4.13)
(3.38 4.70)
(3.70 4.93)
Males
Females
50th
90th
Sample
size
(.952 1.21)
(.702 1.14)
(.723 .952)
(1.07 1.33)
(.784 1.77)
(.767 1.60)
2.87
2.47
1.89
2.88
3.57
3.60
(2.61 3.21)
(2.03 3.00)
(1.70 2.22)
(2.56 3.37)
(3.24 4.21)
(3.22 4.31)
7.96
6.79
5.19
7.74
10.5
9.80
(7.58 8.67)
(5.10 9.28)
(4.56 5.91)
(7.18 8.74)
(8.26 14.0)
(8.51 16.0)
1,844
295
646
449
246
208
.997
.904
.785
1.08
1.43
.939
(.890 1.09)
(< LOD 1.25)
(< LOD .874)
(.902 1.24)
(< LOD 1.76)
(< LOD 1.50)
2.57
2.49
1.75
2.47
3.35
3.18
(2.22 3.00)
(1.94 3.20)
(1.50 2.05)
(2.01 3.18)
(2.71 4.08)
(2.62 4.23)
7.27
5.58
5.16
7.32
9.79
8.07
(6.99 7.73)
(4.47 10.7)
(3.85 6.20)
(6.06 8.64)
(7.00 15.0)
(6.41 20.8)
883
145
313
198
122
105
1.20
.923
.937
1.47
1.39
1.52
(1.06 1.30)
(< LOD 1.15)
(.732 1.09)
(1.16 1.62)
(< LOD 1.83)
(< LOD 2.02)
3.26
2.43
2.08
3.45
3.82
4.13
(2.95 3.50)
(1.99 3.17)
(1.81 2.51)
(2.84 4.13)
(3.37 4.47)
(3.36 5.44)
9.08
7.44
5.21
9.06
10.6
9.87
(8.35 9.84)
(5.70 9.89)
(4.55 6.57)
(6.93 13.2)
(7.74 33.5)
(8.65 22.5)
961
150
333
251
124
103
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
132
132
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
1.98
1.97
1.33
1.76
2.60
2.28
(1.74 2.26)
(1.68 2.30)
(1.22 1.46)
(1.47 2.10)
(2.18 3.10)
(2.05 2.54)
< LOD
.782
< LOD
< LOD
< LOD
.727
1.79
2.11
1.28
1.51
2.34
2.04
(1.56 2.06)
(1.80 2.46)
(1.17 1.40)
(1.27 1.80)
(1.84 2.96)
(1.78 2.34)
< LOD
.934
< LOD
< LOD
< LOD
< LOD
2.17
1.84
1.40
2.00
2.85
2.47
(1.91 2.47)
(1.47 2.30)
(1.24 1.57)
(1.63 2.45)
(2.40 3.37)
(2.08 2.94)
< LOD
< LOD
< LOD
< LOD
.763
.778
Males
Females
(.761 1.00)
50th
90th
Sample
size
1.71
1.73
1.17
1.54
2.40
2.09
(1.49 1.99)
(1.47 2.11)
(1.08 1.27)
(1.27 1.85)
(1.86 3.11)
(1.72 2.38)
6.99
4.97
3.23
5.49
9.63
7.35
(5.49 9.49)
(3.84 7.31)
(2.79 4.25)
(3.81 10.9)
(7.77 12.4)
(6.25 9.09)
1,890
240
664
368
335
283
1.55
1.90
1.18
1.26
2.10
1.75
(1.30 1.84)
(1.51 2.50)
(1.10 1.27)
(1.08 1.43)
(1.65 3.05)
(1.48 2.32)
6.12
5.11
2.65
4.23
8.08
6.11
(4.82 7.67)
(4.03 6.81)
(2.27 3.64)
(3.53 10.1)
(6.39 18.0)
(5.37 7.68)
948
128
342
170
156
152
1.91
1.56
1.16
1.83
2.59
2.28
(1.61 2.24)
(1.31 2.06)
(1.01 1.35)
(1.46 2.17)
(1.91 3.59)
(1.69 3.06)
8.09
4.55
3.98
7.48
10.2
8.43
(6.12 10.9)
(3.38 34.6)
(3.08 4.95)
(3.92 14.8)
(7.96 12.8)
(5.57 13.9)
942
112
322
198
179
131
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Geometric mean
10th
2.80
2.78
1.95
2.39
3.12
3.44
(2.60 3.02)
(2.38 3.24)
(1.78 2.13)
(2.16 2.65)
(2.84 3.44)
(3.05 3.88)
.770
.860
< LOD
< LOD
.832
1.05
2.38
2.80
1.62
2.02
2.60
3.00
(2.20 2.56)
(2.34 3.35)
(1.47 1.78)
(1.87 2.18)
(2.33 2.90)
(2.57 3.49)
< LOD
.853
< LOD
< LOD
< LOD
.844
3.28
2.75
2.39
2.83
3.73
3.86
(3.00 3.59)
(2.29 3.31)
(2.19 2.60)
(2.38 3.37)
(3.27 4.26)
(3.34 4.47)
.920
.864
.723
.826
.964
1.24
Males
Females
50th
90th
Sample
size
2.67
2.77
1.85
2.31
2.95
3.34
(2.47 2.89)
(2.37 3.15)
(1.65 2.02)
(1.97 2.65)
(2.63 3.36)
(2.82 3.89)
9.64
8.80
6.10
8.10
11.9
10.7
(8.79 10.7)
(7.05 11.7)
(5.30 7.19)
(7.23 9.64)
(10.1 13.5)
(9.59 12.9)
2,966
231
496
710
683
846
(.761 .959)
2.27
2.80
1.46
1.90
2.42
3.09
(2.08 2.42)
(2.40 2.99)
(1.26 1.72)
(1.65 2.22)
(2.19 2.68)
(2.46 3.54)
7.73
8.52
4.33
6.23
8.71
9.36
(6.50 9.42)
(5.74 23.7)
(3.63 5.81)
(5.68 7.29)
(6.82 10.2)
(7.53 12.8)
1,470
112
254
307
351
446
(.790 1.04)
(< LOD 1.10)
(< LOD .838)
(< LOD .962)
(< LOD 1.23)
(1.05 1.42)
3.10
2.76
2.22
2.69
3.57
3.54
(2.82 3.39)
(1.93 3.26)
(2.06 2.49)
(2.20 3.36)
(3.04 4.01)
(2.85 4.47)
11.2
9.09
6.93
9.45
14.4
12.0
(10.4 12.7)
(7.10 12.4)
(6.25 8.87)
(7.82 11.8)
(12.6 16.7)
(10.4 15.9)
1,496
119
242
403
332
400
(.749 1.02)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
133
133
2.48
2.76
(2.22 2.77)
(2.54 2.99)
< LOD
< LOD
2.39
2.63
(2.10 2.70)
(2.40 2.84)
12.2
14.1
(10.7 14.1)
(12.4 16.5)
7,929
7,246
20012002
2.41
(2.13 2.74)
< LOD
2.14
(1.89 2.48)
12.2
(10.3 14.6)
430
20012002
20052006
2.24
2.64
(2.00 2.51)
(2.32 3.01)
< LOD
< LOD
2.04
2.59
(1.84 2.28)
(2.31 2.90)
8.54
11.5
(6.94 13.3)
(9.30 15.1)
1,014
860
20012002
20052006
1.68
1.85
(1.52 1.86)
(1.69 2.03)
< LOD
< LOD
1.50
1.72
(1.37 1.74)
(1.53 1.91)
7.68
7.91
(6.61 9.52)
(6.65 10.2)
2,206
1,950
20012002
20052006
2.22
2.48
(1.93 2.56)
(2.24 2.74)
< LOD
< LOD
2.11
2.36
(1.82 2.49)
(2.06 2.69)
9.80
11.3
(8.96 12.6)
(10.1 14.7)
1,716
1,684
20012002
20052006
2.98
3.15
(2.60 3.42)
(2.85 3.47)
< LOD
< LOD
2.85
3.01
(2.47 3.28)
(2.72 3.36)
16.0
17.0
(12.8 20.7)
(14.5 21.9)
1,470
1,365
20012002
20052006
3.08
3.42
(2.74 3.46)
(3.05 3.83)
< LOD
.711
3.14
3.33
(2.71 3.61)
(2.86 3.86)
12.7
17.0
(12.0 13.7)
(14.0 19.8)
1,523
1,387
2.22
2.37
(1.98 2.49)
(2.20 2.55)
< LOD
< LOD
2.07
2.23
(1.87 2.44)
(2.06 2.39)
10.3
11.5
(9.30 12.3)
(9.92 13.9)
3,835
3,544
2.76
3.18
(2.47 3.07)
(2.89 3.50)
< LOD
< LOD
2.67
3.01
(2.35 2.97)
(2.74 3.32)
13.3
16.4
(11.8 16.2)
(14.6 18.4)
4,094
3,702
20012002
20052006
2.73
2.99
(2.38 3.14)
(2.79 3.21)
.726
.824
2.63
2.87
(2.38 2.99)
(2.61 3.21)
10.1
10.8
(8.46 14.1)
(10.5 12.5)
1,990
1,844
20012002
20052006
1.77
1.98
(1.50 2.09)
(1.74 2.26)
< LOD
< LOD
1.58
1.71
(1.36 1.91)
(1.49 1.99)
10.1
11.0
(7.64 14.5)
(8.83 14.8)
1,864
1,890
20012002
20052006
2.57
2.80
(2.25 2.95)
(2.60 3.02)
< LOD
< LOD
2.48
2.67
(2.11 2.86)
(2.47 2.89)
12.8
14.4
(11.2 15.5)
(12.8 16.7)
3,450
2,966
Age group
35 years
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
Females
20012002
20052006
Race/ethnicity
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
134
134
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
20
15
10
5
3.5
50th Percentile
3.0
2.5
2.0
1.5
1.0
0.85
0.80
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0.75
0102
5th Percentile
0.90
NHW
(6+y)
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
135
135
136
136
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
11.5
10.8
12.3
10.3
14.2
13.0
9.24
10.4
12.8
16.4
12.1
(10.5 12.7)
(9.72 12.0)
(11.6 13.1)
(9.89 10.8)
(13.3 15.1)
(12.1 14.0)
(8.76 9.75)
(9.63 11.3)
(11.9 13.9)
(15.1 17.7)
(11.5 12.8)
Geometric mean
2.67
2.29
2.20
1.96
2.93
4.14
2.59
2.41
1.94
2.80
2.32
(2.19 3.06)
(2.00 2.54)
(1.90 2.65)
(1.40 2.25)
(2.45 3.23)
(2.67 5.05)
(2.05 2.96)
(1.40 2.81)
(1.36 2.20)
(2.64 3.20)
(1.98 2.67)
2.5th
3.49
3.02
3.06
2.77
3.77
5.15
3.20
3.01
2.69
3.90
3.18
(3.15 3.86)
(2.57 3.36)
(2.80 3.41)
(2.28 3.06)
(3.51 4.05)
(4.11 5.61)
(2.87 3.52)
(2.79 3.23)
(2.15 3.41)
(3.43 4.17)
(2.92 3.42)
5th
11.3
10.5
11.8
10.3
13.2
12.7
8.96
9.97
12.4
15.9
11.6
(10.4 12.4)
(9.31 11.4)
(11.2 12.6)
(9.62 10.9)
(12.0 14.4)
(11.8 13.6)
(8.30 9.66)
(9.14 10.9)
(11.6 13.4)
(14.5 17.8)
(11.1 12.3)
50th
39.2
45.0
56.9
40.8
64.5
37.7
28.3
41.6
63.0
74.6
53.3
(35.1 46.5)
(38.3 53.7)
(50.4 64.9)
(36.8 46.4)
(58.3 73.6)
(29.9 49.2)
(26.3 30.7)
(36.9 53.3)
(53.5 73.8)
(66.3 83.4)
(49.1 59.3)
95th
48.6
57.4
76.2
54.3
84.7
47.6
35.3
59.5
79.2
102
(46.2 59.4)
(51.4 73.5)
(72.3 93.3)
(49.4 66.2)
(75.9 102)
(39.6 100)
(31.3 41.8)
(48.7 85.1)
(73.3 97.9)
(85.9 143)
(68.1 83.3)
97.5th
74.1
1,844
1,891
2,973
3,547
3,707
860
1,954
1,688
1,365
1,387
7,254
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
30
Mexican Americans
10
20
Females
Males
Serum transbetacarotene
(g/dL)
Overall
611
1219
2039
4059
60+
611
4059
60+
10
20
30
NonHispanic Whites
611
1219
2039
4059
60+
611
1219
2039
4059
60+
Males
30
Females
10
20
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum transbetacarotene
(g/dL)
2039
Serum transbetacarotene
(g/dL)
NonHispanic Blacks
1219
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
137
137
Geometric mean
10th
50th
90th
Sample
size
12.1
13.0
9.24
10.4
12.8
16.4
(11.5 12.8)
(12.1 14.0)
(8.76 9.75)
(9.63 11.3)
(11.9 13.9)
(15.1 17.7)
4.26
6.21
4.21
3.85
4.12
5.27
(4.02 4.53)
(5.49 6.89)
(3.86 4.52)
(3.50 4.19)
(3.59 4.55)
(4.47 6.08)
11.6
12.7
8.96
9.97
12.4
15.9
(11.1 12.3)
(11.8 13.6)
(8.30 9.66)
(9.14 10.9)
(11.6 13.4)
(14.5 17.8)
37.1
27.4
20.3
30.4
42.7
51.0
(34.2 40.7)
(25.1 31.7)
(18.9 22.7)
(26.5 35.8)
(39.1 47.5)
(45.9 59.1)
7,254
860
1,954
1,688
1,365
1,387
10.3
13.7
8.46
8.89
10.5
13.3
(9.89 10.8)
(12.6 15.0)
(7.93 9.03)
(8.36 9.46)
(9.38 11.7)
(11.9 14.8)
3.76
6.93
3.82
3.36
3.43
4.47
(3.48 4.02)
(5.62 7.94)
(3.27 4.29)
(3.02 3.80)
(2.20 4.20)
(3.75 5.33)
10.3
13.1
8.26
8.51
10.8
13.0
(9.62 10.9)
(12.1 14.3)
(7.75 8.90)
(7.91 9.14)
(9.45 12.3)
(11.5 14.4)
28.2
27.4
17.8
23.9
31.8
41.5
(26.4 31.4)
(23.5 34.7)
(17.2 18.7)
(22.2 26.7)
(27.9 36.0)
(33.8 51.1)
3,547
427
980
738
673
729
14.2
12.4
10.1
12.2
15.5
19.5
(13.3 15.1)
(11.3 13.5)
(9.48 10.9)
(10.7 13.9)
(14.2 17.0)
(17.4 21.8)
5.00
5.61
4.73
4.39
5.07
6.30
(4.60 5.30)
(4.56 6.75)
(4.26 4.95)
(3.79 5.08)
(4.61 5.33)
(5.12 7.04)
13.2
11.8
9.76
11.4
14.5
19.4
(12.0 14.4)
(10.5 13.6)
(8.95 10.7)
(10.2 12.9)
(12.7 16.2)
(16.5 23.1)
43.9
27.4
24.6
37.0
53.2
62.3
(41.2 48.9)
(24.6 33.5)
(20.9 29.1)
(28.6 50.2)
(44.0 64.4)
(50.5 75.2)
3,707
433
974
950
692
658
Males
Females
Geometric mean
10th
50th
90th
Sample
size
11.5
11.4
9.02
11.5
12.8
14.8
(10.5 12.7)
(10.6 12.4)
(8.39 9.70)
(9.84 13.3)
(11.1 14.8)
(13.2 16.5)
4.48
5.74
4.07
4.45
4.15
5.31
(4.14 4.81)
(4.57 6.28)
(3.59 4.64)
(4.01 4.85)
(3.63 5.03)
(3.02 7.79)
11.3
11.0
9.05
11.3
12.7
14.7
(10.4 12.4)
(9.92 12.0)
(8.35 10.1)
(9.45 13.7)
(11.1 14.7)
(12.7 15.6)
29.7
24.2
18.6
29.9
32.5
43.1
(25.9 35.0)
(21.0 31.1)
(17.3 22.7)
(23.5 37.2)
(27.7 47.1)
(37.9 47.4)
1,844
295
646
449
246
208
10.4
12.0
8.18
10.3
10.9
12.4
(9.29 11.6)
(11.2 12.8)
(7.37 9.07)
(8.45 12.6)
(8.97 13.2)
(10.6 14.6)
4.15
6.15
3.71
4.20
3.82
4.47
(3.63 4.46)
(4.40 7.62)
(3.32 4.25)
(3.00 4.71)
(2.55 4.31)
(2.51 6.70)
10.3
11.5
8.34
9.64
11.3
12.0
(9.20 11.5)
(10.4 12.6)
(6.90 9.63)
(7.83 12.8)
(9.45 13.4)
(9.45 15.9)
25.3
23.1
17.7
26.6
26.3
35.7
(22.6 30.4)
(19.7 34.4)
(15.3 19.6)
(22.0 36.9)
(21.6 35.9)
(19.8 154)
883
145
313
198
122
105
12.9
10.9
10.0
13.0
15.3
17.0
(11.9 14.1)
(9.63 12.3)
(9.35 10.7)
(11.1 15.3)
(12.6 18.5)
(14.7 19.7)
5.08
5.10
4.83
5.15
5.06
5.97
(4.51 5.60)
(3.98 5.96)
(4.12 5.13)
(3.69 6.18)
(3.42 6.68)
(3.10 8.19)
12.5
10.2
10.2
12.6
14.4
15.1
(11.6 13.7)
(8.54 11.9)
(9.47 10.6)
(11.2 15.5)
(12.2 18.3)
(14.3 19.4)
34.4
24.3
20.9
33.8
41.2
44.5
(30.2 39.3)
(19.4 32.8)
(18.0 28.7)
(24.6 45.8)
(29.2 108)
(39.3 50.9)
961
150
333
251
124
103
Males
Females
138
138
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
10.8
11.9
8.46
9.32
12.1
14.7
(9.72 12.0)
(10.6 13.3)
(7.85 9.11)
(8.28 10.5)
(10.3 14.1)
(12.8 16.9)
4.00
6.30
4.09
3.85
3.46
4.60
(3.53 4.34)
(4.86 7.03)
(3.71 4.35)
(3.27 4.22)
(2.33 4.66)
(3.81 5.04)
10.5
11.6
8.13
8.49
12.3
15.3
(9.31 11.4)
(10.9 12.6)
(7.88 8.42)
(7.61 10.2)
(10.3 15.2)
(12.1 18.7)
31.2
23.0
17.9
23.4
40.9
44.8
(26.5 38.3)
(18.3 37.7)
(15.7 21.3)
(19.5 30.8)
(34.3 50.2)
(37.0 51.5)
1,891
240
665
368
335
283
9.49
12.7
8.47
8.00
9.83
12.8
(8.62 10.4)
(11.1 14.5)
(7.78 9.21)
(7.09 9.02)
(8.14 11.9)
(11.3 14.5)
3.48
6.79
4.15
3.39
2.65
3.77
(3.00 3.95)
(5.53 7.49)
(3.18 4.70)
(2.51 3.99)
(1.98 3.42)
(3.46 4.61)
8.92
12.7
8.23
7.16
9.46
12.4
(8.05 9.95)
(10.7 14.9)
(7.85 8.76)
(6.35 7.95)
(7.15 13.1)
(10.7 15.1)
26.5
22.9
17.3
22.0
36.7
35.3
(23.0 32.4)
(18.7 55.1)
(15.8 19.7)
(19.3 26.4)
(26.2 66.7)
(29.1 52.0)
949
128
343
170
156
152
12.1
11.1
8.45
10.6
14.4
16.3
(10.7 13.6)
(9.52 13.0)
(7.74 9.22)
(9.08 12.4)
(12.1 17.1)
(13.5 19.7)
4.49
5.32
4.00
4.27
4.85
4.83
(4.05 4.88)
(3.52 6.63)
(3.50 4.37)
(3.46 5.15)
(2.70 6.42)
(3.86 5.68)
11.5
11.3
8.03
10.8
14.5
17.6
(10.3 13.4)
(9.67 12.5)
(7.59 8.49)
(8.50 12.2)
(11.6 18.4)
(11.6 25.6)
35.5
22.3
18.6
25.4
44.9
46.5
(27.7 46.1)
(16.9 37.0)
(15.5 24.3)
(18.6 46.1)
(39.3 49.0)
(38.7 55.7)
942
112
322
198
179
131
Males
Females
Geometric mean
10th
50th
90th
Sample
size
12.3
13.6
9.58
10.1
12.9
16.3
(11.6 13.1)
(12.4 14.9)
(8.94 10.3)
(9.08 11.1)
(11.8 14.0)
(14.9 17.8)
4.21
6.31
4.36
3.53
4.10
5.29
(3.81 4.60)
(5.42 7.09)
(3.85 4.71)
(3.18 3.94)
(3.54 4.59)
(4.22 6.19)
11.8
13.2
9.14
9.78
12.4
15.9
(11.2 12.6)
(12.1 14.3)
(8.12 10.5)
(8.70 10.6)
(11.4 13.5)
(14.2 18.1)
39.0
27.8
20.9
30.5
43.4
50.9
(34.8 43.4)
(24.9 36.2)
(19.0 26.6)
(25.2 39.1)
(39.4 48.4)
(44.8 64.2)
2,973
231
499
714
683
846
10.4
14.3
8.77
8.65
10.6
13.0
(9.87 11.0)
(12.7 16.1)
(8.14 9.46)
(8.03 9.32)
(9.34 12.0)
(11.5 14.7)
3.71
7.16
3.91
3.13
3.45
4.39
(3.35 4.02)
(4.60 9.03)
(2.92 4.60)
(2.85 3.48)
(2.06 4.26)
(3.31 5.39)
10.5
13.4
8.49
8.30
11.0
12.6
(9.56 11.4)
(12.1 14.7)
(7.53 9.58)
(7.47 9.44)
(9.61 12.4)
(11.0 14.3)
28.6
26.3
17.9
23.8
30.6
41.0
(26.0 33.0)
(23.2 48.8)
(16.6 20.4)
(20.9 26.9)
(26.6 35.9)
(32.8 51.7)
1,472
112
254
309
351
446
14.5
12.9
10.5
11.7
15.6
19.7
(13.5 15.6)
(11.2 14.8)
(9.71 11.5)
(9.95 13.8)
(14.1 17.2)
(17.4 22.3)
4.95
5.61
4.86
4.15
5.00
6.35
(4.33 5.45)
(2.70 7.13)
(4.27 5.37)
(3.18 4.99)
(4.17 5.44)
(5.12 7.18)
13.4
12.6
9.87
10.9
14.2
19.5
(12.2 15.0)
(9.76 15.1)
(8.71 11.3)
(9.35 12.7)
(12.0 17.1)
(16.2 23.5)
46.4
27.7
26.8
36.5
57.1
64.3
(41.5 53.3)
(24.8 40.6)
(21.8 30.1)
(26.6 60.7)
(44.0 69.2)
(50.2 75.5)
1,501
119
245
405
332
400
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
139
139
12.2
12.1
(11.5 12.9)
(11.5 12.8)
3.21
3.18
(2.95 3.46)
(2.92 3.42)
12.0
11.6
(11.3 12.6)
(11.1 12.3)
47.7
53.3
(44.2 52.1)
(49.1 59.3)
7,929
7,254
20012002
13.6
(12.5 14.6)
4.60
(3.79 5.00)
13.6
(12.1 15.2)
45.1
(35.8 56.3)
429
20012002
20052006
13.3
13.0
(12.7 13.9)
(12.1 14.0)
5.44
5.15
(5.00 5.96)
(4.11 5.61)
13.2
12.7
(12.5 13.9)
(11.8 13.6)
32.9
37.7
(30.4 38.8)
(29.9 49.2)
1,012
860
20012002
20052006
9.69
9.24
(9.20 10.2)
(8.76 9.75)
3.34
3.20
(2.97 3.59)
(2.87 3.52)
9.63
8.96
(8.97 10.4)
(8.30 9.66)
28.2
28.3
(25.4 32.5)
(26.3 30.7)
2,206
1,954
20012002
20052006
10.3
10.4
(9.38 11.2)
(9.63 11.3)
2.90
3.01
(2.13 3.20)
(2.79 3.23)
9.81
9.97
(9.10 10.8)
(9.14 10.9)
39.8
41.6
(35.2 42.6)
(36.9 53.3)
1,716
1,688
20012002
20052006
13.3
12.8
(12.1 14.7)
(11.9 13.9)
3.30
2.69
(2.74 3.65)
(2.15 3.41)
13.0
12.4
(12.0 14.2)
(11.6 13.4)
60.0
63.0
(49.9 79.7)
(53.5 73.8)
1,471
1,365
20012002
20052006
16.5
16.4
(14.9 18.3)
(15.1 17.7)
3.51
3.90
(2.88 4.13)
(3.43 4.17)
17.5
15.9
(15.3 19.6)
(14.5 17.8)
61.4
74.6
(56.0 66.1)
(66.3 83.4)
1,524
1,387
20012002
20052006
10.9
10.3
(10.2 11.6)
(9.89 10.8)
3.01
2.77
(2.68 3.25)
(2.28 3.06)
11.0
10.3
(10.3 11.6)
(9.62 10.9)
42.1
40.8
(37.5 45.5)
(36.8 46.4)
3,837
3,547
20012002
20052006
13.6
14.2
(12.7 14.6)
(13.3 15.1)
3.57
3.77
(3.37 3.83)
(3.51 4.05)
13.1
13.2
(12.2 14.2)
(12.0 14.4)
54.1
64.5
(47.6 62.0)
(58.3 73.6)
4,092
3,707
20012002
20052006
12.5
11.5
(11.6 13.4)
(10.5 12.7)
3.56
3.49
(3.12 3.83)
(3.15 3.86)
12.9
11.3
(11.6 13.9)
(10.4 12.4)
38.5
39.2
(34.5 47.5)
(35.1 46.5)
1,990
1,844
20012002
20052006
10.8
10.8
(9.90 11.8)
(9.72 12.0)
2.83
3.02
(2.42 3.22)
(2.57 3.36)
10.7
10.5
(9.93 11.6)
(9.31 11.4)
40.3
45.0
(35.4 45.6)
(38.3 53.7)
1,864
1,891
20012002
20052006
12.5
12.3
(11.5 13.6)
(11.6 13.1)
3.35
3.06
(3.06 3.61)
(2.80 3.41)
12.1
11.8
(11.3 13.0)
(11.2 12.6)
50.8
56.9
(45.8 56.9)
(50.4 64.9)
3,450
2,973
20012002
20052006
Age group
35 years
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
Race/ethnicity
140
140
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
80
60
40
20
16
50th Percentile
14
12
10
8
6
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
2
0102
5th Percentile
NHW
(6+y)
141
141
142
142
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
*
*
*
*
*
*
*
*
*
1.08
(.985 1.17)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
2.5th
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
Geometric mean
5th
< LOD
< LOD
< LOD
< LOD
.759
< LOD
< LOD
< LOD
.730
.903
< LOD
(.708 .816)
50th
2.26
2.81
3.44
2.26
3.88
1.95
1.47
2.51
3.73
4.59
3.20
(1.97 2.59)
(2.37 3.38)
(3.06 3.82)
(1.99 2.60)
(3.60 4.48)
(1.63 2.68)
(1.33 1.81)
(2.08 3.19)
(3.21 4.44)
(3.93 5.32)
(2.87 3.64)
95th
2.80
3.51
4.71
3.09
5.27
2.67
1.87
3.74
4.84
6.53
(2.48 3.46)
(3.17 4.61)
(4.11 5.20)
(2.67 3.91)
(4.71 6.32)
(2.16 4.22)
(1.58 2.39)
(2.88 5.09)
(4.34 5.50)
(5.17 8.65)
(3.93 5.11)
97.5th
4.48
1,707
1,673
2,725
3,204
3,412
779
1,785
1,528
1,254
1,270
6,616
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
No cis-beta-carotene figure for concentrations by age group is presented because the geometric
means were not calculated due to the proportion of results below the limit of detection being
too high for valid results (see Table 2.8.a.1).
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
143
143
Geometric mean
10th
*
*
*
*
*
1.08
Males
Females
50th
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.730
.903
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.704
< LOD
< LOD
< LOD
.726
*
*
*
*
1.04
1.26
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.759
< LOD
< LOD
< LOD
.827
1.15
(.985 1.17)
(.954 1.13)
(1.11 1.41)
(.745 .963)
(.904 1.36)
90th
Sample
size
2.10
1.47
1.12
1.78
2.49
3.09
(1.92 2.39)
(1.28 1.78)
(.995 1.26)
(1.55 2.03)
(2.18 2.86)
(2.62 3.64)
6,616
779
1,785
1,528
1,254
1,270
1.59
1.52
.935
1.37
1.75
2.37
(1.43 1.86)
(1.26 2.33)
(.878 1.02)
(1.23 1.59)
(1.50 2.05)
(1.91 2.99)
3,204
386
886
652
616
664
2.70
1.44
1.35
2.15
3.30
3.69
(2.35 3.10)
(1.21 1.74)
(1.13 1.59)
(1.77 3.04)
(2.72 3.78)
(3.23 4.71)
3,412
393
899
876
638
606
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Geometric mean
10th
*
*
*
*
.880
.964
Males
Females
50th
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.751
.854
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.718
*
*
*
*
1.00
1.09
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.720
< LOD
< LOD
.774
.870
.923
(.780 .992)
(.878 1.06)
(.839 1.19)
(.959 1.24)
90th
Sample
size
1.70
1.34
.975
1.73
1.97
2.48
(1.52 1.91)
(1.09 1.67)
(.899 1.15)
(1.42 2.02)
(1.65 2.75)
(2.05 3.55)
1,707
269
609
402
228
199
1.47
1.34
.900
1.58
1.57
1.61
(1.21 1.71)
(1.06 1.98)
(.833 1.09)
(1.16 2.07)
(1.29 2.19)
(1.08 10.8)
814
131
299
171
114
99
1.95
1.35
1.10
1.88
2.23
2.85
(1.76 2.24)
(1.06 1.72)
(.944 1.46)
(1.57 2.36)
(1.71 6.40)
(2.37 4.06)
893
138
310
231
114
100
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Estimate is subject to greater uncertainty due to small cell size.
144
144
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
*
*
*
*
*
1.04
*
.807
*
*
*
*
*
*
*
*
1.01
1.17
Males
Females
(.906 1.19)
(.695 .937)
(.886 1.16)
(.947 1.44)
50th
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.778
.965
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.738
< LOD
< LOD
< LOD
.784
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.717
< LOD
< LOD
< LOD
.877
1.10
90th
1.87
1.33
1.05
1.41
2.54
2.80
(1.59 2.49)
(1.12 2.11)
(.916 1.20)
(1.24 1.84)
(2.16 3.11)
(2.23 3.45)
1,673
208
580
327
298
260
1.61
1.45
.997
1.27
2.28
1.95
(1.33 1.94)
(1.13 6.80)
(.882 1.17)
(.962 1.84)
(1.51 3.29)
(1.64 3.14)
827
112
290
149
136
140
2.20
1.19
1.08
1.62
2.82
3.16
(1.83 2.77)
(1.03 1.99)
(.914 1.42)
(1.25 2.76)
(2.25 3.43)
(2.59 3.84)
846
96
290
178
162
120
(.765 1.03)
(.720 1.58)
Sample
size
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Estimate is subject to greater uncertainty due to small cell size.
Geometric mean
10th
*
*
*
*
*
1.07
Males
Females
50th
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.720
.892
*
*
*
*
*
*
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
*
*
*
*
1.03
1.26
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.761
< LOD
< LOD
< LOD
.795
1.16
(.967 1.18)
(.941 1.13)
(1.10 1.45)
(.704 .828)
(.718 .966)
(.875 1.38)
90th
Sample
size
2.17
1.46
1.16
1.74
2.50
3.09
(1.92 2.55)
(1.21 2.42)
(.979 1.39)
(1.44 2.15)
(2.11 3.14)
(2.57 3.70)
2,725
212
462
653
634
764
1.59
1.49
.926
1.35
1.69
2.39
(1.42 1.92)
(1.16 5.17)
(.842 1.19)
(1.18 1.59)
(1.46 1.99)
(1.82 3.14)
1,336
102
231
278
324
401
2.79
1.43
1.39
2.14
3.55
3.70
(2.34 3.48)
(1.19 1.98)
(1.12 1.85)
(1.62 3.70)
(2.73 3.96)
(3.16 4.80)
1,389
110
231
375
310
363
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
Estimate is subject to greater uncertainty due to small cell size.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
145
145
*
*
< LOD
< LOD
< LOD
< LOD
2.64
3.20
(2.41 2.87)
(2.87 3.64)
7,929
6,616
20012002
< LOD
< LOD
2.07
(1.88 2.62)
430
20012002
20052006
*
*
< LOD
< LOD
< LOD
< LOD
1.64
1.95
(1.50 1.84)
(1.63 2.68)
1,014
779
20012002
20052006
*
*
< LOD
< LOD
< LOD
< LOD
1.39
1.47
(1.30 1.55)
(1.33 1.81)
2,206
1,785
20012002
20052006
*
*
< LOD
< LOD
< LOD
< LOD
2.05
2.51
(1.82 2.46)
(2.08 3.19)
1,716
1,528
20012002
20052006
*
*
< LOD
< LOD
< LOD
.730
3.30
3.73
(2.77 4.39)
(3.21 4.44)
1,470
1,254
20012002
20052006
1.02
1.08
< LOD
< LOD
.899
.903
(.803 1.02)
(.811 .992)
3.50
4.59
(3.11 3.94)
(3.93 5.32)
1,523
1,270
2.13
2.26
(1.94 2.41)
(1.99 2.60)
3,835
3,204
3.08
3.88
(2.73 3.70)
(3.60 4.48)
4,094
3,412
Age group
35 years
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
(.943 1.11)
(.985 1.17)
20012002
20052006
*
*
< LOD
< LOD
< LOD
< LOD
20012002
20052006
*
*
< LOD
< LOD
< LOD
.759
20012002
20052006
*
*
< LOD
< LOD
< LOD
< LOD
2.06
2.26
(1.85 2.42)
(1.97 2.59)
1,990
1,707
20012002
20052006
*
*
< LOD
< LOD
< LOD
< LOD
2.29
2.81
(1.96 2.69)
(2.37 3.38)
1,864
1,673
20012002
20052006
*
*
< LOD
< LOD
< LOD
< LOD
2.79
3.44
(2.48 3.28)
(3.06 3.82)
3,450
2,725
Females
Race/ethnicity
(.708 .816)
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
* Not calculated. Proportion of results below limit of detection was too high to provide a valid result.
146
146
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
50th Percentile
0.85
0.80
0.75
0.70
0.80
0.75
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0.70
0102
5th Percentile
0.85
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
147
147
148
148
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
13.0
8.34
6.94
7.51
7.89
9.47
7.82
7.95
7.24
7.39
7.70
(11.8 14.3)
(7.88 8.84)
(6.59 7.32)
(7.10 7.94)
(7.53 8.27)
(8.88 10.1)
(7.42 8.23)
(7.52 8.40)
(6.60 7.94)
(6.86 7.97)
(7.34 8.08)
Geometric mean
3.45
2.32
1.66
1.86
1.93
3.41
2.56
2.33
1.48
1.52
1.90
(3.15 3.89)
(2.02 2.51)
(1.47 1.92)
(1.42 2.14)
(1.68 2.10)
(2.68 3.69)
(2.13 2.97)
(1.84 2.53)
(1.14 1.92)
(1.38 1.62)
(1.63 2.06)
2.5th
4.42
2.89
2.26
2.41
2.54
3.90
3.20
2.78
2.16
1.98
2.46
(3.87 4.86)
(2.59 3.11)
(2.07 2.44)
(2.10 2.70)
(2.24 2.69)
(3.32 4.23)
(2.91 3.50)
(2.50 2.97)
(1.80 2.40)
(1.62 2.25)
(2.26 2.63)
5th
12.9
8.23
6.96
7.49
7.74
9.14
7.49
7.81
7.03
7.48
7.62
(11.9 14.2)
(7.80 8.81)
(6.62 7.38)
(7.12 7.88)
(7.28 8.14)
(8.52 9.66)
(7.01 7.99)
(7.31 8.18)
(6.50 7.82)
(7.03 8.13)
(7.24 7.99)
50th
36.2
23.6
20.5
22.8
25.5
24.9
20.3
24.5
24.8
24.2
24.1
(32.4 45.4)
(20.8 27.8)
(19.7 21.9)
(21.5 25.0)
(23.4 28.1)
(23.0 28.7)
(18.8 23.4)
(21.7 28.8)
(21.5 29.2)
(22.7 27.6)
(22.5 26.4)
95th
46.2
29.8
25.5
28.4
32.5
30.4
25.5
31.7
30.3
31.9
(40.7 63.0)
(26.9 35.6)
(23.3 28.2)
(26.4 30.9)
(30.0 37.1)
(27.1 42.3)
(23.6 27.2)
(28.8 38.0)
(27.7 41.1)
(27.8 35.2)
(28.7 33.2)
97.5th
30.5
1,842
1,848
2,960
3,514
3,681
855
1,924
1,679
1,357
1,380
7,195
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
20
Mexican Americans
10
15
Females
Males
Serum betacryptoxanthin
(g/dL)
Overall
611
1219
2039
4059
60+
611
4059
60+
10
15
20
NonHispanic Whites
611
1219
2039
4059
60+
611
1219
2039
4059
60+
Males
20
Females
10
15
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum betacryptoxanthin
(g/dL)
2039
Serum betacryptoxanthin
(g/dL)
NonHispanic Blacks
1219
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
149
149
Geometric mean
10th
50th
90th
Sample
size
7.70
9.47
7.82
7.95
7.24
7.39
(7.34 8.08)
(8.88 10.1)
(7.42 8.23)
(7.52 8.40)
(6.60 7.94)
(6.86 7.97)
3.17
4.47
3.86
3.42
2.76
2.82
(2.95 3.36)
(3.95 5.23)
(3.64 4.01)
(3.06 3.76)
(2.48 3.06)
(2.40 3.01)
7.62
9.14
7.49
7.81
7.03
7.48
(7.24 7.99)
(8.52 9.66)
(7.01 7.99)
(7.31 8.18)
(6.50 7.82)
(7.03 8.13)
18.5
19.5
16.5
18.2
19.3
19.0
(17.5 19.7)
(17.8 21.7)
(15.2 17.8)
(16.7 20.0)
(17.2 21.2)
(17.4 20.7)
7,195
855
1,924
1,679
1,357
1,380
7.51
9.70
7.89
7.86
6.84
7.01
(7.10 7.94)
(8.87 10.6)
(7.36 8.46)
(7.38 8.38)
(6.09 7.69)
(6.37 7.70)
3.13
4.86
3.95
3.49
2.58
2.87
(2.87 3.38)
(3.91 5.70)
(3.55 4.37)
(3.11 3.88)
(2.16 2.91)
(2.36 3.05)
7.49
9.33
7.65
7.74
6.74
7.16
(7.12 7.88)
(8.48 10.2)
(7.02 8.42)
(7.16 8.22)
(6.12 7.68)
(6.44 7.89)
18.0
19.2
16.9
17.9
18.8
17.6
(17.1 19.3)
(17.3 21.7)
(15.0 18.6)
(16.0 19.5)
(16.7 21.9)
(16.7 20.5)
3,514
426
961
735
668
724
7.89
9.23
7.73
8.04
7.63
7.73
(7.53 8.27)
(8.67 9.83)
(7.26 8.23)
(7.52 8.59)
(6.94 8.39)
(7.04 8.48)
3.21
4.21
3.77
3.32
3.08
2.79
(2.99 3.40)
(3.49 4.98)
(3.48 3.96)
(2.93 3.81)
(2.66 3.33)
(2.34 3.03)
7.74
8.82
7.32
7.87
7.35
7.73
(7.28 8.14)
(8.30 9.60)
(6.78 8.01)
(7.27 8.51)
(6.62 8.25)
(7.23 8.79)
19.1
19.7
16.3
19.3
19.7
20.0
(17.9 20.2)
(17.8 23.4)
(14.9 17.8)
(17.0 23.4)
(17.2 20.9)
(18.1 22.9)
3,681
429
963
944
689
656
Males
Females
Geometric mean
10th
50th
90th
Sample
size
13.0
12.4
11.1
13.6
13.3
13.3
(11.8 14.3)
(11.4 13.5)
(10.3 12.1)
(11.7 16.0)
(11.7 15.2)
(11.4 15.6)
5.53
6.01
5.77
5.47
5.34
5.60
(5.21 5.91)
(4.82 6.78)
(5.11 6.34)
(4.92 6.41)
(4.80 5.81)
(2.79 7.53)
12.9
12.3
11.0
13.5
13.6
13.4
(11.9 14.2)
(11.0 14.0)
(10.2 12.1)
(11.7 15.7)
(11.9 15.8)
(11.3 15.8)
29.7
24.8
22.8
31.9
29.8
29.7
(25.9 34.0)
(23.0 27.8)
(19.2 26.1)
(26.5 45.3)
(25.8 35.3)
(24.7 42.9)
1,842
295
646
448
245
208
12.6
12.5
10.7
13.5
12.6
12.0
(11.2 14.1)
(11.3 13.8)
(9.74 11.9)
(11.1 16.4)
(10.5 15.0)
(9.50 15.1)
5.38
6.02
6.00
5.38
5.06
4.24
(4.94 5.92)
(3.82 6.86)
(5.02 6.51)
(4.43 6.71)
(3.45 5.65)
(1.40 7.66)
12.7
12.5
10.5
13.8
13.0
11.4
(11.4 14.4)
(11.2 14.4)
(9.42 11.6)
(11.6 16.0)
(10.4 15.5)
(9.88 15.0)
27.9
24.3
21.7
29.6
30.6
26.9
(24.5 32.7)
(22.2 32.0)
(18.5 26.0)
(22.6 45.6)
(25.0 45.0)
(21.1 37.5)
881
145
313
197
121
105
13.4
12.3
11.6
13.8
14.2
14.5
(12.2 14.6)
(11.3 13.5)
(10.6 12.7)
(11.7 16.2)
(12.2 16.4)
(11.8 18.0)
5.64
5.87
5.49
5.49
5.67
5.79
(5.31 6.10)
(4.89 6.83)
(4.35 6.31)
(4.69 6.54)
(3.59 7.24)
(3.11 7.70)
13.1
11.8
12.1
13.0
13.7
15.4
(12.2 14.2)
(10.9 13.3)
(10.9 13.0)
(11.0 16.0)
(12.5 16.3)
(12.2 17.4)
30.8
26.0
23.4
34.7
29.5
30.1
(26.8 39.3)
(21.9 28.8)
(19.9 30.4)
(29.7 47.2)
(24.9 36.5)
(25.5 59.9)
961
150
333
251
124
103
Males
Females
150
150
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
8.34
11.9
8.69
8.26
7.89
7.38
(7.88 8.84)
(11.1 12.8)
(7.99 9.46)
(7.76 8.78)
(6.95 8.97)
(6.55 8.31)
3.72
6.05
4.54
3.97
2.90
3.16
(3.51 4.02)
(5.13 6.76)
(4.16 4.92)
(3.62 4.26)
(2.54 3.55)
(2.61 3.71)
8.23
11.7
8.47
7.95
7.98
7.31
(7.80 8.81)
(10.6 13.2)
(7.65 9.40)
(7.47 8.71)
(6.88 9.10)
(6.35 8.23)
18.1
22.8
17.4
16.3
18.8
16.8
(17.2 19.3)
(19.7 25.0)
(15.7 19.0)
(15.0 18.9)
(17.2 22.3)
(15.5 21.8)
1,848
237
637
363
332
279
8.23
12.5
8.80
8.26
7.49
6.73
(7.64 8.87)
(11.2 14.0)
(8.01 9.67)
(7.73 8.83)
(6.22 9.03)
(6.08 7.45)
3.58
6.69
4.43
4.00
2.63
2.92
(3.20 3.89)
(4.92 7.69)
(3.92 4.96)
(3.65 4.31)
(2.42 2.81)
(2.43 3.29)
8.03
12.6
8.50
7.41
7.64
6.06
(7.38 8.90)
(10.6 14.7)
(7.75 9.40)
(7.04 7.98)
(6.42 9.09)
(5.09 7.20)
19.0
23.9
18.2
18.2
19.0
17.0
(17.7 20.9)
(21.5 25.6)
(15.8 20.7)
(15.3 21.6)
(17.1 24.6)
(15.6 17.8)
922
127
325
168
153
149
8.44
11.2
8.59
8.25
8.24
7.89
(8.04 8.86)
(9.74 13.0)
(7.79 9.46)
(7.69 8.86)
(7.42 9.14)
(6.67 9.33)
3.87
5.33
4.66
3.73
3.64
3.67
(3.56 4.40)
(4.18 6.55)
(4.22 5.04)
(3.50 4.18)
(2.54 4.52)
(2.29 4.00)
8.39
10.8
8.46
8.14
8.22
7.96
(8.01 8.86)
(9.90 12.2)
(7.40 9.63)
(7.80 8.94)
(6.90 9.23)
(6.64 9.20)
17.3
19.6
16.6
15.6
18.5
16.5
(16.4 18.5)
(17.8 30.0)
(14.9 18.0)
(13.7 20.1)
(16.3 21.5)
(14.7 26.2)
926
110
312
195
179
130
Males
Females
Geometric mean
10th
50th
90th
Sample
size
6.94
8.29
7.12
6.90
6.63
7.05
(6.59 7.32)
(7.73 8.89)
(6.60 7.68)
(6.60 7.21)
(5.99 7.33)
(6.51 7.64)
2.93
4.21
3.72
3.01
2.63
2.75
(2.72 3.14)
(3.43 4.88)
(3.31 3.93)
(2.73 3.40)
(2.35 2.88)
(2.28 2.96)
6.96
8.12
6.82
6.93
6.61
7.26
(6.62 7.38)
(7.60 8.69)
(6.07 7.64)
(6.69 7.24)
(6.11 7.28)
(6.66 7.79)
16.3
15.7
14.2
15.1
17.2
17.7
(15.3 17.4)
(14.5 17.9)
(13.1 16.1)
(13.3 16.5)
(14.6 20.0)
(16.8 19.6)
2,960
230
497
711
679
843
6.83
8.45
7.38
6.94
6.39
6.66
(6.42 7.28)
(7.44 9.60)
(6.60 8.26)
(6.51 7.40)
(5.62 7.26)
(6.02 7.37)
2.92
4.43
3.87
3.15
2.42
2.78
(2.50 3.23)
(3.50 5.65)
(3.20 4.40)
(2.80 3.53)
(1.99 2.82)
(2.23 3.04)
6.90
7.99
7.10
7.06
6.31
6.94
(6.58 7.29)
(7.29 9.15)
(6.14 8.39)
(6.75 7.53)
(5.75 6.96)
(5.82 7.73)
15.9
15.9
14.5
14.0
17.6
17.0
(14.6 17.5)
(14.0 21.0)
(12.6 17.5)
(12.1 16.7)
(14.6 21.6)
(15.2 18.8)
1,468
112
253
309
350
444
7.05
8.11
6.84
6.86
6.87
7.39
(6.69 7.43)
(7.34 8.95)
(6.25 7.48)
(6.45 7.28)
(6.18 7.64)
(6.69 8.17)
2.94
3.85
3.57
2.92
2.84
2.73
(2.70 3.20)
(3.04 4.45)
(2.93 3.86)
(2.53 3.38)
(2.52 3.24)
(2.26 2.94)
7.04
8.14
6.57
6.73
6.84
7.50
(6.59 7.55)
(7.69 8.60)
(5.73 7.38)
(6.29 7.41)
(6.09 7.85)
(6.74 8.69)
16.6
15.0
14.0
15.7
16.5
19.5
(15.4 18.1)
(13.3 22.0)
(12.8 16.4)
(13.5 18.2)
(14.4 19.9)
(17.0 21.2)
1,492
118
244
402
329
399
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
151
151
7.46
7.70
(7.06 7.87)
(7.34 8.08)
2.45
2.46
(2.20 2.68)
(2.26 2.63)
7.40
7.62
(7.00 7.82)
(7.24 7.99)
23.0
24.1
(20.9 25.5)
(22.5 26.4)
7,890
7,195
20012002
9.43
(8.40 10.6)
3.30
(1.88 3.96)
9.09
(7.81 10.4)
30.7
(25.3 43.1)
427
20012002
20052006
9.40
9.47
(8.71 10.2)
(8.88 10.1)
3.92
3.90
(3.28 4.22)
(3.32 4.23)
9.05
9.14
(8.29 10.2)
(8.52 9.66)
26.1
24.9
(21.9 31.6)
(23.0 28.7)
1,006
855
20012002
20052006
7.63
7.82
(7.20 8.08)
(7.42 8.23)
3.05
3.20
(2.58 3.31)
(2.91 3.50)
7.45
7.49
(7.00 7.99)
(7.01 7.99)
19.8
20.3
(18.5 22.3)
(18.8 23.4)
2,199
1,924
20012002
20052006
7.11
7.95
(6.57 7.69)
(7.52 8.40)
2.40
2.78
(2.04 2.73)
(2.50 2.97)
6.83
7.81
(6.25 7.50)
(7.31 8.18)
22.9
24.5
(20.0 26.6)
(21.7 28.8)
1,707
1,679
20012002
20052006
7.28
7.24
(6.75 7.86)
(6.60 7.94)
2.39
2.16
(2.02 2.71)
(1.80 2.40)
7.16
7.03
(6.66 7.77)
(6.50 7.82)
23.2
24.8
(20.4 26.1)
(21.5 29.2)
1,459
1,357
20012002
20052006
7.44
7.39
(6.84 8.09)
(6.86 7.97)
1.94
1.98
(1.71 2.22)
(1.62 2.25)
7.64
7.48
(7.06 8.28)
(7.03 8.13)
23.5
24.2
(20.9 27.8)
(22.7 27.6)
1,519
1,380
20012002
20052006
7.28
7.51
(6.89 7.69)
(7.10 7.94)
2.41
2.41
(2.10 2.66)
(2.10 2.70)
7.32
7.49
(6.82 7.81)
(7.12 7.88)
22.3
22.8
(20.4 25.0)
(21.5 25.0)
3,815
3,514
20012002
20052006
7.63
7.89
(7.20 8.08)
(7.53 8.27)
2.48
2.54
(2.29 2.75)
(2.24 2.69)
7.45
7.74
(7.05 7.84)
(7.28 8.14)
23.8
25.5
(21.1 26.2)
(23.4 28.1)
4,075
3,681
20012002
20052006
12.1
13.0
(11.2 13.2)
(11.8 14.3)
4.14
4.42
(3.71 4.53)
(3.87 4.86)
12.1
12.9
(10.9 13.5)
(11.9 14.2)
34.5
36.2
(32.1 38.5)
(32.4 45.4)
1,988
1,842
20012002
20052006
8.03
8.34
(7.38 8.74)
(7.88 8.84)
2.99
2.89
(2.66 3.27)
(2.59 3.11)
7.92
8.23
(7.32 8.55)
(7.80 8.81)
23.0
23.6
(19.9 27.7)
(20.8 27.8)
1,859
1,848
20012002
20052006
6.80
6.94
(6.43 7.19)
(6.59 7.32)
2.36
2.26
(2.05 2.53)
(2.07 2.44)
6.71
6.96
(6.29 7.16)
(6.62 7.38)
19.6
20.5
(18.2 22.2)
(19.7 21.9)
3,422
2,960
20012002
20052006
Age group
35 years
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
Race/ethnicity
152
152
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
50
95th Percentile
40
1
30
1
1
20
1
1
10
16
50th Percentile
14
1
12
10
1
8
1
6
5
1
1
1
0506
0102
0506
0102
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
1
0102
5th Percentile
NHW
(6+y)
153
153
154
154
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
15.1
15.3
13.2
13.6
14.0
13.1
10.7
13.6
14.5
15.5
13.8
(14.5 15.8)
(14.8 15.8)
(12.8 13.6)
(13.1 14.0)
(13.5 14.4)
(12.6 13.7)
(10.3 11.1)
(13.1 14.1)
(13.8 15.2)
(14.9 16.2)
(13.4 14.2)
Geometric mean
6.36
5.88
4.74
4.92
4.98
5.74
4.91
4.94
4.62
5.27
4.95
(5.62 6.79)
(5.20 6.37)
(4.46 4.96)
(4.48 5.30)
(4.62 5.26)
(4.13 6.47)
(4.39 5.18)
(4.24 5.46)
(4.02 5.31)
(4.72 5.83)
(4.69 5.19)
2.5th
7.41
7.03
5.70
5.93
5.89
6.70
5.67
5.91
5.82
6.44
5.90
(6.79 7.83)
(6.33 7.71)
(5.33 5.88)
(5.42 6.35)
(5.69 6.13)
(5.50 7.67)
(5.21 5.91)
(5.19 6.41)
(5.28 6.13)
(6.02 6.69)
(5.68 6.18)
5th
15.0
15.4
12.9
13.5
13.8
13.3
10.6
13.6
14.5
15.7
13.7
(14.4 15.6)
(15.0 15.8)
(12.5 13.4)
(13.0 14.1)
(13.3 14.4)
(12.8 13.9)
(10.0 11.1)
(12.9 14.4)
(13.7 15.2)
(15.0 16.5)
(13.2 14.1)
50th
31.3
31.5
30.9
30.7
32.8
24.5
20.0
29.3
35.7
35.9
31.3
(29.2 34.1)
(29.4 35.1)
(29.1 32.8)
(28.7 31.4)
(31.0 35.7)
(23.5 27.4)
(19.1 21.1)
(27.7 32.1)
(33.3 37.8)
(32.8 40.3)
(30.3 33.2)
95th
35.5
38.0
37.5
35.7
39.9
29.0
22.7
35.2
40.8
42.5
(33.2 40.8)
(34.8 41.7)
(34.4 39.9)
(33.3 39.0)
(38.4 41.5)
(27.3 30.2)
(21.4 25.1)
(31.7 40.0)
(38.5 46.1)
(39.7 51.2)
(37.0 40.0)
97.5th
38.5
1,844
1,891
2,973
3,547
3,707
860
1,954
1,688
1,365
1,387
7,254
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
20
30
Mexican Americans
10
Females
Males
Serum lutein/zeaxanthin
(g/dL)
Overall
611
1219
2039
4059
60+
611
4059
60+
20
30
NonHispanic Whites
10
611
1219
2039
4059
60+
611
1219
2039
4059
60+
Males
20
30
Females
10
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum lutein/zeaxanthin
(g/dL)
2039
Serum lutein/zeaxanthin
(g/dL)
NonHispanic Blacks
1219
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
155
155
Geometric mean
10th
50th
90th
Sample
size
13.8
13.1
10.7
13.6
14.5
15.5
(13.4 14.2)
(12.6 13.7)
(10.3 11.1)
(13.1 14.1)
(13.8 15.2)
(14.9 16.2)
7.24
7.93
6.50
7.40
7.23
7.89
(6.91 7.49)
(6.84 8.54)
(6.19 6.74)
(6.64 7.83)
(6.70 7.58)
(7.52 8.13)
13.7
13.3
10.6
13.6
14.5
15.7
(13.2 14.1)
(12.8 13.9)
(10.0 11.1)
(12.9 14.4)
(13.7 15.2)
(15.0 16.5)
26.5
20.7
17.6
25.1
29.4
29.0
(25.7 27.3)
(20.1 22.0)
(16.9 18.4)
(23.4 27.1)
(27.5 31.0)
(27.3 31.9)
7,254
860
1,954
1,688
1,365
1,387
13.6
13.4
10.5
13.4
14.2
15.5
(13.1 14.0)
(12.7 14.1)
(10.1 10.9)
(12.8 14.0)
(13.4 15.0)
(14.7 16.4)
7.22
8.08
6.49
7.26
7.22
7.94
(6.78 7.61)
(7.62 8.69)
(6.06 6.86)
(6.51 7.96)
(5.99 7.90)
(7.26 8.26)
13.5
13.6
10.3
13.4
14.1
15.9
(13.0 14.1)
(12.5 14.2)
(9.91 10.9)
(12.8 14.2)
(13.1 15.1)
(15.2 17.0)
25.6
20.5
17.3
23.8
27.6
27.8
(24.5 26.2)
(19.0 22.5)
(16.7 18.3)
(22.4 26.0)
(26.6 31.0)
(26.2 31.2)
3,547
427
980
738
673
729
14.0
12.9
10.9
13.8
14.7
15.6
(13.5 14.4)
(12.1 13.7)
(10.3 11.4)
(13.2 14.5)
(13.9 15.6)
(14.8 16.4)
7.27
7.63
6.52
7.42
7.17
7.80
(6.77 7.56)
(5.98 8.50)
(5.98 6.93)
(6.59 7.80)
(6.76 7.56)
(7.40 8.17)
13.8
13.1
10.8
13.8
15.0
15.6
(13.3 14.4)
(12.6 13.7)
(10.1 11.5)
(12.9 14.8)
(13.8 16.2)
(14.1 16.7)
27.5
21.4
18.0
25.7
29.6
29.8
(26.7 28.5)
(19.9 23.6)
(16.9 19.1)
(23.9 28.0)
(28.9 32.2)
(28.0 32.8)
3,707
433
974
950
692
658
Males
Females
Geometric mean
10th
50th
90th
Sample
size
15.1
13.2
12.1
15.4
17.2
18.6
(14.5 15.8)
(12.4 14.0)
(11.5 12.7)
(14.3 16.6)
(16.0 18.5)
(16.7 20.7)
8.60
8.43
7.64
8.96
9.78
9.96
(8.07 9.17)
(6.89 9.35)
(7.22 8.01)
(8.09 9.65)
(7.36 11.0)
(7.59 12.0)
15.0
13.3
12.3
15.4
17.2
18.7
(14.4 15.6)
(12.2 14.1)
(11.7 12.9)
(14.2 17.3)
(16.2 18.5)
(16.9 20.3)
26.8
21.1
18.9
26.2
30.4
32.2
(25.2 28.6)
(19.3 23.5)
(18.0 20.0)
(23.4 30.5)
(27.3 36.3)
(30.1 34.4)
1,844
295
646
449
246
208
15.4
13.0
11.7
16.0
17.7
19.1
(14.5 16.3)
(12.1 13.9)
(11.0 12.5)
(14.6 17.5)
(15.7 19.9)
(16.0 22.7)
8.81
8.75
7.62
9.47
8.69
10.7
(8.00 9.51)
(6.33 9.71)
(6.85 8.20)
(8.02 10.1)
(5.55 11.6)
(6.38 12.2)
15.1
13.1
12.0
15.8
17.6
18.5
(14.4 16.0)
(12.1 13.9)
(10.9 12.9)
(14.9 17.4)
(16.1 19.9)
(14.5 25.4)
28.1
19.6
18.2
28.5
31.1
34.1
(25.6 31.1)
(17.5 22.0)
(17.4 19.2)
(24.2 33.1)
(27.0 52.1)
(29.9 45.4)
883
145
313
198
122
105
14.9
13.4
12.5
14.7
16.7
18.2
(14.2 15.6)
(12.5 14.4)
(11.9 13.1)
(13.7 15.9)
(15.6 18.0)
(16.1 20.7)
8.46
7.94
7.61
8.18
10.1
9.82
(7.68 9.34)
(6.66 8.97)
(7.08 8.14)
(7.42 9.74)
(7.40 10.9)
(7.45 11.7)
14.7
13.6
12.8
14.7
16.6
18.8
(14.1 15.5)
(11.9 14.4)
(12.3 13.1)
(13.1 16.9)
(14.5 18.4)
(16.2 21.7)
24.4
23.4
19.7
23.1
28.6
30.6
(23.3 27.0)
(19.8 27.1)
(18.3 20.8)
(22.2 27.0)
(23.7 44.2)
(28.3 33.6)
961
150
333
251
124
103
Males
Females
156
156
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
15.3
15.8
12.9
14.5
16.4
17.4
(14.8 15.8)
(15.3 16.4)
(12.3 13.5)
(13.7 15.3)
(15.5 17.4)
(16.0 19.1)
8.61
10.5
7.94
8.29
8.77
8.99
(8.21 9.04)
(9.30 11.0)
(7.37 8.38)
(6.74 9.45)
(7.81 9.51)
(8.24 10.1)
15.4
16.2
13.0
14.4
17.0
17.7
(15.0 15.8)
(15.6 16.8)
(12.1 13.7)
(13.5 15.4)
(15.8 18.2)
(16.0 19.1)
26.6
23.9
20.9
25.3
28.6
31.5
(25.2 28.4)
(22.5 27.4)
(19.5 22.1)
(24.0 28.3)
(26.6 30.2)
(27.1 36.5)
1,891
240
665
368
335
283
15.4
15.9
13.1
14.6
16.9
17.1
(14.9 15.9)
(14.9 16.9)
(12.4 13.8)
(13.8 15.5)
(15.8 18.1)
(16.2 18.1)
8.69
11.1
8.08
8.48
9.21
8.83
(8.26 9.42)
(10.3 11.9)
(7.27 8.68)
(6.56 9.65)
(7.66 9.97)
(7.79 9.64)
15.6
15.9
13.3
14.2
18.2
17.9
(14.9 16.3)
(15.0 17.2)
(12.2 14.6)
(13.1 15.7)
(15.6 19.3)
(17.2 18.8)
26.6
23.1
20.8
26.3
30.6
29.0
(25.6 28.4)
(21.9 26.9)
(19.6 21.9)
(23.2 29.1)
(27.5 36.0)
(25.9 34.0)
949
128
343
170
156
152
15.2
15.8
12.7
14.4
16.0
17.7
(14.5 15.8)
(15.1 16.5)
(11.9 13.6)
(13.4 15.5)
(15.0 17.1)
(15.2 20.5)
8.51
9.57
7.70
8.03
8.72
9.08
(7.69 9.12)
(7.86 10.7)
(6.62 8.68)
(5.21 9.63)
(7.23 9.34)
(7.95 10.6)
15.3
16.5
12.7
14.7
16.6
17.3
(14.8 15.9)
(14.8 17.1)
(11.4 13.6)
(13.6 15.4)
(15.6 17.6)
(15.1 20.2)
26.4
24.0
21.1
24.6
26.9
33.2
(24.6 29.1)
(22.3 28.9)
(19.1 23.5)
(23.2 28.5)
(24.6 29.9)
(26.3 57.9)
942
112
322
198
179
131
Males
Females
Geometric mean
10th
50th
90th
Sample
size
13.2
12.5
9.88
12.7
13.8
15.0
(12.8 13.6)
(11.8 13.3)
(9.46 10.3)
(12.2 13.1)
(13.0 14.6)
(14.4 15.7)
6.80
7.68
6.16
6.56
6.87
7.59
(6.48 7.16)
(6.04 8.34)
(5.75 6.48)
(5.93 7.39)
(6.26 7.25)
(7.25 7.97)
12.9
12.7
9.80
12.4
13.7
15.2
(12.5 13.4)
(12.2 13.6)
(9.34 10.3)
(11.7 13.2)
(12.6 15.1)
(14.2 15.8)
25.8
19.8
16.2
23.6
27.9
28.5
(25.1 26.9)
(18.3 23.1)
(15.0 17.1)
(22.1 26.9)
(26.7 30.2)
(26.4 31.4)
2,973
231
499
714
683
846
13.0
12.9
9.75
12.4
13.6
15.0
(12.5 13.4)
(11.8 14.2)
(9.24 10.3)
(11.9 12.9)
(12.8 14.4)
(14.2 15.9)
6.87
7.95
6.23
6.55
6.96
7.59
(6.45 7.22)
(5.77 8.67)
(5.55 6.75)
(5.75 7.69)
(5.83 7.71)
(7.11 8.05)
12.8
13.0
9.71
12.3
13.4
15.4
(12.2 13.5)
(12.2 14.1)
(9.33 10.0)
(11.7 13.0)
(12.3 14.9)
(14.4 16.5)
24.4
18.9
15.6
22.7
26.6
26.6
(23.5 25.7)
(17.1 31.9)
(14.3 16.9)
(21.8 24.8)
(24.5 29.9)
(25.5 30.6)
1,472
112
254
309
351
446
13.4
12.1
10.0
12.9
14.0
15.1
(12.9 13.8)
(11.1 13.2)
(9.21 10.9)
(12.2 13.6)
(13.0 15.0)
(14.3 15.9)
6.75
6.73
6.08
6.60
6.78
7.58
(6.20 7.26)
(5.07 8.32)
(5.23 6.57)
(5.82 7.42)
(5.98 7.28)
(6.96 8.05)
13.0
12.4
9.90
12.6
14.0
14.7
(12.4 13.7)
(11.1 13.2)
(9.18 11.1)
(11.2 14.4)
(12.5 15.7)
(13.6 16.2)
27.4
19.9
16.5
25.0
29.2
29.2
(26.0 28.1)
(18.2 28.1)
(15.3 18.1)
(22.3 28.5)
(27.5 30.7)
(27.6 32.6)
1,501
119
245
405
332
400
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
157
157
13.1
13.8
(12.5 13.6)
(13.4 14.2)
5.77
5.90
(5.53 6.00)
(5.68 6.18)
12.9
13.7
(12.2 13.5)
(13.2 14.1)
30.4
31.3
(28.6 32.2)
(30.3 33.2)
7,923
7,254
20012002
12.5
(11.8 13.2)
6.38
(5.82 7.04)
12.5
(12.0 13.1)
24.6
(22.2 31.5)
430
20012002
20052006
12.5
13.1
(11.9 13.2)
(12.6 13.7)
6.61
6.70
(5.88 7.06)
(5.50 7.67)
12.3
13.3
(11.6 13.1)
(12.8 13.9)
24.8
24.5
(22.4 26.0)
(23.5 27.4)
1,014
860
20012002
20052006
10.4
10.7
(9.91 11.0)
(10.3 11.1)
4.99
5.67
(4.64 5.54)
(5.21 5.91)
10.4
10.6
(9.80 11.0)
(10.0 11.1)
20.9
20.0
(19.4 23.2)
(19.1 21.1)
2,205
1,954
20012002
20052006
12.1
13.6
(11.5 12.9)
(13.1 14.1)
5.47
5.91
(5.16 5.73)
(5.19 6.41)
12.0
13.6
(11.2 12.7)
(12.9 14.4)
27.1
29.3
(25.7 30.7)
(27.7 32.1)
1,714
1,688
20012002
20052006
14.4
14.5
(13.6 15.2)
(13.8 15.2)
6.47
5.82
(5.69 7.04)
(5.28 6.13)
14.1
14.5
(13.5 14.9)
(13.7 15.2)
32.6
35.7
(31.0 35.5)
(33.3 37.8)
1,468
1,365
20012002
20052006
15.2
15.5
(14.3 16.2)
(14.9 16.2)
6.14
6.44
(5.54 6.68)
(6.02 6.69)
15.3
15.7
(14.3 16.6)
(15.0 16.5)
35.1
35.9
(33.3 41.0)
(32.8 40.3)
1,522
1,387
20012002
20052006
13.0
13.6
(12.5 13.6)
(13.1 14.0)
5.67
5.93
(5.35 6.01)
(5.42 6.35)
13.0
13.5
(12.4 13.6)
(13.0 14.1)
29.8
30.7
(28.3 31.7)
(28.7 31.4)
3,832
3,547
20012002
20052006
13.1
14.0
(12.5 13.7)
(13.5 14.4)
5.87
5.89
(5.59 6.03)
(5.69 6.13)
12.7
13.8
(12.1 13.5)
(13.3 14.4)
31.4
32.8
(28.8 33.0)
(31.0 35.7)
4,091
3,707
20012002
20052006
13.7
15.1
(13.3 14.2)
(14.5 15.8)
6.58
7.41
(6.15 6.84)
(6.79 7.83)
13.6
15.0
(13.2 14.1)
(14.4 15.6)
28.5
31.3
(26.8 30.7)
(29.2 34.1)
1,988
1,844
20012002
20052006
14.2
15.3
(13.1 15.5)
(14.8 15.8)
6.80
7.03
(6.20 7.20)
(6.33 7.71)
14.1
15.4
(12.8 15.5)
(15.0 15.8)
30.7
31.5
(28.5 34.6)
(29.4 35.1)
1,864
1,891
20012002
20052006
12.6
13.2
(12.0 13.2)
(12.8 13.6)
5.60
5.70
(5.14 5.90)
(5.33 5.88)
12.4
12.9
(11.7 13.1)
(12.5 13.4)
28.8
30.9
(27.2 31.8)
(29.1 32.8)
3,447
2,973
20012002
20052006
Age group
35 years
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
Race/ethnicity
158
158
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
40
35
95th Percentile
30
25
i
i
20
15
16
i
i
i
50th Percentile
14
i
i
i
i
i
12
10
8
8
i
i
i
i
i
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
0102
0506
4
0102
5th Percentile
NHW
(6+y)
159
159
160
160
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
19.5
22.0
21.3
21.8
20.6
21.7
21.9
23.9
21.6
16.4
21.2
(19.1 20.0)
(20.9 23.2)
(20.8 21.9)
(21.0 22.6)
(20.0 21.2)
(20.5 22.9)
(21.1 22.6)
(23.3 24.4)
(20.4 22.8)
(15.4 17.4)
(20.7 21.7)
Geometric mean
7.04
6.29
5.46
5.79
5.47
7.67
8.42
8.24
5.13
3.75
5.64
(6.09 7.33)
(5.46 6.99)
(4.83 6.26)
(4.54 6.70)
(4.93 6.39)
(5.27 9.29)
(7.31 8.78)
(7.38 8.96)
(3.76 6.34)
(2.69 4.36)
(4.99 6.25)
2.5th
8.80
8.11
7.69
7.85
7.76
9.48
9.91
10.7
7.69
5.19
7.81
(7.83 9.29)
(7.39 8.77)
(7.04 8.47)
(6.99 8.89)
(7.09 8.40)
(7.38 10.9)
(8.98 11.0)
(8.97 11.4)
(6.02 8.98)
(4.32 5.97)
(7.33 8.40)
5th
20.2
23.5
23.0
23.4
22.2
22.5
22.3
25.1
23.2
17.8
22.7
(19.6 20.9)
(22.6 24.7)
(22.4 23.5)
(22.6 24.3)
(21.5 22.6)
(21.1 23.7)
(21.8 22.9)
(24.3 25.6)
(22.1 24.4)
(16.8 19.0)
(22.2 23.2)
50th
38.0
47.0
43.8
44.7
42.3
42.8
42.6
46.1
44.6
38.8
43.6
(36.4 40.2)
(44.7 49.5)
(42.4 45.2)
(43.7 47.0)
(41.2 43.9)
(40.0 46.0)
(40.2 45.1)
(44.1 47.2)
(42.5 47.1)
(37.3 40.7)
(42.4 44.9)
95th
42.5
53.5
48.5
52.1
46.3
46.1
46.8
51.6
50.0
44.4
(39.8 49.9)
(51.0 57.3)
(47.3 50.6)
(49.0 55.7)
(45.1 48.8)
(44.0 54.8)
(44.4 52.7)
(48.9 53.5)
(47.2 55.9)
(40.7 46.5)
(47.5 49.8)
97.5th
48.4
1,844
1,891
2,973
3,547
3,707
860
1,954
1,688
1,365
1,387
7,254
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
Mexican Americans
10
20
Females
Males
Serum translycopene
(g/dL)
30
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
20
10
0
Serum translycopene
(g/dL)
30
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
10
20
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum translycopene
(g/dL)
30
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
161
161
Geometric mean
10th
50th
90th
Sample
size
21.2
21.7
21.9
23.9
21.6
16.4
(20.7 21.7)
(20.5 22.9)
(21.1 22.6)
(23.3 24.4)
(20.4 22.8)
(15.4 17.4)
10.7
11.6
12.9
13.4
11.0
7.14
(10.1 11.3)
(10.5 12.9)
(12.2 13.6)
(11.8 14.8)
(9.50 11.9)
(6.48 7.69)
22.7
22.5
22.3
25.1
23.2
17.8
(22.2 23.2)
(21.1 23.7)
(21.8 22.9)
(24.3 25.6)
(22.1 24.4)
(16.8 19.0)
38.9
38.3
37.2
40.2
39.9
33.7
(37.7 39.8)
(36.3 40.3)
(35.8 39.1)
(39.5 41.2)
(38.4 41.8)
(32.3 36.1)
7,254
860
1,954
1,688
1,365
1,387
21.8
22.6
22.2
25.1
21.9
16.3
(21.0 22.6)
(21.4 23.9)
(21.4 23.0)
(24.0 26.2)
(20.1 23.9)
(15.1 17.6)
11.2
12.8
13.4
14.6
10.9
7.44
(10.3 11.8)
(11.0 14.4)
(11.5 14.2)
(11.9 15.8)
(8.58 12.4)
(6.33 7.78)
23.4
23.1
22.7
26.2
23.9
17.8
(22.6 24.3)
(21.8 24.3)
(22.0 23.6)
(24.9 27.4)
(22.3 25.6)
(16.4 19.1)
39.6
38.6
37.2
41.4
40.6
33.5
(38.1 41.0)
(36.9 40.8)
(36.3 38.7)
(40.0 43.7)
(37.3 43.9)
(31.3 36.8)
3,547
427
980
738
673
729
20.6
20.8
21.5
22.7
21.3
16.4
(20.0 21.2)
(18.9 22.8)
(20.1 23.0)
(22.1 23.3)
(20.1 22.5)
(15.3 17.6)
10.3
10.4
12.8
12.9
11.0
6.89
(9.56 11.1)
(8.68 12.8)
(10.7 13.7)
(11.1 14.2)
(9.50 11.9)
(6.29 7.73)
22.2
21.7
21.9
23.7
22.4
17.9
(21.5 22.6)
(20.3 23.5)
(21.0 23.2)
(23.0 24.6)
(21.0 24.3)
(16.6 19.3)
38.2
37.3
37.1
39.0
39.3
34.2
(36.7 39.5)
(35.2 41.9)
(34.6 40.6)
(35.9 41.3)
(38.6 40.8)
(31.5 38.3)
3,707
433
974
950
692
658
Males
Females
Geometric mean
10th
50th
90th
Sample
size
19.5
19.6
20.0
20.9
18.4
15.5
(19.1 20.0)
(18.5 20.8)
(19.2 20.9)
(19.7 22.1)
(17.3 19.5)
(14.0 17.1)
10.7
11.0
12.0
11.6
10.0
7.71
(10.1 11.2)
(9.47 13.0)
(10.1 12.8)
(9.65 13.5)
(9.04 11.0)
(5.24 8.87)
20.2
20.1
20.9
22.0
18.8
16.1
(19.6 20.9)
(19.1 21.2)
(19.8 22.1)
(21.0 23.3)
(18.2 19.4)
(14.7 17.7)
33.7
32.4
33.5
34.7
32.8
28.6
(32.8 34.4)
(31.2 34.0)
(32.3 35.2)
(33.4 38.1)
(30.6 37.0)
(26.1 33.2)
1,844
295
646
449
246
208
20.1
19.0
20.6
21.9
18.6
15.5
(19.4 20.8)
(17.8 20.2)
(19.2 22.1)
(20.0 23.9)
(17.1 20.2)
(12.9 18.6)
11.0
10.9
12.3
13.2
10.1
7.41
(9.96 12.0)
(9.33 12.7)
(8.72 13.6)
(8.92 15.1)
(7.36 11.3)
(2.71 8.77)
21.1
19.5
22.1
23.1
19.3
16.2
(20.1 22.2)
(18.2 20.5)
(19.9 23.4)
(21.5 24.9)
(17.8 20.7)
(13.9 19.3)
34.4
32.1
34.0
35.1
32.7
31.3
(32.2 37.6)
(28.9 36.1)
(32.7 35.5)
(32.1 44.4)
(28.9 39.9)
(25.2 56.0)
883
145
313
198
122
105
19.0
20.4
19.4
19.7
18.1
15.5
(18.4 19.5)
(18.9 22.0)
(18.6 20.3)
(18.6 20.8)
(16.8 19.6)
(14.0 17.2)
10.5
11.4
11.8
10.8
10.0
7.98
(10.0 11.0)
(9.53 13.4)
(10.1 12.2)
(9.95 12.7)
(9.01 11.0)
(5.24 10.5)
19.4
21.2
20.0
20.0
18.0
16.0
(18.5 20.2)
(19.3 23.0)
(19.4 20.9)
(18.5 23.4)
(16.9 19.1)
(13.3 18.1)
33.3
32.5
32.9
34.1
32.8
26.7
(32.1 34.1)
(31.2 35.0)
(31.5 35.7)
(32.5 36.7)
(30.5 34.5)
(25.0 31.2)
961
150
333
251
124
103
Males
Females
162
162
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
22.0
25.6
24.8
25.7
20.4
14.3
(20.9 23.2)
(23.3 28.2)
(23.5 26.2)
(24.2 27.2)
(19.1 21.8)
(13.1 15.7)
10.8
13.7
14.3
14.5
9.89
6.20
(9.77 11.8)
(11.1 17.0)
(12.9 15.4)
(12.4 15.6)
(8.68 10.8)
(4.94 6.93)
23.5
27.0
25.8
26.3
21.3
15.3
(22.6 24.7)
(24.6 28.9)
(23.6 27.4)
(25.0 27.8)
(19.9 23.3)
(14.5 16.5)
40.0
41.8
41.6
42.4
38.6
31.2
(39.1 41.7)
(38.7 45.9)
(39.1 44.9)
(39.6 47.1)
(36.2 43.4)
(27.5 35.7)
1,891
240
665
368
335
283
23.1
26.2
25.5
28.0
20.5
14.6
(21.9 24.3)
(23.4 29.2)
(24.1 27.0)
(26.5 29.6)
(18.3 22.9)
(13.3 15.9)
11.2
16.4
14.9
15.3
9.19
5.56
(9.87 12.4)
(10.4 18.0)
(13.5 16.1)
(13.6 16.8)
(6.70 10.9)
(4.94 6.14)
24.9
27.0
26.2
27.9
22.1
15.5
(23.3 26.4)
(23.4 29.8)
(23.9 27.8)
(26.2 30.2)
(18.9 26.4)
(15.0 17.1)
41.8
40.1
43.2
47.8
38.6
32.1
(39.8 44.9)
(38.4 46.3)
(39.5 51.7)
(42.5 52.7)
(35.6 51.3)
(30.0 38.1)
949
128
343
170
156
152
21.2
25.1
24.1
23.8
20.3
14.1
(19.8 22.7)
(22.4 28.1)
(21.9 26.6)
(21.8 26.1)
(19.2 21.6)
(12.1 16.5)
10.6
12.4
13.9
13.6
9.99
6.71
(9.30 11.6)
(9.15 15.1)
(10.5 15.5)
(10.9 15.7)
(9.03 11.3)
(3.54 7.89)
22.5
26.7
24.8
25.0
20.9
15.0
(21.1 23.7)
(24.9 28.9)
(22.1 27.6)
(22.1 27.2)
(18.1 23.3)
(13.0 17.4)
39.0
42.1
39.8
39.1
39.0
28.1
(37.2 41.0)
(38.4 49.7)
(36.6 43.9)
(37.4 41.6)
(34.8 44.3)
(24.6 39.1)
942
112
322
198
179
131
Males
Females
Geometric mean
10th
50th
90th
Sample
size
21.3
21.4
21.6
24.6
22.3
16.6
(20.8 21.9)
(19.6 23.4)
(20.6 22.6)
(23.6 25.6)
(20.9 23.9)
(15.6 17.6)
10.8
11.1
13.0
13.7
11.7
7.32
(10.1 11.3)
(9.63 12.9)
(11.1 13.7)
(11.4 16.4)
(9.54 13.0)
(6.45 8.11)
23.0
22.1
22.1
25.6
24.2
18.0
(22.4 23.5)
(20.4 24.0)
(21.4 22.7)
(24.8 26.4)
(22.9 25.3)
(16.9 19.2)
39.1
37.5
37.0
40.7
40.5
34.2
(37.5 40.6)
(33.7 42.4)
(35.0 39.9)
(39.6 42.3)
(38.3 42.2)
(32.3 37.0)
2,973
231
499
714
683
846
21.9
22.6
21.8
25.7
22.8
16.3
(21.0 22.9)
(20.7 24.6)
(20.6 23.2)
(24.2 27.2)
(20.6 25.2)
(15.0 17.8)
11.3
12.8
13.2
14.8
11.8
7.49
(10.3 11.9)
(8.41 14.9)
(10.0 14.3)
(11.8 17.1)
(8.02 14.0)
(6.36 8.08)
23.6
23.0
22.5
26.5
25.0
17.7
(22.7 24.8)
(21.1 24.8)
(21.1 24.3)
(25.1 28.4)
(23.2 27.0)
(16.0 19.2)
39.6
38.3
36.6
41.5
41.2
33.7
(37.9 41.6)
(33.4 43.2)
(35.8 38.4)
(39.6 46.1)
(38.1 44.0)
(31.3 37.0)
1,472
112
254
309
351
446
20.8
20.1
21.3
23.5
21.8
16.9
(20.0 21.7)
(17.6 23.1)
(19.4 23.3)
(22.5 24.5)
(20.3 23.6)
(15.8 18.0)
10.2
9.66
12.7
13.0
11.7
7.00
(9.48 11.1)
(4.60 12.9)
(9.21 14.2)
(10.2 16.2)
(9.46 12.9)
(6.17 8.28)
22.4
20.7
21.6
24.6
23.4
18.3
(21.5 23.1)
(19.2 23.2)
(20.3 23.5)
(23.3 25.3)
(21.4 25.3)
(17.1 20.1)
38.5
36.7
37.2
40.2
39.7
34.4
(36.5 40.3)
(30.8 50.0)
(33.9 41.5)
(35.9 42.7)
(37.9 41.1)
(32.1 38.5)
1,501
119
245
405
332
400
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
163
163
20.6
21.2
(19.9 21.3)
(20.7 21.7)
7.87
7.81
(7.49 8.27)
(7.33 8.40)
22.2
22.7
(21.3 23.1)
(22.2 23.2)
42.5
43.6
(41.0 43.9)
(42.4 44.9)
7,921
7,254
20012002
16.1
(15.2 17.1)
6.16
(3.73 7.47)
17.3
(16.2 18.1)
33.9
(32.8 37.9)
427
20012002
20052006
21.6
21.7
(20.7 22.5)
(20.5 22.9)
9.31
9.48
(8.20 9.83)
(7.38 10.9)
22.7
22.5
(21.4 23.6)
(21.1 23.7)
40.5
42.8
(37.7 47.0)
(40.0 46.0)
1,012
860
20012002
20052006
21.6
21.9
(21.1 22.1)
(21.1 22.6)
10.5
9.91
(9.69 11.1)
(8.98 11.0)
22.2
22.3
(21.8 22.7)
(21.8 22.9)
40.5
42.6
(38.1 43.2)
(40.2 45.1)
2,205
1,954
20012002
20052006
22.7
23.9
(21.5 23.9)
(23.3 24.4)
10.3
10.7
(9.02 11.5)
(8.97 11.4)
23.7
25.1
(22.5 24.9)
(24.3 25.6)
44.9
46.1
(42.4 47.1)
(44.1 47.2)
1,714
1,688
20012002
20052006
21.1
21.6
(20.1 22.1)
(20.4 22.8)
7.82
7.69
(7.02 8.61)
(6.02 8.98)
22.7
23.2
(21.4 24.1)
(22.1 24.4)
42.6
44.6
(41.2 43.8)
(42.5 47.1)
1,468
1,365
20012002
20052006
15.4
16.4
(14.6 16.3)
(15.4 17.4)
4.15
5.19
(2.92 5.13)
(4.32 5.97)
17.1
17.8
(16.1 17.9)
(16.8 19.0)
39.0
38.8
(36.4 41.3)
(37.3 40.7)
1,522
1,387
20012002
20052006
21.4
21.8
(20.6 22.3)
(21.0 22.6)
8.02
7.85
(7.31 8.80)
(6.99 8.89)
23.3
23.4
(22.3 24.2)
(22.6 24.3)
44.2
44.7
(42.8 46.3)
(43.7 47.0)
3,832
3,547
20012002
20052006
19.8
20.6
(19.2 20.5)
(20.0 21.2)
7.82
7.76
(7.13 8.34)
(7.09 8.40)
21.2
22.2
(20.4 22.0)
(21.5 22.6)
40.3
42.3
(38.9 42.1)
(41.2 43.9)
4,089
3,707
20012002
20052006
20.0
19.5
(19.2 20.8)
(19.1 20.0)
8.89
8.80
(7.84 9.62)
(7.83 9.29)
20.7
20.2
(20.1 21.7)
(19.6 20.9)
39.8
38.0
(38.1 42.0)
(36.4 40.2)
1,987
1,844
20012002
20052006
21.7
22.0
(21.0 22.3)
(20.9 23.2)
8.03
8.11
(6.83 9.11)
(7.39 8.77)
23.4
23.5
(22.2 24.3)
(22.6 24.7)
46.6
47.0
(44.9 49.0)
(44.7 49.5)
1,864
1,891
20012002
20052006
20.8
21.3
(20.1 21.6)
(20.8 21.9)
8.17
7.69
(7.55 8.72)
(7.04 8.47)
22.4
23.0
(21.3 23.5)
(22.4 23.5)
42.5
43.8
(40.9 44.0)
(42.4 45.2)
3,446
2,973
Age group
35 years
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
Race/ethnicity
164
164
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
50
95th Percentile
45
i
i
i
40
i
i
35
30
25
i
i
50th Percentile
i
i
i
i
i
i
i
i
20
15
12
i
0506
i
i
0102
0506
0102
0506
0102
0506
0102
6
4
Total
(6+y)
35y
611y
1219y
20+y
Males
(6+y)
Females
(6+y)
MA
(6+y)
NHB
(6+y)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
0506
0506
0102
0506
0102
0506
0102
0506
0102
0506
2
0102
5th Percentile
0102
10
NHW
(6+y)
165
165
166
166
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
36.2
41.3
39.6
40.6
38.2
39.7
39.5
43.8
40.5
31.5
39.4
(35.3 37.1)
(39.2 43.5)
(38.6 40.6)
(39.3 42.0)
(37.1 39.3)
(37.5 42.0)
(38.2 40.8)
(42.7 44.9)
(38.2 42.9)
(29.8 33.2)
(38.5 40.2)
Geometric mean
13.7
12.9
10.9
11.4
11.1
14.9
15.4
15.9
10.6
8.08
11.3
(11.8 14.3)
(10.9 14.2)
(9.72 12.5)
(9.28 13.2)
(10.3 12.9)
(10.7 17.8)
(12.9 17.4)
(14.0 17.8)
(7.35 13.2)
(6.96 9.57)
(10.4 12.6)
2.5th
16.6
16.7
15.1
15.6
15.3
18.8
19.1
20.0
15.0
10.7
15.4
(15.3 17.9)
(14.3 18.0)
(14.2 16.0)
(13.9 17.3)
(14.2 16.4)
(15.1 19.9)
(17.2 20.9)
(17.0 21.8)
(12.4 17.1)
(9.50 12.4)
(14.6 16.1)
5th
37.4
43.1
42.4
43.5
40.1
40.9
40.6
45.2
43.1
33.5
41.8
(36.1 38.9)
(41.1 45.5)
(41.3 43.3)
(42.2 44.7)
(38.9 41.6)
(38.5 44.1)
(39.6 42.0)
(43.8 46.6)
(41.1 45.3)
(31.4 35.9)
(41.0 42.6)
50th
70.5
86.4
81.1
84.5
77.6
78.4
73.9
83.3
84.1
72.8
80.8
(67.0 74.0)
(83.0 89.5)
(78.9 82.9)
(81.6 86.9)
(75.1 80.5)
(74.8 82.5)
(71.5 79.0)
(81.4 86.1)
(79.9 89.2)
(69.5 76.4)
(78.8 82.5)
95th
79.3
97.2
89.7
95.2
86.0
83.0
82.8
92.7
97.2
81.7
(74.1 91.3)
(91.5 107)
(87.2 94.8)
(89.9 103)
(81.9 92.1)
(80.6 105)
(78.1 93.4)
(87.4 99.3)
(90.7 103)
(76.3 89.4)
(87.9 94.7)
97.5th
90.7
1,818
1,846
2,943
3,493
3,656
851
1,907
1,667
1,346
1,378
7,149
Sample
size
Geometric mean and selected percentiles of serum concentrations (in g/dL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20052006.
Mexican Americans
20
40
Females
Males
60
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
40
20
0
60
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
60
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
167
167
Geometric mean
10th
50th
90th
Sample
size
39.4
39.7
39.5
43.8
40.5
31.5
(38.5 40.2)
(37.5 42.0)
(38.2 40.8)
(42.7 44.9)
(38.2 42.9)
(29.8 33.2)
20.5
21.5
23.5
24.6
21.0
14.3
(19.5 21.3)
(19.3 25.4)
(21.8 24.6)
(21.9 27.2)
(18.6 22.9)
(13.3 15.9)
41.8
40.9
40.6
45.2
43.1
33.5
(41.0 42.6)
(38.5 44.1)
(39.6 42.0)
(43.8 46.6)
(41.1 45.3)
(31.4 35.9)
71.2
67.6
66.3
74.0
72.8
62.8
(69.5 72.7)
(63.5 74.9)
(63.1 69.6)
(72.5 75.8)
(70.3 77.1)
(60.2 67.5)
7,149
851
1,907
1,667
1,346
1,378
40.6
41.4
40.1
46.4
41.2
31.3
(39.3 42.0)
(39.2 43.8)
(38.5 41.8)
(44.5 48.5)
(37.7 45.0)
(29.1 33.7)
21.2
23.7
23.8
26.8
20.9
14.3
(20.1 22.2)
(20.3 26.4)
(21.3 26.0)
(22.9 30.6)
(15.2 23.9)
(12.6 15.9)
43.5
42.1
41.1
48.3
44.9
34.4
(42.2 44.7)
(39.7 44.9)
(40.0 42.5)
(45.5 51.0)
(42.6 47.1)
(31.6 36.4)
72.9
69.5
66.3
78.5
75.0
62.0
(70.9 75.6)
(63.4 78.2)
(64.6 69.4)
(74.6 81.9)
(71.0 81.4)
(59.0 69.3)
3,493
421
955
730
663
724
38.2
37.9
38.8
41.3
39.8
31.6
(37.1 39.3)
(34.8 41.3)
(36.2 41.5)
(40.2 42.4)
(37.6 42.1)
(29.7 33.5)
19.9
19.4
23.4
22.6
20.9
14.2
(18.8 21.1)
(16.3 24.7)
(20.0 24.6)
(20.7 26.2)
(18.9 22.8)
(12.9 16.4)
40.1
39.8
40.1
42.7
41.1
33.0
(38.9 41.6)
(35.7 43.9)
(37.8 42.7)
(41.5 43.7)
(37.8 45.0)
(30.8 35.8)
69.3
66.2
65.3
71.6
71.3
64.6
(67.0 71.7)
(59.8 74.0)
(60.1 72.6)
(66.4 74.0)
(68.8 75.6)
(58.0 69.7)
3,656
430
952
937
683
654
Males
Females
Geometric mean
10th
50th
90th
Sample
size
36.2
35.5
35.7
38.8
34.8
29.9
(35.3 37.1)
(33.8 37.3)
(34.5 37.0)
(36.5 41.1)
(32.7 37.1)
(27.3 32.8)
20.5
21.0
21.8
22.7
19.6
14.7
(19.5 21.7)
(18.7 22.5)
(19.6 23.4)
(18.7 24.7)
(17.4 21.1)
(11.9 17.9)
37.4
35.5
37.4
41.0
35.1
30.1
(36.1 38.9)
(33.8 37.3)
(36.0 38.7)
(39.1 42.5)
(32.6 38.5)
(27.9 33.8)
61.5
58.4
58.5
63.8
60.7
54.7
(58.8 63.5)
(55.7 63.1)
(55.6 61.8)
(58.8 71.2)
(57.3 65.5)
(48.8 65.8)
1,818
292
639
441
240
206
37.6
34.4
36.9
41.3
35.6
29.9
(36.3 39.0)
(32.6 36.4)
(34.6 39.4)
(37.8 45.1)
(32.6 38.8)
(25.1 35.7)
21.4
20.2
22.5
24.6
19.0
14.5
(19.9 23.0)
(17.8 22.4)
(19.2 24.6)
(16.6 27.7)
(14.4 22.6)
(5.80 18.2)
39.2
34.3
39.1
42.6
36.4
30.2
(36.9 40.8)
(31.7 36.1)
(36.8 40.7)
(40.6 45.6)
(33.4 40.5)
(26.0 36.1)
63.1
57.4
59.7
66.1
58.7
61.9
(59.5 68.0)
(50.5 73.4)
(55.9 63.9)
(58.3 94.4)
(56.0 74.3)
(48.0 86.3)
867
142
310
192
120
103
34.8
36.7
34.5
35.9
34.0
29.9
(33.8 35.8)
(34.4 39.1)
(33.2 35.8)
(33.9 38.1)
(31.6 36.7)
(27.3 32.8)
20.0
21.1
20.6
20.2
19.6
16.1
(18.7 21.4)
(17.7 24.4)
(19.0 22.6)
(17.5 22.7)
(16.1 21.4)
(12.1 20.5)
35.3
36.7
34.8
37.4
33.0
29.2
(33.5 37.3)
(34.3 40.4)
(33.8 36.8)
(33.3 41.9)
(30.2 38.3)
(26.6 35.7)
59.5
58.8
57.8
61.4
61.0
52.7
(56.8 62.0)
(56.3 62.2)
(51.9 62.0)
(56.1 68.6)
(55.9 67.8)
(48.0 59.9)
951
150
329
249
120
103
Males
Females
168
168
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
10th
50th
90th
Sample
size
41.3
47.9
44.3
47.0
39.2
28.2
(39.2 43.5)
(43.3 52.9)
(42.3 46.4)
(44.2 50.1)
(36.4 42.2)
(26.0 30.6)
21.4
27.4
26.9
26.4
20.0
12.7
(19.5 23.1)
(20.5 31.8)
(23.9 29.0)
(23.2 29.6)
(17.1 21.4)
(10.4 15.4)
43.1
49.6
45.8
49.0
40.8
29.1
(41.1 45.5)
(44.6 56.3)
(42.8 47.8)
(45.5 52.3)
(37.7 43.4)
(26.6 32.7)
75.5
78.5
73.1
79.6
73.7
59.0
(72.1 79.6)
(73.9 84.4)
(69.2 78.2)
(76.1 82.9)
(66.9 84.2)
(53.0 68.4)
1,846
236
636
363
331
280
43.6
49.5
45.7
51.6
40.0
28.9
(41.0 46.3)
(44.4 55.1)
(43.1 48.6)
(48.4 55.1)
(35.3 45.3)
(26.5 31.6)
22.9
30.6
28.9
29.7
18.4
12.5
(19.5 24.5)
(15.3 35.9)
(25.6 30.2)
(25.9 31.9)
(13.2 22.9)
(11.1 13.0)
45.8
50.4
46.7
51.4
41.1
31.1
(42.8 48.4)
(42.4 58.7)
(43.6 50.4)
(48.1 54.9)
(36.8 47.4)
(28.3 34.7)
81.2
76.8
76.3
86.3
82.9
59.5
(76.4 87.8)
(70.9 91.8)
(69.3 90.2)
(81.2 90.5)
(67.2 97.5)
(52.9 66.0)
922
126
324
169
153
150
39.3
46.3
42.9
43.4
38.6
27.7
(37.0 41.8)
(41.2 52.1)
(39.5 46.4)
(39.8 47.3)
(36.3 41.0)
(24.1 31.9)
20.8
24.6
25.6
23.6
20.1
12.8
(18.5 22.2)
(17.9 27.5)
(20.1 28.1)
(21.0 28.0)
(17.1 21.5)
(8.09 17.2)
41.0
48.5
44.1
44.5
40.2
28.6
(39.4 43.0)
(44.6 54.8)
(39.8 48.0)
(40.4 50.6)
(36.7 43.0)
(24.8 32.4)
71.4
78.5
70.4
72.6
68.6
57.6
(68.7 74.1)
(72.8 84.6)
(67.3 75.3)
(68.4 76.7)
(63.6 75.8)
(45.4 82.2)
924
110
312
194
178
130
Males
Females
Geometric mean
10th
50th
90th
Sample
size
39.6
39.3
39.2
44.8
41.6
31.7
(38.6 40.6)
(35.9 43.1)
(37.5 40.9)
(43.2 46.5)
(38.8 44.6)
(30.0 33.5)
20.4
20.7
23.3
25.3
22.2
14.4
(19.4 21.3)
(18.9 24.9)
(20.8 24.8)
(21.5 29.3)
(17.8 24.4)
(13.3 16.2)
42.4
40.6
40.7
45.9
44.7
33.9
(41.3 43.3)
(37.7 44.9)
(39.3 42.1)
(44.0 48.4)
(42.6 47.0)
(31.7 36.7)
71.5
64.8
66.2
75.4
73.9
62.9
(69.4 73.8)
(58.7 78.0)
(62.8 70.2)
(72.5 77.8)
(70.4 78.5)
(60.2 67.4)
2,943
230
489
706
674
844
40.7
41.5
39.8
47.2
42.6
31.2
(39.2 42.3)
(38.1 45.3)
(37.1 42.6)
(44.7 49.8)
(38.4 47.1)
(28.6 34.0)
21.0
23.6
23.2
26.8
22.4
14.4
(19.7 22.0)
(19.7 26.4)
(19.9 27.0)
(21.7 31.6)
(15.0 27.3)
(12.3 16.1)
43.9
42.3
41.0
49.4
46.3
33.9
(42.5 45.2)
(39.5 45.7)
(38.4 43.0)
(45.9 52.3)
(44.0 49.0)
(30.8 36.5)
73.2
66.0
66.3
78.7
75.3
62.0
(70.9 76.0)
(58.8 81.5)
(63.5 69.8)
(73.9 85.0)
(70.9 82.7)
(58.8 69.7)
1,461
111
251
308
346
445
38.5
37.0
38.6
42.5
40.7
32.2
(36.9 40.1)
(32.7 41.8)
(35.1 42.3)
(40.6 44.4)
(37.6 44.0)
(30.3 34.2)
19.7
19.1
23.6
22.9
21.6
14.3
(18.2 21.3)
(13.7 25.3)
(18.0 25.6)
(19.9 28.7)
(17.5 24.5)
(12.9 16.6)
40.7
39.1
40.4
43.2
42.4
33.8
(38.9 42.5)
(33.8 43.3)
(37.0 43.4)
(41.9 44.2)
(39.0 47.4)
(31.6 37.1)
69.6
61.9
64.4
72.1
72.1
64.5
(66.8 72.6)
(54.6 78.0)
(57.9 75.6)
(66.5 77.0)
(68.7 78.7)
(59.0 68.7)
1,482
119
238
398
328
399
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
169
169
References
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Albanes D, Heinonen OP, Taylor PR, Virtamo J, Edwards BK, Rautalahti M, et al. Alpha-tocopherol and betacarotene supplement and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study:
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Al-Delaimy WK, Ferrari P, Slimani N, Pala V, Johansson I, Nilsson S, et al. Plasma carotenoids as biomarkers of
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Bailey RL, Gahche JJ, Lentino CV, Dwyer JT, Engel JS, Thomas PT, et al. Dietary Supplement Use in the United
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Ballew C, Bowman BA, Sowell AL, Gillespie C. Serum retinol distributions in residents of the United States: Third
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Bendich A, Langseth L. Safety of vitamin A. Am J Clin Nutr. 1989 Feb;49(2):358-71.
Boylston T, Nollet LML. Chemical and biochemical aspects of color in muscle foods. In: Perez-Alvarez JA and
Fernandez-Lopez J, editors. Handbook of meat, poultry and seafood quality. Ames (IA): Blackwell Publishing;
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Britton G, Liaaen-Jensen S, Pfander H., editors. Carotenoids handbook. Basel (Switzerland): Birkhuser; 2004.
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Ford ES, Sowell A. Serum -tocopherol status in the United States population: findings from the Third National
Health and Nutrition Examination Survey. Am J Epidemiol. 1999;150:290300.
Ford ES. Variations in serum carotenoid concentrations among United States adults by ethnicity and sex. Ethn Dis.
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Ford ES, Gillespie C, Ballew C, Sowell A, Mannino DM. Serum carotenoid concentrations in U.S. children and
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Ford ES, Schleicher RL, Mokdad AH, Ajani UA, Liu S. Distribution of serum concentrations of alpha-tocopherol
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Institute of Medicine, Food and Nutrition Board. Dietary reference intakes: vitamin C, vitamin E, selenium, and
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Institute of Medicine, Food and Nutrition Board. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron,
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2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
171
171
Vitamin D
Background Information
Sources and Physiological Functions. Vitamin D (calciferol) comprises a group of fat soluble
seco-sterols found naturally in only a few foods, such as fish-liver oils, fatty fishes, mushrooms, egg
yolks, and liver. The two major physiologically relevant forms of vitamin D are D2 (ergocalciferol)
and D3 (cholecalciferol). Vitamin D3 is photosynthesized in the skin of vertebrates by the action
of solar ultraviolet (UV) B radiation on 7-dehydrocholesterol present in the skin (Fieser 1959).
Vitamin D2 is produced by UV irradiation of ergosterol, which occurs in molds, yeast, and higherorder plants. Under conditions of regular sun exposure, dietary vitamin D intake is of minor
importance. However, latitude, season, aging, sunscreen use, and skin pigmentation influence the
production of vitamin D3 by the skin (Institute of Medicine 2011). In the United States, most
of the dietary intake of vitamin D comes from fortified milk products and other fortified foods
such as breakfast cereals and orange juice (Institute of Medicine 2011). Both vitamin D2 and D3
are used in nonprescription vitamin D supplements, but vitamin D2 is the only form available by
prescription in the United States (Holick 2007).
Vitamin D without a subscript represents either D2 or D3 or both. Vitamin D, per se, is
biologically inert. Whether derived from the skin or diet, vitamin D is only short-lived in
circulation (with a half-life of 12 days), as it is either stored in fat cells or metabolized in the liver
(Mawer 1972). In circulation, vitamin D is bound to vitamin D-binding protein and transported
to the liver, where it is converted to 25-hydroxyvitamin D [25(OH)D] (DeLuca 1984). This
major circulating form of vitamin D is a good reflection of cumulative effects of exposure
to sunlight and dietary intake of vitamin D (Haddad 1973; Holick 1995) and is therefore
used by clinicians to determine vitamin D status. To be biologically activated at physiologic
concentrations, 25(OH)D must be converted in the kidneys to 1,25-dihydroxyvitamin D
[1,25(OH)2D], which is thought to be responsible for most, if not all, of the biologic functions
of vitamin D (DeLuca 1988; Reichel 1989). The production of 25(OH)D in the liver is a
function of vitamin D availability from dietary intake and sun exposure whereas production of
1,25(OH)2D in the kidney is tightly regulated by mineral requirements. In the liver, vitamin
D-25-hydroxylase is down-regulated by vitamin D and its metabolites, thereby limiting any
increase in the circulating concentration of 25(OH)D following intakes or following production
of vitamin D after exposure to sunlight. In the kidney, in response to serum calcium and
phosphorus concentrations, the production of 1,25(OH)2D is regulated through the action of
parathyroid hormone (PTH) (DeLuca 1988; Reichel 1989).
Health Effects. Active vitamin D (1,25-dihydroxyvitamin D) functions as a hormone, and its
main biologic function in people is to maintain serum calcium and phosphorus concentrations
within the normal range by enhancing the efficiency of the small intestine to absorb these
minerals from the diet (DeLuca 1988; Reichel 1989). When dietary calcium intake is inadequate
to satisfy the bodys calcium requirement, 1,25(OH)2D, along with PTH, mobilizes calcium
stores from the bone. In the kidney, 1,25(OH)2D increases calcium reabsorption by the distal
renal tubules. Apart from these traditional calcium-related actions, 1,25(OH)2D and its synthetic
analogs are increasingly recognized for their potent anti-proliferative, pro-differentiative, and
immunomodulatory activities (Nagpal 2005).
Vitamin D deficiency is characterized by inadequate mineralization or by demineralization of
the skeleton. Among children, vitamin D deficiency is a common cause of bone deformities
known as rickets. Vitamin D deficiency in adults leads to a mineralization defect in the skeleton,
172
172
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
causing osteomalacia, and it induces secondary hyperparathyroidism with consequent bone loss
and osteoporosis. Potential roles for vitamin D beyond bone health, such as effects on muscle
strength, the risk for cancer, and the risk for type 2 diabetes, are under intense investigation. The
Agency for Healthcare Research and Quality (AHRQ) reviewed the effectiveness and safety of
vitamin D on outcomes related to bone health (Cranney 2007). The report suggests that vitamin
D supplementation has positive effects on bone health in postmenopausal women and older men.
Another AHRQ systematic review of vitamin D status and health outcomes found no significant
associations between vitamin D status and total cancer mortality, nor did it find any conclusive
evidence for the association of vitamin D status with cancer risk or cancer outcome (Chung
2009). It also found no clear association between vitamin D status and cardiometabolic outcomes
including fasting glucose, blood pressure, myocardial infarction or stroke. Randomized trials
showed no clinically significant consistent effects of vitamin D supplementation at the dosages
given (Pittas 2010).
Intake Recommendations. What constitutes the optimal intake of vitamin D remains a matter
of some disagreement. Current recommendations from the Institute of Medicine (2011) call for
400 international units (IU) [10 micrograms (g)] of vitamin D daily from birth through age
1 year for adequate intake (AI)]. The Recommended Dietary Allowance (RDA) for those aged
170 years is 600 IU (15 g) and 800 IU (20 g) for those older than 70 years. According to
the Dietary Guidelines for Americans (U.S. Department of Agriculture and U.S. Department of
Health Human Services 2010), moderate evidence shows that intake of milk and milk products is
linked to improved bone health, especially in children and adolescents. In the United States, most
dietary vitamin D is obtained from fortified foods, especially milk. The Tolerable Upper Intake
Level for vitamin D is 4000 IU (100 g) per day in North America for individuals 9 years of age
and older and ranges from 1000 IU to 3000 IU for infants and children less than 9 years of age; as
intake increases above this amount, the potential risk for adverse consequences increases.
Biochemical Indicators and Methods. To assess vitamin D status, one measures the
concentration of 25(OH)D in serum, using either antibody-based methods such as radioisotope-,
enzyme-linked- or chemiluminescence- immunoassays, or using chemistry-based methods such
as HPLC separation with UV or tandem mass spectrometry detection. Studies have shown that
standardized chemistry-based methods are equivalent but that antibody-based methods may show
significant bias. Some clinical laboratories use conventional units for 25(OH)D (nanogram per
milliliter [ng/mL]), whereas other laboratories use
international system (SI) units (nanomole per liter
[nmol/L]). The conversion factor to SI units is:
1 ng/mL = 2.5 nmol/L.
The Institute of Medicine (2011) committee to
review dietary reference intakes for vitamin D and
calcium suggested that persons with serum 25(OH)
D concentrations of less than 30 nmol/L (12 ng/mL)
are at risk for deficiency; those with concentrations
of at least 30 but less than 50 nmol/L (12 to less
than 20 ng/mL) are at risk for inadequacy; and those
with concentrations between 5075 nmol/L (2030
ng/mL) are considered sufficient. The Committee
indicated that concentrations greater than 125 nmol/L
(50 ng/mL) may be reason for concern. Of interest
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
173
173
to public health scientists, the report indicated that a serum 25(OH)D level consistent with the
Estimated Average Requirement for dietary intake (EAR) lies between 30 and 50 nmol/L and that
40 nmol/L was selected from the middle of the range to serve as the targeted level for median dietary
requirements (Institute of Medicine 2011).
A number of external quality assurance programs exist for serum or plasma 25(OH)D
concentration measurements, including those sponsored by DEQAS (Vitamin D External
Quality Assessment Scheme), College of American Pathologists (Bone and Growth Survey and
Accuracy-Based Vitamin D Survey), and NIST/NIH (Vitamin D Metabolites Quality Assurance
Program). Standard reference materials (SRM 972) with certified values for 25(OH)D2, 25(OH)
D3 and C3-epimer of 25(OH)D3 are available from the U.S. National Institute of Standards and
Technology (NIST). An additional solvent-based reference material set (SRM 2972) with certified
values for 25(OH)D2 and 25(OH)D3 is also available (https://www-s.nist.gov/srmors/view_detail.
cfm?srm=972). Further improvement in the agreement between laboratories and methods is
expected as more laboratories use these SRMs.
Data in NHANES. The data in this report were obtained by use of an antibody-based method,
specifically a radioimmunoassay (DiaSorin, Stillwater, MN). The manufacturer reformulated the
kit in the late 1990s, resulting in data that were on average 12% lower than those generated with
the original kit. To make NHANES III data (original kit) comparable to data from 20012006
(reformulated kit), we followed the recommendations of a panel of experts (Yetley 2010) to use
a published adjustment equation for the NHANES III data (see Analytic Note at http://www.
cdc.gov/nchs/nhanes/nhanes2005-2006/VID_D.htm). The Analytic Note also reported that
the reformulated kit showed some assay drifts between 2001 and 2006. To generate 20032004
and 20052006 tables and figures, we used the public release data files from November 2010.
Using data that were already adjusted for these assay drifts was the most appropriate way to make
comparisons across survey cycles.
Since 1988, NHANES has monitored the vitamin D status of the U.S. population. By design,
this survey collects information and biological samples in the summer from people living at higher
latitudes and in the winter from people living at lower latitudes. Because the different racial and
ethnic groups are not evenly distributed across all geographic regions in the United States, the
season-latitude structure of the survey can affect comparisons by race or ethnicity. In two seasonal
subpopulations from NHANES III (19881994), Looker et al. (2002) showed that in the winter
and lower latitude subpopulation, 15% and 2557% had 25(OH)D concentrations less than
25 nmol/L (10 ng/mL) and less than 62.5 nmol/L (25 ng/mL), respectively. In the summer and
higher latitude subpopulation, 13% and 2149% had 25(OH)D concentrations below these
cutoffs. Mean 25(OH)D concentrations were highest in non-Hispanic whites, intermediate in
Mexican Americans, and lowest in non-Hispanic blacks. A more recent analysis of NHANES
III and NHANES 20002004 (Looker 2008) demonstrated that overall, mean serum 25(OH)
D were 59 nmol/L lower in 20002004 than in 19881994 in most males, but not in most
females. Factors related to changes in vitamin D status were increased body mass index, decreased
milk intake, and increased usage of sun protection in the more recent surveys.
For more information about vitamin D, see the Institute of Medicines Dietary Reference Intake
reports (Institute of Medicine 2011), fact sheets from the National Institutes of Health, Office of
Dietary Supplements
(http://ods.od.nih.gov/Health_Information/Information_About_Individual_Dietary_
Supplements.aspx).
174
174
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Highlights
Serum 25-hydroxyvitamin D [25(OH)D] concentrations in the U.S. population showed the
following demographic patterns and characteristics:
Concentrations generally decreased with increasing age.
No consistent pattern was observed with regard to gender.
Among the three race/ethnic groups, non-Hispanic blacks had the lowest 25(OH)D
concentrations and non-Hispanic whites had the highest concentrations.
The likelihood of being vitamin D deficient was significantly influenced by race/
ethnicity.
During the past several years, the vitamin D status of the U.S. population was under intensive
investigation to determine whether a downward trend was apparent. In the analysis below, we
used data that were adjusted for radioimmunoassay reformulation and assay drifts according to
recommendations made by a panel of experts (Yetley 2010). The age-adjusted mean 25(OH)D
concentrations in the U.S. population decreased by approximately 10% between NHANES III
and the periods 20012002 and 20032006 (Figure H.2.b). Decreases were seen in all groups
shown (total or stratified by gender or race/ethnicity). Similarly, a recent report found that the
age- and season-adjusted prevalence at risk of deficiency (serum 25(OH)D concentrations less
than 30 nmol/L) increased between 19881994 and 20012002 from 4% to 7% for males aged
12 years and older and from 7% to 11% for females aged 12 years and older (Looker 2011).
1988-1994
2001-2002
2003-2006
80
70
60
a
b
a
b
50
b
a
40
30
20
10
0
Total
population
Males
Females
Mexican
American
NonHispanic
NonHispanic
black
white
Figure H.2.b. Age-adjusted geometric mean concentrations of serum 25-hydroxyvitamin D in the U.S. population aged 12 years and
older by gender or race/ethnicity, National Health and Nutrition Examination Survey, 19882006.
Error bars represent 95% confidence intervals. Within a demographic group, bars not sharing a common letter differ (p < 0.05). Age adjustment was
done using direct standardization.
It is interesting to note that non-Hispanic blacks one year and older had the highest prevalence
of vitamin D deficiency (serum 25(OH)D concentrations less than 30 nmol/L) (Figure H.2.c),
despite clinical data showing superior bone health with greater density and fewer fractures than
other race/ethnic groups; further research is needed to explain this unusual finding (Aloia 2008).
Higher peak bone mass, higher obesity rates, greater muscle mass and lower bone turnover
are some of the factors that have been suggested to protect African Americans against fracture
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
175
175
(Aloia 2008). Non-Hispanic blacks and Mexican Americans had the highest prevalence of low
serum 25(OH)D concentrations categorized at risk for inadequacy (30 to less than 50 nmol/L)
compared to non-Hispanic whites (Figure H.2.c).
45
40
35
Prevalence (%)
30
25
c
20
15
10
c
5
0
Mexican
American
NonHispanic
NonHispanic
black
white
Mexican
American
< 30 nmol/L
NonHispanic
NonHispanic
black
white
30 to < 50 nmol/L
Figure H.2.c. Age-adjusted prevalence estimates of serum 25-hydroxyvitamin D concentrations less than 30 and 30 to less than 50
nmol/L in the U.S. population aged 1 year and older by race/ethnicity, National Health and Nutrition Examination Survey, 2003
2006.
Error bars represent 95% confidence intervals. Within each vitamin D status category, bars not sharing a common letter differ (p < 0.05). Age
adjustment was done using direct standardization.
The Institute of Medicine (2011) report concluded that serum 25(OH)D levels of 40 nmol/L
are at a level consistent with a desirable median intake of vitamin D. Non-Hispanic blacks had
significantly higher prevalence of serum concentrations less than 40 nmol/L (Figure H.2.d) which
corresponds to the targeted level for the median dietary requirement. The median meets the
requirement of approximately half the population thus individuals with concentrations less than
40 nmol/L are at increased risk of adverse health outcomes.
70
b
60
Prevalence (%)
50
40
30
20
c
10
0
Mexican American
Non-Hispanic black
Non-Hispanic white
< 40 nmol/L
Figure H.2.d. Age-adjusted prevalence estimates of serum 25-hydroxyvitamin D concentrations less than 40 nmol/L in the U.S.
population aged 1 years and older by race/ethnicity, National Health and Nutrition Examination Survey, 20032006.
Error bars represent 95% confidence intervals. Bars not sharing a common letter differ (p < 0.05). Age adjustment was done using direct
standardization.
176
176
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Detailed Observations
The selected observations mentioned below are derived from the tables and figures presented next.
Statements about categorical differences between demographic groups noted below are based on
non-overlapping confidence limits from univariate analysis without adjusting for demographic
variables (e.g., age, gender, race/ethnicity) or other blood concentration determinants (e.g., dietary
intake, supplement usage, smoking, BMI). A multivariate analysis may alter the size and statistical
significance of these categorical differences. Furthermore, additional significant differences of
smaller magnitude may be present despite their lack of mention here (e.g., if confidence limits
slightly overlap or if differences are not statistically significant before covariate adjustment has
occurred). For a selection of citations of descriptive NHANES papers related to these biochemical
indicators of diet and nutrition, see Appendix G.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
177
177
178
178
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
48.7
36.1
61.9
56.7
54.5
68.6
63.8
55.1
54.5
53.6
54.1
55.6
(46.3 51.2)
(34.3 38.0)
(60.3 63.4)
(54.7 58.7)
(52.5 56.6)
(66.7 70.5)
(61.6 66.1)
(52.4 58.0)
(52.1 57.0)
(51.3 56.0)
(52.4 55.8)
(53.6 57.6)
Geometric mean
18.2
12.0
24.9
20.7
17.6
36.9
30.5
18.0
17.6
17.8
19.1
18.5
(16.8 19.4)
(11.0 12.8)
(23.3 25.9)
(18.6 22.3)
(16.2 18.5)
(32.9 38.8)
(27.3 31.6)
(15.6 20.1)
(15.9 19.0)
(16.3 18.9)
(18.1 20.1)
(17.4 19.7)
2.5th
21.5
14.3
31.0
25.8
21.2
41.6
35.3
22.7
21.8
21.7
23.1
23.2
(19.6 23.3)
(13.5 15.1)
(29.1 32.6)
(23.8 27.3)
(19.8 22.5)
(39.5 43.4)
(32.0 38.7)
(19.8 25.1)
(20.3 23.3)
(19.8 23.6)
(21.6 24.6)
(21.4 25.0)
5th
49.9
36.6
63.2
58.9
57.2
68.8
64.5
57.6
56.6
56.0
56.9
58.0
(47.7 53.4)
(34.2 39.1)
(61.8 64.6)
(57.1 60.7)
(55.2 59.2)
(66.9 70.6)
(63.0 66.1)
(55.3 60.1)
(54.4 58.9)
(54.1 58.1)
(55.4 58.5)
(56.3 59.9)
50th
81.8
70.9
102
94.0
99.4
99.6
97.2
98.4
102
94.3
91.9
96.6
(79.2 84.7)
(68.5 73.7)
(97.8 106)
(90.7 97.7)
(96.1 106)
(95.7 107)
(92.5 108)
(94.3 108)
(97.2 108)
(90.5 98.3)
(89.5 95.0)
(93.9 101)
95th
88.2
79.0
113
103
112
107
105
111
115
103
100
(85.4 92.0)
(74.9 82.2)
(110 117)
(98.6 109)
(108 117)
(102 121)
(98.4 122)
(106 123)
(110 122)
(98.0 110)
(96.6 106)
(105 112)
97.5th
108
4,275
4,349
6,698
8,145
8,459
1,799
1,768
4,044
3,262
2,660
3,071
16,604
Sample
size
Geometric mean and selected percentiles of serum concentrations (in nmol/L) for the total U.S. population aged 1 year and older, National Health
and Nutrition Examination Survey, 20032006.
80
Mexican Americans
20
40
60
Females
Males
Serum 25hydroxyvitamin D
(nmol/L)
Overall
15
611
1219
2039
4059
60+
15
611
4059
60+
4059
60+
20
40
60
80
NonHispanic Whites
15
611
1219
2039
4059
60+
15
611
1219
2039
Males
80
Females
20
40
60
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum 25hydroxyvitamin D
(nmol/L)
2039
Serum 25hydroxyvitamin D
(nmol/L)
NonHispanic Blacks
1219
15
611
1219
2039
Age (years)
4059
60+
15
611
1219
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
179
179
Geometric mean
5th
50th
95th
Sample
size
55.6
68.6
63.8
55.1
54.5
53.6
54.1
(53.6 57.6)
(66.7 70.5)
(61.6 66.1)
(52.4 58.0)
(52.1 57.0)
(51.3 56.0)
(52.4 55.8)
23.2
41.6
35.3
22.7
21.8
21.7
23.1
(21.4 25.0)
(39.5 43.4)
(32.0 38.7)
(19.8 25.1)
(20.3 23.3)
(19.8 23.6)
(21.6 24.6)
58.0
68.8
64.5
57.6
56.6
56.0
56.9
(56.3 59.9)
(66.9 70.6)
(63.0 66.1)
(55.3 60.1)
(54.4 58.9)
(54.1 58.1)
(55.4 58.5)
96.6
99.6
97.2
98.4
102
94.3
91.9
(93.9 101)
(95.7 107)
(92.5 108)
(94.3 108)
(97.2 108)
(90.5 98.3)
(89.5 95.0)
16,604
1,799
1,768
4,044
3,262
2,660
3,071
56.7
69.2
65.5
56.6
53.7
55.8
55.6
(54.7 58.7)
(67.0 71.5)
(63.2 67.9)
(54.0 59.3)
(51.4 56.1)
(53.3 58.4)
(53.7 57.7)
25.8
41.7
36.9
25.3
23.6
25.3
26.0
(23.8 27.3)
(40.1 43.5)
(32.5 40.3)
(22.5 28.0)
(20.9 25.7)
(22.4 27.0)
(23.8 27.9)
58.9
69.3
65.8
58.7
55.9
58.0
57.5
(57.1 60.7)
(66.7 71.6)
(64.3 67.6)
(56.4 61.2)
(53.7 57.8)
(55.8 60.8)
(55.6 59.7)
94.0
101
98.0
95.2
90.6
92.4
91.9
(90.7 97.7)
(96.7 106)
(92.4 116)
(88.8 105)
(87.7 96.7)
(88.1 98.7)
(89.1 97.2)
8,145
904
862
2,049
1,472
1,311
1,547
54.5
67.9
61.9
53.6
55.3
51.6
52.9
(52.5 56.6)
(65.8 70.0)
(59.6 64.4)
(50.6 56.9)
(52.4 58.3)
(49.2 54.2)
(51.1 54.7)
21.2
41.3
34.0
20.6
20.5
19.4
21.7
(19.8 22.5)
(37.4 44.3)
(31.4 37.6)
(18.0 22.9)
(19.1 21.8)
(18.3 20.6)
(20.2 23.2)
57.2
68.4
62.8
56.4
57.6
54.1
56.4
(55.2 59.2)
(66.3 70.3)
(60.1 65.3)
(53.1 59.5)
(54.4 60.7)
(50.8 57.0)
(54.5 58.2)
99.4
98.1
96.4
106
110
95.1
92.0
(96.1 106)
(93.3 113)
(92.5 103)
(96.5 114)
(106 116)
(91.5 99.2)
(89.1 95.8)
8,459
895
906
1,995
1,790
1,349
1,524
Males
Females
Geometric mean
5th
95th
48.7
64.8
56.9
46.8
46.6
44.4
45.0
(46.3 51.2)
(63.1 66.6)
(55.0 58.8)
(44.2 49.6)
(43.6 49.7)
(41.4 47.7)
(42.4 47.8)
21.5
42.5
32.7
22.0
20.6
19.4
20.1
(19.6 23.3)
(39.4 44.7)
(30.9 34.9)
(20.2 23.4)
(17.6 23.5)
(17.4 21.2)
(17.6 21.4)
49.9
64.3
58.2
47.8
48.0
45.8
45.9
(47.7 53.4)
(62.3 66.1)
(56.3 59.8)
(45.6 50.7)
(45.4 51.5)
(41.9 49.0)
(43.6 48.1)
81.8
93.8
82.9
74.8
78.0
79.8
79.5
(79.2 84.7)
(89.5 99.7)
(80.7 86.9)
(71.2 83.6)
(75.6 83.1)
(72.4 87.7)
(73.4 89.5)
4,275
584
589
1,288
789
472
553
51.1
65.2
58.8
49.5
49.1
47.4
48.0
(48.7 53.7)
(63.9 66.5)
(56.8 60.8)
(46.6 52.6)
(45.5 52.8)
(44.0 51.0)
(44.0 52.2)
24.5
44.6
36.0
23.8
24.3
20.9
21.4
(21.7 26.6)
(40.5 45.8)
(32.3 38.8)
(21.5 26.2)
(19.7 26.2)
(15.3 25.9)
(18.3 25.0)
52.7
64.4
59.7
50.0
49.8
47.4
48.3
(49.4 55.5)
(63.1 65.6)
(57.8 62.3)
(47.4 54.0)
(47.1 54.1)
(44.6 54.3)
(43.6 54.3)
81.7
94.9
83.3
78.0
77.0
79.8
81.2
(79.0 85.2)
(88.6 109)
(80.5 92.2)
(72.7 85.8)
(73.1 86.5)
(72.2 92.8)
(74.4 96.7)
2,073
282
286
641
353
239
272
46.2
64.5
54.8
44.1
43.9
41.5
42.7
(43.7 48.8)
(61.8 67.2)
(52.3 57.5)
(41.4 47.1)
(40.7 47.3)
(37.9 45.3)
(39.6 46.1)
19.8
40.5
31.1
20.4
18.5
18.7
19.1
(18.9 20.6)
(36.0 44.3)
(25.0 33.7)
(17.3 22.5)
(16.4 20.4)
(17.5 20.0)
(15.4 21.1)
47.7
64.2
56.6
45.6
44.9
42.8
44.3
(45.4 50.3)
(59.9 67.5)
(54.0 58.8)
(42.4 48.0)
(41.6 48.2)
(37.3 46.8)
(40.5 47.0)
82.1
92.9
82.3
73.2
80.2
79.6
78.0
(78.6 85.4)
(89.1 98.6)
(74.5 93.8)
(67.7 80.3)
(74.8 87.1)
(70.9 85.0)
(71.5 88.9)
2,202
302
303
647
436
233
281
Males
Females
180
180
50th
Sample
size
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Geometric mean
5th
50th
95th
Sample
size
36.1
55.5
48.1
34.2
32.5
34.1
36.2
(34.3 38.0)
(52.7 58.5)
(45.7 50.6)
(31.4 37.2)
(30.4 34.8)
(32.0 36.3)
(34.1 38.3)
14.3
29.4
24.8
13.8
13.7
13.3
15.0
(13.5 15.1)
(21.0 33.4)
(23.4 25.7)
(13.0 14.6)
(12.7 14.8)
(11.6 14.8)
(13.2 15.9)
36.6
57.5
49.4
34.6
31.5
34.7
36.3
(34.2 39.1)
(54.5 59.6)
(47.3 52.2)
(31.3 38.2)
(29.2 34.2)
(32.4 37.7)
(33.8 39.7)
70.9
86.6
73.8
68.3
64.0
66.2
72.9
(68.5 73.7)
(82.1 91.3)
(71.5 80.2)
(64.2 72.2)
(61.1 70.4)
(62.0 71.6)
(67.6 80.3)
4,349
503
561
1,421
716
626
522
38.0
56.5
51.0
36.9
32.4
37.4
37.5
(35.9 40.3)
(52.5 60.7)
(48.1 54.1)
(34.0 40.0)
(29.8 35.1)
(34.8 40.2)
(34.9 40.3)
15.5
30.0
26.0
14.6
13.8
15.9
15.0
(14.0 16.6)
(21.7 34.0)
(23.0 28.4)
(13.2 15.9)
(11.6 15.2)
(14.0 17.1)
(12.8 16.6)
38.6
58.4
53.0
38.1
30.5
38.2
38.5
(35.9 41.4)
(54.3 61.6)
(49.3 56.5)
(34.9 41.0)
(28.4 33.3)
(34.2 42.2)
(34.7 42.7)
71.8
89.1
75.0
70.8
64.9
69.6
72.3
(69.0 78.6)
(81.9 98.4)
(70.5 88.7)
(66.6 75.9)
(59.0 82.3)
(62.4 77.2)
(66.1 79.2)
2,166
248
277
745
339
293
264
34.5
54.6
45.3
31.5
32.7
31.5
35.3
(32.7 36.3)
(51.2 58.2)
(42.3 48.4)
(28.8 34.5)
(30.4 35.1)
(29.2 34.0)
(32.8 37.9)
13.6
28.4
23.6
13.3
13.7
12.2
15.0
(12.9 14.3)
(13.2 35.2)
(19.4 25.3)
(12.5 14.2)
(11.8 15.1)
(10.5 13.2)
(13.0 15.8)
34.9
56.0
46.0
31.3
32.4
32.5
34.7
(32.4 37.7)
(53.3 58.8)
(42.4 49.7)
(27.7 34.3)
(29.3 36.2)
(28.6 35.2)
(31.6 39.3)
69.6
83.1
73.0
64.7
63.0
63.2
73.5
(65.9 73.0)
(79.7 94.4)
(71.0 76.9)
(59.3 71.5)
(60.6 70.6)
(58.7 75.3)
(64.4 96.3)
2,183
255
284
676
377
333
258
Males
Females
Geometric mean
5th
50th
95th
Sample
size
61.9
73.6
71.1
65.2
64.1
58.9
57.4
(60.3 63.4)
(71.3 76.0)
(68.2 74.1)
(63.0 67.4)
(61.8 66.5)
(56.8 61.0)
(55.9 58.9)
31.0
49.0
46.1
37.4
33.3
27.4
26.0
(29.1 32.6)
(44.1 51.7)
(43.5 48.1)
(35.6 40.1)
(29.8 36.3)
(25.9 30.2)
(24.2 27.7)
63.2
72.3
69.6
64.7
64.3
60.4
59.7
(61.8 64.6)
(70.7 74.2)
(67.5 71.8)
(62.9 66.6)
(61.8 66.6)
(58.0 63.2)
(58.3 61.1)
102
105
103
107
110
96.7
92.9
(97.8 106)
(97.8 118)
(96.1 119)
(100 113)
(107 115)
(92.5 103)
(90.8 97.2)
6,698
516
457
1,050
1,458
1,360
1,857
62.4
74.1
72.6
65.4
61.6
60.7
58.7
(60.8 64.1)
(71.7 76.6)
(69.1 76.3)
(63.2 67.7)
(59.5 63.8)
(58.5 63.0)
(56.9 60.5)
33.7
47.1
47.1
40.6
33.5
31.8
30.5
(31.8 35.4)
(41.5 52.3)
(41.6 52.5)
(37.3 42.7)
(30.7 36.5)
(28.4 34.0)
(26.7 33.3)
63.6
72.7
70.9
65.3
62.3
62.6
60.0
(62.1 65.0)
(70.4 74.8)
(68.0 74.8)
(63.5 67.1)
(59.6 64.7)
(59.9 64.8)
(58.1 61.5)
97.4
105
105
99.6
96.8
96.1
92.7
(93.9 103)
(99.2 116)
(96.4 136)
(93.5 112)
(90.9 104)
(90.0 104)
(90.1 98.7)
3,303
279
219
528
641
691
945
61.3
73.1
69.4
64.9
66.7
57.1
56.3
(59.6 63.1)
(69.8 76.5)
(66.6 72.4)
(61.7 68.3)
(63.5 70.0)
(54.6 59.7)
(54.6 58.0)
27.9
49.8
45.6
34.9
33.0
24.8
23.9
(25.6 30.3)
(45.5 52.8)
(42.7 47.6)
(31.1 37.5)
(26.4 37.1)
(19.9 27.0)
(22.0 25.7)
62.9
71.9
68.3
63.9
66.6
58.4
59.5
(61.0 64.5)
(69.3 75.8)
(65.6 70.8)
(61.4 67.0)
(63.5 69.6)
(55.6 61.9)
(57.8 61.2)
107
105
99.9
112
117
97.2
93.1
(102 111)
(94.9 122)
(94.8 109)
(106 127)
(112 128)
(93.4 105)
(90.0 99.8)
3,395
237
238
522
817
669
912
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
181
181
54.7
55.5
54.3
(52.6 56.8)
(52.5 58.7)
(51.5 57.3)
22.6
24.2
21.8
(20.4 24.9)
(20.9 26.3)
(20.1 23.5)
57.1
57.5
57.2
(55.1 59.3)
(54.7 60.6)
(54.8 59.7)
96.8
97.2
95.9
(92.4 105)
(92.8 104)
(91.9 103)
7,807
7,403
7,402
15 years
20032004
20052006
68.2
69.0
(65.9 70.5)
(65.7 72.5)
41.3
41.8
(37.6 44.4)
(39.3 44.0)
68.7
69.1
(66.8 70.6)
(64.7 72.1)
97.8
103
(96.3 101)
(94.2 121)
895
904
20012002
20032004
20052006
63.8
63.4
64.2
(60.5 67.3)
(60.2 66.7)
(60.8 67.7)
36.9
34.8
35.8
(31.9 39.7)
(31.2 40.5)
(31.9 38.6)
63.7
64.5
64.4
(60.4 66.8)
(61.8 66.9)
(62.6 66.8)
101
94.3
98.8
(90.1 138)
(87.5 109)
(92.5 129)
991
846
922
20012002
20032004
20052006
55.1
56.2
54.0
(52.5 57.8)
(52.2 60.6)
(50.1 58.3)
24.5
24.8
21.2
(20.8 27.2)
(21.0 27.3)
(17.6 23.9)
56.7
57.9
57.3
(54.2 59.1)
(53.9 61.8)
(54.0 60.7)
96.1
101
96.3
(91.8 102)
(94.1 112)
(88.6 111)
2,167
2,059
1,985
20012002
20032004
20052006
54.1
54.4
54.6
(51.8 56.5)
(50.9 58.1)
(51.1 58.4)
21.2
22.5
21.1
(19.4 23.1)
(19.0 25.4)
(19.0 23.3)
56.4
56.1
57.0
(54.0 59.0)
(51.9 59.9)
(54.2 60.1)
102
104
99.2
(94.8 110)
(95.9 110)
(95.5 113)
1,691
1,559
1,703
20012002
20032004
20052006
54.0
54.7
52.6
(51.4 56.6)
(51.1 58.5)
(49.6 55.9)
21.4
23.6
20.8
(18.7 24.4)
(18.7 26.9)
(18.8 22.8)
56.8
56.5
55.5
(54.6 59.8)
(53.6 60.2)
(52.9 58.4)
94.9
94.5
94.1
(90.5 104)
(89.0 102)
(88.9 100)
1,449
1,278
1,382
20012002
20032004
20052006
52.5
55.2
53.1
(49.9 55.3)
(52.9 57.5)
(50.4 55.9)
23.1
24.2
22.3
(21.1 24.4)
(21.8 25.8)
(20.4 24.3)
55.1
57.6
56.4
(52.4 57.7)
(55.2 59.7)
(54.1 58.9)
91.8
94.1
90.4
(88.4 95.0)
(90.1 102)
(87.5 93.9)
1,509
1,661
1,410
20012002
20032004
20052006
56.5
56.8
55.1
(54.5 58.6)
(53.6 60.2)
(52.4 58.0)
25.8
27.0
23.8
(23.8 27.2)
(23.7 29.4)
(21.5 25.6)
58.3
58.6
57.7
(56.3 60.7)
(55.8 61.7)
(55.7 60.1)
96.0
92.1
94.1
(91.2 105)
(88.8 98.2)
(88.1 102)
3,782
3,638
3,603
20012002
20032004
20052006
53.0
54.3
53.6
(50.6 55.5)
(51.4 57.3)
(50.5 56.9)
20.5
21.3
20.5
(18.0 22.7)
(19.2 23.5)
(18.6 22.3)
55.8
56.3
56.6
(53.5 58.1)
(53.3 59.5)
(53.8 59.5)
98.4
103
97.1
(92.6 108)
(97.3 109)
(93.1 107)
4,025
3,765
3,799
20012002
20032004
20052006
48.9
48.7
45.9
(46.2 51.8)
(46.0 51.6)
(41.9 50.2)
23.0
22.8
20.0
(21.3 24.5)
(19.4 25.5)
(16.3 22.6)
50.1
50.2
47.3
(47.1 52.7)
(47.1 53.4)
(43.3 52.8)
81.6
80.5
78.5
(77.3 91.2)
(77.2 84.1)
(73.0 84.5)
1,961
1,802
1,889
20012002
20032004
20052006
32.6
36.3
33.8
(31.3 34.0)
(33.5 39.4)
(31.6 36.2)
13.3
14.3
13.9
(10.9 14.4)
(12.8 15.6)
(13.0 14.8)
32.5
37.0
33.4
(31.1 34.2)
(34.0 40.7)
(30.7 37.1)
66.2
69.1
68.4
(63.9 68.5)
(65.8 73.9)
(64.5 71.1)
1,821
1,914
1,932
20012002
20032004
20052006
60.9
61.7
61.0
(58.7 63.1)
(59.3 64.2)
(59.0 63.1)
29.9
30.2
31.0
(28.2 31.2)
(27.0 33.6)
(27.5 32.4)
62.2
63.2
62.3
(60.2 64.2)
(60.8 65.2)
(60.3 64.1)
102
103
99.0
(95.9 110)
(97.3 109)
(95.9 108)
3,416
3,155
3,027
Age group
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
182
182
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
120
100
80
60
80
50th Percentile
70
60
50
40
30
50
30
20
Females
(6+y)
0102
0304
0506
Males
(6+y)
0102
0304
0506
20+y
0102
0304
0506
1219y
0102
0304
0506
611y
0102
0304
0506
15y
0102
0304
0506
0102
0304
0506
Total
(6+y)
0102
0304
0506
0102
0304
0506
10
0102
0304
0506
5th Percentile
40
MA
(6+y)
NHB
(6+y)
NHW
(6+y)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
183
183
16,604
8.1
(6.7 9.8)
23,004,000
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
1,799
1,768
4,044
3,262
2,660
3,071
0.7
1.8
8.5
9.5
9.3
8.8
(0.4 1.3)
(1.3 2.6)
(6.5 11.2)
(7.6 11.8)
(7.4 11.7)
(7.3 10.5)
146,000
442,000
2,823,000
7,538,000
7,343,000
4,084,000
Males
Females
8,145
8,459
6.3
9.9
(5.0 7.9)
(8.1 11.9)
8,735,000
14,288,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
4,275
4,349
6,698
11.3
31.1
3.6
(8.7 14.6)
(27.4 35.1)
(3.0 4.4)
2,919,000
10,623,000
6,929,000
Gender
Race/ethnicity
184
184
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
16,604
23.6
(21.6 25.8)
66,859,000
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
1,799
1,768
4,044
3,262
2,660
3,071
8.9
14.1
24.2
26.2
25.0
25.5
(7.1 11.0)
(11.5 17.2)
(21.3 27.3)
(23.6 29.0)
(22.2 28.0)
(23.7 27.4)
1,799,000
3,407,000
8,005,000
20,908,000
19,729,000
11,879,000
Males
Females
8,145
8,459
23.1
24.1
(20.8 25.6)
(22.1 26.3)
31,909,000
34,955,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
4,275
4,349
6,698
32.9
39.5
18.1
(29.6 36.4)
(37.3 41.7)
(16.2 20.2)
8,514,000
13,483,000
34,769,000
Gender
Race/ethnicity
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
185
185
16,604
17.2
(14.7 20.0)
49,431,000
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
1,799
1,768
4,044
3,262
2,660
3,071
2.7
5.7
17.1
19.7
20.0
17.8
(1.8 4.0)
(4.2 7.7)
(13.8 21.0)
(16.4 23.4)
(16.6 23.9)
(15.5 20.4)
541,000
1,358,000
5,729,000
15,722,000
16,400,000
8,602,000
Males
Females
8,145
8,459
14.6
19.6
(12.3 17.4)
(16.9 22.7)
20,576,000
28,869,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
4,275
4,349
6,698
24.4
51.6
9.4
(20.1 29.3)
(46.7 56.5)
(7.9 11.2)
6,635,000
17,968,000
18,114,000
Gender
Race/ethnicity
186
186
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
16,604
0.9
15 years
611 years
1219 years
2039 years
4059 years
60 years and older
1,799
1,768
4,044
3,262
2,660
3,071
1.4
1.5
0.6
0.3
(0.9 2.1)
(0.9 2.4)
(0.3 1.2)
(0.1 0.6)
450,000
1,193,000
498,000
134,000
Males
Females
8,145
8,459
0.4
1.3
(0.3 0.7)
(0.9 1.9)
587,000
1,867,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
4,275
4,349
6,698
1.2
Gender
Race/ethnicity
(0.6 1.2)
2,449,000
(0.8 1.7)
2,283,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
187
187
7,807
7,403
7,402
8.4
7.6
9.5
(6.8 10.3)
(5.5 10.5)
(7.3 12.2)
20032004
20052006
895
904
0.7
(0.3 1.5)
137,000
20012002
20032004
20052006
991
846
922
1.5
2.2
(0.8 2.6)
(1.4 3.5)
350,000
524,000
20012002
20032004
20052006
2,167
2,059
1,985
7.0
7.0
10.0
(4.4 11.1)
(4.6 10.7)
(6.8 14.5)
2,266,000
2,327,000
3,353,000
20012002
20032004
20052006
1,691
1,559
1,703
9.5
9.3
9.6
(7.7 11.5)
(6.6 12.8)
(6.9 13.3)
7,498,000
7,391,000
7,700,000
20012002
20032004
20052006
1,449
1,278
1,382
9.4
7.5
11.0
(7.2 12.2)
(4.8 11.4)
(8.3 14.5)
7,125,000
5,910,000
9,054,000
20012002
20032004
20052006
1,509
1,661
1,410
8.8
8.3
9.3
(6.7 11.3)
(6.1 11.1)
(7.2 11.8)
3,921,000
3,841,000
4,488,000
20012002
20032004
20052006
3,782
3,638
3,603
6.2
5.3
8.0
(4.9 7.9)
(3.5 8.1)
(6.0 10.6)
7,774,000
6,830,000
10,419,000
20012002
20032004
20052006
4,025
3,765
3,799
10.4
9.8
10.9
(8.2 13.0)
(7.3 13.1)
(8.2 14.2)
13,726,000
13,254,000
14,894,000
20012002
20032004
20052006
1,961
1,802
1,889
8.9
9.7
15.0
(6.7 11.6)
(7.1 13.3)
(10.2 21.5)
1,863,000
2,218,000
3,604,000
20012002
20032004
20052006
1,821
1,914
1,932
37.8
28.5
37.4
(34.5 41.2)
(22.6 35.2)
(32.2 42.9)
11,654,000
8,872,000
11,915,000
20012002
20032004
20052006
3,416
3,155
3,027
3.7
3.6
4.0
Age group
15 years
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
(2.9 4.7)
(2.6 4.9)
(3.1 5.1)
21,467,000
20,049,000
25,318,000
6,654,000
6,423,000
7,240,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
188
188
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,807
7,403
7,402
24.0
24.5
24.5
(21.7 26.4)
(21.2 28.1)
(21.7 27.5)
61,533,000
64,338,000
65,423,000
20032004
20052006
895
904
8.6
9.2
(6.4 11.5)
(6.5 12.8)
1,741,000
1,857,000
20012002
20032004
20052006
991
846
922
14.7
13.3
15.0
(10.9 19.6)
(9.4 18.4)
(11.5 19.3)
3,639,000
3,199,000
3,558,000
20012002
20032004
20052006
2,167
2,059
1,985
23.6
23.8
24.6
(20.4 27.1)
(19.4 28.9)
(20.8 28.8)
7,638,000
7,881,000
8,214,000
20012002
20032004
20052006
1,691
1,559
1,703
24.8
27.5
24.9
(21.8 28.1)
(23.1 32.4)
(21.9 28.1)
19,655,000
21,959,000
19,866,000
20012002
20032004
20052006
1,449
1,278
1,382
24.3
25.1
24.8
(21.3 27.5)
(21.0 29.6)
(20.8 29.4)
18,368,000
19,828,000
20,365,000
20012002
20032004
20052006
1,509
1,661
1,410
26.9
23.8
27.3
(23.0 31.2)
(21.6 26.0)
(24.1 30.6)
12,040,000
11,054,000
13,167,000
20012002
20032004
20052006
3,782
3,638
3,603
22.8
23.6
24.3
(20.4 25.4)
(19.8 27.9)
(21.2 27.8)
28,420,000
30,162,000
31,683,000
20012002
20032004
20052006
4,025
3,765
3,799
25.1
25.4
24.6
(22.5 27.9)
(22.1 28.9)
(21.6 27.8)
33,130,000
34,190,000
33,739,000
20012002
20032004
20052006
1,961
1,802
1,889
35.6
34.9
35.5
(31.0 40.5)
(30.6 39.5)
(30.0 41.3)
7,496,000
7,963,000
8,515,000
20012002
20032004
20052006
1,821
1,914
1,932
40.0
42.2
39.0
(37.5 42.6)
(38.1 46.3)
(36.1 42.0)
12,350,000
13,140,000
12,422,000
20012002
20032004
20052006
3,416
3,155
3,027
18.7
18.6
18.9
(16.6 21.0)
(15.6 22.1)
(16.0 22.2)
33,627,000
33,594,000
34,271,000
Age group
15 years
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
189
189
7,807
7,403
7,402
18.2
17.2
18.9
20032004
20052006
895
904
3.0
2.3
(1.6 5.5)
(1.4 3.7)
612,000
467,000
20012002
20032004
20052006
991
846
922
5.3
5.8
5.6
(3.2 8.7)
(3.4 9.7)
(4.0 7.9)
1,313,000
1,399,000
1,338,000
20012002
20032004
20052006
2,167
2,059
1,985
17.5
15.3
18.9
(13.2 22.8)
(11.2 20.6)
(13.8 25.4)
5,660,000
5,078,000
6,325,000
20012002
20032004
20052006
1,691
1,559
1,703
19.7
19.9
19.5
(16.2 23.6)
(15.1 25.6)
(14.9 25.2)
15,557,000
15,829,000
15,587,000
20012002
20032004
20052006
1,449
1,278
1,382
19.1
18.5
21.5
(16.0 22.7)
(13.6 24.6)
(16.8 27.0)
14,488,000
14,620,000
17,595,000
20012002
20032004
20052006
1,509
1,661
1,410
20.9
16.4
19.1
(16.9 25.7)
(13.4 20.0)
(15.5 23.4)
9,371,000
7,646,000
9,241,000
20012002
20032004
20052006
3,782
3,638
3,603
14.8
14.2
16.6
(12.6 17.3)
(10.4 19.1)
(13.4 20.4)
18,450,000
18,138,000
21,606,000
20012002
20032004
20052006
4,025
3,765
3,799
21.4
20.0
21.0
(18.1 25.3)
(15.9 24.8)
(16.8 26.0)
28,325,000
26,932,000
28,849,000
20012002
20032004
20052006
1,961
1,802
1,889
23.3
24.5
28.9
(19.0 28.2)
(19.1 30.8)
(21.3 37.9)
4,904,000
5,582,000
6,943,000
20012002
20032004
20052006
1,821
1,914
1,932
60.6
51.0
57.7
(57.1 64.1)
(43.9 58.1)
(50.3 64.7)
18,708,000
15,900,000
18,374,000
20012002
20032004
20052006
3,416
3,155
3,027
10.4
9.5
10.1
(8.6 12.4)
(7.0 12.8)
(8.1 12.6)
18,638,000
17,121,000
18,342,000
Age group
15 years
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
190
190
(15.5 21.3)
(13.3 21.9)
(15.3 23.1)
46,723,000
45,025,000
50,461,000
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7,807
7,403
7,402
0.8
1.0
0.8
20032004
20052006
895
904
20012002
20032004
20052006
991
846
922
20012002
20032004
20052006
2,167
2,059
1,985
1.3
1.4
(0.7 2.3)
(0.7 2.9)
427,000
478,000
20012002
20032004
20052006
1,691
1,559
1,703
1.0
1.7
1.3
(0.6 1.8)
(0.8 3.4)
(0.7 2.4)
821,000
1,334,000
1,050,000
20012002
20032004
20052006
1,449
1,278
1,382
0.8
(0.4 1.6)
616,000
20012002
20032004
20052006
1,509
1,661
1,410
20012002
20032004
20052006
3,782
3,638
3,603
0.5
(0.2 1.0)
649,000
20012002
20032004
20052006
4,025
3,765
3,799
1.1
1.5
1.1
(0.7 1.7)
(0.8 2.9)
(0.7 1.9)
1,395,000
2,071,000
1,574,000
20012002
20032004
20052006
1,961
1,802
1,889
20012002
20032004
20052006
1,821
1,914
1,932
20012002
20032004
20052006
3,416
3,155
3,027
1.0
1.3
1.1
Age group
15 years
611 years
1219 years
2039 years
4059 years
Gender
Females
Race/ethnicity
Non-Hispanic Blacks
Non-Hispanic Whites
(0.5 1.2)
(0.5 1.7)
(0.6 1.2)
(0.7 1.5)
(0.7 2.5)
(0.7 1.7)
1,998,000
2,547,000
2,224,000
1,859,000
2,391,000
2,047,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
191
191
References
Aloia JF. African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox. Am J Clin Nutr.
2008;88(2):545S550S.
Chung M, Balk EM, Brendel M, Ip S, Lau J, Lee J, et al. Vitamin D and calcium: Systematic review of health
outcomes. Evid Rep Technol Assess No. 183. AHRQ Publication No. 09-E015, Rockville, MD: Agency for
Healthcare Research and Quality. August 2009.
Cranney A, Horsley T, ODonnell S, Weiler HA, Puil L, Ooi DS, et al. Effectiveness and safety of vitamin D in
relation to bone health. Evid Rep Technol Assess No. 158 AHRQ Publication No. 07-E013, Rockville, MD:
Agency for Healthcare Research and Quality. August 2007.
DeLuca HF. The metabolism, physiology, and function of vitamin D. In: Kumar R, editor. Vitamin D: basic and
clinical aspects. Boston (MA): M. Nijhoff Publishers; 1984. pp. 168.
DeLuca HF. The vitamin D story: a collaborative effort of basic science and clinical medicine. FASEB J.
1988;2:224236.
Fieser LF, Fieser M. Vitamin D. In: Steroids. 1st ed. New York: Reinhold Publishing Corporation;1959. pp.
90168.
Haddad JG, Hahn TJ. Natural and synthetic sources of circulating 25-hydroxy-vitamin D in man. Nature.
1973;244:515517.
Holick MF. Vitamin D: photobiology, metabolism, and clinical applications. In: DeGroot LJ, editor.
Endocrinology, Vol 2, 3rd ed. Philadelphia (PA): WB Saunders; 1995. pp. 9901013.
Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266281.
Institute of Medicine. Food and Nutrition Board. Dietary reference intakes for calcium and vitamin D.
Washington, D.C.: National Academies Press; 2011.
Looker AC, Dawson-Hughs B, Calvo MS, Gunter EW, Sayhoun NR. Serum 25-hydroxyvitamin D status of
adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002;30:771777.
Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA. Serum 25-hydroxyvitamin D status
of the US population: 19881994 compared with 20002004. Am J Clin Nutr. 2008;88:15191527.
Looker AC, Johnson CL, Lacher DA, Pfeiffer CM, Schleicher RL, Sempos CT. Vitamin D status: United States,
20012006. NCHS Data Brief, No 59. Hyattsville, MD: National Center for Health Statistics. 2011.
Mawer EB, Blackhouse J, Holman CA, Lumb GA, Stanbury DW. The distribution and storage of vitamin D and
its metabolites in human tissues. Clin Sci. 1972;43:413431.
Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005;26:662
687.
Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, et al. Systematic review: Vitamin D and
cardiometabolic outcomes. Ann Intern Med. 2010;152:307314.
Reichel H, Koeffler HP, Norman AW. The role of vitamin D endocrine system in health and disease. N Engl J Med.
1989;320:980991.
U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for
Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, December 2010 [cited 2011].
Available at: http://www.cnpp.usda.gov/DGAs2010-PolicyDocument.htm.
Yetley EA, Pfeiffer CM, Schleicher RL, Phinney KW, Lacher DA, Christakos S, et al. NHANES monitoring of
serum 25-hydroxyvitamin D: a roundtable summary. J Nutr. 2010;140:2030S2045S.
192
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2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Fatty Acids
Background Information
Nomenclature. Fatty acids are organic acids characterized by long unbranched aliphatic tails (428 carbons) attached to a carboxyl group. Fatty acids usually possess an even number of carbon
atoms; and the carbon chain may contain several unsaturated or exclusively saturated bonds. Thus,
fatty acids differ in chain length, degree of saturation, location of the double bond(s) along the
chain, and whether the orientation of hydrogen atoms adjacent to the double bond is cis or trans.
Fatty acids with no double bonds are referred to as saturated fatty acids (SFA) while those with
one double bond are monounsaturated fatty acids (MUFA). Fatty acids with two or more double
bonds are termed polyunsaturated fatty acids (PUFA). PUFA are most often categorized into two
groups distinguished by a difference in location of the first double bond from the methyl end of
the acyl chain, namely, n-6 and n-3. Linoleic acid (18:2n-6) and alpha-linolenic acid (18:3n-3)
are representatives of these two groups. Each contains 18 carbon atoms but differs in the number
of double bonds (18:2n-6 vs 18:3n-3) and the location of the first double bond (18:2n-6 vs
18:3n-3). In this report, unless marked, all unsaturated fatty acids are assumed to be in the cis
configuration.
Sources and Physiological Functions. Good sources of PUFA include soybean, corn and
cottonseed oils (U.S. Department of Agriculture and U.S. Department of Health and Human
Services 2010). Oils that are rich in MUFA include olive, canola and safflower oils (U.S.
Department of Agriculture and U.S. Department of Health and Human Services 2010). Recent
NHANES data provide information on the major food sources of various fatty acids consumed
in the United States (U.S. National Institutes of Health 2010a and 2010b). Chicken dishes,
desserts, salad dressings, chips, nuts, seeds and pizza are the main sources of n-6 PUFA. The main
sources of n-3 PUFA (C18:3n-3) in the American diet are salad dressings, chicken dishes, desserts,
pizza, bread, mayonnaise and pasta dishes; whereas, the main sources of long-chain n-3 PUFA
(C20:5n-3 and C22:6n-3) are fish and fish mixed dishes. The chief dietary sources of MUFA
(C18:1) are desserts, meats, nuts, seeds, pizza, French fries and Mexican foods. The main sources
of SFA in the American diet are full-fat cheese, pizza and desserts; other sources include chicken
dishes, cured meats, ribs and burgers.
Triacylglycerols (triglycerides), the basic building blocks of fats and oils, are made up of three
fatty acids esterified to a glycerol molecule (Lichtenstein 2005). They are usually composed of 23
different kinds of fatty acids per molecule. During digestion, dietary triglycerides from animal
and vegetable fats are hydrolyzed in the small intestine to release free fatty acids. These acids
enter the intestinal cells and are used to resynthesize triglycerides, which become incorporated
into large lipoprotein particles called chylomicrons; these in turn are released into the lymph
prior to entering the plasma. Fatty acids with 10 or fewer carbon atoms can be absorbed from
the gut directly into the bloodstream where they are bound to albumin in the plasma. At distal
sites, triglycerides are again hydrolyzed by lipases before fatty acids can enter cells for further
metabolism. Once inside peripheral cells, free fatty acids provide an immediate source of energy
(fatty acids are the bodys major fuel source) or act as substrate for the biosynthesis of signaling
molecules such as eicosanoids. Free fatty acids are also incorporated into other lipid classes,
such as phospholipids, sphingolipids, and cholesteryl esters, or they may be resynthesized into
triglycerides and stored for later use. Phospholipids, which are critical structural components of
cellular membranes, tend to incorporate unsaturated fatty acids and so serve as a reservoir for
MUFA and PUFA.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
193
193
Humans are incapable of de novo synthesis of n-6 and n-3 PUFA because they lack the ability to
insert a double bond any closer than 9 carbons from the methyl end. Thus, linoleic (18:2n-6)
and alpha-linolenic (18:3n-3) acid are called essential PUFA in that they are required for good
health but must be derived from food sources rather than through endogenous biosynthesis or
metabolism. Both of these fatty acids are metabolized to longer-chain, more highly unsaturated
forms. Note that SFA and MUFA in plasma are not expected to closely reflect dietary intake
because these two classes of fatty acids can be endogenously synthesized from carbohydrates. The
strongest correlations with dietary intake are provided by plasma concentrations of n-3 PUFA and
trans-fatty acids (Sun 2007).
Health Effects. The most common MUFA is oleic acid (C18:1n-9); although humans can
synthesize this fatty acid, it is obtained largely through the diet. Evidence suggests that replacing
dietary carbohydrates with MUFA decreases LDL-cholesterol concentration, but there is little
evidence that MUFA are associated with coronary heart disease (Astrup 2011). Currently, intense
debate surrounds the question whether reduction in dietary SFA reduces risk of cardiovascular
disease (Zelman 2011). At present, the Dietary Guidelines for Americans recommend reduced intake
of SFA (U.S. Department of Agriculture and U.S. Department of Health and Human Services
2010). Restricting fat intake and replacing SFA with other nutrients has revealed added complexity
in the diet-heart issue. According to evidence from human studies, replacing SFA with PUFA lowers
coronary heart disease risk, whereas replacing SFA with carbohydrate either has no benefit (Micha
2010) or may be harmful or beneficial depending upon the quality of the carbohydrate (Jakobsen
2009; Jakobsen 2010). Carbohydrates either rapidly or slowly increase blood glucose; highly refined
carbohydrates are amongst the former, and higher intake of these is associated with greater risk for
development of diabetes. Replacing SFA with highly refined carbohydrates and added sugars may be
increasing heart disease risk through promotion of obesity and diabetes (Hu 2010).
The heart healthy effects of PUFA are most often assessed based on their effects on the concentrations
of total cholesterol, HDL- and LDL-cholesterol, cholesterol ratios and/or triglycerides. Intake of n-6
PUFA helps to lower total cholesterol and LDL-cholesterol, however, high intake of n-6 fatty acids may
suppress HDL-cholesterol levels. In contrast, n-3 fatty acid consumption has been shown to maintain
and even increase HDL status (International Life Sciences Institute 2001). In the United States, the
FDA permits qualified health claims to be made about a diet-disease relationship for cardiovascular
disease; currently, 6 of the 7 permitted claims for cardiovascular disease are related to the MUFA or
PUFA content of nuts, oils and spreads, or fish oil supplements.
Deficiency in the essential fatty acids is determined by use of a plasma triene-to-tetraene ratio
(eicosatrienoic [C20:3n-9]:arachidonic [C20:4n-6] acid); a ratio greater than 0.2 indicates deficiency
(Institute of Medicine 2005). (Note: eicosatrienoic was not part of the plasma fatty acid profile
measured for NHANES 2003-2004.) PUFA deficiency may manifest with neuropathy and skin
problems, such as rough or scaly skin and dermatitis (International Life Sciences Institute 2001).
Intake Recommendations. Because the body makes more than enough SFA to meet metabolic
needs, people have no requirement for these fatty acids. Evidence suggests that SFA are positively
associated with total cholesterol and LDL-cholesterol concentrations and thus with cardiovascular
disease risk. Lowering dietary intake of SFA to no more than 10% of caloric intake and replacing
them with MUFA and PUFA is recommended to reduce the risk of cardiovascular disease; moreover,
lowering the percentage of calories derived from SFA to 7% of calories, can further reduce risk of
cardiovascular disease (U.S. Department of Agriculture and U.S. Department of Health and Human
Services 2010; Cleeman 2001). The National Cholesterol Education Program Expert Panel on
Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III) recommends
194
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2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
that MUFA not exceed 20% of calories (Cleeman 2001). Guidance about adequate intake (AI) is
available for the essential fatty acids. The AI of linoleic acid is 17 g/d for men and 12 g/d for women.
For alpha-linolenic acid, the AI is 1.6 g/d for men and 1.1 g/d for women. Moderate evidence shows
that consumption of about 8 oz of seafood per week, which provides an average of 250 mg per day
of eicosapentaenoic acid (C20:5n-3) and docosahexaenoic acid (C22:6n-3), reduces cardiac deaths
among persons with and without cardiovascular disease (U.S. Department of Agriculture and U.S.
Department of Health and Human Services 2010). This amount of seafood is also associated with
improved infant health outcomes such as visual and cognitive development, when consumed by
pregnant or lactating women (U.S. Department of Agriculture and U.S. Department of Health and
Human Services 2010). Currently, there is not enough evidence to establish upper tolerable limits
for n-3 or n-6 PUFA (Institute of Medicine 2005).
According to the American Heart Association, patients with coronary heart disease should
be encouraged to increase their consumption of eicosapentaenoic acid (C20:5n-3) and
docosahexaenoic acid (C22:6n-3) to about 1 gram per day preferably from oily fish. The
American Heart Association Dietary Guidelines recommend at least two servings of fish per week
(particularly fatty fish) for patients without documented coronary heart disease. In addition,
inclusion of vegetable oils (e.g., soybean, canola, walnut, flaxseed) and food sources (e.g., walnuts,
flaxseeds) high in alpha-linolenic acid (C18:3n-3) is recommended in a healthy diet for the general
population (Kris-Etherton 2002). The American Heart Association recommends 5-10% of energy
from n-6 fatty acids (Harris 2009) while Adult Treatment Panel III recommends up to 10% of
total calories may be consumed from polyunsaturated fats (Cleeman 2001).
Biochemical Indicators and Methods. The long term fatty acid content of the diet is best
represented by the adipose tissue triglyceride content owing to the two-year half-life of adipose tissue
fatty acids. Erythrocytes, due to their 120 day half-life, reflect
intermediate term (weeks-to-months) dietary intake, although
this idea has been challenged by data demonstrating large changes
in the fatty acid composition of erthyrocytes within days of
altering dietary fat intake (Hodson 2008). Serum or plasma
concentrations represent more recent intake (days-to-weeks).
Few studies have compared the fatty acid composition of plasma
with red blood cells to assess which substrate best reflects dietary
intake. In one study, fatty acid correlations with food frequency
questionnaire data were only slightly stronger for erythrocytes
than for plasma (Sun 2007). The triglyceride fraction of plasma
appears to demonstrate the greatest day-to-day variation of any
circulating lipid fraction. Thus, whenever serum or plasma is
collected for fatty acid analysis, fasting is preferred to minimize
the within- and between-person variability at the time of
specimen collection.
Capillary gas chromatography (GC) is the technique most frequently used to separate fatty acids
for quantitative analysis. Detection methods include flame ionization or electron capture negative
chemical ionization mass spectrometry. Internal standards are used to correct for losses during
sample preparation and improve the accuracy and precision of measurements.
Data in NHANES. The data in this report were generated for fasted ( 8 hours) adults ( 20
years) by use of gas chromatography-mass spectrometry (GC-MS) based on a modification of the
method of Lagerstedt et al. (2001). Plasma fatty acid concentrations are reported in mol/L units.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
195
195
Generally, fatty acid data are expressed as percentage by weight of total fatty acids (wt%) although
percentage by mole (mol%) would be more meaningful. The possible advantages of using absolute
concentrations of individual fatty acids have not been well investigated (Hodson 2008). No data
exist on plasma concentrations of fatty acids in NHANES prior to 2003. This report shows firsttime NHANES data for 24 plasma fatty acids including 6 SFA, 7 MUFA, and 11 PUFA; these
data were acquired using surplus plasma from NHANES 2003-2004. The serum specimens were
stored at -70C until fatty acids were measured during the period 20102011. Based on limited
information in the literature about absolute concentrations, these 24 fatty acids are estimated to
comprise at least 90% of the total fatty acids circulating in the plasma in all lipid classes (fatty
acyls, glycerolipids, glycerophospholipids, sphingolipids and sterols). All unsaturated fatty acids
are assumed to be in the cis configuration; trans-fatty acids were not measured.
For more information about polyunsaturated fatty acids, see the Institute of Medicines Dietary Reference Intake reports (Institute of Medicine 2005) and fact sheets from the National Institutes of Health,
Office of Dietary Supplements (http://ods.od.nih.gov/FactSheets/Omega3FattyAcidsandHealth.asp).
Highlights
These first-time plasma concentrations of saturated (SFA), monounsaturated (MUFA), and
polyunsaturated (PUFA) fatty acids in the U.S. population showed the following demographic
patterns and characteristics:
In general, fatty acids circulated at lower concentrations in younger adults.
Plasma concentrations of individual fatty acids were generally similar in men and women.
No consistent race/ethnic pattern was observed for plasma fatty acid concentrations,
however heart-healthy polyunsaturated fatty acids showed race/ethnic differences.
All three classes of fatty acids contained representatives at low (< 100 mol/L) and high
concentrations (> 1,000 mol/L) (Figure H.2.e).
196
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2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
10,000
Monounsaturated
Saturated
Polyunsaturated
1,000
100
10
-6
:2n
18 6
:4n
20 6
:3n
20 3
:6n
22 3
:3n
18 6
:3n
18 3
:5n
20 3
:5n
22 6
:4n
22 6
:2n
20 6
:5n
22 9
:1n
18 7
:1n
16 7
:1n
18
-9
:1n
24 9
:1n
20 5
:1n
14 9
:1n
22
:0
:0
18
16
:0
14
:0
22
:0
24
:0
20
Figure H.2.e. Geometric mean plasma concentrations of individual fatty acids in the U.S. population from fasted adults aged 20 years
and older by race/ethnicity, National Health and Nutrition Examination Survey, 2003-2004.
Error bars represent 95% confidence intervals. The y-axis is displayed on the logarithmic scale.
Saturated (SFA)
Monounsaturated (MUFA)
Polyunsaturated (PUFA)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
197
197
A.
180
60
160
40
140
DHA ( mol/L)
EPA ( mol/L)
50
30
120
100
80
60
20
40
10
0
20
0
Mexican American
Non-Hispanic black
Non-Hispanic white
Mexican American
Non-Hispanic black
Non-Hispanic white
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198
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2nd Nat
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Indicatorss of Diet and Nutrit
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U.S. P
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2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
199
199
200
200
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
126
85.8
123
120
117
110
126
121
119
(110 144)
(78.9 93.3)
(116 131)
(112 129)
(111 124)
(104 117)
(117 136)
(112 131)
(113 125)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
41.6
32.8
45.6
40.6
44.6
39.0
46.2
44.5
42.5
(39.1 47.5)
(27.9 38.3)
(38.4 47.8)
(34.0 45.1)
(39.5 45.9)
(31.1 42.5)
(41.4 47.9)
(37.9 47.5)
(39.9 45.1)
48.5
39.8
50.9
47.6
48.3
45.0
51.8
50.2
48.1
(40.6 52.3)
(30.2 43.5)
(46.5 55.8)
(44.8 52.6)
(45.9 50.8)
(42.5 46.8)
(47.2 56.4)
(46.3 54.5)
(46.2 50.5)
116
(108 123)
308
(282 353)
392
(360 438)
124
84.3
119
118
115
106
120
120
(108 144)
(72.0 95.0)
(110 127)
(105 129)
(107 121)
(99.0 118)
(109 132)
(112 127)
342
223
310
320
303
301
329
300
(304 470)
(178 283)
(286 364)
(285 384)
(258 359)
(252 370)
(287 401)
(243 366)
408
261
396
414
365
370
410
329
(349 1,810)
(229 410)
(358 464)
(366 508)
(325 434)
(330 533)
(383 481)
(307 426)
375
309
982
856
940
603
514
679
1,796
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
50
100
150
Females
Males
200
Overall
2039
60+
2039
60+
NonHispanic Whites
50
100
150
200
NonHispanic Blacks
4059
4059
2039
60+
2039
200
Females
4059
60+
Males
50
100
150
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
201
201
119
110
126
121
(113 125)
(104 117)
(117 136)
(112 131)
57.9
52.8
61.8
61.4
(55.2 61.1)
(49.4 55.9)
(56.1 66.0)
(54.6 67.0)
116
106
120
120
(108 123)
(99.0 118)
(109 132)
(112 127)
248
240
266
238
(237 266)
(209 260)
(248 294)
(224 256)
1,796
603
514
679
120
112
133
115
(112 129)
(102 122)
(120 147)
(106 126)
58.8
53.4
61.8
58.2
(54.7 61.5)
(47.6 57.8)
(57.5 70.6)
(47.3 67.9)
118
106
124
119
(105 129)
(93.5 122)
(109 154)
(112 123)
260
245
279
226
(243 272)
(209 284)
(265 336)
(201 244)
856
277
247
332
117
109
120
126
(111 124)
(101 117)
(111 131)
(114 139)
56.6
51.3
61.5
64.1
(53.6 61.5)
(49.2 55.4)
(51.6 64.9)
(51.0 73.7)
115
106
115
121
(107 121)
(95.9 119)
(107 123)
(109 143)
242
226
249
244
(225 270)
(193 308)
(226 301)
(227 302)
940
326
267
347
Males
Females
126
122
133
135
(110 144)
(95.1 155)
(112 159)
(124 146)
54.6
51.0
61.2
68.0
(49.2 62.0)
(45.4 56.1)
(46.5 76.0)
(64.2 75.1)
124
123
130
133
(108 144)
(83.9 158)
(95.3 155)
(112 160)
277
259
313
252
(244 352)
(212 1,990)
(248 387)
(224 315)
375
132
93
150
126
123
136
117
(102 156)
(86.4 175)
(104 179)
(104 131)
56.3
51.8
68.5
65.6
(49.6 62.4)
(46.6 57.2)
(54.1 82.7)
(48.2 71.4)
123
123
125
117
(95.9 153)
(67.8 214)
(90.5 177)
(104 135)
282
274
305
199
(228 410)
(202 556)
(201 721)
(164 390)
188
67
48
73
126
119
130
154
(110 145)
(92.9 153)
(99.5 169)
(131 180)
51.4
50.5
50.0
81.6
(40.7 65.3)
(39.7 66.1)
(36.9 74.6)
(54.5 95.1)
127
121
134
153
(108 152)
(93.6 150)
(83.1 193)
(120 195)
268
245
313
274
(240 339)
(173 2,410)
(248 460)
(228 391)
187
65
45
77
Males
Females
202
202
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
85.8
81.9
91.9
84.9
(78.9 93.3)
(72.7 92.2)
(82.8 102)
(76.3 94.5)
44.8
43.6
44.5
46.9
(38.0 50.1)
(33.7 48.1)
(28.4 51.6)
(36.2 58.7)
84.3
76.7
93.4
79.7
(72.0 95.0)
(66.9 92.1)
(82.5 106)
(71.8 95.2)
161
149
184
154
(146 201)
(128 249)
(150 249)
(129 188)
309
125
98
86
87.3
82.7
98.8
78.0
(76.6 99.4)
(67.7 101)
(78.8 124)
(64.2 94.6)
40.9
39.7
41.2
43.7
(31.8 46.6)
(28.5 47.0)
(29.2 55.7)
(36.0 52.8)
85.3
71.6
97.8
67.4
(67.2 98.7)
(61.5 101)
(84.0 115)
(58.9 104)
170
167
229
143
(148 270)
(128 466)
(148 479)
(121 187)
142
57
42
43
84.7
81.2
87.0
89.6
(76.2 94.2)
(72.4 91.2)
(72.2 105)
(78.3 103)
46.5
44.2
46.6
53.5
(39.2 51.8)
(33.9 51.5)
(27.8 51.5)
(39.8 63.8)
83.0
78.8
86.5
82.6
(69.2 99.1)
(64.6 98.7)
(64.8 106)
(73.5 103)
153
144
160
158
(135 189)
(110 259)
(123 690)
(120 194)
167
68
56
43
Males
Females
123
118
127
124
(116 131)
(110 126)
(115 140)
(114 136)
61.6
56.9
63.8
61.8
(56.2 65.5)
(50.1 64.0)
(56.4 69.1)
(53.5 70.8)
119
115
120
121
(110 127)
(103 123)
(108 136)
(116 134)
250
244
266
241
(236 280)
(216 303)
(238 299)
(225 301)
982
294
279
409
126
119
134
120
(115 137)
(107 133)
(120 151)
(108 134)
61.5
58.3
65.6
58.8
(56.0 67.2)
(35.4 67.0)
(57.8 72.3)
(46.7 72.3)
121
115
124
121
(107 141)
(98.2 140)
(108 163)
(115 127)
263
245
272
229
(243 273)
(206 337)
(264 317)
(203 262)
465
124
139
202
121
116
121
128
(114 128)
(104 129)
(108 135)
(114 145)
61.5
55.5
62.2
64.1
(55.6 64.2)
(48.9 63.3)
(48.3 69.0)
(47.6 74.7)
118
114
115
124
(110 123)
(97.3 128)
(104 123)
(110 146)
247
240
237
248
(223 303)
(197 361)
(195 399)
(229 314)
517
170
140
207
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
203
203
204
204
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2,880
2,450
2,720
2,700
2,720
2,540
2,780
2,890
2,710
(2,710 3,050)
(2,340 2,570)
(2,630 2,810)
(2,590 2,810)
(2,640 2,800)
(2,470 2,610)
(2,680 2,880)
(2,790 2,990)
(2,640 2,780)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
1,500
1,540
1,570
1,560
1,570
1,440
1,600
1,750
1,570
(1,310 1,710)
(1,250 1,580)
(1,380 1,610)
(1,380 1,650)
(1,400 1,610)
(1,330 1,550)
(1,330 1,750)
(1,610 1,860)
(1,420 1,610)
1,750
1,590
1,690
1,670
1,710
1,590
1,830
1,910
1,690
(1,500 1,830)
(1,320 1,730)
(1,600 1,780)
(1,570 1,790)
(1,660 1,780)
(1,480 1,670)
(1,650 1,910)
(1,760 1,970)
(1,610 1,770)
2,630
(2,540 2,730)
4,710
(4,500 5,030)
5,370
(5,180 5,630)
2,750
2,330
2,650
2,610
2,640
2,450
2,650
2,820
(2,620 2,970)
(2,240 2,480)
(2,550 2,730)
(2,500 2,710)
(2,540 2,760)
(2,380 2,540)
(2,530 2,800)
(2,740 2,940)
5,430
4,020
4,720
4,730
4,660
4,550
4,750
4,630
(4,580 6,310)
(3,610 4,510)
(4,430 5,270)
(4,400 5,320)
(4,450 5,270)
(4,000 5,330)
(4,560 5,320)
(4,390 5,160)
5,980
4,570
5,350
5,630
5,350
5,340
5,410
5,220
(5,640 6,380)
(4,050 8,480)
(4,930 5,640)
(5,090 6,090)
(4,970 5,500)
(4,740 6,860)
(5,260 5,760)
(4,830 5,790)
374
310
991
863
942
609
514
682
1,805
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
1000
2000
3000
Females
Males
4000
Overall
2039
60+
2039
60+
NonHispanic Whites
1000
2000
3000
4000
NonHispanic Blacks
4059
4059
2039
60+
2039
4000
Females
4059
60+
Males
1000
2000
3000
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
205
205
2,710
2,540
2,780
2,890
(2,640 2,780)
(2,470 2,610)
(2,680 2,880)
(2,790 2,990)
1,890
1,750
1,950
2,050
(1,820 1,930)
(1,660 1,810)
(1,910 1,990)
(1,960 2,140)
2,630
2,450
2,650
2,820
(2,540 2,730)
(2,380 2,540)
(2,530 2,800)
(2,740 2,940)
3,990
3,790
4,160
4,050
(3,820 4,360)
(3,540 4,260)
(3,840 4,570)
(3,840 4,430)
1,805
609
514
682
2,700
2,540
2,840
2,750
(2,590 2,810)
(2,400 2,690)
(2,690 3,000)
(2,640 2,860)
1,880
1,740
1,950
1,960
(1,760 1,920)
(1,580 1,820)
(1,890 2,010)
(1,820 2,070)
2,610
2,470
2,700
2,730
(2,500 2,710)
(2,340 2,600)
(2,480 2,870)
(2,620 2,830)
4,010
3,690
4,420
3,790
(3,790 4,430)
(3,420 4,540)
(4,030 4,760)
(3,530 4,380)
863
282
247
334
2,720
2,530
2,730
3,010
(2,640 2,800)
(2,440 2,640)
(2,620 2,840)
(2,870 3,150)
1,920
1,760
1,960
2,180
(1,820 1,970)
(1,670 1,840)
(1,820 2,090)
(2,050 2,230)
2,640
2,440
2,590
2,950
(2,540 2,760)
(2,350 2,580)
(2,530 2,760)
(2,760 3,150)
3,960
3,870
3,850
4,340
(3,810 4,370)
(3,510 4,530)
(3,620 4,630)
(4,000 4,570)
942
327
267
348
Males
Females
2,880
2,730
3,090
3,140
(2,710 3,050)
(2,510 2,970)
(2,820 3,380)
(3,010 3,280)
1,900
1,820
2,000
2,250
(1,720 2,050)
(1,390 1,970)
(1,480 2,330)
(1,970 2,420)
2,750
2,700
2,840
3,150
(2,620 2,970)
(2,350 2,890)
(2,610 3,290)
(3,010 3,300)
4,540
4,410
4,940
4,530
(4,130 5,550)
(3,700 5,680)
(4,130 6,470)
(3,910 5,350)
374
131
93
150
2,850
2,730
3,110
2,910
(2,580 3,160)
(2,320 3,220)
(2,670 3,630)
(2,740 3,080)
1,890
1,770
1,950
2,090
(1,570 2,010)
(1,460 1,940)
(1,790 2,530)
(1,500 2,420)
2,690
2,540
2,830
2,900
(2,510 3,180)
(2,090 3,270)
(2,580 3,400)
(2,580 3,230)
4,500
4,400
4,580
3,810
(4,020 5,950)
(3,600 6,350)
(3,880 7,970)
(3,500 5,010)
188
67
48
73
2,900
2,730
3,060
3,370
(2,660 3,170)
(2,430 3,070)
(2,650 3,530)
(3,050 3,740)
1,930
1,840
2,050
2,370
(1,330 2,180)
(1,300 2,150)
(1,480 2,330)
(2,060 2,540)
2,790
2,740
2,890
3,370
(2,450 3,280)
(2,230 3,080)
(2,460 3,500)
(2,780 3,790)
4,570
4,330
4,950
5,020
(4,060 5,360)
(3,560 6,760)
(3,540 6,010)
(4,210 6,170)
186
64
45
77
Males
Females
206
206
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2,450
2,350
2,520
2,620
(2,340 2,570)
(2,170 2,530)
(2,370 2,680)
(2,490 2,760)
1,750
1,680
1,790
2,030
(1,600 1,830)
(1,410 1,810)
(1,620 1,890)
(1,870 2,180)
2,330
2,190
2,350
2,510
(2,240 2,480)
(2,070 2,480)
(2,270 2,590)
(2,430 2,760)
3,430
3,390
3,430
3,450
(3,330 3,630)
(3,140 3,730)
(3,370 4,090)
(3,280 3,770)
310
126
98
86
2,450
2,320
2,620
2,520
(2,280 2,640)
(2,080 2,600)
(2,330 2,940)
(2,260 2,820)
1,690
1,570
1,770
1,740
(1,550 1,810)
(1,310 1,770)
(1,380 1,950)
(1,640 1,910)
2,340
2,140
2,370
2,440
(2,180 2,500)
(1,930 2,710)
(2,290 2,620)
(2,150 2,980)
3,550
3,410
4,060
3,290
(3,170 4,270)
(2,940 9,940)
(2,900 8,390)
(3,000 4,330)
143
58
42
43
2,450
2,370
2,450
2,690
(2,300 2,620)
(2,170 2,580)
(2,230 2,680)
(2,520 2,870)
1,800
1,700
1,780
2,180
(1,690 1,870)
(1,390 1,850)
(1,260 1,940)
(1,950 2,240)
2,330
2,230
2,330
2,530
(2,230 2,570)
(2,030 2,590)
(2,140 2,650)
(2,400 2,790)
3,380
3,350
3,370
3,510
(3,210 3,680)
(3,110 4,210)
(2,930 6,230)
(3,260 4,220)
167
68
56
43
Males
Females
2,720
2,550
2,750
2,910
(2,630 2,810)
(2,450 2,640)
(2,630 2,870)
(2,790 3,030)
1,900
1,720
1,950
2,040
(1,800 1,950)
(1,600 1,810)
(1,900 1,990)
(1,950 2,140)
2,650
2,450
2,640
2,840
(2,550 2,730)
(2,370 2,590)
(2,500 2,800)
(2,730 2,990)
3,960
3,790
4,040
4,150
(3,810 4,420)
(3,510 4,490)
(3,790 4,700)
(3,840 4,520)
991
300
279
412
2,700
2,530
2,810
2,780
(2,580 2,840)
(2,360 2,720)
(2,630 2,990)
(2,640 2,920)
1,890
1,680
1,950
1,950
(1,750 1,940)
(1,540 1,800)
(1,890 2,010)
(1,760 2,070)
2,630
2,460
2,700
2,750
(2,500 2,740)
(2,350 2,620)
(2,460 2,930)
(2,600 2,930)
3,960
3,630
4,280
3,830
(3,770 4,500)
(3,260 5,810)
(3,850 4,740)
(3,530 4,690)
471
128
139
204
2,730
2,560
2,690
3,020
(2,640 2,820)
(2,410 2,710)
(2,570 2,830)
(2,860 3,200)
1,920
1,740
1,940
2,140
(1,810 1,970)
(1,600 1,870)
(1,720 2,110)
(2,010 2,250)
2,650
2,440
2,580
2,960
(2,550 2,770)
(2,280 2,690)
(2,530 2,710)
(2,750 3,210)
3,970
3,890
3,780
4,440
(3,810 4,500)
(3,490 4,960)
(3,510 4,690)
(4,030 4,660)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
207
207
208
208
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
710
676
692
690
694
649
718
724
692
(677 745)
(655 697)
(676 709)
(671 710)
(677 712)
(635 664)
(698 738)
(703 746)
(678 706)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
440
440
421
433
421
420
430
471
432
(411 467)
(356 471)
(408 441)
(408 469)
(399 441)
(362 437)
(383 473)
(430 489)
(411 444)
475
473
465
472
462
444
481
511
471
(434 492)
(435 495)
(430 485)
(440 483)
(433 489)
(422 468)
(426 524)
(473 534)
(440 484)
684
(663 705)
1,040
(1,020 1,100)
1,180
(1,130 1,270)
710
669
686
673
689
638
711
731
(666 748)
(645 693)
(663 709)
(644 711)
(667 712)
(624 659)
(682 733)
(697 763)
1,150
961
1,040
1,090
1,030
998
1,100
1,030
(1,030 1,320)
(901 1,130)
(1,020 1,090)
(1,030 1,200)
(975 1,080)
(922 1,120)
(1,040 1,160)
(976 1,120)
1,210
1,130
1,170
1,280
1,140
1,150
1,210
1,130
(1,170 1,330)
(998 2,010)
(1,090 1,270)
(1,170 1,360)
(1,080 1,190)
(1,030 1,470)
(1,130 1,350)
(1,040 1,310)
374
310
992
864
942
609
515
682
1,806
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
500
Females
Males
1000
Overall
2039
60+
2039
60+
NonHispanic Whites
500
1000
NonHispanic Blacks
4059
4059
2039
60+
2039
1000
Females
4059
60+
Males
500
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
209
209
692
649
718
724
(678 706)
(635 664)
(698 738)
(703 746)
515
484
545
552
(489 531)
(468 498)
(520 557)
(538 567)
684
638
711
731
(663 705)
(624 659)
(682 733)
(697 763)
939
870
989
930
(914 963)
(831 932)
(955 1,030)
(893 976)
1,806
609
515
682
690
660
728
679
(671 710)
(636 686)
(697 761)
(656 703)
509
484
548
514
(483 527)
(469 504)
(520 571)
(472 546)
673
643
711
679
(644 711)
(615 672)
(646 752)
(659 718)
967
888
1,020
874
(930 1,010)
(831 1,010)
(997 1,040)
(825 960)
864
282
248
334
694
639
709
763
(677 712)
(620 658)
(685 733)
(736 790)
522
483
532
617
(484 543)
(454 504)
(478 566)
(573 628)
689
635
710
763
(667 712)
(622 658)
(687 733)
(735 786)
916
849
934
971
(892 951)
(817 919)
(900 990)
(914 1,020)
942
327
267
348
Males
Females
710
678
756
776
(677 745)
(632 727)
(710 806)
(735 820)
503
492
534
602
(485 528)
(464 510)
(457 587)
(491 646)
710
664
746
767
(666 748)
(594 755)
(714 770)
(720 815)
997
971
1,060
1,060
(921 1,160)
(801 1,330)
(915 1,470)
(961 1,180)
374
131
93
150
705
682
753
726
(651 764)
(596 779)
(675 841)
(678 776)
501
492
529
593
(480 522)
(456 508)
(469 595)
(457 610)
690
647
725
720
(611 766)
(540 805)
(656 815)
(658 783)
1,030
1,040
1,010
896
(919 1,210)
(830 1,330)
(911 1,490)
(832 1,300)
188
67
48
73
716
673
759
826
(677 758)
(620 732)
(696 828)
(760 897)
514
481
519
624
(443 559)
(340 555)
(439 624)
(541 652)
730
678
756
810
(669 777)
(629 751)
(700 819)
(736 903)
996
835
1,070
1,100
(885 1,140)
(791 1,140)
(859 1,410)
(1,050 1,250)
186
64
45
77
Males
Females
210
210
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
676
645
706
705
(655 697)
(610 682)
(675 738)
(681 729)
509
483
542
561
(458 540)
(435 514)
(477 567)
(511 615)
669
641
693
711
(645 693)
(587 672)
(664 710)
(692 753)
886
887
908
834
(835 941)
(808 945)
(833 1,120)
(806 886)
310
126
98
86
678
651
726
662
(645 713)
(602 704)
(665 792)
(608 720)
483
461
544
503
(455 524)
(422 517)
(475 557)
(334 555)
663
619
676
673
(618 696)
(569 687)
(621 738)
(615 738)
925
897
1,010
830
(854 1,110)
(803 2,540)
(877 1,670)
(782 974)
143
58
42
43
674
639
691
733
(649 699)
(604 677)
(651 733)
(710 757)
514
496
526
638
(354 567)
(446 515)
(353 589)
(558 668)
674
645
693
718
(644 702)
(594 667)
(643 710)
(696 779)
834
833
826
842
(789 1,030)
(715 1,090)
(774 2,490)
(800 885)
167
68
56
43
Males
Females
692
648
710
726
(676 709)
(627 669)
(689 733)
(700 753)
515
481
540
546
(484 533)
(441 507)
(494 565)
(524 566)
686
635
705
733
(663 709)
(614 661)
(675 727)
(695 770)
940
853
969
940
(913 973)
(823 953)
(946 1,020)
(900 1,020)
992
300
280
412
691
662
723
681
(669 715)
(629 696)
(691 757)
(653 711)
512
484
558
508
(480 533)
(433 513)
(513 576)
(471 545)
678
654
709
687
(644 720)
(615 675)
(640 749)
(652 726)
959
844
1,020
880
(919 1,010)
(810 1,250)
(975 1,040)
(819 1,030)
472
128
140
204
693
636
698
766
(673 713)
(607 666)
(672 725)
(733 801)
516
460
519
611
(481 537)
(427 510)
(441 554)
(543 630)
689
627
699
767
(664 713)
(608 658)
(675 730)
(735 801)
923
874
934
981
(899 954)
(818 1,000)
(902 966)
(911 1,050)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
211
211
212
212
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
22.5
23.2
23.6
22.3
24.5
22.2
23.9
24.8
23.4
(21.3 23.8)
(22.1 24.3)
(23.0 24.2)
(21.8 22.8)
(23.9 25.1)
(21.6 22.9)
(23.3 24.5)
(24.1 25.4)
(23.0 23.9)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
13.5
14.6
15.3
14.4
15.9
14.8
15.4
15.6
15.1
(11.4 15.6)
(9.41 15.3)
(14.1 15.8)
(12.7 15.2)
(15.0 16.5)
(13.3 15.2)
(14.4 16.3)
(13.7 16.3)
(14.4 15.5)
15.6
15.4
16.3
15.5
16.9
15.6
16.8
16.7
16.2
(12.7 16.8)
(13.6 16.7)
(15.3 16.8)
(14.5 16.3)
(16.1 17.7)
(15.0 16.2)
(15.6 17.5)
(15.6 18.0)
(15.4 16.7)
23.2
(22.9 23.6)
33.6
(32.5 35.9)
36.7
(35.0 39.1)
22.4
22.7
23.5
22.0
24.3
22.1
23.5
24.9
(21.1 23.7)
(21.9 23.5)
(22.9 24.0)
(21.7 22.3)
(23.7 25.1)
(21.4 23.0)
(22.9 24.2)
(23.8 25.7)
32.7
33.4
34.1
32.0
35.7
31.6
34.0
36.1
(31.2 35.5)
(31.2 40.8)
(32.6 36.9)
(31.4 32.8)
(33.6 38.4)
(30.3 34.0)
(32.4 36.8)
(33.8 38.6)
35.1
35.9
37.5
33.8
38.5
33.9
36.9
38.6
(33.2 41.0)
(33.6 76.6)
(35.6 39.5)
(32.5 36.4)
(36.4 42.2)
(32.4 36.6)
(34.2 43.6)
(36.5 42.2)
367
307
962
843
914
592
500
665
1,757
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
10
20
Females
Males
30
Overall
2039
4059
60+
2039
60+
NonHispanic Whites
20
10
0
30
NonHispanic Blacks
4059
2039
4059
60+
2039
60+
Males
10
20
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
30
Females
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
213
213
23.4
22.2
23.9
24.8
(23.0 23.9)
(21.6 22.9)
(23.3 24.5)
(24.1 25.4)
17.6
16.6
18.3
18.5
(16.9 18.1)
(16.0 17.2)
(17.5 18.8)
(18.0 19.1)
23.2
22.1
23.5
24.9
(22.9 23.6)
(21.4 23.0)
(22.9 24.2)
(23.8 25.7)
31.2
29.5
31.4
32.9
(30.4 32.1)
(28.7 30.6)
(30.2 32.9)
(31.9 34.2)
1,757
592
500
665
22.3
21.4
23.1
22.6
(21.8 22.8)
(20.6 22.3)
(22.2 23.9)
(22.1 23.0)
16.8
16.4
17.4
16.8
(16.0 17.5)
(15.2 17.1)
(16.6 18.0)
(15.8 18.1)
22.0
21.0
22.7
22.4
(21.7 22.3)
(20.5 21.8)
(22.0 23.8)
(21.8 23.0)
29.6
28.1
31.1
29.4
(29.0 31.0)
(26.1 31.6)
(29.2 32.1)
(28.9 30.4)
843
275
241
327
24.5
23.1
24.6
26.7
(23.9 25.1)
(22.3 23.9)
(24.1 25.2)
(25.8 27.7)
18.7
16.9
18.9
20.1
(18.0 19.0)
(16.2 18.5)
(18.3 19.3)
(18.8 21.2)
24.3
23.4
24.2
26.9
(23.7 25.1)
(22.6 23.8)
(23.5 25.3)
(25.7 28.1)
32.3
30.1
32.6
35.4
(31.2 33.6)
(29.2 31.2)
(30.7 34.4)
(33.2 38.1)
914
317
259
338
Males
Females
22.5
22.2
23.0
22.7
(21.3 23.8)
(20.8 23.6)
(21.1 25.0)
(21.2 24.4)
16.9
16.5
16.9
17.4
(15.3 18.2)
(12.4 18.3)
(13.9 18.7)
(14.6 18.7)
22.4
21.8
23.0
22.9
(21.1 23.7)
(20.6 23.6)
(21.4 25.2)
(21.8 24.2)
29.6
29.5
30.6
29.3
(27.9 33.1)
(27.1 36.1)
(27.4 41.6)
(27.4 34.1)
367
130
91
146
22.1
21.9
22.4
21.6
(20.6 23.7)
(20.2 23.9)
(19.9 25.3)
(19.5 24.0)
16.8
16.6
15.9
15.8
(9.37 18.3)
(11.7 19.0)
(12.5 19.1)
(9.37 18.7)
22.4
21.7
23.0
21.9
(20.5 23.8)
(19.6 23.9)
(19.4 25.4)
(20.2 24.7)
28.3
27.6
29.3
27.8
(26.9 32.7)
(24.5 36.3)
(26.8 31.9)
(25.5 32.7)
185
66
47
72
23.0
22.5
23.6
23.8
(21.6 24.5)
(20.6 24.5)
(21.6 25.8)
(21.9 25.9)
16.8
16.4
17.3
18.5
(15.9 18.5)
(12.9 18.5)
(15.6 19.2)
(13.1 20.6)
22.5
21.8
22.8
23.9
(21.3 24.0)
(20.2 23.9)
(21.3 25.3)
(22.2 24.5)
31.0
29.7
31.8
30.2
(28.3 43.0)
(27.3 43.7)
(27.5 41.6)
(27.2 40.1)
182
64
44
74
Males
Females
214
214
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
23.2
22.5
24.2
23.2
(22.1 24.3)
(21.3 23.8)
(22.6 25.8)
(21.7 24.7)
17.4
17.0
17.0
18.3
(15.9 18.4)
(13.7 18.5)
(15.3 19.1)
(15.4 18.8)
22.7
22.0
23.5
22.9
(21.9 23.5)
(21.4 22.8)
(22.5 25.2)
(21.1 25.6)
31.0
30.5
31.9
29.5
(29.3 33.1)
(28.0 34.0)
(29.4 35.9)
(28.3 35.6)
307
124
98
85
22.4
21.4
24.3
21.6
(21.2 23.7)
(19.2 23.9)
(21.7 27.1)
(20.2 23.1)
15.9
14.9
16.1
15.5
(11.7 18.2)
(11.3 18.3)
(14.7 19.7)
(8.59 18.4)
21.5
20.7
23.1
21.2
(20.7 22.8)
(18.6 22.4)
(21.3 26.5)
(20.3 24.1)
31.2
31.2
31.7
27.9
(29.0 35.8)
(23.2 71.3)
(29.4 48.6)
(25.6 33.8)
142
57
42
43
23.8
23.4
24.1
24.2
(22.6 25.1)
(22.0 25.0)
(22.7 25.6)
(21.5 27.1)
18.4
18.7
17.0
18.6
(16.2 19.9)
(14.9 20.5)
(14.8 20.5)
(14.3 20.6)
23.4
22.8
23.6
23.9
(22.2 25.1)
(21.9 25.3)
(21.8 25.8)
(19.8 29.5)
30.3
29.5
31.8
29.9
(28.7 34.8)
(27.8 32.5)
(27.7 54.9)
(29.3 37.1)
165
67
56
42
Males
Females
23.6
22.2
23.8
25.2
(23.0 24.2)
(21.3 23.1)
(23.1 24.6)
(24.6 25.9)
17.6
16.5
18.4
19.0
(16.7 18.4)
(15.4 17.0)
(17.4 19.3)
(18.0 19.4)
23.5
22.0
23.4
25.3
(22.9 24.0)
(20.9 23.5)
(22.9 24.1)
(24.4 26.4)
31.6
29.6
31.5
33.5
(30.6 32.6)
(28.3 31.3)
(29.9 34.3)
(32.2 35.6)
962
290
270
402
22.4
21.2
23.0
22.9
(21.7 23.0)
(20.1 22.4)
(21.9 24.2)
(22.3 23.5)
16.7
16.3
17.6
16.9
(16.1 17.6)
(13.6 17.0)
(15.6 18.6)
(16.1 18.3)
22.0
20.8
22.5
22.8
(21.7 22.4)
(19.9 22.0)
(21.9 23.8)
(22.1 23.5)
29.8
28.5
31.1
29.6
(29.0 31.2)
(25.8 32.1)
(28.9 32.4)
(29.0 31.6)
460
125
136
199
24.8
23.0
24.7
27.4
(24.0 25.7)
(21.9 24.3)
(24.0 25.5)
(26.4 28.4)
18.7
16.7
18.9
20.9
(17.7 19.1)
(15.9 17.7)
(18.2 19.7)
(19.1 21.7)
24.8
23.6
24.2
27.6
(23.8 25.7)
(22.3 24.4)
(23.3 25.5)
(26.5 28.8)
32.9
30.1
32.7
36.0
(31.4 35.6)
(29.3 31.3)
(30.5 37.1)
(33.6 38.6)
502
165
134
203
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
215
215
216
216
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(65.1 67.9)
(68.5 75.2)
(68.2 72.4)
(64.0 67.7)
(70.4 75.2)
(61.3 67.7)
(66.5 73.0)
(68.9 72.0)
65.8
72.8
64.4
69.6
70.4
(67.7 71.0)
66.5
71.8
70.2
69.3
Non-Hispanic Whites
Non-Hispanic Blacks
Mexican Americans
Race/ethnicity
Males
Females
Gender
4059 years
60 years and older
2039 years
39.0
41.1
42.6
39.3
43.4
42.6
41.6
39.2
41.5
(35.4 41.8)
(20.8 47.2)
(39.4 43.7)
(34.2 42.4)
(40.5 47.0)
(38.0 44.3)
(20.1 45.2)
(31.7 42.9)
(38.1 43.2)
42.0
46.3
46.9
43.0
48.4
46.1
46.4
43.0
45.2
(37.4 46.5)
(34.5 51.1)
(43.4 48.5)
(39.7 45.1)
(45.1 50.3)
(43.0 48.1)
(40.2 49.5)
(40.1 46.2)
(42.9 47.6)
64.4
69.4
70.9
66.2
73.7
66.5
74.0
70.9
69.5
(60.9 67.4)
(64.3 74.7)
(69.4 72.8)
(64.2 68.3)
(70.7 75.6)
(65.0 68.5)
(68.3 76.6)
(68.1 73.4)
(68.0 71.4)
95.3
106
104
96.4
106
97.4
105
109
102
(87.1 129)
(104 107)
(99.2 110)
(94.9 98.2)
(102 111)
(94.4 98.7)
(99.0 111)
(105 114)
(99.0 108)
97.9
115
111
105
113
99.9
111
115
110
(94.9 129)
(107 123)
(108 121)
(98.2 111)
(108 128)
(98.3 104)
(106 134)
(111 128)
(106 117)
367
306
947
834
905
589
496
654
1,739
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Selected percentiles (95% conf. interval)
Sample
Geometric mean
2.5th
5th
50th
95th
97.5th
size
( 95% conf. interval)
80
20
40
60
Females
Males
2039
60+
2039
60+
NonHispanic Whites
20
40
60
80
100
4059
4059
NonHispanic Blacks
2039
4059
60+
2039
60+
Males
80
100
Females
4059
20
40
60
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Mexican Americans
100
Overall
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
217
217
69.3
66.5
71.8
70.2
(67.7 71.0)
(65.1 67.9)
(68.5 75.2)
(68.2 72.4)
50.1
49.7
51.9
49.1
(48.7 51.5)
(48.9 51.0)
(47.5 55.9)
(46.2 50.7)
69.5
66.5
74.0
70.9
(68.0 71.4)
(65.0 68.5)
(68.3 76.6)
(68.1 73.4)
95.3
89.5
96.4
100
(93.0 97.7)
(86.7 93.6)
(93.8 100)
(96.1 105)
1,739
589
496
654
65.8
64.7
68.7
63.1
(64.0 67.7)
(62.6 66.8)
(65.3 72.2)
(60.8 65.5)
48.1
49.3
48.3
43.6
(45.1 49.7)
(46.8 51.2)
(43.0 51.4)
(40.8 47.0)
66.2
63.7
70.9
64.3
(64.2 68.3)
(61.0 66.2)
(66.0 74.5)
(60.6 67.9)
90.5
88.7
92.2
88.2
(88.2 92.5)
(82.6 93.6)
(89.0 96.9)
(85.2 91.7)
834
274
238
322
72.8
68.3
74.9
76.6
(70.4 75.2)
(66.2 70.6)
(70.9 79.1)
(73.8 79.6)
52.4
50.9
56.6
54.1
(50.4 55.1)
(48.4 51.7)
(48.1 58.3)
(49.1 58.5)
73.7
69.4
76.5
75.7
(70.7 75.6)
(66.8 71.6)
(70.1 80.6)
(73.2 80.1)
98.7
91.4
99.0
107
(96.1 102)
(86.0 97.4)
(94.7 108)
(103 112)
905
315
258
332
Males
Females
64.4
64.0
66.5
61.4
(61.3 67.7)
(60.8 67.4)
(61.6 71.8)
(56.4 66.9)
47.8
48.4
48.1
42.7
(41.7 51.6)
(42.0 50.6)
(35.5 55.5)
(38.6 47.2)
64.4
63.1
67.7
61.4
(60.9 67.4)
(59.7 66.8)
(64.3 71.7)
(59.8 64.2)
87.1
85.7
87.9
85.0
(81.5 95.4)
(80.1 95.4)
(80.6 106)
(74.6 120)
367
129
91
147
64.0
65.2
63.1
59.6
(60.5 67.7)
(62.2 68.3)
(56.3 70.6)
(53.5 66.3)
48.2
49.6
44.8
38.8
(38.9 52.7)
(31.7 55.2)
(35.5 55.6)
(35.0 43.0)
64.4
63.8
65.0
61.3
(60.8 67.1)
(60.7 66.9)
(55.7 72.0)
(55.7 65.1)
85.2
86.8
81.4
87.6
(80.7 90.4)
(77.5 116)
(74.8 97.7)
(68.0 112)
185
65
47
73
64.9
62.5
70.7
63.1
(60.6 69.6)
(57.1 68.4)
(65.1 76.6)
(56.5 70.6)
46.5
42.2
53.4
47.0
(41.2 50.7)
(38.2 50.3)
(37.4 57.1)
(34.0 54.2)
64.5
61.3
68.7
62.0
(59.9 71.3)
(55.1 70.9)
(65.7 76.7)
(57.9 66.5)
92.9
83.6
93.5
82.9
(79.5 120)
(76.3 97.3)
(85.0 106)
(75.2 116)
182
64
44
74
Males
Females
218
218
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
69.6
67.3
75.2
65.6
(66.5 73.0)
(63.9 70.8)
(70.9 79.7)
(61.9 69.5)
52.1
52.3
53.1
47.9
(46.8 53.9)
(42.4 54.1)
(42.9 59.2)
(27.8 53.2)
69.4
65.0
78.6
65.4
(64.3 74.7)
(62.8 71.2)
(71.7 82.9)
(61.9 68.1)
94.2
89.8
104
91.3
(91.4 101)
(86.7 97.6)
(91.6 118)
(81.1 118)
306
124
98
84
66.1
63.5
73.0
59.6
(62.1 70.3)
(58.3 69.1)
(64.3 83.0)
(54.0 65.7)
47.6
49.2
44.8
41.2
(33.1 53.2)
(34.5 53.7)
(39.5 59.2)
(20.8 47.8)
64.6
61.5
74.5
60.2
(61.6 68.4)
(57.0 66.1)
(62.0 85.4)
(53.4 67.0)
90.2
86.6
93.5
81.3
(87.9 98.0)
(76.7 119)
(86.7 171)
(73.0 95.8)
141
57
42
42
72.5
70.6
76.8
69.7
(69.2 76.0)
(65.5 76.0)
(72.5 81.4)
(62.7 77.4)
53.8
53.0
55.8
53.1
(50.3 56.1)
(40.9 57.0)
(43.3 61.0)
(41.5 55.8)
73.9
71.3
80.4
67.8
(66.3 78.4)
(63.1 79.9)
(72.4 84.5)
(59.0 76.7)
99.7
91.5
105
100
(91.4 106)
(88.3 96.2)
(91.6 117)
(79.0 123)
165
67
56
42
Males
Females
70.4
67.1
72.3
72.3
(68.9 72.0)
(65.4 68.8)
(68.7 76.0)
(70.5 74.1)
50.8
49.9
52.1
50.1
(49.4 51.7)
(48.6 51.2)
(48.5 56.3)
(47.1 53.0)
70.9
68.1
74.3
72.5
(69.4 72.8)
(65.9 69.5)
(68.3 76.9)
(70.4 74.6)
96.4
90.6
96.5
102
(94.6 98.5)
(85.6 96.6)
(93.4 103)
(98.0 108)
947
288
267
392
66.9
65.3
69.6
64.6
(64.8 69.0)
(62.5 68.2)
(66.0 73.4)
(61.6 67.7)
49.2
49.5
49.9
46.9
(46.5 51.0)
(44.6 51.7)
(41.9 55.0)
(43.1 49.4)
67.8
64.4
72.3
65.3
(65.4 69.6)
(61.8 68.6)
(66.0 75.2)
(62.4 69.7)
92.0
89.1
93.1
88.4
(88.7 94.5)
(80.8 97.3)
(90.8 96.8)
(85.6 92.0)
453
125
134
194
73.9
68.8
75.0
79.5
(71.2 76.8)
(66.0 71.7)
(69.9 80.4)
(77.1 81.9)
52.8
51.0
56.4
57.0
(49.8 56.8)
(47.5 52.1)
(44.8 59.1)
(49.9 62.1)
74.4
69.4
76.5
78.5
(71.7 76.5)
(67.8 72.6)
(67.5 81.7)
(75.6 83.3)
99.3
92.8
98.6
109
(96.1 108)
(85.6 98.1)
(94.6 110)
(105 113)
494
163
133
198
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
219
219
220
220
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
50.4
53.3
54.7
53.7
54.4
51.6
56.4
54.3
54.0
(47.3 53.7)
(50.5 56.2)
(53.4 56.0)
(52.2 55.2)
(52.6 56.2)
(50.3 53.0)
(54.2 58.7)
(52.7 56.0)
(52.8 55.3)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
29.9
30.8
31.5
30.6
32.4
31.8
33.2
29.1
31.2
(19.2 32.6)
(24.0 35.4)
(28.7 33.6)
(28.5 33.0)
(29.8 35.0)
(26.8 35.2)
(28.7 37.6)
(21.7 31.0)
(29.5 33.0)
32.4
34.8
35.8
34.6
35.8
35.6
37.8
31.6
35.3
(28.7 36.0)
(27.0 38.0)
(33.1 37.2)
(30.7 37.7)
(32.6 37.0)
(32.4 36.6)
(32.9 39.6)
(30.0 34.2)
(32.7 36.8)
53.8
(52.6 55.6)
80.9
(79.0 83.6)
87.0
(84.9 90.2)
50.1
53.1
54.8
53.7
53.8
51.3
56.6
54.8
(47.2 53.8)
(49.6 57.0)
(53.0 56.5)
(51.6 55.8)
(52.7 56.1)
(49.8 52.9)
(54.1 59.6)
(52.4 57.5)
76.4
79.0
81.4
80.8
80.7
73.6
81.1
86.9
(71.1 83.0)
(73.3 84.2)
(79.1 85.0)
(76.4 84.9)
(78.7 84.5)
(71.8 78.6)
(77.4 88.0)
(81.9 91.9)
80.7
83.9
87.2
86.1
87.3
82.0
86.8
92.3
(76.9 117)
(79.0 112)
(85.1 92.1)
(84.5 93.1)
(83.8 91.9)
(76.0 88.3)
(83.6 94.4)
(89.1 97.5)
355
302
966
836
907
583
495
665
1,743
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
60
20
40
Females
Males
80
Overall
2039
4059
60+
2039
60+
NonHispanic Whites
60
40
20
0
80
NonHispanic Blacks
4059
2039
4059
60+
2039
60+
Males
60
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
80
Females
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
221
221
54.0
51.6
56.4
54.3
(52.8 55.3)
(50.3 53.0)
(54.2 58.7)
(52.7 56.0)
39.0
37.9
41.4
37.1
(37.4 40.6)
(36.6 39.6)
(37.9 43.7)
(33.6 39.5)
53.8
51.3
56.6
54.8
(52.6 55.6)
(49.8 52.9)
(54.1 59.6)
(52.4 57.5)
74.2
69.0
76.0
77.9
(72.2 76.4)
(66.5 71.8)
(72.9 79.2)
(76.4 81.4)
1,743
583
495
665
53.7
53.1
56.3
50.3
(52.2 55.2)
(51.2 55.1)
(53.6 59.0)
(48.3 52.4)
39.1
39.5
41.1
33.6
(37.1 41.0)
(37.9 42.3)
(34.7 44.2)
(30.2 37.8)
53.7
52.1
56.1
50.4
(51.6 55.8)
(50.1 55.5)
(53.5 60.5)
(47.1 55.0)
72.6
70.9
75.1
70.2
(70.8 74.8)
(67.6 74.9)
(71.7 83.1)
(68.5 74.4)
836
272
238
326
54.4
50.1
56.5
57.8
(52.6 56.2)
(48.7 51.6)
(53.9 59.3)
(55.5 60.2)
39.0
36.6
42.2
39.9
(36.5 41.6)
(34.8 37.9)
(39.0 43.6)
(35.3 42.3)
53.8
50.2
57.0
58.5
(52.7 56.1)
(48.9 51.9)
(53.5 60.0)
(55.2 61.3)
76.1
67.3
76.0
82.8
(72.5 78.4)
(64.9 69.6)
(72.2 79.6)
(78.9 89.0)
907
311
257
339
Males
Females
50.4
50.1
52.5
46.7
(47.3 53.7)
(46.5 53.9)
(47.5 58.0)
(41.5 52.7)
37.1
37.1
38.8
33.0
(31.5 39.5)
(30.6 38.8)
(21.0 44.5)
(19.2 36.9)
50.1
49.2
53.3
47.1
(47.2 53.8)
(44.7 56.1)
(47.1 59.6)
(40.1 53.9)
69.4
68.7
71.6
66.4
(66.9 73.7)
(63.7 76.3)
(65.8 81.4)
(58.7 97.3)
355
120
89
146
52.9
54.0
52.7
46.7
(49.2 56.9)
(50.3 58.1)
(45.9 60.5)
(40.9 53.4)
39.3
40.7
36.7
32.2
(33.0 43.1)
(37.8 44.4)
(28.8 45.9)
(19.2 36.7)
52.4
52.3
53.2
48.2
(48.7 56.2)
(48.1 57.7)
(46.0 60.5)
(38.4 54.3)
72.2
69.7
72.4
69.1
(67.8 77.5)
(63.8 84.8)
(65.3 81.2)
(55.8 89.1)
176
61
45
70
47.6
45.3
52.2
46.7
(44.6 50.7)
(41.0 50.0)
(47.3 57.7)
(39.8 54.8)
32.6
32.0
39.2
34.7
(30.3 36.7)
(29.8 36.6)
(21.0 43.4)
(25.4 38.0)
46.5
43.2
53.3
45.3
(43.4 51.0)
(37.9 52.6)
(44.8 60.2)
(39.4 54.7)
67.8
64.6
69.6
63.8
(61.8 71.1)
(57.6 78.7)
(61.1 83.2)
(54.4 97.3)
179
59
44
76
Males
Females
222
222
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
53.3
51.2
57.6
50.9
(50.5 56.2)
(48.2 54.5)
(54.6 60.8)
(46.1 56.2)
38.6
37.2
40.9
37.3
(35.4 40.9)
(29.9 41.6)
(33.9 46.2)
(29.8 40.2)
53.1
49.9
58.1
50.8
(49.6 57.0)
(48.0 55.7)
(54.2 63.3)
(43.5 55.2)
71.8
67.9
73.0
74.1
(70.3 74.3)
(65.1 74.2)
(71.0 85.7)
(63.0 94.8)
302
123
95
84
53.4
51.3
58.6
49.2
(50.0 56.9)
(47.2 55.7)
(52.1 65.9)
(44.5 54.4)
38.8
38.8
40.9
30.6
(27.0 43.3)
(26.2 43.5)
(32.2 48.9)
(24.0 40.9)
52.8
49.9
60.1
49.5
(49.1 58.6)
(46.3 55.9)
(50.6 70.1)
(44.5 54.7)
71.8
66.5
73.8
70.7
(68.1 80.6)
(63.1 83.8)
(70.1 112)
(62.3 79.1)
140
57
41
42
53.2
51.2
56.8
52.0
(50.1 56.6)
(47.7 54.8)
(53.8 60.1)
(45.0 60.1)
38.2
36.8
39.9
39.7
(35.3 40.8)
(28.1 41.1)
(34.9 46.2)
(31.4 40.4)
53.3
49.7
56.6
52.4
(49.2 57.7)
(46.0 57.4)
(51.9 61.3)
(40.8 62.0)
72.0
69.3
72.2
78.2
(69.6 78.2)
(65.3 72.9)
(70.3 85.2)
(62.0 95.2)
162
66
54
42
Males
Females
54.7
51.8
56.7
55.7
(53.4 56.0)
(50.1 53.6)
(54.2 59.3)
(54.1 57.3)
39.6
37.9
42.0
38.2
(37.7 41.6)
(35.9 41.2)
(38.6 43.2)
(33.4 41.0)
54.8
51.5
57.0
56.3
(53.0 56.5)
(49.4 53.9)
(53.6 60.8)
(54.0 58.6)
75.3
68.9
76.4
78.7
(73.0 77.3)
(66.0 72.6)
(72.8 80.8)
(76.9 82.3)
966
293
270
403
54.1
53.2
56.9
51.1
(52.5 55.8)
(50.5 56.0)
(53.9 60.0)
(48.6 53.8)
39.4
39.4
42.1
34.8
(36.1 41.8)
(35.8 42.8)
(35.0 44.7)
(29.7 39.0)
54.7
52.5
57.1
51.4
(51.8 56.5)
(49.5 56.8)
(53.1 61.8)
(47.1 56.4)
72.8
70.5
76.6
70.2
(70.5 77.2)
(66.0 82.9)
(71.7 85.9)
(68.4 75.8)
461
126
135
200
55.2
50.6
56.5
59.9
(53.1 57.4)
(48.5 52.8)
(53.2 59.9)
(57.8 62.0)
39.7
36.7
41.8
40.9
(36.6 42.5)
(32.4 41.2)
(38.2 43.1)
(36.7 44.9)
55.1
51.3
56.9
60.4
(53.0 57.3)
(48.6 53.2)
(53.0 62.0)
(58.3 62.5)
76.6
67.3
76.4
85.4
(74.2 79.2)
(64.8 69.9)
(71.8 81.2)
(79.9 91.5)
505
167
135
203
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
223
223
224
224
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
6.95
3.91
7.07
6.35
6.77
6.21
7.06
6.39
6.57
(5.89 8.20)
(3.50 4.38)
(6.45 7.74)
(5.70 7.07)
(6.26 7.32)
(5.67 6.80)
(6.30 7.90)
(5.61 7.26)
(6.08 7.09)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
1.53
1.06
1.65
1.25
1.59
1.47
1.44
1.40
1.45
(1.02 1.80)
(.703 1.17)
(1.42 1.79)
(1.05 1.39)
(1.46 1.75)
(1.17 1.64)
(1.11 1.69)
(1.17 1.67)
(1.31 1.56)
1.82
1.18
2.06
1.70
1.94
1.76
1.86
1.73
1.79
(1.51 2.05)
(1.06 1.42)
(1.80 2.33)
(1.41 1.82)
(1.71 2.32)
(1.64 2.01)
(1.63 2.02)
(1.56 1.99)
(1.68 1.96)
6.83
3.78
6.84
6.47
6.51
6.05
6.87
6.40
6.50
(5.90 6.99)
23.9
(21.4 29.3)
32.1
(27.0 40.2)
(5.44 8.30)
(3.17 4.49)
(6.22 7.46)
(5.47 7.28)
(5.96 6.96)
(5.34 6.75)
(6.20 7.62)
(5.53 7.45)
26.1
12.8
24.9
24.9
23.4
24.0
25.8
23.3
(21.1 35.6)
(11.5 21.4)
(22.3 31.8)
(22.8 29.7)
(19.9 31.2)
(19.3 32.6)
(21.4 34.6)
(19.3 30.9)
33.1
20.3
32.7
33.0
30.7
31.9
34.6
26.9
(27.4 68.4)
(13.7 31.3)
(27.0 43.6)
(29.4 40.6)
(23.9 48.1)
(24.8 67.0)
(27.0 52.9)
(23.4 40.7)
376
310
992
865
943
610
515
683
1,808
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
10
5
Females
Males
15
Overall
2039
4059
60+
2039
60+
NonHispanic Whites
10
5
0
15
NonHispanic Blacks
4059
2039
4059
60+
2039
60+
Males
10
5
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
15
Females
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
225
225
6.57
6.21
7.06
6.39
(6.08 7.09)
(5.67 6.80)
(6.30 7.90)
(5.61 7.26)
2.41
2.33
2.53
2.43
(2.26 2.59)
(2.08 2.52)
(2.20 2.94)
(2.04 2.89)
6.50
6.05
6.87
6.40
(5.90 6.99)
(5.34 6.75)
(6.20 7.62)
(5.53 7.45)
18.5
16.9
19.6
17.3
(16.7 20.5)
(14.8 20.4)
(18.0 22.2)
(13.1 23.4)
1,808
610
515
683
6.35
6.08
7.02
5.74
(5.70 7.07)
(5.23 7.08)
(6.06 8.12)
(5.08 6.48)
2.20
2.10
2.27
2.26
(2.01 2.35)
(2.03 2.33)
(1.80 2.81)
(1.68 2.61)
6.47
6.09
6.98
5.82
(5.47 7.28)
(5.00 7.32)
(5.49 8.66)
(5.44 6.42)
18.5
16.9
21.0
13.7
(16.5 21.2)
(14.5 23.9)
(18.5 26.2)
(10.9 20.0)
865
282
248
335
6.77
6.34
7.09
6.97
(6.26 7.32)
(5.67 7.08)
(6.37 7.90)
(5.87 8.26)
2.73
2.62
2.87
2.91
(2.52 2.96)
(2.06 2.94)
(2.39 3.40)
(1.76 3.22)
6.51
5.91
6.81
6.89
(5.96 6.96)
(5.31 6.92)
(6.29 7.17)
(5.55 8.06)
18.4
17.2
18.7
20.0
(15.3 21.6)
(13.9 22.4)
(13.8 23.3)
(16.1 23.8)
943
328
267
348
Males
Females
6.95
6.79
7.17
7.30
(5.89 8.20)
(5.03 9.17)
(5.73 8.97)
(6.27 8.49)
2.26
2.11
2.48
3.03
(1.82 2.82)
(1.71 2.75)
(1.66 2.92)
(2.65 3.26)
6.83
6.39
6.96
7.48
(5.44 8.30)
(4.79 9.10)
(5.46 9.72)
(5.22 9.67)
19.4
18.7
20.0
16.7
(17.2 22.5)
(15.2 32.7)
(16.1 32.0)
(14.6 24.9)
376
132
93
151
6.79
6.79
7.08
5.90
(5.24 8.79)
(4.48 10.3)
(4.81 10.4)
(4.57 7.62)
2.27
2.15
2.69
2.72
(1.79 2.93)
(1.85 2.42)
(1.87 3.06)
(1.76 3.30)
6.58
6.56
6.77
5.60
(4.63 8.66)
(3.74 11.8)
(3.71 12.3)
(3.54 8.59)
20.0
20.2
18.8
13.6
(15.8 24.9)
(15.3 42.7)
(14.0 52.0)
(9.90 18.3)
189
67
48
74
7.16
6.78
7.27
8.88
(6.00 8.55)
(4.95 9.30)
(5.08 10.4)
(7.36 10.7)
2.03
1.96
1.93
3.63
(1.53 3.55)
(1.51 3.90)
(1.62 2.55)
(2.33 4.14)
6.86
6.02
7.32
9.24
(5.60 9.13)
(4.64 9.28)
(3.75 13.4)
(7.46 12.9)
18.7
16.3
22.2
17.4
(16.3 23.9)
(12.9 156)
(16.4 30.1)
(14.8 43.2)
187
65
45
77
Males
Females
226
226
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3.91
3.95
4.07
3.51
(3.50 4.38)
(3.33 4.70)
(3.55 4.66)
(3.15 3.92)
1.48
1.68
1.44
1.30
(1.28 1.69)
(1.29 1.90)
(1.07 1.66)
(1.07 1.63)
3.78
3.54
4.21
3.37
(3.17 4.49)
(3.05 4.70)
(2.82 4.90)
(2.94 4.54)
10.4
10.2
11.7
9.13
(8.24 12.7)
(7.80 12.7)
(8.28 21.4)
(7.34 11.4)
310
126
98
86
3.95
3.99
4.30
3.13
(3.24 4.80)
(2.96 5.36)
(3.03 6.10)
(2.27 4.32)
1.23
1.37
1.08
1.30
(1.06 1.46)
(.992 1.92)
(.703 1.28)
(1.16 1.49)
4.23
3.41
4.74
2.53
(2.79 4.93)
(2.61 5.34)
(4.11 6.89)
(1.60 5.17)
11.3
10.7
12.4
8.55
(8.12 21.6)
(7.65 61.3)
(8.22 24.7)
(6.21 14.2)
143
58
42
43
3.89
3.93
3.90
3.78
(3.46 4.37)
(3.38 4.56)
(3.15 4.82)
(3.23 4.42)
1.70
1.77
1.66
1.25
(1.43 2.07)
(1.45 1.94)
(1.44 2.21)
(.999 2.33)
3.60
3.65
3.42
3.54
(3.10 4.46)
(3.11 4.77)
(2.47 4.70)
(3.09 4.69)
8.84
8.32
8.90
9.24
(7.45 12.7)
(6.65 12.6)
(7.34 19.3)
(5.98 19.5)
167
68
56
43
Males
Females
7.07
6.97
7.39
6.72
(6.45 7.74)
(6.26 7.77)
(6.43 8.48)
(5.80 7.78)
2.83
2.79
2.87
2.63
(2.49 3.02)
(2.35 3.08)
(2.24 3.54)
(2.26 3.01)
6.84
6.61
6.97
6.72
(6.22 7.46)
(5.91 7.53)
(6.17 7.94)
(5.74 7.72)
19.5
18.5
19.8
17.9
(16.9 23.0)
(15.1 24.6)
(17.0 26.7)
(13.8 23.5)
992
300
280
412
6.84
6.84
7.31
6.13
(6.01 7.79)
(5.71 8.20)
(6.16 8.67)
(5.25 7.15)
2.47
2.39
2.49
2.43
(2.07 2.86)
(2.03 2.95)
(1.82 2.96)
(1.75 2.89)
6.77
6.53
7.03
6.36
(5.68 7.91)
(5.25 8.27)
(4.70 10.4)
(5.73 6.86)
18.7
17.0
21.0
15.9
(16.9 22.7)
(14.4 31.7)
(18.1 27.6)
(11.0 23.9)
472
128
140
204
7.28
7.09
7.46
7.27
(6.68 7.93)
(5.99 8.39)
(6.48 8.59)
(5.90 8.94)
3.16
2.94
3.56
3.01
(2.81 3.49)
(2.37 3.49)
(2.06 4.04)
(1.59 3.69)
6.86
6.67
6.84
7.09
(6.52 7.22)
(5.66 8.11)
(6.33 7.23)
(5.55 8.67)
19.6
19.0
18.9
20.7
(15.9 23.8)
(14.7 28.0)
(13.4 43.3)
(17.0 25.2)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
227
227
228
228
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
240
157
221
207
226
195
228
238
217
(209 277)
(148 167)
(208 236)
(190 225)
(214 239)
(185 205)
(210 248)
(220 259)
(205 229)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
78.6
64.8
74.9
69.0
83.2
72.5
69.3
84.8
73.3
(60.0 86.2)
(47.2 68.9)
(53.0 83.5)
(53.4 74.7)
(71.2 88.4)
(60.4 78.7)
(45.2 78.1)
(65.4 94.1)
(65.1 78.1)
87.0
70.3
88.9
77.7
93.4
82.0
82.4
100
84.0
(64.2 95.4)
(64.2 73.2)
(79.3 96.5)
(68.8 84.0)
(89.1 104)
(75.0 84.1)
(71.3 96.8)
(87.9 113)
(79.0 89.6)
239
151
221
203
226
185
228
241
213
(196 230)
563
(526 664)
727
(657 806)
(204 281)
(142 162)
(201 237)
(182 225)
(204 243)
(173 194)
(206 251)
(216 263)
692
429
554
562
567
539
572
559
(594 780)
(352 529)
(522 661)
(495 683)
(528 679)
(450 674)
(525 772)
(528 649)
769
523
722
682
729
685
770
676
(699 1,110)
(433 755)
(615 831)
(578 926)
(630 846)
(611 840)
(671 837)
(589 763)
375
310
990
863
942
610
514
681
1,805
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
100
200
300
Females
Males
2039
60+
2039
60+
NonHispanic Whites
100
200
300
400
4059
4059
NonHispanic Blacks
2039
4059
60+
2039
400
Females
4059
60+
Males
100
200
300
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Mexican Americans
400
Overall
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
229
229
217
195
228
238
(205 229)
(185 205)
(210 248)
(220 259)
105
92.3
106
122
(97.7 109)
(86.5 98.3)
(92.9 118)
(111 135)
213
185
228
241
(196 230)
(173 194)
(206 251)
(216 263)
454
411
475
467
(424 497)
(357 472)
(444 549)
(429 540)
1,805
610
514
681
207
192
223
207
(190 225)
(171 215)
(198 251)
(191 224)
92.6
83.9
97.4
112
(84.0 98.9)
(76.9 93.8)
(78.0 108)
(92.6 121)
203
185
218
206
(182 225)
(169 211)
(184 273)
(186 228)
456
410
501
386
(400 525)
(344 542)
(450 594)
(339 450)
863
282
248
333
226
197
233
267
(214 239)
(185 211)
(217 250)
(240 298)
114
108
126
137
(108 123)
(92.2 111)
(99.4 133)
(115 150)
226
184
231
271
(204 243)
(170 199)
(213 256)
(242 297)
453
406
455
537
(421 525)
(352 495)
(395 534)
(493 585)
942
328
266
348
Males
Females
240
223
267
277
(209 277)
(181 274)
(232 307)
(262 292)
101
95.2
117
144
(64.3 131)
(60.0 129)
(79.8 143)
(136 158)
239
221
250
281
(204 281)
(175 274)
(233 272)
(250 308)
571
498
639
510
(498 645)
(386 737)
(545 804)
(446 587)
375
132
93
150
237
225
267
230
(192 292)
(169 300)
(194 367)
(192 276)
96.0
92.8
111
131
(61.6 134)
(61.6 130)
(79.8 150)
(64.1 158)
226
215
240
223
(178 290)
(153 314)
(190 353)
(180 280)
578
519
715
375
(489 687)
(406 844)
(438 942)
(309 876)
188
67
48
73
245
220
267
328
(207 291)
(172 281)
(204 350)
(284 378)
110
98.4
119
166
(61.1 132)
(60.0 130)
(88.5 144)
(120 215)
248
225
252
353
(188 316)
(161 293)
(148 396)
(281 398)
558
449
613
528
(421 749)
(352 1,110)
(517 766)
(469 739)
187
65
45
77
Males
Females
230
230
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
157
149
161
171
(148 167)
(136 164)
(144 180)
(155 189)
78.0
78.7
72.4
89.5
(72.0 84.1)
(71.8 85.0)
(65.0 82.5)
(61.4 102)
151
148
149
171
(142 162)
(126 164)
(135 175)
(152 193)
326
309
333
316
(270 421)
(221 430)
(288 508)
(265 397)
310
126
98
86
154
146
163
164
(138 172)
(126 169)
(128 206)
(130 205)
74.0
71.0
72.7
98.3
(53.3 82.4)
(47.0 79.4)
(42.6 81.3)
(60.8 114)
157
145
168
152
(132 174)
(122 168)
(115 204)
(123 206)
323
305
371
280
(267 437)
(220 863)
(231 814)
(222 430)
143
58
42
43
159
152
160
176
(142 178)
(132 175)
(134 190)
(150 205)
84.4
85.4
71.3
89.4
(71.0 90.6)
(75.5 94.4)
(58.4 86.2)
(49.9 104)
149
147
144
178
(134 172)
(121 167)
(112 205)
(142 235)
331
314
317
322
(254 494)
(190 543)
(255 1,360)
(251 548)
167
68
56
43
Males
Females
221
199
229
243
(208 236)
(184 215)
(208 251)
(221 267)
109
95.5
107
125
(99.2 116)
(84.0 109)
(96.8 126)
(114 136)
221
191
230
247
(201 237)
(174 207)
(214 253)
(219 272)
453
406
462
484
(411 498)
(348 496)
(409 525)
(415 556)
990
300
279
411
208
190
222
211
(189 229)
(164 221)
(196 252)
(192 232)
95.8
83.9
98.2
113
(81.2 108)
(69.1 97.2)
(74.3 111)
(92.1 124)
202
185
223
201
(182 231)
(159 215)
(175 277)
(182 241)
447
359
470
392
(386 520)
(319 554)
(410 582)
(343 481)
471
128
140
203
234
206
235
273
(219 249)
(187 228)
(216 256)
(238 314)
122
109
130
138
(108 133)
(91.9 118)
(99.9 146)
(108 165)
232
194
239
274
(220 250)
(173 221)
(220 257)
(243 303)
455
414
452
550
(408 538)
(346 644)
(362 532)
(460 661)
519
172
139
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
231
231
232
232
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
152
129
146
145
147
131
148
168
146
(138 166)
(120 138)
(140 152)
(139 151)
(141 153)
(126 138)
(143 154)
(162 173)
(141 150)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
65.9
69.5
77.0
71.5
77.7
65.6
76.4
94.1
75.3
(55.7 82.7)
(54.5 74.7)
(62.1 85.4)
(62.4 81.2)
(61.8 81.7)
(58.6 75.3)
(64.4 85.5)
(85.3 102)
(65.1 81.0)
80.9
74.8
86.7
83.4
85.8
76.9
86.6
103
83.6
(58.0 93.1)
(68.0 80.3)
(75.1 93.1)
(70.4 90.3)
(75.4 92.0)
(63.3 82.7)
(75.1 95.5)
(93.4 109)
(76.2 89.7)
146
125
144
141
145
129
144
166
143
(136 164)
(117 134)
(139 149)
(135 148)
(139 151)
(122 137)
(139 150)
(162 172)
(139 148)
262
(251 274)
303
(283 344)
304
237
260
265
260
235
282
266
(258 378)
(206 354)
(242 275)
(242 301)
(240 282)
(214 259)
(251 309)
(258 297)
336
295
298
325
301
269
333
301
(326 384)
(251 429)
(275 337)
(277 390)
(273 345)
(248 344)
(298 533)
(278 344)
373
305
958
845
917
589
501
672
1,762
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
200
100
Females
Males
2039
60+
2039
60+
NonHispanic Whites
100
200
300
4059
4059
NonHispanic Blacks
2039
4059
60+
2039
60+
Males
200
300
Females
4059
100
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Mexican Americans
300
Overall
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
233
233
146
131
148
168
(141 150)
(126 138)
(143 154)
(162 173)
95.1
87.0
99.9
113
(89.2 99.8)
(78.0 93.7)
(92.1 104)
(107 119)
143
129
144
166
(139 148)
(122 137)
(139 150)
(162 172)
225
200
229
242
(216 234)
(190 215)
(211 262)
(231 259)
1,762
589
501
672
145
132
149
160
(139 151)
(126 139)
(139 160)
(153 167)
95.1
87.9
99.8
109
(87.8 102)
(73.4 94.8)
(85.5 105)
(97.2 117)
141
129
146
161
(135 148)
(123 138)
(133 159)
(150 168)
222
197
240
226
(210 241)
(184 222)
(208 301)
(215 258)
845
273
242
330
147
131
147
174
(141 153)
(123 139)
(140 154)
(166 181)
95.0
85.8
99.8
117
(88.5 99.8)
(78.0 92.8)
(87.5 105)
(107 127)
145
129
144
172
(139 151)
(119 138)
(139 147)
(163 182)
227
203
219
248
(213 238)
(190 222)
(187 301)
(237 273)
917
316
259
342
Males
Females
152
140
168
179
(138 166)
(125 157)
(146 192)
(171 187)
97.2
83.4
102
123
(66.3 108)
(55.7 108)
(90.0 110)
(73.1 139)
146
140
157
177
(136 164)
(125 154)
(145 183)
(169 184)
240
226
270
277
(222 324)
(188 347)
(240 375)
(247 310)
373
130
92
151
151
139
175
167
(130 176)
(117 166)
(142 216)
(142 197)
94.6
83.3
103
101
(58.1 111)
(58.1 108)
(88.8 127)
(68.8 140)
144
136
159
155
(127 178)
(117 168)
(139 212)
(140 209)
255
224
321
263
(217 331)
(179 350)
(229 454)
(217 634)
187
66
47
74
152
141
159
190
(142 162)
(124 160)
(133 191)
(173 210)
97.2
87.7
98.6
130
(72.8 104)
(57.9 102)
(81.2 109)
(110 142)
153
144
151
187
(137 167)
(113 169)
(125 188)
(165 214)
235
221
246
284
(222 261)
(186 410)
(197 421)
(228 375)
186
64
45
77
Males
Females
234
234
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
129
119
133
151
(120 138)
(107 134)
(121 146)
(145 157)
82.6
80.5
80.1
108
(74.8 88.4)
(63.7 84.9)
(69.5 89.8)
(99.6 115)
125
112
124
143
(117 134)
(99.8 134)
(118 135)
(141 147)
202
184
204
218
(186 225)
(155 395)
(187 266)
(191 303)
305
124
96
85
129
118
136
151
(119 139)
(104 133)
(117 158)
(136 168)
79.8
72.2
80.3
108
(71.9 84.8)
(54.1 82.8)
(69.7 90.3)
(89.1 116)
124
114
121
147
(117 134)
(89.0 136)
(117 132)
(136 168)
205
185
221
217
(185 235)
(136 435)
(188 409)
(179 250)
141
57
41
43
129
121
130
150
(116 143)
(102 142)
(117 145)
(139 162)
84.9
82.6
76.7
108
(67.1 94.9)
(56.8 94.3)
(66.9 92.1)
(102 124)
126
111
128
141
(111 139)
(99.1 140)
(115 136)
(136 148)
197
177
197
214
(165 284)
(153 284)
(163 575)
(180 323)
164
67
55
42
Males
Females
146
131
145
168
(140 152)
(123 139)
(139 153)
(162 174)
95.8
88.8
100
113
(89.8 102)
(70.0 95.5)
(89.1 104)
(106 117)
144
127
144
167
(139 149)
(120 138)
(137 149)
(162 172)
222
200
219
247
(211 234)
(183 218)
(199 244)
(231 261)
958
285
270
403
144
131
145
161
(138 150)
(122 140)
(135 156)
(153 169)
96.3
92.8
99.8
109
(89.6 103)
(67.7 97.1)
(84.1 105)
(95.0 116)
141
125
144
163
(132 149)
(117 139)
(127 158)
(151 170)
217
185
224
229
(205 240)
(173 229)
(203 276)
(216 260)
456
121
136
199
148
131
146
174
(141 154)
(122 141)
(137 155)
(166 183)
95.6
87.7
100
116
(87.9 103)
(61.8 95.4)
(86.2 105)
(103 128)
147
130
144
171
(141 152)
(121 139)
(139 148)
(162 183)
226
204
212
253
(209 240)
(187 234)
(180 322)
(235 279)
502
164
134
204
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
235
235
236
236
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2,240
1,810
2,130
2,140
2,070
1,910
2,160
2,360
2,100
(2,060 2,430)
(1,730 1,890)
(2,060 2,200)
(2,060 2,220)
(2,000 2,140)
(1,840 1,980)
(2,100 2,230)
(2,290 2,440)
(2,050 2,150)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
1,110
1,020
1,120
1,140
1,090
1,020
1,160
1,330
1,110
(871 1,240)
(892 1,080)
(990 1,210)
(1,040 1,210)
(972 1,140)
(955 1,080)
(993 1,220)
(1,290 1,400)
(1,030 1,170)
1,270
1,150
1,230
1,230
1,200
1,130
1,280
1,430
1,220
(987 1,340)
(1,010 1,180)
(1,140 1,320)
(1,160 1,300)
(1,130 1,270)
(1,080 1,170)
(1,180 1,350)
(1,340 1,550)
(1,170 1,270)
2,070
(2,000 2,150)
3,850
(3,590 4,220)
4,480
(4,230 4,940)
2,170
1,710
2,120
2,100
2,020
1,840
2,120
2,380
(1,990 2,470)
(1,620 1,830)
(2,020 2,180)
(2,010 2,200)
(1,940 2,140)
(1,750 1,970)
(2,010 2,190)
(2,290 2,450)
4,280
3,180
3,840
4,110
3,810
3,710
4,150
3,850
(3,850 5,240)
(2,890 3,760)
(3,580 4,190)
(3,560 4,930)
(3,490 4,020)
(3,120 4,140)
(3,610 4,800)
(3,490 4,410)
4,940
3,760
4,380
4,930
4,240
4,190
4,790
4,410
(4,400 6,640)
(3,350 8,200)
(4,160 4,930)
(4,500 5,530)
(4,030 4,400)
(3,770 8,650)
(4,290 5,320)
(4,120 4,930)
375
308
986
858
940
608
512
678
1,798
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
3000
Mexican Americans
1000
2000
Females
Males
4000
Overall
2039
60+
2039
60+
NonHispanic Whites
1000
2000
3000
4000
NonHispanic Blacks
4059
4059
2039
60+
2039
60+
Males
3000
4000
Females
4059
1000
2000
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
237
237
2,100
1,910
2,160
2,360
(2,050 2,150)
(1,840 1,980)
(2,100 2,230)
(2,290 2,440)
1,360
1,240
1,410
1,630
(1,310 1,400)
(1,200 1,300)
(1,350 1,530)
(1,550 1,690)
2,070
1,840
2,120
2,380
(2,000 2,150)
(1,750 1,970)
(2,010 2,190)
(2,290 2,450)
3,230
2,900
3,380
3,360
(3,090 3,440)
(2,710 3,160)
(3,100 3,660)
(3,200 3,640)
1,798
608
512
678
2,140
1,960
2,250
2,310
(2,060 2,220)
(1,850 2,080)
(2,120 2,400)
(2,220 2,400)
1,360
1,240
1,410
1,600
(1,310 1,410)
(1,220 1,310)
(1,310 1,550)
(1,400 1,730)
2,100
1,890
2,200
2,340
(2,010 2,200)
(1,770 2,060)
(1,970 2,350)
(2,170 2,420)
3,340
2,950
3,580
3,310
(3,060 3,660)
(2,640 3,700)
(3,180 4,480)
(3,040 3,850)
858
281
247
330
2,070
1,860
2,080
2,410
(2,000 2,140)
(1,790 1,940)
(2,000 2,160)
(2,280 2,530)
1,380
1,220
1,400
1,660
(1,300 1,410)
(1,140 1,300)
(1,330 1,520)
(1,480 1,740)
2,020
1,780
2,000
2,430
(1,940 2,140)
(1,700 1,940)
(1,920 2,140)
(2,270 2,530)
3,180
2,820
3,100
3,410
(2,960 3,370)
(2,570 3,620)
(2,830 3,700)
(3,260 3,820)
940
327
265
348
Males
Females
2,240
2,080
2,460
2,630
(2,060 2,430)
(1,850 2,350)
(2,220 2,730)
(2,460 2,820)
1,410
1,320
1,610
1,800
(1,250 1,500)
(882 1,470)
(1,140 1,790)
(1,740 1,820)
2,170
2,020
2,330
2,650
(1,990 2,470)
(1,710 2,390)
(2,090 2,670)
(2,320 2,900)
3,680
3,330
4,210
3,730
(3,330 4,270)
(2,900 4,590)
(3,520 5,160)
(3,570 4,720)
375
132
93
150
2,240
2,080
2,560
2,460
(1,970 2,540)
(1,720 2,500)
(2,160 3,040)
(2,160 2,800)
1,410
1,340
1,550
1,790
(1,150 1,510)
(989 1,480)
(1,280 1,980)
(1,030 1,830)
2,160
1,930
2,490
2,350
(1,820 2,570)
(1,530 2,550)
(2,000 3,090)
(1,900 3,040)
3,940
3,390
4,270
3,440
(3,120 4,880)
(2,640 5,270)
(3,570 5,640)
(3,270 4,860)
188
67
48
73
2,240
2,090
2,350
2,800
(2,060 2,450)
(1,810 2,410)
(2,020 2,730)
(2,470 3,180)
1,400
1,240
1,590
1,890
(859 1,680)
(831 1,570)
(1,080 1,770)
(1,600 2,040)
2,160
2,020
2,200
2,730
(2,020 2,500)
(1,750 2,330)
(1,990 2,730)
(2,320 3,420)
3,500
3,210
3,760
4,260
(3,280 3,970)
(2,850 4,200)
(2,920 5,280)
(3,660 5,490)
187
65
45
77
Males
Females
238
238
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
1,810
1,680
1,900
2,000
(1,730 1,890)
(1,560 1,810)
(1,750 2,050)
(1,870 2,150)
1,210
1,170
1,240
1,400
(1,170 1,260)
(1,050 1,210)
(1,060 1,310)
(1,190 1,570)
1,710
1,540
1,790
1,960
(1,620 1,830)
(1,470 1,760)
(1,640 1,970)
(1,800 2,190)
2,750
2,470
2,840
2,800
(2,610 2,990)
(2,310 3,740)
(2,610 3,590)
(2,670 3,020)
308
125
97
86
1,850
1,710
2,000
1,980
(1,720 1,990)
(1,540 1,910)
(1,730 2,310)
(1,730 2,270)
1,200
1,140
1,290
1,350
(1,140 1,240)
(887 1,230)
(1,010 1,410)
(1,080 1,620)
1,720
1,560
1,850
1,960
(1,570 1,920)
(1,380 1,830)
(1,600 2,060)
(1,700 2,140)
2,930
2,480
3,160
2,870
(2,470 4,190)
(2,400 6,770)
(2,570 8,560)
(2,440 4,520)
142
57
42
43
1,770
1,650
1,820
2,010
(1,670 1,890)
(1,510 1,810)
(1,640 2,030)
(1,880 2,160)
1,210
1,160
1,200
1,410
(1,150 1,280)
(1,080 1,250)
(863 1,280)
(1,280 1,590)
1,700
1,540
1,760
1,930
(1,600 1,840)
(1,470 1,710)
(1,620 2,010)
(1,700 2,400)
2,660
2,430
2,620
2,780
(2,460 2,960)
(2,130 3,240)
(2,360 6,740)
(2,640 3,030)
166
68
55
43
Males
Females
2,130
1,940
2,150
2,390
(2,060 2,200)
(1,820 2,050)
(2,070 2,220)
(2,310 2,470)
1,390
1,260
1,400
1,650
(1,320 1,480)
(1,140 1,360)
(1,320 1,550)
(1,530 1,730)
2,120
1,870
2,140
2,420
(2,020 2,180)
(1,750 2,040)
(2,030 2,180)
(2,330 2,480)
3,240
2,820
3,320
3,410
(3,100 3,430)
(2,630 3,710)
(3,020 3,600)
(3,250 3,700)
986
299
279
408
2,170
1,990
2,230
2,350
(2,070 2,280)
(1,830 2,170)
(2,080 2,380)
(2,240 2,460)
1,380
1,250
1,390
1,600
(1,290 1,520)
(1,070 1,380)
(1,220 1,570)
(1,390 1,730)
2,150
1,960
2,200
2,400
(2,040 2,240)
(1,760 2,130)
(1,950 2,370)
(2,320 2,470)
3,300
2,830
3,460
3,340
(3,030 3,630)
(2,610 4,110)
(3,020 4,000)
(3,070 4,100)
468
128
140
200
2,090
1,880
2,070
2,430
(2,010 2,180)
(1,770 2,000)
(1,980 2,170)
(2,300 2,560)
1,390
1,260
1,410
1,670
(1,320 1,470)
(1,120 1,360)
(1,100 1,560)
(1,470 1,810)
2,080
1,790
2,010
2,430
(1,970 2,160)
(1,670 2,010)
(1,890 2,160)
(2,250 2,540)
3,200
2,810
3,100
3,470
(2,910 3,660)
(2,530 3,860)
(2,720 3,910)
(3,220 4,060)
518
171
139
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
239
239
240
240
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
15.4
11.7
13.6
13.9
13.4
12.6
13.5
15.6
13.6
(14.4 16.5)
(11.0 12.4)
(13.1 14.2)
(13.3 14.5)
(12.8 14.0)
(12.0 13.3)
(13.0 14.1)
(15.1 16.1)
(13.2 14.1)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
6.86
6.11
6.83
6.70
6.66
6.35
6.96
8.94
6.69
(6.00 8.62)
(5.11 6.37)
(5.83 7.46)
(6.12 7.50)
(5.98 7.01)
(5.53 6.66)
(4.20 7.54)
(7.50 9.41)
(6.33 7.03)
8.65
6.39
7.63
7.68
7.48
6.82
7.59
9.74
7.56
(6.33 9.25)
(6.08 6.85)
(6.70 8.15)
(6.72 8.27)
(6.83 7.84)
(6.35 7.49)
(7.00 8.25)
(8.98 10.3)
(6.83 7.98)
14.7
11.1
13.4
13.5
13.0
12.1
13.2
15.1
13.3
(12.8 13.8)
25.9
(24.2 30.5)
33.1
(29.9 38.3)
(13.7 16.4)
(10.2 12.1)
(12.9 13.8)
(12.9 14.2)
(12.6 13.6)
(11.4 12.9)
(12.3 13.8)
(14.7 15.8)
33.1
23.4
24.9
28.7
24.9
25.8
25.7
26.0
(27.9 40.8)
(21.3 28.1)
(23.5 30.1)
(24.6 33.4)
(23.2 26.6)
(22.7 37.3)
(23.6 31.7)
(24.4 30.4)
38.7
29.4
31.7
37.1
30.1
34.7
31.8
31.1
(33.2 45.9)
(25.1 51.3)
(26.5 39.3)
(31.8 42.5)
(26.1 35.3)
(26.3 45.2)
(27.6 47.0)
(28.1 39.5)
376
310
989
865
940
608
514
683
1,805
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
20
5
10
15
Females
Males
25
Overall
2039
4059
60+
2039
60+
NonHispanic Whites
20
15
10
5
0
25
NonHispanic Blacks
4059
2039
4059
60+
2039
60+
Males
20
5
10
15
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
25
Females
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
241
241
13.6
12.6
13.5
15.6
(13.2 14.1)
(12.0 13.3)
(13.0 14.1)
(15.1 16.1)
8.46
7.85
8.71
10.7
(7.94 8.95)
(6.91 8.20)
(7.75 9.34)
(10.3 10.9)
13.3
12.1
13.2
15.1
(12.8 13.8)
(11.4 12.9)
(12.3 13.8)
(14.7 15.8)
22.2
21.6
22.3
23.1
(21.4 23.2)
(20.3 23.2)
(20.3 24.2)
(21.8 24.6)
1,805
608
514
683
13.9
12.7
14.2
15.6
(13.3 14.5)
(11.9 13.5)
(13.3 15.3)
(15.0 16.2)
8.77
7.88
8.96
10.5
(8.41 8.97)
(6.97 8.43)
(8.39 9.70)
(10.2 10.9)
13.5
12.2
13.9
14.9
(12.9 14.2)
(11.6 13.0)
(12.7 14.7)
(14.4 16.1)
22.8
21.2
23.2
23.5
(21.2 24.7)
(17.8 25.8)
(20.5 31.5)
(21.8 24.8)
865
282
248
335
13.4
12.6
12.9
15.6
(12.8 14.0)
(11.8 13.4)
(12.3 13.6)
(14.9 16.4)
8.18
7.74
8.31
10.8
(7.55 8.94)
(6.79 8.08)
(7.29 9.14)
(9.70 11.4)
13.0
12.0
12.5
15.1
(12.6 13.6)
(10.8 13.2)
(11.9 13.1)
(14.6 15.9)
21.8
21.7
19.9
22.6
(21.0 22.9)
(20.6 23.4)
(18.5 23.0)
(21.6 25.1)
940
326
266
348
Males
Females
15.4
14.6
16.4
17.6
(14.4 16.5)
(13.2 16.2)
(14.8 18.2)
(16.3 19.1)
9.39
8.93
10.2
12.0
(8.68 10.3)
(7.04 9.80)
(7.11 11.7)
(10.4 12.6)
14.7
14.1
15.2
16.7
(13.7 16.4)
(12.1 16.5)
(14.6 16.8)
(14.6 19.8)
26.9
23.5
28.4
27.7
(22.7 33.2)
(20.3 40.8)
(25.1 32.9)
(24.8 37.1)
376
132
93
151
15.4
14.5
17.0
17.0
(13.7 17.3)
(12.0 17.7)
(14.8 19.6)
(14.6 19.7)
9.18
8.87
10.5
11.7
(8.78 10.6)
(7.99 9.35)
(7.01 12.6)
(5.88 13.3)
14.7
14.2
15.3
16.4
(13.3 16.8)
(11.5 16.7)
(14.5 17.7)
(12.8 21.4)
26.1
22.7
30.7
25.3
(21.8 39.8)
(17.5 40.9)
(24.6 44.8)
(21.4 59.6)
189
67
48
74
15.4
14.7
15.7
18.3
(14.4 16.5)
(13.2 16.4)
(13.3 18.6)
(15.9 21.0)
9.59
9.04
9.79
11.9
(6.32 10.4)
(6.32 10.1)
(6.66 11.9)
(9.58 13.0)
15.0
14.0
14.9
16.8
(13.6 16.6)
(11.6 16.6)
(12.8 18.8)
(14.6 21.4)
27.1
23.8
26.4
32.3
(22.6 35.3)
(21.5 38.7)
(19.1 38.4)
(24.3 38.0)
187
65
45
77
Males
Females
242
242
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
11.7
10.9
12.1
13.4
(11.0 12.4)
(9.78 12.1)
(10.9 13.3)
(12.7 14.1)
7.28
6.75
7.40
9.43
(6.35 7.86)
(6.07 7.51)
(5.83 8.31)
(8.18 9.88)
11.1
9.90
11.4
13.1
(10.2 12.1)
(9.05 11.4)
(10.1 12.4)
(12.2 14.6)
20.0
19.7
20.0
19.7
(17.7 22.1)
(15.0 25.9)
(16.8 33.4)
(17.7 24.3)
310
126
98
86
11.9
10.9
12.8
13.6
(11.1 12.8)
(9.62 12.4)
(10.5 15.6)
(12.4 15.0)
7.12
6.33
7.86
9.07
(6.18 7.71)
(5.90 7.47)
(5.24 8.80)
(6.71 10.5)
11.0
9.97
11.1
12.3
(9.88 12.3)
(8.73 12.2)
(9.28 14.0)
(11.2 15.0)
21.2
17.2
21.3
22.3
(17.6 35.8)
(14.7 35.2)
(16.6 61.1)
(18.9 25.7)
143
58
42
43
11.5
10.9
11.5
13.3
(10.4 12.7)
(9.36 12.6)
(10.2 12.9)
(12.4 14.2)
7.29
6.88
7.20
9.42
(6.37 7.99)
(5.96 7.70)
(5.09 7.95)
(8.21 9.77)
11.3
9.60
11.6
13.3
(9.96 12.5)
(8.86 11.9)
(9.98 12.5)
(12.6 14.6)
19.0
20.2
17.6
18.0
(15.8 25.1)
(14.6 26.0)
(14.1 40.8)
(15.3 24.3)
167
68
56
43
Males
Females
13.6
12.6
13.3
15.8
(13.1 14.2)
(11.8 13.6)
(12.7 13.9)
(15.2 16.3)
8.60
7.88
8.71
10.8
(7.88 9.22)
(6.83 8.26)
(7.53 9.56)
(10.4 11.1)
13.4
12.1
13.0
15.2
(12.9 13.8)
(11.4 13.0)
(11.9 13.7)
(14.7 15.9)
22.0
21.6
21.7
23.1
(20.7 23.3)
(19.4 24.2)
(19.0 23.1)
(21.7 25.4)
989
298
279
412
13.9
12.5
13.9
15.8
(13.2 14.5)
(11.5 13.7)
(12.9 15.0)
(15.1 16.6)
8.91
7.92
8.97
10.6
(8.24 9.44)
(6.33 8.95)
(7.92 9.80)
(10.2 11.2)
13.6
11.9
13.8
15.3
(12.9 14.2)
(11.4 13.0)
(11.9 14.7)
(14.7 16.4)
22.2
18.2
22.2
23.4
(20.4 24.2)
(15.7 42.2)
(19.9 25.5)
(21.7 26.6)
472
128
140
204
13.4
12.7
12.6
15.7
(12.8 14.1)
(11.7 13.8)
(11.9 13.4)
(14.9 16.5)
8.17
7.83
8.42
10.9
(7.57 9.08)
(5.75 8.15)
(6.89 9.47)
(10.5 11.4)
13.1
12.3
12.1
15.1
(12.6 13.7)
(10.7 13.7)
(11.7 13.0)
(14.5 15.9)
21.8
21.7
19.0
22.8
(20.5 23.4)
(20.6 25.6)
(17.2 22.9)
(21.2 26.1)
517
170
139
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
243
243
244
244
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3.38
3.81
3.36
3.34
3.54
3.36
3.39
3.67
3.44
(2.83 4.03)
(3.39 4.29)
(2.79 4.05)
(2.85 3.92)
(3.04 4.12)
(2.75 4.11)
(2.89 3.97)
(3.18 4.24)
(2.97 3.99)
< LOD
.673
< LOD
< LOD
.334
< LOD
.310
.421
< LOD
.692
1.43
.613
.620
.941
.612
.729
.831
.712
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
3.69
3.83
3.54
3.54
3.66
3.46
3.51
3.93
3.62
(3.32 4.29)
(3.46 4.50)
(3.16 4.23)
(3.24 4.04)
(3.33 4.23)
(3.10 4.06)
(3.16 4.23)
(3.55 4.47)
(3.30 4.07)
10.3
(9.50 12.2)
13.6
(11.8 16.6)
10.5
10.8
10.1
10.1
11.0
11.6
9.45
9.69
(7.40 23.0)
(9.41 15.0)
(9.13 12.6)
(9.39 11.9)
(8.65 14.7)
(9.32 16.7)
(8.62 13.4)
(8.60 10.9)
13.3
13.4
13.6
12.9
14.7
14.7
12.6
11.2
(8.78 23.8)
(11.0 20.1)
(11.4 16.8)
(10.9 14.0)
(11.9 17.7)
(12.4 20.1)
(10.8 16.6)
(9.74 15.5)
345
280
863
767
837
533
454
617
1,604
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
Females
Males
Overall
2039
4059
60+
2039
60+
NonHispanic Whites
4
2
0
NonHispanic Blacks
4059
2039
4059
60+
2039
60+
Males
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Females
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
245
245
3.44
3.36
3.39
3.67
(2.97 3.99)
(2.75 4.11)
(2.89 3.97)
(3.18 4.24)
1.38
1.38
1.21
1.55
(.670 1.82)
(< LOD 1.87)
(.624 1.79)
(.813 1.94)
3.62
3.46
3.51
3.93
(3.30 4.07)
(3.10 4.06)
(3.16 4.23)
(3.55 4.47)
8.15
8.64
8.03
7.86
(7.41 9.51)
(7.27 11.3)
(7.04 9.44)
(7.43 8.68)
1,604
533
454
617
3.34
3.33
3.32
3.42
(2.85 3.92)
(2.63 4.20)
(2.85 3.86)
(2.95 3.95)
1.22
1.11
1.21
1.33
(.372 1.85)
(< LOD 1.89)
(.324 1.87)
(.641 1.75)
3.54
3.38
3.68
3.65
(3.24 4.04)
(2.94 4.18)
(3.16 4.39)
(3.35 3.95)
8.37
9.18
8.06
7.93
(7.59 9.60)
(7.58 12.3)
(6.79 9.60)
(7.45 9.69)
767
3.54
3.40
3.46
3.89
(3.04 4.12)
(2.83 4.08)
(2.85 4.19)
(3.33 4.54)
1.47
1.44
1.16
1.77
(.937 1.84)
(.483 1.70)
(.666 1.76)
(.727 2.27)
3.66
3.58
3.44
4.25
(3.33 4.23)
(2.95 4.23)
(3.03 4.43)
(3.69 5.32)
7.82
7.58
7.92
7.69
(7.24 9.41)
(6.98 14.6)
(7.18 11.5)
(7.38 8.54)
837
284
235
318
Males
Females
249
219
299
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
3.38
3.70
2.97
3.04
(2.83 4.03)
(2.96 4.62)
(2.04 4.31)
(2.44 3.79)
1.47
1.58
1.20
1.48
(.698 1.86)
(< LOD 2.35)
(< LOD 1.85)
(< LOD 1.90)
3.69
3.97
3.45
3.41
(3.32 4.29)
(3.54 4.50)
(2.09 4.69)
(2.89 3.83)
7.40
7.41
7.48
6.86
(6.31 12.3)
(6.18 16.2)
(5.26 12.2)
(5.67 12.0)
345
117
91
137
3.57
3.72
3.47
3.00
(2.84 4.49)
(2.68 5.16)
(2.50 4.81)
(1.75 5.14)
1.51
1.38
1.47
1.47
3.93
4.00
3.82
3.41
(3.52 4.30)
(3.27 4.92)
(2.77 4.66)
(1.76 5.76)
8.15
7.88
8.18
7.10
(6.07 23.8)
(6.00 23.8)
(5.28 11.5)
(5.04 13.1)
170
3.16
3.67
2.48
3.08
(2.54 3.92)
(3.03 4.43)
(1.54 3.98)
(2.53 3.75)
1.43
1.68
.740
1.48
3.55
3.76
2.87
3.39
(2.85 4.70)
(3.30 4.88)
(1.88 4.31)
(2.65 3.84)
6.83
7.10
6.29
6.46
(5.85 7.88)
(5.69 18.2)
(4.79 12.2)
(4.82 10.8)
175
59
44
72
Males
Females
58
47
65
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
246
246
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3.81
3.52
4.04
4.28
(3.39 4.29)
(2.85 4.34)
(3.53 4.64)
(3.65 5.01)
1.76
1.68
1.64
2.24
(.712 2.22)
(< LOD 2.11)
(< LOD 2.46)
(.542 2.55)
3.83
3.54
4.52
4.19
(3.46 4.50)
(3.15 4.17)
(3.73 5.02)
(3.30 5.58)
8.37
8.10
8.15
8.49
(7.02 13.4)
(5.61 23.4)
(7.20 11.6)
(7.12 19.0)
280
116
82
82
3.66
3.31
3.95
4.34
(3.11 4.30)
(2.46 4.44)
(3.14 4.96)
(3.73 5.05)
1.82
1.50
1.76
1.86
3.63
3.28
4.00
3.87
(3.08 4.53)
(2.35 4.53)
(3.07 5.03)
(3.28 6.41)
9.58
7.50
9.73
9.45
(7.05 13.4)
(5.46 23.8)
(6.86 14.6)
(8.02 19.0)
130
3.94
3.70
4.12
4.24
(3.40 4.56)
(2.87 4.77)
(3.48 4.89)
(3.22 5.58)
1.75
1.68
1.57
2.30
(1.28 2.16)
(< LOD 2.25)
(.381 2.46)
(1.77 2.61)
4.14
3.57
4.86
4.23
(3.39 4.92)
(3.18 4.43)
(3.40 6.24)
(2.58 6.59)
8.10
8.27
8.08
7.56
(6.84 16.2)
(5.30 19.7)
(6.93 11.9)
(6.37 11.8)
150
62
47
41
Males
Females
54
35
41
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
3.36
3.21
3.33
3.63
(2.79 4.05)
(2.41 4.27)
(2.77 4.01)
(3.07 4.29)
1.18
1.09
1.11
1.49
(.420 1.78)
(< LOD 1.87)
(.402 1.71)
(.647 1.90)
3.54
3.37
3.44
3.93
(3.16 4.23)
(2.71 4.30)
(2.98 4.49)
(3.52 4.55)
8.12
8.51
8.10
7.77
(7.40 9.59)
(7.27 11.9)
(6.96 11.0)
(7.44 8.50)
863
255
242
366
3.21
3.10
3.21
3.38
(2.64 3.91)
(2.19 4.39)
(2.69 3.82)
(2.85 4.02)
1.09
.749
1.08
1.37
3.48
3.20
3.52
3.63
(3.05 4.20)
(2.56 4.88)
(3.01 4.38)
(3.33 4.15)
8.14
8.97
7.62
7.79
(7.22 9.56)
(7.37 12.8)
(5.91 9.68)
(6.98 9.24)
412
3.51
3.31
3.46
3.85
(2.89 4.25)
(2.57 4.24)
(2.74 4.36)
(3.20 4.63)
1.36
1.37
1.09
1.54
(.604 1.76)
(< LOD 1.89)
(.381 1.71)
(.484 2.18)
3.66
3.61
3.43
4.22
(3.21 4.30)
(2.73 4.30)
(2.89 5.00)
(3.61 5.48)
7.92
7.62
8.43
7.71
(7.38 10.4)
(6.64 16.9)
(7.34 13.9)
(7.39 8.61)
451
145
120
186
Males
Females
110
122
180
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
247
247
248
248
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
74.4
77.3
74.1
72.0
77.7
72.2
74.3
81.0
74.9
(71.0 78.0)
(72.1 82.8)
(71.3 77.0)
(69.5 74.5)
(74.8 80.7)
(68.7 75.8)
(71.5 77.1)
(77.7 84.6)
(72.4 77.4)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
46.4
44.4
45.0
44.3
47.9
44.5
46.4
44.1
45.6
(32.6 52.8)
(23.7 49.2)
(42.5 46.4)
(40.3 45.9)
(44.6 50.0)
(40.1 45.9)
(34.9 50.4)
(41.8 49.9)
(42.9 47.8)
51.4
49.3
49.2
47.0
51.6
47.8
51.2
50.7
49.8
(43.8 54.3)
(38.9 53.8)
(45.4 51.8)
(44.5 50.9)
(47.0 55.3)
(44.5 51.6)
(46.2 53.2)
(44.6 53.2)
(45.9 52.0)
76.0
77.5
74.0
71.9
77.6
72.1
74.1
79.9
75.0
(72.0 77.7)
116
(112 121)
126
(122 134)
(71.1 77.9)
(72.6 81.8)
(71.0 77.4)
(69.8 74.4)
(74.3 80.0)
(67.8 77.2)
(71.4 77.6)
(77.2 84.8)
108
123
117
109
121
109
109
128
(101 121)
(115 131)
(111 122)
(105 114)
(116 126)
(103 115)
(105 121)
(121 138)
115
129
127
118
131
118
123
137
(108 157)
(124 161)
(122 135)
(113 127)
(124 141)
(112 126)
(113 140)
(129 161)
373
288
914
816
880
573
492
631
1,696
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
100
Mexican Americans
50
Females
Males
150
Overall
2039
60+
2039
60+
NonHispanic Whites
50
100
150
NonHispanic Blacks
4059
4059
2039
60+
2039
60+
Males
100
150
Females
4059
50
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
249
249
74.9
72.2
74.3
81.0
(72.4 77.4)
(68.7 75.8)
(71.5 77.1)
(77.7 84.6)
54.4
53.0
55.0
55.9
(51.9 56.6)
(48.3 56.2)
(52.8 57.6)
(51.8 60.0)
75.0
72.1
74.1
79.9
(72.0 77.7)
(67.8 77.2)
(71.4 77.6)
(77.2 84.8)
103
97.3
98.7
118
(99.6 108)
(94.2 103)
(94.9 105)
(110 124)
1,696
573
492
631
72.0
70.9
72.1
73.9
(69.5 74.5)
(67.0 75.0)
(69.4 74.9)
(70.9 77.0)
52.8
52.5
53.1
51.4
(49.8 54.8)
(46.1 55.4)
(47.3 57.2)
(46.3 55.2)
71.9
69.2
72.6
74.2
(69.8 74.4)
(64.8 76.3)
(71.1 74.6)
(71.1 78.3)
98.6
99.1
96.2
103
(95.6 102)
(94.0 106)
(88.9 104)
(98.0 112)
816
267
240
309
77.7
73.4
76.4
87.3
(74.8 80.7)
(70.0 77.0)
(73.2 79.8)
(82.8 92.0)
56.9
53.9
57.4
62.0
(52.7 59.5)
(48.4 58.2)
(51.9 59.8)
(55.7 65.4)
77.6
74.9
76.8
86.3
(74.3 80.0)
(71.5 77.6)
(70.4 81.2)
(80.7 92.6)
107
96.9
101
123
(101 115)
(92.9 104)
(97.7 109)
(119 135)
880
306
252
322
Males
Females
74.4
73.9
73.9
78.6
(71.0 78.0)
(69.6 78.6)
(69.3 78.6)
(74.8 82.7)
55.3
55.3
54.3
58.7
(50.7 58.6)
(43.9 58.9)
(46.6 58.8)
(50.2 62.1)
76.0
75.8
74.0
80.2
(71.1 77.9)
(70.4 77.8)
(69.0 81.3)
(76.6 82.5)
99.1
96.1
96.6
105
(93.7 107)
(93.3 108)
(89.4 122)
(98.7 115)
373
129
93
151
74.2
74.0
74.1
76.6
(71.0 77.6)
(70.5 77.6)
(68.4 80.2)
(69.3 84.7)
55.5
54.5
55.7
53.2
(52.7 57.7)
(46.3 58.7)
(46.0 59.9)
(39.5 63.4)
73.5
72.2
70.1
78.0
(70.5 77.7)
(69.5 78.7)
(66.9 80.6)
(66.3 88.3)
99.6
94.9
102
104
(93.4 107)
(91.2 107)
(89.0 127)
(97.5 157)
187
65
48
74
74.6
73.9
73.6
80.5
(69.7 79.9)
(67.3 81.2)
(67.1 80.8)
(74.5 87.0)
55.2
55.3
50.9
60.5
(45.9 59.3)
(43.1 59.1)
(44.5 59.4)
(32.6 67.0)
77.2
77.1
78.4
80.6
(67.2 82.0)
(63.6 79.7)
(63.4 85.5)
(73.5 88.3)
96.6
98.6
92.1
104
(90.8 116)
(89.2 129)
(86.2 121)
(92.5 159)
186
64
45
77
Males
Females
250
250
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
77.3
73.1
79.9
84.1
(72.1 82.8)
(67.2 79.6)
(74.1 86.2)
(74.8 94.6)
54.4
50.9
56.3
55.3
(49.3 57.4)
(44.3 55.8)
(50.0 61.9)
(43.3 59.2)
77.5
74.1
78.7
87.7
(72.6 81.8)
(67.5 79.8)
(72.8 81.6)
(77.2 94.2)
110
101
112
122
(102 121)
(93.6 128)
(99.6 137)
(114 131)
288
116
93
79
74.4
69.3
78.9
82.3
(67.7 81.8)
(58.5 82.0)
(72.2 86.3)
(73.6 92.0)
53.3
45.2
56.7
54.7
(45.2 55.5)
(23.7 53.9)
(53.9 66.2)
(49.6 62.2)
74.4
67.4
76.6
84.5
(67.4 81.1)
(60.3 80.6)
(68.8 81.4)
(59.7 104)
111
104
109
117
(97.0 128)
(81.7 129)
(94.2 133)
(104 129)
133
54
40
39
79.6
76.6
80.6
85.3
(73.4 86.4)
(68.7 85.4)
(72.3 90.0)
(71.6 102)
55.7
55.6
55.5
51.8
(50.1 60.1)
(48.6 61.3)
(43.4 62.9)
(39.7 62.8)
79.3
75.4
79.2
89.2
(73.1 88.6)
(70.3 86.2)
(71.0 89.5)
(75.8 95.2)
109
98.9
112
123
(101 123)
(92.0 123)
(101 160)
(101 167)
155
62
53
40
Males
Females
74.1
70.5
73.2
81.0
(71.3 77.0)
(66.5 74.8)
(70.1 76.5)
(77.1 85.1)
53.5
51.9
53.9
55.4
(51.3 56.2)
(45.2 56.2)
(51.0 57.6)
(51.8 58.7)
74.0
70.7
73.6
79.9
(71.0 77.4)
(64.8 76.2)
(69.8 77.6)
(75.7 85.4)
102
94.0
97.6
118
(98.6 109)
(88.1 109)
(91.9 108)
(109 132)
914
281
265
368
70.6
68.4
71.0
73.0
(68.1 73.1)
(64.3 72.7)
(67.8 74.5)
(70.0 76.1)
52.1
52.0
52.8
50.9
(48.1 54.1)
(43.7 55.7)
(46.3 54.4)
(43.5 54.8)
71.0
66.3
72.3
73.7
(68.4 73.4)
(61.7 73.0)
(70.9 74.2)
(68.5 78.8)
97.2
92.2
93.2
102
(90.7 101)
(84.4 109)
(86.4 107)
(93.9 113)
437
120
135
182
77.5
72.5
75.5
88.4
(73.8 81.3)
(67.9 77.5)
(71.7 79.4)
(83.1 94.1)
56.2
51.9
57.2
61.8
(51.9 59.2)
(45.2 57.6)
(51.9 59.3)
(53.5 68.4)
77.4
74.1
74.7
88.3
(72.4 81.0)
(68.9 78.3)
(68.4 80.7)
(79.8 96.5)
108
96.1
100
126
(101 119)
(90.0 115)
(94.7 109)
(119 137)
477
161
130
186
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
251
251
252
252
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(3,390 3,510)
(3,260 3,410)
(3,440 3,600)
(3,430 3,600)
(3,300 3,470)
(3,430 3,580)
(3,570 3,900)
(3,090 3,340)
(3,370 3,510)
3,450
3,340
3,520
3,520
3,380
3,500
3,730
3,210
3,440
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
2,320
2,140
2,210
2,240
2,170
2,150
2,230
2,250
2,210
(1,840 2,480)
(1,850 2,200)
(2,020 2,300)
(2,120 2,310)
(1,910 2,340)
(1,830 2,290)
(1,740 2,360)
(1,960 2,320)
(2,070 2,300)
2,490
2,250
2,360
2,340
2,420
2,340
2,420
2,360
2,370
(2,330 2,610)
(2,110 2,360)
(2,270 2,500)
(2,310 2,410)
(2,300 2,540)
(2,200 2,460)
(2,250 2,570)
(2,280 2,490)
(2,310 2,450)
3,430
(3,370 3,520)
4,980
(4,810 5,190)
5,410
(5,140 5,840)
3,660
3,130
3,440
3,360
3,530
3,310
3,500
3,570
(3,510 3,900)
(3,030 3,230)
(3,360 3,540)
(3,240 3,450)
(3,450 3,600)
(3,240 3,370)
(3,410 3,620)
(3,480 3,640)
5,800
4,610
4,950
4,900
5,040
4,810
5,060
5,090
(5,270 6,570)
(4,460 4,810)
(4,800 5,080)
(4,640 5,360)
(4,880 5,280)
(4,630 5,230)
(4,830 5,610)
(4,870 5,220)
6,320
4,960
5,190
5,240
5,500
5,250
5,550
5,440
(5,810 7,000)
(4,640 8,680)
(5,050 5,780)
(5,090 5,810)
(5,100 5,900)
(4,910 6,260)
(5,110 5,880)
(5,160 5,890)
375
310
991
863
943
610
515
681
1,806
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Sample
Geometric mean
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
size
( 95% conf. interval)
4000
Mexican Americans
2000
Females
Males
6000
Overall
2039
60+
2039
60+
NonHispanic Whites
2000
4000
6000
NonHispanic Blacks
4059
4059
2039
60+
2039
60+
Males
4000
6000
Females
4059
2000
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
253
253
3,450
3,340
3,520
3,520
(3,390 3,510)
(3,260 3,410)
(3,440 3,600)
(3,430 3,600)
2,610
2,570
2,700
2,690
(2,550 2,700)
(2,470 2,610)
(2,520 2,780)
(2,480 2,790)
3,430
3,310
3,500
3,570
(3,370 3,520)
(3,240 3,370)
(3,410 3,620)
(3,480 3,640)
4,570
4,410
4,700
4,580
(4,410 4,730)
(4,280 4,670)
(4,510 4,830)
(4,410 4,870)
1,806
610
515
681
3,380
3,280
3,530
3,320
(3,300 3,470)
(3,190 3,380)
(3,430 3,620)
(3,220 3,420)
2,590
2,510
2,710
2,420
(2,480 2,680)
(2,420 2,600)
(2,600 2,790)
(2,320 2,570)
3,360
3,210
3,490
3,370
(3,240 3,450)
(3,150 3,320)
(3,350 3,640)
(3,180 3,510)
4,510
4,380
4,610
4,310
(4,240 4,720)
(4,030 4,910)
(4,350 4,860)
(4,160 4,680)
863
282
248
333
3,500
3,390
3,510
3,690
(3,430 3,580)
(3,270 3,510)
(3,390 3,630)
(3,580 3,800)
2,640
2,590
2,630
2,870
(2,580 2,740)
(2,530 2,630)
(2,350 2,860)
(2,770 2,940)
3,530
3,390
3,530
3,700
(3,450 3,600)
(3,280 3,520)
(3,420 3,620)
(3,600 3,790)
4,660
4,420
4,790
4,820
(4,490 4,820)
(4,270 4,860)
(4,380 5,030)
(4,540 5,080)
943
328
267
348
Males
Females
3,730
3,630
3,920
3,860
(3,570 3,900)
(3,350 3,920)
(3,720 4,130)
(3,540 4,210)
2,700
2,620
2,900
2,910
(2,500 2,900)
(2,350 2,730)
(2,410 3,150)
(2,120 3,360)
3,660
3,530
3,810
3,840
(3,510 3,900)
(3,280 3,960)
(3,690 4,100)
(3,530 4,250)
5,170
5,120
5,370
5,050
(4,740 5,900)
(4,570 6,320)
(4,730 7,050)
(4,590 6,170)
375
132
93
150
3,700
3,600
3,890
3,750
(3,460 3,950)
(3,220 4,040)
(3,610 4,200)
(3,490 4,030)
2,630
2,490
3,010
2,750
(2,330 2,910)
(2,310 2,860)
(2,020 3,250)
(2,170 3,290)
3,640
3,500
3,860
3,760
(3,280 4,140)
(3,030 4,300)
(3,600 4,150)
(3,580 3,990)
5,100
5,020
5,050
4,960
(4,650 6,350)
(4,440 6,640)
(4,530 7,450)
(4,330 5,580)
188
67
48
73
3,780
3,660
3,950
3,970
(3,610 3,960)
(3,320 4,030)
(3,680 4,250)
(3,440 4,580)
2,710
2,710
2,720
2,920
(2,260 3,040)
(1,840 3,050)
(2,350 3,130)
(2,120 3,520)
3,680
3,550
3,780
3,930
(3,530 3,920)
(3,470 3,910)
(3,580 4,330)
(3,450 4,570)
5,260
5,130
5,440
5,080
(4,810 5,960)
(4,350 6,500)
(4,800 6,970)
(4,570 6,220)
187
65
45
77
Males
Females
254
254
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3,210
3,140
3,280
3,290
(3,090 3,340)
(2,940 3,340)
(3,110 3,470)
(3,080 3,510)
2,430
2,360
2,540
2,470
(2,350 2,490)
(2,150 2,460)
(2,240 2,690)
(1,190 2,710)
3,130
3,050
3,160
3,410
(3,030 3,230)
(2,860 3,230)
(3,040 3,260)
(3,090 3,550)
4,250
4,200
4,330
4,210
(4,120 4,540)
(4,030 4,570)
(4,100 5,000)
(3,930 5,080)
310
126
98
86
3,190
3,120
3,370
3,050
(3,070 3,320)
(2,900 3,350)
(3,190 3,570)
(2,750 3,380)
2,350
2,320
2,610
2,300
(2,180 2,480)
(1,800 2,450)
(2,200 2,750)
(1,190 2,500)
3,070
3,030
3,160
3,070
(2,980 3,190)
(2,790 3,290)
(2,990 3,280)
(2,730 3,650)
4,380
4,110
4,570
4,010
(3,940 4,840)
(3,750 7,040)
(4,110 8,980)
(3,800 4,250)
143
58
42
43
3,230
3,160
3,220
3,450
(3,050 3,410)
(2,920 3,410)
(3,000 3,440)
(3,190 3,720)
2,460
2,410
2,490
2,640
(2,390 2,560)
(2,220 2,470)
(2,160 2,630)
(2,420 2,910)
3,180
3,100
3,100
3,430
(2,970 3,380)
(2,820 3,340)
(2,910 3,410)
(3,050 3,750)
4,210
4,230
4,120
4,350
(4,040 5,050)
(3,900 5,030)
(3,720 7,490)
(4,100 5,080)
167
68
56
43
Males
Females
3,440
3,330
3,470
3,530
(3,370 3,510)
(3,250 3,420)
(3,370 3,580)
(3,430 3,630)
2,620
2,580
2,690
2,680
(2,530 2,710)
(2,520 2,620)
(2,360 2,830)
(2,420 2,800)
3,440
3,310
3,480
3,590
(3,360 3,540)
(3,250 3,380)
(3,340 3,620)
(3,490 3,690)
4,520
4,360
4,560
4,600
(4,340 4,720)
(4,130 4,730)
(4,300 4,820)
(4,440 4,930)
991
300
280
411
3,360
3,250
3,480
3,330
(3,260 3,470)
(3,140 3,370)
(3,340 3,630)
(3,210 3,450)
2,580
2,530
2,710
2,420
(2,440 2,690)
(2,420 2,600)
(2,430 2,830)
(2,300 2,580)
3,370
3,210
3,480
3,370
(3,210 3,500)
(3,130 3,330)
(3,290 3,650)
(3,090 3,600)
4,330
4,150
4,430
4,320
(4,130 4,740)
(3,860 5,070)
(4,200 4,930)
(4,110 4,780)
471
128
140
203
3,510
3,410
3,470
3,720
(3,430 3,590)
(3,240 3,580)
(3,330 3,610)
(3,580 3,860)
2,660
2,610
2,570
2,900
(2,570 2,770)
(2,430 2,740)
(2,220 2,870)
(2,810 2,970)
3,530
3,390
3,480
3,760
(3,420 3,610)
(3,250 3,580)
(3,340 3,610)
(3,640 3,840)
4,660
4,390
4,720
4,860
(4,480 4,820)
(4,180 4,970)
(4,290 4,940)
(4,530 5,140)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
255
255
256
256
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(60.5 65.8)
(55.8 60.6)
(60.7 69.6)
(65.2 73.0)
(58.8 65.5)
(61.1 67.2)
(63.8 74.5)
(50.4 57.4)
(59.9 66.8)
63.1
58.1
65.0
69.0
62.1
64.1
69.0
53.8
63.3
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
23.9
24.5
25.2
23.0
27.2
24.9
25.1
29.3
25.2
(20.1 30.7)
(13.3 28.8)
(20.0 27.5)
(17.0 26.2)
(23.6 30.6)
(19.9 26.6)
(14.3 30.3)
(20.8 33.2)
(21.4 27.5)
31.8
28.8
29.5
27.6
32.8
27.3
30.8
33.5
30.0
(24.3 36.1)
(23.7 30.8)
(25.8 33.0)
(22.4 31.7)
(27.5 34.7)
(25.2 30.3)
(22.7 35.6)
(28.4 36.4)
(26.0 33.1)
66.2
50.5
62.3
59.9
62.4
57.5
61.2
68.3
61.4
(59.6 73.9)
(48.2 53.1)
(58.9 65.7)
(57.3 64.2)
(59.9 65.5)
(55.2 59.9)
(58.2 66.9)
(64.9 72.3)
(58.9 63.7)
137
(128 151)
165
(153 192)
160
115
133
142
131
127
134
143
(135 246)
(107 147)
(124 153)
(128 172)
(123 150)
(117 150)
(127 162)
(138 154)
199
149
157
173
158
159
174
159
(159 421)
(121 362)
(143 193)
(155 210)
(146 184)
(137 221)
(157 203)
(147 234)
375
310
986
859
942
610
513
678
1,801
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Sample
Geometric mean
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
size
( 95% conf. interval)
100
150
Mexican Americans
50
Females
Males
Plasma alphalinolenic
acid (mol/L)
Overall
2039
4059
60+
2039
60+
50
100
150
NonHispanic Whites
Plasma alphalinolenic
acid (mol/L)
NonHispanic Blacks
4059
2039
4059
60+
2039
60+
100
150
Males
50
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma alphalinolenic
acid (mol/L)
Females
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
257
257
63.1
58.1
65.0
69.0
(60.5 65.8)
(55.8 60.6)
(60.7 69.6)
(65.2 73.0)
35.3
32.9
37.6
39.3
(33.1 38.0)
(30.8 34.2)
(31.3 40.5)
(34.8 43.2)
61.4
57.5
61.2
68.3
(58.9 63.7)
(55.2 59.9)
(58.2 66.9)
(64.9 72.3)
114
107
117
123
(110 121)
(98.2 116)
(110 128)
(112 137)
1,801
610
513
678
62.1
56.9
65.9
65.4
(58.8 65.5)
(53.5 60.6)
(61.5 70.6)
(60.1 71.2)
33.6
31.6
34.5
35.3
(28.6 37.0)
(27.5 34.3)
(23.9 43.7)
(31.7 39.8)
59.9
55.7
63.6
63.8
(57.3 64.2)
(51.2 59.6)
(58.1 72.9)
(57.2 73.8)
116
107
125
120
(110 127)
(98.1 121)
(112 132)
(107 147)
859
282
246
331
64.1
59.3
64.2
72.0
(61.1 67.2)
(56.1 62.7)
(58.4 70.4)
(67.3 77.1)
38.1
34.0
38.5
42.9
(35.1 39.7)
(30.7 36.2)
(34.1 40.6)
(36.5 47.5)
62.4
59.1
58.8
71.1
(59.9 65.5)
(56.0 62.6)
(55.3 65.7)
(66.9 76.6)
113
105
112
123
(106 122)
(93.4 125)
(103 125)
(109 141)
942
328
267
347
Males
Females
69.0
65.6
73.8
76.1
(63.8 74.5)
(56.2 76.6)
(65.4 83.2)
(65.5 88.5)
39.4
36.8
43.8
43.6
(30.2 43.0)
(25.2 41.3)
(30.1 47.8)
(34.4 47.4)
66.2
61.4
70.5
75.9
(59.6 73.9)
(54.6 73.8)
(59.0 88.4)
(67.6 82.9)
133
125
133
136
(117 159)
(111 215)
(115 146)
(108 292)
375
132
93
150
68.9
66.2
74.4
70.6
(61.1 77.7)
(52.3 83.9)
(59.7 92.8)
(60.3 82.5)
40.5
39.3
43.7
39.6
(25.8 43.5)
(22.8 42.6)
(22.7 50.8)
(31.8 47.0)
65.9
58.5
70.4
69.6
(54.6 80.2)
(44.6 86.5)
(55.6 95.9)
(55.1 79.4)
134
130
133
125
(113 201)
(91.9 222)
(105 421)
(94.7 292)
188
67
48
73
69.1
64.7
73.0
81.6
(62.1 76.8)
(51.4 81.5)
(63.4 84.1)
(64.4 103)
37.5
32.7
41.4
45.2
(23.1 44.8)
(20.1 43.7)
(23.1 52.1)
(32.3 58.1)
66.2
63.6
69.0
82.0
(60.2 73.2)
(55.0 73.4)
(54.1 87.9)
(64.8 94.8)
131
125
132
144
(118 147)
(102 278)
(110 194)
(111 197)
187
65
45
77
Males
Females
258
258
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
53.8
50.4
56.2
59.4
(50.4 57.4)
(44.6 56.8)
(52.0 60.6)
(53.3 66.2)
31.8
30.7
32.8
35.9
(29.4 34.0)
(26.4 33.1)
(23.4 36.2)
(29.4 40.4)
50.5
48.1
51.5
60.0
(48.2 53.1)
(43.0 53.0)
(47.1 55.1)
(53.5 63.0)
91.7
76.8
99.0
92.9
(81.0 112)
(69.0 142)
(81.8 315)
(81.4 142)
310
126
98
86
53.4
49.6
57.9
56.4
(48.6 58.7)
(41.2 59.8)
(49.9 67.2)
(48.8 65.1)
29.4
28.8
29.7
30.6
(24.1 32.4)
(13.3 33.5)
(18.1 35.2)
(25.3 39.9)
51.7
45.5
51.6
59.8
(44.9 55.3)
(42.4 57.9)
(40.9 63.7)
(46.2 72.5)
93.3
75.7
124
90.7
(78.9 149)
(65.3 523)
(97.4 284)
(79.0 105)
143
58
42
43
54.1
51.0
54.9
61.4
(50.0 58.5)
(45.7 56.9)
(47.8 62.9)
(53.7 70.1)
34.4
32.7
35.2
38.8
(32.1 37.0)
(28.1 35.9)
(23.1 39.9)
(32.9 43.2)
50.3
48.2
51.2
59.2
(47.5 54.6)
(41.2 57.7)
(44.3 57.6)
(52.0 64.8)
88.9
80.1
84.7
101
(77.4 120)
(67.0 134)
(75.8 332)
(81.5 142)
167
68
56
43
Males
Females
63.3
58.3
64.0
69.4
(59.9 66.8)
(55.5 61.3)
(57.9 70.7)
(65.1 74.0)
34.9
32.4
37.5
39.4
(32.3 38.0)
(30.2 34.1)
(28.1 40.8)
(34.3 44.1)
62.3
58.4
60.5
69.0
(58.9 65.7)
(56.4 61.9)
(57.3 68.0)
(65.1 72.7)
113
103
114
125
(109 120)
(93.8 116)
(108 123)
(111 140)
986
300
278
408
61.8
55.7
64.8
65.8
(58.1 65.7)
(52.2 59.5)
(59.6 70.5)
(60.1 72.1)
33.0
30.6
33.7
36.0
(27.5 36.6)
(26.4 33.7)
(16.1 45.7)
(29.2 41.6)
60.6
55.1
63.6
63.8
(57.4 65.4)
(47.7 60.6)
(58.1 70.8)
(57.1 74.4)
113
103
116
118
(108 124)
(95.6 113)
(108 132)
(109 145)
467
128
138
201
64.7
60.8
63.2
72.5
(61.0 68.5)
(56.7 65.1)
(55.2 72.3)
(67.0 78.5)
38.2
34.0
38.4
41.9
(34.6 40.0)
(30.4 37.3)
(33.6 40.7)
(34.7 48.1)
62.8
61.0
58.4
71.2
(59.8 67.0)
(56.4 66.1)
(52.1 68.1)
(67.3 76.6)
113
103
111
127
(106 121)
(88.8 128)
(102 120)
(108 154)
519
172
140
207
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
259
259
260
260
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
41.8
42.5
48.8
48.0
46.0
41.7
51.0
49.6
46.9
(38.1 45.8)
(40.4 44.7)
(46.1 51.6)
(45.5 50.6)
(43.7 48.4)
(39.4 44.1)
(48.4 53.8)
(45.9 53.6)
(45.0 49.0)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
12.6
16.5
19.2
17.1
16.8
15.0
18.4
18.3
17.1
(6.25 15.0)
(14.9 18.3)
(13.9 21.3)
(13.1 20.3)
(12.8 19.1)
(12.6 17.7)
(15.0 19.4)
(14.4 20.3)
(13.7 19.1)
15.1
20.6
22.1
22.0
19.5
19.3
20.4
22.0
20.2
(9.90 18.6)
(15.8 23.1)
(19.7 23.8)
(18.7 23.5)
(17.0 21.6)
(15.1 21.2)
(18.3 24.0)
(20.3 23.6)
(19.0 22.0)
43.1
42.8
50.5
50.0
47.2
41.9
53.3
51.2
49.0
(38.4 49.9)
(40.0 46.4)
(47.5 53.2)
(48.0 52.4)
(44.0 50.6)
(38.7 46.5)
(50.1 56.4)
(46.1 57.0)
(46.4 51.5)
100
(94.2 106)
117
(107 127)
94.0
84.1
101
99.2
100
85.1
108
102
(89.7 115)
(76.7 112)
(93.4 108)
(90.5 120)
(92.8 106)
(79.1 105)
(96.5 118)
(97.4 119)
116
105
117
120
110
99.8
121
115
(96.3 132)
(86.7 138)
(105 128)
(105 129)
(106 128)
(86.2 140)
(113 129)
(104 142)
375
309
981
855
940
603
513
679
1,795
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
60
80
Mexican Americans
20
40
Females
Males
Plasma gammalinolenic
acid (mol/L)
Overall
2039
4059
60+
2039
40
60
80
NonHispanic Whites
20
2039
4059
60+
2039
4059
60+
Males
60
80
Females
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma gammalinolenic
acid (mol/L)
60+
Plasma gammalinolenic
acid (mol/L)
NonHispanic Blacks
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
261
261
46.9
41.7
51.0
49.6
(45.0 49.0)
(39.4 44.1)
(48.4 53.8)
(45.9 53.6)
24.4
22.5
25.7
26.7
(22.9 25.8)
(20.6 24.1)
(23.4 29.5)
(23.9 29.1)
49.0
41.9
53.3
51.2
(46.4 51.5)
(38.7 46.5)
(50.1 56.4)
(46.1 57.0)
85.7
75.2
90.5
90.8
(82.1 90.3)
(69.9 80.9)
(87.1 94.7)
(82.8 101)
1,795
603
513
679
48.0
45.7
52.7
44.3
(45.5 50.6)
(42.7 48.8)
(49.5 56.2)
(40.3 48.7)
25.6
25.1
26.3
24.7
(23.8 27.0)
(21.7 26.9)
(23.9 30.8)
(19.5 27.7)
50.0
48.8
55.7
44.5
(48.0 52.4)
(44.3 52.1)
(51.5 59.2)
(42.4 48.4)
85.7
79.5
91.9
79.8
(81.2 94.4)
(68.4 90.5)
(85.6 110)
(70.5 101)
855
277
246
332
46.0
38.2
49.5
54.4
(43.7 48.4)
(35.3 41.3)
(46.3 53.0)
(50.0 59.2)
23.0
21.5
24.5
29.1
(21.5 24.8)
(16.6 23.1)
(20.1 27.8)
(26.2 30.6)
47.2
37.3
51.7
57.9
(44.0 50.6)
(34.7 41.3)
(48.2 55.8)
(50.7 64.5)
85.1
73.0
89.7
97.2
(80.4 89.8)
(62.6 79.0)
(81.9 101)
(88.0 105)
940
326
267
347
Males
Females
41.8
38.5
47.4
46.9
(38.1 45.8)
(33.2 44.5)
(42.9 52.3)
(40.9 53.7)
19.5
18.1
24.2
24.0
(15.2 22.8)
(13.0 20.2)
(17.3 27.6)
(13.3 29.1)
43.1
40.4
48.3
48.7
(38.4 49.9)
(32.6 51.1)
(39.6 55.1)
(41.9 61.0)
83.5
71.2
94.9
86.0
(77.3 89.8)
(67.0 87.0)
(81.5 123)
(79.1 89.7)
375
132
93
150
44.2
43.3
47.1
41.1
(38.1 51.2)
(34.6 54.2)
(37.9 58.6)
(33.5 50.5)
20.6
20.1
25.8
21.3
(14.5 26.3)
(7.22 25.2)
(9.42 31.7)
(11.1 25.6)
45.9
46.7
44.7
42.9
(38.4 54.8)
(32.8 60.0)
(38.0 55.2)
(26.9 60.8)
87.3
81.3
94.2
71.0
(74.0 91.6)
(67.1 107)
(70.9 155)
(57.5 131)
188
67
48
73
39.0
32.8
47.6
52.9
(34.4 44.1)
(26.5 40.6)
(41.4 54.8)
(46.0 60.7)
16.5
14.7
21.0
26.6
(10.6 21.9)
(6.25 19.3)
(15.0 27.4)
(9.56 39.1)
40.1
34.6
51.3
55.3
(33.0 50.6)
(29.0 41.4)
(35.0 61.6)
(50.3 62.2)
82.4
61.6
94.9
88.9
(72.2 90.6)
(50.6 89.6)
(81.2 108)
(86.4 98.2)
187
65
45
77
Males
Females
262
262
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
42.5
38.0
49.2
42.9
(40.4 44.7)
(35.1 41.2)
(45.5 53.2)
(40.1 45.9)
23.7
22.1
27.0
25.3
(22.0 25.1)
(18.2 24.1)
(19.9 33.0)
(11.9 30.0)
42.8
37.1
50.1
45.8
(40.0 46.4)
(32.7 41.8)
(48.6 53.3)
(39.8 48.6)
73.7
67.3
82.2
68.5
(68.3 80.0)
(61.8 76.2)
(73.0 111)
(66.3 74.0)
309
125
98
86
44.7
41.7
51.1
40.9
(41.2 48.4)
(37.3 46.6)
(45.1 57.8)
(35.6 46.9)
24.8
23.4
27.9
23.6
(22.5 27.5)
(14.7 26.3)
(23.2 34.8)
(20.0 26.3)
44.2
42.5
48.8
39.8
(38.7 51.2)
(32.5 52.0)
(39.2 58.8)
(33.3 51.3)
75.4
73.1
88.5
69.4
(72.8 88.6)
(60.3 181)
(73.1 121)
(57.4 83.1)
142
57
42
43
40.9
35.3
47.9
44.2
(38.9 43.0)
(32.6 38.2)
(42.3 54.2)
(39.6 49.4)
22.4
21.2
21.8
25.4
(18.9 25.2)
(15.5 24.3)
(17.8 33.3)
(11.9 31.0)
41.7
36.7
50.8
46.8
(37.8 46.2)
(29.9 39.1)
(46.4 54.0)
(36.5 54.0)
69.3
60.0
78.1
68.3
(65.9 78.6)
(50.6 82.2)
(68.2 109)
(61.7 78.4)
167
68
56
43
Males
Females
48.8
44.1
51.9
50.6
(46.1 51.6)
(40.9 47.6)
(48.1 56.0)
(46.1 55.5)
25.6
24.0
26.6
26.8
(23.9 27.8)
(21.8 26.7)
(22.8 32.2)
(22.8 29.6)
50.5
45.3
54.2
52.4
(47.5 53.2)
(39.0 50.9)
(50.0 58.7)
(46.2 58.7)
86.9
76.3
90.3
92.5
(82.2 93.2)
(69.5 84.7)
(86.4 94.7)
(83.2 104)
981
294
278
409
49.6
47.7
54.4
44.7
(46.0 53.4)
(43.6 52.1)
(50.0 59.2)
(39.8 50.3)
26.3
26.3
28.5
24.6
(23.9 29.6)
(22.5 29.5)
(24.0 33.3)
(16.3 28.7)
51.4
49.8
56.9
44.6
(49.0 53.5)
(46.8 52.9)
(51.7 60.7)
(41.8 49.7)
86.1
80.5
92.4
80.9
(79.7 101)
(67.7 115)
(85.5 117)
(67.4 119)
464
124
138
202
48.1
41.3
49.5
56.1
(45.4 50.9)
(37.2 45.8)
(44.8 54.8)
(50.6 62.2)
24.6
23.0
25.4
29.6
(22.4 27.7)
(20.1 25.2)
(19.2 31.5)
(22.8 33.5)
49.1
39.6
50.5
60.6
(45.1 53.5)
(35.8 45.4)
(46.2 56.1)
(52.8 66.0)
87.3
75.5
88.9
97.4
(82.1 92.2)
(64.7 81.7)
(77.0 103)
(88.3 107)
517
170
140
207
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
263
263
264
264
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
25.2
19.2
20.9
20.4
22.0
20.2
21.5
22.8
21.2
(23.5 27.1)
(18.3 20.1)
(20.3 21.5)
(19.7 21.2)
(21.3 22.7)
(19.5 20.9)
(20.6 22.3)
(22.1 23.5)
(20.7 21.8)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
11.4
10.8
11.2
11.4
11.0
10.4
11.7
12.9
11.2
(8.60 13.3)
(9.00 11.2)
(9.83 11.8)
(10.6 11.9)
(10.4 11.4)
(9.44 11.0)
(10.3 12.2)
(10.6 14.0)
(10.5 11.6)
13.3
11.4
12.3
12.6
12.2
11.3
12.8
14.3
12.4
(11.3 14.4)
(10.5 12.5)
(11.7 12.9)
(11.8 13.0)
(11.4 13.0)
(10.7 12.0)
(11.8 13.7)
(13.1 15.3)
(11.9 12.8)
24.9
19.0
20.7
20.2
21.7
19.4
21.2
23.1
20.9
(22.8 26.6)
(18.1 19.7)
(20.1 21.4)
(19.3 21.1)
(21.0 22.3)
(18.6 20.3)
(20.3 22.4)
(22.3 23.6)
(20.3 21.6)
36.9
(35.1 39.9)
42.2
(39.9 47.3)
49.5
33.5
35.0
32.9
38.5
38.5
35.4
35.4
(43.2 69.3)
(28.4 40.5)
(33.5 38.1)
(31.3 37.1)
(36.4 43.8)
(35.8 43.2)
(33.9 40.3)
(33.7 37.4)
55.0
36.3
40.7
40.0
46.5
43.9
42.0
38.6
(49.5 121)
(34.6 51.6)
(36.9 46.5)
(35.1 44.9)
(40.9 49.6)
(40.7 50.1)
(38.1 47.5)
(36.6 46.6)
375
310
990
865
940
607
515
683
1,805
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
30
10
20
Females
Males
Plasma eicosadienoic
acid (mol/L)
40
Overall
2039
4059
60+
2039
60+
NonHispanic Whites
30
20
10
0
Plasma eicosadienoic
acid (mol/L)
40
NonHispanic Blacks
4059
2039
4059
60+
2039
60+
Males
30
10
20
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma eicosadienoic
acid (mol/L)
40
Females
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
265
265
21.2
20.2
21.5
22.8
(20.7 21.8)
(19.5 20.9)
(20.6 22.3)
(22.1 23.5)
14.1
13.0
14.5
16.2
(13.5 14.6)
(12.0 13.7)
(13.2 15.3)
(15.2 16.8)
20.9
19.4
21.2
23.1
(20.3 21.6)
(18.6 20.3)
(20.3 22.4)
(22.3 23.6)
32.0
33.1
30.8
32.2
(30.8 33.8)
(30.9 36.6)
(30.0 33.7)
(31.0 33.4)
1,805
607
515
683
20.4
19.3
21.2
21.4
(19.7 21.2)
(18.4 20.2)
(20.3 22.2)
(20.6 22.2)
13.9
13.1
14.5
15.3
(13.0 14.7)
(11.6 13.9)
(12.9 15.3)
(13.2 16.6)
20.2
19.2
20.9
21.0
(19.3 21.1)
(18.1 19.9)
(19.6 22.8)
(20.3 21.9)
29.6
28.3
30.3
29.5
(28.1 31.3)
(26.4 31.4)
(28.1 32.4)
(28.1 33.4)
865
22.0
21.1
21.7
24.0
(21.3 22.7)
(20.1 22.3)
(20.6 22.9)
(23.1 24.9)
14.4
12.9
14.6
16.7
(13.7 14.8)
(12.2 13.8)
(12.2 15.7)
(15.6 17.7)
21.7
20.0
21.4
24.0
(21.0 22.3)
(19.0 21.2)
(20.5 22.2)
(23.1 25.4)
34.2
36.3
31.5
33.5
(32.5 36.2)
(34.3 39.4)
(29.9 37.8)
(32.4 35.7)
940
325
267
348
Males
Females
282
248
335
25.2
24.3
26.6
26.8
(23.5 27.1)
(21.7 27.3)
(24.6 28.8)
(25.4 28.3)
15.7
14.1
17.7
19.9
(13.4 17.2)
(12.6 16.7)
(12.3 20.2)
(18.1 20.4)
24.9
23.5
25.5
26.4
(22.8 26.6)
(20.5 27.8)
(24.5 26.5)
(24.7 27.6)
42.1
43.9
42.3
37.0
(35.6 51.2)
(33.7 55.6)
(35.8 73.3)
(35.1 49.3)
375
131
93
151
24.7
23.8
26.4
25.8
(22.2 27.5)
(20.1 28.2)
(24.2 28.9)
(23.6 28.2)
14.9
13.7
17.6
18.7
(13.0 17.2)
(12.1 15.9)
(12.5 20.6)
(10.7 20.5)
24.7
23.9
25.2
25.6
(22.4 26.6)
(19.8 28.8)
(23.8 26.9)
(22.1 27.9)
39.9
36.5
41.6
37.0
(31.9 63.7)
(28.8 56.4)
(34.7 73.3)
(31.3 69.2)
189
25.9
25.1
26.8
27.8
(24.0 28.0)
(21.8 28.8)
(23.1 31.2)
(24.0 32.2)
16.7
14.5
18.3
20.2
(11.4 17.4)
(10.8 17.2)
(8.60 20.6)
(17.8 20.8)
25.1
22.7
25.7
26.9
(22.2 27.7)
(20.1 27.0)
(23.0 28.3)
(22.9 34.5)
45.8
48.8
42.2
36.1
(37.6 55.9)
(37.2 56.6)
(32.9 58.3)
(34.7 51.5)
186
64
45
77
Males
Females
67
48
74
266
266
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
19.2
18.3
19.8
20.5
(18.3 20.1)
(17.0 19.7)
(18.6 21.1)
(19.6 21.3)
12.8
12.2
13.3
14.2
(11.3 13.7)
(10.9 13.1)
(10.5 14.9)
(12.6 15.4)
19.0
17.9
19.2
21.1
(18.1 19.7)
(16.3 19.1)
(17.8 21.1)
(19.7 22.4)
27.8
26.4
28.1
27.5
(25.4 33.8)
(24.5 36.1)
(26.1 34.9)
(25.3 28.2)
310
126
98
86
18.4
17.2
20.0
18.9
(17.3 19.5)
(16.4 18.1)
(17.8 22.3)
(16.7 21.3)
12.3
11.3
13.8
12.4
(10.9 13.3)
(9.43 13.2)
(10.2 15.5)
(8.53 14.5)
17.9
16.4
18.2
19.6
(16.5 19.2)
(16.0 18.2)
(16.8 20.4)
(17.1 21.5)
26.4
25.1
31.9
25.6
(24.3 31.6)
(22.0 48.7)
(26.2 52.2)
(23.5 35.0)
143
19.8
19.3
19.7
21.5
(18.3 21.5)
(17.1 21.8)
(18.0 21.5)
(20.1 23.1)
12.9
12.5
12.9
15.9
(11.2 14.7)
(11.2 14.1)
(8.30 15.4)
(13.1 17.7)
19.4
18.5
19.3
21.9
(18.3 21.6)
(16.8 20.1)
(17.5 22.1)
(19.9 23.2)
28.2
32.1
27.0
27.7
(24.8 40.6)
(24.5 47.8)
(23.6 96.5)
(24.3 40.5)
167
68
56
43
Males
Females
58
42
43
20.9
19.7
20.8
22.7
(20.3 21.5)
(18.9 20.5)
(19.7 21.9)
(21.9 23.5)
14.0
12.8
13.9
16.0
(13.1 14.7)
(11.7 13.6)
(12.7 15.1)
(14.5 16.8)
20.7
19.3
20.8
23.0
(20.1 21.4)
(18.1 20.0)
(19.8 21.8)
(22.0 23.8)
31.0
33.1
30.2
31.9
(29.8 33.3)
(29.5 37.1)
(28.0 32.2)
(29.9 33.5)
990
298
280
412
20.0
18.4
20.5
21.3
(19.3 20.7)
(17.4 19.5)
(19.4 21.6)
(20.4 22.2)
13.7
12.7
14.1
15.4
(12.8 14.8)
(10.9 13.9)
(12.8 15.1)
(12.9 16.7)
19.9
18.3
20.4
21.0
(18.9 20.8)
(17.3 19.4)
(18.7 22.5)
(20.1 22.1)
28.2
25.7
28.2
29.4
(27.1 30.4)
(23.3 29.6)
(27.3 30.6)
(28.0 33.4)
472
21.8
20.9
21.1
23.9
(20.9 22.7)
(19.5 22.5)
(19.7 22.7)
(22.8 25.1)
14.3
12.8
13.8
16.5
(13.2 14.8)
(12.0 13.7)
(11.8 15.4)
(15.0 18.1)
21.5
20.0
21.1
24.1
(20.9 22.2)
(18.5 21.4)
(20.2 22.0)
(23.0 25.5)
33.8
36.9
30.9
33.2
(31.8 36.2)
(34.1 40.4)
(28.2 36.5)
(32.2 35.2)
518
170
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
128
140
204
267
267
268
268
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(140 149)
(147 163)
(148 164)
(139 153)
(152 162)
(154 179)
(128 135)
(146 159)
145
157
166
131
152
(147 156)
145
155
156
151
Non-Hispanic Whites
Non-Hispanic Blacks
Mexican Americans
Race/ethnicity
Males
Females
Gender
4059 years
60 years and older
2039 years
82.2
70.0
76.0
72.8
72.9
71.5
72.0
77.0
73.2
(58.9 89.6)
(52.8 75.7)
(67.7 84.6)
(62.2 76.4)
(67.9 84.9)
(57.7 78.3)
(67.7 86.3)
(62.8 84.0)
(67.9 79.6)
92.0
76.7
88.9
86.1
88.5
84.9
88.3
86.6
87.5
(77.8 101)
(70.3 85.5)
(84.9 92.9)
(76.4 90.0)
(84.7 93.0)
(75.9 91.3)
(83.1 94.0)
(77.7 92.8)
(84.6 89.9)
167
131
152
144
156
139
156
158
151
(153 180)
(127 136)
(144 157)
(135 153)
(150 163)
(135 146)
(147 164)
(148 167)
(145 156)
297
203
261
252
272
251
265
262
262
(260 363)
(196 230)
(250 281)
(237 277)
(261 287)
(239 276)
(258 286)
(254 285)
(254 274)
330
223
287
281
304
281
312
288
289
(295 716)
(206 276)
(275 324)
(260 373)
(287 321)
(262 317)
(284 337)
(275 357)
(281 320)
375
310
991
864
942
609
514
683
1,806
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Selected percentiles (95% conf. interval)
Sample
Geometric mean
2.5th
5th
50th
95th
97.5th
size
( 95% conf. interval)
Mexican Americans
200
300
Overall
100
Females
Males
2039
4059
60+
2039
60+
NonHispanic Whites
100
200
300
NonHispanic Blacks
4059
2039
4059
60+
2039
60+
Males
200
300
Females
4059
100
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma homogammalinolenic
acid (mol/L)
Plasma homogammalinolenic
acid (mol/L)
Plasma homogammalinolenic
acid (mol/L)
Geometric mean (95% confidence interval), National Health and Nutrition Examination Survey, 20032004
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
269
269
151
145
155
156
(147 156)
(140 149)
(147 163)
(148 164)
98.4
95.6
102
100
(95.2 102)
(92.4 99.4)
(94.2 107)
(94.3 104)
151
139
156
158
(145 156)
(135 146)
(147 164)
(148 167)
232
223
240
236
(221 245)
(213 239)
(222 258)
(222 250)
1,806
609
514
683
145
141
153
140
(139 153)
(134 149)
(144 163)
(131 150)
96.7
95.2
101
92.2
(93.1 100)
(88.2 97.7)
(93.8 107)
(84.0 97.9)
144
137
155
141
(135 153)
(131 145)
(141 161)
(133 153)
222
219
232
203
(210 246)
(201 247)
(217 272)
(185 244)
864
282
247
335
157
148
157
170
(152 162)
(142 154)
(148 167)
(162 178)
102
97.3
104
107
(96.6 105)
(91.9 103)
(93.3 107)
(98.4 115)
156
142
157
175
(150 163)
(135 156)
(151 166)
(159 185)
241
226
241
258
(227 258)
(209 270)
(214 264)
(236 274)
942
327
267
348
Males
Females
166
158
178
177
(154 179)
(140 177)
(166 192)
(169 185)
103
96.7
110
119
(90.3 109)
(82.8 104)
(81.4 129)
(108 130)
167
158
178
185
(153 180)
(131 189)
(168 186)
(169 199)
258
254
289
245
(245 293)
(239 295)
(241 360)
(237 261)
375
131
93
151
161
157
171
160
(143 181)
(133 185)
(149 196)
(146 176)
103
102
111
113
(85.0 114)
(65.4 113)
(84.1 132)
(49.9 123)
161
148
168
165
(138 192)
(121 204)
(148 194)
(143 181)
246
248
244
228
(222 296)
(215 329)
(213 361)
(188 288)
189
67
48
74
172
159
188
194
(155 190)
(135 188)
(162 217)
(183 207)
93.0
89.4
106
128
(65.6 109)
(55.8 103)
(65.9 149)
(117 135)
175
160
190
204
(159 201)
(127 200)
(171 214)
(193 214)
272
269
303
258
(240 716)
(225 716)
(244 372)
(238 328)
186
64
45
77
Males
Females
270
270
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
131
129
136
130
(128 135)
(122 136)
(130 143)
(123 136)
91.5
88.0
98.8
85.9
(81.3 96.1)
(72.5 96.0)
(63.0 109)
(75.4 92.8)
131
128
134
134
(127 136)
(117 139)
(128 141)
(117 147)
187
186
198
183
(181 200)
(172 206)
(182 235)
(173 215)
310
126
98
86
125
119
136
120
(119 131)
(111 128)
(129 144)
(107 134)
82.5
77.7
99.7
76.3
(73.7 94.9)
(53.1 94.7)
(71.4 105)
(45.9 90.2)
121
115
128
118
(112 130)
(106 130)
(118 147)
(105 141)
188
174
197
184
(173 203)
(168 196)
(174 261)
(156 213)
143
58
42
43
136
137
136
136
(129 144)
(125 149)
(126 147)
(124 149)
93.0
92.6
94.2
92.6
(85.4 103)
(77.6 104)
(49.0 116)
(70.7 102)
135
134
135
144
(124 150)
(116 159)
(128 145)
(115 160)
186
193
189
182
(180 206)
(174 272)
(156 298)
(171 216)
167
68
56
43
Males
Females
152
147
154
158
(146 159)
(140 154)
(143 165)
(149 167)
99.3
97.2
101
100
(94.2 103)
(91.2 103)
(92.9 107)
(91.9 107)
152
140
156
160
(144 157)
(135 148)
(143 166)
(148 172)
233
226
232
242
(218 250)
(215 245)
(213 261)
(226 256)
991
300
279
412
146
142
152
142
(137 155)
(129 156)
(139 165)
(132 153)
97.0
95.2
100
93.6
(90.8 101)
(73.6 101)
(90.4 107)
(86.9 99.4)
144
136
155
141
(134 155)
(126 147)
(134 165)
(133 154)
222
222
227
206
(206 254)
(187 279)
(210 284)
(184 250)
471
128
139
204
159
151
156
172
(152 165)
(143 160)
(144 169)
(161 184)
104
99.5
103
107
(97.0 106)
(93.5 109)
(86.2 107)
(88.1 124)
157
141
156
177
(150 168)
(135 160)
(149 168)
(161 191)
242
232
240
260
(224 261)
(210 285)
(210 264)
(245 271)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
271
271
272
272
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(716 755)
(772 814)
(798 841)
(744 785)
(769 806)
(678 768)
(839 932)
(752 795)
764
787
722
884
773
(761 791)
735
793
819
776
Non-Hispanic Whites
Non-Hispanic Blacks
Mexican Americans
Race/ethnicity
Males
Females
Gender
4059 years
60 years and older
2039 years
419
526
445
452
429
429
445
448
445
(376 432)
(226 572)
(419 463)
(424 473)
(386 465)
(386 455)
(372 470)
(421 480)
(418 463)
440
576
485
480
490
479
480
502
484
(396 487)
(493 611)
(446 511)
(455 495)
(436 520)
(445 504)
(450 496)
(460 535)
(456 500)
726
883
785
780
792
737
808
841
789
(675 768)
(831 941)
(767 807)
(756 806)
(769 821)
(713 761)
(785 829)
(814 868)
(772 805)
1,110
1,330
1,160
1,150
1,220
1,110
1,220
1,200
1,180
(1,040 1,310)
(1,260 1,580)
(1,120 1,220)
(1,090 1,220)
(1,180 1,300)
(1,050 1,230)
(1,160 1,360)
(1,180 1,260)
(1,150 1,230)
1,290
1,520
1,260
1,230
1,370
1,230
1,380
1,430
1,320
(1,140 1,460)
(1,360 1,770)
(1,190 1,480)
(1,160 1,460)
(1,320 1,460)
(1,140 1,380)
(1,260 1,560)
(1,310 1,490)
(1,240 1,420)
376
310
991
864
943
610
514
683
1,807
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Selected percentiles (95% conf. interval)
Sample
Geometric mean
2.5th
5th
50th
95th
97.5th
size
( 95% conf. interval)
1000
Mexican Americans
500
Females
Males
Plasma arachidonic
acid (mol/L)
1500
Overall
2039
60+
2039
60+
NonHispanic Whites
500
1000
1500
NonHispanic Blacks
4059
Plasma arachidonic
acid (mol/L)
4059
2039
60+
2039
60+
Males
1000
1500
Females
4059
500
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma arachidonic
acid (mol/L)
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
273
273
776
735
793
819
(761 791)
(716 755)
(772 814)
(798 841)
538
529
534
562
(516 560)
(510 542)
(488 569)
(533 591)
789
737
808
841
(772 805)
(713 761)
(785 829)
(814 868)
1,070
1,000
1,090
1,120
(1,040 1,110)
(959 1,080)
(1,050 1,140)
(1,090 1,140)
1,807
610
514
683
764
739
792
761
(744 785)
(710 769)
(761 825)
(726 798)
534
533
529
532
(502 547)
(505 542)
(487 566)
(453 570)
780
736
823
796
(756 806)
(713 766)
(795 842)
(740 839)
1,040
999
1,070
1,030
(1,000 1,090)
(945 1,100)
(1,020 1,150)
(986 1,100)
864
282
247
335
787
732
793
870
(769 806)
(710 755)
(755 833)
(844 896)
549
523
534
620
(517 575)
(497 552)
(464 597)
(551 654)
792
738
787
878
(769 821)
(705 766)
(753 864)
(854 904)
1,100
1,010
1,130
1,150
(1,050 1,160)
(956 1,120)
(1,020 1,230)
(1,120 1,200)
943
328
267
348
Males
Females
722
681
778
811
(678 768)
(631 735)
(718 844)
(777 846)
499
483
510
567
(439 536)
(413 526)
(420 602)
(496 592)
726
687
774
826
(675 768)
(628 745)
(749 835)
(769 874)
1,030
993
1,120
1,170
(975 1,080)
(892 1,070)
(948 1,350)
(1,050 1,330)
376
132
93
151
719
689
770
776
(669 773)
(637 746)
(675 878)
(714 842)
502
503
489
527
(426 535)
(380 540)
(377 606)
(376 590)
745
707
800
811
(674 788)
(609 758)
(748 843)
(643 924)
1,030
983
1,040
1,090
(937 1,090)
(851 1,110)
(881 1,460)
(1,000 1,360)
189
67
48
74
724
670
788
844
(659 796)
(591 760)
(711 874)
(790 902)
479
436
567
586
(352 582)
(352 539)
(447 616)
(580 600)
716
676
756
835
(653 782)
(626 723)
(652 885)
(810 873)
1,020
987
1,250
1,220
(945 1,310)
(856 1,310)
(964 1,430)
(987 1,940)
187
65
45
77
Males
Females
274
274
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
884
836
936
919
(839 932)
(776 901)
(858 1,020)
(859 983)
630
602
681
714
(588 670)
(542 635)
(513 711)
(534 744)
883
839
942
933
(831 941)
(769 887)
(827 1,040)
(830 1,030)
1,220
1,210
1,230
1,200
(1,160 1,330)
(1,040 1,380)
(1,170 1,760)
(1,160 1,330)
310
126
98
86
870
811
953
886
(817 925)
(737 892)
(875 1,040)
(774 1,010)
591
580
666
535
(512 659)
(479 616)
(501 727)
(226 722)
859
812
984
940
(811 976)
(692 891)
(780 1,070)
(833 1,050)
1,200
1,120
1,230
1,180
(1,130 1,330)
(1,020 1,660)
(1,110 2,240)
(1,130 1,440)
143
58
42
43
895
858
923
940
(829 967)
(773 952)
(818 1,040)
(889 995)
648
616
679
740
(588 704)
(570 661)
(468 714)
(715 762)
884
857
912
916
(823 958)
(746 955)
(824 1,020)
(809 1,040)
1,230
1,230
1,230
1,220
(1,130 1,470)
(1,010 1,390)
(1,100 2,020)
(1,130 1,490)
167
68
56
43
Males
Females
773
733
782
815
(752 795)
(711 755)
(749 817)
(788 843)
539
533
531
562
(497 569)
(490 569)
(465 579)
(504 604)
785
736
800
839
(767 807)
(706 766)
(777 830)
(811 870)
1,050
971
1,040
1,110
(1,010 1,100)
(929 1,060)
(1,010 1,120)
(1,070 1,140)
991
300
279
412
760
731
789
752
(733 788)
(702 762)
(748 832)
(711 795)
534
527
539
524
(488 558)
(480 562)
(476 569)
(444 573)
783
735
823
769
(752 810)
(698 771)
(786 863)
(715 833)
1,000
957
1,030
998
(981 1,050)
(899 1,160)
(997 1,160)
(962 1,110)
471
128
139
204
785
733
776
873
(761 811)
(701 768)
(722 835)
(841 905)
552
532
530
610
(500 583)
(432 583)
(403 598)
(541 665)
786
738
780
889
(769 816)
(699 768)
(726 858)
(857 916)
1,080
997
1,060
1,150
(1,040 1,160)
(920 1,150)
(991 1,240)
(1,120 1,200)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
275
275
276
276
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
31.0
38.8
43.5
43.1
41.3
35.9
45.5
48.5
42.1
(28.7 33.5)
(34.7 43.4)
(39.8 47.7)
(39.8 46.6)
(38.7 44.1)
(33.8 38.1)
(41.8 49.5)
(43.3 54.4)
(39.5 45.0)
Non-Hispanic Whites
Mexican Americans
Non-Hispanic Blacks
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
8.80
14.9
15.8
15.7
14.1
13.5
17.1
15.3
14.8
(6.03 10.9)
(10.8 16.1)
(11.6 17.3)
(11.2 16.9)
(11.2 15.7)
(9.10 14.9)
(14.6 17.4)
(7.79 19.9)
(11.8 16.1)
10.9
16.7
18.1
17.1
16.9
15.8
19.0
20.0
17.1
(7.53 15.3)
(14.4 18.8)
(14.9 20.8)
(15.5 20.1)
(15.2 18.3)
(13.6 16.8)
(17.1 20.8)
(11.8 23.1)
(15.7 18.6)
31.4
36.1
42.6
41.4
40.1
34.2
45.0
49.4
40.9
(28.4 35.4)
(33.0 41.6)
(38.1 46.0)
(37.6 45.1)
(37.5 43.1)
(32.0 36.2)
(41.0 48.3)
(43.5 53.8)
(37.6 43.8)
77.1
113
112
121
111
106
114
132
113
(69.0 86.4)
(95.3 169)
(101 142)
(103 150)
(99.9 143)
(84.3 137)
(102 153)
(111 162)
(103 138)
86.5
141
152
156
146
134
156
175
151
(79.1 98.9)
(114 247)
(133 177)
(136 199)
(118 177)
(110 193)
(134 200)
(139 207)
(136 176)
375
310
991
863
943
609
515
682
1,806
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Selected percentiles (95% conf. interval)
Sample
Geometric mean
2.5th
5th
50th
95th
97.5th
size
( 95% conf. interval)
Mexican Americans
60
20
40
Females
Males
Plasma eicosapentaenoic
acid (mol/L)
80
Overall
2039
4059
60+
2039
NonHispanic Blacks
4059
60+
60
40
20
0
Plasma eicosapentaenoic
acid (mol/L)
80
NonHispanic Whites
2039
4059
60+
2039
60+
Males
60
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma eicosapentaenoic
acid (mol/L)
80
Females
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
277
277
42.1
35.9
45.5
48.5
(39.5 45.0)
(33.8 38.1)
(41.8 49.5)
(43.3 54.4)
20.8
18.2
22.8
24.4
(18.9 22.2)
(16.7 20.2)
(19.4 26.2)
(15.6 29.1)
40.9
34.2
45.0
49.4
(37.6 43.8)
(32.0 36.2)
(41.0 48.3)
(43.5 53.8)
89.9
74.5
92.8
100
(80.0 99.9)
(64.8 94.2)
(81.5 103)
(90.6 116)
1,806
609
515
682
43.1
38.7
47.3
44.2
(39.8 46.6)
(35.6 42.0)
(42.5 52.7)
(38.7 50.5)
21.0
18.7
23.4
22.1
(18.5 23.0)
(16.8 20.6)
(20.8 26.6)
(10.4 27.5)
41.4
36.1
45.7
44.6
(37.6 45.1)
(34.3 40.5)
(40.0 48.9)
(38.7 51.3)
92.8
86.1
97.4
88.7
(81.4 104)
(70.8 108)
(82.2 136)
(74.8 109)
863
281
248
334
41.3
33.3
43.9
52.4
(38.7 44.1)
(30.9 36.0)
(40.1 48.1)
(47.2 58.1)
20.4
17.4
21.9
25.2
(18.5 22.2)
(15.8 19.8)
(17.2 27.5)
(21.5 29.7)
40.1
31.4
43.4
51.7
(37.5 43.1)
(30.1 34.1)
(40.3 47.8)
(49.2 57.1)
86.3
64.6
84.6
105
(76.6 101)
(56.5 80.8)
(76.6 100)
(94.5 134)
943
328
267
348
Males
Females
31.0
28.0
35.5
38.2
(28.7 33.5)
(24.9 31.4)
(30.7 41.0)
(35.8 40.7)
15.8
15.4
17.0
17.9
(11.1 18.4)
(8.96 18.3)
(12.2 19.0)
(12.9 21.6)
31.4
28.3
35.9
40.5
(28.4 35.4)
(21.7 35.1)
(31.0 40.8)
(34.3 43.5)
63.8
59.1
76.2
72.9
(58.1 70.0)
(50.9 68.1)
(56.8 91.5)
(61.1 95.6)
375
132
93
150
33.1
30.6
39.3
33.6
(29.9 36.8)
(25.4 36.8)
(31.6 48.8)
(29.9 37.8)
16.4
16.1
16.2
16.0
(15.5 18.4)
(9.95 18.9)
(11.8 22.3)
(12.8 18.3)
34.3
29.4
37.6
34.4
(29.0 37.9)
(22.2 40.7)
(30.0 51.3)
(24.2 43.5)
68.9
63.9
82.2
56.5
(60.4 77.9)
(50.2 78.0)
(66.1 180)
(48.9 161)
188
67
48
73
28.6
24.8
31.6
42.9
(24.9 32.8)
(20.1 30.7)
(27.4 36.4)
(36.7 50.1)
13.8
10.8
17.1
22.2
(7.13 18.3)
(6.03 18.2)
(8.81 19.8)
(8.91 26.3)
29.1
23.5
31.3
43.3
(23.4 35.1)
(19.9 31.6)
(26.8 37.9)
(38.1 49.3)
60.2
53.1
55.9
85.0
(49.1 76.5)
(39.3 90.1)
(46.3 84.0)
(63.7 147)
187
65
45
77
Males
Females
278
278
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
38.8
33.9
42.9
46.0
(34.7 43.4)
(28.3 40.8)
(37.2 49.6)
(39.2 53.9)
19.9
17.9
20.8
27.2
(17.5 21.2)
(15.0 20.1)
(16.4 24.8)
(19.4 30.4)
36.1
32.6
39.9
44.5
(33.0 41.6)
(25.1 40.6)
(35.3 44.2)
(36.2 51.1)
80.3
64.8
96.3
88.6
(64.8 121)
(53.4 253)
(72.1 147)
(64.3 209)
310
126
98
86
39.9
34.9
44.4
48.4
(34.4 46.2)
(26.9 45.3)
(37.5 52.5)
(34.5 67.7)
18.9
16.6
21.0
26.1
(15.3 22.2)
(12.9 19.5)
(17.3 26.5)
(7.52 32.4)
35.5
33.3
36.0
44.4
(32.4 41.6)
(24.6 43.0)
(30.8 50.1)
(35.0 59.2)
106
64.8
117
102
(70.6 134)
(51.9 150)
(79.5 206)
(61.1 209)
143
58
42
43
38.0
33.2
41.8
44.5
(34.0 42.4)
(27.9 39.5)
(34.9 50.2)
(39.7 50.0)
20.1
18.6
19.8
25.5
(18.5 21.4)
(13.2 20.4)
(12.6 25.5)
(20.0 30.5)
36.2
29.7
41.3
44.1
(30.4 43.9)
(25.6 35.7)
(35.8 46.4)
(35.2 51.1)
71.2
64.3
71.2
75.9
(61.3 105)
(44.7 253)
(64.0 193)
(62.8 104)
167
68
56
43
Males
Females
43.5
37.5
45.8
49.0
(39.8 47.7)
(34.3 41.0)
(41.5 50.6)
(42.5 56.5)
21.9
20.4
23.9
23.5
(18.6 24.7)
(16.3 21.9)
(18.8 27.7)
(11.7 29.6)
42.6
35.3
45.2
49.9
(38.1 46.0)
(32.0 38.3)
(40.5 48.7)
(44.2 54.8)
90.5
74.7
89.0
101
(78.4 102)
(63.8 110)
(78.7 101)
(91.7 117)
991
299
280
412
44.3
40.1
48.0
44.3
(40.1 48.9)
(35.9 44.7)
(42.2 54.6)
(38.0 51.6)
21.9
20.6
25.1
21.8
(17.3 25.8)
(16.9 22.7)
(20.7 27.5)
(10.3 28.6)
43.1
37.8
47.3
44.8
(37.6 47.6)
(34.8 42.9)
(40.0 50.2)
(37.6 52.3)
89.8
89.0
92.4
87.2
(78.2 105)
(67.8 119)
(80.9 140)
(75.6 105)
471
127
140
204
42.9
35.4
43.8
53.5
(39.0 47.2)
(31.7 39.4)
(39.1 48.9)
(46.4 61.6)
21.8
18.2
22.3
24.6
(18.3 24.6)
(15.8 21.9)
(12.3 30.0)
(18.7 30.9)
42.0
31.9
43.3
53.5
(37.9 45.6)
(30.2 37.0)
(37.8 48.4)
(49.3 59.7)
91.3
68.2
81.0
110
(76.7 104)
(54.3 112)
(74.2 100)
(96.5 138)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
279
279
280
280
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
27.5
26.0
24.8
25.3
24.7
24.4
25.5
25.3
25.0
(25.6 29.5)
(25.1 26.8)
(23.9 25.6)
(24.4 26.2)
(24.0 25.5)
(23.4 25.4)
(24.5 26.4)
(24.6 26.0)
(24.4 25.6)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
13.1
13.4
12.1
11.8
12.2
12.2
11.2
12.6
12.1
(11.2 15.6)
(9.11 15.0)
(10.0 13.5)
(9.72 13.1)
(9.93 13.9)
(10.4 13.8)
(9.62 12.9)
(9.34 14.4)
(10.4 13.1)
15.8
15.0
14.5
14.5
14.3
14.3
14.3
14.8
14.4
(12.9 16.6)
(13.2 16.7)
(13.0 15.1)
(13.5 14.9)
(13.0 15.1)
(13.1 15.0)
(12.0 15.4)
(12.9 15.8)
(13.3 14.9)
27.4
25.8
24.6
25.0
24.5
23.9
25.0
25.7
24.7
(25.1 29.6)
(24.3 26.8)
(23.9 25.6)
(24.3 26.1)
(23.6 25.6)
(23.1 24.9)
(24.3 26.6)
(24.5 26.6)
(24.1 25.6)
43.0
(41.6 44.7)
47.7
(45.4 53.5)
47.3
45.0
41.9
42.4
43.7
41.1
44.5
42.2
(45.9 53.3)
(42.0 46.7)
(39.6 44.7)
(41.0 44.9)
(41.4 45.9)
(38.8 46.0)
(42.1 46.2)
(39.6 45.3)
58.5
50.4
47.2
46.8
48.0
47.1
50.0
47.1
(48.0 66.9)
(46.1 72.9)
(44.5 56.1)
(44.6 58.2)
(44.8 56.3)
(42.8 58.0)
(45.0 63.4)
(44.7 49.5)
376
310
992
865
943
610
515
683
1,808
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
40
Mexican Americans
10
20
30
Females
Males
Plasma docosatetraenoic
acid (mol/L)
Overall
2039
4059
60+
2039
20
30
40
NonHispanic Whites
10
2039
4059
60+
2039
4059
60+
Males
40
Females
10
20
30
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma docosatetraenoic
acid (mol/L)
60+
Plasma docosatetraenoic
acid (mol/L)
NonHispanic Blacks
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
281
281
25.0
24.4
25.5
25.3
(24.4 25.6)
(23.4 25.4)
(24.5 26.4)
(24.6 26.0)
16.8
16.7
17.0
16.7
(15.7 17.4)
(15.0 17.5)
(14.8 18.0)
(16.0 17.5)
24.7
23.9
25.0
25.7
(24.1 25.6)
(23.1 24.9)
(24.3 26.6)
(24.5 26.6)
37.7
37.1
39.4
37.0
(36.7 39.4)
(34.7 39.1)
(37.4 41.6)
(36.3 38.3)
1,808
610
515
683
25.3
25.2
26.1
24.1
(24.4 26.2)
(23.8 26.6)
(24.9 27.3)
(22.9 25.3)
16.9
17.1
17.3
16.0
(15.8 18.0)
(14.8 18.7)
(14.7 19.5)
(14.8 16.8)
25.0
24.5
25.9
24.3
(24.3 26.1)
(23.6 26.1)
(24.5 27.9)
(22.5 26.5)
38.2
38.3
39.8
35.9
(36.5 40.0)
(35.5 40.8)
(36.8 43.7)
(34.2 37.6)
865
282
248
335
24.7
23.6
24.9
26.3
(24.0 25.5)
(22.5 24.8)
(23.4 26.5)
(25.1 27.6)
16.5
15.8
15.6
17.6
(15.4 17.4)
(14.4 17.1)
(14.5 17.5)
(16.4 18.5)
24.5
23.1
24.6
26.2
(23.6 25.6)
(21.3 24.7)
(23.4 26.4)
(24.9 27.8)
37.5
35.9
38.3
38.3
(36.0 40.6)
(32.7 38.8)
(35.3 43.3)
(36.3 43.9)
943
328
267
348
Males
Females
27.5
26.3
29.1
30.5
(25.6 29.5)
(24.0 28.8)
(26.8 31.6)
(29.3 31.8)
17.9
16.4
18.2
20.6
(15.5 19.6)
(12.1 19.5)
(13.2 20.2)
(17.6 22.4)
27.4
26.1
28.4
30.2
(25.1 29.6)
(21.9 29.9)
(26.2 31.2)
(28.3 32.1)
43.1
41.1
45.6
43.6
(40.6 46.6)
(36.6 47.8)
(42.2 59.9)
(40.4 48.5)
376
132
93
151
27.7
26.9
29.1
29.4
(25.0 30.8)
(23.6 30.6)
(24.5 34.6)
(26.2 32.9)
18.4
18.5
17.9
18.8
(13.6 20.3)
(12.6 20.7)
(13.8 21.3)
(17.0 21.2)
27.3
26.2
28.3
28.5
(24.4 31.1)
(22.5 29.9)
(25.3 33.8)
(24.6 34.1)
41.5
40.4
44.6
45.0
(39.1 48.7)
(36.1 58.6)
(37.0 63.5)
(37.4 67.2)
189
67
48
74
27.2
25.5
29.0
31.6
(24.6 30.1)
(22.2 29.2)
(25.6 32.9)
(30.2 33.1)
16.9
15.6
18.5
20.8
(11.4 19.7)
(11.2 18.0)
(13.2 21.6)
(17.8 25.8)
27.6
25.1
27.2
31.1
(23.8 30.3)
(20.0 32.3)
(23.7 31.6)
(29.8 33.2)
43.5
42.9
45.8
41.7
(40.3 50.5)
(34.4 58.4)
(42.0 61.3)
(36.9 66.9)
187
65
45
77
Males
Females
282
282
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
26.0
25.3
27.2
25.6
(25.1 26.8)
(24.1 26.4)
(25.0 29.5)
(22.9 28.6)
17.4
17.5
17.4
16.8
(15.5 18.7)
(14.8 18.9)
(14.3 19.8)
(9.11 20.5)
25.8
24.0
26.7
25.8
(24.3 26.8)
(22.6 26.3)
(24.7 28.2)
(24.0 29.4)
38.6
37.8
41.1
35.7
(37.0 41.1)
(34.6 44.2)
(38.8 46.3)
(33.3 40.3)
310
126
98
86
26.7
25.7
28.6
25.6
(24.6 28.9)
(24.1 27.5)
(24.8 33.0)
(20.3 32.3)
17.5
17.5
18.0
15.3
(13.0 19.5)
(11.3 19.7)
(12.7 20.7)
(9.11 23.9)
25.8
23.8
26.9
26.0
(23.0 29.1)
(21.7 27.5)
(23.7 30.4)
(24.1 31.6)
41.6
39.9
41.9
37.0
(38.0 46.0)
(34.0 75.9)
(36.6 96.8)
(32.0 47.5)
143
58
42
43
25.4
24.9
26.1
25.6
(24.0 27.0)
(23.1 26.8)
(22.7 30.1)
(23.6 27.6)
17.3
17.5
15.6
17.5
(15.1 18.7)
(13.4 19.2)
(13.4 20.0)
(13.4 21.3)
25.6
24.5
26.6
25.1
(23.6 27.2)
(22.3 27.7)
(22.7 27.9)
(23.5 27.4)
36.4
35.9
39.1
35.5
(34.4 40.4)
(30.8 46.3)
(31.1 118)
(32.5 36.6)
167
68
56
43
Males
Females
24.8
24.1
25.0
25.2
(23.9 25.6)
(22.8 25.6)
(23.5 26.6)
(24.3 26.0)
16.8
16.4
17.2
16.6
(15.6 17.5)
(14.6 17.6)
(14.5 18.6)
(15.6 17.4)
24.6
23.8
24.7
25.6
(23.9 25.6)
(22.9 24.9)
(23.6 26.5)
(24.1 27.0)
36.8
35.5
36.8
36.9
(35.3 37.9)
(32.1 39.6)
(34.8 41.3)
(36.3 38.2)
992
300
280
412
24.9
24.8
25.8
23.9
(23.8 26.1)
(22.9 26.7)
(24.1 27.5)
(22.5 25.4)
16.9
17.0
17.8
15.9
(15.0 18.1)
(12.5 18.9)
(10.9 19.8)
(14.5 16.8)
24.7
24.3
25.2
24.1
(24.0 26.1)
(23.3 26.1)
(24.4 27.9)
(22.1 26.6)
36.7
36.3
36.9
34.9
(35.1 38.3)
(33.0 39.7)
(35.2 44.0)
(33.5 37.2)
472
128
140
204
24.6
23.6
24.4
26.3
(23.7 25.6)
(21.9 25.4)
(22.4 26.6)
(25.0 27.6)
16.6
15.8
15.9
17.3
(15.4 17.4)
(14.3 17.2)
(13.7 18.0)
(16.5 18.0)
24.4
23.0
24.3
26.2
(23.5 25.6)
(21.0 25.1)
(22.5 25.9)
(24.7 28.1)
36.9
34.6
35.5
38.7
(34.4 41.0)
(31.9 45.6)
(32.9 44.5)
(36.3 44.4)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
283
283
284
284
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
39.9
38.9
42.1
42.8
40.5
38.1
43.1
45.5
41.6
(37.2 42.9)
(36.8 41.0)
(40.1 44.1)
(41.0 44.8)
(39.1 42.0)
(37.1 39.0)
(41.1 45.3)
(42.3 48.8)
(40.2 43.1)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
16.9
20.1
22.8
24.2
20.5
20.0
22.2
24.5
22.1
(12.1 22.3)
(17.5 21.5)
(15.6 24.2)
(15.0 25.6)
(13.6 22.8)
(15.1 22.7)
(13.5 24.3)
(11.7 26.7)
(17.2 23.8)
22.4
22.3
24.7
26.2
23.1
23.2
24.9
26.5
24.5
(14.1 25.0)
(20.6 23.8)
(22.5 26.7)
(24.7 27.1)
(20.7 24.5)
(20.9 24.4)
(20.6 26.9)
(23.6 28.5)
(22.8 25.8)
40.0
38.1
42.2
42.5
40.6
38.0
43.2
45.7
41.4
(36.4 44.1)
(36.2 40.0)
(40.4 43.8)
(40.6 44.1)
(38.8 42.0)
(36.8 39.3)
(40.6 46.0)
(42.8 49.1)
(40.0 42.8)
72.7
(69.7 76.7)
82.9
(78.5 92.2)
71.5
64.5
71.7
72.7
72.7
63.0
77.0
74.0
(67.8 79.3)
(62.0 80.1)
(67.9 78.5)
(68.1 81.6)
(67.8 78.6)
(58.0 73.3)
(72.6 81.0)
(70.7 81.9)
80.9
85.0
81.2
87.2
80.4
73.0
84.9
82.0
(72.5 112)
(67.0 108)
(75.5 92.7)
(78.7 97.2)
(75.5 89.8)
(65.5 95.1)
(79.4 105)
(76.6 97.8)
376
310
992
865
943
610
515
683
1,808
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
60
Mexican Americans
20
40
Females
Males
Plasma docosapentaenoic3
acid (mol/L)
Overall
2039
4059
60+
2039
20
40
60
NonHispanic Whites
2039
4059
60+
2039
4059
60+
Males
60
Females
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma docosapentaenoic3
acid (mol/L)
60+
Plasma docosapentaenoic3
acid (mol/L)
NonHispanic Blacks
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
285
285
41.6
38.1
43.1
45.5
(40.2 43.1)
(37.1 39.0)
(41.1 45.3)
(42.3 48.8)
27.4
26.1
27.6
29.6
(26.2 28.4)
(24.8 26.7)
(26.0 29.8)
(25.8 33.7)
41.4
38.0
43.2
45.7
(40.0 42.8)
(36.8 39.3)
(40.6 46.0)
(42.8 49.1)
62.3
54.8
65.2
67.6
(60.4 65.4)
(52.4 59.9)
(61.6 69.7)
(63.0 72.4)
1,808
610
515
683
42.8
40.8
44.9
43.1
(41.0 44.8)
(39.1 42.6)
(41.9 48.0)
(39.2 47.4)
28.8
27.3
30.2
28.7
(26.9 30.4)
(25.6 29.1)
(28.4 31.6)
(23.4 33.1)
42.5
40.5
44.2
42.9
(40.6 44.1)
(38.5 42.9)
(40.7 47.8)
(40.9 47.2)
63.7
59.1
68.0
60.3
(60.0 68.0)
(54.0 66.2)
(63.3 77.9)
(58.1 66.1)
865
282
248
335
40.5
35.6
41.6
47.5
(39.1 42.0)
(34.4 36.7)
(39.3 44.1)
(44.8 50.3)
26.2
23.9
26.1
30.0
(24.8 27.4)
(22.8 25.7)
(23.1 27.7)
(26.8 34.2)
40.6
35.8
41.9
48.0
(38.8 42.0)
(34.2 37.7)
(39.3 44.7)
(44.5 50.6)
61.4
50.4
61.2
70.1
(59.9 65.0)
(48.4 56.6)
(58.6 71.2)
(67.7 74.5)
943
328
267
348
Males
Females
39.9
36.9
44.5
46.5
(37.2 42.9)
(33.4 40.7)
(39.4 50.3)
(45.2 47.9)
25.9
24.4
27.8
30.5
(20.2 29.5)
(15.2 27.2)
(25.5 30.9)
(25.7 35.6)
40.0
36.8
44.9
46.6
(36.4 44.1)
(34.2 39.9)
(39.4 48.2)
(44.5 50.8)
61.2
54.9
69.4
67.4
(57.8 67.9)
(50.1 75.1)
(58.3 127)
(57.5 80.9)
376
132
93
151
41.6
38.9
47.3
44.3
(37.6 46.0)
(34.0 44.4)
(37.9 59.0)
(40.8 48.0)
26.8
25.4
29.4
27.9
(22.1 30.9)
(15.2 30.7)
(26.2 31.9)
(20.5 32.2)
40.5
37.2
46.6
46.4
(36.3 46.4)
(35.5 40.8)
(33.3 60.1)
(40.6 50.0)
67.4
60.5
76.8
63.3
(59.1 74.5)
(52.3 73.1)
(55.8 127)
(55.2 83.1)
189
67
48
74
38.0
34.3
41.6
48.7
(34.6 41.6)
(29.6 39.9)
(38.4 45.0)
(45.6 52.0)
24.3
20.0
25.9
31.5
(13.1 29.6)
(12.1 28.3)
(17.2 32.5)
(27.6 39.2)
39.2
35.3
41.5
50.2
(34.1 44.9)
(30.6 41.1)
(36.9 47.2)
(44.4 52.9)
57.5
50.6
60.2
69.2
(52.2 60.8)
(47.1 85.4)
(55.9 74.8)
(57.4 90.2)
187
65
45
77
Males
Females
286
286
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
38.9
36.0
41.1
43.0
(36.8 41.0)
(32.7 39.5)
(37.4 45.2)
(40.4 45.8)
25.6
24.3
26.6
30.5
(24.6 26.5)
(21.5 25.8)
(24.3 28.0)
(21.3 34.2)
38.1
35.2
40.0
43.0
(36.2 40.0)
(32.0 38.1)
(35.2 44.2)
(39.5 47.7)
59.3
54.6
60.3
60.6
(55.1 62.4)
(48.6 63.5)
(57.2 84.5)
(54.6 63.6)
310
126
98
86
40.8
38.1
43.4
44.4
(38.5 43.2)
(33.8 43.0)
(41.7 45.1)
(41.1 48.0)
26.1
25.3
28.4
31.7
(24.7 29.2)
(20.3 28.5)
(24.7 30.5)
(17.8 36.7)
38.7
37.7
40.3
44.9
(37.7 41.4)
(32.3 39.9)
(38.6 42.1)
(40.9 50.5)
60.2
59.8
68.5
60.5
(58.8 69.2)
(44.2 131)
(57.2 108)
(58.2 64.6)
143
58
42
43
37.4
34.3
39.5
42.2
(35.0 40.1)
(31.2 37.7)
(33.5 46.5)
(39.0 45.7)
24.4
21.9
23.9
29.5
(22.4 26.2)
(18.8 25.8)
(20.6 27.1)
(25.6 34.3)
36.8
33.5
39.3
41.7
(34.3 40.1)
(28.9 38.8)
(33.9 44.8)
(37.8 47.7)
54.4
53.0
58.0
56.6
(51.8 62.5)
(45.4 64.5)
(48.6 148)
(52.5 70.1)
167
68
56
43
Males
Females
42.1
38.8
42.8
45.6
(40.1 44.1)
(37.5 40.2)
(40.1 45.7)
(41.8 49.8)
27.7
26.7
27.6
29.5
(26.1 29.0)
(24.8 28.1)
(24.8 30.1)
(25.0 33.7)
42.2
38.8
43.3
45.8
(40.4 43.8)
(36.8 41.0)
(39.7 47.0)
(42.5 50.1)
62.8
54.7
63.6
68.0
(60.0 67.4)
(52.1 61.5)
(60.8 68.0)
(64.1 73.0)
992
300
280
412
43.1
41.5
44.5
43.0
(40.7 45.6)
(39.4 43.6)
(41.1 48.2)
(38.4 48.1)
29.2
27.5
30.8
29.5
(26.9 31.2)
(26.4 29.3)
(27.1 32.2)
(14.9 33.9)
43.1
42.3
44.2
42.7
(40.6 45.3)
(39.1 44.4)
(39.7 48.3)
(39.7 47.5)
63.0
56.4
66.1
60.2
(59.6 66.9)
(53.0 72.1)
(61.6 75.0)
(57.3 70.0)
472
128
140
204
41.2
36.6
41.1
48.0
(39.3 43.1)
(34.7 38.6)
(38.0 44.6)
(44.4 51.8)
26.5
24.8
26.0
29.5
(24.5 28.2)
(22.8 28.3)
(22.3 27.7)
(24.8 34.5)
41.3
36.8
42.0
48.4
(38.8 43.0)
(34.2 38.5)
(38.8 46.6)
(44.1 52.6)
62.4
50.0
60.1
72.4
(59.2 71.1)
(46.5 61.2)
(57.1 73.0)
(68.4 75.1)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
287
287
288
288
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
23.5
21.3
19.1
18.6
20.6
19.5
19.4
20.3
19.6
(21.0 26.2)
(20.3 22.4)
(18.3 19.9)
(17.7 19.7)
(19.8 21.4)
(18.6 20.5)
(18.4 20.4)
(19.5 21.2)
(18.9 20.4)
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
2039 years
4059 years
60 years and older
10.4
9.27
8.15
8.11
8.92
9.15
8.37
8.00
8.56
(6.86 11.5)
(5.89 10.3)
(7.49 9.20)
(6.96 9.23)
(7.74 9.55)
(8.17 9.51)
(4.40 9.67)
(5.88 8.84)
(7.60 9.46)
11.6
10.2
9.67
9.66
9.95
9.88
9.80
9.63
9.80
(8.94 13.5)
(9.35 11.6)
(8.52 10.6)
(8.83 10.4)
(9.30 11.2)
(9.25 11.1)
(7.79 11.1)
(8.26 10.8)
(9.30 10.5)
22.8
20.8
18.9
18.6
20.5
18.8
19.0
20.5
19.3
(19.7 27.1)
(19.7 22.4)
(18.3 19.8)
(17.8 19.3)
(19.2 21.7)
(17.9 20.0)
(18.3 20.5)
(19.5 21.5)
(18.6 20.1)
39.0
(36.1 42.4)
46.5
(42.9 52.2)
47.6
43.0
36.0
34.6
41.9
41.4
36.0
41.4
(44.2 56.0)
(40.4 50.4)
(34.0 40.9)
(32.2 40.5)
(38.5 47.8)
(35.5 46.3)
(34.5 39.1)
(37.9 48.4)
53.6
50.6
45.2
42.8
50.6
47.8
41.6
52.1
(48.5 60.2)
(45.0 63.2)
(40.7 51.4)
(38.6 45.2)
(46.4 59.0)
(45.1 54.4)
(37.2 50.8)
(46.8 58.0)
376
310
992
865
943
610
515
683
1,808
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Geometric mean
Sample
Selected percentiles (95% conf. interval)
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
40
Mexican Americans
10
20
30
Females
Males
Plasma docosapentaenoic6
acid (mol/L)
Overall
2039
4059
60+
2039
10
20
30
40
NonHispanic Whites
2039
4059
60+
2039
4059
60+
Males
40
Females
10
20
30
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma docosapentaenoic6
acid (mol/L)
60+
Plasma docosapentaenoic6
acid (mol/L)
NonHispanic Blacks
4059
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water
Vitamins
-Soluble
& Nutr
Vitamins
ients
289
289
19.6
19.5
19.4
20.3
(18.9 20.4)
(18.6 20.5)
(18.4 20.4)
(19.5 21.2)
11.8
11.8
11.5
12.2
(11.4 12.3)
(11.2 12.9)
(11.2 12.1)
(10.6 12.8)
19.3
18.8
19.0
20.5
(18.6 20.1)
(17.9 20.0)
(18.3 20.5)
(19.5 21.5)
32.5
32.4
31.8
33.2
(31.4 33.9)
(31.3 34.8)
(29.8 34.2)
(31.2 38.6)
1,808
610
515
683
18.6
18.4
19.0
18.4
(17.7 19.7)
(17.3 19.6)
(17.7 20.3)
(17.2 19.7)
11.7
12.1
11.8
10.4
(11.0 12.3)
(10.8 13.1)
(10.6 12.4)
(9.64 11.7)
18.6
18.0
19.0
18.7
(17.8 19.3)
(17.1 18.7)
(17.6 20.7)
(17.7 20.0)
29.8
29.6
29.4
31.2
(28.8 32.1)
(27.2 33.4)
(28.1 33.3)
(27.9 35.6)
865
282
248
335
20.6
20.6
19.8
22.0
(19.8 21.4)
(19.4 21.9)
(18.3 21.3)
(20.7 23.3)
12.0
11.6
11.3
13.7
(11.3 12.7)
(9.88 13.0)
(10.7 12.1)
(12.4 14.4)
20.5
20.5
19.1
22.0
(19.2 21.7)
(18.7 22.2)
(17.8 21.7)
(20.7 23.1)
34.5
35.0
34.3
35.5
(33.0 36.6)
(32.4 41.2)
(31.1 36.4)
(31.4 48.5)
943
328
267
348
Males
Females
23.5
22.0
24.9
28.5
(21.0 26.2)
(19.6 24.8)
(21.6 28.7)
(24.4 33.3)
14.1
13.2
14.2
17.8
(11.5 15.0)
(9.09 14.9)
(8.50 16.5)
(15.1 19.7)
22.8
21.0
24.7
28.2
(19.7 27.1)
(18.0 25.7)
(20.6 29.6)
(23.4 33.9)
42.8
40.8
43.8
45.1
(38.9 46.1)
(33.5 45.8)
(38.4 52.6)
(36.8 71.9)
376
132
93
151
22.4
21.1
24.1
26.7
(19.8 25.4)
(18.5 24.1)
(19.7 29.6)
(22.9 31.2)
13.7
13.3
13.8
16.4
(10.4 15.7)
(9.51 15.4)
(6.48 17.7)
(12.7 19.2)
21.2
19.8
24.5
26.1
(19.1 26.0)
(17.6 23.2)
(18.1 33.3)
(20.7 33.2)
38.7
33.4
42.5
41.8
(34.0 44.6)
(29.0 51.2)
(31.7 52.7)
(35.3 56.1)
189
67
48
74
24.8
23.4
25.8
30.3
(21.5 28.7)
(19.3 28.2)
(20.4 32.6)
(23.9 38.3)
14.1
12.0
14.4
19.5
(9.21 15.0)
(8.52 14.8)
(10.5 16.8)
(14.3 21.0)
24.5
22.1
24.6
28.8
(20.1 31.4)
(15.0 32.1)
(18.0 35.8)
(22.4 41.5)
44.7
45.5
43.5
48.8
(41.4 53.8)
(35.2 104)
(37.4 70.9)
(37.9 71.9)
187
65
45
77
Males
Females
290
290
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
21.3
21.0
21.5
22.1
(20.3 22.4)
(19.2 22.8)
(19.4 23.7)
(18.4 26.6)
12.4
12.8
12.1
12.8
(10.4 13.5)
(11.7 13.4)
(9.42 13.5)
(5.89 14.9)
20.8
19.9
21.7
22.9
(19.7 22.4)
(18.3 23.5)
(19.7 22.6)
(17.6 28.4)
35.3
34.8
34.9
37.7
(33.3 41.5)
(31.5 50.8)
(30.5 44.0)
(32.6 45.7)
310
126
98
86
20.0
18.8
21.4
21.1
(18.1 22.2)
(17.2 20.6)
(18.2 25.1)
(15.6 28.7)
11.7
11.4
12.2
9.26
(9.26 13.2)
(5.94 13.4)
(9.72 13.8)
(5.89 15.5)
19.8
18.9
21.7
21.5
(18.3 21.6)
(15.9 19.9)
(18.1 23.2)
(16.0 31.7)
34.8
32.8
32.9
39.9
(30.9 43.6)
(27.6 47.8)
(27.0 89.5)
(32.2 50.3)
143
58
42
43
22.4
22.9
21.6
22.8
(20.3 24.7)
(19.3 27.2)
(18.7 24.9)
(19.3 26.9)
13.0
14.0
11.1
13.0
(10.3 14.6)
(9.93 16.1)
(8.75 13.5)
(7.21 15.0)
22.0
22.2
21.3
23.2
(19.5 25.3)
(18.4 27.0)
(18.9 26.4)
(17.4 29.7)
35.3
35.3
35.1
33.7
(33.0 45.2)
(31.8 100)
(28.2 99.4)
(32.4 47.7)
167
68
56
43
Males
Females
19.1
19.0
18.7
19.9
(18.3 19.9)
(17.9 20.2)
(17.3 20.3)
(19.2 20.6)
11.7
11.6
11.4
11.9
(11.0 12.3)
(9.68 12.9)
(10.1 12.6)
(10.4 12.8)
18.9
18.5
18.6
20.1
(18.3 19.8)
(17.3 20.3)
(17.6 19.6)
(19.3 21.3)
31.1
31.3
29.6
31.9
(29.4 32.6)
(29.1 33.0)
(27.6 33.3)
(30.5 35.2)
992
300
280
412
18.0
17.7
18.3
18.1
(17.0 19.1)
(16.3 19.2)
(16.9 19.8)
(16.8 19.5)
11.4
11.5
11.6
10.4
(10.1 12.3)
(8.97 13.1)
(8.23 13.7)
(9.64 11.7)
18.3
17.5
18.8
18.6
(17.6 19.0)
(16.8 18.5)
(16.9 20.2)
(16.9 20.4)
28.3
27.4
28.7
29.9
(26.7 30.8)
(22.5 39.7)
(25.9 31.6)
(26.7 33.1)
472
128
140
204
20.2
20.3
19.2
21.5
(19.3 21.1)
(18.9 21.9)
(17.1 21.4)
(20.4 22.7)
12.1
11.5
11.4
13.5
(11.2 12.8)
(9.55 13.2)
(10.0 12.5)
(12.0 14.1)
20.2
20.5
18.4
21.6
(18.6 21.6)
(18.0 22.5)
(16.8 21.9)
(20.5 22.9)
32.9
32.6
32.3
33.6
(31.3 35.6)
(30.9 42.8)
(27.4 37.2)
(30.5 49.5)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
291
291
292
292
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(108 122)
(115 136)
(135 156)
(110 125)
(125 141)
(105 119)
(124 157)
(113 130)
117
133
111
140
122
(118 133)
115
125
145
125
Non-Hispanic Whites
Non-Hispanic Blacks
Mexican Americans
Race/ethnicity
Males
Females
Gender
4059 years
60 years and older
2039 years
54.4
64.9
54.7
53.9
57.8
54.3
54.1
64.5
54.9
(46.4 58.0)
(47.5 72.4)
(51.3 56.2)
(49.3 55.7)
(48.3 63.0)
(45.5 57.3)
(50.2 58.3)
(54.8 70.4)
(52.4 57.8)
58.8
72.5
59.5
57.9
65.2
58.1
60.6
73.5
61.1
(55.2 60.2)
(59.4 80.3)
(55.0 64.6)
(54.0 62.4)
(56.1 72.0)
(53.6 62.5)
(53.8 65.6)
(56.2 81.9)
(56.2 65.2)
111
133
117
114
127
111
121
142
121
(99.8 123)
(118 152)
(110 127)
(107 123)
(121 135)
(102 119)
(111 136)
(132 154)
(114 128)
211
304
259
253
293
254
272
305
277
(191 251)
(254 425)
(241 294)
(229 299)
(258 323)
(228 316)
(237 303)
(268 358)
(248 310)
250
348
315
303
337
316
305
373
323
(218 342)
(321 416)
(283 375)
(277 368)
(315 385)
(275 484)
(290 400)
(330 398)
(302 372)
376
310
992
865
943
610
515
683
1,808
Geometric mean and selected percentiles of plasma concentrations (in mol/L) for the fasted U.S. population aged 20 years and older, National
Health and Nutrition Examination Survey, 20032004.
Selected percentiles (95% conf. interval)
Sample
Geometric mean
2.5th
5th
50th
95th
97.5th
size
( 95% conf. interval)
50
100
150
Females
Males
4059
60+
2039
60+
NonHispanic Whites
50
100
150
200
250
NonHispanic Blacks
4059
Plasma docosahexaenoic
acid (mol/L)
2039
2039
4059
60+
2039
60+
Males
200
250
Females
4059
50
100
150
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Plasma docosahexaenoic
acid (mol/L)
Mexican Americans
200
250
Overall
Plasma docosahexaenoic
acid (mol/L)
2039
4059
Age (years)
60+
2039
4059
60+
Age (years)
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
293
293
125
115
125
145
(118 133)
(108 122)
(115 136)
(135 156)
71.7
67.0
70.1
84.2
(67.1 74.9)
(62.3 71.6)
(62.3 77.7)
(73.5 94.3)
121
111
121
142
(114 128)
(102 119)
(111 136)
(132 154)
227
204
217
247
(208 244)
(187 234)
(201 244)
(234 268)
1,808
610
515
683
117
107
122
131
(110 125)
(99.5 115)
(110 135)
(119 143)
67.9
62.3
68.7
77.8
(62.5 71.7)
(57.6 68.1)
(61.4 74.4)
(53.6 92.8)
114
102
118
125
(107 123)
(93.2 113)
(106 135)
(117 142)
206
186
219
219
(189 235)
(170 209)
(189 296)
(194 256)
865
282
248
335
133
123
128
158
(125 141)
(115 133)
(117 138)
(148 169)
75.6
72.4
72.3
91.4
(68.7 80.0)
(61.8 78.6)
(59.3 79.4)
(82.5 99.1)
127
117
124
154
(121 135)
(110 127)
(112 143)
(144 168)
238
220
210
272
(223 256)
(194 283)
(201 256)
(249 307)
943
328
267
348
Males
Females
111
102
127
129
(105 119)
(91.1 114)
(117 137)
(118 142)
67.1
60.0
84.9
81.2
(57.8 73.0)
(55.3 67.6)
(56.6 94.3)
(61.1 92.2)
111
100
125
131
(99.8 123)
(80.6 122)
(112 139)
(114 144)
185
161
189
202
(165 199)
(150 204)
(163 266)
(185 246)
376
132
93
151
107
96.1
129
120
(99.7 114)
(85.8 108)
(110 152)
(109 132)
64.8
59.4
83.3
69.0
(55.1 69.2)
(52.4 67.1)
(66.8 93.9)
(46.1 90.1)
104
99.4
127
121
(95.3 124)
(78.2 119)
(101 153)
(105 143)
165
147
194
190
(158 188)
(136 158)
(155 355)
(159 272)
189
67
48
74
118
110
124
139
(105 131)
(90.5 134)
(111 139)
(115 168)
68.8
60.4
87.9
88.9
(52.3 83.3)
(54.0 73.7)
(52.3 99.1)
(77.0 107)
116
109
119
133
(102 133)
(75.7 150)
(110 139)
(109 164)
191
191
173
229
(166 250)
(158 325)
(150 268)
(183 334)
187
65
45
77
Males
Females
294
294
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
140
128
142
173
(124 157)
(107 153)
(127 159)
(155 193)
83.4
77.2
84.1
117
(72.4 90.8)
(66.4 89.0)
(69.9 95.8)
(56.2 135)
133
119
133
173
(118 152)
(103 140)
(119 157)
(149 197)
251
237
234
258
(207 333)
(177 367)
(204 374)
(216 368)
310
126
98
86
129
112
143
161
(114 147)
(89.9 141)
(124 165)
(138 189)
72.4
67.9
77.8
113
(60.4 82.2)
(52.5 76.1)
(62.1 89.4)
(47.5 127)
124
107
131
159
(110 145)
(84.5 140)
(113 171)
(144 175)
233
193
283
251
(198 361)
(143 367)
(217 404)
(195 368)
143
58
42
43
148
142
141
181
(129 171)
(118 172)
(121 165)
(162 201)
96.2
93.1
90.3
121
(80.8 104)
(80.7 98.8)
(47.6 110)
(63.8 136)
136
127
132
182
(120 176)
(106 186)
(119 163)
(149 213)
254
254
208
258
(203 442)
(191 340)
(184 442)
(222 351)
167
68
56
43
Males
Females
122
111
118
142
(113 130)
(102 121)
(108 130)
(131 155)
69.8
65.2
65.9
84.2
(64.4 74.5)
(58.4 72.4)
(55.3 75.7)
(67.8 95.3)
117
110
114
136
(110 127)
(97.8 118)
(106 128)
(125 154)
215
201
206
244
(202 235)
(170 258)
(181 252)
(233 266)
992
300
280
412
113
102
115
128
(105 122)
(94.4 110)
(103 128)
(116 142)
65.3
60.8
64.9
77.0
(59.6 71.8)
(54.8 68.1)
(53.7 73.5)
(49.3 93.0)
112
96.1
113
121
(102 121)
(84.4 113)
(97.8 127)
(113 141)
198
180
194
213
(178 229)
(157 212)
(167 303)
(188 254)
472
128
140
204
130
121
122
156
(120 140)
(109 134)
(111 133)
(142 170)
74.4
72.4
68.0
89.5
(65.3 79.0)
(54.3 79.2)
(52.5 78.9)
(81.0 97.4)
124
114
120
150
(116 133)
(104 127)
(106 139)
(132 174)
229
204
207
274
(209 259)
(178 315)
(188 244)
(243 330)
520
172
140
208
Males
Females
2. Fat-Soluble
1. Water-Soluble
Vitamins & Nutrients
Vitamins
295
295
References
Astrup A, Dyerberg J, Elwood P, Hermansen K, Hu FB, Jakobsen MU, et al. The role of reducing intakes of
saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? Am J Clin Nutr.
2011;93:684688.
Cleeman JI, Grundy SM, Becker D, Clark LT, Cooper RS, Denke MA, et al. Executive summary of the Third
Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and
treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285(19):24862497
Harris WS, Mozaffarian D, Rimm E, Kris-Etherton P, Rudel LL, Appel LJ, et al. Omega-6 fatty acids and risk for
cardiovascular disease a science advisory from the American Heart Association Nutrition Subcommittee of the
Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on
Epidemiology and Prevention. Circulation. 2009;119:902907.
Hodson L, Skeaff CM, Fielding BA. Fatty acid composition of adipose tissue and blood in humans and its use as a
biomarker of dietary intake. Progress in Lipid Research. 2008;47:34880.
Hu FB. Are refined carbohydrates worse than saturated fat? Am J Clin Nutr. 2010;91:1541-2.
Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty
acids, cholesterol, protein, and amino acids. Washington, D.C.: National Academy Press; 2005.
International Life Sciences Institute. 8th edition. Present Knowledge in Nutrition. Washington, D.C.: ILSI Press; 2001.
Jakobsen MU, OReilly EJ, Heitmann BL, Pereira MA, Blter K, Fraser GE, et al. Major types of dietary fat and
risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr. 2009;89:14251432.
Jakobsen MU, Dethlefsen C, Joensen AM, Stegger J, Tjonneland A, Schmidt EB, Overvad K. Intake of
carbohydrates compared with intake of saturated fatty acids and risk of myocardial infarction: importance of the
glycemic index. Am J Clin Nutr. 2010; 91:17641768.
Kris-Etherton PM, Harris WS, Appel LJ, for the Nutrition Committee. Fish consumption, fish oil, omega-3 fatty
acids, and cardiovascular disease. Circulation. 2002;106:27472757.
Lagerstedt SA, Hinrichs DR, Batt SM, Magera MJ, Rinaldo P, McConnell JP. Quantitative determination of
plasma C8-C26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders. Mol Genet
Metab. 2001;73:3845.
Lichtenstein AH. Fats and oils. In: Benjamin C, ed. Encyclopedia of Human Nutrition. Oxford: Elsevier 2005.
pp.177186.
Micha R, Mozaffarian D. Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and
diabetes: a fresh look at the evidence. Lipids. 2010;45:893905.
Sun Q, Ma J, Campos H, Hankinson SE, Hu FB. Comparison between plasma and erythrocyte fatty acid content
as biomarkers of fatty acid intake in US women. Am J Clin Nutr. 2007;86:7481.
U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for
Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, December 2010 [cited 2011].
Available at: http://www.cnpp.usda.gov/DGAs2010-PolicyDocument.htm.
U.S. National Institutes of Health. National Cancer Institute. Sources of Saturated Fat, Stearic Acid, & Cholesterol
Raising Fat among the US Population, 200506. Risk Factor Monitoring and Methods Branch Web site. Applied
Research Program. Updated December 21, 2010a. Available at: http://riskfactor.cancer.gov/diet/foodsources/
sat_fat/.
U.S. National Institutes of Health. National Cancer Institute. Sources of Selected Fatty Acids among the US
Population, 200506. Risk Factor Monitoring and Methods Branch Web site. Applied Research Program. Updated
December 21, 2010b. Available at: http://riskfactor.cancer.gov/diet/foodsources/fatty_acids/.
Zelman K. The great fat debate: A closer look at the controversy - Questioning the validity of age-old dietary
guidance. J Am Diet Assoc. 2011;111(5):655658.
296
296
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3. Trace Elements
Iron-Status Indicators
Ferritin
Soluble transferrin receptor
Body iron
Iodine
3. Trace Elements
299
Iron-Status Indicators
Background Information
Sources and Physiological Functions. Iron functions as a component of proteins and enzymes.
Almost two-thirds of the iron in the body (approximately 2.5 grams of iron) is found in hemoglobin,
the protein in red blood cells that carries oxygen to tissues, and about 15% is in the myoglobin
of muscle tissue. The average American diet provides 1015 milligrams (mg) of iron daily in the
form of heme and nonheme iron. Heme iron is found in animal foods that originally contained
hemoglobin and myoglobin, such as red meat, fish, and poultry. Nonheme iron is found in plant
foods, such as lentils and beans, and also is provided in iron-enriched and iron-fortified foods.
Although heme iron is absorbed better than nonheme iron, most dietary iron is nonheme iron
(Miret 2003). Each day the body absorbs approximately 12 mg of iron to compensate for the 1
to 2 mg of iron that the (nonmenstruating) body loses (Institute of Medicine 2001). The current
Dietary Guidelines for Americans list iron as a nutrient of concern for specific population groups.
The guidelines recommend that pregnant women take an iron supplement, as recommended by an
obstetrician or other health care provider (U.S. Department of Agriculture 2010).
Health Effects. Transporting iron from one organ to another is accomplished by the reversible
binding of iron to the transport protein, transferrin, which will then form a complex with a highly
specific transferrin receptor (TfR) located on the plasma membrane surfaces of cells. Intracellular
iron availability is regulated through the increased expression of cellular TfR concentration by irondeficient cells. Ferritin is the major iron-storage compound: its production increases in cells as iron
supplies increase. The major function of ferritin is to provide a store of iron which may be used for
haem synthesis when required. Although all cells are capable of storing iron, the liver, spleen, and
bone marrow cells are primary iron-storage sites in people (Institute of Medicine 2001).
Iron deficiency and iron overload are the two major disorders of iron metabolism. Iron-deficiency
anemia is the most severe form of iron deficiency. It is linked to many adverse consequences of iron
deficiency, such as reduced physical capacity (Haas 2001) and poor pregnancy outcomes (Schorr
1994). Iron deficiency with and without anemia, however, has been linked to negative effects
on cognitive development among infants and adolescents (Beard 1999; Grantham-McGregor
2001). Iron overload is the accumulation of excess iron in body tissues, and it usually occurs as
a result of a genetic predisposition to absorb iron in excess of normal. However, it can also be
caused by excessive ingestion of iron supplements or multiple blood transfusions (Pietrangelo
2004). In advanced stages of iron overload disease (hemochromatosis), the iron accumulates in the
parenchymal cells of several organs, but particularly the liver, followed by the heart and pancreas;
this condition can lead to organ dysfunction and even death (Pietrangelo 2004).
Intake Recommendations. The Recommended Dietary Allowance (RDA) for all age groups of
men and postmenopausal women is 8 mg per day; the RDA for premenopausal women is 18 mg
per day. The Tolerable Upper Uptake Level for adults is 45 mg per day of iron, a level based on
gastrointestinal distress as an adverse effect (Institute of Medicine 2001).
Biochemical Indicators and Methods. Ferritin is present in the blood in very low concentrations.
Serum ferritin is in equilibrium with tissue stores, and its concentration declines early in the
development of iron deficiency. Low serum ferritin concentration thus is a sensitive indicator of
iron deficiency, but it does not necessarily reflect the severity of the depletion as it progresses (World
Health Organization 2011). Ferritin is also an acute-phase protein; acute and chronic diseases can
result in increased ferritin concentration, potentially masking an iron-deficiency diagnosis. A review
300
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
301
cutoff values necessary (Beard 2007). Recently, the WHO supported the development of a reference
reagent for sTfR by the NIBSC, and material 07-202 was released in 2010. It is hoped that this
material will be used by manufacturers to standardize sTfR assays and promote the establishment of
cutoff values used to assess the iron status of populations (Thorpe 2010).
Data in NHANES. Monitoring the iron status of the U.S. population has been an important
component since the inception of NHANES in 1971, and each NHANES has included a battery
of hematologic and biochemical indicators of iron status (Looker 1995). Since NHANES II (1976
1980), models that employ multiple biochemical iron-status indicators have been used to define
iron deficiency in the population (Pilch 1984). The ferritin model (also known as the three-indicator
model), using serum ferritin, transferrin saturation, and erythrocyte protoporphyrin, was developed
in 1980 and applied to NHANES III (19881994) as well as to the first few years of the continuous
NHANES survey beginning in 1999. Prevalence estimates of iron deficiency using the three-indicator
model were similar in NHANES III (Looker 1997) and in NHANES 19992000 (Looker 2002).
Starting in 2003, NHANES limited the population of interest to children (15 years) and women
of childbearing age (1249 years). Furthermore, the measurement of serum sTfR was introduced,
which allows the evaluation of iron status by the body iron model developed by Cook et al.
(2003). Using data for children and non-pregnant women from NHANES 20032006, Cogswell
et al. compared the new body iron model to the previously used ferritin model (2009). The
agreement between the two models was fair to good. Among non-pregnant women, the body iron
model produced lower estimates of iron deficiency prevalence and better predicted anemia. The
body iron model appeared to be less affected by inflammation than the ferritin model.
Two national health objectives that relate to iron deficiency reduction are part of the objectives for
Healthy People 2020: Objective NWS HP2020-21 (reduce iron deficiency among young children
and females of childbearing age) and Objective NWS HP2020-22 (reduce iron deficiency among
pregnant females) (http://www.healthypeople.gov/HP2020/). To provide data for these objectives,
NHANES continues with periodic monitoring of iron status in the population groups of interest.
Ferritin and sTfR data presented in this report were generated by use of commercial assay kits. Serum
ferritin was first measured by use of the BioRad QuantImune immunoradiometric assay (1999
2003), then by use of the Roche TinaQuant immunoturbidimetric assay on the Hitachi 912 clinical
analyzer (20042006). The public release data file for 20032004 has already been adjusted to the
new assay. We used adjustment equations provided in the analytical note for data from 19992002
to make the data comparable to the new assay (http://www.cdc.gov/nchs/nhanes/nhanes2003-2004/
L06TFR_C.htm#Analytic_Notes). Serum sTfR was measured with the Roche immunoturbidimetric
assay on the Hitachi 912 clinical analyzer (20032006). We calculated body iron by using the
following formula (Cook 2003): body iron (mg/kg) = -[log10 (sTfR * 1000 / ferritin) 2.8229] /
0.1207. The sTfR concentration in this formula represents an adjusted concentration to make the
Roche sTfR concentrations equivalent to the Flowers assay (1989) used in the development of the
body iron model: Flowers sTfR = 1.5 * Roche sTfR + 0.35 mg/L (Pfeiffer 2007).
To estimate the prevalence of low serum ferritin concentrations, we used the generally accepted
cutoff values mentioned above: 12 ng/mL for children 1-5 years of age and 15 ng/mL for women
of childbearing age and males 6 years and older. To estimate the prevalence of high serum ferritin
concentrations, we also used the cutoff values mentioned above: 150 ng/mL for women 12-49 years
of age and 200 ng/mL for men 12 years and older. Due to the lack of generally accepted cutoff
values for serum sTfR, we used the manufacturer provided assay-specific cutoff value of 4.4 mg/L to
estimate the prevalence of high sTfR concentrations in women of childbearing age. The prevalence
of low body iron (< 0 mg/kg) is indicative of the extent of iron deficiency in the population.
302
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Highlights
4FSVNDPODFOUSBUJPOTPGGFSSJUJOBOET5G3JOUIF64QPQVMBUJPOTIPXFEUIFGPMMPXJOH
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16
25
20
12
b
8
4
0
Prevalence (%)
20
15
10
5
Mexican
NonNonAmerican Hispanic Hispanic
black
white
Children 1-5 years
Mexican
NonNonAmerican Hispanic Hispanic
black
white
Women 12-49 years
Serum ferritin
< 15 ng/mL
Serum sTfR
> 4.4 mg/L
3. Trace Elements
303
Women were at risk for iron deficiency, while men were at risk for iron excess, as can be seen from
the large differences in the prevalence of low and high serum ferritin concentrations between men
and women (Figure H.3.c). During NHANES 19992002, the prevalence of low serum ferritin
concentrations (< 15 ng/mL) was much lower in 1249 year-old men (1%) than in 1249 yearold women (13%). Conversely, the prevalence of high serum ferritin concentrations (> 200 ng/
mL for men and > 150 ng/mL for women) was much higher in men (29%) than in women (6%).
NHANES 20032006 showed similar prevalence estimates for women as were seen in 1999
2002. No data are available for men in 20032006.
36
a
32
28
Prevalence (%)
24
20
16
12
b
8
4
0
Men
1999-2002
Women
1999-2002
Low serum ferritin
Women
2003-2006
Men
1999-2002
Women
1999-2002
Women
2003-2006
Figure H.3.c. Age-adjusted prevalence estimates of low (< 15 ng/mL) and high serum ferritin (> 200 ng/mL for men and > 150 ng/
mL for women) in U.S. men and women aged 1249 years, National Health and Nutrition Examination Survey, 19992006.
Error bars represent 95% confidence intervals. Within each ferritin status category, bars not sharing a common letter differ (p < 0.05). Age adjustment
was done using direct standardization.
Serum ferritin has been assessed as part of NHANES for many years, allowing for the evaluation
of temporal changes in concentrations. Overall, there were only minor changes in serum ferritin
concentrations in women of childbearing age over a period of almost two decades (Figure H.3.d).
Age-adjusted mean serum ferritin concentrations in women of childbearing age were slightly
lower (< 10%) in 19992002 and 20032006 than in 19881994. We observed the same pattern
for non-Hispanic white women, while serum ferritin concentrations decreased further during
20032006 for non-Hispanic black women. Mexican-American women had lower serum ferritin
concentrations in 19992002 than in 19881994, but concentrations in 20032006 did not
differ from concentrations in the two previous time periods.
304
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
60
50
b
40
a
b
b
b
a,b
b
1988-1994
30
1999-2002
20
2003-2006
10
0
Total population
Mexican American
NonHispanic black
NonHispanic white
Figure H.3.d. Age-adjusted geometric mean concentrations of serum ferritin in U.S. women aged 1249 years by race/ethnicity,
National Health and Nutrition Examination Survey, 19882006.
Error bars represent 95% confidence intervals. Within a demographic group, bars not sharing a common letter differ (p < 0.05). Age adjustment was
done using direct standardization.
Detailed Observations
The selected observations mentioned below are derived from the tables and figures presented next.
Statements about categorical differences between demographic groups noted below are based on
non-overlapping confidence limits from univariate analysis without adjusting for demographic
variables (e.g., age, sex, race/ethnicity) or other determinants of these blood concentrations (e.g.,
dietary intake, supplement usage, smoking, BMI). A multivariate analysis may alter the size
and statistical significance of these categorical differences. Furthermore, additional significant
differences of smaller magnitude may be present despite their lack of mention here (e.g., if
confidence limits slightly overlap or if differences are not statistically significant before covariate
adjustment has occurred). For a selection of citations of descriptive NHANES papers related to
these biochemical indicators of diet and nutrition, see Appendix G.
305
306
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3. Trace Elements
307
308
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
26.2
36.6
30.2
33.5
37.5
Race/ethnicity
Gender
26.2
29.3
38.1
43.2
35.7
15 years (Children)
1219 years (Women)
2039 years (Women)
4049 years (Women)
Age group
Total
(27.5 33.1)
(31.4 35.7)
(35.5 39.6)
(24.9 27.7)
(35.2 38.1)
(25.2 27.3)
(27.7 30.9)
(36.1 40.2)
(39.0 47.7)
(34.4 37.1)
4.18
4.13
4.89
6.90
4.62
6.68
4.64
4.67
4.38
4.65
(3.78 4.43)
(3.31 4.70)
(4.66 5.44)
(4.61 7.90)
(4.48 4.75)
(5.19 7.72)
(4.31 4.98)
(4.45 4.88)
(4.06 4.69)
(4.52 4.78)
4.87
5.49
8.07
8.90
6.80
9.14
6.83
7.19
5.81
6.99
(4.62 5.46)
(4.69 6.46)
(6.52 8.85)
(8.01 9.68)
(5.96 7.56)
(7.87 9.82)
(5.19 7.77)
(5.66 8.21)
(4.73 7.10)
(6.15 7.71)
31.7
33.7
38.2
26.9
38.1
26.7
31.9
40.5
45.9
36.2
(28.7 34.0)
(31.8 35.8)
(35.9 39.8)
(25.1 28.5)
(36.0 39.4)
(25.5 27.9)
(29.9 33.3)
(38.3 43.3)
(40.5 50.7)
(34.7 38.1)
121
165
143
63.6
145
65.6
81.4
135
211
143
(101 161)
(133 201)
(131 159)
(56.9 70.7)
(136 165)
(59.6 68.1)
(76.7 92.2)
(114 159)
(184 262)
(133 157)
166
212
194
77.9
198
77.5
103
176
264
194
(140 231)
(182 261)
(172 233)
(67.7 111)
(180 219)
(70.2 91.4)
(91.8 134)
(153 206)
(231 317)
(177 210)
1,704
1,676
2,089
757
5,255
1,482
1,991
1,780
759
6,012
Geometric mean and selected percentiles of serum concentrations (in ng/mL) for children aged 15 years and women aged 1249 years in the
U.S. population, National Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
60
20
40
Females
Males
Serum ferritin
(ng/mL)
80
Overall
15
1219
2039
4049
15
2039
4049
NonHispanic Whites
60
40
20
0
Serum ferritin
(ng/mL)
80
NonHispanic Blacks
1219
15
1219
2039
4049
15
1219
4049
Males
60
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Serum ferritin
(ng/mL)
80
Females
2039
15
1219
Age (years)
2039
4049
15
1219
2039
4049
Age (years)
3. Trace Elements
309
35.7
(34.4 37.1)
6.99
(6.15 7.71)
36.2
(34.7 38.1)
143
(133 157)
6,012
26.2
(25.2 27.3)
9.14
(7.87 9.82)
26.7
(25.5 27.9)
65.6
(59.6 68.1)
1,482
15 years
26.2
(24.9 27.7)
8.90
(8.01 9.68)
26.9
(25.1 28.5)
63.6
(56.9 70.7)
757
36.6
26.3
29.3
38.1
43.2
(35.2 38.1)
(24.9 27.7)
(27.7 30.9)
(36.1 40.2)
(39.0 47.7)
6.80
9.29
6.83
7.19
5.81
(5.96 7.56)
(6.81 10.1)
(5.19 7.77)
(5.66 8.21)
(4.73 7.10)
38.1
26.5
31.9
40.5
45.9
(36.0 39.4)
(24.8 28.0)
(29.9 33.3)
(38.3 43.3)
(40.5 50.7)
145
67.0
81.4
135
211
(136 165)
(59.2 74.3)
(76.7 92.2)
(114 159)
(184 262)
5,255
725
1,991
1,780
759
Males
Females
30.2
(27.5 33.1)
4.87
(4.62 5.46)
31.7
(28.7 34.0)
121
(101 161)
24.5
(22.8 26.3)
6.44
(4.69 7.69)
25.5
(23.5 27.6)
68.9
(57.7 83.3)
468
15 years
23.5
(21.3 25.9)
6.04
(4.33 7.21)
24.6
(23.1 27.0)
63.8
(52.5 118)
225
31.0
25.5
26.6
33.7
33.1
(28.0 34.5)
(23.6 27.6)
(24.8 28.5)
(29.2 38.9)
(25.7 42.7)
4.84
6.81
6.35
4.89
4.27
(4.59 5.33)
(4.56 9.78)
(4.85 7.38)
(4.62 5.51)
(3.48 4.66)
33.2
26.7
27.3
37.1
34.3
(29.3 36.1)
(23.2 29.8)
(25.5 29.2)
(31.6 43.9)
(28.3 42.9)
126
69.6
89.6
139
170
(104 167)
(60.7 88.6)
(80.6 97.3)
(106 213)
(134 262)
1,479
243
647
434
155
Males
Females
1,704
310
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
33.5
(31.4 35.7)
5.49
(4.69 6.46)
33.7
(31.8 35.8)
165
(133 201)
30.8
(28.9 32.8)
11.4
(9.51 14.2)
30.7
(28.7 32.7)
72.5
(65.8 88.9)
429
15 years
30.0
(27.3 32.9)
10.6
(5.39 14.4)
29.6
(26.6 33.4)
66.2
(58.1 96.6)
218
33.8
31.7
28.2
30.1
49.6
(31.5 36.2)
(29.8 33.7)
(25.5 31.2)
(27.9 32.4)
(40.4 61.0)
5.26
12.4
6.61
5.02
4.31
(4.56 6.25)
(9.78 14.6)
(4.97 7.55)
(4.22 6.08)
(< LOD 8.31)
34.1
31.6
31.1
31.1
53.5
(32.1 36.9)
(29.1 33.6)
(27.4 33.7)
(28.4 34.1)
(42.2 63.9)
171
75.8
88.7
132
257
(139 207)
(67.6 89.4)
(79.4 104)
(122 173)
(207 531)
1,458
211
674
375
198
Males
Females
1,676
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
37.5
(35.5 39.6)
8.07
(6.52 8.85)
38.2
(35.9 39.8)
143
(131 159)
25.9
(24.2 27.7)
9.30
(8.13 10.0)
26.3
(24.4 28.1)
61.4
(55.7 67.8)
416
15 years
26.1
(23.8 28.6)
9.13
(4.71 10.5)
27.1
(24.3 29.7)
56.9
(53.5 89.4)
229
38.5
25.6
30.0
41.0
43.6
(36.3 40.7)
(23.4 27.9)
(27.7 32.6)
(37.8 44.5)
(38.3 49.6)
7.96
9.40
6.88
8.75
6.61
(6.36 8.78)
(5.96 10.3)
(4.67 8.55)
(7.16 10.1)
(4.82 8.43)
39.4
25.5
33.0
42.3
46.1
(37.2 41.0)
(23.4 27.8)
(31.1 34.9)
(39.2 47.0)
(39.7 51.2)
144
63.7
78.2
134
212
(135 167)
(53.8 87.4)
(70.9 93.0)
(112 171)
(164 266)
1,860
187
520
812
341
Males
Females
2,089
3. Trace Elements
311
38.8
36.1
36.4
35.0
(36.7 41.0)
(34.2 38.0)
(34.7 38.3)
(32.9 37.2)
8.06
5.23
7.70
6.46
(5.23 9.99)
**
(5.80 8.58)
(5.69 7.19)
38.3
35.2
36.1
36.2
(34.7 42.5)
(33.2 37.2)
(34.6 38.6)
(33.6 38.7)
139
149
151
135
(129 173)
(136 175)
(141 173)
(113 167)
19992000
20012002
20032004
20052006
28.7
27.9
25.2
27.6
(26.9 30.7)
(25.6 30.5)
(23.7 26.8)
(26.0 29.2)
10.6
6.43
9.27
8.95
(5.95 13.5)
(5.23 9.79)
(8.08 9.76)
(7.95 9.78)
28.2
28.2
24.9
28.5
(26.0 31.6)
(26.2 30.4)
(23.2 26.7)
(27.4 30.1)
74.6
78.6
64.0
66.7
(57.9 94.2)
(68.5 105)
(57.0 67.8)
(63.2 77.2)
680
843
796
686
19992000
20012002
20032004
20052006
32.5
30.1
28.0
30.6
(29.6 35.8)
(28.5 31.9)
(25.5 30.7)
(28.6 32.8)
9.26
6.55
6.11
7.21
(5.23 10.4)
(5.23 8.62)
(4.43 7.97)
(5.52 8.79)
32.8
32.5
30.1
33.4
(29.6 37.1)
(29.9 33.7)
(27.9 32.7)
(30.9 35.7)
83.3
84.5
86.4
79.0
(79.4 99.7)
(79.3 95.6)
(75.6 102)
(75.0 94.0)
1,048
1,120
998
993
19992000
20012002
20032004
20052006
40.0
37.8
39.8
36.5
(36.0 44.4)
(35.2 40.5)
(37.1 42.7)
(33.5 39.9)
5.23
5.23
8.40
5.60
**
**
(7.52 9.20)
(4.70 7.17)
43.5
38.3
41.1
39.2
(36.3 52.2)
(34.5 41.7)
(39.2 44.6)
(34.1 44.6)
137
142
132
135
(118 187)
(119 192)
(111 172)
(110 179)
838
992
822
958
19992000
20012002
20032004
20052006
50.3
43.7
46.6
40.0
(43.6 57.9)
(39.3 48.6)
(39.9 54.4)
(34.5 46.3)
9.15
5.23
5.16
6.26
(5.23 12.1)
**
(4.21 8.44)
(4.89 6.96)
50.0
46.5
47.1
41.6
(42.8 59.8)
(39.2 53.9)
(43.5 53.6)
(34.0 51.7)
227
221
227
169
(202 275)
(195 249)
(197 317)
(144 264)
353
410
365
394
19992000
20012002
20032004
20052006
27.4
26.1
25.0
27.8
(25.4 29.6)
(23.4 29.0)
(23.1 27.1)
(25.8 29.9)
10.8
5.23
9.19
8.71
(6.11 13.1)
**
(6.68 10.2)
(8.18 9.54)
26.6
27.4
24.8
29.3
(24.7 28.4)
(24.4 30.3)
(22.5 27.0)
(26.9 31.0)
73.7
77.9
57.3
70.4
(55.4 95.7)
(67.2 112)
(55.3 67.6)
(55.8 105)
377
428
415
342
19992000
20012002
20032004
20052006
40.0
37.0
37.7
35.6
(37.7 42.5)
(35.2 38.9)
(35.6 39.8)
(33.4 37.9)
7.86
5.23
7.60
6.31
(5.23 9.85)
**
(5.49 8.51)
(5.46 7.04)
40.8
36.3
38.7
37.2
(37.0 45.1)
(34.5 38.3)
(36.0 40.1)
(34.2 40.0)
146
157
158
137
(132 179)
(141 186)
(143 186)
(115 176)
2,542
2,937
2,566
2,689
19992000
20012002
20032004
20052006
29.0
27.9
32.0
28.4
(26.6 31.6)
(25.6 30.4)
(27.4 37.4)
(25.7 31.4)
5.23
5.23
6.36
4.57
**
**
(4.30 7.98)
(4.01 5.22)
30.2
28.9
33.2
29.7
(27.9 32.7)
(26.8 31.3)
(28.1 36.8)
(27.6 32.9)
117
102
140
106
(81.2 179)
(82.4 162)
(98.8 203)
(98.4 119)
1,077
967
793
911
19992000
20012002
20032004
20052006
38.5
35.8
34.1
32.7
(34.3 43.3)
(31.0 41.3)
(30.5 38.2)
(30.5 35.1)
5.23
5.23
5.74
5.35
**
**
(4.17 7.50)
(4.67 6.15)
38.1
36.1
33.1
34.3
(33.1 44.9)
(32.7 40.2)
(30.0 36.9)
(31.1 38.1)
171
187
172
145
(130 382)
(138 263)
(127 267)
(127 179)
690
855
870
806
41.1
37.0
37.7
37.3
(38.4 44.0)
(34.2 40.1)
(35.1 40.5)
(34.1 40.7)
9.77
6.86
8.37
7.57
(5.23 12.4)
(5.23 8.38)
(4.79 10.0)
(6.33 8.68)
41.0
35.5
38.3
38.1
(35.1 47.1)
(32.8 38.6)
(35.6 39.7)
(34.4 41.1)
146
141
147
135
(131 181)
(124 188)
(136 190)
(113 176)
838
1,236
1,069
1,020
Age group
15 years (Children)
Gender
Non-Hispanic Blacks
Non-Hispanic Whites
19992000
20012002
20032004
20052006
2,919
3,365
2,981
3,031
** The minimum value is reported. The desired percentile does not exist because it is less than the estimated cumulative distribution evaluated at the minimum.
312
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
300
200
L
L
L
L
L
L
100
L
L
L
L
L
0
60
50th Percentile
50
L
40
L
L
L
L
L
L
30
L
L
20
10
L
L
L
L
L
L
L
L
L
L
L
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
15
Total
(M/F 15y,
F 1249y)
15y
611y
1219y
(F)
20+y
(F)
Males
(15y)
Females
(15,
1249y)
MA
(M/F 15y,
F 1249y)
NHB
(M/F 15y,
F 1249y)
NHW
(M/F 15y,
F 1249y)
3. Trace Elements
313
1,482
8.9
(7.1 11.2)
1,810,000
Males
Females
757
725
9.2
8.6
(7.1 11.9)
(6.2 11.8)
953,000
855,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
468
429
416
11.4
4.9
9.8
(8.6 15.1)
(3.1 7.8)
(6.9 13.7)
348,000
148,000
1,134,000
Race/ethnicity
314
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
4,530
13.6
(12.2 15.2)
10,748,000
1219 years
2049 years
1,991
2,539
15.2
13.2
(12.4 18.4)
(11.8 14.8)
2,462,000
8,299,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
1,236
1,247
1,673
18.6
19.9
11.3
(14.9 23.0)
(17.9 22.1)
(9.2 13.9)
1,427,000
2,140,000
5,805,000
Race/ethnicity
3. Trace Elements
315
4,530
5.2
(4.2 6.4)
4,086,000
1219 years
2049 years
1,991
2,539
0.9
6.2
(0.5 1.8)
(5.0 7.7)
149,000
3,900,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
1,236
1,247
1,673
4.2
7.1
4.9
(2.5 7.2)
(5.0 9.9)
(3.7 6.3)
324,000
759,000
2,495,000
Race/ethnicity
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
316
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
680
843
796
686
5.7
10.0
9.0
8.8
(3.3 9.6)
(7.0 13.9)
(6.6 12.3)
(6.0 12.8)
1,133,000
1,935,000
1,828,000
1,782,000
19992000
20012002
20032004
20052006
377
428
415
342
5.9
13.3
9.4
9.0
(3.3 10.4)
(8.6 20.1)
(6.6 13.3)
(5.8 13.8)
599,000
1,326,000
970,000
933,000
19992000
20012002
20032004
20052006
303
415
381
344
5.5
6.5
8.6
8.6
(2.4 12.0)
(4.3 9.6)
(5.6 12.8)
(4.8 14.9)
530,000
613,000
854,000
849,000
19992000
20012002
20032004
20052006
269
246
230
238
11.7
10.1
12.5
10.2
(7.7 17.4)
(7.4 13.6)
(7.6 19.8)
(8.1 12.8)
305,000
283,000
380,000
329,000
19992000
20012002
20032004
20052006
168
247
252
177
4.7
6.0
3.4
(2.6 8.4)
(3.1 11.3)
(1.7 6.9)
142,000
180,000
100,000
161
259
230
186
2.9
11.9
9.4
10.3
(1.3 6.1)
(7.1 19.2)
(5.5 15.5)
(6.1 16.7)
346,000
1,357,000
1,088,000
1,157,000
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
19992000
20012002
20032004
20052006
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
3. Trace Elements
317
2,239
2,522
2,185
2,345
11.4
13.9
13.2
14.0
(9.4 13.9)
(12.2 15.8)
(10.7 16.3)
(12.6 15.5)
8,767,000
10,821,000
10,460,000
11,069,000
19992000
20012002
20032004
20052006
1,048
1,120
998
993
11.5
13.9
17.4
12.9
(8.5 15.3)
(11.2 17.1)
(12.8 23.3)
(10.0 16.5)
1,781,000
2,201,000
2,825,000
2,119,000
19992000
20012002
20032004
20052006
1,191
1,402
1,187
1,352
11.4
13.9
12.2
14.2
(9.2 14.2)
(12.0 16.0)
(9.7 15.2)
(12.8 15.7)
6,986,000
8,620,000
7,670,000
8,938,000
19992000
20012002
20032004
20052006
808
721
563
673
18.8
21.9
16.7
20.6
(12.3 27.5)
(18.8 25.4)
(11.7 23.2)
(15.3 27.2)
1,140,000
1,541,000
1,276,000
1,632,000
19992000
20012002
20032004
20052006
522
608
618
629
16.4
19.5
19.1
20.7
(11.2 23.4)
(12.3 29.6)
(16.4 22.0)
(17.5 24.4)
1,764,000
2,091,000
2,051,000
2,256,000
677
977
839
834
9.1
11.6
11.8
10.9
(6.7 12.2)
(9.5 14.2)
(8.3 16.5)
(8.5 13.8)
4,741,000
6,025,000
6,032,000
5,500,000
Age group
1219 years
2049 years
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
19992000
20012002
20032004
20052006
318
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Age group
611 years
19992000
20012002
1219 years
19992000
20012002
2039 years
19992000
20012002
4059 years
19992000
20012002
Race/ethnicity
Mexican Americans
19992000
20012002
Non-Hispanic Blacks
19992000
20012002
Non-Hispanic Whites
19992000
20012002
3,488
3,849
1.1
1.3
(0.6 2.0)
(0.9 1.7)
1,323,000
1,576,000
463
509
1,078
1,094
2.1
2.8
(1.0 4.2)
(1.4 5.4)
336,000
463,000
632
724
0.5
(0.2 1.0)
176,000
570
770
745
752
2.0
(1.1 3.4)
384,000
1,196
958
1.0
0.7
(0.5 1.8)
(0.3 1.5)
91,000
77,000
781
921
1.3
(0.7 2.7)
187,000
1,223
1,678
1.3
1.3
(0.6 2.7)
(0.9 1.9)
1,100,000
1,159,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
3. Trace Elements
319
2,239
2,522
2,185
2,345
5.3
5.6
6.0
4.4
(4.0 7.0)
(4.5 7.0)
(4.7 7.5)
(2.9 6.6)
4,069,000
4,374,000
4,711,000
3,470,000
19992000
20012002
20032004
20052006
1,048
1,120
998
993
1.4
(0.6 3.2)
237,000
19992000
20012002
20032004
20052006
1,191
1,402
1,187
1,352
6.3
6.8
7.3
5.1
(4.8 8.3)
(5.3 8.5)
(5.9 9.1)
(3.2 7.9)
3,878,000
4,196,000
4,600,000
3,202,000
19992000
20012002
20032004
20052006
808
721
563
673
3.7
3.5
5.6
2.9
(1.7 7.9)
(1.8 6.8)
(2.7 11.3)
(1.4 5.7)
224,000
249,000
429,000
226,000
19992000
20012002
20032004
20052006
522
608
618
629
7.8
7.7
8.3
5.7
(5.2 11.6)
(5.0 11.8)
(4.6 14.7)
(4.2 7.9)
840,000
828,000
895,000
625,000
677
977
839
834
5.7
5.0
5.7
4.0
(4.1 8.0)
(3.4 7.2)
(4.1 7.8)
(2.5 6.3)
Age group
1219 years
2049 years
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
19992000
20012002
20032004
20052006
3,000,000
2,579,000
2,926,000
2,026,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
320
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Age group
1219 years
19992000
20012002
2039 years
19992000
20012002
4059 years
19992000
20012002
Race/ethnicity
Mexican Americans
19992000
20012002
Non-Hispanic Blacks
19992000
20012002
Non-Hispanic Whites
19992000
20012002
3,025
3,340
31.8
32.7
(27.7 36.3)
(30.1 35.5)
1,078
1,094
3.3
1.7
632
724
33.1
31.0
(26.8 40.1)
(27.1 35.1)
12,720,000
12,101,000
570
770
39.9
44.5
(33.0 47.1)
(39.0 50.2)
13,748,000
16,443,000
745
752
39.1
37.2
(33.2 45.2)
(32.3 42.4)
7,336,000
7,219,000
998
819
27.4
25.8
(23.1 32.1)
(21.3 31.0)
2,155,000
2,430,000
652
746
37.8
33.7
(32.8 43.2)
(28.7 39.2)
4,574,000
4,079,000
1,122
1,518
32.4
33.1
(27.5 37.6)
(29.9 36.5)
25,539,000
26,398,000
(1.8 6.0)
(1.0 2.9)
34,391,000
36,644,000
538,000
283,000
3. Trace Elements
321
322
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
4.38
3.51
3.62
4.19
3.43
Race/ethnicity
Gender
4.30
3.50
3.42
3.52
3.57
15 years (Children)
1219 years (Women)
2039 years (Women)
4049 years (Women)
Age group
Total
(3.53 3.72)
(4.10 4.29)
(3.35 3.52)
(4.28 4.48)
(3.45 3.57)
(4.24 4.37)
(3.44 3.55)
(3.36 3.49)
(3.38 3.65)
(3.51 3.63)
1.97
2.17
1.92
2.93
1.93
2.84
2.12
1.91
1.91
1.94
(1.93 2.03)
(1.97 2.33)
(1.89 1.94)
(2.75 2.98)
(1.91 1.95)
(2.73 2.90)
(1.96 2.21)
(1.85 1.94)
(1.71 1.95)
(1.91 1.96)
2.16
2.47
2.02
3.06
2.07
2.98
2.27
2.02
1.97
2.11
(2.06 2.24)
(2.31 2.57)
(1.94 2.17)
(2.95 3.18)
(1.97 2.18)
(2.91 3.06)
(2.20 2.35)
(1.95 2.13)
(1.93 2.05)
(1.99 2.20)
3.52
3.97
3.32
4.26
3.37
4.21
3.38
3.23
3.35
3.46
(3.42 3.62)
(3.91 4.04)
(3.22 3.44)
(4.13 4.41)
(3.29 3.47)
(4.11 4.29)
(3.32 3.46)
(3.15 3.32)
(3.17 3.56)
(3.37 3.55)
6.38
8.02
5.59
6.25
6.02
6.00
5.36
6.00
6.43
6.04
(5.92 7.10)
(7.31 9.69)
(5.28 6.07)
(5.94 6.63)
(5.83 6.36)
(5.91 6.42)
(5.22 5.82)
(5.75 6.36)
(6.07 6.98)
(5.90 6.36)
7.80
10.3
6.33
6.80
7.19
6.67
6.47
6.97
7.96
7.06
(6.96 8.77)
(9.78 12.6)
(5.96 7.33)
(6.48 7.45)
(6.79 7.67)
(6.45 7.17)
(5.95 7.32)
(6.50 7.88)
(7.12 9.13)
(6.78 7.62)
1,643
1,634
2,048
698
5,158
1,375
1,968
1,761
752
5,856
Geometric mean and selected percentiles of serum concentrations (in mg/L) for children aged 15 years and women aged 1249 years in the U.S.
population, National Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
Females
Males
Overall
15
1219
2039
4049
15
2039
4049
NonHispanic Whites
4
2
0
NonHispanic Blacks
1219
15
1219
2039
4049
15
1219
4049
Males
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Females
2039
15
1219
Age (years)
2039
4049
15
1219
2039
4049
Age (years)
3. Trace Elements
323
3.57
(3.51 3.63)
2.11
(1.99 2.20)
3.46
(3.37 3.55)
6.04
(5.90 6.36)
5,856
4.30
(4.24 4.37)
2.98
(2.91 3.06)
4.21
(4.11 4.29)
6.00
(5.91 6.42)
1,375
15 years
4.38
(4.28 4.48)
3.06
(2.95 3.18)
4.26
(4.13 4.41)
6.25
(5.94 6.63)
698
3.51
4.22
3.50
3.42
3.52
(3.45 3.57)
(4.12 4.31)
(3.44 3.55)
(3.36 3.49)
(3.38 3.65)
2.07
2.90
2.27
2.02
1.97
(1.97 2.18)
(2.83 3.00)
(2.20 2.35)
(1.95 2.13)
(1.93 2.05)
3.37
4.10
3.38
3.23
3.35
(3.29 3.47)
(3.99 4.27)
(3.32 3.46)
(3.15 3.32)
(3.17 3.56)
6.02
5.91
5.36
6.00
6.43
(5.83 6.36)
(5.68 6.16)
(5.22 5.82)
(5.75 6.36)
(6.07 6.98)
5,158
677
1,968
1,761
752
Males
Females
3.62
(3.53 3.72)
2.16
(2.06 2.24)
3.52
(3.42 3.62)
6.38
(5.92 7.10)
1,643
4.30
(4.17 4.43)
2.99
(2.94 3.07)
4.15
(3.99 4.32)
6.40
(6.06 7.18)
422
15 years
4.38
(4.21 4.56)
3.09
(2.90 3.21)
4.18
(4.00 4.36)
6.89
(6.00 8.30)
203
3.55
4.21
3.57
3.40
3.63
(3.45 3.65)
(4.08 4.35)
(3.46 3.68)
(3.27 3.54)
(3.32 3.96)
2.13
2.93
2.26
2.02
2.22
(2.01 2.22)
(2.58 3.07)
(2.18 2.36)
(1.93 2.12)
(1.80 2.30)
3.41
4.10
3.44
3.19
3.34
(3.27 3.54)
(3.94 4.31)
(3.33 3.59)
(3.01 3.40)
(3.02 3.71)
6.32
6.01
5.92
5.99
7.75
(5.85 7.25)
(5.66 7.53)
(5.27 6.92)
(5.62 7.63)
(6.29 11.7)
1,440
219
637
430
154
Males
Females
324
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
4.19
(4.10 4.29)
2.47
(2.31 2.57)
3.97
(3.91 4.04)
8.02
(7.31 9.69)
1,634
4.55
(4.43 4.67)
3.11
(3.02 3.29)
4.37
(4.26 4.56)
6.68
(6.31 7.16)
401
15 years
4.70
(4.56 4.86)
3.24
(3.06 3.37)
4.58
(4.30 4.89)
6.76
(6.42 7.77)
199
4.15
4.40
3.88
4.23
4.17
(4.05 4.26)
(4.21 4.59)
(3.77 4.00)
(4.08 4.39)
(3.89 4.47)
2.43
3.05
2.42
2.41
2.34
(2.27 2.55)
(2.73 3.23)
(2.25 2.52)
(2.06 2.58)
(1.94 2.61)
3.94
4.26
3.76
3.97
3.87
(3.86 4.00)
(4.00 4.47)
(3.66 3.87)
(3.85 4.15)
(3.51 4.08)
8.49
6.49
6.46
9.70
9.72
(7.37 9.87)
(5.96 7.16)
(6.14 7.07)
(7.33 10.5)
(8.28 13.2)
1,435
202
668
368
197
Males
Females
3.43
(3.35 3.52)
2.02
(1.94 2.17)
3.32
(3.22 3.44)
5.59
(5.28 6.07)
2,048
4.22
(4.11 4.32)
2.91
(2.78 3.04)
4.15
(4.01 4.28)
5.90
(5.63 6.19)
391
15 years
4.31
(4.16 4.46)
2.98
(2.91 3.15)
4.22
(3.99 4.48)
5.95
(5.67 6.83)
215
3.38
4.11
3.40
3.27
3.42
(3.30 3.47)
(3.96 4.27)
(3.33 3.46)
(3.18 3.36)
(3.26 3.59)
2.00
2.85
2.25
1.97
1.96
(1.97 2.05)
(2.64 2.97)
(2.12 2.35)
(1.94 2.01)
(1.92 2.01)
3.25
4.05
3.29
3.10
3.31
(3.14 3.37)
(3.88 4.27)
(3.20 3.37)
(3.00 3.20)
(3.03 3.57)
5.53
5.64
4.98
5.44
6.02
(5.18 6.08)
(5.36 6.64)
(4.78 5.49)
(4.96 6.01)
(5.41 6.76)
1,833
176
514
806
337
Males
Females
3. Trace Elements
325
3.63
3.51
(3.54 3.71)
(3.42 3.60)
2.06
2.13
(1.94 2.36)
(2.00 2.20)
3.55
3.36
(3.43 3.66)
(3.28 3.47)
5.96
6.16
(5.75 6.41)
(5.77 6.63)
2,831
3,025
20032004
20052006
4.44
4.16
(4.34 4.55)
(4.04 4.27)
3.28
2.86
(3.13 3.38)
(2.79 2.93)
4.33
4.06
(4.21 4.45)
(3.89 4.21)
5.99
6.08
(5.83 6.83)
(5.79 6.48)
696
679
20032004
20052006
3.57
3.43
(3.48 3.66)
(3.36 3.49)
2.29
2.26
(2.15 2.46)
(2.13 2.35)
3.49
3.33
(3.32 3.62)
(3.25 3.38)
5.72
5.23
(5.26 6.39)
(5.01 5.81)
975
993
20032004
20052006
3.49
3.35
(3.43 3.56)
(3.24 3.47)
2.02
2.02
(1.93 2.27)
(1.90 2.13)
3.33
3.16
(3.23 3.41)
(3.04 3.31)
5.96
6.07
(5.73 6.32)
(5.54 6.57)
803
958
20032004
20052006
3.49
3.54
(3.28 3.71)
(3.36 3.74)
1.96
2.05
(1.94 1.99)
(1.66 2.23)
3.33
3.37
(2.98 3.63)
(3.19 3.65)
6.01
6.86
(5.39 7.56)
(6.22 7.89)
357
395
20032004
20052006
4.54
4.21
(4.39 4.70)
(4.05 4.38)
3.32
2.94
(3.20 3.41)
(2.74 3.02)
4.40
4.16
(4.23 4.56)
(3.90 4.34)
6.38
6.04
(5.94 7.23)
(5.69 6.52)
358
340
20032004
3.56
3.46
(3.47 3.65)
(3.37 3.55)
2.03
2.11
(1.93 2.32)
(1.96 2.19)
3.45
3.31
(3.31 3.59)
(3.22 3.39)
5.94
6.17
(5.64 6.37)
(5.77 6.69)
2,473
2,685
20032004
20052006
3.63
3.62
(3.53 3.73)
(3.46 3.79)
2.18
2.15
(1.99 2.37)
(2.02 2.24)
3.59
3.46
(3.44 3.80)
(3.28 3.62)
5.88
7.32
(5.49 6.42)
(6.16 8.70)
734
909
20032004
20052006
4.18
4.20
(4.04 4.33)
(4.08 4.33)
2.54
2.36
(2.33 2.65)
(2.19 2.56)
3.96
4.00
(3.89 4.06)
(3.86 4.13)
7.97
8.17
(6.94 9.88)
(7.15 10.4)
832
802
3.51
3.36
(3.37 3.65)
(3.27 3.45)
1.99
2.09
(1.98 2.03)
(1.91 2.19)
3.44
3.24
(3.22 3.63)
(3.15 3.33)
5.68
5.55
(5.16 6.38)
(5.11 6.40)
1,026
1,022
Age group
15 years (Children)
1219 years (Women)
2039 years (Women)
4049 years (Women)
Gender
Non-Hispanic Blacks
Non-Hispanic Whites
20032004
20052006
326
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
12
95th Percentile
10
4
5.0
50th Percentile
4.5
1
1
4.0
3.5
1
1
1
1
3.0
3.5
1
2.5
1
2.0
1
1
1
1
1
1
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
1.5
0304
0506
5th Percentile
3.0
Total
(M/F 15y,
F 1249y)
15y
611y
1219y
(F)
20+y
(F)
Males
(15y)
Females
(15,
1249y)
MA
(M/F 15y,
F 1249y)
NHB
(M/F 15y,
F 1249y)
NHW
(M/F 15y,
F 1249y)
3. Trace Elements
327
4,481
18.9
(17.0 20.9)
14,918,000
1219 years
2049 years
1,968
2,513
16.9
19.4
(14.7 19.3)
(17.3 21.6)
2,741,000
12,159,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
1,221
1,233
1,657
19.0
34.9
16.0
(15.5 23.0)
(31.6 38.4)
(13.6 18.7)
1,451,000
3,756,000
8,177,000
Race/ethnicity
328
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Age group
1219 years
20032004
20052006
2049 years
20032004
20052006
Race/ethnicity
Mexican Americans
20032004
20052006
Non-Hispanic Blacks
20032004
20052006
Non-Hispanic Whites
20032004
20052006
2,135
2,346
18.8
18.9
(16.3 21.6)
(16.0 22.3)
14,862,000
15,017,000
975
993
17.4
16.4
(14.0 21.3)
(13.5 19.8)
2,818,000
2,694,000
1,160
1,353
19.2
19.6
(16.3 22.4)
(16.4 23.2)
12,031,000
12,296,000
547
674
18.7
19.2
(13.3 25.7)
(14.6 24.7)
1,435,000
1,516,000
604
629
33.2
36.7
(28.9 37.7)
(31.6 42.1)
3,568,000
3,988,000
823
834
16.1
15.8
(12.5 20.5)
(12.6 19.6)
8,258,000
7,991,000
3. Trace Elements
329
330
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3.38
5.30
4.49
4.37
5.46
Race/ethnicity
Gender
3.47
4.49
5.51
5.88
5.16
15 years (Children)
1219 years (Women)
2039 years (Women)
4049 years (Women)
Age group
Total
(4.10 4.88)
(4.10 4.64)
(5.24 5.69)
(3.17 3.59)
(5.13 5.46)
(3.31 3.63)
(4.26 4.72)
(5.29 5.73)
(5.46 6.30)
(5.01 5.31)
-4.49
-5.79
-3.17
-1.69
-3.78
-2.00
-3.37
-3.76
-4.43
-3.75
(-5.27 -3.69)
(-6.99 -4.66)
(-3.99 -2.25)
(-3.30 -1.25)
(-4.06 -3.50)
(-3.06 -1.34)
(-4.28 -2.61)
(-4.09 -3.12)
(-5.33 -3.76)
(-4.05 -3.41)
-3.16
-3.79
-1.21
-.715
-2.01
-.648
-1.59
-1.75
-2.85
-1.83
(-3.81 -2.03)
(-4.61 -2.88)
(-2.34 -.516)
(-1.36 -.262)
(-2.70 -1.43)
(-1.26 -.159)
(-2.69 -.763)
(-2.81 -1.22)
(-3.78 -1.84)
(-2.60 -1.41)
4.75
4.66
5.66
3.52
5.65
3.64
4.96
5.88
6.37
5.43
(4.44 5.12)
(4.30 5.05)
(5.49 5.81)
(3.32 3.80)
(5.49 5.76)
(3.44 3.79)
(4.71 5.16)
(5.69 6.17)
(5.86 6.82)
(5.32 5.58)
10.4
11.0
10.9
6.91
11.0
6.89
8.84
10.7
12.4
10.8
(9.73 11.2)
(10.3 11.6)
(10.5 11.5)
(6.65 7.30)
(10.7 11.4)
(6.72 7.06)
(8.35 9.34)
(10.2 11.1)
(11.7 12.9)
(10.6 11.2)
11.4
12.1
12.0
7.33
12.1
7.36
9.61
11.6
13.1
12.0
(10.8 12.9)
(11.3 13.2)
(11.5 12.7)
(6.93 8.12)
(11.6 12.6)
(7.17 7.87)
(9.23 10.2)
(11.0 12.4)
(12.7 14.2)
(11.5 12.5)
Arithmetic mean and selected percentiles of body iron (in mg/kg) for children aged 15 years and women aged 1249 years in the U.S.
population, National Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Arithmetic mean
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
1,641
1,633
2,041
695
5,150
1,369
1,967
1,758
751
5,845
Sample
size
Mexican Americans
Overall
4
2
0
Body iron
(mg/kg)
Females
Males
15
1219
2039
4049
15
2039
4049
NonHispanic Whites
4
2
0
Body iron
(mg/kg)
NonHispanic Blacks
1219
15
1219
2039
4049
15
1219
4049
Males
Females
2039
4
2
0
Body iron
(mg/kg)
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
15
1219
Age (years)
2039
4049
15
1219
2039
4049
Age (years)
3. Trace Elements
331
Males
15 years
Females
5.16
(5.01 5.31)
-1.83
(-2.60 -1.41)
5.43
(5.32 5.58)
10.8
(10.6 11.2)
5,845
3.47
(3.31 3.63)
-.648
(-1.26 -.159)
3.64
(3.44 3.79)
6.89
(6.72 7.06)
1,369
3.38
(3.17 3.59)
-.715
(-1.36 -.262)
3.52
(3.32 3.80)
6.91
(6.65 7.30)
695
5.30
(5.13 5.46)
-2.01
(-2.70 -1.43)
5.65
(5.49 5.76)
11.0
(10.7 11.4)
5,150
3.57
4.49
5.51
5.88
(3.36 3.78)
(4.26 4.72)
(5.29 5.73)
(5.46 6.30)
-.196
-1.59
-1.75
-2.85
(-2.11 .411)
(-2.69 -.763)
(-2.81 -1.22)
(-3.78 -1.84)
3.70
4.96
5.88
6.37
(3.41 4.04)
(4.71 5.16)
(5.69 6.17)
(5.86 6.82)
6.89
8.84
10.7
12.4
(6.67 7.27)
(8.35 9.34)
(10.2 11.1)
(11.7 12.9)
674
1,967
1,758
751
Males
15 years
Females
4.49
(4.10 4.88)
-3.16
(-3.81 -2.03)
4.75
(4.44 5.12)
10.4
(9.73 11.2)
1,641
3.16
(2.84 3.48)
-2.09
(-3.35 -1.36)
3.48
(3.13 3.78)
6.99
(6.57 7.93)
422
2.95
(2.48 3.41)
-2.71
(-4.72 -1.59)
3.34
(2.99 3.77)
6.92
(5.95 9.30)
203
4.66
(4.23 5.10)
-3.17
(-3.82 -1.90)
5.02
(4.60 5.44)
10.6
(9.79 11.4)
1,438
3.38
4.07
5.07
4.89
(3.04 3.72)
(3.76 4.39)
(4.48 5.67)
(3.74 6.04)
-1.88
-1.76
-3.15
-4.89
(-2.87 -.828)
(-3.29 -.981)
(-4.31 -1.66)
(-6.96 -3.40)
3.55
4.46
5.72
5.33
(3.22 4.15)
(4.26 4.68)
(4.93 6.28)
(4.42 6.59)
6.99
8.99
10.7
11.1
(6.78 8.13)
(8.51 9.69)
(9.89 12.0)
(10.4 15.1)
219
637
429
153
332
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Males
15 years
Females
4.37
(4.10 4.64)
-3.79
(-4.61 -2.88)
4.66
(4.30 5.05)
11.0
(10.3 11.6)
1,633
3.83
(3.56 4.09)
-.115
(-.906 .776)
3.95
(3.78 4.25)
7.51
(6.80 8.03)
401
3.63
(3.25 4.00)
-.328
(-2.15 .070)
3.77
(3.17 4.19)
6.90
(6.55 8.03)
199
4.43
(4.14 4.72)
-3.94
(-4.87 -3.04)
4.80
(4.35 5.16)
11.0
(10.4 11.9)
1,434
4.03
3.99
3.96
5.78
(3.73 4.34)
(3.56 4.42)
(3.63 4.28)
(4.86 6.69)
.658
-2.53
-4.12
-5.62
(-.541 .981)
(-3.91 -1.71)
(-5.73 -3.46)
(-9.51 -2.80)
4.17
4.46
4.35
6.68
(3.92 4.35)
(4.09 4.79)
(4.08 4.86)
(5.78 7.32)
7.71
8.91
9.96
12.9
(6.93 8.09)
(8.38 9.43)
(9.46 11.2)
(11.9 15.4)
202
667
368
197
Males
15 years
Females
5.46
(5.24 5.69)
-1.21
(-2.34 -.516)
5.66
(5.49 5.81)
10.9
(10.5 11.5)
2,041
3.51
(3.27 3.74)
-.264
(-1.28 .300)
3.56
(3.34 3.92)
6.89
(6.64 7.00)
385
3.42
(3.09 3.75)
-.571
(-1.39 .140)
3.50
(3.06 4.01)
6.91
(6.45 7.33)
212
5.60
(5.36 5.84)
-1.27
(-2.60 -.546)
5.81
(5.66 6.02)
11.0
(10.7 11.5)
1,829
3.61
4.68
5.93
6.01
(3.33 3.89)
(4.35 5.02)
(5.58 6.28)
(5.45 6.57)
.062
-1.48
-.640
-2.26
(-3.13 .791)
(-3.15 -.417)
(-2.73 .779)
(-3.78 -1.01)
3.67
5.17
6.16
6.36
(3.35 4.03)
(4.86 5.50)
(5.82 6.59)
(5.77 6.99)
6.70
8.84
10.7
12.4
(6.45 7.27)
(8.29 9.62)
(10.2 11.4)
(11.6 13.0)
173
514
805
337
3. Trace Elements
333
5.21
5.11
(5.03 5.39)
(4.85 5.38)
-1.60
-2.04
(-2.96 -.854)
(-2.73 -1.43)
5.43
5.43
(5.32 5.55)
(5.08 5.71)
10.9
10.8
(10.7 11.3)
(10.2 11.5)
2,826
3,019
20032004
20052006
3.25
3.70
(3.01 3.50)
(3.47 3.94)
-.651
-.642
(-1.73 .144)
(-1.65 -.080)
3.34
3.91
(2.99 3.66)
(3.70 4.14)
6.55
7.00
(6.39 6.73)
(6.92 7.33)
694
675
20032004
20052006
4.27
4.71
(3.89 4.66)
(4.45 4.96)
-2.23
-1.45
(-3.93 -.653)
(-2.64 -.527)
4.71
5.10
(4.27 5.11)
(4.85 5.33)
8.89
8.53
(8.29 9.73)
(8.31 9.55)
974
993
20032004
20052006
5.61
5.42
(5.33 5.89)
(5.04 5.79)
-1.21
-2.55
(-2.14 -.835)
(-3.91 -1.41)
6.07
5.83
(5.69 6.25)
(5.44 6.27)
10.4
10.8
(9.92 11.1)
(10.2 11.9)
801
957
20032004
20052006
6.22
5.55
(5.61 6.82)
(4.89 6.21)
-3.28
-2.47
(-3.80 -1.85)
(-4.61 -1.59)
6.85
5.96
(6.21 7.33)
(5.33 6.66)
12.7
11.8
(12.0 13.4)
(11.1 13.1)
357
394
20032004
20052006
3.11
3.68
(2.76 3.46)
(3.41 3.95)
-.719
-.746
(-1.89 -.152)
(-1.32 -.268)
3.13
3.91
(2.70 3.65)
(3.48 4.41)
6.21
7.24
(5.74 6.92)
(6.81 8.27)
358
337
20032004
5.38
5.22
(5.18 5.58)
(4.94 5.49)
-1.76
-2.20
(-3.18 -.854)
(-2.98 -1.52)
5.66
5.60
(5.50 5.80)
(5.32 5.84)
11.0
10.9
(10.7 11.5)
(10.2 11.6)
2,468
2,682
20032004
20052006
4.74
4.26
(4.13 5.35)
(3.78 4.73)
-2.05
-3.70
(-3.57 -1.13)
(-5.21 -2.73)
4.94
4.71
(4.28 5.64)
(4.31 5.05)
10.6
9.91
(9.69 12.5)
(9.73 10.8)
734
907
20032004
20052006
4.48
4.26
(4.02 4.94)
(3.94 4.58)
-3.79
-3.96
(-5.06 -2.47)
(-4.99 -2.62)
4.68
4.66
(4.15 5.24)
(4.16 5.17)
11.1
10.6
(9.95 12.7)
(9.86 11.4)
831
802
5.45
5.48
(5.14 5.75)
(5.12 5.85)
-.903
-1.39
(-3.69 .285)
(-2.45 -.593)
5.57
5.70
(5.43 5.76)
(5.42 6.01)
11.0
10.9
(10.5 11.6)
(10.2 12.0)
1,023
1,018
Age group
15 years (Children)
1219 years (Women)
2039 years (Women)
4049 years (Women)
Gender
Non-Hispanic Blacks
Non-Hispanic Whites
20032004
20052006
334
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
12
j
j
j
j
10
j
j
8
j
j
j
j
j
4
7
j
50th Percentile
j
j
3
2
2
j
j
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
0304
0506
6
0304
0506
5th Percentile
Total
(M/F 15y,
F 1249y)
15y
611y
1219y
(F)
20+y
(F)
Males
(15y)
Females
(15,
1249y)
MA
(M/F 15y,
F 1249y)
NHB
(M/F 15y,
F 1249y)
NHW
(M/F 15y,
F 1249y)
3. Trace Elements
335
1,369
6.7
(5.0 8.8)
Males
Females
695
674
7.8
5.4
(5.6 10.8)
(3.4 8.3)
807,000
534,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
422
401
385
10.9
5.1
5.8
(8.1 14.6)
(3.0 8.6)
(3.6 9.1)
333,000
154,000
670,000
Race/ethnicity
336
1,350,000
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
4,476
9.5
(8.6 10.5)
7,515,000
1219 years
2049 years
1,967
2,509
9.3
9.6
(7.4 11.6)
(8.6 10.7)
1,508,000
6,006,000
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
1,219
1,232
1,656
13.2
16.2
7.4
(10.2 16.9)
(13.9 18.7)
(5.8 9.4)
1,007,000
1,739,000
3,803,000
Race/ethnicity
3. Trace Elements
337
Gender
Males
20032004
20052006
Females
20032004
20052006
Race/ethnicity
Mexican Americans
20032004
20052006
Non-Hispanic Blacks
20032004
20052006
Non-Hispanic Whites
20032004
20052006
694
675
6.5
6.8
(4.3 9.8)
(4.5 10.2)
1,321,000
1,377,000
358
337
8.3
7.3
(4.9 13.7)
(4.7 11.1)
854,000
755,000
336
338
4.5
6.3
(2.7 7.4)
(3.1 12.4)
449,000
620,000
187
235
13.3
8.6
(8.4 20.5)
(6.0 12.1)
405,000
275,000
228
173
6.1
(3.1 11.8)
183,000
201
184
4.6
7.0
(2.1 10.0)
(3.8 12.5)
538,000
792,000
Estimate flagged: 30% RSE < 40% for the prevalence estimate.
Estimate suppressed: RSE 40% for the prevalence estimate.
338
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Age group
1219 years
20032004
20052006
2049 years
20032004
20052006
Race/ethnicity
Mexican Americans
20032004
20052006
Non-Hispanic Blacks
20032004
20052006
Non-Hispanic Whites
20032004
20052006
2,132
2,344
8.6
10.4
(7.0 10.4)
(9.3 11.7)
6,773,000
8,266,000
974
993
9.0
9.6
(6.3 12.6)
(6.9 13.2)
1,455,000
1,576,000
1,158
1,351
8.5
10.6
(6.8 10.5)
(9.5 11.9)
5,322,000
6,681,000
547
672
11.2
15.1
(7.6 16.2)
(10.5 21.2)
857,000
1,193,000
603
629
16.0
16.3
(12.8 19.8)
(13.1 20.1)
1,720,000
1,777,000
822
834
6.9
8.0
(4.4 10.6)
(6.0 10.5)
3,530,000
4,023,000
3. Trace Elements
339
References
Beard JL. Iron deficiency and neural development: an update. Arch Latinoam Nutr. 1999;49(3 Suppl 2):34S39S.
Beard J. Indicators of the iron status of the population: free erythrocyte protoporphyrin and zinc protoporphyrin;
serum and plasma iron, total iron binding capacity and transferrin saturation; and serum transferrin receptor. In:
WHO/CDC. Assessing the iron status of populations: report of a joint World Health Organization/Centers for
Disease Control and Prevention technical consultation on the assessment of iron status at the population level.
Geneva: World Health Organization; 2007 [cited 2011]. Available at: http://www.who.int/nutrition/publications/
micronutrients/anaemia_iron_deficiency/9789241596107.pdf.
Cogswell ME, Looker AC, Pfeiffer CM, Cook JD, Lacher DA, Beard JL, et al. Assessment of iron deficiency in
US preschool children and nonpregnant females of childbearing age: National Health and Nutrition Examination
Survey 20032006. Am J Clin Nutr. 2009;89:13341342.
Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood. 2003;101:33593364.
Flowers CH, Skikne BS, Covell AM, Cook JF. The clinical measurement of serum transferrin receptor. J Lab Clin
Med. 1989;114:368377.
Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in
children. J Nutr. 2001;131(2S-2):649S656S.
Haas JD, Brownlie T 4th. Iron deficiency and reduced work capacity: a critical review of the research to determine a
causal relationship. J Nutr. 2001;131:691S696S.
Institute of Medicine, Food and Nutrition Board. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron,
chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc. Washington, D.C.:
National Academy Press; 2001.
Kuiper-Kramer EPA, Coenen JLLM, Huisman CMS, Abbes A, van Raan J, van Eijk HG. Relation between soluble
transferrin receptors in serum and membrane-bound transferrin receptors. Acta Haematol. 1998;99:811.
Looker AC, Gunter EW, Johnson CL. Methods to assess iron status in various NHANES surveys. Nutr Rev.
1995;53:246254.
Looker AC, Dallman PR, Carroll M, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States.
JAMA. 1997;277:973975.
Looker AC, Cogswell ME, Gunter EW. Iron deficiencyUnited States, 19992000. Morb Mortal Wkly Rep.
2002;51:897899.
Miret S, Simpson RJ, McKie AT. Physiology and molecular biology of dietary iron absorption. Annu Rev Nutr.
2003;23:283301.
Pfeiffer CM, Cook JD, Mei Z, Cogswell ME, Looker AC, Lacher DA. Evaluation of an automated soluble
transferrin receptor (sTfR) assay on the Roche Hitachi analyzer and its comparison to two ELISA assays. Clin
Chim Acta 2007;382:112116.
Pietrangelo A. Hereditary hemochromatosisa new look at an old disease. N Engl J Med. 2004;350:23822397.
Pilch SM, Senti FR, editors. Assessment of iron nutritional status of the U.S. population based on data collected
in the Second National Health and Nutrition Examination Survey, 19761980. Bethesda (MD): Federation of
American Societies for Experimental Biology; 1984.
Schorr TO, Hediger ML. Anemia and iron-deficiency anemia: compilation of data on pregnancy outcome. Am J
Clin Nutr. 1994;59(Suppl):492S501S.
Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a quantitative measure of tissue iron deficiency.
Blood. 1990;75:18701876.
Thorpe SJ. The development and role of international biological reference materials in the diagnosis of anaemia.
Biologicals 2010;38:449458.
U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for
th
Americans, 2010. 7 Edition, Washington, DC: U.S. Government Printing Office, December 2010 [cited 2011].
Available at: http://www.cnpp.usda.gov/DGAs2010-PolicyDocument.htm.
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2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
World Health Organization (WHO)/UNICEF/UNU. Iron deficiency anaemia: assessment, prevention, and
control. A guide for programme managers. Geneva: World Health Organization; 2001 (WHO/NHD/01.3) [cited
2011]. Available at:
http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/WHO_NHD_01.3/en/index.
html.
World Health Organization (WHO)/CDC. Assessing the iron status of populations: report of a joint World Health
Organization/Centers for Disease Control and Prevention technical consultation on the assessment of iron status at
the population level. Geneva: World Health Organization; 2005 [cited 2011]. Available at: http://whqlibdoc.who.
int/publications/2004/9241593156_eng.pdf.
WHO. Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations. Vitamin
and Mineral Nutrition Information System. Geneva, World Health Organization; 2011 (WHO/NMH/NHD/
MNM/11.2). (http://www.who.int/vmnis/indicators/serum_ferritin.pdf, accessed February 14, 2012).
Worwood M. The measurement of ferritin. In: Rowan, van Assendelft, Preston, editors. Advanced Laboratory
Methods in Haematology. Hodder Arnold; 2002a. pp. 241263.
Worwood M. Serum transferrin receptor assays and their application. Ann Clin Biochem. 2002b;39:221230.
Worwood M. Indicators of the iron status of populations: ferritin. In: WHO/CDC. Assessing the iron status of
populations: report of a joint World Health Organization/Centers for Disease Control and Prevention technical
consultation on the assessment of iron status at the population level. Geneva: World Health Organization;
2007 [cited 2011]. Available at: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_
deficiency/9789241596107.pdf.
3. Trace Elements
341
Iodine
Background Information
Sources and Physiological Functions. Iodine, a trace element found in soil, is an essential
component of the thyroid hormones involved in regulating the bodys metabolic processes
related to normal growth and development. Across the world, iodized salt and seafood are the
major dietary sources of iodine. In the United States, where the addition of iodine to salt is not
mandatory, most people get their iodine from dairy products and grains (bread) (Murray 2008).
In the United States, salt is iodized with potassium iodide at 100 parts per million (76 milligram
[mg] of iodine per kilogram [kg] of salt). Iodized salt is chosen by about 5060% of the U.S.
population (Institute of Medicine 2001). Still, most ingested salt comes from processed food
(approximately 70%), which is typically not iodized in either the United States or in Canada (The
Public Health Committee of the American Thyroid Association 2006). Dairy products have been
identified as another important contributor to iodine status among reproductive-age women in
the United States (Perrine 2010).
Health Effects. Iodine deficiency disorders include mental retardation, hypothyroidism, goiter,
cretinism, and varying degrees of other growth and developmental abnormalities. Iodine deficiency
is the most preventable cause of mental retardation in the world (World Health Organization 2007).
Thyroid enlargement (goiter) is usually the earliest clinical feature of iodine deficiency. Thyroid
hormone is particularly important in the development of the central nervous system during the fetal
and early postnatal periods. In areas where iodized salt is common, iodine deficiency is rare. The
most critical period for iodine sufficiency is in utero through the first two years of life, when thyroid
hormones are required for normal brain development (World Health Organization 2007).
Excess iodine intake may also result in goiter, as well as in hyper- or hypothyroidism. High
iodine intake has also been associated with increased risk for thyroid papillary cancer (Institute of
Medicine 2001). For most people, iodine intake from usual foods and supplements is unlikely to
exceed the tolerable upper intake level (1100 g/day) (Institute of Medicine 2001).
Intake Recommendations. The Institute of Medicine recommends the following daily intake of
iodine: 90 g for children 1 to 8 years, 120 g for children 9 to 13 years, 150 g for adolescents
(14 to 18 years) and for nonpregnant adults, 220 g per day for pregnant women, and 290 g
per day during lactation (Institute of Medicine 2001). Dietary iodine requirements are higher in
pregnancy because of increased thyroid hormone production, increased renal iodine excretion,
and fetal iodine requirements (Glinoer 2007).
The World Health Organization (WHO)
recommends the following daily intake of iodine:
90 g for preschool children (0 to 59 months);
120 g for schoolchildren (6 to 12 years); 150 g
for adolescents (above 12 years) and adults; and
250 g for pregnant and lactating women (World
Health Organization 2007). The American
Thyroid Association recommends that North
American women receive dietary supplements
containing 150 g iodine daily during pregnancy
and lactation and that all prenatal vitamins
contain 150 g of iodine (Becker 2006). An
Endocrine Society Clinical Practice Guideline on
the management of thyroid dysfunction during
342
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
pregnancy and postpartum recommends an average daily intake of 250 g iodine for pregnant
women (Abalovich 2007). These recommendations have not yet been widely adopted. A current
survey of prenatal multivitamins marketed in the United States showed that 49% did not contain
iodine (Leung 2009). Furthermore, the majority of women of childbearing age (> 80%) are not
consuming supplements containing iodine (Gregory 2009).
Biochemical Indicators. Iodine deficiency develops when iodide intake is less than 20 g/day
(Beers 2006). Most dietary iodine absorbed in the body eventually appears in the urine; thus,
urinary iodine excretion is recommended for assessing recent dietary iodine intake worldwide
(World Health Organization 2007).
WHO categories for median urinary iodine concentrations in school-age children and adults
(excluding pregnant and lactating women) are widely used to define iodine intake and nutrition
status for populations (World Health Organization 2007). An additional adequacy criterion
is that not more than 20% of samples from children and non-pregnant women be below 50
nanograms per milliliter (ng/mL) of iodine. These categories are useful for classifying population
risk, but they are not categories to define individual risk for adverse health outcomes. The large
day-to-day variations in urine iodine excretion, even among individuals with stable iodine intake,
tend to offset one another when the sample includes an adequately large number (100500 spot
urine samples per group or subgroup) of representative individuals (Andersen 2008).
Epidemiological criteria for assessing iodine nutrition based on median urinary iodine
concentrations of school-age children (> 6 years)* (World Health Organization 2007)
Median Urinary
Iodine (ng/mL)
< 20
2049
5099
100199
Iodine Intake
Iodine Status
Insufficient
Insufficient
Insufficient
Adequate
200299
Above
requirements
300
Excessive
For pregnant women, median urinary iodine concentrations of 150249 ng/mL represent
adequate iodine intake (World Health Organization 2007; Andersson 2007). Median urinary
iodine concentrations of < 150 ng/mL represent insufficient intake; 250499 ng/mL represent
an intake above requirements, and 500 ng/mL represent an excessive intake. For lactating
women and children less than 2 years of age, median urinary iodine concentrations of 100 ng/
mL represent adequate iodine intake, but no other categories of iodine intake are defined (World
Health Organization 2007; Andersson 2007).
Data in NHANES. NHANES has measured urinary iodine since 1971. The NHANES III survey
(19881994) showed a sizable decrease in urinary iodine concentrations compared to concentrations
measured during NHANES I (19711974) (Hollowell 1998). This decline may have been due
to the dairy industrys effort in the mid-1980s to reduce the iodine residue in milk from feed
supplements and iodophor sanitizing agents (Pennington 1996). Decreased concentrations of iodine
in fruit-flavored breakfast cereals resulted from a ban on erythrosine (an iodine-containing food
3. Trace Elements
343
EZF
BOEDPVMEBMTPIBWFDPOUSJCVUFEUPUIFEFDMJOFJOVSJOBSZJPEJOFDPODFOUSBUJPOT 1FOOJOHUPO
4JODF
VSJOBSZJPEJOFIBTCFFONFBTVSFEJOUIFDPOUJOVPVT/)"/&4TVSWFZ4UBSUJOH
XJUI/)"/&4
$%$VTFEBOFXNFUIPE
JOEVDUJWFMZDPVQMFEQMBTNBNBTTTQFDUSPNFUSZ
*$1.4
UPNBLFUIFTFNFBTVSFNFOUT $BMEXFMM
JTNFUIPEQSPEVDFEDPNQBSBCMFEBUB
UPUIFFTUBCMJTIFE4BOEFMM,PMUIPTQFDUSPQIPUPNFUSJDNFUIPEVTFEJO/)"/&4*** 1JOP
8IFO$%$MBCPSBUPSZTDJFOUJTUTNFBTVSFEVSJOBSZJPEJOFDPODFOUSBUJPOTJO/)"/&4o
$BMEXFMM
o $BMEXFMM
BOEoBOEo $BMEXFMM
UIFZGPVOEUIBUUIF64NFEJBOVSJOBSZJPEJOFDPODFOUSBUJPOIBETUBCJMJ[FETJODFUIFJOJUJBMESPQ
UIBUIBEPDDVSSFEGSPN/)"/&4*UP/)"/&4***BOEUIBUJUSFQSFTFOUFEBEFRVBUFJPEJOFJOUBLF
GPSUIFPWFSBMMQPQVMBUJPOZFBSTBOEPMEFSFNFEJBO DPOEFODFJOUFSWBM
VSJOBSZJPEJOF
DPODFOUSBUJPOGPSQSFHOBOUXPNFO< o
OHN->XBTCFMPXUIFDVUPWBMVFPGOHN-
JOEJDBUJOHJPEJOFEFDJFODZ
IPXFWFSUIFTBNQMFXBTTNBMM O
$BMEXFMM
$POUJOVFE
NPOJUPSJOHPGUIFQPQVMBUJPOGPSJPEJOFTVDJFODZJTXBSSBOUFECFDBVTFPGHSPVQTBUSJTLGPSJPEJOF
EFDJFODZEJTPSEFST
For more information about iodine
TFFUIF*OTUJUVUFPG.FEJDJOFT%JFUBSZ3FGFSFODF*OUBLF
SFQPSU *OTUJUVUFPG.FEJDJOF
Highlights
6SJOBSZJPEJOFDPODFOUSBUJPOTJOUIF64QPQVMBUJPOTIPXFEUIFGPMMPXJOHEFNPHSBQIJDQBUUFSOT
BOEDIBSBDUFSJTUJDT
t FMPXFTUDPODFOUSBUJPOTXFSFPCTFSWFEJOZPVOHXPNFO
XIJMFUIFIJHIFTU
DPODFOUSBUJPOTXFSFPCTFSWFEJODIJMESFO
t /PDPOTJTUFOUQBUUFSOXBTPCTFSWFEXJUISFHBSEUPSBDFFUIOJDJUZ
t $PODFOUSBUJPOTIBWFCFFOSFMBUJWFMZTUBCMFTJODFUIFMBUFT
FJPEJOFJOUBLFPGUIF64QPQVMBUJPOBQQFBSFEUPCFBEFRVBUFPOUIFCBTJTPGNFEJBOVSJOBSZ
JPEJOFDPODFOUSBUJPOT)PXFWFS
XPNFOBHFEoZFBSTIBEUIFMPXFTUJPEJOFJOUBLF
KVTU
TMJHIUMZBCPWFJOTVDJFOUJOUBLF 'JHVSF)F
:PVOHXPNFONFSJUTQFDJBMBUUFOUJPOUPFOTVSF
UIFCFTUQPTTJCMFCSBJOEFWFMPQNFOUPGUIFGFUVTEVSJOHQSFHOBODZ8IJMFOPBHFHSPVQIBEB
NFEJBOVSJOBSZJPEJOFDPODFOUSBUJPOUIBUSFQSFTFOUFEFYDFTTJWFJPEJOFJOUBLF
CPZToZFBSTPG
BHFIBEUIFIJHIFTUJOUBLF
BOEUIFVQQFSDPOEFODFMJNJUPGUIFNFEJBOXBTKVTUTMJHIUMZXJUIJO
UIFSBOHFPGFYDFTTJWFJOUBLF 'JHVSF)F
Males
Females
400
Excessive intake
300
Above requirements
200
Adequate intake
100
Insufficient intake
0
6-11
12-19
20-39
40-59
60
Age (years)
Figure H.3.e. Median concentrations of urinary iodine in the U.S. population aged 6 years and older by age group and gender
associated with estimated iodine intake, National Health and Nutrition Examination Survey, 20012006.
Error bars represent 95% confidence intervals.
344
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Urinary iodine concentrations have been relatively stable over almost two decades between 1988
2006 (Figure H.3.f ). They increased slightly (< 20%) between 19881994 and 20012002 in
the total population, in males, in females, and in non-Hispanic whites. However, they remained
unchanged in non-Hispanic blacks and Mexican Americans.
1988-1994
2001-2002
2003-2006
b
200
b
150
a
a
100
50
0
Total
population
Males
Females
Mexican
American
NonHispanic
NonHispanic
black
white
Figure H.3.f. Age-adjusted geometric mean concentrations of urinary iodine in the U.S. population aged 6 years and older by gender or
race/ethnicity, National Health and Nutrition Examination Survey, 19882006.
Error bars represent 95% confidence intervals. Within a demographic group, bars not sharing a common letter differ (p < 0.05).
Detailed Observations
The selected observations mentioned below are derived from the uncorrected tables and figures
presented next. The NHANES population is of sufficient size to allow group comparisons based
on uncorrected data. Statements about categorical differences between demographic groups noted
below are based on non-overlapping confidence limits from univariate analysis without adjusting
for demographic variables (i.e., age, sex, race/ethnicity) or other determinants of these urine
concentrations (i.e., dietary intake, supplement usage, smoking, BMI). A multivariate analysis may
alter the size and statistical significance of these categorical differences. Furthermore, additional
significant differences of smaller magnitude may be present despite their lack of mention here (e.g.,
if confidence limits slightly overlap or if differences are not statistically significant before covariate
adjustment has occurred). For a selection of citations of descriptive NHANES papers related to
these biochemical indicators of diet and nutrition, see Appendix G.
345
346
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Race/ethnicity
173
141
159
174
140
Males
Females
Gender
222
179
135
137
187
156
611 years
1219 years
2039 years
4059 years
60 years and older
Age group
Total
(161 185)
(131 151)
(151 168)
(164 185)
(133 147)
(201 245)
(161 199)
(126 144)
(128 147)
(170 205)
(148 163)
30.7
28.7
22.5
28.0
20.0
36.4
24.9
20.0
20.0
30.3
23.3
(19.0 38.6)
(25.7 30.8)
(18.9 25.8)
(22.4 32.9)
(17.5 24.0)
(25.8 43.0)
(18.0 30.8)
(17.6 23.8)
(13.2 26.0)
(25.9 37.7)
(19.4 26.0)
40.2
38.2
32.0
38.1
28.5
51.6
36.7
29.4
28.4
41.9
33.0
(34.0 49.4)
(31.1 44.0)
(27.9 36.6)
(34.9 42.5)
(24.0 32.0)
(37.5 55.9)
(25.0 45.7)
(22.5 33.6)
(21.5 35.2)
(36.9 49.0)
(29.0 36.5)
186
141
166
180
144
232
186
140
145
181
162
(173 195)
(128 152)
(156 176)
(172 189)
(137 153)
(208 270)
(171 203)
(129 149)
(136 156)
(168 202)
(154 170)
591
482
634
673
571
764
741
515
489
707
603
(539 730)
(442 554)
(570 714)
(581 760)
(541 606)
(631 1,080)
(644 903)
(453 614)
(457 574)
(616 1,080)
(565 676)
768
606
835
935
762
1,040
936
679
674
1,530
816
(687 1,130)
(535 770)
(731 1,170)
(743 1,260)
(664 953)
(756 6,960)
(808 1,240)
(599 872)
(556 906)
(1,050 4,320)
(719 1,040)
1,320
1,363
2,085
2,477
2,698
666
1,443
1,134
919
1,013
5,175
Geometric mean and selected percentiles of urine concentrations (in ng/mL) for the total U.S. population aged 6 years and older, National Health
and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
100
200
300
Females
Males
Urinary iodine
(ng/mL)
400
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
300
200
100
0
Urinary iodine
(ng/mL)
400
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
100
200
300
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary iodine
(ng/mL)
400
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
3. Trace Elements
347
156
222
179
135
137
187
(148 163)
(201 245)
(161 199)
(126 144)
(128 147)
(170 205)
47.9
77.6
55.5
42.0
40.4
61.3
(42.9 53.9)
(55.8 94.7)
(44.3 68.0)
(33.9 52.9)
(36.9 45.7)
(52.0 68.5)
162
232
186
140
145
181
(154 170)
(208 270)
(171 203)
(129 149)
(136 156)
(168 202)
444
581
518
368
388
523
(422 467)
(515 754)
(465 658)
(323 416)
(359 423)
(463 580)
5,175
666
1,443
1,134
919
1,013
174
250
200
154
149
211
(164 185)
(212 295)
(181 222)
(142 167)
(137 163)
(191 233)
56.4
94.3
73.1
53.6
48.3
65.1
(48.0 65.2)
(55.4 115)
(54.8 87.7)
(38.8 65.1)
(38.6 59.5)
(46.9 88.2)
180
264
198
160
148
205
(172 189)
(212 313)
(184 220)
(143 174)
(138 166)
(193 228)
465
653
525
408
395
538
(441 500)
(498 1,080)
(479 707)
(327 478)
(363 458)
(469 652)
2,477
307
693
512
454
511
140
195
160
118
127
169
(133 147)
(176 215)
(137 186)
(107 131)
(116 139)
(151 189)
41.4
61.8
46.1
35.4
36.4
60.2
(37.7 46.8)
(45.8 81.5)
(29.2 59.0)
(30.4 43.8)
(28.2 40.1)
(48.9 67.7)
144
210
166
119
140
157
(137 153)
(174 232)
(143 191)
(108 136)
(123 161)
(134 176)
412
549
487
333
368
483
(389 453)
(423 718)
(421 633)
(300 406)
(333 418)
(413 590)
2,698
359
750
622
465
502
Males
Females
173
223
174
169
151
175
(161 185)
(196 253)
(155 194)
(153 186)
(124 184)
(148 207)
59.9
80.8
56.6
65.7
45.4
57.2
(52.3 68.3)
(54.8 98.9)
(44.9 62.7)
(55.6 78.5)
(33.9 59.5)
(43.7 69.2)
186
235
176
187
158
159
(173 195)
(208 265)
(163 203)
(165 198)
(123 196)
(128 193)
450
544
488
401
382
444
173
224
194
167
139
196
(162 185)
(187 269)
(164 230)
(148 189)
(112 171)
(166 232)
61.8
85.2
60.8
62.3
45.1
70.5
(56.1 71.9)
(41.0 133)
(46.1 78.1)
(58.5 78.1)
(31.2 61.1)
(30.1 92.3)
184
236
199
184
122
196
(165 199)
(209 271)
(169 234)
(146 202)
(107 168)
(155 243)
454
519
549
386
369
495
(404 510)
(422 836)
(432 747)
(334 591)
(298 1,260)
(365 6,920)
623
96
221
134
77
95
172
221
154
171
165
159
(159 187)
(182 269)
(134 178)
(148 198)
(128 212)
(117 218)
57.0
75.9
49.4
68.9
45.9
52.5
(45.9 67.4)
(47.0 94.8)
(34.7 61.1)
(39.1 81.4)
(20.2 64.8)
(34.2 61.4)
190
226
163
187
199
128
(164 205)
(180 270)
(142 188)
(145 219)
(145 218)
(107 163)
444
584
428
402
385
425
(373 566)
(456 1,110)
(338 695)
(348 569)
(295 1,150)
(283 1,010,900)
697
121
245
149
88
94
Males
Females
(404 518)
(469 713)
(414 596)
(352 547)
(305 699)
(377 690)
1,320
217
466
283
165
189
348
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
141
186
149
128
140
128
(131 151)
(163 213)
(137 163)
(113 145)
(124 160)
(108 151)
51.7
62.4
55.0
57.3
48.3
42.1
(47.6 57.0)
(45.7 76.1)
(47.9 61.0)
(47.2 66.3)
(35.7 59.1)
(35.0 50.6)
141
190
148
125
134
128
(128 152)
(168 217)
(138 168)
(116 160)
(122 144)
(102 146)
374
459
394
283
428
326
158
208
161
141
161
145
(145 172)
(172 251)
(145 178)
(125 160)
(134 192)
(105 200)
58.1
75.9
61.4
61.0
55.5
42.6
(51.7 69.8)
(48.1 102)
(47.3 76.3)
(46.8 72.0)
(34.1 77.7)
(31.1 55.9)
159
205
155
154
145
141
(142 176)
(172 284)
(141 177)
(117 185)
(125 198)
(93.6 204)
408
500
409
292
429
414
(335 456)
(393 952)
(342 588)
(259 398)
(329 518)
(249 8,300)
663
106
260
108
104
85
127
166
139
118
125
116
(117 138)
(145 190)
(124 156)
(98.4 142)
(107 147)
(91.7 148)
49.0
44.7
50.9
54.2
44.8
42.0
(41.9 53.8)
(39.2 67.1)
(36.2 59.2)
(27.1 66.6)
(30.9 53.4)
(12.9 50.6)
128
168
139
123
122
115
(121 136)
(151 211)
(125 164)
(105 148)
(103 137)
(83.6 146)
329
409
387
237
390
271
(307 380)
(381 581)
(312 475)
(212 342)
(290 516)
(244 466)
700
115
255
130
115
85
Males
Females
(322 423)
(387 682)
(351 475)
(242 310)
(337 485)
(259 529)
1,363
221
515
238
219
170
159
237
187
133
140
193
(151 168)
(208 271)
(160 218)
(122 145)
(131 151)
(175 214)
47.0
81.0
48.9
39.9
40.3
65.3
(41.1 54.3)
(55.0 103)
(36.7 73.4)
(32.0 49.0)
(35.6 48.7)
(55.5 74.1)
166
267
194
139
153
193
(156 176)
(202 315)
(172 224)
(125 150)
(139 167)
(172 211)
461
620
561
378
389
538
182
292
213
159
153
220
(170 195)
(230 371)
(185 246)
(141 179)
(140 168)
(198 245)
58.0
112
77.2
51.0
49.7
66.6
(47.5 69.5)
(46.9 132)
(38.8 102)
(36.9 71.6)
(38.4 65.5)
(45.4 93.4)
187
315
208
163
153
218
(176 199)
(229 381)
(187 242)
(139 186)
(137 173)
(197 249)
481
741
564
413
396
548
(450 548)
(503 1,600)
(483 770)
(322 516)
(355 464)
(483 666)
141
191
162
112
129
174
(132 149)
(166 221)
(127 206)
(98.2 129)
(117 143)
(153 197)
39.6
58.9
36.9
32.3
33.6
63.3
(33.9 44.0)
(38.5 81.6)
(18.6 58.0)
(22.5 41.6)
(24.7 40.7)
(50.0 72.8)
148
194
171
115
150
166
(137 157)
(150 251)
(138 227)
(102 130)
(123 178)
(137 191)
423
554
538
327
368
482
(390 471)
(423 855)
(431 793)
(278 461)
(334 425)
(401 613)
Males
Females
(427 489)
(536 978)
(481 744)
(318 461)
(361 424)
(460 598)
2,085
169
365
494
453
604
996
76
174
211
229
306
1,089
93
191
283
224
298
3. Trace Elements
349
162
150
161
(152 172)
(141 160)
(150 174)
30.1
28.9
36.0
(24.9 35.5)
(24.9 33.7)
(29.0 39.1)
168
160
164
(158 177)
(146 172)
(154 174)
713
569
665
(627 809)
(493 660)
(580 762)
235
209
235
(208 266)
(183 239)
(201 276)
51.8
45.7
60.2
(25.5 65.9)
(37.4 54.0)
(28.0 80.9)
249
229
238
(220 288)
(187 279)
(197 279)
771
613
967
(700 918)
(553 1,180)
(673 2,950)
374
315
351
20012002
20032004
20052006
192
166
193
(178 207)
(141 195)
(167 224)
38.3
33.5
38.2
(23.5 47.2)
(17.9 46.4)
(25.1 51.8)
205
178
194
(189 214)
(144 203)
(177 224)
803
645
797
(710 968)
(503 924)
(713 1,160)
831
721
722
20012002
20032004
20052006
148
138
132
(132 166)
(125 151)
(120 145)
27.8
23.8
31.9
(22.0 40.6)
(18.5 32.3)
(22.3 40.0)
153
146
134
(136 173)
(123 165)
(124 143)
536
564
483
(473 762)
(446 746)
(412 601)
627
517
617
20012002
20032004
20052006
140
132
143
(121 162)
(119 147)
(129 158)
24.5
24.9
34.6
(21.1 30.0)
(13.1 35.0)
(20.1 38.3)
141
142
148
(119 169)
(128 161)
(131 173)
689
478
519
(525 1,330)
(422 690)
(431 640)
496
434
485
20012002
20032004
20052006
177
169
205
(156 200)
(152 189)
(175 240)
40.7
39.7
47.9
(30.1 48.7)
(29.9 45.9)
(35.6 59.7)
171
170
195
(152 198)
(148 196)
(172 223)
744
635
826
(617 1,250)
(518 776)
(620 4,220)
509
539
474
20012002
20032004
20052006
192
169
179
(178 208)
(156 183)
(163 197)
41.7
38.8
38.0
(35.0 48.0)
(25.9 44.3)
(32.9 44.8)
196
178
182
(179 209)
(164 193)
(172 195)
769
584
702
(630 981)
(475 786)
(595 960)
1,333
1,229
1,248
20012002
20032004
20052006
137
134
146
(127 148)
(125 145)
(136 158)
24.6
25.0
31.2
(21.3 29.2)
(23.0 29.0)
(20.6 39.0)
140
141
147
(126 156)
(127 155)
(137 155)
653
559
592
(576 736)
(493 584)
(544 693)
1,504
1,297
1,401
20012002
20032004
20052006
176
168
177
(163 189)
(152 187)
(161 195)
33.7
38.7
44.6
(29.0 42.3)
(19.9 52.0)
(34.7 54.0)
187
186
184
(168 206)
(166 194)
(165 210)
673
568
640
(527 883)
(444 1,020)
(531 1,030)
720
617
703
20012002
20032004
20052006
156
134
147
(137 178)
(120 149)
(133 163)
38.6
42.3
34.3
(30.6 45.7)
(33.6 44.9)
(27.8 42.0)
143
131
149
(124 172)
(121 146)
(137 164)
716
456
510
(608 918)
(386 599)
(440 678)
670
634
729
20012002
20032004
20052006
163
154
165
(150 176)
(144 164)
(151 180)
29.2
28.8
35.3
(22.7 35.6)
(23.9 33.8)
(26.3 39.1)
169
166
166
(160 181)
(151 181)
(154 179)
734
572
678
(604 875)
(486 684)
(583 831)
1,222
1,080
1,005
Age group
611 years
20012002
20032004
20052006
1219 years
2039 years
4059 years
Gender
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
350
2,837
2,526
2,649
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
3000
95th Percentile
2000
1000
j
j
j
j
j
j
j
j
j
0
300
50th Percentile
250
j
j
200
j
j
j
150
j
j
j
j
100
100
60
j
j
j
40
j
j
j
j
j
j
20
Females
MA
0102
0304
0506
Males
0102
0304
0506
20+y
0102
0304
0506
1219y
0102
0304
0506
611y
0102
0304
0506
35y
0102
0304
0506
0102
0304
0506
Total
(6+y)
0102
0304
0506
0102
0304
0506
0
0102
0304
0506
5th Percentile
80
NHB
NHW
3. Trace Elements
351
352
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
160
98.6
167
145
165
269
134
119
145
224
155
(151 170)
(91.2 106)
(161 174)
(137 153)
(156 174)
(244 297)
(124 145)
(111 127)
(136 156)
(209 241)
(147 163)
46.2
29.1
45.0
37.5
42.1
73.3
38.4
35.2
39.9
60.9
39.3
(42.1 49.9)
(25.8 30.7)
(41.4 46.9)
(35.0 39.6)
(37.8 45.4)
(56.4 81.6)
(35.1 42.1)
(32.5 38.8)
(34.1 42.0)
(53.6 65.5)
(37.1 41.7)
54.1
33.1
53.2
44.9
49.7
84.3
45.4
40.4
45.7
67.9
46.7
(50.2 58.7)
(30.4 34.6)
(48.7 57.4)
(41.2 47.7)
(45.4 55.6)
(77.6 92.2)
(41.0 49.7)
(37.5 44.9)
(41.2 50.6)
(65.6 71.0)
(44.7 50.0)
156
90.4
158
138
157
266
125
111
146
214
149
(146 163)
(83.4 99.1)
(151 169)
(129 149)
(148 169)
(240 293)
(115 137)
(103 119)
(132 158)
(191 237)
(140 156)
494
360
602
523
617
840
473
392
482
727
572
(470 617)
(325 395)
(539 669)
(479 591)
(558 693)
(653 1,190)
(406 555)
(347 485)
(421 526)
(660 891)
(525 628)
695
493
819
642
807
1,150
616
557
600
1,320
763
(588 1,060)
(437 588)
(697 1,060)
(584 1,140)
(716 944)
(827 7,820)
(528 835)
(450 903)
(519 738)
(863 5,710)
(663 932)
1,319
1,363
2,085
2,477
2,697
666
1,442
1,134
919
1,013
5,174
Geometric mean and selected percentiles of urine concentrations (in g/g creatinine) for the total U.S. population aged 6 years and older, National
Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
(95% conf. interval)
size
Mexican Americans
400
100
200
300
Females
Males
Urinary iodine
(g/g creatinine)
500
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
400
300
200
100
0
Urinary iodine
(g/g creatinine)
500
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
400
100
200
300
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary iodine
(g/g creatinine)
500
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
3. Trace Elements
353
155
269
134
119
145
224
(147 163)
(244 297)
(124 145)
(111 127)
(136 156)
(209 241)
59.8
105
55.9
50.5
58.4
83.6
(56.4 64.0)
(92.1 115)
(49.7 61.9)
(46.7 55.0)
(50.9 63.7)
(75.9 92.3)
149
266
125
111
146
214
(140 156)
(240 293)
(115 137)
(103 119)
(132 158)
(191 237)
410
631
346
289
357
552
(391 438)
(590 820)
(301 386)
(271 324)
(322 408)
(481 635)
5,174
666
1,442
1,134
919
1,013
145
283
134
114
129
198
(137 153)
(248 323)
(122 148)
(106 123)
(119 140)
(183 215)
56.5
108
52.4
50.3
52.1
73.1
(52.3 60.2)
(83.8 131)
(46.2 58.2)
(44.9 54.6)
(45.8 60.0)
(67.3 83.9)
138
280
132
103
126
180
(129 149)
(245 322)
(117 149)
(93.8 114)
(113 136)
(168 205)
382
631
347
276
311
440
(357 414)
(589 1,060)
(300 413)
(264 335)
(274 392)
(407 481)
2,477
307
693
512
454
511
165
256
134
123
162
247
(156 174)
(228 286)
(121 148)
(112 136)
(148 178)
(224 272)
63.9
99.9
59.3
51.0
63.8
92.2
(57.9 69.6)
(87.8 114)
(51.3 64.9)
(45.8 57.9)
(55.7 70.9)
(79.1 104)
157
247
121
118
166
243
(148 169)
(227 293)
(111 131)
(107 130)
(145 188)
(221 262)
439
630
332
292
408
617
(403 481)
(529 821)
(292 403)
(254 359)
(344 482)
(554 696)
2,697
359
749
622
465
502
Males
Females
160
276
146
137
146
222
(151 170)
(246 311)
(131 163)
(125 149)
(129 164)
(193 255)
67.5
123
61.9
59.7
66.0
85.2
(60.4 70.6)
(103 138)
(53.6 72.7)
(53.7 71.1)
(55.3 69.3)
(67.8 101)
156
267
143
137
148
210
(146 163)
(242 293)
(128 157)
(120 147)
(124 161)
(167 247)
383
619
344
293
317
459
148
269
147
124
133
189
(137 159)
(236 307)
(125 173)
(111 139)
(111 160)
(167 213)
60.0
126
58.5
55.7
58.9
81.1
(56.3 65.7)
(81.6 166)
(46.3 72.5)
(46.1 64.8)
(40.2 67.6)
(67.3 99.9)
147
278
141
121
136
168
(131 163)
(226 318)
(121 168)
(109 146)
(101 161)
(144 204)
361
541
346
244
318
410
(319 428)
(454 725)
(282 519)
(220 435)
(285 383)
(319 1,020)
623
96
221
134
77
95
174
284
145
153
160
253
(164 186)
(237 340)
(129 162)
(139 168)
(141 182)
(204 315)
73.4
116
67.1
73.4
68.0
86.1
(67.6 78.3)
(101 134)
(55.5 74.4)
(51.7 84.7)
(59.1 82.3)
(23.2 124)
162
250
144
143
160
232
(156 177)
(224 299)
(123 157)
(125 162)
(141 181)
(196 265)
416
656
333
344
308
502
(352 488)
(468 2,530)
(267 492)
(293 446)
(264 434)
(415 2,790)
696
121
244
149
88
94
Males
Females
(343 470)
(468 925)
(285 468)
(261 384)
(292 382)
(385 725)
1,319
217
465
283
165
189
354
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
98.6
188
90.8
75.5
98.3
123
(91.2 106)
(164 214)
(83.6 98.6)
(67.9 83.9)
(88.0 110)
(106 143)
39.0
80.2
40.5
35.6
38.1
46.0
(35.8 41.7)
(67.6 87.6)
(36.5 42.5)
(31.1 38.6)
(32.9 45.4)
(40.3 50.9)
90.4
180
87.0
72.6
90.5
108
(83.4 99.1)
(152 221)
(78.8 95.5)
(63.6 80.4)
(78.2 103)
(98.4 129)
264
448
223
209
257
337
101
187
90.1
76.2
105
123
(90.7 112)
(152 231)
(81.4 99.7)
(67.5 85.9)
(87.6 126)
(89.2 170)
37.6
73.7
37.4
35.3
34.3
41.0
(33.7 41.2)
(52.4 87.7)
(31.5 41.8)
(27.7 38.4)
(29.7 47.5)
(34.7 49.6)
92.1
178
84.8
71.7
93.8
103
(80.8 103)
(142 244)
(75.5 97.0)
(62.5 78.5)
(73.4 130)
(78.5 159)
294
447
224
215
286
365
(254 360)
(360 898)
(196 264)
(127 285)
(239 559)
(242 4,440)
663
106
260
108
104
85
96.5
188
91.5
74.9
92.9
123
(89.3 104)
(167 211)
(82.1 102)
(64.2 87.5)
(83.6 103)
(99.9 152)
39.3
83.8
42.8
36.1
39.5
50.2
(35.7 44.7)
(68.1 98.7)
(36.5 46.2)
(30.0 39.1)
(29.3 47.1)
(30.9 61.9)
89.3
185
88.5
72.7
88.5
111
(84.3 97.6)
(152 220)
(76.0 99.7)
(60.5 84.3)
(73.7 99.0)
(97.1 134)
247
442
205
196
217
255
(218 285)
(375 548)
(164 311)
(130 248)
(196 284)
(229 540)
700
115
255
130
115
85
Males
Females
(248 293)
(376 558)
(191 258)
(137 254)
(217 296)
(251 498)
1,363
221
515
238
219
170
167
299
147
125
155
236
(161 174)
(261 342)
(134 161)
(118 133)
(145 166)
(218 256)
67.2
114
63.3
55.5
62.7
94.3
(63.6 69.2)
(92.8 132)
(54.3 69.8)
(47.8 62.1)
(56.4 69.7)
(82.5 102)
158
289
135
115
155
233
(151 169)
(259 348)
(122 155)
(107 124)
(140 174)
(196 248)
430
663
374
298
364
559
(404 472)
(616 1,050)
(311 447)
(274 345)
(327 419)
(481 657)
2,085
169
365
494
453
604
157
337
149
122
137
208
(149 165)
(272 417)
(135 163)
(111 135)
(126 149)
(192 226)
64.0
131
59.4
57.5
59.3
82.9
(61.1 67.2)
(63.9 170)
(49.6 67.3)
(46.5 65.4)
(48.9 64.1)
(70.7 95.2)
150
326
143
104
136
189
(140 156)
(268 429)
(129 170)
(93.8 122)
(120 152)
(173 215)
396
811
378
292
313
440
(368 428)
(610 2,040)
(301 455)
(265 349)
(274 414)
(402 522)
996
76
174
211
229
306
178
265
145
128
175
261
(169 188)
(225 311)
(127 167)
(116 142)
(159 193)
(232 294)
70.6
99.1
65.0
51.3
70.6
104
(64.9 74.3)
(84.0 118)
(56.0 74.0)
(45.4 62.5)
(58.0 79.3)
(81.2 119)
169
262
127
123
179
255
(156 183)
(227 315)
(112 152)
(110 141)
(152 202)
(236 280)
464
640
368
295
433
630
(431 514)
(474 1,020)
(292 499)
(242 391)
(362 496)
(556 697)
1,089
93
191
283
224
298
Males
Females
3. Trace Elements
355
163
146
163
(153 173)
(135 158)
(153 175)
50.0
45.4
50.0
(46.8 54.0)
(39.4 49.3)
(45.0 54.7)
151
142
155
(141 165)
(130 154)
(143 169)
620
492
620
(567 687)
(449 585)
(549 733)
20012002
20032004
20052006
273
254
286
(246 304)
(228 283)
(242 339)
94.5
84.4
82.5
(75.7 106)
(71.9 98.7)
(64.3 98.9)
257
246
288
(220 319)
(233 269)
(236 362)
923
718
947
(772 1,140)
(615 1,210)
(654 2,300)
374
315
351
20012002
20032004
20052006
149
124
145
(137 161)
(109 141)
(130 162)
52.5
45.4
45.4
(47.8 58.9)
(36.3 49.9)
(39.8 51.9)
138
117
138
(129 146)
(104 132)
(117 163)
601
381
477
(450 721)
(314 532)
(434 829)
830
720
722
20012002
20032004
20052006
135
115
123
(127 143)
(104 127)
(112 135)
46.7
39.2
43.9
(42.2 49.5)
(33.9 44.9)
(39.1 49.0)
128
108
114
(118 136)
(99.3 119)
(97.7 131)
470
407
378
(443 577)
(319 559)
(339 592)
627
517
617
20012002
20032004
20052006
151
138
152
(130 175)
(126 152)
(137 170)
44.7
42.0
47.0
(37.9 54.5)
(34.9 49.9)
(40.9 56.5)
142
136
153
(120 176)
(126 150)
(126 179)
522
436
492
(427 712)
(392 561)
(429 544)
496
434
485
20012002
20032004
20052006
216
204
246
(192 244)
(188 222)
(218 277)
67.1
67.2
68.4
(51.2 75.5)
(60.3 74.0)
(65.8 72.8)
199
197
235
(179 230)
(178 233)
(193 256)
751
595
858
(632 1,000)
(521 726)
(697 5,190)
508
539
474
20012002
20032004
20052006
156
137
152
(143 171)
(127 148)
(140 165)
47.0
41.7
47.8
(43.7 51.1)
(36.3 46.4)
(42.6 50.4)
145
132
147
(137 160)
(121 146)
(132 158)
578
481
540
(514 674)
(417 590)
(480 795)
1,333
1,229
1,248
20012002
20032004
20052006
170
155
176
(161 179)
(142 169)
(163 189)
55.2
46.9
54.4
(48.0 57.1)
(41.8 52.7)
(44.6 60.3)
158
151
164
(146 168)
(133 167)
(150 179)
670
532
687
(585 748)
(452 630)
(598 829)
1,502
1,296
1,401
20012002
20032004
20052006
164
152
167
(152 176)
(138 169)
(154 181)
56.0
51.3
56.2
(49.4 61.0)
(42.1 58.9)
(51.7 60.0)
154
147
163
(140 177)
(133 164)
(153 179)
589
481
544
(469 754)
(389 1,100)
(454 728)
720
616
703
20012002
20032004
20052006
113
92.1
105
(103 124)
(81.2 104)
(96.7 115)
36.8
33.1
33.7
(27.9 42.8)
(29.7 33.8)
(29.8 37.7)
103
84.6
96.6
(93.5 115)
(73.1 97.6)
(87.0 111)
440
336
397
(361 645)
(296 375)
(315 513)
669
634
729
20012002
20032004
20052006
175
159
177
(163 188)
(150 168)
(166 188)
55.1
50.9
55.0
(48.3 58.2)
(46.3 58.2)
(45.8 59.4)
164
153
168
(151 176)
(147 161)
(152 179)
652
526
656
(576 749)
(442 621)
(561 868)
1,221
1,080
1,005
Age group
611 years
1219 years
2039 years
4059 years
Gender
2,835
2,525
2,649
Males
Females
Race/ethnicity
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
356
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2500
95th Percentile
2000
1500
1000
1
1
1
500
1
1
1
1
1
0
400
50th Percentile
300
1
1
200
1
1
1
1
1
1
1
1
1
1
1
100
0
120
100
1
80
60
1
1
1
1
1
40
1
1
1
1
1
0102
0304
0506
0102
0304
0506
Males
Females
0102
0304
0506
20+y
0102
0304
0506
1219y
0102
0304
0506
611y
0102
0304
0506
35y
0102
0304
0506
Total
(6+y)
0102
0304
0506
0102
0304
0506
20
0102
0304
0506
5th Percentile
MA
NHB
NHW
3. Trace Elements
357
References
Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, et al. Management of thyroid
dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin
Endocrinol & Metabol. 2007;92:s1s47.
Andersen S, Karmisholt J, Pdersen KM, Laurberg P. Reliability of studies of iodine intake and recommendations
for number of samples in groups and in individuals. Br J Nutr. 2008;99:813818.
Andersson M, de Benoist B, Delange F, Zupan J. Prevention and control of iodine deficiency in pregnant and
lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical
Consultation. Public Health Nutrition 2007;10(12A):16061611.
Becker DV, Braverman LE, Delange F, Dunn JT, Franklyn JA, Hollowell JG, et al. Iodine supplementation for
pregnancy and lactationUnited States and Canada: recommendations of the American Thyroid Association.
Thyroid. 2006;16:949951.
Beers MH, editor. Vitamin deficiency, dependency, and toxicity. In: Merck Manual of Diagnosis and Therapy. 18th
ed. Whitehouse Station (NJ): Merck & Co., Inc.; 2006 [cited 2011]. Available at: http://www.merckmanuals.com/
professional/sec01/ch005/ch005e.html.
Caldwell KL, Maxwell B, Makhmudov A, Pino S, Braverman LE, Jones RL, et al. Use of inductively coupled
plasma mass spectrometry to measure urinary iodine in NHANES 2000: comparison with previous method. Clin
Chem. 2003;49:10191021.
Caldwell KL, Jones R, Hollowell JG. Urinary iodine concentration: United States National Health and Nutrition
Examination Survey 20012002. Thyroid. 2005;15:692699.
Caldwell KL, Miller GA, Wang RY, Jain RB, Jones RL. Iodine status of the U.S. population, National Health and
Nutrition Examination Survey 20032004. Thyroid. 2008;18:12071214.
Caldwell KL, Makhmudov A, Ely E, Jones RL, Wang R. Iodine status of the U.S. population, National Health and
Nutrition Examination Survey, 20052006 and 20072008. Thyroid. 2011;21:419427.
Glinoer D. The importance of iodine nutrition during pregnancy. Publ Health Nutr. 2007;10:15421546.
Gregory CO, Serdula MK, Sullivan KM. Use of supplements with and without iodine in women of childbearing
age in the United States. Thyroid. 2009;19:10191020.
Hollowell JG, Staehling NW, Hannon WH, Flanders DW, Gunter EW, Maberly GF, et al. Iodine nutrition in the
United States. Trends and public health implications: iodine excretion data from National Health and Nutrition
Examination Surveys I and III (19711974 and 19881994). J Clin Endocrinol Metab. 1998;83:34013408.
Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes: vitamin A, vitamin K, arsenic, boron,
chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.:
National Academy Press; 2001.
Murray CW, Egan SK, Kim H, Beru N, Bolger PM. US Food and Drug Administrations Total Diet Study: Dietary
intake of perchloriate and iodine. J Exposure Sci Environ Epidem. 2008;18:571580.
Pennington JAT, Schoen SA. Total Diet Study: estimated dietary intakes of nutritional elements, 19821991. Int J
Vit Nutr Res. 1996;66:350362.
Perrine CG, Herrick K, Serdula MK, Sullivan KM. Some subgroups of reproductive age women in the United
States may be at risk for iodine deficiency. J Nutr. 2010;140:14891494.
Pino S, Fang SL, Braverman LE. Ammonium persulfate: a new and safe method for measuring urinary iodine by
ammonium persulfate oxidation. Exp Clin Endocrinol Diabetes. 1998;106 Suppl 3:S22S27.
World Health Organization. Assessment of iodine deficiency disorders and monitoring their elimination: a guide
for programme managers. 3rd ed. Geneva (Switzerland): World Health Organization, 2007 (WHO/NHD/01.1)
[cited 2011]. Available at: http://whqlibdoc.who.int/publications/2007/9789241595827_eng.pdf.
358
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Genistein
Daidzein
Equol
O-Desmethylangolensin
Lignans
Enterodiol
Enterolactone
361
362
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
363
Biochemical Indicators and Methods. A systematic review of intervention studies has shown
that urinary concentrations of daidzein, genistein, and enterolactone are good biomarkers of
dietary intake (Pearson r = 0.780.87) as compared to equol, ODMA (0.380.40) and enterodiol
(-0.14) (Prez-Jimnez 2010). Linear dose-response relations are typically observed for the
lignans (Nesbitt 1999; Hutchins 2000). Saturation in urine recovery has been observed with the
isoflavones (Setchell 2003a). Isoflavones and lignans have been measured in biologic matrices such
as plasma, serum, and urine by use of high performance liquid chromatography (HPLC) or gas
chromatography (GC) with various modes of detection (Hoikkala 2003; Prasain 2004). Liquid
chromatography coupled to tandem mass spectrometry (LC-MS/MS) methods that measure
isoflavones and lignans concentrations after deconjugation of glucuronides and sulfates are most
commonly used at present.
Data in NHANES. Phytoestrogens have been measured in NHANES since 1999. In NHANES
19992000, CDC scientists detected enterolactone in the highest concentration, and daidzein
was detected with the highest frequency among the six measured phytoestrogens (ValentinBlasini 2005). CDCs Fourth National Report on Human Exposure to Environmental Chemicals
presented geometric means and selected percentiles (50th, 75th, 90th, and 95th) for concentrations
of phytoestrogens by age, sex, or race/ethnicity for participants in NHANES 19992000, 2001
2002, and 20032004 (U.S. Centers for Disease Control and Prevention 2009).
Urinary daidzein, genistein, equol, ODMA, enterolactone, and enterodiol data presented in this
report were generated by use of LC-MS/MS using electrospray ionization (ESI) for NHANES
20032004 (Rybak 2008) and LC-MS/MS using atmospheric pressure photoionization (APPI)
for NHANES 20052006 (Parker 2011). Crossover studies comparing samples analyzed by
LC-ESI-MS/MS and LC-APPI-MS/MS demonstrated high correlation coefficients (r >0.99) and
regression slopes approximately equal to 1 and intercepts close to 0 (U.S. Centers for Disease
Control and Prevention 2011).
For more information about soy isoflavones, see the fact sheet from the National Institutes of
Health, Office of Dietary Supplements (http://ods.od.nih.gov/Health_Information/Information_
About_Individual_Dietary_Supplements.aspx).
Highlights
Urinary isoflavone and lignan concentrations in the U.S. population showed the following
demographic patterns and characteristics:
No consistent patterns were observed with regard to age, gender, or race/ethnicity.
Concentrations have been relatively similar from 19992006.
Urinary isoflavone and lignan concentrations showed only small variations by demographic
variables, such as age, gender, or race/ethnicity, or by survey cycle. However, as reported previously
(Valentin-Blasini 2005), we observed large differences in the concentration of different urinary
phytoestrogens. The enterolactone concentration was approximately one order of magnitude
higher than the concentrations of genistein, daidzein, and enterodiol, which in turn were
approximately one order of magnitude higher than the concentrations of equol and ODMA
(Figure H.4.a). These phytoestrogens were detected in >99% of all samples, with the exception of
ODMA, which was detected in only 93% of all samples.
364
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
1000
100
10
Genistein
Daidzein
Equol
O-Desmethylangolensin
Enterodiol
Enterolactone
Figure H.4.a. Geometric mean concentrations of urinary isoflavones and lignans in the U.S. population aged 6 years and older,
National Health and Nutrition Examination Survey, 20032006.
Error bars represent 95 percent confidence intervals. The y-axis is displayed on the logarithmic scale.
Detailed Observations
The selected observations mentioned below are derived from the uncorrected tables and figures
presented next. The NHANES population is of sufficient size to allow group comparisons based
on uncorrected data. Statements about categorical differences between demographic groups
noted below are based on non-overlapping confidence limits from univariate analysis without
adjusting for demographic variables (i.e., age, sex, race/ethnicity) or other determinants of these
urine concentrations (i.e., dietary intake, supplement usage, smoking, BMI). A multivariate
analysis may alter the size and statistical significance of these categorical differences. Furthermore,
additional significant differences of smaller magnitude may be present despite their lack of
mention here (e.g., if confidence limits slightly overlap or if differences are not statistically
significant before covariate adjustment has occurred). For a selection of citations of descriptive
NHANES papers related to these biochemical indicators of diet and nutrition, see Appendix G.
365
366
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
29.3
31.8
28.8
(26.8 32.0)
(27.1 37.3)
(26.7 31.1)
(30.2 35.7)
(24.9 29.9)
(30.9 41.9)
(30.7 38.6)
(25.0 32.5)
(25.1 31.5)
(26.1 33.3)
(28.0 31.8)
1.67
1.88
1.38
1.96
1.25
3.05
2.39
1.54
1.33
1.15
1.51
(1.10 2.05)
(1.21 2.30)
(1.13 1.65)
(1.41 2.35)
(1.05 1.53)
(1.06 3.78)
(1.92 2.78)
(1.04 1.95)
(1.04 1.73)
(< LOD 1.48)
(1.24 1.78)
2.47
3.03
2.18
3.22
2.01
4.20
3.33
2.27
2.17
2.16
2.45
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
32.9
27.2
36.0
34.4
28.5
28.1
29.5
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
29.9
(1.90 3.28)
(2.34 3.53)
(1.84 2.71)
(2.55 3.62)
(1.76 2.31)
(2.59 5.15)
(2.72 3.84)
(1.68 3.27)
(1.68 2.72)
(1.41 2.69)
(2.14 2.78)
25.8
27.8
25.3
28.5
23.8
31.7
27.6
23.7
26.2
27.5
26.1
(22.2 29.0)
(23.0 34.7)
(22.3 28.3)
(25.7 32.0)
(20.8 27.0)
(26.6 35.8)
(23.6 33.2)
(20.4 27.5)
(20.7 30.2)
(22.4 31.7)
(23.8 28.5)
570
466
502
544
514
414
514
516
589
435
523
(434 695)
(387 743)
(417 589)
(461 591)
(398 618)
(357 819)
(409 651)
(412 596)
(423 703)
(341 559)
(459 578)
929
899
761
805
867
846
946
810
767
794
852
(763 1,290)
(642 1,260)
(682 1,100)
(701 1,120)
(654 1,150)
(579 2,730)
(659 1,510)
(639 1,280)
(631 1,500)
(558 2,580)
(706 1,060)
1,287
1,343
2,108
2,496
2,626
692
1,422
1,137
901
970
5,122
Geometric mean and selected percentiles of urine concentrations (in g/L) for the total U.S. population aged 6 years and older, National Health and
Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
Mexican Americans
20
40
Females
Males
Urinary genistein
(g/L)
60
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
40
20
0
Urinary genistein
(g/L)
60
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary genistein
(g/L)
60
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
367
29.9
36.0
34.4
28.5
28.1
29.5
(28.0 31.8)
(30.9 41.9)
(30.7 38.6)
(25.0 32.5)
(25.1 31.5)
(26.1 33.3)
4.18
6.11
4.87
4.25
3.76
4.09
(3.88 4.51)
(4.50 7.43)
(4.11 5.91)
(3.30 5.01)
(3.33 3.96)
(3.31 4.77)
26.1
31.7
27.6
23.7
26.2
27.5
(23.8 28.5)
(26.6 35.8)
(23.6 33.2)
(20.4 27.5)
(20.7 30.2)
(22.4 31.7)
274
276
303
237
307
244
(246 304)
(215 355)
(237 367)
(185 322)
(242 374)
(212 311)
5,122
692
1,422
1,137
901
970
32.9
34.9
37.1
32.0
32.0
31.9
(30.2 35.7)
(28.9 42.1)
(31.3 44.0)
(27.8 36.7)
(26.9 38.0)
(26.6 38.3)
4.91
6.44
5.45
4.95
4.14
4.73
(4.35 5.39)
(4.51 8.48)
(4.48 6.96)
(3.48 5.71)
(3.42 5.17)
(3.78 5.83)
28.5
29.8
31.9
25.9
29.1
28.9
(25.7 32.0)
(22.4 35.8)
(24.2 42.5)
(21.5 32.0)
(21.7 34.2)
(20.6 36.6)
301
215
261
300
324
230
(247 337)
(177 369)
(209 402)
(197 397)
(227 510)
(183 337)
2,496
340
728
499
451
478
27.2
37.2
31.7
25.5
24.9
27.7
(24.9 29.9)
(28.2 49.0)
(26.6 37.9)
(20.7 31.3)
(21.3 29.0)
(23.1 33.2)
3.73
5.55
3.85
3.81
3.14
3.34
(3.23 4.07)
(3.39 7.52)
(3.34 5.15)
(2.25 4.32)
(2.70 3.91)
(2.11 4.74)
23.8
34.9
24.3
22.1
20.4
26.6
(20.8 27.0)
(25.3 44.7)
(20.0 31.7)
(18.9 26.9)
(16.6 27.0)
(19.2 32.0)
253
278
321
208
256
243
(222 302)
(239 407)
(220 413)
(154 318)
(175 408)
(208 322)
2,626
352
694
638
450
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
29.3
32.4
35.6
26.8
29.1
25.9
(26.8 32.0)
(24.4 43.1)
(29.8 42.6)
(23.1 31.0)
(21.9 38.8)
(20.6 32.6)
4.38
5.65
5.60
4.03
4.18
3.09
(3.48 5.15)
(4.27 6.93)
(4.70 6.58)
(2.23 5.44)
(2.24 5.48)
(2.42 3.67)
25.8
27.5
30.7
21.3
27.5
29.8
(22.2 29.0)
(19.2 35.8)
(26.9 36.0)
(16.7 26.1)
(17.8 38.2)
(17.7 35.2)
301
293
315
325
253
228
(242 341)
(127 645)
(171 493)
(229 461)
(132 506)
(138 335)
1,287
231
445
282
157
172
30.9
30.5
37.0
29.0
31.4
30.0
(26.4 36.3)
(22.1 42.0)
(30.3 45.3)
(21.3 39.5)
(19.5 50.6)
(17.7 50.9)
4.76
6.04
6.17
4.54
3.89
3.47
(3.89 5.84)
(3.33 7.64)
(4.86 7.61)
(2.37 5.97)
(1.51 6.76)
(1.78 5.40)
25.9
23.1
31.6
21.0
27.8
34.5
(21.4 31.5)
(17.9 34.9)
(26.1 40.7)
(15.5 36.1)
(13.3 43.9)
(16.9 56.7)
304
212
243
331
259
178
(200 457)
(101 566)
(160 424)
(185 646)
(86.0 4,840)
(97.8 2,730)
625
112
228
117
85
83
27.5
34.6
34.2
24.4
26.9
23.0
(23.3 32.5)
(22.2 54.1)
(26.4 44.3)
(16.8 35.4)
(19.9 36.3)
(14.2 37.1)
3.76
5.17
5.03
3.41
4.15
2.53
(2.76 4.71)
(2.04 6.90)
(3.49 6.31)
(1.71 4.29)
(1.15 5.49)
(< LOD 4.40)
25.2
34.0
29.4
20.3
26.5
17.8
(19.3 31.2)
(21.2 44.3)
(19.4 38.1)
(15.3 34.0)
(18.5 43.2)
(12.5 36.4)
286
303
407
251
199
258
(206 371)
(118 2,670)
(192 554)
(97.7 827)
(79.1 832)
(108 681)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
368
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
31.8
38.4
42.7
29.0
32.2
22.9
(27.1 37.3)
(29.9 49.4)
(37.0 49.2)
(22.5 37.4)
(24.2 43.0)
(17.5 30.0)
5.01
5.60
6.66
5.04
4.30
3.42
(4.16 5.69)
(3.37 7.09)
(5.91 7.91)
(3.86 6.11)
(2.56 6.18)
(3.12 4.54)
27.8
34.7
35.3
24.7
29.9
20.6
(23.0 34.7)
(25.1 46.0)
(29.1 44.4)
(17.2 33.2)
(20.7 45.8)
(14.9 32.7)
269
311
286
198
318
171
(206 331)
(215 640)
(227 400)
(152 390)
(167 547)
(99.8 326)
1,343
207
496
249
231
160
35.4
38.5
44.5
35.4
33.1
26.7
(30.1 41.7)
(26.8 55.3)
(36.0 55.0)
(26.1 48.0)
(24.0 45.8)
(20.0 35.6)
5.67
4.06
6.90
6.47
4.50
4.67
(4.64 6.71)
(1.87 7.03)
(4.87 8.70)
(4.28 9.07)
(2.29 7.00)
(3.31 6.20)
30.4
36.7
35.4
27.4
30.7
24.1
(26.5 36.3)
(18.6 54.7)
(27.4 48.1)
(18.8 43.5)
(20.4 47.7)
(17.1 35.7)
293
360
282
310
265
145
(214 401)
(205 747)
(193 844)
(158 413)
(153 434)
(110 525)
661
99
258
116
114
74
29.1
38.4
40.9
24.6
31.5
20.8
(23.5 35.9)
(27.0 54.5)
(35.2 47.6)
(17.4 35.0)
(19.5 51.0)
(13.2 32.7)
4.46
6.52
6.54
4.47
3.75
3.22
(3.51 5.35)
(4.22 7.95)
(4.59 8.23)
(1.60 5.45)
(2.08 6.18)
(2.12 4.03)
24.9
31.4
35.2
20.2
27.6
18.2
(19.1 35.1)
(19.2 45.9)
(26.4 47.9)
(13.7 31.3)
(15.3 58.7)
(9.40 33.0)
249
272
286
165
349
170
(172 336)
(170 1,510)
(223 376)
(103 387)
(148 870)
(50.8 19,800)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
28.8
34.9
32.8
26.9
27.0
30.2
(26.7 31.1)
(28.4 42.9)
(28.4 37.9)
(22.6 32.2)
(23.4 31.1)
(26.6 34.2)
4.00
5.95
4.48
3.82
3.44
4.23
(3.69 4.23)
(4.33 7.79)
(3.60 5.63)
(2.28 4.71)
(2.90 3.98)
(3.01 5.32)
25.3
29.1
24.7
22.8
26.0
28.0
(22.3 28.3)
(22.3 41.7)
(20.4 32.0)
(19.1 27.9)
(18.7 30.3)
(22.3 32.2)
257
247
298
218
307
242
(229 302)
(179 378)
(223 368)
(163 319)
(225 421)
(211 308)
2,108
193
378
494
448
595
31.8
34.1
34.9
29.4
32.3
31.6
(28.5 35.5)
(25.0 46.4)
(27.3 44.7)
(23.6 36.6)
(26.3 39.7)
(25.7 38.8)
4.75
6.75
5.07
4.32
4.15
4.77
(4.15 5.31)
(4.40 9.87)
(4.12 7.35)
(2.26 5.49)
(3.03 5.45)
(3.79 6.83)
27.0
26.6
25.4
23.6
29.0
28.5
(22.4 31.9)
(18.1 42.0)
(19.0 41.1)
(18.7 32.9)
(21.1 37.1)
(19.5 39.4)
274
209
262
233
336
220
(227 340)
(154 400)
(205 392)
(155 418)
(225 590)
(172 341)
1,035
99
191
217
229
299
26.2
35.8
30.7
24.7
22.5
29.1
(23.4 29.2)
(25.2 50.9)
(24.1 39.0)
(19.0 32.1)
(18.4 27.4)
(24.0 35.3)
3.30
4.98
3.62
3.18
2.93
3.67
(2.72 3.94)
(1.29 7.17)
(2.73 5.14)
(1.91 4.28)
(1.90 3.80)
(1.76 5.32)
23.6
39.3
22.4
22.2
18.3
27.5
(19.4 27.3)
(20.8 54.2)
(17.2 33.7)
(16.3 29.1)
(14.9 26.8)
(21.6 32.3)
243
271
311
210
232
244
(207 306)
(153 919)
(207 416)
(149 353)
(154 472)
(197 336)
1,073
94
187
277
219
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
369
24.4
33.0
31.1
28.7
(19.7 30.3)
(30.1 36.2)
(29.0 33.3)
(25.8 32.0)
< LOD
2.64
2.63
2.33
(2.24 2.89)
(1.99 3.28)
(1.93 2.74)
27.0
28.9
26.2
25.9
(22.5 32.4)
(26.8 31.7)
(23.8 29.6)
(20.9 29.6)
563
619
525
522
(437 727)
(536 720)
(411 619)
(438 590)
27.6
39.2
33.6
38.6
(21.1 36.1)
(33.4 46.0)
(27.8 40.6)
(29.8 49.9)
43.7
34.1
34.7
34.1
2,557
2,794
2,594
2,528
.922
5.09
4.40
3.84
31.7
31.5
29.2
34.3
(18.4 42.6)
(25.8 39.2)
(22.9 37.8)
(25.3 42.4)
376
501
351
625
(287 712)
(329 1,150)
(220 433)
(402 2,960)
331
396
341
351
(34.2 55.7)
(27.2 42.8)
(29.3 41.0)
(28.8 40.5)
2.85
3.70
3.24
3.35
(1.97 4.17)
(2.00 5.17)
(2.06 4.10)
(2.39 4.19)
44.9
29.0
29.0
26.7
(34.5 59.5)
(26.0 32.8)
(23.3 37.4)
(20.5 35.4)
543
469
522
481
(363 842)
(380 708)
(367 675)
(404 1,070)
754
744
729
693
28.7
34.4
29.1
27.9
(21.7 37.8)
(28.2 41.9)
(24.5 34.6)
(22.7 34.4)
< LOD
2.42
2.41
2.16
(1.37 3.16)
(1.40 3.83)
(1.42 3.27)
28.5
30.4
24.9
22.3
(23.2 35.8)
(25.3 38.5)
(21.0 29.6)
(18.6 29.0)
704
611
436
556
(453 1,540)
(489 797)
(396 567)
(412 938)
536
604
554
583
15.5
32.9
32.4
24.5
(10.1 23.7)
(27.6 39.4)
(27.6 38.1)
(20.8 29.0)
< LOD
2.74
2.44
2.06
(.916 3.38)
(1.75 3.38)
(1.14 2.70)
21.3
29.3
27.3
24.9
(13.0 28.2)
(24.3 34.7)
(20.8 33.1)
(17.5 30.1)
464
719
664
466
(313 1,320)
(541 1,210)
(535 1,110)
(348 637)
420
531
452
449
21.7
26.7
28.6
30.3
(16.9 27.9)
(21.8 32.7)
(24.2 33.9)
(25.2 36.5)
< LOD
1.94
2.13
2.18
(1.26 2.56)
(1.26 2.66)
(1.17 3.21)
22.5
25.0
25.9
28.8
(17.7 30.3)
(20.0 32.2)
(20.1 34.2)
(22.1 33.0)
352
496
386
469
(279 904)
(280 1,240)
(314 575)
(318 867)
516
519
518
452
29.8
32.2
33.7
32.0
(22.2 40.0)
(27.9 37.2)
(29.6 38.4)
(28.6 36.0)
< LOD
2.61
3.33
2.83
(1.94 3.33)
(2.46 4.18)
(2.34 3.45)
31.8
29.3
27.3
29.1
(26.4 37.0)
(25.6 33.7)
(23.8 33.0)
(23.0 33.8)
684
474
561
488
(441 1,440)
(348 727)
(444 655)
(411 622)
1,222
1,375
1,244
1,252
20.3
33.7
28.7
25.9
(17.0 24.2)
(30.9 36.8)
(25.5 32.4)
(22.3 29.9)
< LOD
2.62
2.05
1.93
(2.25 2.87)
(1.71 2.65)
(1.58 2.34)
23.1
28.6
25.0
22.3
(20.2 26.2)
(26.3 31.9)
(22.5 28.4)
(17.8 27.4)
442
663
466
524
(345 674)
(602 811)
(362 621)
(413 694)
1,335
1,419
1,350
1,276
31.1
28.3
31.1
27.6
(25.1 38.5)
(22.0 36.4)
(27.5 35.2)
(24.4 31.2)
.628
2.80
3.38
2.11
30.0
25.4
25.2
26.3
(25.2 37.4)
(19.9 32.4)
(19.2 32.2)
(21.7 29.8)
572
423
643
412
(471 1,550)
(340 543)
(566 865)
(333 626)
819
679
653
634
26.5
37.9
32.6
31.0
(19.0 36.9)
(27.3 52.6)
(24.2 44.0)
(26.7 36.1)
< LOD
2.49
3.00
3.00
(1.53 4.06)
(2.00 4.16)
(2.16 3.55)
32.8
35.9
27.7
27.8
(24.6 41.4)
(23.9 51.2)
(19.4 44.9)
(23.1 34.9)
456
598
506
452
(363 766)
(446 1,300)
(334 875)
(372 883)
597
692
681
662
23.7
30.9
30.9
26.9
(19.1 29.4)
(27.7 34.3)
(28.4 33.6)
(23.6 30.6)
< LOD
2.43
2.34
2.10
(2.03 2.75)
(1.71 3.29)
(1.58 2.57)
25.6
27.3
26.2
23.7
(22.0 32.0)
(24.5 30.7)
(22.8 30.9)
(19.0 29.0)
564
623
501
500
(413 742)
(521 746)
(384 619)
(397 623)
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
901
1,211
1,069
1,039
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
370
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
2000
1000
H
H
H
H
H
H
H
H
H
H
H
0
60
50th Percentile
50
H
40
H
H
H
30
H
H
H
H
H
H
H
20
10
8
H
H
H
H
H
H
H
H
H
H
H
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
371
372
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
26.4
22.3
29.3
(24.2 28.8)
(19.6 25.5)
(27.3 31.4)
(24.0 28.3)
(28.3 34.1)
(33.7 45.1)
(23.0 28.5)
(21.8 27.1)
(25.2 32.1)
(31.4 38.0)
(26.9 30.2)
1.87
2.02
2.21
2.12
2.35
3.68
2.25
2.14
1.89
2.97
2.22
(1.19 2.49)
(1.38 2.51)
(1.84 2.54)
(1.80 2.48)
(1.97 2.77)
(1.15 4.62)
(1.60 2.74)
(1.81 2.43)
(1.35 2.35)
(< LOD 3.38)
(1.97 2.46)
2.97
2.76
3.08
3.03
3.20
5.09
3.36
2.81
2.66
3.82
3.14
(2.24 3.47)
(2.31 3.16)
(2.67 3.58)
(2.60 3.42)
(2.80 3.76)
(3.51 6.16)
(2.73 3.66)
(2.37 3.50)
(2.10 3.14)
(3.36 4.47)
(2.83 3.45)
22.4
19.1
24.9
22.1
25.8
34.5
20.4
20.7
23.6
28.6
23.8
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
26.1
31.1
39.0
25.6
24.3
28.4
34.5
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
28.5
(19.5 24.6)
(15.7 22.2)
(22.1 27.7)
(19.5 24.9)
(22.9 28.1)
(27.4 38.3)
(17.8 24.8)
(17.8 23.6)
(19.1 27.8)
(24.5 32.6)
(21.6 26.1)
441
319
594
422
617
626
367
355
645
576
534
(355 656)
(261 488)
(437 687)
(348 557)
(448 778)
(412 1,060)
(293 440)
(291 530)
(445 1,020)
(464 668)
(438 627)
955
561
915
811
1,000
1,240
730
749
1,210
913
910
(723 1,330)
(489 793)
(834 1,250)
(629 1,140)
(853 1,610)
(740 2,140)
(439 1,120)
(563 1,220)
(779 1,970)
(661 1,470)
(796 1,210)
1,287
1,343
2,108
2,496
2,626
692
1,422
1,137
901
970
5,122
Geometric mean and selected percentiles of urine concentrations (in g/g creatinine) for the total U.S. population aged 6 years and older, National
Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
Mexican Americans
60
20
40
Females
Males
Urinary genistein
(g/g creatinine)
80
Overall
611
1219
2039
4059
60+
611
NonHispanic Blacks
1219
2039
4059
60+
60
40
20
0
Urinary genistein
(g/g creatinine)
80
NonHispanic Whites
611
1219
2039
4059
60+
611
1219
4059
60+
Males
60
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary genistein
(g/g creatinine)
80
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
373
28.5
39.0
25.6
24.3
28.4
34.5
(26.9 30.2)
(33.7 45.1)
(23.0 28.5)
(21.8 27.1)
(25.2 32.1)
(31.4 38.0)
4.53
6.68
4.36
4.15
4.04
5.51
(4.29 4.79)
(5.55 8.43)
(3.90 4.67)
(3.81 4.55)
(3.52 4.65)
(4.85 6.21)
23.8
34.5
20.4
20.7
23.6
28.6
(21.6 26.1)
(27.4 38.3)
(17.8 24.8)
(17.8 23.6)
(19.1 27.8)
(24.5 32.6)
236
271
189
184
270
287
(210 270)
(216 388)
(151 236)
(144 236)
(207 415)
(226 398)
5,122
692
1,422
1,137
901
970
26.1
35.0
25.2
23.3
25.4
29.4
(24.0 28.3)
(28.8 42.4)
(21.1 30.0)
(20.8 26.1)
(21.6 29.8)
(24.8 34.7)
4.29
6.30
4.38
3.96
3.68
5.20
(4.03 4.56)
(5.10 7.99)
(3.66 4.66)
(3.39 4.38)
(3.27 4.51)
(4.11 6.32)
22.1
29.8
20.3
20.0
20.2
25.0
(19.5 24.9)
(21.2 38.2)
(17.0 29.0)
(16.0 24.4)
(16.8 25.5)
(20.0 30.4)
205
272
154
204
228
200
(179 237)
(158 503)
(128 256)
(149 244)
(155 386)
(151 259)
2,496
340
728
499
451
478
31.1
43.8
26.1
25.3
31.7
39.2
(28.3 34.1)
(33.4 57.4)
(22.5 30.3)
(20.9 30.7)
(26.2 38.3)
(33.9 45.4)
4.80
8.16
4.35
4.50
4.34
5.70
(4.35 5.45)
(4.38 10.4)
(3.72 5.23)
(3.83 5.53)
(2.99 5.61)
(4.76 6.64)
25.8
37.7
20.6
21.0
26.6
31.6
(22.9 28.1)
(26.4 50.0)
(16.5 24.8)
(17.6 26.9)
(21.3 32.6)
(25.8 39.0)
274
270
208
170
340
361
(230 320)
(212 798)
(164 269)
(124 289)
(210 631)
(289 530)
2,626
352
694
638
450
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
26.4
40.7
27.5
21.6
26.7
32.0
(24.2 28.8)
(31.0 53.5)
(23.7 32.0)
(18.6 25.2)
(20.1 35.4)
(23.9 42.9)
4.25
7.48
5.58
3.65
3.71
5.10
(3.81 4.70)
(5.51 9.00)
(4.31 6.56)
(2.96 4.28)
(2.37 4.69)
(2.91 6.94)
22.4
31.6
22.4
16.2
25.4
31.2
(19.5 24.6)
(22.8 44.7)
(18.9 26.4)
(13.1 20.9)
(16.8 33.8)
(22.8 40.4)
212
304
208
204
229
233
(186 275)
(161 1,100)
(139 366)
(138 255)
(131 629)
(141 535)
1,287
231
445
282
157
172
24.4
36.6
26.8
21.1
23.0
26.7
(20.6 28.9)
(25.7 52.1)
(21.9 32.8)
(15.6 28.5)
(14.4 36.9)
(16.1 44.4)
4.10
7.40
5.68
3.54
3.31
4.18
(3.50 4.54)
(5.50 9.04)
(4.54 6.56)
(2.60 4.32)
(1.22 4.36)
(1.75 7.13)
22.2
30.2
23.0
17.2
20.9
29.0
(17.2 26.4)
(19.7 43.0)
(16.8 30.7)
(12.4 23.3)
(8.19 31.2)
(10.9 49.6)
203
251
151
199
192
159
(136 275)
(129 659)
(116 347)
(112 328)
(92.0 2,070)
(59.4 4,830)
625
112
228
117
85
83
28.7
45.6
28.2
22.3
31.3
37.0
(25.0 32.9)
(31.5 66.2)
(23.4 34.1)
(15.8 31.3)
(24.2 40.4)
(22.8 60.0)
4.59
7.46
5.47
3.60
4.10
5.54
(3.67 5.88)
(4.51 9.99)
(2.84 7.19)
(2.14 6.28)
(.565 6.37)
(< LOD 8.83)
22.9
37.3
21.7
15.8
32.5
31.6
(18.5 27.1)
(20.3 68.7)
(17.8 28.9)
(12.0 23.4)
(18.1 44.1)
(13.4 82.7)
262
311
269
199
296
261
(189 391)
(166 1,460)
(155 425)
(116 728)
(151 594)
(142 745)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
374
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
22.3
36.1
24.5
17.9
23.4
20.4
(19.6 25.5)
(28.1 46.3)
(21.6 27.9)
(14.7 21.9)
(18.7 29.3)
(16.4 25.5)
3.95
6.36
4.32
3.49
3.30
4.39
(3.34 4.63)
(4.62 7.24)
(3.87 5.01)
(2.75 4.31)
(2.54 4.71)
(3.33 4.93)
19.1
25.2
22.0
14.0
21.4
17.5
(15.7 22.2)
(22.0 37.0)
(16.7 25.6)
(11.3 19.5)
(17.4 26.3)
(11.4 22.8)
159
325
150
123
173
130
(137 211)
(198 811)
(125 214)
(82.7 209)
(128 458)
(84.1 218)
1,343
207
496
249
231
160
20.7
36.4
23.8
17.0
18.9
19.6
(17.9 23.8)
(25.8 51.2)
(19.6 28.8)
(13.0 22.1)
(13.8 26.0)
(14.6 26.3)
3.40
4.60
3.95
3.20
2.97
3.86
(2.80 4.38)
(3.12 7.24)
(3.32 4.73)
(2.32 3.87)
(1.59 4.57)
(2.60 5.06)
17.6
24.9
21.2
12.6
17.4
18.3
(13.9 21.4)
(19.2 47.2)
(14.5 25.8)
(9.92 20.3)
(9.55 25.7)
(11.1 25.0)
173
396
159
150
140
112
(137 213)
(214 869)
(122 246)
(86.4 209)
(86.9 359)
(65.3 220)
661
99
258
116
114
74
23.8
35.8
25.3
18.8
27.9
21.0
(19.8 28.6)
(24.8 51.6)
(21.7 29.4)
(14.2 24.8)
(18.7 41.8)
(14.5 30.3)
4.65
6.98
4.87
3.79
3.62
4.51
(3.49 5.61)
(5.89 8.65)
(3.83 5.77)
(2.53 5.95)
(2.57 5.58)
(2.75 6.49)
20.4
25.0
22.7
14.3
24.7
16.5
(16.4 25.3)
(20.5 37.1)
(15.5 28.5)
(10.5 21.9)
(17.9 34.9)
(9.90 29.0)
156
261
143
119
221
134
(123 244)
(113 1,290)
(105 292)
(77.3 252)
(114 570)
(83.9 254)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
29.3
37.8
25.8
24.8
29.0
36.0
(27.3 31.4)
(31.2 45.8)
(22.3 29.7)
(21.4 28.9)
(25.3 33.2)
(32.8 39.6)
4.55
6.34
4.33
4.16
4.00
5.83
(4.17 4.93)
(5.11 8.41)
(3.67 4.93)
(3.52 4.76)
(3.18 4.90)
(4.85 6.54)
24.9
34.8
19.5
21.7
23.6
30.0
(22.1 27.7)
(24.5 43.0)
(16.7 26.0)
(18.1 28.3)
(17.7 30.3)
(26.4 34.1)
241
255
181
181
273
292
(209 291)
(175 577)
(143 247)
(134 289)
(202 477)
(224 431)
2,108
193
378
494
448
595
26.6
33.0
24.9
23.3
27.1
29.4
(23.9 29.5)
(23.9 45.6)
(19.3 32.3)
(19.3 28.2)
(22.5 32.5)
(24.5 35.4)
4.40
5.93
4.34
3.96
3.85
5.47
(3.87 4.86)
(4.89 8.18)
(3.13 5.24)
(2.52 4.69)
(3.22 4.95)
(3.88 6.92)
22.7
24.8
18.9
20.7
21.3
26.2
(19.4 26.2)
(17.3 40.0)
(14.5 31.4)
(15.9 28.7)
(16.4 27.9)
(20.0 33.5)
204
195
144
189
244
190
(169 261)
(126 945)
(121 311)
(105 339)
(155 623)
(147 263)
1,035
99
191
217
229
299
32.3
44.4
26.7
26.5
31.1
42.2
(29.0 35.9)
(31.3 62.8)
(21.7 32.8)
(20.8 33.7)
(25.1 38.6)
(36.1 49.3)
4.69
8.19
4.15
4.51
3.92
6.05
(4.14 5.40)
(2.79 11.4)
(3.63 5.22)
(3.50 5.62)
(2.63 5.82)
(4.82 7.49)
27.4
43.0
20.5
22.3
25.6
33.7
(23.5 32.6)
(26.0 58.2)
(15.8 26.1)
(18.1 33.0)
(17.7 34.1)
(27.6 42.2)
289
266
203
172
317
404
(227 361)
(164 1,300)
(156 342)
(126 300)
(180 675)
(291 567)
1,073
94
187
277
219
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
375
22.3
30.9
29.1
28.0
(17.7 28.1)
(28.5 33.6)
(27.3 31.0)
(25.3 31.0)
<LOD
3.52
3.39
2.98
(3.07 3.80)
(2.80 3.69)
(2.42 3.44)
23.8
25.8
24.5
23.2
(18.9 28.7)
(23.5 29.2)
(21.4 27.4)
(20.4 26.4)
380
426
507
576
(341 523)
(375 491)
(399 619)
(423 759)
28.3
44.5
35.8
42.5
(21.1 37.9)
(37.0 53.5)
(29.7 43.0)
(33.1 54.6)
29.4
26.3
25.9
25.3
2,557
2,794
2,594
2,528
1.84
6.82
5.15
4.86
(<LOD 3.04)
(4.89 8.11)
(3.19 6.46)
(< LOD 6.37)
27.8
37.7
34.7
34.0
(15.8 41.1)
(30.0 48.3)
(25.3 43.1)
(24.2 40.9)
489
489
293
985
(282 794)
(276 934)
(175 1,130)
(580 1,850)
331
396
341
351
(22.3 38.8)
(21.3 32.5)
(21.8 30.9)
(22.1 29.0)
2.12
3.43
3.45
3.32
(.684 3.24)
(2.34 4.13)
(2.56 4.00)
(2.25 3.67)
31.9
21.0
21.8
19.5
(24.3 41.6)
(18.1 26.5)
(17.0 28.6)
(16.3 23.8)
331
321
366
367
(199 1,360)
(294 487)
(322 464)
(238 617)
754
744
729
693
22.7
27.8
24.5
24.1
(17.3 29.9)
(23.8 32.4)
(21.9 27.4)
(19.8 29.3)
<LOD
3.29
2.97
2.55
(2.22 3.92)
(2.55 3.69)
(1.85 3.76)
22.8
22.9
19.7
21.3
(17.0 27.2)
(18.7 29.8)
(17.3 23.4)
(16.5 27.5)
417
379
320
447
(355 738)
(329 476)
(271 557)
(288 734)
536
604
554
583
15.7
32.7
31.1
26.1
(10.3 24.1)
(27.8 38.6)
(26.4 36.6)
(21.5 31.7)
<LOD
3.54
3.18
2.46
(2.26 4.12)
(1.96 3.75)
(1.82 2.97)
16.3
28.7
24.9
21.5
(12.5 26.8)
(24.2 32.1)
(19.7 29.8)
(16.8 29.2)
374
461
676
578
(246 894)
(377 1,260)
(496 1,670)
(326 1,220)
420
531
452
449
26.1
31.6
33.9
35.2
(21.7 31.3)
(25.8 38.8)
(29.7 38.7)
(30.3 40.8)
<LOD
3.00
3.39
4.13
(2.36 3.76)
(2.78 4.33)
(3.34 5.27)
27.3
25.5
29.5
27.9
(20.4 35.9)
(20.7 33.3)
(23.8 34.6)
(23.0 35.0)
371
491
539
589
(252 691)
(323 1,310)
(444 754)
(402 776)
516
519
518
452
23.3
26.2
26.4
25.8
(16.8 32.3)
(23.1 29.8)
(22.8 30.5)
(23.4 28.4)
<LOD
3.62
3.40
2.68
(2.52 4.01)
(2.66 3.63)
(1.98 3.40)
23.8
22.0
21.5
22.7
(17.7 31.9)
(19.4 26.2)
(17.6 26.3)
(19.3 26.2)
510
341
414
430
(329 893)
(282 427)
(346 574)
(319 629)
1,222
1,375
1,244
1,252
21.3
36.2
31.9
30.3
(17.5 26.0)
(32.8 39.9)
(28.7 35.5)
(25.8 35.5)
<LOD
3.50
3.29
3.07
(3.02 3.85)
(2.60 4.33)
(2.34 3.76)
23.1
29.5
27.1
23.5
(17.5 29.2)
(25.4 34.1)
(23.6 31.6)
(20.1 29.4)
357
540
545
658
(309 432)
(430 756)
(410 775)
(446 912)
1,335
1,419
1,350
1,276
28.4
26.6
28.0
24.9
(23.3 34.7)
(21.6 32.9)
(24.8 31.8)
(22.1 28.0)
1.40
3.75
3.35
2.66
(<LOD 2.74)
(2.96 4.09)
(2.29 3.99)
(1.46 3.47)
27.9
20.9
23.4
21.7
(22.5 35.0)
(16.1 28.7)
(18.8 28.1)
(18.1 23.7)
557
371
594
334
(322 1,290)
(280 484)
(426 884)
(277 520)
819
679
653
634
17.0
26.4
23.0
21.7
(12.2 23.6)
(19.2 36.4)
(18.1 29.1)
(18.8 25.1)
<LOD
2.91
3.11
2.58
(2.56 3.44)
(2.73 3.33)
(1.59 3.17)
19.4
22.7
20.4
18.5
(15.7 26.1)
(16.4 33.4)
(14.3 27.3)
(14.9 21.5)
284
369
304
350
(229 449)
(237 788)
(210 547)
(247 548)
597
692
681
662
23.3
30.5
30.5
28.2
(18.5 29.3)
(28.1 33.0)
(28.1 33.1)
(25.1 31.8)
<LOD
3.54
3.37
2.98
(2.96 3.81)
(2.66 3.83)
(2.18 3.59)
25.6
25.2
26.3
23.5
(19.4 31.7)
(23.3 28.7)
(21.7 31.4)
(20.0 29.0)
380
424
544
615
(346 574)
(376 494)
(362 747)
(427 810)
901
1,211
1,069
1,039
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
376
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2000
95th Percentile
1500
1000
500
H
H
H
H
H
H
H
H
H
0
50
50th Percentile
40
H
H
H
H
30
H
H
H
H
H
H
H
20
H
H
H
H
H
H
10
10
6
H
H
H
H
H
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
377
378
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
59.0
78.4
63.9
73.8
60.4
89.4
91.6
61.6
60.9
60.9
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
66.6
(54.1 64.4)
(67.6 90.9)
(58.7 69.6)
(67.2 81.1)
(55.3 66.0)
(77.7 103)
(80.5 104)
(53.3 71.3)
(54.9 67.6)
(52.7 70.5)
(62.1 71.5)
3.07
4.48
3.03
3.63
3.04
7.38
5.85
3.32
3.04
2.24
3.31
(2.14 3.68)
(3.48 5.77)
(2.26 3.41)
(2.74 4.56)
(2.39 3.41)
(5.07 8.35)
(3.92 6.63)
(1.80 3.99)
(1.89 3.48)
(1.47 3.58)
(2.74 3.72)
4.71
7.05
4.66
6.35
4.47
10.2
9.07
4.82
4.56
4.31
5.35
(3.62 5.66)
(5.74 7.82)
(3.69 6.11)
(4.53 7.62)
(3.72 5.61)
(7.62 13.1)
(6.69 9.60)
(3.43 6.14)
(3.42 5.90)
(2.73 6.34)
(4.25 6.22)
48.6
72.3
58.5
66.0
55.5
68.4
77.3
54.3
56.5
60.5
60.4
(44.8 56.8)
(61.3 85.2)
(52.0 65.3)
(58.0 73.7)
(49.5 61.5)
(59.2 86.6)
(65.0 94.5)
(47.2 65.9)
(47.0 65.5)
(48.9 73.4)
(54.7 65.9)
1,350
1,180
1,040
1,200
1,000
1,180
1,310
1,210
1,120
839
1,170
(1,130 1,500)
(886 1,610)
(930 1,250)
(1,060 1,350)
(836 1,270)
(996 1,870)
(989 1,760)
(835 1,560)
(893 1,340)
(709 1,310)
(1,000 1,290)
1,800
2,220
1,600
1,750
1,910
2,250
2,180
1,860
1,510
1,600
1,850
(1,560 2,450)
(1,500 3,390)
(1,420 2,150)
(1,520 2,220)
(1,490 2,630)
(1,550 6,320)
(1,710 3,350)
(1,490 2,430)
(1,270 3,510)
(1,210 2,660)
(1,590 2,200)
1,287
1,343
2,108
2,496
2,626
692
1,422
1,137
901
970
5,122
Geometric mean and selected percentiles of urine concentrations (in g/L) for the total U.S. population aged 6 years and older, National Health and
Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
Mexican Americans
150
50
100
Females
Males
Urinary daidzein
(g/L)
200
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
150
100
50
0
Urinary daidzein
(g/L)
200
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
150
50
100
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary daidzein
(g/L)
200
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
379
66.6
89.4
91.6
61.6
60.9
60.9
(62.1 71.5)
(77.7 103)
(80.5 104)
(53.3 71.3)
(54.9 67.6)
(52.7 70.5)
8.65
15.7
14.5
8.20
7.71
7.92
(7.74 9.48)
(12.2 18.1)
(11.8 15.8)
(6.00 10.4)
(6.35 8.67)
(6.54 9.19)
60.4
68.4
77.3
54.3
56.5
60.5
(54.7 65.9)
(59.2 86.6)
(65.0 94.5)
(47.2 65.9)
(47.0 65.5)
(48.9 73.4)
613
653
834
571
572
471
(525 684)
(619 916)
(659 969)
(422 752)
(410 807)
(399 618)
5,122
692
1,422
1,137
901
970
73.8
87.3
103
70.4
68.4
64.4
(67.2 81.1)
(72.9 105)
(85.2 124)
(58.8 84.2)
(57.9 80.8)
(52.0 79.9)
9.92
17.5
17.3
9.80
8.55
9.16
(8.68 11.9)
(12.2 21.0)
(13.9 19.4)
(5.43 12.8)
(7.15 9.37)
(7.75 11.8)
66.0
64.0
86.6
65.3
66.2
57.7
(58.0 73.7)
(51.5 91.4)
(64.8 107)
(51.7 75.0)
(47.7 84.7)
(43.8 78.5)
695
874
863
729
671
561
(589 786)
(497 1,150)
(526 1,320)
(544 968)
(409 930)
(417 749)
2,496
340
728
499
451
478
60.4
91.6
81.0
54.0
54.6
58.3
(55.3 66.0)
(72.4 116)
(69.6 94.3)
(44.1 66.2)
(47.9 62.3)
(48.5 70.2)
7.79
14.3
11.1
7.31
6.98
7.04
(6.41 8.76)
(9.67 17.9)
(9.30 14.5)
(5.72 9.03)
(4.64 8.60)
(4.21 8.11)
55.5
78.1
71.1
47.9
48.2
60.9
(49.5 61.5)
(57.3 99.4)
(59.6 93.6)
(38.1 63.9)
(40.6 58.2)
(46.8 80.2)
507
643
812
383
511
403
(431 619)
(455 882)
(604 936)
(309 585)
(395 736)
(362 562)
2,626
352
694
638
450
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
59.0
78.3
87.3
50.5
55.4
42.1
(54.1 64.4)
(61.0 100)
(72.5 105)
(42.9 59.3)
(43.6 70.3)
(31.0 57.3)
7.94
16.6
12.3
6.19
7.50
5.61
(6.47 8.95)
(11.6 18.1)
(8.90 16.5)
(4.34 8.14)
(4.68 10.4)
(2.89 7.89)
48.6
64.5
74.6
35.3
48.2
40.7
(44.8 56.8)
(51.3 83.2)
(62.2 96.1)
(28.1 47.1)
(38.0 62.6)
(22.8 61.7)
671
588
812
821
475
366
(496 848)
(321 2,270)
(558 1,000)
(468 1,160)
(347 1,260)
(222 1,200)
1,287
231
445
282
157
172
60.8
76.3
90.0
52.0
60.4
41.1
(52.2 70.9)
(57.3 102)
(69.7 116)
(37.9 71.3)
(39.7 92.0)
(23.7 71.4)
8.82
17.3
16.0
7.67
8.25
7.55
(7.42 9.78)
(7.01 20.6)
(9.79 17.8)
(3.36 10.2)
(4.94 10.0)
(1.89 9.13)
48.2
60.0
84.7
36.0
47.8
40.0
(40.1 56.8)
(41.0 109)
(53.8 129)
(27.9 48.7)
(21.4 81.5)
(15.3 84.1)
742
481
590
846
790
329
(484 1,050)
(312 1,370)
(408 1,270)
(468 1,330)
(356 4,980)
(154 2,020)
625
112
228
117
85
83
57.1
80.5
84.6
48.7
50.4
42.9
(48.9 66.7)
(53.3 121)
(67.0 107)
(32.2 73.6)
(35.6 71.2)
(25.7 71.5)
6.73
14.4
10.4
5.71
5.24
5.28
(5.24 8.15)
(5.79 22.1)
(8.24 13.6)
(3.33 8.01)
(3.72 11.2)
(1.79 7.45)
49.8
65.4
71.1
32.3
48.4
40.1
(42.3 64.2)
(49.0 98.4)
(56.2 97.1)
(23.7 67.2)
(35.4 84.6)
(18.6 73.7)
556
735
867
594
346
381
(418 871)
(283 3,410)
(623 1,380)
(295 1,790)
(267 484)
(226 2,270)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
380
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
78.4
102
120
68.4
77.2
53.5
(67.6 90.9)
(80.6 129)
(104 139)
(53.2 88.0)
(59.6 99.9)
(37.7 75.8)
9.87
11.5
17.5
11.3
8.40
7.55
(8.52 11.6)
(8.37 16.0)
(13.5 20.8)
(8.37 13.1)
(6.24 11.2)
(4.20 9.29)
72.3
95.8
111
50.7
75.0
46.9
(61.3 85.2)
(70.0 129)
(92.3 144)
(41.3 76.5)
(58.8 111)
(28.8 78.8)
639
927
895
601
457
361
(474 766)
(487 2,170)
(756 1,160)
(408 893)
(377 839)
(259 823)
1,343
207
496
249
231
160
90.2
101
132
94.7
78.7
53.1
(75.1 108)
(70.3 145)
(107 164)
(64.5 139)
(54.4 114)
(37.3 75.7)
12.1
11.2
19.4
13.2
8.53
8.34
(8.49 14.2)
(4.75 15.9)
(11.4 24.1)
(7.79 16.6)
(6.17 13.3)
(7.92 12.2)
83.6
103
120
67.3
83.2
40.3
(64.7 110)
(42.5 215)
(95.6 152)
(41.4 151)
(58.0 134)
(27.8 70.4)
724
1,050
1,140
851
390
325
(584 1,050)
(534 2,140)
(766 1,980)
(564 1,400)
(368 701)
(169 1,800)
661
99
258
116
114
74
69.7
103
109
52.7
75.9
53.7
(57.7 84.2)
(74.2 142)
(91.8 129)
(37.2 74.6)
(51.0 113)
(31.4 91.7)
9.41
11.0
14.3
9.40
7.94
6.06
(7.40 11.2)
(7.50 24.0)
(9.60 22.6)
(5.61 12.1)
(4.01 11.8)
(2.92 9.07)
64.7
85.1
104
43.3
69.9
55.3
(54.2 77.9)
(58.3 129)
(73.9 142)
(26.0 75.9)
(47.9 109)
(22.5 106)
476
687
757
408
462
368
(427 675)
(398 7,580)
(652 1,140)
(280 622)
(369 2,070)
(257 1,170)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
63.9
86.5
91.5
58.5
57.9
61.6
(58.7 69.6)
(70.6 106)
(77.3 108)
(47.8 71.7)
(50.4 66.5)
(52.9 71.8)
8.36
16.0
15.2
6.75
7.22
8.03
(6.60 9.38)
(11.4 20.6)
(10.6 17.3)
(4.48 10.3)
(5.29 8.66)
(6.59 9.36)
58.5
66.6
76.3
53.0
50.6
61.2
(52.0 65.3)
(56.0 93.6)
(59.5 100)
(44.8 66.9)
(41.9 65.3)
(49.1 78.5)
571
643
824
484
575
469
(479 684)
(450 985)
(606 977)
(343 753)
(407 893)
(396 662)
2,108
193
378
494
448
595
70.2
83.9
102
63.4
66.9
64.3
(62.0 79.4)
(62.4 113)
(78.3 134)
(48.0 83.7)
(54.2 82.7)
(50.0 82.9)
9.34
18.4
16.6
8.03
8.29
9.18
(7.77 12.2)
(7.93 21.7)
(12.7 23.1)
(3.27 14.2)
(6.53 9.37)
(6.88 12.0)
63.8
63.1
80.1
59.0
63.4
58.7
(54.1 72.9)
(49.4 94.1)
(55.1 118)
(43.8 77.0)
(42.1 83.3)
(42.2 88.7)
680
651
812
575
670
591
(509 779)
(271 1,180)
(466 1,440)
(341 1,010)
(409 970)
(416 762)
1,035
99
191
217
229
299
58.3
89.7
81.0
54.0
50.0
59.6
(52.6 64.7)
(67.1 120)
(66.4 98.8)
(42.7 68.5)
(42.1 59.4)
(49.4 71.8)
7.50
14.9
11.8
6.43
5.98
7.25
(5.79 8.68)
(5.43 19.0)
(7.34 15.8)
(5.19 8.74)
(3.46 8.36)
(3.83 8.51)
53.1
89.1
73.3
51.1
43.5
61.4
(47.0 61.0)
(50.9 141)
(52.3 101)
(38.2 64.5)
(32.6 53.4)
(49.3 83.1)
484
583
817
382
514
401
(397 608)
(352 7,440)
(455 970)
(293 683)
(309 843)
(357 656)
1,073
94
187
277
219
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
381
75.1
51.7
66.7
66.5
(61.9 91.1)
(46.6 57.5)
(60.4 73.7)
(59.7 74.1)
6.56
< LOD
5.71
4.98
90.5
84.9
84.9
94.1
(75.1 109)
(71.6 101)
(71.6 101)
(74.3 119)
123
69.3
89.0
94.4
(3.36 8.12)
(4.00 6.43)
(3.70 6.58)
69.8
52.3
62.0
58.8
(58.1 82.4)
(49.0 57.5)
(54.1 69.7)
(51.4 67.7)
1,310
1,240
1,070
1,180
(1,030 1,550)
(919 1,850)
(924 1,330)
(1,010 1,380)
2,553
2,794
2,594
2,528
8.59
11.3
13.2
7.73
(1.43 13.6)
(3.15 12.4)
(9.77 16.2)
(6.35 10.8)
100
72.1
65.6
73.8
(71.0 129)
(56.6 96.9)
(56.7 92.7)
(56.1 95.1)
1,110
1,050
788
1,870
(707 1,740)
(684 1,650)
(644 1,070)
(1,130 6,350)
330
396
341
351
(91.4 166)
(52.6 91.3)
(75.2 105)
(76.0 117)
14.7
2.63
9.05
9.14
(7.23 17.6)
(< LOD 6.02)
(6.06 9.91)
(6.14 11.0)
124
69.8
77.9
76.9
(85.6 165)
(53.2 87.5)
(60.1 104)
(59.6 102)
1,460
1,330
1,190
1,370
(1,100 3,300)
(977 2,110)
(927 1,970)
(981 2,270)
753
744
729
693
80.6
51.5
59.9
63.4
(64.3 101)
(42.7 62.1)
(47.6 75.3)
(51.7 77.6)
7.55
< LOD
4.82
4.81
(3.34 9.89)
67.1
50.7
56.1
52.3
(55.6 82.5)
(40.4 64.9)
(44.9 69.0)
(44.7 68.5)
1,730
1,200
1,170
1,360
(983 4,150)
(763 1,930)
(809 1,480)
(737 2,240)
534
604
554
583
55.4
50.6
67.9
54.9
(39.0 78.6)
(40.4 63.3)
(58.3 79.2)
(47.3 63.7)
2.50
< LOD
5.13
3.79
56.7
53.1
62.2
50.5
(40.8 70.7)
(39.3 68.2)
(46.1 78.7)
(41.4 61.9)
1,060
1,760
1,290
983
(801 1,520)
(859 3,030)
(840 3,440)
(665 1,300)
420
531
452
449
64.6
32.0
55.7
66.4
(53.0 78.8)
(26.2 39.0)
(44.4 69.9)
(54.6 80.8)
6.47
< LOD
4.07
4.76
61.5
33.8
56.5
62.5
(45.9 85.0)
(28.4 40.4)
(43.8 76.3)
(43.9 89.5)
665
636
780
952
(556 991)
(397 1,990)
(585 1,660)
(707 1,600)
516
519
518
452
88.9
49.8
73.8
73.9
(71.4 111)
(42.8 57.9)
(63.4 85.9)
(65.3 83.6)
7.75
< LOD
6.35
6.32
80.5
50.7
65.2
66.2
(66.9 112)
(46.9 55.6)
(56.4 76.4)
(53.9 78.3)
1,540
918
1,200
1,180
(1,020 2,240)
(727 1,400)
(1,020 1,370)
(1,000 1,430)
1,220
1,375
1,244
1,252
64.1
53.6
60.7
60.1
(52.9 77.6)
(48.1 59.8)
(53.6 68.8)
(52.5 68.9)
5.62
< LOD
4.61
4.40
57.6
55.4
57.4
52.4
(45.2 73.2)
(49.8 62.4)
(49.3 67.3)
(45.0 61.4)
1,210
1,440
884
1,140
(652 2,010)
(1,190 1,990)
(670 1,390)
(843 1,480)
1,333
1,419
1,350
1,276
78.9
39.2
57.4
60.6
(59.8 104)
(28.5 54.0)
(50.2 65.7)
(53.3 68.9)
6.78
< LOD
4.90
4.35
66.1
39.8
45.4
54.0
(48.8 90.2)
(28.8 59.7)
(35.3 53.3)
(44.1 64.5)
1,340
880
1,380
1,320
(977 3,000)
(633 1,770)
(954 1,720)
(981 1,550)
816
679
653
634
91.5
66.3
75.5
81.3
(71.1 118)
(47.7 91.9)
(56.5 101)
(71.6 92.4)
7.48
< LOD
7.09
6.97
102
72.9
67.6
76.5
(84.0 131)
(52.5 96.5)
(51.5 89.3)
(69.9 94.7)
1,030
1,410
1,150
1,200
(771 1,640)
(950 2,850)
(699 2,380)
(878 1,960)
596
692
681
662
74.7
48.6
65.9
62.0
(61.8 90.3)
(43.8 53.9)
(58.7 74.0)
(54.4 70.7)
7.25
< LOD
5.10
4.55
66.8
49.8
62.3
54.1
(57.0 77.4)
(45.8 53.1)
(53.0 71.3)
(46.9 63.9)
1,360
1,140
1,050
1,030
(990 1,730)
(811 1,910)
(843 1,360)
(884 1,310)
901
1,211
1,069
1,039
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
(3.21 6.58)
(2.19 6.27)
4059 years
19992000
20012002
20032004
20052006
(5.61 9.10)
(2.51 5.72)
(1.85 8.24)
Gender
Males
19992000
20012002
20032004
20052006
(5.85 10.4)
(3.20 8.53)
(4.02 7.91)
Females
19992000
20012002
20032004
20052006
(1.86 7.80)
(3.50 5.95)
(2.99 5.94)
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
(4.37 8.83)
(3.74 5.99)
(2.74 5.80)
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
(3.27 8.95)
(3.33 6.39)
(3.17 6.33)
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
382
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
8000
95th Percentile
6000
4000
2000
H
H
H
H
H
H
H
H
H
H
0
200
50th Percentile
150
H
100
H
H
50
H
H
H
H
H
H
H
H
H
H
H
H
H
H
0
20
H
H
H
10
H
H
H
H
H
H
H
H
H
H
H
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
15
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
383
384
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
53.2
55.0
65.1
58.6
68.9
96.8
68.3
52.5
61.6
71.4
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
63.7
(47.7 59.3)
(48.8 62.1)
(60.7 69.7)
(53.5 64.1)
(63.4 74.9)
(85.1 110)
(60.0 77.7)
(46.6 59.3)
(56.1 67.8)
(63.3 80.5)
(60.0 67.5)
3.88
3.99
4.86
4.34
5.13
9.11
5.75
3.98
4.02
5.84
4.69
(2.31 4.18)
(3.43 4.57)
(4.30 5.83)
(3.58 4.79)
(4.29 5.94)
(7.67 11.1)
(4.91 6.71)
(2.80 4.53)
(2.73 4.80)
(4.78 7.05)
(4.17 5.11)
4.66
5.90
7.25
6.32
7.44
12.3
7.91
5.88
5.99
8.24
6.83
(4.10 5.41)
(4.51 6.56)
(6.49 7.90)
(5.09 7.08)
(6.45 8.14)
(9.30 15.7)
(6.76 9.36)
(4.34 6.73)
(4.72 7.17)
(7.26 9.16)
(6.29 7.32)
47.7
48.0
56.0
49.9
60.0
72.6
56.2
44.6
51.7
63.9
54.6
(38.6 56.1)
(39.1 59.6)
(50.6 60.8)
(45.5 55.2)
(51.0 68.9)
(63.3 87.8)
(47.3 69.0)
(37.9 52.2)
(46.0 58.2)
(51.3 78.0)
(50.2 58.5)
973
825
1,080
924
1,130
1,630
910
878
1,140
1,010
1,060
(859 1,170)
(645 1,040)
(940 1,200)
(812 1,100)
(1,010 1,510)
(1,000 2,990)
(755 1,210)
(685 1,100)
(895 2,180)
(828 1,180)
(939 1,150)
1,750
1,360
1,890
1,550
2,100
3,010
1,330
1,360
2,760
1,770
1,890
(1,360 2,390)
(1,020 2,320)
(1,480 3,030)
(1,190 2,640)
(1,630 3,290)
(1,860 5,360)
(1,180 2,730)
(1,090 2,480)
(1,510 4,990)
(1,120 2,940)
(1,520 2,820)
1,287
1,343
2,108
2,496
2,626
692
1,422
1,137
901
970
5,122
Geometric mean and selected percentiles of urine concentrations (in g/g creatinine) for the total U.S. population aged 6 years and older, National
Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
Mexican Americans
150
50
100
Females
Males
Urinary daidzein
(g/g creatinine)
200
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
150
100
50
0
Urinary daidzein
(g/g creatinine)
200
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
150
50
100
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary daidzein
(g/g creatinine)
200
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
385
63.7
96.8
68.3
52.5
61.6
71.4
(60.0 67.5)
(85.1 110)
(60.0 77.7)
(46.6 59.3)
(56.1 67.8)
(63.3 80.5)
9.68
19.0
11.5
8.66
8.59
11.3
(8.96 10.5)
(14.8 23.0)
(9.80 12.7)
(7.41 9.62)
(7.78 9.25)
(10.1 12.0)
54.6
72.6
56.2
44.6
51.7
63.9
(50.2 58.5)
(63.3 87.8)
(47.3 69.0)
(37.9 52.2)
(46.0 58.2)
(51.3 78.0)
522
697
522
424
570
565
(463 593)
(580 924)
(419 738)
(338 501)
(410 894)
(462 702)
5,122
692
1,422
1,137
901
970
58.6
87.5
69.8
51.3
54.2
59.3
(53.5 64.1)
(73.6 104)
(57.3 85.0)
(44.0 59.9)
(46.0 63.9)
(49.0 71.9)
8.91
15.8
11.6
7.55
7.88
10.0
(8.16 9.82)
(11.8 21.6)
(9.54 13.5)
(6.03 9.50)
(6.08 8.73)
(8.24 11.5)
49.9
68.2
53.9
43.4
47.0
51.0
(45.5 55.2)
(54.2 82.8)
(43.2 69.7)
(36.9 50.3)
(38.7 60.1)
(43.3 65.7)
467
733
580
451
458
423
(421 543)
(435 1,190)
(404 842)
(379 595)
(305 766)
(370 565)
2,496
340
728
499
451
478
68.9
108
66.7
53.8
69.6
82.6
(63.4 74.9)
(86.1 135)
(58.4 76.1)
(44.6 64.9)
(60.7 79.8)
(70.8 96.4)
10.7
22.3
11.4
9.21
9.63
12.7
(9.41 12.2)
(14.6 27.7)
(9.31 13.0)
(7.51 10.7)
(7.84 12.3)
(10.2 14.5)
60.0
84.3
58.6
46.6
57.3
75.0
(51.0 68.9)
(68.0 112)
(45.9 76.2)
(34.7 63.9)
(48.8 68.7)
(58.7 92.5)
582
696
514
349
699
686
(493 702)
(561 1,060)
(379 662)
(237 654)
(459 1,130)
(537 965)
2,626
352
694
638
450
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
53.2
98.3
67.5
40.7
50.7
52.0
(47.7 59.3)
(76.7 126)
(56.8 80.1)
(33.7 49.2)
(39.5 65.0)
(36.8 73.4)
6.93
20.2
10.8
5.59
6.01
6.95
(6.05 7.61)
(16.6 23.2)
(7.46 13.3)
(4.19 7.06)
(4.56 7.76)
(5.30 8.24)
47.7
80.4
57.9
30.1
45.9
49.3
(38.6 56.1)
(62.1 108)
(49.4 71.5)
(24.2 42.4)
(30.2 62.8)
(31.5 75.6)
527
601
492
499
537
344
(431 601)
(332 1,940)
(380 834)
(290 809)
(275 990)
(253 971)
1,287
231
445
282
157
172
48.0
91.5
65.2
37.8
44.3
36.7
(40.5 56.9)
(66.0 127)
(50.4 84.4)
(27.7 51.5)
(29.3 67.1)
(21.9 61.5)
6.05
20.4
12.3
4.82
5.90
5.57
(5.04 7.07)
(15.5 23.2)
(7.04 13.8)
(2.22 6.78)
(3.67 7.61)
(4.50 6.89)
40.4
74.0
55.2
27.8
29.8
35.3
(30.2 56.1)
(50.3 130)
(37.2 91.2)
(20.6 44.4)
(16.1 73.2)
(15.0 66.2)
469
429
424
432
552
309
(355 594)
(313 1,510)
(302 861)
(264 899)
(258 1,640)
(110 2,740)
625
112
228
117
85
83
59.6
106
69.9
44.5
58.7
69.2
(50.8 69.9)
(74.4 151)
(57.9 84.3)
(29.8 66.4)
(42.8 80.4)
(41.2 116)
7.76
20.1
10.1
6.66
6.72
8.25
(6.39 9.44)
(13.5 27.3)
(6.44 13.3)
(4.07 8.39)
(4.24 11.8)
(3.99 13.0)
53.5
85.2
65.8
33.2
52.7
64.1
(43.2 62.6)
(68.2 112)
(43.1 81.9)
(18.7 56.2)
(40.8 75.2)
(24.7 157)
602
898
736
569
427
443
(406 897)
(305 3,630)
(477 881)
(207 2,670)
(256 924)
(255 2,030)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
386
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
55.0
95.6
69.0
42.4
56.1
47.7
(48.8 62.1)
(75.9 121)
(60.5 78.8)
(34.5 52.2)
(45.9 68.6)
(35.0 64.9)
8.72
13.3
9.54
6.72
8.30
9.05
(7.34 9.46)
(11.1 18.8)
(8.52 11.6)
(5.68 9.60)
(5.49 10.0)
(6.31 10.7)
48.0
81.9
66.5
28.1
48.7
42.0
(39.1 59.6)
(67.4 108)
(51.3 85.0)
(23.4 44.7)
(38.5 66.9)
(25.3 67.0)
437
1,010
496
368
422
295
(389 538)
(647 1,910)
(424 640)
(211 702)
(290 614)
(223 603)
1,343
207
496
249
231
160
52.7
95.5
70.8
45.4
45.0
39.0
(44.7 62.0)
(67.1 136)
(58.3 86.0)
(31.9 64.8)
(31.4 64.5)
(26.7 56.8)
7.20
11.2
9.79
6.49
6.01
7.23
(6.40 8.99)
(8.55 13.9)
(7.70 11.8)
(3.95 8.98)
(3.03 8.96)
(4.44 11.3)
44.4
94.6
70.0
27.2
42.1
25.7
(32.0 63.8)
(39.1 139)
(53.8 88.7)
(20.2 77.0)
(29.9 58.2)
(19.2 50.9)
440
1,210
584
410
338
238
(391 532)
(646 2,090)
(426 910)
(234 1,360)
(222 684)
(114 996)
661
99
258
116
114
74
57.1
95.7
67.3
40.1
67.3
54.2
(48.2 67.6)
(68.8 133)
(56.6 80.0)
(30.2 53.3)
(48.1 94.2)
(34.6 84.9)
9.36
18.3
9.35
7.29
9.31
9.07
(7.44 11.4)
(6.78 23.1)
(7.76 13.2)
(4.25 11.4)
(6.16 12.6)
(4.74 11.6)
49.4
77.5
62.7
29.9
55.0
55.5
(39.9 66.3)
(61.2 95.9)
(46.6 85.6)
(23.8 42.2)
(35.4 90.6)
(26.1 79.8)
419
758
458
310
552
312
(330 593)
(307 2,820)
(328 895)
(153 668)
(299 922)
(185 1,040)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
65.1
93.9
71.8
54.0
62.2
73.5
(60.7 69.7)
(77.9 113)
(60.1 85.8)
(45.5 64.1)
(55.5 69.8)
(65.4 82.6)
10.0
17.1
12.3
9.24
8.59
11.4
(8.80 11.4)
(11.9 25.8)
(10.4 13.6)
(7.14 10.8)
(7.54 10.0)
(10.1 12.6)
56.0
70.3
57.5
46.4
52.9
65.9
(50.6 60.8)
(57.7 96.8)
(46.0 74.4)
(37.6 57.0)
(43.2 60.5)
(55.2 80.0)
519
577
563
403
582
548
(451 658)
(423 991)
(415 763)
(315 578)
(397 1,030)
(459 714)
2,108
193
378
494
448
595
58.7
81.3
73.1
50.3
56.0
60.0
(52.2 65.9)
(60.7 109)
(55.1 97.1)
(39.2 64.7)
(46.0 68.2)
(48.0 74.9)
9.03
15.6
12.3
8.53
8.18
10.1
(8.12 10.5)
(10.8 22.6)
(8.32 16.7)
(4.63 10.7)
(5.53 8.99)
(8.07 11.6)
49.9
60.2
54.3
41.7
46.0
54.2
(43.4 57.4)
(45.1 95.9)
(40.6 82.5)
(33.8 54.3)
(37.2 62.3)
(40.5 79.6)
6456
540
653
425
465
402
(369 638)
(287 2,790)
(397 892)
(296 777)
(304 946)
(357 501)
1,035
99
191
217
229
299
71.9
111
70.4
57.9
69.2
86.3
(65.4 79.1)
(84.1 146)
(58.7 84.5)
(46.6 71.9)
(59.3 80.8)
(74.3 100)
11.6
23.8
12.2
10.1
9.16
13.4
(9.27 13.6)
(12.9 33.2)
(7.26 16.3)
(7.66 13.0)
(7.25 13.0)
(10.1 15.6)
63.3
94.0
66.9
47.8
57.6
78.0
(53.8 73.5)
(66.0 124)
(43.9 86.4)
(35.8 67.5)
(46.3 71.7)
(59.8 97.1)
589
578
520
385
894
656
(484 818)
(397 1,780)
(372 713)
(237 817)
(410 1,310)
(519 974)
1,073
94
187
277
219
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
387
68.5
48.5
62.5
64.8
(55.9 83.9)
(43.7 54.0)
(58.3 67.0)
(58.7 71.6)
6.25
<LOD
6.82
6.88
92.6
96.4
90.4
104
(76.3 112)
(79.0 118)
(77.2 106)
(83.1 130)
83.1
53.4
66.6
70.0
(2.72 8.90)
(5.96 7.48)
(6.01 7.54)
65.1
48.3
56.0
52.3
(52.8 80.8)
(43.2 56.3)
(49.9 63.5)
(47.9 59.7)
943
955
1,050
1,070
(838 1,150)
(805 1,220)
(858 1,150)
(924 1,380)
2,553
2,794
2,594
2,528
10.7
13.0
15.8
10.8
(8.22 13.1)
(6.07 14.7)
(8.36 20.2)
(8.23 13.3)
93.0
85.9
72.4
73.8
(72.1 114)
(60.7 126)
(58.2 99.0)
(59.5 93.5)
1,050
934
700
2,350
(835 2,070)
(712 1,370)
(563 1,660)
(1,430 4,630)
330
396
341
351
(58.4 118)
(40.8 70.0)
(55.7 79.6)
(56.9 86.2)
7.76
2.77
8.31
7.67
(3.13 11.0)
(<LOD 4.26)
(6.76 9.40)
(5.31 10.3)
84.8
50.8
56.3
54.7
(54.0 123)
(38.8 77.4)
(45.0 74.4)
(42.8 74.1)
991
1,030
873
914
(725 2,680)
(677 1,580)
(667 1,270)
(714 1,950)
753
744
729
693
63.9
41.6
50.5
54.6
(50.7 80.6)
(35.1 49.4)
(43.0 59.3)
(45.0 66.4)
5.10
<LOD
5.95
5.60
(2.37 8.40)
52.8
43.0
42.6
47.0
(41.0 81.7)
(30.4 54.2)
(36.1 50.6)
(34.2 65.2)
1,100
849
870
875
(811 1,740)
(615 1,040)
(570 1,360)
(645 1,200)
534
604
554
583
56.2
50.2
65.1
58.5
(39.7 79.6)
(40.3 62.7)
(56.5 75.2)
(50.8 67.4)
3.39
<LOD
5.51
6.35
50.3
53.3
58.2
46.1
(39.1 71.2)
(40.4 67.5)
(48.9 70.6)
(40.8 56.2)
827
1,220
1,220
1,090
(624 1,360)
(848 2,140)
(713 4,260)
(714 2,890)
420
531
452
449
77.6
37.9
65.9
77.1
(63.4 94.8)
(31.0 46.3)
(55.1 78.9)
(65.2 91.1)
8.64
<LOD
8.01
9.10
82.7
36.0
61.8
64.5
(61.7 104)
(25.9 44.2)
(48.0 78.2)
(49.7 87.6)
761
726
973
1,020
(575 996)
(502 1,780)
(653 1,870)
(827 1,610)
516
519
518
452
69.7
40.5
57.7
59.5
(54.7 88.8)
(34.8 47.1)
(49.4 67.3)
(53.3 66.3)
6.40
<LOD
6.10
6.42
69.8
41.6
48.9
50.7
(52.1 84.2)
(34.6 47.9)
(42.3 58.2)
(43.2 57.6)
1,040
773
918
926
(908 1,180)
(615 969)
(699 1,230)
(814 1,170)
1,220
1,375
1,244
1,252
67.4
57.6
67.4
70.4
(54.8 82.9)
(50.8 65.2)
(60.8 74.9)
(61.3 80.8)
5.93
<LOD
7.43
7.47
62.1
59.1
64.9
57.1
(51.2 80.8)
(48.2 72.9)
(54.7 73.3)
(45.2 71.2)
845
1,170
1,090
1,180
(622 1,420)
(949 1,430)
(820 1,490)
(1,020 1,860)
1,333
1,419
1,350
1,276
72.4
36.9
51.8
54.7
(59.1 88.9)
(27.8 49.0)
(45.0 59.6)
(45.6 65.7)
6.47
<LOD
4.37
4.79
64.0
37.0
47.7
47.2
(46.9 90.9)
(24.9 57.3)
(36.4 58.1)
(36.0 60.6)
1,380
718
1,120
917
(886 3,380)
(584 1,220)
(870 1,380)
(662 1,130)
816
679
653
634
58.7
46.2
53.2
57.0
(46.0 74.9)
(33.2 64.3)
(42.4 66.7)
(50.3 64.5)
3.74
<LOD
5.94
5.39
67.0
49.5
45.3
48.5
(52.1 86.0)
(35.7 69.9)
(30.0 72.1)
(42.1 59.5)
797
927
706
902
(598 945)
(620 1,820)
(564 1,030)
(643 1,350)
596
692
681
662
73.6
48.0
64.9
65.2
(60.7 89.2)
(43.5 53.0)
(59.9 70.4)
(57.9 73.3)
8.09
<LOD
7.20
7.34
67.9
47.0
58.2
52.6
(57.2 81.4)
(42.8 55.4)
(50.9 66.8)
(46.5 60.6)
917
954
1,090
1,070
(794 1,390)
(838 1,220)
(818 1,320)
(896 1,460)
901
1,211
1,069
1,039
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
(4.11 7.11)
(3.60 7.48)
4059 years
19992000
20012002
20032004
20052006
(<LOD 8.27)
(4.02 7.94)
(3.70 7.64)
(5.52 12.0)
(6.03 9.02)
(6.42 11.4)
Gender
Males
19992000
20012002
20032004
20052006
(1.93 9.19)
(4.73 7.35)
(4.79 7.34)
Females
19992000
20012002
20032004
20052006
(2.71 8.38)
(6.03 8.22)
(5.83 8.70)
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
(3.20 8.73)
(2.94 5.89)
(3.91 5.94)
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
(<LOD 6.58)
(3.99 6.84)
(4.33 6.69)
Non-Hispanic Whites
19992000
20012002
20032004
20052006
(3.07 10.9)
(6.28 8.08)
(5.54 8.21)
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
388
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
5000
95th Percentile
4000
3000
H
2000
1000
H
H
H
H
50th Percentile
150
100
H
H
H
H
H
H
50
H
H
H
H
H
H
H
H
H
0
25
15
H
10
H
H
H
H
H
H
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
20
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
389
390
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
6.06
7.13
8.78
(5.46 6.72)
(6.35 8.01)
(7.99 9.65)
(8.10 9.66)
(6.95 8.42)
(11.1 14.8)
(10.0 12.2)
(7.41 9.50)
(6.06 7.75)
(6.06 8.00)
(7.61 8.85)
.489
.570
.499
.710
.450
1.10
.998
.594
.385
.393
.499
(.496 .967)
(.300 .502)
(.794 1.49)
(.671 1.27)
(.357 .766)
(< LOD .491)
(< LOD .621)
(.468 .593)
.793
.846
.994
1.18
.715
1.95
1.62
.897
.559
.884
.953
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
8.85
7.65
12.8
11.1
8.39
6.85
6.96
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
8.21
(.585 .992)
(.693 1.02)
(.725 1.20)
(.986 1.28)
(.575 .892)
(1.25 2.17)
(1.28 1.88)
(.690 1.20)
(.468 .964)
(.591 1.02)
(.754 1.08)
5.87
6.82
9.15
9.07
7.49
13.2
10.8
8.80
6.37
7.07
8.33
(5.28 6.69)
(6.08 8.20)
(8.27 9.99)
(8.18 10.0)
(6.81 8.27)
(10.8 16.0)
(9.61 11.7)
(7.71 9.78)
(5.36 7.63)
(6.06 8.03)
(7.59 9.06)
46.2
48.5
69.8
67.2
64.4
84.9
72.2
71.7
56.2
51.4
64.8
(38.7 73.5)
(40.2 61.3)
(56.4 96.8)
(55.6 93.0)
(51.6 89.1)
(60.3 131)
(53.8 114)
(50.4 132)
(43.6 146)
(38.7 86.4)
(56.0 80.8)
107
78.3
242
147
257
140
148
200
314
150
205
(70.7 201)
(67.8 117)
(146 504)
(117 246)
(158 541)
(106 311)
(114 287)
(117 563)
(117 1,220)
(72.5 372)
(138 329)
1,287
1,340
2,106
2,492
2,625
692
1,422
1,137
897
969
5,117
Geometric mean and selected percentiles of urine concentrations (in g/L) for the total U.S. population aged 6 years and older, National Health and
Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
20
10
Females
Males
Urinary equol
(g/L)
30
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
20
10
0
Urinary equol
(g/L)
30
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
20
10
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary equol
(g/L)
30
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
391
8.21
12.8
11.1
8.39
6.85
6.96
(7.61 8.85)
(11.1 14.8)
(10.0 12.2)
(7.41 9.50)
(6.06 7.75)
(6.06 8.00)
1.49
2.75
2.61
1.50
1.28
1.30
(1.30 1.60)
(2.10 3.50)
(2.29 2.90)
(1.20 1.80)
(1.07 1.41)
(1.09 1.51)
8.33
13.2
10.8
8.80
6.37
7.07
(7.59 9.06)
(10.8 16.0)
(9.61 11.7)
(7.71 9.78)
(5.36 7.63)
(6.06 8.03)
36.7
45.5
42.8
36.5
33.3
32.0
(33.8 39.7)
(41.5 65.3)
(38.6 47.0)
(30.8 42.8)
(29.7 37.5)
(24.4 39.1)
5,117
692
1,422
1,137
897
969
8.85
15.0
12.0
8.42
7.16
8.22
(8.10 9.66)
(12.6 17.8)
(10.5 13.7)
(7.10 9.99)
(6.07 8.44)
(6.78 9.98)
1.60
3.79
2.67
1.47
1.42
1.50
(1.38 1.99)
(2.20 5.37)
(2.24 3.29)
(1.03 1.83)
(1.20 1.79)
(1.23 1.83)
9.07
16.4
11.7
8.70
7.44
8.44
(8.18 10.0)
(13.2 19.2)
(10.6 12.7)
(7.21 10.0)
(5.69 8.91)
(7.09 10.1)
38.6
50.1
44.8
41.3
30.0
36.2
(34.4 42.9)
(43.4 74.2)
(36.9 69.0)
(31.1 52.6)
(24.3 37.4)
(27.5 46.9)
2,492
340
728
499
447
478
7.65
10.9
10.1
8.36
6.58
6.10
(6.95 8.42)
(9.07 13.1)
(8.93 11.5)
(7.09 9.86)
(5.45 7.95)
(5.03 7.39)
1.30
2.43
2.49
1.50
.939
1.18
(1.19 1.50)
(1.59 2.80)
(1.87 2.83)
(1.06 1.97)
(.529 1.29)
(.974 1.40)
7.49
10.1
9.39
9.07
5.69
5.80
(6.81 8.27)
(9.16 12.5)
(8.03 11.4)
(7.09 10.6)
(4.68 6.95)
(5.20 7.32)
34.8
43.5
40.4
32.2
34.5
26.4
(32.1 38.7)
(35.0 69.5)
(34.8 47.1)
(28.2 40.7)
(30.9 45.9)
(19.2 40.6)
2,625
352
694
638
450
491
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
6.06
9.49
8.07
5.71
4.63
4.10
(5.46 6.72)
(7.78 11.6)
(7.04 9.24)
(4.97 6.56)
(3.73 5.75)
(3.21 5.23)
1.27
1.60
1.60
1.27
1.08
.631
(1.01 1.49)
(1.05 2.47)
(1.44 2.01)
(.967 1.51)
(< LOD 1.48)
(.379 .946)
5.87
9.20
7.08
5.59
4.99
4.73
(5.28 6.69)
(6.88 11.7)
(6.25 8.19)
(4.49 6.42)
(3.92 5.86)
(3.19 6.60)
25.8
45.5
35.7
21.9
19.0
16.6
(20.9 35.4)
(37.6 85.8)
(27.8 49.2)
(17.9 39.2)
(14.0 25.0)
(10.8 27.3)
1,287
231
445
282
157
172
5.92
10.1
8.75
4.81
5.22
4.36
(5.25 6.68)
(7.14 14.3)
(7.28 10.5)
(3.96 5.86)
(4.05 6.72)
(3.01 6.31)
1.29
2.17
1.83
1.15
1.18
.600
(1.04 1.57)
(.735 3.86)
(1.35 2.32)
(.685 1.41)
(.707 1.98)
(< LOD 1.47)
5.69
9.71
7.71
4.55
5.27
4.99
(4.89 6.81)
(6.15 14.4)
(6.15 9.42)
(3.70 6.03)
(4.28 6.94)
(3.05 6.89)
24.6
40.8
41.1
18.0
19.5
17.3
(19.8 32.9)
(26.9 88.4)
(28.6 61.8)
(12.6 40.6)
(12.5 31.6)
(9.44 65.3)
625
112
228
117
85
83
6.21
8.89
7.41
6.99
4.07
3.90
(5.35 7.22)
(6.62 11.9)
(6.32 8.69)
(5.35 9.13)
(2.94 5.64)
(2.50 6.08)
1.20
1.47
1.50
1.37
.861
.671
(.793 1.51)
(.569 2.34)
(.916 2.21)
(.689 1.85)
(< LOD 1.36)
(< LOD 1.12)
6.18
8.44
6.81
6.79
3.89
4.41
(5.15 7.09)
(5.75 11.4)
(5.51 8.03)
(4.70 9.31)
(2.93 5.72)
(2.15 7.53)
28.0
57.0
28.4
35.2
18.3
14.8
(20.7 39.6)
(37.3 202)
(19.3 52.0)
(19.6 66.9)
(14.0 34.4)
(9.40 80.2)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
392
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
7.13
11.9
9.86
7.03
5.91
4.79
(6.35 8.01)
(9.99 14.2)
(8.44 11.5)
(5.93 8.34)
(4.67 7.49)
(3.89 5.91)
1.49
3.00
2.40
1.50
1.19
.852
(1.28 1.70)
(2.09 3.59)
(1.99 2.78)
(1.01 2.10)
(.705 1.60)
(.685 1.10)
6.82
10.8
8.98
6.94
5.49
5.17
(6.08 8.20)
(8.53 14.0)
(7.83 10.3)
(5.91 9.58)
(4.44 7.21)
(4.14 6.24)
31.3
54.2
42.5
24.6
33.4
21.8
(27.1 36.6)
(40.6 79.7)
(35.2 61.4)
(21.6 32.3)
(21.8 45.8)
(17.1 30.7)
1,340
207
496
249
228
160
7.47
13.3
10.8
7.77
5.52
4.15
(6.72 8.30)
(10.4 17.1)
(8.60 13.5)
(6.53 9.24)
(4.14 7.35)
(3.25 5.29)
1.57
3.43
2.73
1.46
1.46
.758
(1.36 1.74)
(1.29 4.53)
(1.99 3.07)
(1.21 2.10)
(1.11 1.67)
(< LOD 1.27)
6.78
12.7
9.98
6.65
5.13
4.28
(5.94 8.18)
(9.66 14.9)
(7.56 12.6)
(5.38 9.46)
(4.01 7.66)
(3.25 5.82)
31.5
71.1
40.1
27.4
24.5
21.7
(27.0 39.4)
(35.1 125)
(32.6 70.0)
(23.1 45.5)
(13.5 51.5)
(10.8 66.2)
658
99
258
116
111
74
6.87
10.6
9.01
6.49
6.25
5.26
(5.87 8.04)
(7.95 14.2)
(7.47 10.9)
(5.06 8.33)
(4.47 8.74)
(4.08 6.78)
1.25
2.52
2.08
1.50
.702
.872
(.765 1.80)
(1.45 3.58)
(1.31 2.78)
(.605 2.40)
(.318 1.88)
(.723 1.03)
6.86
9.24
8.50
7.06
5.84
5.43
(5.92 8.46)
(6.86 12.6)
(7.01 9.53)
(4.83 10.1)
(4.69 8.20)
(3.80 8.00)
30.3
47.6
43.6
22.2
37.0
21.8
(25.2 37.5)
(30.5 124)
(31.4 71.3)
(17.7 30.1)
(24.8 63.0)
(17.4 37.7)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
8.78
14.7
12.1
9.62
7.04
7.65
(7.99 9.65)
(11.9 18.1)
(10.6 13.8)
(8.11 11.4)
(6.11 8.12)
(6.47 9.04)
1.54
3.40
3.09
1.57
1.29
1.46
(1.30 1.80)
(2.09 5.41)
(2.50 3.61)
(1.13 2.04)
(.848 1.49)
(1.17 1.88)
9.15
16.3
11.9
10.0
6.87
7.66
(8.27 9.99)
(12.7 18.8)
(10.6 13.6)
(8.77 11.7)
(5.37 8.81)
(6.29 8.72)
38.2
44.9
42.0
42.8
33.8
33.6
(34.4 43.0)
(38.1 78.1)
(36.7 46.5)
(32.6 57.5)
(30.8 37.4)
(25.9 47.8)
2,106
193
378
494
447
594
9.68
17.5
13.4
9.63
7.61
9.32
(8.71 10.8)
(13.8 22.2)
(11.3 16.0)
(7.72 12.0)
(6.19 9.35)
(7.43 11.7)
1.71
5.59
3.28
1.54
1.41
1.73
(1.40 2.10)
(2.11 6.02)
(1.89 4.54)
(1.00 2.07)
(1.08 1.91)
(1.27 2.50)
10.0
17.5
12.2
10.0
7.93
9.42
(8.94 11.1)
(13.5 24.4)
(11.3 15.4)
(8.68 11.5)
(5.97 9.71)
(7.36 12.1)
40.1
44.9
45.0
44.3
31.4
37.6
(36.0 45.2)
(39.9 115)
(36.6 79.1)
(32.4 82.8)
(26.6 42.6)
(30.7 55.2)
1,034
99
191
217
228
299
7.98
12.0
10.8
9.60
6.52
6.54
(7.02 9.06)
(8.61 16.7)
(8.95 13.0)
(7.63 12.1)
(5.18 8.20)
(5.19 8.25)
1.45
2.61
2.76
1.66
.967
1.27
(1.20 1.60)
(.948 3.85)
(1.92 3.64)
(.954 2.27)
(.492 1.32)
(.956 1.58)
7.86
12.3
11.1
10.3
6.18
6.08
(6.93 9.16)
(9.15 17.3)
(8.16 13.8)
(7.50 12.8)
(4.63 7.52)
(5.27 8.01)
35.6
43.2
39.9
37.3
33.9
29.4
(31.7 42.8)
(27.4 91.7)
(32.0 45.3)
(29.2 72.9)
(30.9 47.3)
(18.6 55.9)
1,072
94
187
277
219
295
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
393
8.37
9.17
8.02
8.40
(7.21 9.72)
(7.76 10.8)
(7.07 9.10)
(7.63 9.24)
< LOD
< LOD
.934
.878
10.4
12.2
12.4
13.3
(7.65 14.3)
(10.2 14.6)
(9.71 15.8)
(11.3 15.7)
< LOD
< LOD
1.92
1.90
10.9
10.2
10.6
11.6
(8.64 13.8)
(8.50 12.1)
(8.96 12.4)
(10.3 13.0)
< LOD
< LOD
1.64
1.49
7.66
9.35
8.81
8.00
(6.63 8.86)
(7.40 11.8)
(7.29 10.6)
(6.71 9.54)
< LOD
< LOD
.980
.820
7.80
8.92
6.65
7.05
(6.17 9.84)
(7.27 10.9)
(5.61 7.87)
(5.83 8.54)
< LOD
< LOD
.613
.542
8.04
7.18
6.16
7.84
(6.93 9.33)
(5.83 8.85)
(4.93 7.68)
(6.60 9.31)
< LOD
< LOD
.754
.940
9.15
9.41
8.56
9.13
(7.37 11.4)
(7.99 11.1)
(7.54 9.72)
(7.99 10.4)
< LOD
< LOD
1.07
1.19
7.70
8.94
7.55
7.75
(6.79 8.74)
(7.38 10.8)
(6.44 8.84)
(6.85 8.78)
< LOD
< LOD
.792
.684
5.24
7.22
6.08
6.04
(4.77 5.75)
(6.04 8.62)
(5.08 7.28)
(5.31 6.87)
< LOD
< LOD
.927
.663
6.67
7.11
7.32
6.96
(5.16 8.63)
(6.01 8.42)
(6.13 8.73)
(5.89 8.22)
< LOD
< LOD
.753
.868
9.38
9.89
8.51
9.05
(7.94 11.1)
(7.90 12.4)
(7.22 10.0)
(8.08 10.1)
< LOD
< LOD
.996
.965
(.655 1.11)
(.698 1.08)
8.00
8.94
7.98
8.60
(6.29 9.82)
(7.36 10.4)
(6.77 9.36)
(7.91 9.17)
53.7
73.5
64.8
64.5
(41.6 79.6)
(56.4 95.8)
(47.0 100)
(56.9 80.5)
2,182
2,794
2,590
2,527
(1.00 2.31)
(1.02 2.49)
11.5
13.7
12.0
13.4
(5.76 18.5)
(11.1 16.1)
(8.45 17.6)
(12.1 16.6)
55.4
84.5
85.4
70.3
(32.5 310)
(53.6 214)
(49.1 251)
(54.3 228)
272
396
341
351
(1.05 2.11)
(1.19 2.04)
10.7
10.4
10.5
11.2
(8.57 13.3)
(8.27 12.5)
(8.73 12.1)
(9.48 12.3)
71.6
68.9
61.8
81.6
(51.1 235)
(48.1 106)
(46.0 113)
(54.9 148)
657
744
729
693
(.509 1.31)
(.587 1.18)
7.55
9.25
9.11
8.60
(5.49 9.38)
(6.95 11.3)
(7.18 10.8)
(7.42 9.73)
38.1
67.0
99.6
57.1
(35.6 69.4)
(49.7 111)
(44.4 221)
(45.0 95.1)
439
604
554
583
(.372 1.04)
(.325 1.07)
7.28
8.12
6.09
6.76
(4.97 9.09)
(6.43 10.1)
(4.66 8.60)
(5.33 8.36)
53.7
102
51.6
63.8
(34.0 3,160)
(44.7 312)
(38.0 140)
(38.6 542)
378
531
448
449
7.33
5.68
5.88
7.80
(5.55 9.70)
(3.76 8.16)
(4.99 7.75)
(6.29 8.95)
54.8
51.0
39.6
55.5
(35.9 237)
(41.8 113)
(32.2 176)
(42.4 326)
436
519
518
451
(.861 1.26)
(.892 1.29)
8.44
9.14
8.70
9.40
(6.38 11.2)
(7.65 10.6)
(7.18 10.2)
(8.15 10.6)
68.8
61.4
72.3
61.7
(45.0 170)
(52.6 87.6)
(50.8 112)
(53.1 94.2)
1,042
1,375
1,240
1,252
(.480 1.02)
(.486 .877)
7.56
8.54
7.29
7.56
(5.92 8.98)
(6.72 10.6)
(6.12 8.96)
(6.93 8.36)
48.2
79.3
60.2
69.0
(37.6 70.9)
(58.9 130)
(43.8 145)
(54.8 119)
1,140
1,419
1,350
1,275
(.625 1.18)
(.440 .961)
4.51
6.49
5.64
6.12
(3.75 5.25)
(4.52 8.98)
(4.65 6.77)
(5.32 7.09)
30.3
42.1
43.5
47.6
(22.6 62.5)
(40.1 48.7)
(36.2 108)
(36.7 83.0)
726
679
653
634
(.505 1.11)
(.686 1.05)
6.12
6.00
7.85
6.37
(3.87 9.88)
(4.62 7.48)
(6.09 9.58)
(5.48 7.85)
36.5
45.2
46.9
48.6
(30.0 52.0)
(40.7 99.6)
(39.8 62.3)
(39.2 64.9)
504
692
678
662
(.618 1.19)
(.606 1.27)
8.98
9.93
8.72
9.48
(6.99 11.8)
(7.31 12.5)
(6.95 10.3)
(8.56 10.3)
56.1
74.1
72.9
68.9
(45.4 95.5)
(55.1 108)
(46.8 120)
(56.9 105)
744
1,211
1,068
1,038
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
394
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
400
95th Percentile
300
200
100
H
H
H
H
H
H
H
H
H
H
H
H
0
20
50th Percentile
15
H
H
10
H
H
H
H
H
H
H
H
H
H
H
0
2.5
H
H
1.5
H
H
1.0
H
H
H
H
H
H
0.5
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0.0
9900
0102
0304
0506
5th Percentile
2.0
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
395
396
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
5.46
5.02
8.94
(4.94 6.04)
(4.48 5.62)
(8.26 9.67)
(6.46 7.64)
(8.02 9.49)
(12.4 15.6)
(7.40 9.19)
(6.38 8.02)
(6.07 7.96)
(7.32 9.08)
(7.31 8.43)
.615
.533
.792
.634
.787
1.45
.948
.675
.538
.889
.724
(.462 .769)
(.705 .890)
(1.00 2.26)
(.501 1.34)
(.540 .776)
(< LOD .693)
(< LOD 1.11)
(.600 .799)
.867
.766
1.18
.942
1.18
2.51
1.49
.901
.792
1.33
1.05
(.674 1.04)
(.655 .917)
(1.07 1.38)
(.768 1.10)
(.964 1.39)
(1.79 3.00)
(1.13 1.81)
(.763 1.06)
(.629 1.08)
(1.11 1.52)
(.898 1.18)
4.84
4.88
8.65
6.84
8.36
14.4
8.04
7.06
6.57
8.13
7.64
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
7.02
8.72
13.9
8.24
7.15
6.95
8.16
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
7.85
(4.34 5.48)
(4.40 5.59)
(7.95 9.50)
(6.27 7.53)
(7.88 8.98)
(12.3 16.0)
(7.17 8.69)
(6.25 7.86)
(5.54 7.54)
(7.12 8.80)
(7.10 8.15)
37.9
30.5
69.4
51.8
70.0
92.0
48.2
63.7
66.0
45.3
58.1
(33.4 69.8)
(26.1 42.2)
(48.3 107)
(44.0 67.2)
(48.3 104)
(59.9 129)
(38.2 75.3)
(40.1 115)
(35.1 245)
(33.8 99.4)
(48.3 78.3)
129
64.8
267
129
356
136
118
210
421
140
219
(83.3 192)
(42.5 96.6)
(155 502)
(106 237)
(169 692)
(117 270)
(80.6 216)
(118 392)
(110 1,130)
(63.1 436)
(129 356)
1,287
1,340
2,106
2,492
2,625
692
1,422
1,137
897
969
5,117
Geometric mean and selected percentiles of urine concentrations (in g/g creatinine) for the total U.S. population aged 6 years and older, National
Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
20
5
10
15
Females
Males
Urinary equol
(g/g creatinine)
25
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
20
15
10
5
0
Urinary equol
(g/g creatinine)
25
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
20
5
10
15
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary equol
(g/g creatinine)
25
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
397
7.85
13.9
8.24
7.15
6.95
8.16
(7.31 8.43)
(12.4 15.6)
(7.40 9.19)
(6.38 8.02)
(6.07 7.96)
(7.32 9.08)
1.72
3.64
2.09
1.45
1.40
2.14
(1.54 1.90)
(2.88 4.34)
(1.87 2.39)
(1.17 1.73)
(1.14 1.60)
(1.86 2.43)
7.64
14.4
8.04
7.06
6.57
8.13
(7.10 8.15)
(12.3 16.0)
(7.17 8.69)
(6.25 7.86)
(5.54 7.54)
(7.12 8.80)
30.7
44.9
31.3
29.5
25.6
27.1
(28.8 32.6)
(40.5 57.6)
(26.0 35.0)
(23.7 34.6)
(21.3 34.3)
(21.6 34.0)
5,117
692
1,422
1,137
897
969
7.02
15.0
8.15
6.14
5.69
7.58
(6.46 7.64)
(12.9 17.5)
(7.01 9.47)
(5.31 7.10)
(4.78 6.77)
(6.47 8.88)
1.48
3.84
1.92
1.26
1.18
1.87
(1.28 1.76)
(3.12 4.90)
(1.72 2.25)
(.981 1.47)
(.790 1.58)
(1.37 2.25)
6.84
16.1
8.15
5.83
5.53
7.28
(6.27 7.53)
(14.7 19.0)
(6.93 9.51)
(4.99 6.67)
(4.55 6.67)
(6.43 8.67)
28.8
45.4
31.3
25.2
21.8
28.8
(25.7 31.7)
(37.2 90.4)
(25.8 47.4)
(20.0 34.6)
(15.9 33.7)
(20.8 34.1)
2,492
340
728
499
447
478
8.72
12.8
8.35
8.32
8.39
8.65
(8.02 9.49)
(11.0 15.0)
(7.44 9.37)
(7.03 9.84)
(7.05 9.98)
(7.36 10.2)
1.95
3.24
2.33
1.87
1.51
2.41
(1.67 2.16)
(2.47 4.43)
(1.89 2.72)
(1.20 2.15)
(1.19 1.86)
(2.00 2.83)
8.36
12.8
7.94
8.08
7.92
8.44
(7.88 8.98)
(10.1 14.7)
(7.03 8.71)
(7.13 9.13)
(6.51 9.40)
(7.65 9.39)
32.3
44.8
30.5
32.2
31.4
26.8
(30.1 34.9)
(39.8 57.7)
(22.8 37.1)
(25.0 38.8)
(24.1 43.1)
(20.4 39.8)
2,625
352
694
638
450
491
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
5.46
11.9
6.23
4.61
4.24
5.06
(4.94 6.04)
(10.4 13.7)
(5.49 7.07)
(3.91 5.42)
(3.57 5.04)
(4.22 6.06)
1.29
2.42
1.62
1.12
1.23
1.46
(1.14 1.43)
(1.84 4.06)
(1.35 1.73)
(.736 1.37)
(< LOD 1.43)
(.752 1.97)
4.84
10.9
5.57
4.10
4.11
4.82
(4.34 5.48)
(8.91 13.8)
(4.69 6.09)
(3.26 4.90)
(3.40 4.80)
(3.84 6.04)
22.4
58.9
25.3
19.6
14.0
19.0
(19.7 27.6)
(30.4 121)
(19.7 34.5)
(15.2 31.0)
(11.8 27.0)
(10.5 61.0)
1,287
231
445
282
157
172
4.67
12.1
6.33
3.50
3.83
3.88
(4.08 5.35)
(9.02 16.2)
(5.37 7.48)
(2.79 4.38)
(3.11 4.70)
(2.81 5.35)
1.16
3.55
1.60
.804
1.27
1.16
(.883 1.34)
(1.73 4.93)
(1.35 1.82)
(.519 1.20)
(.640 1.40)
(< LOD 1.91)
4.23
10.6
5.58
3.42
3.78
4.17
(3.78 5.04)
(8.24 16.2)
(4.35 6.84)
(2.99 4.15)
(3.16 4.90)
(3.23 5.83)
18.9
35.9
27.5
11.5
11.4
10.5
(16.3 21.2)
(27.4 108)
(19.6 43.7)
(7.33 21.7)
(8.79 26.7)
(7.12 60.1)
625
112
228
117
85
83
6.48
11.7
6.12
6.39
4.74
6.28
(5.83 7.21)
(9.26 14.8)
(5.10 7.36)
(5.00 8.15)
(3.71 6.04)
(4.18 9.43)
1.57
2.14
1.59
1.62
.933
1.82
(1.37 1.84)
(1.07 3.77)
(1.13 1.80)
(1.14 2.09)
(< LOD 1.67)
(< LOD 2.38)
5.75
10.9
5.50
5.39
4.23
5.43
(4.93 6.55)
(8.65 13.4)
(4.49 6.06)
(4.01 7.25)
(3.33 5.37)
(3.77 8.92)
29.0
88.9
24.0
30.4
21.0
24.4
(24.0 34.5)
(28.8 177)
(15.6 40.4)
(19.7 58.3)
(13.1 31.3)
(11.9 201)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
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2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
5.02
11.2
5.66
4.36
4.33
4.28
(4.48 5.62)
(9.38 13.3)
(4.86 6.60)
(3.81 4.98)
(3.36 5.58)
(3.53 5.19)
1.19
3.12
1.45
1.02
1.02
1.08
(1.02 1.41)
(2.54 3.56)
(1.14 1.68)
(.802 1.36)
(.520 1.41)
(.798 1.38)
4.88
9.67
5.37
4.87
4.06
4.22
(4.40 5.59)
(7.96 11.3)
(4.61 6.33)
(4.24 5.64)
(2.87 5.29)
(3.62 5.09)
20.8
47.8
21.5
12.3
19.7
16.7
(18.2 23.7)
(34.3 64.1)
(16.8 27.9)
(10.8 17.6)
(16.8 25.8)
(13.6 23.6)
1,340
207
496
249
228
160
4.37
12.6
5.77
3.73
3.18
3.04
(3.86 4.95)
(9.98 15.9)
(4.53 7.34)
(3.09 4.50)
(2.40 4.21)
(2.42 3.82)
1.01
3.44
1.45
.892
.865
.742
(.775 1.18)
(1.39 4.49)
(.957 1.76)
(.630 1.05)
(.471 1.24)
(< LOD .959)
4.24
11.0
5.39
3.82
2.92
3.22
(3.60 4.97)
(8.57 14.3)
(4.19 6.65)
(3.14 5.00)
(2.24 4.31)
(2.07 4.15)
19.1
52.6
21.7
12.1
11.6
13.5
(15.2 23.4)
(28.7 99.7)
(15.8 36.8)
(10.5 15.9)
(6.28 27.1)
(9.29 22.1)
658
99
258
116
111
74
5.63
9.92
5.56
4.94
5.55
5.31
(4.95 6.40)
(7.41 13.3)
(4.61 6.70)
(4.12 5.92)
(3.94 7.81)
(4.14 6.80)
1.41
2.69
1.43
1.34
1.12
1.51
(1.18 1.59)
(1.59 3.38)
(1.03 1.81)
(.768 1.89)
(.501 1.51)
(1.22 1.63)
5.45
8.60
5.30
5.12
5.32
4.81
(4.77 6.45)
(6.65 11.1)
(4.05 7.15)
(4.53 6.44)
(3.42 7.37)
(3.98 6.91)
22.1
43.5
20.9
12.3
24.3
19.3
(18.5 25.5)
(30.1 68.7)
(16.0 28.0)
(10.8 20.2)
(18.4 65.6)
(14.1 32.3)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
8.94
16.0
9.48
8.87
7.58
9.12
(8.26 9.67)
(13.4 19.0)
(8.25 10.9)
(7.54 10.4)
(6.57 8.75)
(8.02 10.4)
2.12
4.07
2.75
1.95
1.51
2.55
(1.87 2.32)
(2.54 5.84)
(1.97 3.28)
(1.28 2.31)
(1.15 2.02)
(2.13 2.94)
8.65
17.1
9.27
8.50
7.18
8.66
(7.95 9.50)
(14.2 20.0)
(8.04 10.9)
(7.25 9.93)
(6.03 8.73)
(7.89 9.39)
32.4
44.8
32.1
33.2
26.5
29.1
(30.4 34.8)
(39.0 81.4)
(26.2 38.2)
(26.3 55.1)
(21.7 35.0)
(22.3 38.7)
2,106
193
378
494
447
594
8.10
17.0
9.58
7.64
6.38
8.68
(7.34 8.94)
(13.8 20.9)
(7.86 11.7)
(6.35 9.19)
(5.14 7.92)
(7.23 10.4)
1.91
4.06
2.18
1.59
1.17
2.36
(1.41 2.23)
(2.35 6.86)
(1.78 3.30)
(1.13 2.24)
(.741 2.01)
(1.85 2.71)
7.87
18.4
9.53
7.09
6.44
8.31
(6.92 8.89)
(15.2 21.9)
(7.67 11.5)
(6.21 9.30)
(4.85 7.62)
(6.94 9.56)
30.4
44.2
32.8
28.9
23.5
29.0
(27.1 33.9)
(34.9 132)
(26.7 59.8)
(21.8 47.5)
(17.7 53.0)
(21.6 39.1)
1,034
99
191
217
228
299
9.84
14.8
9.37
10.3
9.02
9.49
(8.90 10.9)
(11.2 19.7)
(7.98 11.0)
(8.07 13.1)
(7.44 10.9)
(7.84 11.5)
2.32
4.05
3.02
2.14
1.67
2.84
(2.00 2.77)
(.890 6.10)
(2.28 3.55)
(1.19 2.98)
(1.22 2.59)
(2.12 3.20)
9.24
14.1
8.70
9.09
8.68
8.89
(8.62 10.3)
(11.8 18.0)
(7.53 11.0)
(8.00 11.7)
(6.70 12.1)
(8.06 10.1)
34.0
44.8
30.7
38.3
31.7
29.4
(30.6 39.7)
(36.8 90.7)
(21.3 37.5)
(29.8 75.9)
(21.7 44.0)
(21.0 49.8)
1,072
94
187
277
219
295
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
399
7.70
8.60
7.52
8.18
(6.82 8.70)
(7.26 10.2)
(6.83 8.29)
(7.33 9.14)
<LOD
<LOD
1.01
1.08
10.3
13.9
13.2
14.7
(7.82 13.5)
(11.2 17.2)
(10.9 15.9)
(12.6 17.1)
<LOD
<LOD
2.59
2.41
7.61
7.83
7.90
8.61
(6.17 9.39)
(6.68 9.17)
(6.59 9.49)
(7.53 9.83)
<LOD
<LOD
1.41
1.60
6.20
7.56
7.42
6.90
(5.22 7.38)
(6.16 9.27)
(6.36 8.66)
(5.76 8.27)
<LOD
<LOD
.902
.887
7.84
8.86
6.40
7.51
(6.30 9.76)
(7.19 10.9)
(5.47 7.49)
(6.01 9.39)
<LOD
<LOD
.777
.895
9.72
8.50
7.28
9.09
(8.33 11.3)
(7.02 10.3)
(6.19 8.56)
(7.93 10.4)
<LOD
<LOD
1.27
1.38
7.01
7.66
6.71
7.35
(5.93 8.29)
(6.39 9.18)
(6.02 7.47)
(6.40 8.43)
<LOD
<LOD
.912
.984
8.41
9.60
8.38
9.07
(7.33 9.66)
(7.99 11.5)
(7.39 9.51)
(8.04 10.2)
<LOD
<LOD
1.15
1.24
4.89
6.79
5.48
5.45
(4.36 5.47)
(5.82 7.92)
(4.60 6.54)
(4.84 6.14)
<LOD
<LOD
.932
.738
4.31
4.96
5.17
4.88
(3.36 5.52)
(4.19 5.86)
(4.38 6.10)
(4.11 5.78)
<LOD
<LOD
.759
.769
9.31
9.77
8.39
9.51
(8.01 10.8)
(7.86 12.1)
(7.46 9.43)
(8.48 10.7)
<LOD
<LOD
1.11
1.31
(.861 1.18)
(.861 1.31)
7.96
7.98
7.29
7.92
(6.93 9.34)
(6.64 9.71)
(6.56 8.18)
(7.01 8.75)
50.0
62.5
50.1
67.5
(43.2 67.5)
(52.1 87.0)
(39.9 75.5)
(48.6 104)
2,182
2,794
2,590
2,527
(1.57 3.11)
(1.21 3.27)
11.3
14.0
12.9
15.3
(7.61 16.0)
(10.6 17.0)
(9.20 17.4)
(13.7 17.4)
46.6
80.8
93.4
87.6
(33.5 151)
(59.5 211)
(49.7 134)
(57.6 267)
272
396
341
351
(.856 1.87)
(1.28 1.87)
7.94
7.76
8.11
8.03
(6.84 9.24)
(6.30 9.13)
(6.82 9.03)
(7.15 9.27)
47.2
52.6
40.4
60.5
(28.6 243)
(36.0 160)
(32.8 100)
(37.4 141)
657
744
729
693
(.750 1.26)
(.644 1.06)
6.32
6.83
6.88
7.09
(5.37 7.59)
(5.60 8.78)
(5.90 7.89)
(5.80 8.37)
34.1
53.5
104
47.2
(30.5 50.5)
(39.0 126)
(37.2 238)
(32.9 171)
439
604
554
583
(.615 1.05)
(.343 1.34)
8.06
7.83
6.54
6.61
(6.05 9.76)
(6.18 9.71)
(5.03 7.69)
(5.24 8.53)
69.0
81.9
38.1
108
(41.9 1,680)
(55.3 138)
(24.2 534)
(35.1 734)
378
531
448
449
(<LOD 1.52)
(1.09 1.82)
9.63
7.78
7.63
8.40
(7.42 11.3)
(6.48 10.1)
(6.22 8.79)
(7.49 9.42)
80.7
63.7
33.7
51.1
(41.1 448)
(38.1 161)
(24.8 256)
(34.1 291)
436
519
518
451
(.762 1.09)
(.599 1.25)
7.31
7.43
6.62
7.02
(5.71 8.74)
(5.83 9.14)
(5.80 7.28)
(5.94 8.63)
53.8
53.9
51.0
57.4
(38.9 88.4)
(40.7 75.8)
(38.7 76.6)
(43.3 85.6)
1,042
1,375
1,240
1,252
(.893 1.53)
(.885 1.41)
8.71
8.66
8.29
8.48
(7.52 10.2)
(7.02 10.6)
(7.08 9.29)
(7.90 9.19)
46.2
84.6
45.4
83.5
(43.1 55.6)
(62.4 118)
(39.0 103)
(53.4 165)
1,140
1,419
1,350
1,275
(.609 1.17)
(.548 1.02)
4.73
6.81
4.69
4.98
(3.90 5.23)
(5.66 8.02)
(4.02 5.77)
(4.38 5.85)
37.0
41.2
35.5
39.4
(26.7 62.3)
(34.5 54.2)
(29.2 113)
(31.9 81.2)
726
679
653
634
(.484 .958)
(.595 1.02)
4.54
4.37
5.18
4.72
(2.90 6.22)
(3.70 5.41)
(4.67 5.97)
(3.58 5.98)
25.8
35.2
29.7
31.0
(20.3 33.3)
(25.4 47.4)
(24.9 51.5)
(25.4 53.3)
504
692
678
662
(.914 1.35)
(1.03 1.68)
9.57
9.14
8.17
9.15
(7.91 11.2)
(7.06 12.1)
(7.13 9.23)
(8.06 10.5)
56.2
65.9
56.0
77.4
(46.6 73.0)
(56.8 85.0)
(38.7 116)
(48.6 146)
744
1,211
1,068
1,038
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
400
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
300
200
100
j
j
j
j
j
j
j
j
j
j
j
j
j
0
20
50th Percentile
15
j
j
j
10
j
j
j
j
j
j
j
0
4
2
j
j
j
j
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
401
402
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2.79
5.69
4.99
(2.29 3.39)
(4.70 6.90)
(4.55 5.46)
(4.29 5.63)
(4.26 5.18)
(5.30 8.59)
(6.18 8.74)
(3.52 4.86)
(3.81 5.13)
(3.69 5.30)
(4.42 5.22)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.233
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
4.92
4.70
6.74
7.35
4.13
4.42
4.42
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
4.80
1.93
4.56
4.35
4.21
3.92
6.17
6.38
3.32
3.88
3.71
4.09
(1.34 2.62)
(3.88 5.72)
(3.90 5.12)
(3.60 5.20)
(3.35 4.56)
(4.56 8.88)
(5.25 8.33)
(2.79 3.90)
(2.93 5.02)
(2.97 4.90)
(3.67 4.53)
147
279
245
223
283
231
285
242
261
191
251
(108 226)
(208 378)
(201 339)
(190 299)
(209 406)
(164 371)
(229 451)
(165 400)
(203 481)
(128 404)
(216 322)
304
531
525
476
649
445
607
485
657
455
524
(227 422)
(384 877)
(433 696)
(383 563)
(455 938)
(361 547)
(406 1,010)
(402 651)
(385 1,150)
(341 928)
(462 612)
1,286
1,342
2,100
2,492
2,617
692
1,422
1,129
899
967
5,109
Geometric mean and selected percentiles of urine concentrations (in g/L) for the total U.S. population aged 6 years and older, National Health and
Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
Mexican Americans
20
Overall
10
15
Females
Males
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
10
15
20
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
20
Females
2039
10
15
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary Odesmethylangolensin
(g/L)
Urinary Odesmethylangolensin
(g/L)
Urinary Odesmethylangolensin
(g/L)
Geometric mean (95% confidence interval), National Health and Nutrition Examination Survey, 20032006
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
403
4.80
6.74
7.35
4.13
4.42
4.42
(4.42 5.22)
(5.30 8.59)
(6.18 8.74)
(3.52 4.86)
(3.81 5.13)
(3.69 5.30)
.243
.472
.397
.228
< LOD
.237
(.210 .276)
(.297 .655)
(.300 .479)
(< LOD .276)
(< LOD .293)
4.09
6.17
6.38
3.32
3.88
3.71
(3.67 4.53)
(4.56 8.88)
(5.25 8.33)
(2.79 3.90)
(2.93 5.02)
(2.97 4.90)
97.6
107
108
86.5
114
84.9
(88.0 115)
(74.1 159)
(89.5 171)
(65.6 136)
(71.0 181)
(60.5 116)
5,109
692
1,422
1,129
899
967
4.92
6.83
9.13
4.38
4.04
4.39
(4.29 5.63)
(4.77 9.78)
(7.17 11.6)
(3.41 5.61)
(3.27 4.99)
(3.39 5.69)
.280
.501
.433
.213
.278
.261
(.231 .328)
(.234 .705)
(.341 .546)
(< LOD .299)
(.207 .339)
(< LOD .363)
4.21
5.60
8.73
3.63
3.34
4.05
(3.60 5.20)
(3.59 9.19)
(6.49 11.5)
(3.06 4.49)
(2.48 4.96)
(3.01 5.43)
91.2
117
127
89.8
69.6
75.8
(73.4 117)
(69.6 238)
(102 253)
(63.3 175)
(52.0 138)
(54.6 103)
2,492
340
728
498
451
475
4.70
6.65
5.83
3.91
4.82
4.45
(4.26 5.18)
(5.16 8.58)
(4.79 7.10)
(3.12 4.89)
(3.87 6.01)
(3.52 5.62)
.213
.392
.324
.244
< LOD
.224
3.92
6.91
4.28
2.83
4.46
3.45
(3.35 4.56)
(4.76 9.15)
(3.15 5.79)
(2.02 3.94)
(3.00 6.43)
(2.71 5.36)
105
100
92.9
80.6
181
88.7
(80.6 151)
(60.7 158)
(71.4 104)
(58.4 155)
(99.3 275)
(59.8 153)
2,617
352
694
631
448
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
2.79
6.57
6.38
1.92
1.91
2.15
(2.29 3.39)
(4.75 9.07)
(4.66 8.73)
(1.45 2.53)
(1.41 2.59)
(1.43 3.23)
< LOD
.446
.324
< LOD
< LOD
< LOD
2.83
7.12
6.77
1.71
2.46
2.19
(2.20 3.65)
(4.64 10.9)
(4.40 10.4)
(1.16 2.51)
(1.55 3.91)
(1.09 4.41)
< LOD
.506
.365
< LOD
< LOD
< LOD
2.74
6.03
5.99
2.20
1.45
2.12
(2.17 3.45)
(4.19 8.68)
(4.33 8.29)
(1.33 3.63)
(.886 2.38)
(1.13 3.98)
< LOD
.378
.302
< LOD
< LOD
< LOD
(.306 .603)
(.213 .396)
1.93
6.92
5.77
1.06
1.21
1.47
(1.34 2.62)
(3.88 11.0)
(4.16 8.32)
(.693 1.53)
(.806 2.20)
(.853 2.99)
62.4
103
134
58.2
31.7
27.9
(50.0 89.5)
(58.3 189)
(87.6 271)
(24.5 110)
(21.3 70.6)
(17.2 50.3)
1,286
231
445
281
157
172
1.92
7.04
6.56
.783
1.80
1.39
(1.23 2.79)
(2.90 15.9)
(3.54 11.1)
(.607 1.47)
(.755 3.23)
(.695 5.52)
61.5
115
122
39.2
48.1
21.6
(47.3 89.9)
(61.2 275)
(55.4 286)
(18.1 121)
(21.9 342)
(14.0 607)
625
112
228
117
85
83
1.97
6.65
4.71
1.31
1.06
1.45
(1.27 2.85)
(3.89 10.5)
(3.81 7.61)
(.772 2.43)
(.513 1.97)
(.808 4.19)
64.9
81.9
176
63.7
20.7
38.7
(39.2 111)
(32.7 296)
(93.4 325)
(19.3 235)
(10.1 73.1)
(11.3 1,390)
661
119
217
164
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
(.307 .700)
(.241 .462)
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
(.290 .531)
(< LOD .381)
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
404
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
5.69
10.6
9.85
4.31
5.54
3.60
(4.70 6.90)
(7.76 14.4)
(8.13 11.9)
(3.05 6.07)
(4.02 7.64)
(2.02 6.39)
.267
.639
.565
< LOD
.265
.215
6.62
11.9
11.4
6.79
4.89
2.91
(5.17 8.47)
(7.59 18.6)
(8.83 14.7)
(3.90 11.8)
(3.12 7.67)
(1.60 5.30)
5.01
9.36
8.51
2.98
6.15
4.11
(3.87 6.50)
(6.05 14.5)
(6.68 10.8)
(1.78 5.01)
(3.81 9.90)
(1.92 8.80)
(.210 .342)
(.244 1.24)
(.391 .896)
(< LOD .380)
(< LOD .279)
4.56
11.1
10.2
3.25
4.61
2.57
(3.88 5.72)
(7.91 16.4)
(7.23 15.0)
(2.16 4.64)
(2.91 7.10)
(1.49 4.67)
113
164
121
90.8
124
82.6
(89.0 157)
(106 338)
(100 172)
(51.6 170)
(80.1 220)
(47.3 341)
1,342
207
496
249
231
159
.297
.854
.580
.226
.244
.212
(.206 .458)
(.360 1.53)
(.376 .969)
(< LOD .614)
(< LOD .474)
(< LOD .298)
5.48
10.8
12.7
4.57
4.83
2.70
(4.13 8.91)
(5.47 20.0)
(7.98 17.0)
(2.91 12.9)
(2.15 9.22)
(1.05 4.21)
114
182
145
122
69.3
48.7
(90.2 168)
(106 764)
(111 241)
(82.3 400)
(46.5 216)
(20.0 868)
660
99
258
116
114
73
.246
.364
.551
< LOD
.280
.217
4.09
11.9
7.87
2.17
4.44
2.45
(2.94 5.38)
(7.46 16.4)
(5.52 14.0)
(1.14 4.46)
(2.60 8.52)
(1.37 8.03)
112
121
98.0
49.2
203
91.7
(82.0 160)
(56.0 502)
(77.3 143)
(27.2 160)
(106 486)
(67.0 322)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
(.207 .388)
(< LOD .363)
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
4.99
6.20
7.55
4.64
4.54
4.67
(4.55 5.46)
(4.18 9.18)
(5.92 9.63)
(3.67 5.85)
(3.75 5.51)
(3.89 5.60)
.247
.443
.401
.264
< LOD
.248
(.201 .293)
(< LOD .679)
(.259 .571)
(< LOD .331)
(< LOD .320)
4.35
5.49
6.85
3.71
4.14
4.09
(3.90 5.12)
(3.39 9.17)
(5.13 9.64)
(2.94 5.33)
(2.91 5.62)
(3.25 5.34)
97.9
95.4
103
104
121
84.4
(86.2 123)
(60.4 203)
(85.0 205)
(65.2 161)
(67.5 185)
(57.6 117)
2,100
193
378
488
447
594
4.88
5.78
9.72
4.46
4.09
4.58
(4.11 5.80)
(3.26 10.3)
(7.00 13.5)
(3.13 6.36)
(3.19 5.24)
(3.35 6.27)
.290
.445
.429
.236
.294
.266
(.217 .350)
(< LOD .719)
(.295 .611)
(< LOD .365)
(.201 .354)
(< LOD .384)
4.21
4.99
9.13
3.56
3.02
4.17
(3.40 5.41)
(1.97 10.4)
(6.14 13.6)
(2.79 5.63)
(2.28 5.24)
(3.21 6.29)
88.8
88.6
125
78.4
70.4
72.6
(67.8 120)
(40.8 580)
(88.5 365)
(48.1 189)
(51.0 170)
(50.6 103)
1,034
99
191
217
229
298
5.09
6.72
5.73
4.83
5.06
4.74
(4.45 5.82)
(4.42 10.2)
(4.21 7.80)
(3.50 6.66)
(3.68 6.95)
(3.78 5.94)
.209
.438
.299
.295
< LOD
.237
4.53
6.05
3.99
3.90
5.51
3.90
(3.79 5.58)
(3.68 12.2)
(2.90 8.09)
(2.73 6.07)
(2.99 7.16)
(2.86 6.17)
112
105
88.8
114
181
85.9
(74.9 175)
(48.1 310)
(61.2 170)
(58.4 303)
(67.3 333)
(53.0 168)
1,066
94
187
271
218
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
405
4.39
4.08
4.91
4.70
(3.37 5.73)
(3.53 4.73)
(4.34 5.55)
(4.17 5.31)
< LOD
< LOD
< LOD
< LOD
4.97
3.30
4.55
3.70
(3.67 6.74)
(2.64 4.11)
(3.99 5.16)
(3.14 4.25)
218
260
229
264
(186 247)
(177 492)
(186 364)
(213 386)
2,271
2,794
2,581
2,528
5.60
6.19
6.32
7.20
(3.85 8.15)
(4.51 8.49)
(4.30 9.30)
(5.20 9.96)
< LOD
< LOD
.319
< LOD
7.48
5.85
6.07
6.16
(3.42 15.1)
(3.88 9.42)
(3.48 10.5)
(3.98 10.9)
175
278
137
356
(79.4 273)
(177 522)
(92.3 283)
(207 506)
287
396
341
351
6.04
5.92
6.36
8.50
(3.76 9.70)
(4.46 7.86)
(4.95 8.18)
(6.48 11.2)
< LOD
< LOD
< LOD
.244
7.58
5.19
5.27
8.06
(5.18 13.2)
(3.72 7.59)
(3.89 8.00)
(5.57 11.6)
194
298
256
380
(136 301)
(179 435)
(179 416)
(168 869)
667
744
729
693
4.00
3.36
4.25
4.03
(2.73 5.86)
(2.61 4.34)
(3.24 5.58)
(3.29 4.93)
< LOD
< LOD
< LOD
< LOD
4.44
2.48
3.65
3.00
(2.77 5.87)
(1.80 3.00)
(2.74 4.89)
(2.17 3.78)
306
248
317
235
(252 462)
(128 680)
(154 483)
(154 336)
481
604
546
583
4.20
5.07
5.13
3.84
(3.13 5.62)
(3.45 7.46)
(4.34 6.07)
(2.97 4.97)
< LOD
< LOD
< LOD
< LOD
4.24
4.39
5.13
2.92
(2.78 6.11)
(2.61 7.20)
(3.52 6.44)
(1.72 4.29)
171
381
222
274
(119 304)
(206 1,000)
(180 753)
(214 587)
365
531
450
449
3.93
2.32
4.17
4.68
(2.75 5.62)
(1.83 2.94)
(3.09 5.63)
(3.70 5.91)
< LOD
< LOD
< LOD
< LOD
4.80
1.73
3.69
3.76
(3.04 8.37)
(1.16 2.30)
(2.71 5.88)
(2.74 5.45)
111
98.3
203
171
(74.5 185)
(70.6 464)
(129 394)
(92.6 486)
471
519
515
452
4.97
3.81
4.90
4.93
(3.71 6.66)
(3.08 4.71)
(3.93 6.12)
(4.13 5.89)
< LOD
< LOD
< LOD
< LOD
5.62
3.29
4.53
3.99
(4.23 8.78)
(2.52 4.38)
(3.32 5.49)
(3.34 5.43)
234
194
221
234
(180 332)
(134 356)
(163 359)
(178 341)
1,087
1,375
1,240
1,252
3.92
4.36
4.91
4.50
(2.97 5.16)
(3.64 5.23)
(4.26 5.66)
(3.90 5.20)
< LOD
< LOD
< LOD
< LOD
4.22
3.34
4.59
3.29
(3.24 5.48)
(2.47 4.50)
(3.91 5.51)
(2.71 4.24)
191
377
277
283
(149 245)
(232 750)
(168 450)
(199 499)
1,184
1,419
1,341
1,276
2.40
2.44
2.54
3.04
(1.55 3.73)
(1.51 3.94)
(1.86 3.48)
(2.29 4.05)
< LOD
< LOD
< LOD
< LOD
2.14
1.38
1.85
2.00
(1.40 3.43)
(.501 3.33)
(.928 3.30)
(1.36 2.84)
191
151
141
151
(128 323)
(80.1 498)
(105 272)
(95.3 271)
721
679
652
634
5.75
5.38
5.55
5.83
(4.60 7.20)
(4.01 7.21)
(4.07 7.57)
(4.49 7.58)
< LOD
< LOD
< LOD
< LOD
8.78
5.19
4.21
4.84
(5.90 10.9)
(3.04 7.31)
(3.25 6.49)
(3.94 6.45)
184
308
219
292
(138 320)
(193 430)
(182 375)
(173 471)
527
692
680
662
4.53
4.13
5.28
4.72
(3.23 6.37)
(3.44 4.96)
(4.65 5.99)
(4.09 5.45)
< LOD
< LOD
< LOD
< LOD
4.98
3.35
5.23
3.72
(3.38 7.14)
(2.61 4.32)
(4.53 5.78)
(3.21 4.59)
225
261
242
246
(189 255)
(178 546)
(186 407)
(184 391)
810
1,211
1,061
1,039
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
406
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
1000
95th Percentile
800
600
400
200
H
H
H
H
H
H
0
20
50th Percentile
15
10
H
H
H
H
H
H
H
H
H
H
H
H
0
800
400
200
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
600
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
407
408
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2.51
4.00
5.07
(2.01 3.14)
(3.35 4.77)
(4.68 5.49)
(3.42 4.44)
(4.85 5.91)
(5.72 9.33)
(4.64 6.46)
(3.05 4.04)
(3.89 5.16)
(4.38 6.13)
(4.25 4.94)
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
< LOD
.349
< LOD
< LOD
< LOD
< LOD
< LOD
(< LOD .470)
1.68
3.47
4.30
3.41
4.40
6.11
4.67
3.10
3.51
4.37
3.89
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
3.90
5.35
7.31
5.47
3.51
4.48
5.18
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
4.58
(1.09 2.45)
(2.48 4.61)
(3.85 4.69)
(2.81 4.09)
(3.76 5.25)
(4.49 8.22)
(3.74 6.52)
(2.38 3.74)
(2.96 4.33)
(3.42 5.80)
(3.51 4.33)
130
180
227
179
271
243
201
181
243
239
204
(93.0 158)
(136 313)
(194 274)
(144 227)
(202 396)
(175 349)
(136 375)
(144 260)
(194 532)
(140 389)
(193 260)
243
512
557
325
738
362
456
425
795
480
530
(164 423)
(292 876)
(338 824)
(256 482)
(548 1,020)
(317 611)
(270 713)
(241 646)
(343 1,270)
(317 1,730)
(376 725)
1,286
1,342
2,100
2,492
2,617
692
1,422
1,129
899
967
5,109
Geometric mean and selected percentiles of urine concentrations (in g/g creatinine) for the total U.S. population aged 6 years and older, National
Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
Mexican Americans
20
Overall
10
15
Females
Males
611
1219
2039
4059
60+
611
NonHispanic Blacks
1219
2039
4059
60+
10
15
20
NonHispanic Whites
611
1219
2039
4059
60+
611
1219
4059
60+
Males
20
Females
2039
10
15
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary Odesmethylangolensin
(g/g creatinine)
Urinary Odesmethylangolensin
(g/g creatinine)
Urinary Odesmethylangolensin
(g/g creatinine)
Geometric mean (95% confidence interval), National Health and Nutrition Examination Survey, 20032006
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
409
4.58
7.31
5.47
3.51
4.48
5.18
(4.25 4.94)
(5.72 9.33)
(4.64 6.46)
(3.05 4.04)
(3.89 5.16)
(4.38 6.13)
.312
.587
.320
.248
< LOD
.384
(.289 .338)
(.389 .800)
(.289 .402)
(< LOD .299)
(< LOD .472)
3.89
6.11
4.67
3.10
3.51
4.37
(3.51 4.33)
(4.49 8.22)
(3.74 6.52)
(2.38 3.74)
(2.96 4.33)
(3.42 5.80)
93.2
109
86.1
78.0
138
79.2
(81.6 109)
(84.7 165)
(61.4 129)
(63.1 97.3)
(76.1 190)
(65.8 119)
5,109
692
1,422
1,129
899
967
3.90
6.85
6.19
3.19
3.20
4.03
(3.42 4.44)
(4.87 9.63)
(4.90 7.82)
(2.53 4.03)
(2.57 3.99)
(3.22 5.05)
.281
.496
.315
.196
.251
.341
(.233 .323)
(.308 .801)
(.219 .487)
(< LOD .283)
(.200 .312)
(< LOD .424)
3.41
5.45
6.40
2.68
2.76
3.75
(2.81 4.09)
(3.39 8.21)
(4.16 8.62)
(2.00 4.15)
(2.03 3.84)
(2.54 5.01)
73.1
126
94.4
67.3
51.5
64.8
(58.7 85.3)
(81.4 215)
(61.8 169)
(46.0 93.6)
(37.2 94.2)
(40.6 107)
2,492
340
728
498
451
475
5.35
7.83
4.80
3.86
6.16
6.31
(4.85 5.91)
(6.01 10.2)
(4.03 5.72)
(3.08 4.83)
(5.10 7.43)
(4.96 8.01)
.342
.682
.321
.301
< LOD
.426
4.40
7.16
4.02
3.44
5.00
5.49
(3.76 5.25)
(5.34 9.21)
(3.17 4.75)
(2.23 4.59)
(3.20 6.49)
(3.84 7.18)
131
100
74.9
86.8
192
102
(95.9 158)
(77.5 164)
(54.2 120)
(63.3 139)
(152 316)
(74.4 155)
2,617
352
694
631
448
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
2.51
8.24
4.93
1.55
1.75
2.66
(2.01 3.14)
(6.07 11.2)
(3.63 6.69)
(1.12 2.14)
(1.28 2.40)
(1.82 3.88)
< LOD
.539
.295
< LOD
< LOD
< LOD
2.24
8.54
4.90
1.24
1.81
1.96
(1.69 2.96)
(5.71 12.8)
(3.18 7.55)
(.818 1.88)
(1.17 2.79)
(1.00 3.82)
< LOD
.532
.292
< LOD
< LOD
< LOD
2.86
7.94
4.95
2.01
1.69
3.41
(2.22 3.68)
(5.56 11.4)
(3.71 6.60)
(1.21 3.35)
(1.02 2.80)
(1.90 6.13)
< LOD
.527
.295
< LOD
< LOD
< LOD
(.345 .845)
(.240 .365)
1.68
7.19
4.46
.843
1.01
1.95
(1.09 2.45)
(4.88 12.9)
(3.00 6.97)
(.692 1.16)
(.818 2.03)
(1.08 3.72)
52.7
102
103
33.8
27.3
35.9
(39.7 74.3)
(73.3 160)
(59.6 155)
(17.5 80.4)
(22.5 52.6)
(25.1 63.6)
1,286
231
445
281
157
172
1.33
7.44
4.55
.732
.997
1.44
(.935 2.07)
(4.18 16.7)
(2.36 10.5)
(.591 .930)
(.601 3.02)
(.646 3.16)
45.9
110
103
28.8
36.6
20.4
(34.6 74.9)
(72.7 274)
(43.8 146)
(13.4 95.5)
(16.9 156)
(12.1 159)
625
112
228
117
85
83
2.16
6.00
4.20
1.01
1.01
2.79
(1.36 3.15)
(4.39 12.1)
(2.93 6.89)
(.703 2.25)
(.870 2.39)
(1.08 7.40)
59.6
93.0
100
40.5
27.1
45.9
(41.4 96.0)
(62.8 156)
(72.2 243)
(13.8 203)
(16.3 66.5)
(23.0 803)
661
119
217
164
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
(.307 1.03)
(.208 .428)
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
(.268 .811)
(< LOD .342)
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
410
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
4.00
9.91
5.66
2.67
4.03
3.20
(3.35 4.77)
(7.22 13.6)
(4.68 6.84)
(1.93 3.69)
(3.01 5.39)
(1.86 5.51)
.249
.701
.336
< LOD
.241
.194
3.86
11.2
6.09
3.26
2.80
2.12
(3.06 4.88)
(7.16 17.6)
(4.69 7.91)
(1.91 5.56)
(1.83 4.28)
(1.13 3.98)
4.11
8.73
5.25
2.27
5.45
4.15
(3.19 5.30)
(5.75 13.3)
(4.09 6.74)
(1.36 3.79)
(3.42 8.68)
(2.06 8.34)
(.208 .295)
(.469 .983)
(.262 .519)
(< LOD .319)
(< LOD .342)
3.47
10.1
6.00
1.99
3.60
2.34
(2.48 4.61)
(7.06 15.0)
(4.57 8.05)
(1.21 3.33)
(1.85 6.21)
(1.45 4.24)
75.6
160
72.7
45.7
77.7
73.0
(60.8 97.4)
(85.0 249)
(53.8 100)
(34.3 82.1)
(58.0 133)
(30.4 296)
1,342
207
496
249
231
159
.233
.797
.324
.157
.194
.146
(.157 .322)
(.574 1.50)
(.199 .529)
(< LOD .342)
(< LOD .310)
(< LOD .217)
3.81
10.7
6.53
2.38
2.10
1.87
(2.31 4.93)
(5.44 15.8)
(4.50 9.81)
(1.20 6.28)
(1.14 5.38)
(.716 3.04)
69.7
173
81.0
62.5
46.0
28.2
(52.6 92.1)
(85.5 476)
(52.5 137)
(41.0 133)
(20.8 121)
(12.9 664)
660
99
258
116
114
73
.265
.509
.338
< LOD
.276
.334
3.28
9.53
5.33
1.83
4.28
2.59
(2.29 5.29)
(5.79 15.3)
(3.56 8.34)
(.829 4.09)
(1.91 7.76)
(1.22 6.75)
78.9
145
56.7
34.9
148
88.1
(62.4 126)
(55.0 522)
(46.9 78.1)
(21.9 122)
(74.5 835)
(36.1 366)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
(.197 .411)
(< LOD .461)
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
5.07
6.72
5.92
4.25
4.89
5.57
(4.68 5.49)
(4.52 9.99)
(4.64 7.57)
(3.40 5.30)
(4.13 5.79)
(4.72 6.57)
.347
.515
.342
.321
< LOD
.417
(.312 .382)
(< LOD .823)
(.259 .492)
(< LOD .376)
(< LOD .498)
4.30
5.35
4.83
3.90
3.75
4.76
(3.85 4.69)
(3.55 8.26)
(3.42 8.22)
(3.10 4.89)
(3.03 4.81)
(3.87 6.27)
100
126
91.6
86.6
160
78.8
(86.1 136)
(75.5 219)
(59.4 149)
(67.4 129)
(88.4 194)
(65.6 120)
2,100
193
378
488
447
594
4.08
5.60
6.94
3.54
3.42
4.27
(3.45 4.83)
(3.23 9.71)
(4.98 9.67)
(2.51 5.00)
(2.66 4.40)
(3.25 5.62)
.304
.403
.311
.257
.278
.354
(.237 .370)
(< LOD .810)
(.186 .652)
(< LOD .350)
(.191 .389)
(< LOD .493)
3.57
4.09
6.78
3.16
2.96
3.86
(2.90 4.35)
(2.17 8.47)
(3.52 13.0)
(2.22 4.91)
(2.16 3.95)
(2.76 5.25)
73.4
109
103
69.1
55.5
60.7
(58.4 88.8)
(43.9 358)
(58.5 260)
(48.0 95.7)
(36.3 150)
(37.5 117)
1,034
99
191
217
229
298
6.27
8.31
4.99
5.12
7.01
6.86
(5.53 7.11)
(5.47 12.6)
(3.73 6.67)
(3.67 7.15)
(5.37 9.15)
(5.44 8.66)
.400
.803
.347
.359
< LOD
.484
5.31
6.95
4.27
4.61
5.48
5.96
(4.37 6.35)
(4.34 11.5)
(3.11 5.86)
(3.37 6.48)
(3.20 7.60)
(4.28 7.84)
141
132
74.7
103
194
104
(108 183)
(75.9 259)
(47.4 131)
(66.8 197)
(157 323)
(73.9 167)
1,066
94
187
271
218
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
411
4.03
3.83
4.58
4.59
(2.97 5.45)
(3.32 4.42)
(4.19 5.01)
(4.04 5.21)
<LOD
<LOD
<LOD
<LOD
4.44
3.23
4.09
3.66
(3.11 6.27)
(2.56 4.12)
(3.55 4.58)
(3.12 4.41)
165
281
201
211
(143 220)
(157 433)
(185 271)
(182 326)
2,271
2,794
2,581
2,528
6.00
7.03
6.73
7.93
(4.04 8.91)
(5.05 9.77)
(4.55 9.97)
(5.73 11.0)
<LOD
<LOD
.389
<LOD
7.13
6.47
5.92
7.15
(4.26 16.0)
(4.28 11.4)
(4.10 8.22)
(3.86 11.3)
172
302
146
340
(98.0 264)
(155 468)
(88.9 382)
(253 495)
287
396
341
351
4.13
4.57
4.76
6.30
(2.33 7.35)
(3.44 6.07)
(3.71 6.11)
(4.89 8.13)
<LOD
<LOD
<LOD
.274
5.68
3.86
4.25
5.67
(2.94 11.0)
(2.87 5.32)
(3.22 6.13)
(3.60 8.37)
117
249
182
251
(77.3 337)
(134 331)
(119 269)
(127 705)
667
744
729
693
3.18
2.72
3.55
3.47
(2.13 4.76)
(2.10 3.51)
(2.86 4.40)
(2.84 4.25)
<LOD
<LOD
<LOD
<LOD
3.53
2.06
2.98
3.22
(2.09 5.26)
(1.55 2.97)
(2.24 3.75)
(2.11 4.37)
226
152
214
166
(165 272)
(99.5 442)
(114 434)
(136 207)
481
604
546
583
4.26
5.04
4.93
4.09
(3.27 5.56)
(3.50 7.26)
(4.19 5.80)
(3.19 5.24)
<LOD
<LOD
<LOD
<LOD
3.57
4.39
4.29
3.01
(2.42 6.26)
(2.65 7.23)
(3.06 6.30)
(2.16 4.19)
156
473
227
259
(133 261)
(212 885)
(190 612)
(189 800)
365
531
450
449
4.66
2.75
4.93
5.42
(3.13 6.94)
(2.14 3.52)
(3.88 6.28)
(4.19 7.02)
<LOD
<LOD
<LOD
<LOD
6.37
1.86
4.37
4.31
(3.15 11.3)
(1.30 2.79)
(3.20 6.17)
(2.90 7.08)
104
150
239
244
(81.6 172)
(78.7 449)
(136 418)
(111 754)
471
519
515
452
3.95
3.10
3.83
3.97
(2.79 5.58)
(2.48 3.86)
(3.10 4.73)
(3.33 4.72)
<LOD
<LOD
<LOD
<LOD
4.50
2.87
3.33
3.48
(2.96 6.47)
(2.00 3.89)
(2.45 4.35)
(2.75 4.33)
209
152
193
165
(130 265)
(101 334)
(128 255)
(144 230)
1,087
1,375
1,240
1,252
4.10
4.68
5.45
5.27
(3.00 5.60)
(3.87 5.68)
(4.71 6.30)
(4.56 6.09)
<LOD
<LOD
<LOD
<LOD
4.17
3.74
4.81
3.98
(3.10 6.33)
(2.78 4.87)
(4.08 5.89)
(3.07 5.49)
155
398
243
323
(119 341)
(199 741)
(194 318)
(201 683)
1,184
1,419
1,341
1,276
2.19
2.30
2.30
2.75
(1.49 3.24)
(1.48 3.57)
(1.68 3.15)
(1.92 3.93)
<LOD
<LOD
<LOD
<LOD
1.87
1.45
1.65
1.68
(1.16 3.04)
(.769 3.15)
(.847 3.02)
(1.06 2.91)
135
107
125
134
(96.7 290)
(59.9 303)
(89.4 171)
(74.9 204)
721
679
652
634
3.65
3.75
3.90
4.09
(2.92 4.57)
(2.75 5.11)
(3.02 5.04)
(3.13 5.34)
<LOD
<LOD
<LOD
<LOD
5.21
3.54
3.13
4.20
(3.70 6.74)
(2.13 5.48)
(1.94 5.59)
(2.48 5.69)
117
217
146
207
(83.6 283)
(102 371)
(127 231)
(113 454)
527
692
680
662
4.48
4.08
5.18
4.96
(3.11 6.47)
(3.41 4.88)
(4.71 5.70)
(4.33 5.69)
<LOD
<LOD
<LOD
<LOD
4.72
3.51
4.58
3.96
(2.91 7.48)
(2.46 4.57)
(4.15 5.31)
(3.28 4.67)
178
300
225
227
(148 227)
(158 505)
(189 308)
(184 333)
810
1,211
1,061
1,039
Age group
611 years
19992000
20012002
20032004
20052006
(<LOD .743)
1219 years
19992000
20012002
20032004
20052006
(<LOD .304)
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
412
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
800
95th Percentile
600
400
j
j
j
200
j
j
j
j
j
j
j
j
j
j
0
20
50th Percentile
15
10
j
j
j
j
j
j
j
j
j
j
j
j
j
j
j
j
j
j
j
j
j
0
1000
600
400
200
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
800
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
413
414
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
35.6
37.4
38.7
(31.2 40.5)
(33.8 41.3)
(34.9 42.8)
(35.9 44.7)
(33.7 41.1)
(32.2 43.3)
(38.3 46.1)
(34.7 44.2)
(31.3 44.1)
(34.3 43.2)
(35.8 41.6)
.899
1.02
.640
.697
.813
2.24
2.23
.763
< LOD
.478
.745
(.856 4.39)
(.927 3.06)
(.392 1.50)
(.399 1.29)
2.41
2.90
2.44
2.49
2.44
5.43
5.16
2.70
1.72
2.42
2.48
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
40.1
37.2
37.4
42.0
39.2
37.2
38.5
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
38.6
(1.70 2.94)
(2.15 3.51)
(1.49 3.41)
(1.47 3.72)
(1.59 3.02)
(2.74 6.96)
(2.97 6.05)
(1.49 3.87)
(.528 2.44)
(1.28 3.37)
(1.79 3.01)
39.9
43.1
44.2
45.9
42.3
40.2
44.2
43.7
44.8
44.9
43.9
(35.5 44.6)
(38.4 47.4)
(40.2 49.6)
(41.2 49.2)
(39.6 45.9)
(35.8 45.4)
(39.5 50.3)
(39.7 49.9)
(37.6 51.6)
(38.9 52.6)
(41.1 47.2)
359
275
367
382
356
265
295
365
423
362
377
(287 434)
(249 348)
(310 423)
(308 453)
(307 446)
(199 357)
(267 354)
(314 494)
(330 512)
(301 475)
(335 414)
457
438
575
585
561
387
462
651
658
620
579
(392 890)
(372 517)
(480 701)
(457 1,080)
(464 712)
(335 558)
(374 656)
(493 1,350)
(462 1,250)
(442 1,140)
(496 683)
1,287
1,343
2,108
2,496
2,626
692
1,422
1,137
901
970
5,122
Geometric mean and selected percentiles of urine concentrations (in g/L) for the total U.S. population aged 6 years and older, National Health and
Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
60
20
40
Females
Males
Urinary enterodiol
(g/L)
80
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
60
40
20
0
Urinary enterodiol
(g/L)
80
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
60
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary enterodiol
(g/L)
80
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
415
38.6
37.4
42.0
39.2
37.2
38.5
(35.8 41.6)
(32.2 43.3)
(38.3 46.1)
(34.7 44.2)
(31.3 44.1)
(34.3 43.2)
5.86
8.10
8.12
5.37
3.96
5.80
(4.78 6.69)
(6.48 9.64)
(6.76 9.75)
(4.41 6.89)
(2.46 6.11)
(3.81 6.96)
43.9
40.2
44.2
43.7
44.8
44.9
(41.1 47.2)
(35.8 45.4)
(39.5 50.3)
(39.7 49.9)
(37.6 51.6)
(38.9 52.6)
243
150
192
237
266
256
(231 260)
(126 204)
(168 229)
(216 267)
(250 284)
(219 280)
5,122
692
1,422
1,137
901
970
40.1
38.4
42.6
38.9
40.8
40.1
(35.9 44.7)
(31.1 47.5)
(37.3 48.7)
(31.6 47.9)
(32.8 50.7)
(33.1 48.7)
6.59
8.71
8.25
5.61
5.03
6.13
(5.15 7.44)
(5.91 13.1)
(6.58 10.2)
(3.56 7.73)
(2.54 8.69)
(4.41 7.48)
45.9
39.7
48.4
43.8
47.7
50.2
(41.2 49.2)
(34.8 47.9)
(38.5 56.4)
(36.7 50.8)
(38.3 54.0)
(41.1 56.3)
255
144
196
236
279
256
(228 269)
(119 267)
(170 250)
(202 293)
(261 332)
(210 307)
2,496
340
728
499
451
478
37.2
36.3
41.4
39.4
34.1
37.3
(33.7 41.1)
(30.5 43.1)
(36.8 46.6)
(34.2 45.5)
(27.1 42.9)
(31.9 43.6)
5.09
7.66
8.00
4.90
3.31
4.59
(4.12 6.40)
(5.98 9.58)
(5.89 10.0)
(4.25 6.75)
(1.49 5.80)
(2.99 6.98)
42.3
40.7
41.9
43.7
41.6
42.3
(39.6 45.9)
(32.9 49.6)
(37.7 46.4)
(39.8 53.3)
(34.4 51.5)
(33.7 51.7)
237
157
181
243
244
255
(211 262)
(120 220)
(155 221)
(209 301)
(205 278)
(204 302)
2,626
352
694
638
450
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
35.6
27.4
35.6
38.2
39.5
28.4
(31.2 40.5)
(21.8 34.5)
(30.9 41.1)
(29.5 49.6)
(28.6 54.5)
(22.0 36.8)
4.89
2.79
5.80
5.52
5.19
3.31
(4.22 5.85)
(1.96 5.28)
(3.99 8.54)
(3.85 7.09)
(1.73 11.5)
(1.54 5.74)
39.9
33.0
42.0
41.8
41.1
35.1
(35.5 44.6)
(24.6 40.2)
(34.8 48.2)
(31.6 52.4)
(31.9 53.6)
(22.0 49.2)
227
166
178
245
272
165
34.9
28.1
34.5
33.4
42.7
40.6
(28.8 42.2)
(19.2 40.9)
(26.5 45.0)
(22.2 50.1)
(28.2 64.6)
(25.5 64.6)
36.3
26.7
36.9
44.9
36.3
21.3
(32.0 41.2)
(20.1 35.4)
(32.0 42.4)
(32.5 62.1)
(22.5 58.5)
(15.0 30.3)
(182 294)
(130 245)
(141 203)
(183 438)
(192 385)
(111 340)
1,287
231
445
282
157
172
4.34
2.97
4.74
4.48
4.04
4.67
(3.14 6.04)
(.785 7.94)
(2.34 9.50)
(.741 7.36)
(< LOD 14.4)
(2.24 6.33)
43.3
34.7
41.5
42.6
51.2
42.7
(35.6 49.9)
(22.8 48.2)
(30.3 52.8)
(24.6 55.0)
(32.8 64.8)
(19.6 89.1)
206
135
189
204
256
222
(165 288)
(92.4 185)
(126 266)
(135 414)
(170 404)
(160 2,850)
625
112
228
117
85
83
5.48
2.49
7.51
6.26
5.97
2.49
(4.68 6.52)
(1.71 4.92)
(5.16 9.36)
(3.86 9.31)
(< LOD 11.6)
(.826 4.86)
37.1
30.5
42.2
41.4
31.7
28.1
(31.4 42.1)
(20.3 43.1)
(35.0 53.7)
(27.8 61.5)
(19.0 59.2)
(16.1 45.6)
238
196
162
306
274
115
(185 325)
(136 335)
(118 195)
(193 937)
(189 476)
(67.5 254)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
416
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
37.4
39.0
40.4
34.4
38.3
38.6
(33.8 41.3)
(32.6 46.6)
(35.8 45.5)
(28.9 40.8)
(31.0 47.3)
(29.7 50.2)
6.94
8.75
7.82
4.70
6.45
5.01
(5.78 8.13)
(7.57 10.9)
(6.32 10.2)
(2.73 9.26)
(3.55 9.50)
(2.37 11.3)
43.1
38.5
45.9
43.1
42.9
41.5
(38.4 47.4)
(32.6 47.4)
(40.2 53.4)
(30.9 49.3)
(34.8 56.0)
(33.1 54.2)
202
144
203
182
229
213
(164 241)
(113 222)
(158 252)
(138 247)
(159 306)
(143 308)
1,343
207
496
249
231
160
35.8
36.7
41.5
34.8
34.2
33.8
(31.0 41.4)
(30.6 44.0)
(35.7 48.2)
(25.0 48.5)
(25.5 45.8)
(22.6 50.5)
7.23
8.71
8.60
9.49
6.41
3.16
(5.38 9.93)
(5.22 12.3)
(6.42 10.6)
(1.28 12.7)
(.424 11.2)
(< LOD 9.91)
41.2
37.6
46.0
42.3
40.1
38.8
(37.1 44.8)
(32.5 45.6)
(36.3 56.7)
(28.4 49.0)
(31.0 51.0)
(22.4 60.4)
199
130
220
194
181
235
(145 256)
(93.9 271)
(161 274)
(117 649)
(103 339)
(178 506)
661
99
258
116
114
74
38.8
41.5
39.3
34.0
42.1
42.0
(33.8 44.5)
(28.5 60.3)
(34.1 45.3)
(25.1 45.9)
(31.0 57.1)
(31.7 55.6)
6.71
8.80
7.36
4.44
6.38
8.15
(4.70 8.09)
(5.57 12.1)
(4.62 10.8)
(1.93 7.72)
(3.20 9.27)
(2.80 14.6)
45.3
38.5
45.8
43.6
47.1
44.5
(36.5 52.9)
(25.1 63.3)
(38.4 54.9)
(29.2 57.8)
(30.4 65.8)
(31.8 61.6)
209
162
181
163
241
173
(159 246)
(105 734)
(148 227)
(129 250)
(167 440)
(120 404)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
38.7
39.3
42.1
40.0
36.3
38.8
(34.9 42.8)
(30.9 50.1)
(36.3 48.8)
(33.4 47.9)
(29.2 45.1)
(34.2 43.9)
5.87
8.74
8.80
5.42
3.71
5.91
(4.61 6.90)
(6.52 13.2)
(6.91 10.6)
(4.12 7.14)
(2.29 6.10)
(3.70 7.29)
44.2
40.4
42.8
43.8
45.2
46.0
(40.2 49.6)
(34.8 48.0)
(36.5 54.4)
(36.4 55.7)
(35.6 54.8)
(38.9 56.1)
244
139
176
238
264
258
(228 264)
(115 232)
(154 230)
(207 296)
(243 281)
(213 280)
2,108
193
378
494
448
595
41.1
40.8
42.5
40.6
42.2
39.4
(35.5 47.6)
(29.6 56.1)
(35.6 50.7)
(30.3 54.3)
(31.6 56.5)
(31.3 49.4)
6.75
9.08
9.11
5.50
5.30
6.58
(5.23 8.72)
(4.58 17.3)
(6.18 11.8)
(3.34 9.65)
(2.37 10.1)
(4.37 8.47)
46.4
39.9
48.2
43.8
48.1
50.3
(40.6 52.7)
(32.8 49.3)
(36.1 57.6)
(33.6 59.1)
(36.7 58.2)
(40.5 56.9)
259
129
176
238
280
246
(222 275)
(109 356)
(148 252)
(184 394)
(259 415)
(182 286)
1,035
99
191
217
229
299
36.4
37.7
41.6
39.4
31.2
38.3
(31.6 41.9)
(28.8 49.2)
(33.6 51.6)
(31.4 49.4)
(23.5 41.4)
(32.0 45.8)
4.79
7.98
8.15
4.87
2.52
4.66
(3.03 6.57)
(2.17 11.7)
(5.01 13.4)
(3.72 7.60)
(.780 5.15)
(2.91 7.14)
42.3
41.0
40.1
46.0
40.5
44.6
(38.0 49.9)
(29.3 54.4)
(34.9 51.0)
(34.2 56.9)
(31.0 55.4)
(33.4 58.2)
240
155
174
236
242
263
(201 273)
(94.9 369)
(131 278)
(183 332)
(189 276)
(207 309)
1,073
94
187
277
219
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
417
26.6
35.7
39.5
37.7
(21.9 32.3)
(32.5 39.3)
(36.1 43.3)
(33.2 42.9)
< LOD
2.10
2.45
2.47
33.9
39.3
44.8
42.4
(29.5 38.7)
(36.4 43.1)
(40.7 50.3)
(39.3 47.2)
263
253
367
378
(219 338)
(225 307)
(318 424)
(316 447)
2,527
2,794
2,594
2,528
26.5
33.6
42.0
33.2
(17.1 41.0)
(29.8 37.8)
(34.5 51.1)
(26.1 42.3)
< LOD
3.40
6.62
2.86
(1.90 5.06)
(2.92 8.30)
(1.71 6.66)
29.3
35.5
42.0
38.5
(21.2 43.4)
(29.4 43.5)
(34.6 49.1)
(34.7 44.3)
272
202
311
178
(203 477)
(170 333)
(230 523)
(136 377)
327
396
341
351
29.8
35.3
45.1
39.1
(23.8 37.2)
(30.5 40.9)
(39.4 51.6)
(34.0 45.0)
< LOD
3.30
5.28
4.19
(2.02 5.23)
(3.63 6.65)
(1.72 6.24)
34.0
37.6
46.2
41.0
(27.8 42.0)
(34.8 42.9)
(38.8 56.8)
(36.8 46.4)
252
235
324
264
(193 357)
(172 344)
(276 416)
(232 367)
744
744
729
693
27.4
35.3
39.7
38.6
(22.1 34.1)
(29.5 42.3)
(33.2 47.5)
(32.3 46.2)
< LOD
< LOD
2.69
3.01
(1.32 3.59)
(1.16 4.28)
36.0
42.5
44.5
43.5
(29.9 41.3)
(36.6 47.6)
(37.7 53.9)
(34.5 53.8)
230
244
372
352
(177 401)
(213 371)
(308 654)
(289 519)
535
604
554
583
26.1
37.3
35.3
39.0
(21.4 31.8)
(29.2 47.7)
(28.6 43.6)
(29.4 51.8)
< LOD
< LOD
1.36
2.30
34.6
40.5
42.6
45.9
(28.9 41.2)
(34.5 50.9)
(36.3 50.6)
(34.1 59.0)
280
289
418
445
(249 406)
(232 488)
(283 712)
(287 651)
414
531
452
449
23.7
35.4
41.7
35.6
(18.8 30.0)
(30.0 41.8)
(36.7 47.4)
(29.0 43.8)
< LOD
2.87
2.84
1.66
(1.55 4.49)
(1.82 4.35)
(< LOD 3.05)
29.7
36.5
50.8
39.9
(21.9 37.4)
(30.2 46.0)
(43.2 58.3)
(31.1 51.8)
264
224
309
415
(167 479)
(195 364)
(265 615)
(322 614)
507
519
518
452
25.3
35.2
39.7
40.4
(19.5 32.7)
(31.8 39.1)
(36.2 43.6)
(32.8 49.8)
< LOD
< LOD
2.43
2.64
(.998 3.97)
(.957 4.13)
33.0
40.4
45.1
46.1
(28.0 37.9)
(36.8 44.2)
(40.6 50.6)
(39.1 52.0)
258
263
360
413
(179 324)
(225 351)
(275 515)
(291 544)
1,206
1,375
1,244
1,252
27.9
36.2
39.3
35.4
(23.4 33.3)
(32.2 40.7)
(33.8 45.5)
(30.3 41.2)
< LOD
3.20
2.60
2.43
36.0
38.5
44.8
41.0
(29.9 40.2)
(35.3 43.4)
(38.5 52.7)
(35.7 45.3)
280
246
396
338
(228 397)
(222 286)
(313 485)
(272 477)
1,321
1,419
1,350
1,276
21.7
30.5
33.1
38.1
(19.5 24.1)
(25.7 36.3)
(26.4 41.6)
(32.2 45.1)
< LOD
1.62
1.90
2.60
27.9
33.8
38.5
40.5
(24.6 34.6)
(29.0 39.1)
(31.7 47.1)
(35.4 47.5)
212
240
298
382
(171 258)
(198 304)
(201 4,230)
(295 514)
791
679
653
634
25.7
35.1
40.3
34.7
(21.5 30.6)
(28.8 42.8)
(34.7 46.8)
(30.1 40.1)
< LOD
2.08
3.23
2.73
31.2
38.8
47.2
38.4
(24.4 35.9)
(33.3 49.8)
(40.7 54.4)
(33.3 45.1)
266
222
284
268
(219 356)
(178 386)
(244 442)
(248 382)
597
692
681
662
29.1
35.6
40.1
37.3
(24.2 35.1)
(31.8 40.0)
(35.6 45.1)
(31.2 44.6)
< LOD
1.82
2.64
2.36
37.5
40.4
45.9
42.6
(31.6 43.7)
(36.5 44.7)
(38.9 55.3)
(37.1 49.6)
271
254
368
366
(219 401)
(219 341)
(305 441)
(286 456)
899
1,211
1,069
1,039
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
418
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
5000
95th Percentile
4000
3000
2000
1000
0
60
50th Percentile
50
j
j
j
40
j
j
30
20
10
6
j
j
4
j
j
j
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
419
420
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
32.1
26.3
39.4
(27.9 36.9)
(23.5 29.3)
(35.5 43.6)
(28.5 35.5)
(38.9 46.4)
(35.1 46.7)
(28.7 34.1)
(29.3 38.1)
(31.8 44.5)
(39.9 50.9)
(34.3 39.7)
1.20
.859
.849
.588
.975
3.41
1.87
.793
< LOD
.610
.909
(1.25 4.93)
(.883 2.78)
(.250 1.49)
(.427 1.35)
2.67
2.60
2.87
2.25
2.95
6.16
3.58
2.29
1.75
4.15
2.69
(1.62 3.47)
(1.56 3.18)
(1.86 4.12)
(1.31 3.67)
(2.22 4.19)
(3.95 7.30)
(2.79 4.68)
(1.52 2.99)
(.889 3.41)
(1.05 5.93)
(1.93 3.70)
35.1
27.8
45.4
34.6
48.4
43.6
33.6
34.9
42.7
51.0
41.1
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
31.8
42.5
40.5
31.3
33.4
37.6
45.1
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
36.9
(30.5 39.3)
(24.9 31.4)
(40.8 49.6)
(32.0 38.0)
(45.0 54.6)
(38.1 48.1)
(31.9 36.1)
(31.6 43.0)
(36.6 50.2)
(47.1 55.6)
(38.2 44.1)
305
196
315
280
375
216
186
301
376
386
309
(239 375)
(165 218)
(287 375)
(233 338)
(296 432)
(198 311)
(163 232)
(244 400)
(286 491)
(290 539)
(283 360)
431
276
508
445
563
367
278
492
686
556
501
(337 876)
(224 353)
(438 736)
(331 789)
(445 852)
(267 589)
(220 542)
(366 808)
(438 1,530)
(469 1,500)
(440 716)
1,287
1,343
2,108
2,496
2,626
692
1,422
1,137
901
970
5,122
Geometric mean and selected percentiles of urine concentrations (in g/g creatinine) for the total U.S. population aged 6 years and older, National
Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
60
20
40
Females
Males
Urinary enterodiol
(g/g creatinine)
80
Overall
611
1219
2039
4059
60+
611
NonHispanic Blacks
1219
2039
4059
60+
60
40
20
0
Urinary enterodiol
(g/g creatinine)
80
NonHispanic Whites
611
1219
2039
4059
60+
611
1219
4059
60+
Males
60
20
40
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary enterodiol
(g/g creatinine)
80
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
421
36.9
40.5
31.3
33.4
37.6
45.1
(34.3 39.7)
(35.1 46.7)
(28.7 34.1)
(29.3 38.1)
(31.8 44.5)
(39.9 50.9)
6.26
8.85
6.90
5.04
5.64
7.91
(5.53 7.25)
(6.90 12.2)
(5.55 8.00)
(4.01 6.33)
(3.76 7.61)
(6.45 9.98)
41.1
43.6
33.6
34.9
42.7
51.0
(38.2 44.1)
(38.1 48.1)
(31.9 36.1)
(31.6 43.0)
(36.6 50.2)
(47.1 55.6)
202
166
130
185
217
228
(185 213)
(134 201)
(117 154)
(156 230)
(201 275)
(198 290)
5,122
692
1,422
1,137
901
970
31.8
38.5
28.9
28.3
32.3
36.9
(28.5 35.5)
(31.7 46.9)
(25.7 32.5)
(23.0 34.9)
(25.6 40.8)
(30.3 45.1)
5.68
8.54
5.59
4.69
5.53
6.29
(4.73 6.43)
(6.17 13.0)
(5.19 7.40)
(3.28 5.94)
(3.19 7.12)
(4.32 8.00)
34.6
38.3
32.6
29.9
33.7
43.8
(32.0 38.0)
(33.3 46.1)
(28.5 34.9)
(25.6 35.5)
(28.4 43.1)
(38.4 51.5)
176
144
123
152
207
204
(150 210)
(117 205)
(113 134)
(128 253)
(158 305)
(169 240)
2,496
340
728
499
451
478
42.5
42.7
34.1
39.2
43.4
52.8
(38.9 46.4)
(35.9 50.8)
(30.1 38.5)
(33.9 45.5)
(35.2 53.6)
(46.0 60.6)
7.53
9.12
8.29
5.48
5.72
9.89
(5.73 8.57)
(6.71 12.6)
(4.44 9.54)
(3.87 7.78)
(2.41 9.51)
(7.70 11.6)
48.4
48.1
36.0
46.3
52.6
57.4
(45.0 54.6)
(40.3 57.8)
(32.2 39.7)
(35.7 57.4)
(42.7 63.1)
(50.4 65.3)
210
177
144
203
231
249
(198 234)
(140 218)
(119 165)
(165 243)
(207 301)
(201 407)
2,626
352
694
638
450
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
32.1
34.4
27.5
30.9
36.1
35.1
(27.9 36.9)
(27.9 42.4)
(23.8 31.9)
(23.4 40.7)
(27.6 47.3)
(29.0 42.6)
4.54
5.18
4.55
4.02
5.14
5.53
(3.80 6.35)
(3.71 6.71)
(3.18 7.34)
(2.24 6.39)
(2.37 11.4)
(5.00 7.33)
35.1
37.2
33.6
31.1
35.2
40.9
(30.5 39.3)
(33.9 44.9)
(28.0 37.6)
(27.4 39.6)
(27.5 43.1)
(32.0 50.3)
185
178
123
203
234
171
(145 226)
(135 226)
(96.1 147)
(126 343)
(172 328)
(127 206)
27.6
33.6
25.0
24.2
31.3
36.1
(22.7 33.4)
(24.5 46.3)
(19.6 31.9)
(16.6 35.3)
(21.1 46.5)
(23.6 55.3)
37.9
35.2
30.4
41.1
42.2
34.4
(33.8 42.5)
(26.6 46.6)
(26.0 35.7)
(30.3 55.6)
(28.5 62.7)
(25.4 46.4)
1,287
231
445
282
157
172
3.88
5.54
3.94
3.11
4.37
5.32
(2.69 5.22)
(1.57 10.7)
(1.46 7.15)
(.554 5.48)
(< LOD 9.03)
(1.31 7.57)
33.1
39.3
31.8
27.9
36.9
42.1
(27.7 39.2)
(30.6 49.5)
(22.5 38.9)
(20.7 38.8)
(24.4 56.4)
(24.2 74.3)
145
136
128
126
151
180
(125 188)
(109 223)
(88.0 179)
(93.7 316)
(125 326)
(111 3,470)
625
112
228
117
85
83
6.60
5.04
6.37
6.65
10.9
7.20
(4.51 9.67)
(3.18 6.59)
(3.16 9.37)
(2.66 10.7)
(< LOD 15.6)
(1.42 12.2)
35.9
36.4
36.5
34.6
34.7
39.5
(33.1 40.5)
(28.5 45.9)
(29.2 40.5)
(28.4 43.7)
(24.5 42.5)
(30.7 49.7)
214
189
111
225
322
134
(182 310)
(140 434)
(87.0 153)
(156 1,900)
(224 401)
(114 219)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
422
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
26.3
36.6
23.2
21.3
27.8
34.4
(23.5 29.3)
(30.6 43.8)
(20.8 25.8)
(17.7 25.7)
(22.9 33.9)
(27.2 43.5)
5.31
9.75
4.63
3.72
4.81
6.11
(4.24 6.34)
(7.92 11.3)
(3.25 5.70)
(2.11 6.01)
(3.72 6.10)
(3.63 7.83)
27.8
34.5
26.0
23.0
31.2
40.0
(24.9 31.4)
(25.8 45.8)
(23.5 29.3)
(17.8 28.7)
(25.2 42.5)
(25.1 53.3)
125
136
97.7
114
138
158
(110 152)
(108 215)
(86.3 107)
(101 145)
(98.2 207)
(126 211)
1,343
207
496
249
231
160
20.9
34.7
22.2
16.7
19.5
24.8
(17.8 24.6)
(28.7 41.9)
(19.3 25.5)
(12.1 23.1)
(14.7 25.9)
(17.4 35.3)
4.17
9.17
3.94
3.28
3.83
2.85
(3.10 5.70)
(6.49 13.8)
(2.80 5.30)
(.958 7.92)
(.303 5.78)
(< LOD 5.98)
23.1
27.8
25.8
15.6
24.4
29.4
(21.0 25.9)
(23.6 42.1)
(22.0 30.4)
(13.4 23.1)
(19.1 30.5)
(16.7 46.4)
103
133
98.2
98.0
88.7
154
(84.9 141)
(87.7 254)
(78.0 114)
(48.0 228)
(62.6 143)
(105 375)
661
99
258
116
114
74
31.8
38.7
24.3
25.8
37.3
42.4
(27.2 37.1)
(26.3 56.9)
(21.1 27.9)
(18.5 36.1)
(27.8 50.0)
(32.8 54.7)
6.96
9.48
5.67
4.01
7.65
7.78
(4.95 7.88)
(5.62 11.4)
(2.69 8.07)
(1.38 6.49)
(4.05 10.2)
(3.31 15.1)
34.8
36.2
26.0
28.5
45.8
42.5
(28.3 44.5)
(23.8 63.6)
(22.5 31.5)
(21.8 40.2)
(26.5 61.7)
(29.1 68.6)
145
138
97.2
122
186
157
(124 183)
(104 671)
(83.9 118)
(104 202)
(131 262)
(127 219)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
39.4
42.6
33.0
36.9
39.0
46.2
(35.5 43.6)
(34.0 53.4)
(28.8 37.8)
(30.1 45.0)
(31.5 48.3)
(40.4 52.9)
6.60
11.1
7.53
5.49
5.69
8.98
(5.58 8.19)
(5.34 16.8)
(5.66 9.35)
(3.01 7.72)
(3.16 8.27)
(6.44 11.1)
45.4
46.1
34.6
42.6
46.7
52.2
(40.8 49.6)
(37.0 52.0)
(31.7 40.5)
(32.9 54.0)
(37.1 56.0)
(47.7 56.5)
205
151
132
187
217
234
(186 224)
(121 226)
(117 163)
(154 248)
(195 290)
(199 291)
2,108
193
378
494
448
595
34.4
39.5
30.3
32.2
35.4
36.7
(29.6 40.0)
(29.3 53.4)
(26.1 35.3)
(23.7 43.7)
(26.0 48.1)
(29.0 46.4)
6.14
12.2
6.16
5.54
5.70
6.56
(4.80 7.62)
(1.42 18.9)
(5.29 8.96)
(2.27 8.17)
(2.28 9.38)
(2.03 10.7)
37.5
38.4
33.2
32.5
37.4
44.0
(32.7 42.5)
(31.5 49.8)
(27.5 40.5)
(23.0 47.3)
(28.6 50.0)
(38.4 52.2)
186
127
123
185
213
195
(150 238)
(93.3 328)
(111 139)
(128 338)
(158 341)
(164 241)
1,035
99
191
217
229
299
44.9
46.6
36.2
42.2
43.1
55.5
(39.5 51.0)
(36.2 60.0)
(29.2 44.9)
(33.9 52.5)
(32.8 56.7)
(48.1 64.0)
7.63
10.2
8.91
4.89
5.49
10.2
(5.36 9.36)
(4.05 15.4)
(4.19 10.9)
(2.69 8.91)
(1.59 9.39)
(7.90 12.2)
55.6
53.8
39.1
56.3
58.2
60.5
(47.8 60.8)
(41.4 64.6)
(31.4 46.2)
(40.0 66.8)
(42.5 71.1)
(51.3 67.3)
216
171
151
203
217
291
(199 251)
(131 302)
(117 216)
(159 275)
(204 305)
(203 469)
1,073
94
187
277
219
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
423
24.2
33.5
37.0
36.8
(20.3 28.9)
(30.7 36.7)
(33.6 40.7)
(32.7 41.4)
<LOD
2.54
2.45
2.95
(<LOD 2.96)
(1.86 3.57)
(1.16 4.43)
29.9
37.6
41.7
40.9
(25.1 34.7)
(33.0 42.0)
(38.0 45.4)
(36.0 46.1)
239
224
293
323
(203 320)
(201 249)
(249 376)
(283 421)
2,527
2,794
2,594
2,528
27.0
38.1
44.7
36.6
(18.6 39.3)
(32.5 44.7)
(37.4 53.5)
(28.9 46.4)
<LOD
3.88
6.38
4.69
(2.45 5.14)
(3.61 8.72)
(1.80 7.52)
33.5
39.3
46.5
37.8
(22.1 43.6)
(31.0 53.1)
(38.6 58.0)
(33.0 46.5)
278
303
213
221
(199 534)
(244 390)
(184 414)
(186 349)
327
396
341
351
20.1
27.2
33.8
29.0
(16.7 24.2)
(23.3 31.8)
(30.3 37.7)
(25.2 33.3)
<LOD
2.75
4.69
3.01
(1.30 4.91)
(2.38 5.62)
(2.13 3.60)
24.0
28.7
34.7
31.1
(19.9 30.1)
(25.0 34.8)
(33.3 38.2)
(28.0 36.1)
157
150
216
165
(125 176)
(116 316)
(155 344)
(160 214)
744
744
729
693
21.7
28.5
33.5
33.3
(17.1 27.6)
(23.7 34.3)
(27.4 40.9)
(27.5 40.3)
<LOD
<LOD
2.26
2.39
(1.63 2.71)
(.618 4.04)
26.4
30.2
33.8
36.2
(21.4 32.4)
(25.2 39.4)
(27.9 46.2)
(30.4 47.2)
232
187
299
318
(149 371)
(156 277)
(245 425)
(207 523)
535
604
554
583
26.4
37.1
33.8
41.6
(21.9 31.9)
(30.0 45.7)
(27.6 41.5)
(31.7 54.5)
<LOD
<LOD
1.16
2.95
(<LOD 2.44)
(<LOD 5.29)
31.8
44.2
40.8
46.6
(27.4 38.7)
(37.7 51.2)
(33.6 47.8)
(34.2 61.6)
293
246
369
375
(217 358)
(180 305)
(241 719)
(276 802)
414
531
452
449
28.6
41.9
49.4
41.3
(23.0 35.6)
(35.8 49.2)
(42.8 57.0)
(33.4 51.1)
<LOD
3.67
5.75
2.15
(2.14 6.71)
(1.73 6.45)
(<LOD 5.47)
33.5
46.3
57.1
45.4
(29.2 43.9)
(41.8 50.8)
(51.9 63.1)
(38.7 52.1)
258
238
309
418
(186 430)
(220 360)
(230 697)
(290 798)
507
519
518
452
19.8
28.7
31.1
32.5
(15.4 25.4)
(26.0 31.7)
(27.5 35.0)
(26.7 39.5)
<LOD
<LOD
2.03
2.46
(1.17 3.66)
(.565 4.41)
25.3
31.4
34.8
34.2
(20.6 31.1)
(27.0 36.7)
(32.2 38.4)
(29.5 41.0)
198
212
249
310
(153 287)
(184 259)
(195 368)
(229 493)
1,206
1,375
1,244
1,252
29.3
38.9
43.6
41.4
(25.0 34.4)
(34.9 43.3)
(38.3 49.7)
(36.1 47.4)
<LOD
3.35
2.76
3.10
(<LOD 4.62)
(2.24 4.15)
(.952 5.10)
35.3
43.8
49.0
48.2
(29.6 41.6)
(39.3 48.7)
(43.4 57.7)
(41.8 55.7)
320
234
375
372
(233 370)
(185 305)
(280 464)
(277 473)
1,321
1,419
1,350
1,276
19.6
28.7
29.9
34.4
(17.3 22.2)
(24.5 33.7)
(23.8 37.4)
(28.3 41.8)
<LOD
2.60
1.88
3.45
(<LOD 3.88)
(<LOD 2.68)
(2.15 3.97)
23.2
31.0
33.8
35.3
(19.8 28.6)
(27.0 36.9)
(26.7 42.4)
(30.9 39.6)
193
220
240
314
(164 233)
(157 338)
(211 401)
(245 578)
791
679
653
634
16.5
24.5
28.4
24.3
(13.9 19.5)
(19.4 30.8)
(24.2 33.3)
(20.5 28.9)
<LOD
1.76
3.18
1.66
(<LOD 3.48)
(2.04 3.81)
(.980 2.91)
18.4
27.0
30.1
25.3
(14.4 22.8)
(22.6 33.4)
(26.1 36.0)
(22.1 30.3)
173
157
202
186
(136 311)
(127 387)
(158 230)
(147 251)
597
692
681
662
28.7
35.2
39.5
39.2
(24.5 33.6)
(31.5 39.4)
(34.5 45.3)
(33.3 46.1)
<LOD
2.50
2.71
2.99
(<LOD 2.90)
(2.21 3.73)
(.537 5.09)
34.4
40.8
45.5
45.0
(28.9 39.3)
(34.4 46.8)
(38.4 53.4)
(39.4 50.2)
252
225
299
330
(210 366)
(198 276)
(249 402)
(284 441)
899
1,211
1,069
1,039
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
424
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
600
400
H
H
H
200
H
H
H
H
H
H
H
H
H
H
0
60
H
50th Percentile
H
H
40
H
H
H
H
20
0
10
4
H
H
H
H
H
H
H
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
425
426
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
315
299
287
307
275
340
303
272
271
327
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
290
(282 352)
(270 331)
(256 322)
(275 343)
(242 313)
(287 403)
(270 339)
(236 314)
(231 317)
(288 371)
(266 317)
6.62
5.73
5.56
5.60
5.15
11.4
5.99
6.15
3.90
5.82
5.51
(5.35 9.21)
(2.54 6.66)
(3.56 7.65)
(3.53 8.21)
(3.46 6.73)
(3.72 23.1)
(4.82 9.04)
(2.81 9.09)
(2.39 5.55)
(1.91 9.57)
(3.93 6.69)
16.7
11.0
11.0
12.5
10.3
25.6
14.0
10.8
7.59
14.1
10.9
(8.05 25.3)
(6.72 15.2)
(8.84 16.5)
(9.00 15.7)
(8.69 14.3)
(13.5 35.2)
(8.09 18.1)
(7.26 17.6)
(4.89 12.1)
(8.96 17.7)
(9.27 14.5)
402
421
387
424
364
413
394
349
389
476
390
(364 435)
(365 469)
(336 447)
(378 468)
(321 422)
(334 503)
(363 445)
(307 413)
(310 461)
(396 559)
(350 435)
2,410
2,300
2,740
2,850
2,630
2,150
2,560
2,810
3,050
2,690
2,740
(2,040 2,940)
(2,210 2,670)
(2,510 3,130)
(2,600 3,150)
(2,360 3,070)
(1,770 2,590)
(2,020 2,900)
(2,460 3,380)
(2,470 3,640)
(2,360 3,330)
(2,560 2,980)
3,300
3,140
3,850
3,790
3,780
2,670
3,290
3,930
4,130
3,460
3,800
(2,670 4,760)
(2,820 3,770)
(3,350 4,520)
(3,210 4,530)
(3,190 5,400)
(2,250 4,230)
(2,860 4,900)
(3,330 6,420)
(3,220 5,180)
(2,960 5,610)
(3,390 4,340)
1,287
1,343
2,108
2,496
2,626
692
1,422
1,137
901
970
5,122
Geometric mean and selected percentiles of urine concentrations (in g/L) for the total U.S. population aged 6 years and older, National Health and
Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
200
400
600
Females
Males
Urinary enterolactone
(g/L)
800
Overall
611
1219
2039
4059
60+
611
2039
4059
60+
NonHispanic Whites
600
400
200
0
Urinary enterolactone
(g/L)
800
NonHispanic Blacks
1219
611
1219
2039
4059
60+
611
1219
4059
60+
Males
200
400
600
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary enterolactone
(g/L)
800
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
427
290
340
303
272
271
327
(266 317)
(287 403)
(270 339)
(236 314)
(231 317)
(288 371)
26.5
56.2
27.3
26.5
19.8
30.1
(23.0 30.9)
(32.4 76.6)
(19.2 44.1)
(20.2 35.4)
(14.2 26.7)
(18.9 42.3)
390
413
394
349
389
476
(350 435)
(334 503)
(363 445)
(307 413)
(310 461)
(396 559)
1,810
1,490
1,680
1,780
1,950
2,020
(1,700 1,970)
(1,200 1,880)
(1,490 1,910)
(1,540 2,060)
(1,560 2,430)
(1,790 2,300)
5,122
692
1,422
1,137
901
970
307
408
318
259
297
373
(275 343)
(324 514)
(272 371)
(211 318)
(241 365)
(318 438)
28.8
79.9
28.6
26.2
21.7
38.9
(23.3 36.5)
(45.3 126)
(20.1 51.1)
(16.7 37.4)
(12.8 32.5)
(20.7 59.7)
424
481
418
334
427
551
(378 468)
(381 582)
(369 495)
(244 427)
(309 537)
(441 651)
1,910
1,520
1,800
1,790
2,050
2,040
(1,730 2,060)
(1,140 2,130)
(1,530 2,240)
(1,530 2,320)
(1,530 2,950)
(1,690 2,720)
2,496
340
728
499
451
478
275
280
288
286
248
294
(242 313)
(233 336)
(250 331)
(242 337)
(197 313)
(239 362)
24.6
32.3
23.3
27.3
19.3
26.8
(19.9 28.9)
(24.1 57.3)
(16.5 47.6)
(20.2 38.7)
(10.8 26.6)
(16.3 41.8)
364
346
372
354
349
424
(321 422)
(260 445)
(320 421)
(311 443)
(271 421)
(323 541)
1,770
1,420
1,520
1,760
1,840
2,010
(1,540 2,000)
(1,080 2,230)
(1,370 1,730)
(1,360 2,500)
(1,450 2,330)
(1,700 2,280)
2,626
352
694
638
450
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
315
278
344
329
295
305
(282 352)
(238 325)
(288 411)
(276 393)
(220 396)
(192 484)
39.4
53.7
54.9
38.9
28.5
29.7
(28.0 48.8)
(36.8 70.2)
(36.7 77.6)
(21.1 56.1)
(12.0 43.9)
(6.75 60.8)
402
348
447
389
411
438
(364 435)
(265 403)
(386 526)
(334 471)
(286 578)
(204 673)
1,630
1,100
1,590
1,900
1,510
1,800
(1,460 1,930)
(898 1,510)
(1,280 2,050)
(1,470 2,650)
(1,260 2,150)
(1,270 5,730)
1,287
231
445
282
157
172
320
305
331
303
340
399
(276 372)
(243 382)
(249 440)
(224 411)
(230 504)
(215 739)
38.3
55.3
46.6
25.1
28.6
38.2
(25.0 51.0)
(34.8 94.5)
(31.6 67.2)
(6.52 63.5)
(12.2 44.6)
(4.50 106)
423
367
441
390
540
521
(362 501)
(243 433)
(325 562)
(276 518)
(286 673)
(205 1,080)
1,700
1,210
1,660
1,890
1,500
2,030
(1,490 2,030)
(862 1,960)
(1,180 2,480)
(1,350 2,780)
(1,250 3,450)
(1,350 6,680)
625
112
228
117
85
83
309
252
358
363
253
245
(268 356)
(201 316)
(286 449)
(283 466)
(177 360)
(142 423)
43.0
46.3
65.0
45.0
21.0
18.4
(21.6 57.0)
(32.3 56.2)
(31.6 94.3)
(14.8 74.7)
(5.66 44.2)
(5.17 52.4)
366
319
446
383
317
267
(317 436)
(243 407)
(356 567)
(310 566)
(192 525)
(149 676)
1,560
1,010
1,460
1,900
1,440
1,690
(1,280 1,960)
(776 1,740)
(1,160 2,040)
(1,260 3,510)
(920 3,070)
(994 3,320)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
428
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
299
429
370
264
248
349
(270 331)
(362 509)
(335 408)
(215 326)
(195 316)
(267 455)
26.0
117
46.6
23.0
19.8
39.2
(21.3 43.2)
(55.9 164)
(30.1 64.8)
(10.3 45.2)
(7.86 31.8)
(14.7 66.3)
421
419
523
437
326
551
(365 469)
(348 565)
(472 569)
(305 538)
(239 423)
(368 611)
1,580
1,560
1,640
1,410
1,630
1,760
(1,450 1,790)
(1,350 2,070)
(1,460 1,970)
(1,210 2,230)
(1,390 2,210)
(1,270 2,330)
1,343
207
496
249
231
160
320
425
397
287
288
295
(272 375)
(348 519)
(345 457)
(212 389)
(198 419)
(191 456)
30.8
123
58.9
24.9
16.4
17.8
(17.1 56.8)
(89.3 164)
(34.1 79.3)
(6.85 46.6)
(2.90 78.2)
(4.36 60.4)
439
363
502
444
344
520
(339 549)
(303 558)
(412 605)
(248 595)
(236 698)
(287 646)
1,740
1,460
1,770
1,860
1,880
1,290
(1,480 2,210)
(1,320 2,160)
(1,420 2,810)
(1,430 3,290)
(1,380 2,860)
(1,080 2,200)
661
99
258
116
114
74
282
434
344
247
220
387
(253 315)
(324 582)
(294 402)
(187 327)
(166 291)
(271 553)
23.9
94.1
33.9
18.0
21.5
44.3
(18.9 43.7)
(22.9 174)
(15.3 59.8)
(8.47 45.5)
(6.67 39.7)
(10.3 109)
418
531
530
421
303
575
(356 464)
(364 624)
(439 596)
(246 540)
(178 410)
(365 666)
1,470
1,590
1,590
1,180
1,530
1,770
(1,310 1,750)
(1,140 2,390)
(1,350 1,910)
(934 1,760)
(1,140 2,250)
(1,430 2,340)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
287
355
292
254
266
347
(256 322)
(279 452)
(248 344)
(207 312)
(219 323)
(301 401)
26.3
56.3
27.1
26.3
19.1
33.4
(22.3 31.2)
(25.8 99.3)
(17.2 54.8)
(18.2 35.4)
(12.2 26.9)
(20.6 45.2)
387
456
369
313
393
495
(336 447)
(279 562)
(325 424)
(235 389)
(300 480)
(427 588)
1,810
1,480
1,660
1,640
1,850
2,060
(1,650 2,010)
(1,100 2,250)
(1,390 1,950)
(1,410 2,290)
(1,510 2,440)
(1,800 2,400)
2,108
193
378
494
448
595
308
454
304
234
303
404
(265 358)
(328 629)
(245 379)
(173 316)
(232 397)
(339 482)
29.4
97.2
27.8
25.4
22.0
40.6
(22.9 38.0)
(29.3 181)
(10.6 56.7)
(9.45 38.0)
(9.47 38.6)
(21.8 72.4)
434
528
391
269
437
596
(374 489)
(338 805)
(337 493)
(194 400)
(304 578)
(454 697)
1,900
1,560
1,760
1,570
2,130
2,080
(1,660 2,160)
(1,070 2,670)
(1,360 2,340)
(1,300 2,460)
(1,580 2,880)
(1,700 2,780)
1,035
99
191
217
229
299
268
267
279
277
232
308
(227 316)
(199 358)
(224 347)
(224 342)
(177 305)
(245 388)
24.6
26.4
21.0
26.9
17.1
29.2
(19.0 29.0)
(12.5 71.6)
(14.5 64.0)
(19.5 35.1)
(8.39 26.9)
(17.2 42.6)
350
278
336
335
348
434
(294 415)
(207 488)
(257 404)
(264 408)
(220 423)
(323 570)
1,760
1,390
1,540
1,770
1,730
2,040
(1,450 2,090)
(1,040 3,010)
(1,020 1,990)
(1,230 2,790)
(1,250 2,200)
(1,690 2,360)
1,073
94
187
277
219
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
429
239
259
298
283
(200 286)
(233 287)
(265 334)
(245 327)
8.77
9.27
13.9
9.40
(4.68 13.0)
(6.84 11.8)
(10.0 17.9)
(5.54 14.3)
315
350
395
384
(246 380)
(314 389)
(332 462)
(339 456)
2,800
2,720
2,620
2,880
(2,520 3,200)
(1,970 3,440)
(2,370 2,980)
(2,540 3,170)
2,548
2,794
2,594
2,528
308
288
384
300
(219 432)
(245 339)
(287 513)
(242 373)
34.7
23.4
36.1
19.6
354
329
414
390
(243 473)
(275 405)
(303 557)
(279 544)
2,790
2,190
2,300
1,890
(1,850 4,390)
(1,520 2,610)
(1,750 3,760)
(1,420 2,630)
331
396
341
351
250
267
314
292
(191 327)
(231 308)
(267 369)
(245 348)
10.0
16.1
18.4
9.91
(3.06 16.5)
(10.1 20.0)
(6.64 26.0)
(5.93 14.9)
316
318
399
393
(244 408)
(256 398)
(335 461)
(350 490)
2,920
2,170
2,620
2,320
(2,270 4,630)
(1,620 3,480)
(2,120 3,080)
(1,830 3,090)
746
744
729
693
231
242
279
265
(182 293)
(196 301)
(224 349)
(218 322)
8.06
8.89
14.1
9.63
(1.33 17.0)
(6.56 10.9)
(6.47 23.0)
(4.72 19.0)
303
335
372
337
(228 380)
(263 419)
(289 474)
(276 381)
2,660
2,890
2,500
3,130
(2,310 4,310)
(1,870 4,740)
(1,830 3,330)
(2,410 7,470)
535
604
554
583
211
250
271
270
(161 278)
(187 333)
(231 319)
(203 360)
2.50
7.35
10.2
5.04
(.690 7.44)
(3.98 11.5)
(7.40 12.5)
(2.73 13.3)
297
369
372
397
(229 401)
(278 429)
(281 429)
(299 539)
2,970
2,880
2,720
3,060
(2,250 5,070)
(1,870 4,820)
(2,350 4,400)
(2,260 4,030)
420
531
452
449
261
288
327
327
(205 331)
(247 334)
(287 372)
(260 410)
10.3
8.74
17.3
11.9
(4.10 18.7)
(3.09 17.8)
(9.92 21.1)
(6.63 17.1)
315
386
457
507
(238 417)
(311 451)
(367 547)
(374 632)
2,680
2,450
2,690
2,680
(2,240 4,580)
(1,710 3,460)
(2,360 3,170)
(2,070 4,400)
516
519
518
452
254
262
314
301
(212 304)
(233 295)
(280 351)
(247 368)
10.4
9.23
17.8
9.40
(6.45 12.8)
(6.76 10.9)
(10.7 21.9)
(4.26 14.9)
351
339
424
421
(266 417)
(314 386)
(375 474)
(347 512)
2,720
3,040
2,610
3,110
(2,460 3,480)
(2,310 4,570)
(2,120 3,340)
(2,750 3,520)
1,219
1,375
1,244
1,252
226
255
283
267
(180 284)
(226 288)
(233 343)
(220 324)
6.64
9.25
10.5
9.18
(.711 16.8)
(5.66 13.9)
(9.33 15.6)
(6.13 15.1)
287
356
369
357
(237 340)
(298 397)
(282 464)
(318 444)
2,810
2,190
2,620
2,650
(2,280 4,450)
(1,720 3,140)
(2,270 3,420)
(2,210 3,340)
1,329
1,419
1,350
1,276
212
275
275
359
(169 265)
(221 342)
(239 316)
(311 415)
6.58
12.6
9.35
26.7
(.710 13.4)
(4.92 26.8)
(6.08 15.6)
(18.2 38.6)
281
347
375
418
(232 338)
(313 395)
(316 434)
(363 514)
2,690
2,320
2,240
2,640
(2,430 3,350)
(1,650 3,490)
(1,920 3,170)
(2,010 3,390)
813
679
653
634
262
279
324
276
(194 352)
(224 347)
(282 372)
(237 322)
8.91
7.85
15.5
7.55
(.671 17.0)
(3.49 15.7)
(6.01 26.1)
(5.86 11.4)
360
420
425
410
(293 449)
(339 488)
(358 525)
(346 483)
2,480
1,980
2,230
2,560
(1,990 4,170)
(1,690 2,530)
(1,960 2,630)
(2,210 3,030)
594
692
681
662
247
268
301
274
(196 312)
(236 305)
(256 355)
(228 329)
8.26
9.30
16.3
9.17
(2.25 15.6)
(6.94 11.8)
(10.1 19.8)
(4.29 14.8)
317
356
397
372
(241 401)
(308 398)
(307 490)
(318 459)
2,990
2,780
2,650
2,900
(2,530 4,070)
(1,960 3,810)
(2,340 3,340)
(2,420 3,340)
901
1,211
1,069
1,039
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
430
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
95th Percentile
4000
3000
j
j
j
j
2000
j
j
j
j
j
j
j
j
j
j
1000
600
50th Percentile
500
300
400
j
j
j
j
200
80
40
j
j
20
j
j
j
j
j
j
j
j
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
0
9900
0102
0304
0506
5th Percentile
60
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
431
432
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Mexican Americans
Non-Hispanic Blacks
Non-Hispanic Whites
Race/ethnicity
Males
Females
284
210
292
244
313
368
225
232
274
383
611 years
1219 years
2039 years
4059 years
60 years and older
Gender
277
(251 322)
(189 233)
(258 331)
(216 275)
(275 357)
(312 434)
(203 250)
(200 269)
(231 326)
(334 438)
(252 305)
5.88
4.37
5.97
4.80
6.82
14.6
6.79
4.10
4.59
6.04
5.55
(3.39 8.31)
(2.46 5.15)
(3.88 8.66)
(2.78 6.36)
(4.83 8.44)
(7.65 30.5)
(4.71 8.45)
(2.40 8.49)
(2.61 6.17)
(2.51 9.36)
(4.13 6.95)
14.6
7.91
12.6
10.7
11.3
33.6
11.3
9.56
8.62
13.5
11.2
(9.01 21.8)
(5.58 10.8)
(9.39 14.6)
(6.43 13.5)
(9.39 15.4)
(21.0 47.1)
(7.51 14.7)
(6.42 13.7)
(5.64 13.1)
(8.69 18.9)
(9.15 13.5)
366
294
406
336
418
463
290
314
366
582
375
(331 417)
(274 325)
(350 469)
(298 371)
(360 481)
(382 535)
(271 307)
(273 363)
(323 468)
(502 671)
(341 418)
1,920
1,480
2,730
2,110
2,890
2,120
1,470
2,440
2,870
2,780
2,500
(1,670 2,260)
(1,340 1,670)
(2,330 3,370)
(1,930 2,310)
(2,560 3,740)
(1,770 2,530)
(1,330 1,790)
(1,860 3,750)
(2,260 4,000)
(2,480 3,620)
(2,250 2,890)
2,350
2,020
4,180
2,930
4,590
2,630
2,180
3,780
4,880
4,110
3,780
(2,110 3,390)
(1,690 2,300)
(3,430 5,250)
(2,440 3,460)
(3,880 5,900)
(2,300 3,430)
(1,580 3,540)
(2,880 5,890)
(3,470 6,600)
(3,400 5,060)
(3,380 4,390)
1,287
1,343
2,108
2,496
2,626
692
1,422
1,137
901
970
5,122
Geometric mean and selected percentiles of urine concentrations (in g/g creatinine) for the total U.S. population aged 6 years and older, National
Health and Nutrition Examination Survey, 20032006.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
600
200
400
Females
Males
Urinary enterolactone
(g/g creatinine)
800
Overall
611
1219
2039
4059
60+
611
NonHispanic Blacks
1219
2039
4059
60+
600
400
200
0
Urinary enterolactone
(g/g creatinine)
800
NonHispanic Whites
611
1219
2039
4059
60+
611
1219
4059
60+
Males
600
200
400
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Urinary enterolactone
(g/g creatinine)
800
Females
2039
611
1219
2039
Age (years)
4059
60+
611
1219
2039
4059
60+
Age (years)
433
277
368
225
232
274
383
(252 305)
(312 434)
(203 250)
(200 269)
(231 326)
(334 438)
26.1
79.9
22.6
20.0
21.1
33.8
(20.3 31.3)
(44.5 104)
(18.0 36.1)
(15.1 28.5)
(15.4 28.7)
(22.8 46.9)
375
463
290
314
366
582
(341 418)
(382 535)
(271 307)
(273 363)
(323 468)
(502 671)
1,620
1,480
1,140
1,460
1,720
2,130
(1,480 1,800)
(1,200 1,900)
(996 1,220)
(1,250 1,720)
(1,510 2,100)
(1,840 2,310)
5,122
692
1,422
1,137
901
970
244
409
215
189
235
344
(216 275)
(329 508)
(188 247)
(152 234)
(187 296)
(289 409)
21.0
91.0
20.9
16.8
18.5
35.8
(16.3 28.5)
(45.7 127)
(13.6 34.9)
(11.7 21.7)
(12.7 30.6)
(16.2 57.6)
336
471
292
257
328
522
(298 371)
(395 622)
(258 312)
(209 315)
(267 417)
(452 576)
1,400
1,380
1,150
1,290
1,450
1,720
(1,290 1,580)
(1,190 2,000)
(924 1,390)
(1,050 1,610)
(1,230 1,930)
(1,490 2,210)
2,496
340
728
499
451
478
313
329
237
284
316
417
(275 357)
(271 399)
(208 270)
(237 340)
(253 395)
(336 517)
30.0
56.3
25.5
30.8
23.7
28.3
(22.8 35.5)
(31.6 89.2)
(14.5 43.8)
(15.9 42.8)
(15.5 32.1)
(19.4 53.4)
418
431
285
377
424
636
(360 481)
(324 515)
(251 320)
(315 431)
(334 585)
(511 784)
1,840
1,660
1,080
1,640
2,130
2,290
(1,640 2,210)
(1,080 2,310)
(918 1,230)
(1,360 2,360)
(1,580 2,940)
(2,020 2,730)
2,626
352
694
638
450
492
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
284
349
266
266
270
376
(251 322)
(304 400)
(225 315)
(218 324)
(203 358)
(246 576)
37.6
79.6
40.1
29.6
25.4
29.4
(27.2 48.7)
(57.9 113)
(26.8 56.0)
(14.6 47.7)
(10.6 46.6)
(8.02 89.3)
366
404
343
328
400
487
(331 417)
(338 472)
(286 397)
(257 408)
(291 589)
(332 761)
1,410
1,330
1,160
1,480
1,190
1,800
(1,240 1,620)
(1,020 1,670)
(986 1,320)
(1,210 1,940)
(898 1,770)
(1,550 2,210)
1,287
231
445
282
157
172
253
365
240
220
249
355
(219 291)
(292 457)
(185 312)
(167 290)
(174 358)
(200 631)
31.0
88.4
31.2
27.2
23.3
37.2
(22.9 44.1)
(58.8 127)
(18.5 42.9)
(3.66 48.2)
(6.34 49.2)
(3.60 128)
334
403
289
257
399
503
(287 401)
(290 494)
(241 375)
(222 396)
(235 603)
(322 714)
1,210
1,390
1,170
1,270
898
1,540
(1,020 1,480)
(956 1,970)
(928 1,530)
(930 1,900)
(841 1,530)
(1,100 6,820)
625
112
228
117
85
83
322
332
296
332
294
395
(275 378)
(267 413)
(235 372)
(257 430)
(209 414)
(235 663)
40.7
64.3
57.9
39.7
28.5
25.8
(28.9 66.8)
(34.7 110)
(30.5 99.0)
(17.2 71.6)
(3.25 64.6)
(5.58 112)
382
401
378
361
374
487
(331 484)
(311 538)
(316 443)
(292 548)
(215 655)
(197 1,220)
1,600
1,130
1,100
1,630
1,390
1,880
(1,330 1,870)
(861 1,830)
(860 1,350)
(1,300 3,210)
(1,090 2,590)
(1,590 4,100)
662
119
217
165
72
89
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
434
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
210
403
212
164
180
311
(189 233)
(342 476)
(194 232)
(133 201)
(143 228)
(242 399)
20.2
126
30.8
15.8
11.8
25.1
(13.8 30.9)
(82.0 147)
(19.9 38.3)
(10.5 22.2)
(5.52 24.1)
(12.7 61.0)
294
469
282
263
264
489
(274 325)
(378 550)
(251 313)
(194 306)
(207 321)
(325 693)
1,080
1,300
843
914
1,080
1,430
(995 1,210)
(1,080 1,660)
(755 1,010)
(741 1,040)
(933 1,390)
(1,210 1,770)
1,343
207
496
249
231
160
187
401
212
138
165
217
(157 222)
(329 489)
(186 243)
(103 185)
(114 238)
(142 330)
20.0
122
31.8
12.2
10.2
14.8
(11.2 31.3)
(69.6 153)
(19.4 44.2)
(2.62 27.1)
(3.65 35.8)
(3.29 51.0)
267
417
264
192
233
329
(223 305)
(332 523)
(222 301)
(113 291)
(167 305)
(249 440)
1,050
1,220
923
969
1,040
1,090
(940 1,200)
(1,020 1,730)
(767 1,320)
(657 1,180)
(711 1,440)
(842 3,370)
661
99
258
116
114
74
231
405
212
188
195
391
(207 259)
(308 532)
(180 250)
(144 246)
(147 258)
(275 557)
20.3
127
26.0
16.1
11.4
40.6
(13.3 35.8)
(20.6 163)
(11.1 39.8)
(7.55 32.9)
(5.89 33.6)
(9.12 96.7)
317
512
299
276
289
707
(286 349)
(386 585)
(249 360)
(197 347)
(205 392)
(327 822)
1,150
1,360
814
820
1,170
1,620
(974 1,410)
(898 2,610)
(727 927)
(619 1,360)
(928 1,600)
(1,380 2,090)
682
108
238
133
117
86
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
292
385
229
234
286
415
(258 331)
(305 486)
(196 267)
(188 292)
(232 352)
(358 480)
26.3
80.8
22.7
18.7
22.5
38.5
(20.0 31.5)
(35.3 113)
(14.2 39.5)
(12.5 29.1)
(14.8 30.7)
(23.7 57.9)
406
467
277
319
379
611
(350 469)
(367 615)
(247 318)
(258 417)
(323 500)
(529 717)
1,680
1,380
1,150
1,550
1,810
2,210
(1,510 2,020)
(1,170 2,000)
(959 1,320)
(1,200 2,350)
(1,500 2,210)
(1,850 2,610)
2,108
193
378
494
448
595
258
440
217
185
254
377
(219 304)
(322 602)
(178 265)
(134 256)
(190 338)
(313 454)
20.6
111
20.8
16.1
18.8
38.1
(16.0 30.1)
(32.6 149)
(13.2 36.5)
(5.82 20.9)
(12.8 34.3)
(18.3 61.4)
360
478
295
263
338
551
(309 418)
(380 740)
(230 345)
(176 362)
(267 497)
(467 666)
1,490
1,330
1,150
1,330
1,570
1,820
(1,320 1,680)
(1,150 2,850)
(843 1,400)
(1,010 2,350)
(1,270 2,040)
(1,480 2,430)
1,035
99
191
217
229
299
330
330
242
296
322
447
(280 389)
(250 436)
(198 296)
(236 373)
(247 419)
(355 562)
31.3
57.0
28.8
30.0
25.9
35.6
(23.1 39.4)
(24.7 98.5)
(12.4 75.4)
(13.3 48.8)
(15.8 32.6)
(21.3 69.1)
447
427
264
417
445
662
(375 526)
(257 554)
(238 320)
(312 470)
(323 614)
(529 845)
1,990
1,690
1,180
1,690
2,130
2,400
(1,660 2,530)
(1,010 2,420)
(909 1,350)
(1,250 3,260)
(1,500 3,470)
(2,090 3,040)
1,073
94
187
277
219
296
Males
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
Females
Total, 6 years and older
611 years
1219 years
2039 years
4059 years
60 years and older
435
218
243
279
276
(184 260)
(220 268)
(245 317)
(237 321)
7.15
7.63
12.3
9.89
(4.06 9.89)
(5.19 10.3)
(9.27 14.5)
(6.76 13.8)
284
323
371
382
(247 336)
(293 360)
(325 430)
(330 447)
2,250
2,120
2,400
2,640
(1,890 2,930)
(1,790 2,460)
(2,030 2,890)
(2,260 3,380)
2,548
2,794
2,594
2,528
315
327
409
331
(238 416)
(274 391)
(310 540)
(268 408)
38.6
27.3
41.0
23.4
(<LOD 66.8)
(10.5 59.2)
(11.1 79.7)
(8.67 46.6)
380
349
469
456
(269 431)
(264 477)
(356 628)
(326 526)
2,040
1,980
2,300
1,820
(1,640 3,510)
(1,570 3,360)
(1,750 3,390)
(1,580 2,970)
331
396
341
351
169
206
235
216
(133 214)
(178 239)
(202 273)
(184 254)
6.86
12.2
14.7
9.50
(2.00 13.6)
(7.63 14.1)
(6.78 20.2)
(5.93 13.1)
209
254
285
296
(172 263)
(224 292)
(256 307)
(254 335)
1,820
1,500
1,510
1,410
(1,340 2,460)
(1,240 2,730)
(1,310 2,700)
(1,170 1,890)
746
744
729
693
183
196
235
229
(143 235)
(160 240)
(186 299)
(187 279)
5.46
4.83
10.0
9.40
(.836 8.94)
(2.86 9.88)
(4.07 14.8)
(4.07 16.0)
248
298
324
299
(199 291)
(251 334)
(250 422)
(256 348)
1,900
1,670
2,140
2,630
(1,480 3,890)
(1,430 2,450)
(1,640 3,890)
(1,680 6,020)
535
604
554
583
215
248
260
288
(165 279)
(191 321)
(218 310)
(213 389)
4.14
5.90
8.64
8.45
(1.49 8.85)
(3.49 10.7)
(6.33 13.5)
(3.84 13.9)
282
335
354
394
(244 375)
(266 435)
(300 444)
(306 602)
2,520
2,450
2,450
3,380
(2,030 4,780)
(1,600 4,940)
(2,010 4,240)
(2,280 4,890)
420
531
452
449
313
341
387
379
(227 432)
(296 392)
(330 453)
(300 478)
14.0
9.15
18.4
11.9
(3.73 20.9)
(4.22 17.6)
(10.5 21.5)
(6.12 17.7)
431
432
547
597
(312 611)
(383 476)
(439 682)
(495 730)
2,530
2,550
2,690
3,030
(1,940 4,500)
(2,130 3,030)
(2,340 3,340)
(2,250 4,480)
516
519
518
452
199
213
245
243
(170 234)
(191 238)
(215 280)
(196 300)
7.25
6.70
12.8
8.40
(3.82 9.99)
(4.49 9.78)
(9.17 14.8)
(4.08 13.6)
262
287
330
336
(231 309)
(256 317)
(289 372)
(280 416)
2,020
1,960
2,030
2,200
(1,810 2,480)
(1,620 2,660)
(1,770 2,390)
(1,930 2,640)
1,219
1,375
1,244
1,252
238
274
314
313
(191 297)
(241 312)
(257 385)
(261 375)
7.08
9.46
11.2
12.4
(2.40 14.0)
(5.43 13.8)
(8.54 17.0)
(9.39 15.7)
303
356
414
419
(263 378)
(314 405)
(330 501)
(342 527)
2,550
2,140
2,810
3,080
(2,010 3,520)
(1,970 2,430)
(2,290 3,940)
(2,520 4,780)
1,329
1,419
1,350
1,276
194
259
248
324
(165 228)
(213 314)
(217 282)
(267 393)
3.78
13.0
6.88
26.3
(2.01 15.3)
(3.24 23.2)
(4.10 14.5)
(13.0 36.2)
253
361
349
378
(224 282)
(298 409)
(310 397)
(321 471)
2,020
1,630
1,800
2,030
(1,700 2,810)
(1,320 3,010)
(1,470 2,260)
(1,680 2,770)
813
679
653
634
168
195
228
193
(124 226)
(153 248)
(194 268)
(167 223)
3.12
6.71
10.8
6.32
(.422 9.24)
(4.02 9.33)
(4.54 17.1)
(4.70 8.61)
215
303
300
285
(175 276)
(257 334)
(274 341)
(249 330)
1,590
1,460
1,460
1,490
(1,220 3,280)
(1,110 1,730)
(1,220 2,110)
(1,290 1,660)
594
692
681
662
243
265
297
288
(194 304)
(232 302)
(248 356)
(238 347)
7.71
7.97
13.5
11.0
(3.26 11.8)
(5.19 11.8)
(9.57 17.5)
(5.96 14.9)
324
340
409
403
(280 389)
(299 393)
(331 492)
(329 497)
2,490
2,400
2,590
2,910
(2,010 3,540)
(1,980 2,900)
(2,040 3,380)
(2,310 4,180)
901
1,211
1,069
1,039
Age group
611 years
19992000
20012002
20032004
20052006
1219 years
19992000
20012002
20032004
20052006
2039 years
19992000
20012002
20032004
20052006
4059 years
19992000
20012002
20032004
20052006
Gender
Males
19992000
20012002
20032004
20052006
Females
19992000
20012002
20032004
20052006
Race/ethnicity
Mexican Americans
19992000
20012002
20032004
20052006
Non-Hispanic Blacks
19992000
20012002
20032004
20052006
Non-Hispanic Whites
19992000
20012002
20032004
20052006
< LOD means less than the limit of detection for the uncorrected urine values, which may vary for some compounds by year. See Appendix D for LOD.
436
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
5000
95th Percentile
4000
3000
H
H
H
2000
H
H
H
H
H
H
H
H
H
H
H
H
1000
800
50th Percentile
600
H
400
H
H
200
H
H
H
H
0
80
40
H
20
H
H
H
H
H
H
H
H
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
9900
0102
0304
0506
5th Percentile
60
Total
(6+y)
35y
611y
1219y
20+y
Males
Females
MA
NHB
NHW
Values in the graph are suppressed if either the point estimate or the lower 95% confidence limit is noted as < LOD in the accompanying table.
437
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Nielsen ILF, Williamson G. Review of the factors affecting bioavailability of soy isoflavones in humans. Nutr
Cancer. 2007;57:110.
Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on
blood lipids. Am J Clin Nutr. 2009;90:288297.
Parker DL, Rybak ME, Pfeiffer CM. Phytoestrogen biomonitoring: an extractionless LC-MS/MS method for
measuring urinary isoflavones and lignans using atmospheric pressure photoionization (APPI). Anal Bioanal Chem.
2012;402:11231136.
Prez-Jimnez J, Hubert J, Hooper L, Cassidy A, Manach C, Williamson G, Scalbert A. Urinary metabolites as
biomarkers of polyphenol intake in humans: a systematic review. Am J Clin Nutr. 2010;92:801809.
Peterson J, Dwyer J, Adlercreutz A, Scalbert A, Jacques P, Mccullough ML. Dietary lignans: physiology and
potential for cardiovascular disease risk reduction. Nutr Rev. 2010;68:571603.
Rowland IR, Wiseman H, Sanders TAB, Adlercreutz H, Bowey EA. Interindividual variation in metabolism of
soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer.
2000;36:2732.
Rowland I, Faughnan M, Hoey L, Wahala K, Williamson G, Cassidy A. Bioavailability of phyto-estrogens. Br J
Nutr. 2003;89(Suppl 1):S45S58.
Rozman KK, Bhatia J, Calafat AM, Chambers C, Culty M, Etzel RA, et al. NTP-CERHR expert panel report on
the reproductive and developmental toxicity of soy formula. Birth Defects Res. (Part B) 2006a;77:280397.
Rozman KK, Bhatia J, Calafat AM, Chambers C, Culty M, Etzel RA, et al. NTP-CERHR expert panel report on
the reproductive and developmental toxicity of genistein. Birth Defects Res. (Part B) 2006b;77:485638.
Rybak ME, Parker DL, Pfeiffer CM. Determination of urinary phytoestrogens by HPLC-MS/MS: a comparison
of atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI). J Chromatogr B.
2008;861:145150.
Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. Exposure of infants to phyto-oestrogens from soy-based
infant formula. Lancet. 1997;350:2327.
Setchell KD, Briwb NM, Lydeking-Olsen E. The clinical importance of the metabolite equol a clue to the
effectiveness of soy and its isoflavones. J Nutr. 2002;132:35773584.
Setchell KDR, Brown NM, Desai PB, Zimmer-Nechimias L, Wolfe B, Jakate AS, et al. Bioavailability, disposition,
and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary
intakes. J Nutr. 2003a; 133:10271035.
Setchell KDR, Faughnan MS, Acades T, Zimmer-Nechemias L, Brown NM, Wolfe BE, et al. Comparing the
pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. Am J
Clin Nutr. 2003b;77:411419.
Setchell KD, Cole SJ. Method of defining equol-producer status and its frequency among vegetarians. J Nutr.
2006;136:21882193.
Strom BL, Schinnar R, Ziegler EE, Barnhart KT, Sammel MD, Macones GA, et al. Exposure to soy-based formula
in infancy and endocrinological and reproductive outcomes in young adulthood. JAMA. 2001;286:807814.
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L54PHY_D.htm.
U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for
th
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Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal
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Valentin-Blasini L, Sadowski MA, Walden D, Caltabiano L, Needham LL, Barr DB. Urinary phytoestrogen
concentrations in the U.S. population (19992000). J Exposure Anal Environ Epidemiol. 2005;15:509523.
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440
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
5. Acrylamide Hemoglobin
Adducts
Acrylamide
Glycidamide
Glycidamide-to-acrylamide ratio
5. Acrylamide Adducts
443
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
exposure. Therefore, studies using these biomarkers to investigate acrylamide intake from foods
need to control for exposures from other sources, such as smoking. Persons who smoke tobacco
products have higher acrylamide exposure than those not smoking (Vesper 2007). Exposure to
second hand smoke seems to have a small but significant effect on hemoglobin adduct levels in
non-smokers (Vesper 2010).
Analytical methods measuring hemoglobin adducts of acrylamide determine the adducts
at the N-terminal valine of the hemoglobin protein chains. Initial methods employed gas
chromatography coupled with mass spectrometry; these methods were based on a modified
Edman reaction, which was first described for measuring N-terminal hemoglobin adducts of
ethylene oxide, propylene oxide, and styrene oxide (Mowrer 1986). These initial methods were
further developed and optimized to measure hemoglobin adducts of acrylamide and glycidamide
(Trnqvist 1986, Vesper 2006).
Data in NHANES. No data exist on acrylamide hemoglobin adduct concentrations in NHANES
prior to 2003. This report shows first-time NHANES data for hemoglobin adducts of acrylamide
and glycidamide. Data presented in this report were generated by use of high-performance liquid
chromatography coupled to tandem mass spectrometry (LC-MS/MS); this method uses stable
isotope labeled peptide adducts (same amino acid sequence as hemoglobin) of acrylamide and
glycidamide as internal standards (Vesper 2008).
Highlights
The first-time acrylamide hemoglobin adduct concentrations in the U.S. population showed the
following demographic patterns and characteristics:
Hemoglobin adduct concentrations were detectable in 98% of all blood samples
measured.
We found demographic differences for the glycidamide-to-acrylamide hemoglobin
adduct ratios, but no consistent age, gender, or race/ethnicity patterns for the
hemoglobin adduct concentrations.
New data from NHANES 20032004 allow us for the first time to assess the exposure of the
U.S. population to acrylamide. Measurement of hemoglobin adducts provides information both
about acrylamide exposure and metabolism. The glycidamide-to-acrylamide hemoglobin adduct
ratio can be used as an indicator of the extent of acrylamide metabolism and thus as an indicator
of formation of the genotoxic metabolite glycidamide in the body and its detoxification. Children
had higher glycidamide-to-acrylamide hemoglobin adduct ratios compared to adolescents and
adults (Figure H.5.a), suggesting differences in acrylamide metabolism or metabolic rate among
age groups (Vesper 2010). Non-Hispanic blacks (NHB) had lower hemoglobin adduct ratios
compared to non-Hispanic whites (NHW) and Mexican Americans (MA), which may indicate
differences in polymorphisms of the genes involved in phase II detoxification of acrylamide and
glycidamide (Vesper 2010). More research is needed to better understand factors influencing
acrylamide metabolism and the relationship between acrylamide exposure and health risks.
5. Acrylamide Adducts
445
1.4
1.2
1
0.8
Age (years)
Gender
W
NH
NH
M
A
es
al
es
Fe
m
M
al
60
40
-5
9
20
-3
0
12
-1
9
611
35
To
ta
l
0.6
Race/ethnicity
Figure H.5.a. Geometric mean of glycidamide-to-acrylamide hemoglobin adduct ratio in the U.S. population aged 3 years and older,
National Health and Nutrition Examination Survey, 20032004.
Error bars represent 95 percent confidence intervals.
Detailed Observations
The selected observations mentioned below are derived from the tables and figures presented next.
Statements about categorical differences between demographic groups noted below are based on
non-overlapping confidence limits from univariate analysis without adjusting for demographic
variables (e.g., age, sex, race/ethnicity) or other blood concentration determinants (e.g., dietary
intake, supplement usage, smoking, BMI). A multivariate analysis may alter the size and statistical
significance of these categorical differences. Furthermore, additional significant differences of
smaller magnitude may be present despite their lack of mention here (e.g., if confidence limits
slightly overlap or if differences are not statistically significant before covariate adjustment has
occurred). For a selection of citations of descriptive NHANES papers related to these biochemical
indicators of diet and nutrition, see Appendix G.
446
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
5. Acrylamide Adducts
447
448
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(53.6 65.7)
(56.1 61.2)
(54.4 60.5)
(64.1 73.3)
(59.9 68.4)
(47.9 52.3)
(60.2 67.9)
(55.9 61.5)
(58.7 64.9)
(57.1 71.2)
(58.9 65.9)
63.9
58.7
61.7
63.8
62.3
(58.1 64.4)
59.4
58.6
57.4
68.5
64.0
50.1
61.2
Non-Hispanic Whites
Non-Hispanic Blacks
Mexican Americans
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
35 years
33.4
23.9
26.5
26.0
25.0
30.9
31.5
28.4
26.5
24.1
21.6
25.7
(29.4 35.5)
(23.1 24.7)
(24.1 27.7)
(23.0 28.0)
(23.3 26.2)
(28.9 34.0)
(27.2 35.1)
(25.7 29.8)
(23.9 28.4)
(22.2 27.0)
(19.1 23.3)
(23.7 26.8)
36.5
27.3
29.6
29.0
29.4
35.9
36.1
31.4
30.3
29.1
26.0
29.2
(34.5 38.3)
(26.0 29.1)
(28.2 31.3)
(27.2 31.1)
(27.9 30.3)
(29.7 38.0)
(32.2 38.7)
(30.0 32.6)
(28.0 31.7)
(26.1 31.2)
(23.2 27.2)
(27.6 30.5)
57.4
57.0
55.2
56.9
53.3
58.2
57.3
54.4
59.8
55.1
46.5
54.7
(54.4 60.3)
(51.9 64.0)
(52.9 58.5)
(53.6 60.0)
(51.8 55.8)
(52.5 64.7)
(55.1 59.6)
(52.1 57.3)
(57.0 63.9)
(52.1 59.1)
(44.1 49.1)
(52.8 57.6)
149
217
196
219
164
108
98.7
132
225
219
140
192
(127 186)
(181 285)
(175 223)
(195 237)
(149 196)
(90.3 229)
(91.3 103)
(118 156)
(200 254)
(189 250)
(126 153)
(170 219)
211
285
235
257
213
115
106
173
270
256
175
236
(186 244)
(233 357)
(222 276)
(236 305)
(179 253)
(107 238)
(101 137)
(147 214)
(237 341)
(227 328)
(151 211)
(219 277)
1,792
1,818
2,958
3,509
3,592
350
769
1,889
1,406
1,164
1,523
7,101
Geometric mean and selected percentiles of whole blood concentrations (in pmol/g Hb) for the total U.S. population aged 3 years and older,
National Health and Nutrition Examination Survey, 20032004.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
50
Females
Males
611
1219
2039
4059
60+
35
611
2039
4059
60+
4059
60+
NonHispanic Whites
50
100
150
NonHispanic Blacks
1219
Acrylamide hemoglobin
adduct (pmol/g Hb)
35
35
611
1219
2039
4059
60+
35
611
2039
Males
100
150
Females
1219
50
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Acrylamide hemoglobin
adduct (pmol/g Hb)
Mexican Americans
100
150
Overall
Acrylamide hemoglobin
adduct (pmol/g Hb)
Geometric mean (95% confidence interval), National Health and Nutrition Examination Survey, 20032004
35
611
1219
2039
Age (years)
4059
60+
35
611
1219
2039
4059
60+
Age (years)
5. Acrylamide Adducts
449
61.2
59.4
58.6
57.4
68.5
64.0
50.1
(58.1 64.4)
(53.6 65.7)
(56.1 61.2)
(54.4 60.5)
(64.1 73.3)
(59.9 68.4)
(47.9 52.3)
33.7
38.5
39.6
35.6
35.1
33.5
29.6
(32.4 35.1)
(33.3 42.9)
(37.9 42.7)
(33.8 37.1)
(32.5 37.7)
(31.9 35.3)
(27.7 31.2)
54.7
58.2
57.3
54.4
59.8
55.1
46.5
(52.8 57.6)
(52.5 64.7)
(55.1 59.6)
(52.1 57.3)
(57.0 63.9)
(52.1 59.1)
(44.1 49.1)
140
90.2
86.7
99.9
164
160
96.1
(125 155)
(83.2 108)
(81.9 93.0)
(91.0 115)
(153 195)
(142 190)
(90.2 107)
7,101
350
769
1,889
1,406
1,164
63.9
59.8
58.1
57.8
73.0
66.7
52.6
(60.2 67.9)
(53.2 67.2)
(55.2 61.1)
(53.7 62.3)
(66.9 79.7)
(62.2 71.6)
(47.8 57.9)
33.6
38.8
39.6
35.0
35.0
33.4
29.1
(31.3 35.6)
(30.3 43.5)
(35.4 41.9)
(32.0 37.2)
(30.8 38.7)
(29.3 36.0)
(27.4 31.3)
56.9
57.8
56.6
53.9
63.8
57.3
48.0
(53.6 60.0)
(49.4 65.8)
(54.7 59.3)
(51.1 57.7)
(59.3 68.6)
(51.0 64.1)
(42.9 52.8)
152
91.4
86.5
107
209
177
117
(140 177)
(82.7 115)
(81.2 91.3)
(94.6 127)
(168 228)
(150 205)
(96.9 143)
3,509
189
370
976
655
572
58.7
58.9
59.1
56.9
64.3
61.6
48.1
(55.9 61.5)
(52.9 65.5)
(56.5 61.8)
(54.5 59.5)
(60.5 68.3)
(56.6 67.0)
(46.7 49.6)
33.9
37.6
40.4
36.9
35.2
33.4
29.8
(32.7 35.1)
(22.3 43.7)
(36.7 44.2)
(33.7 37.9)
(33.0 37.5)
(32.1 35.4)
(27.2 31.7)
53.3
59.5
57.4
55.3
56.8
53.8
45.4
(51.8 55.8)
(53.1 63.3)
(55.2 60.2)
(53.0 57.7)
(54.4 59.5)
(50.2 58.9)
(44.3 46.9)
125
86.1
86.9
97.5
152
151
84.0
(112 143)
(79.4 134)
(81.0 97.5)
(87.4 109)
(131 163)
(125 186)
(77.5 93.6)
3,592
161
399
913
751
592
Males
Females
1,523
747
776
61.7
62.0
61.6
57.3
64.5
60.9
57.5
(58.7 64.9)
(57.8 66.6)
(58.2 65.3)
(53.8 61.0)
(59.9 69.5)
(55.2 67.1)
(53.9 61.4)
40.0
45.6
44.3
38.7
40.7
38.7
36.5
(38.2 42.1)
(39.5 48.1)
(40.9 45.6)
(37.4 40.1)
(38.6 42.6)
(33.8 42.2)
(31.9 38.3)
57.4
59.6
61.4
55.2
57.5
56.1
53.9
(54.4 60.3)
(56.9 65.0)
(55.9 67.0)
(51.4 59.8)
(54.6 60.4)
(48.4 63.9)
(50.0 57.9)
101
87.4
88.3
86.9
118
117
108
(95.4 115)
(78.8 104)
(84.0 96.4)
(79.6 96.5)
(96.2 191)
(91.6 153)
(91.3 120)
1,792
90
250
590
321
208
65.7
63.2
63.5
60.1
70.8
63.0
61.6
(60.9 70.9)
(57.5 69.5)
(59.7 67.6)
(55.8 64.8)
(60.5 82.9)
(57.3 69.3)
(57.0 66.5)
41.4
47.3
44.5
39.4
42.1
39.2
36.7
(38.6 43.4)
(40.5 48.8)
(40.8 48.3)
(36.8 41.5)
(37.6 44.7)
(25.0 44.2)
(32.5 38.2)
58.2
59.8
62.5
56.8
59.4
54.8
58.0
(55.0 62.6)
(57.1 65.5)
(59.6 68.1)
(53.7 61.0)
(53.2 66.6)
(50.1 59.7)
(51.6 64.0)
122
88.0
92.0
96.3
176
124
118
(103 185)
(74.1 122)
(84.2 102)
(85.5 124)
(111 353)
(92.9 193)
(101 151)
882
47
117
301
146
109
57.6
60.7
59.5
54.5
58.2
58.6
54.2
(54.8 60.6)
(55.9 65.8)
(55.3 64.1)
(50.1 59.3)
(54.6 62.0)
(51.4 66.7)
(48.2 60.9)
39.0
43.4
44.0
38.1
39.1
38.7
35.7
(36.5 40.8)
(36.4 48.5)
(39.6 45.0)
(35.0 39.7)
(34.9 41.9)
(35.6 39.6)
(19.3 40.4)
55.4
59.5
58.4
53.1
55.1
57.8
50.5
(52.0 59.4)
(49.3 68.0)
(52.3 65.7)
(47.3 60.0)
(50.8 60.9)
(45.5 66.9)
(46.3 57.3)
89.0
82.5
82.2
79.4
94.5
94.9
85.6
(82.5 96.2)
(77.2 102)
(79.6 96.2)
(72.0 93.5)
(81.1 108)
(82.2 138)
(79.3 110)
910
43
133
289
175
99
Males
Females
333
162
171
450
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
63.8
58.7
57.1
58.6
73.8
67.9
48.1
(57.1 71.2)
(53.4 64.5)
(53.6 60.8)
(53.3 64.3)
(60.9 89.4)
(59.3 77.8)
(42.3 54.6)
32.3
39.9
38.6
34.4
33.2
32.3
24.5
(30.6 33.9)
(34.1 44.1)
(33.8 41.1)
(31.6 36.7)
(29.8 37.8)
(28.5 34.5)
(21.4 26.1)
57.0
56.0
56.7
55.2
64.4
59.4
43.1
(51.9 64.0)
(53.0 62.9)
(52.3 60.4)
(52.3 58.9)
(53.5 80.8)
(49.7 69.9)
(39.3 50.7)
156
87.1
85.6
110
209
182
106
(123 210)
(74.3 156)
(77.4 97.8)
(97.5 138)
(155 293)
(152 250)
(94.7 133)
1,818
126
277
667
290
259
68.7
58.5
54.5
60.7
89.4
70.0
54.2
(60.8 77.6)
(52.4 65.4)
(51.1 58.1)
(53.5 68.9)
(72.1 111)
(59.3 82.6)
(45.8 64.2)
32.1
37.0
37.7
35.2
34.0
29.0
25.4
(29.1 34.8)
(25.8 45.7)
(31.8 40.3)
(30.8 37.2)
(29.9 40.4)
(20.9 33.2)
(21.5 28.9)
61.7
55.7
55.5
55.8
86.5
63.9
46.2
(55.2 68.2)
(52.2 65.1)
(48.5 59.4)
(50.8 63.8)
(66.6 110)
(51.4 72.9)
(40.9 61.0)
194
88.3
75.3
121
240
207
116
(140 241)
(74.7 158)
(70.6 97.3)
(102 161)
(202 361)
(158 290)
(98.5 230)
918
70
133
356
142
123
59.8
58.9
60.1
56.5
63.2
66.3
44.2
(53.4 66.8)
(52.3 66.3)
(55.2 65.4)
(52.2 61.0)
(52.5 75.9)
(57.0 77.1)
(38.2 51.2)
32.4
43.6
39.4
33.5
32.8
35.1
23.7
(30.2 34.4)
(32.2 45.3)
(35.3 43.2)
(30.4 36.7)
(27.1 37.6)
(24.1 39.3)
(19.4 26.0)
54.5
56.2
58.1
53.7
56.4
56.5
41.1
(48.3 60.5)
(48.4 67.3)
(52.1 68.0)
(51.3 57.4)
(45.3 69.7)
(47.1 71.0)
(37.8 46.9)
133
82.9
95.1
106
153
173
92.1
(106 171)
(67.1 129)
(85.5 106)
(86.0 136)
(106 290)
(147 228)
(69.4 143)
900
56
144
311
148
136
Males
Females
199
94
105
62.3
61.1
59.0
58.6
72.2
65.3
50.4
(58.9 65.9)
(51.7 72.2)
(56.2 62.0)
(55.3 62.2)
(67.6 77.0)
(60.6 70.4)
(47.9 53.0)
34.0
39.0
39.9
36.3
35.7
33.7
30.6
(32.5 35.7)
(20.8 44.7)
(35.1 44.6)
(33.3 38.5)
(31.4 39.4)
(32.1 36.1)
(28.5 31.9)
55.2
58.5
58.0
54.9
63.5
56.2
46.8
(52.9 58.5)
(47.7 78.2)
(55.2 60.3)
(52.7 57.9)
(59.2 68.5)
(52.1 61.1)
(43.9 49.7)
145
98.7
85.9
105
174
167
92.3
(130 165)
(82.6 118)
(80.4 91.5)
(95.0 120)
(157 198)
(143 206)
(84.1 113)
2,958
93
178
505
663
606
64.7
60.9
58.6
57.8
76.3
68.0
52.0
(60.6 69.0)
(49.4 75.0)
(55.5 61.9)
(53.5 62.5)
(70.4 82.8)
(62.5 74.0)
(46.7 57.8)
33.9
41.3
40.0
34.4
36.1
34.6
29.8
(31.4 36.3)
(31.0 45.6)
(30.1 46.5)
(31.7 37.0)
(30.0 41.0)
(29.3 38.0)
(27.5 31.5)
57.4
57.3
56.6
52.9
67.0
58.2
47.8
(53.1 60.9)
(44.2 82.0)
(54.7 59.1)
(50.2 57.0)
(60.9 73.8)
(50.8 66.1)
(42.4 52.5)
155
103
85.9
109
213
183
110
(141 187)
(81.4 118)
(77.4 94.8)
(94.7 134)
(166 228)
(150 213)
(87.5 136)
1,441
50
84
257
293
302
60.2
61.4
59.4
59.5
68.3
62.8
49.2
(57.0 63.5)
(51.2 73.6)
(55.7 63.4)
(56.1 63.2)
(64.0 72.9)
(56.9 69.2)
(47.8 50.6)
34.3
37.6
39.7
38.1
35.4
33.3
31.3
(32.8 35.5)
(20.8 44.2)
(28.6 44.8)
(34.4 40.4)
(30.6 39.3)
(32.2 35.2)
(29.5 33.2)
54.0
62.2
58.5
57.4
59.6
54.5
45.7
(52.1 57.1)
(47.4 75.7)
(55.3 61.2)
(54.1 59.9)
(54.7 65.8)
(50.3 60.7)
(45.0 47.4)
135
91.2
84.6
100
160
155
84.3
(119 154)
(79.5 238)
(78.2 141)
(92.2 117)
(147 182)
(129 217)
(74.6 103)
1,517
43
94
248
370
304
Males
Females
913
455
458
5. Acrylamide Adducts
451
452
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(66.9 76.7)
(70.3 78.2)
(51.1 60.1)
(61.4 68.9)
(56.8 63.5)
(42.8 48.3)
(56.9 62.3)
(56.0 62.5)
(61.2 68.4)
(50.6 56.7)
(57.6 64.9)
59.5
59.1
64.7
53.6
61.1
(56.7 62.1)
71.6
74.1
55.4
65.0
60.1
45.5
59.3
22.5
< LOD
19.6
17.8
14.3
35.3
36.8
< LOD
20.6
17.8
< LOD
17.5
(8.65 23.2)
(11.3 20.7)
(< LOD 21.4)
(27.7 37.8)
(33.0 38.6)
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Non-Hispanic Whites
Non-Hispanic Blacks
Mexican Americans
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
35 years
32.8
17.4
25.5
24.0
24.5
38.9
41.2
23.3
26.9
24.1
18.6
24.1
(25.7 36.1)
(9.74 20.9)
(23.3 26.9)
(21.5 25.7)
(19.2 27.3)
(33.4 46.3)
(36.8 44.6)
(< LOD 27.0)
(23.8 28.9)
(18.8 27.2)
(12.1 21.1)
(21.4 25.8)
65.4
55.5
60.6
59.3
60.4
71.1
75.0
59.2
64.0
58.8
46.8
59.9
(61.1 69.8)
(51.9 59.2)
(57.8 64.2)
(56.9 61.7)
(57.5 63.9)
(67.0 79.1)
(70.9 77.9)
(56.1 62.0)
(60.1 68.8)
(55.1 61.1)
(44.8 49.2)
(57.5 62.4)
152
159
172
174
158
126
140
145
195
179
129
167
(138 171)
(134 216)
(158 195)
(158 199)
(146 175)
(121 136)
(128 158)
(126 171)
(175 220)
(158 201)
(115 145)
(155 183)
199
206
213
219
197
135
157
173
244
210
163
205
(167 246)
(162 315)
(196 249)
(193 292)
(183 212)
(128 166)
(144 201)
(152 230)
(221 282)
(194 265)
(141 199)
(193 235)
1,841
1,900
3,008
3,604
3,674
411
784
1,931
1,446
1,177
1,529
7,278
Geometric mean and selected percentiles of whole blood concentrations (in pmol/g Hb) for the total U.S. population aged 3 years and older,
National Health and Nutrition Examination Survey, 20032004.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
100
Overall
50
Females
Males
611
1219
2039
4059
60+
35
611
2039
4059
60+
4059
60+
NonHispanic Whites
50
100
NonHispanic Blacks
1219
Glycidamide hemoglobin
adduct (pmol/g Hb)
35
35
611
1219
2039
4059
60+
35
611
100
Females
1219
2039
Males
50
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
Glycidamide hemoglobin
adduct (pmol/g Hb)
Mexican Americans
Glycidamide hemoglobin
adduct (pmol/g Hb)
Geometric mean (95% confidence interval), National Health and Nutrition Examination Survey, 20032004
35
611
1219
2039
Age (years)
4059
60+
35
611
1219
2039
4059
60+
Age (years)
5. Acrylamide Adducts
453
59.3
71.6
74.1
55.4
65.0
60.1
45.5
(56.7 62.1)
(66.9 76.7)
(70.3 78.2)
(51.1 60.1)
(61.4 68.9)
(56.8 63.5)
(42.8 48.3)
30.6
47.8
47.5
31.5
33.0
30.6
24.4
(28.7 32.4)
(39.0 51.4)
(43.8 49.4)
(27.3 33.8)
(29.9 35.4)
(27.7 32.8)
(22.6 25.6)
59.9
71.1
75.0
59.2
64.0
58.8
46.8
(57.5 62.4)
(67.0 79.1)
(70.9 77.9)
(56.1 62.0)
(60.1 68.8)
(55.1 61.1)
(44.8 49.2)
130
118
121
113
149
139
96.2
(120 140)
(107 126)
(113 135)
(96.8 141)
(136 167)
(124 158)
(90.6 103)
7,278
411
784
1,931
1,446
1,177
59.5
72.4
75.7
52.8
64.6
59.9
46.3
(56.9 62.3)
(67.5 77.7)
(71.8 79.9)
(48.2 57.8)
(60.9 68.6)
(56.3 63.8)
(42.8 50.1)
29.8
47.9
48.2
29.3
32.0
29.6
24.4
(27.6 32.0)
(38.4 52.2)
(45.6 50.3)
(24.5 32.7)
(28.6 33.8)
(26.1 32.8)
(22.2 25.7)
59.3
70.7
75.7
57.0
60.6
58.9
45.8
(56.9 61.7)
(66.8 76.6)
(69.9 79.6)
(53.2 61.0)
(57.6 65.9)
(54.3 62.2)
(41.6 48.6)
136
117
118
111
163
140
106
(124 148)
(99.9 145)
(112 140)
(97.5 134)
(149 174)
(128 164)
(95.4 129)
3,604
215
381
1,000
681
577
59.1
70.8
72.4
58.3
65.5
60.2
44.8
(56.0 62.5)
(63.8 78.7)
(67.2 77.9)
(52.8 64.5)
(61.4 69.8)
(55.3 65.6)
(41.8 48.1)
31.3
45.8
46.3
33.7
35.2
30.7
24.4
(29.1 33.4)
(34.1 53.1)
(43.6 48.3)
(28.7 35.7)
(31.0 38.2)
(27.8 34.3)
(21.3 26.3)
60.4
72.1
73.7
60.9
67.7
58.6
47.7
(57.5 63.9)
(65.7 82.0)
(69.6 77.9)
(56.5 65.8)
(61.4 73.7)
(53.1 64.8)
(45.2 50.8)
125
118
122
114
136
137
87.0
(116 135)
(104 130)
(106 142)
(95.9 160)
(123 160)
(115 160)
(81.1 93.8)
3,674
196
403
931
765
600
Males
Females
1,529
750
779
64.7
75.5
78.5
58.7
64.7
61.2
57.1
(61.2 68.4)
(67.6 84.3)
(72.8 84.6)
(53.3 64.5)
(58.2 72.0)
(52.8 71.0)
(53.8 60.5)
39.4
49.6
52.1
37.0
39.0
38.4
33.1
(38.4 40.5)
(40.2 55.0)
(46.5 55.3)
(32.2 40.3)
(35.1 42.2)
(17.5 41.0)
(29.3 36.1)
65.4
74.4
78.5
62.3
63.9
60.5
55.8
(61.1 69.8)
(65.9 87.3)
(76.0 81.4)
(55.8 67.0)
(59.4 70.5)
(52.9 73.0)
(50.6 61.9)
118
114
126
99.7
128
115
107
(111 130)
(103 164)
(116 140)
(93.8 115)
(108 168)
(103 144)
(97.6 117)
1,841
117
256
601
324
212
64.2
77.6
82.6
60.0
64.4
56.0
55.6
(60.0 68.7)
(67.7 89.1)
(74.3 91.7)
(52.4 68.6)
(55.9 74.2)
(47.0 66.6)
(52.4 59.0)
38.3
52.5
55.2
36.4
38.2
32.8
30.3
(33.3 39.7)
(35.6 58.5)
(48.0 60.9)
(28.3 40.4)
(29.2 40.6)
(4.98 39.7)
(17.5 35.1)
63.6
75.7
79.7
63.4
60.1
56.5
54.6
(59.3 68.4)
(68.5 87.5)
(77.4 88.6)
(56.3 68.4)
(54.5 67.4)
(49.9 62.8)
(51.7 58.5)
129
124
128
115
161
111
110
(114 160)
(101 187)
(115 161)
(91.4 159)
(107 279)
(94.7 157)
(97.4 141)
909
58
125
306
146
111
65.2
73.2
73.8
57.3
65.1
67.4
58.4
(60.7 70.0)
(63.2 84.9)
(66.6 81.8)
(52.7 62.4)
(55.1 76.8)
(57.3 79.3)
(52.1 65.5)
41.9
46.6
47.4
37.1
42.4
39.8
36.0
(39.3 44.1)
(42.6 49.5)
(43.0 52.2)
(33.5 40.9)
(28.4 46.4)
(34.4 43.6)
(27.3 39.4)
67.7
72.9
74.0
61.2
68.9
67.4
56.8
(61.8 73.7)
(58.1 88.9)
(66.4 81.5)
(54.4 67.2)
(63.2 77.5)
(54.8 81.6)
(46.6 65.2)
111
108
119
94.5
114
118
104
(106 120)
(91.8 155)
(108 144)
(88.0 102)
(104 131)
(105 156)
(87.4 124)
932
59
131
295
178
101
Males
Females
331
163
168
454
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
53.6
66.3
58.7
49.7
63.5
50.6
36.3
(50.6 56.7)
(58.9 74.6)
(54.5 63.2)
(47.0 52.5)
(56.8 71.1)
(45.2 56.7)
(32.9 40.1)
27.1
41.3
35.8
27.0
33.4
23.5
15.4
54.8
65.8
59.5
48.5
71.1
46.9
38.8
(49.8 60.4)
(54.8 79.0)
(53.9 65.7)
(44.4 53.0)
(60.0 84.3)
(39.1 56.2)
(34.7 43.3)
52.5
66.9
57.9
50.8
58.0
53.9
34.7
(49.6 55.5)
(60.4 74.1)
(49.9 67.1)
(47.2 54.7)
(51.8 64.9)
(49.1 59.1)
(29.2 41.2)
Males
Females
(24.4 29.8)
(26.9 48.6)
(27.2 41.1)
(24.8 29.3)
(26.9 35.7)
(17.5 29.4)
(10.4 19.4)
55.5
70.0
63.0
52.6
63.7
50.9
39.7
(51.9 59.2)
(58.0 79.8)
(57.3 69.2)
(49.5 56.1)
(55.8 73.8)
(46.2 56.4)
(36.6 42.9)
121
101
108
106
144
133
84.6
(110 142)
(96.2 112)
(96.7 126)
(87.7 124)
(120 228)
(95.3 186)
(79.9 98.7)
1,900
141
282
690
311
265
26.5
40.1
35.7
25.3
33.3
17.5
19.9
(23.5 28.6)
(< LOD 49.0)
(4.48 43.5)
(21.2 27.8)
(27.7 36.6)
(4.35 20.9)
(9.71 22.2)
56.4
70.8
62.9
51.0
70.1
50.3
41.2
(52.2 61.8)
(54.1 84.2)
(54.4 68.5)
(46.6 56.0)
(57.1 83.5)
(43.7 56.6)
(33.6 47.1)
134
100
108
113
152
156
81.8
(114 162)
(95.0 130)
(92.6 141)
(90.4 141)
(121 309)
(101 207)
(74.1 120)
956
77
133
369
154
124
28.0
40.4
35.7
30.7
33.3
29.8
14.1
(22.2 32.1)
(30.2 55.7)
(< LOD 41.3)
(24.9 33.1)
(< LOD 35.7)
(22.5 33.3)
(< LOD 19.4)
55.0
68.3
63.5
54.1
60.3
50.9
38.7
(50.3 60.1)
(58.2 79.8)
(54.0 74.1)
(50.7 57.8)
(52.6 69.8)
(46.1 57.8)
(34.4 42.9)
114
100
106
98.7
130
115
87.3
(101 132)
(89.7 109)
(96.3 120)
(83.2 122)
(111 183)
(90.7 169)
(74.8 103)
944
64
149
321
157
141
211
99
112
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
61.1
75.5
78.5
57.9
68.5
62.8
46.6
(57.6 64.9)
(67.8 84.1)
(73.8 83.6)
(52.8 63.5)
(63.9 73.5)
(58.4 67.5)
(43.1 50.5)
31.1
50.7
51.3
33.4
32.9
31.9
25.0
(28.9 32.8)
(37.9 53.7)
(43.2 55.7)
(27.6 34.9)
(29.7 37.3)
(29.1 34.2)
(23.3 26.6)
60.6
72.3
76.0
60.4
67.5
60.4
47.7
(57.8 64.2)
(65.8 88.4)
(74.1 79.5)
(57.1 62.9)
(61.1 72.9)
(56.8 64.4)
(45.1 50.9)
135
121
123
115
160
143
96.7
(124 149)
(114 133)
(109 150)
(97.9 148)
(142 176)
(129 164)
(89.9 106)
3,008
110
183
512
682
610
61.0
74.2
79.8
54.4
66.7
63.7
46.9
(57.6 64.6)
(66.5 82.7)
(74.8 85.1)
(48.8 60.7)
(62.4 71.3)
(58.1 69.8)
(42.4 51.7)
30.2
48.0
55.5
30.4
31.9
32.3
24.5
(28.2 32.5)
(37.9 55.0)
(47.5 57.9)
(24.0 34.3)
(28.5 35.3)
(26.5 35.6)
(21.1 26.4)
60.1
68.7
75.8
57.3
62.9
60.6
45.9
(57.3 62.8)
(60.3 88.3)
(70.9 84.9)
(53.2 60.5)
(58.3 67.8)
(56.6 64.6)
(41.5 49.1)
140
118
116
102
170
141
106
(125 155)
(98.8 195)
(108 156)
(93.6 143)
(154 182)
(129 168)
(95.5 128)
1,473
58
87
264
308
303
61.2
77.1
77.2
62.0
70.5
61.9
46.5
(57.1 65.7)
(66.0 90.1)
(70.7 84.2)
(54.9 70.0)
(64.4 77.1)
(55.7 68.9)
(42.7 50.6)
31.7
51.9
48.7
34.4
36.5
30.9
25.7
(29.1 34.3)
(< LOD 60.9)
(39.3 53.1)
(27.2 41.5)
(28.0 42.6)
(27.7 35.5)
(23.9 26.9)
61.1
78.6
76.6
63.0
71.2
60.0
49.3
(57.9 65.8)
(62.4 100)
(71.9 80.3)
(57.9 69.5)
(63.9 78.3)
(54.1 68.0)
(46.3 51.5)
132
124
125
119
142
144
87.1
(120 147)
(101 135)
(99.1 197)
(99.0 168)
(130 191)
(116 182)
(80.4 97.9)
1,535
52
96
248
374
307
Males
Females
911
453
458
< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
5. Acrylamide Adducts
455
456
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
(1.18 1.32)
(1.20 1.30)
(.889 1.02)
(.896 .985)
(.883 .970)
(.855 .948)
(.886 .951)
(.956 1.04)
(.987 1.11)
(.762 .904)
(.932 1.00)
.918
.999
1.05
.830
.967
(.923 .995)
1.25
1.25
.952
.939
.926
.900
.958
.513
.098
< LOD
.410
.402
.715
.691
< LOD
.419
.400
< LOD
.406
(.313 .470)
(< LOD .493)
(.097 .835)
(.555 .772)
.616
.397
.548
.514
.566
.836
.807
.560
.537
.507
.475
.529
(.554 .684)
(.141 .447)
(.507 .591)
(.487 .537)
(.464 .622)
(.435 .881)
(.700 .852)
(< LOD .625)
(.474 .585)
(.466 .540)
(.359 .528)
(.489 .562)
1.09
.893
1.01
.955
1.06
1.28
1.28
1.01
.988
.974
.961
1.01
(1.03 1.16)
(.845 .949)
(.984 1.03)
(.926 .990)
(1.02 1.09)
(1.23 1.38)
(1.23 1.33)
(.987 1.04)
(.939 1.03)
(.935 1.01)
(.928 .984)
(.984 1.03)
1.73
1.62
1.63
1.58
1.72
1.77
2.02
1.72
1.62
1.58
1.57
1.65
< LOD means less than the limit of detection for either the whole blood acrylamide adduct or the glycidamide adduct, which may vary for some compounds by year. See Appendix D for LOD.
Non-Hispanic Whites
Non-Hispanic Blacks
Mexican Americans
Race/ethnicity
Males
Females
Gender
611 years
1219 years
2039 years
4059 years
60 years and older
35 years
(1.60 2.17)
(1.46 1.96)
(1.54 1.80)
(1.52 1.69)
(1.62 1.93)
(1.64 2.02)
(1.88 2.47)
(1.52 2.47)
(1.53 1.77)
(1.49 1.76)
(1.48 1.73)
(1.57 1.81)
1.99
1.82
1.85
1.79
1.97
2.00
2.51
2.14
1.84
1.75
1.78
1.88
(1.77 2.57)
(1.64 2.94)
(1.71 2.18)
(1.66 2.09)
(1.79 2.59)
(1.73 2.30)
(2.02 4.24)
(1.72 3.88)
(1.66 2.19)
(1.63 2.42)
(1.63 2.34)
(1.75 2.21)
1,739
1,736
2,859
3,389
3,455
336
742
1,817
1,364
1,124
1,461
6,844
Geometric mean and selected percentiles of ratio (no units) of whole blood concentrations (in pmol/g Hb) for the total U.S. population aged 3
years and older, National Health and Nutrition Examination Survey, 20032004.
Selected percentiles (95% conf. interval)
Geometric mean
Sample
2.5th
5th
50th
95th
97.5th
( 95% conf. interval)
size
Mexican Americans
1.5
2.0
Overall
0.0
0.5
1.0
Females
Males
35
611
1219
2039
4059
60+
35
611
2039
4059
60+
4059
60+
NonHispanic Whites
0.0
0.5
1.0
1.5
2.0
NonHispanic Blacks
1219
35
611
1219
2039
4059
60+
35
611
2039
Males
1.5
2.0
Females
1219
0.5
1.0
Mexican
Americans
NonHispanic
Blacks
NonHispanic
Whites
0.0
Glycidamidetoacrylamide
hemoglobin adduct ratio
Glycidamidetoacrylamide
hemoglobin adduct ratio
Glycidamidetoacrylamide
hemoglobin adduct ratio
Geometric mean (95% confidence interval), National Health and Nutrition Examination Survey, 20032004
35
611
1219
2039
Age (years)
4059
60+
35
611
1219
2039
4059
60+
Age (years)
5. Acrylamide Adducts
457
.958
1.25
1.25
.952
.939
.926
.900
(.923 .995)
(1.18 1.32)
(1.20 1.30)
(.889 1.02)
(.896 .985)
(.883 .970)
(.855 .948)
.642
.944
.899
.670
.643
.618
.607
(.620 .661)
(.647 1.05)
(.853 .923)
(.609 .719)
(.606 .668)
(.561 .643)
(.550 .649)
1.01
1.28
1.28
1.01
.988
.974
.961
(.984 1.03)
(1.23 1.38)
(1.23 1.33)
(.987 1.04)
(.939 1.03)
(.935 1.01)
(.928 .984)
1.48
1.61
1.72
1.45
1.43
1.41
1.39
(1.42 1.54)
(1.57 1.78)
(1.61 1.96)
(1.37 1.62)
(1.38 1.51)
(1.36 1.51)
(1.32 1.49)
6,844
336
742
1,817
1,364
1,124
.918
1.25
1.28
.908
.874
.883
.865
(.886 .951)
(1.16 1.35)
(1.22 1.35)
(.842 .980)
(.832 .918)
(.848 .920)
(.823 .908)
.610
.863
.899
.651
.607
.573
.558
(.585 .632)
(.621 1.06)
(.846 .983)
(.599 .677)
(.562 .641)
(.537 .618)
(.508 .629)
.955
1.26
1.31
.984
.895
.933
.905
(.926 .990)
(1.22 1.38)
(1.22 1.39)
(.952 1.01)
(.862 .939)
(.895 .979)
(.860 .943)
1.41
1.60
1.72
1.38
1.25
1.34
1.35
(1.35 1.49)
(1.54 1.86)
(1.66 1.97)
(1.34 1.47)
(1.20 1.34)
(1.23 1.49)
(1.26 1.47)
3,389
181
359
944
638
549
.999
1.25
1.22
1.00
1.01
.967
.929
(.956 1.04)
(1.17 1.34)
(1.15 1.29)
(.928 1.08)
(.958 1.07)
(.904 1.03)
(.865 .998)
.679
.971
.898
.730
.690
.639
.647
(.641 .711)
(.811 1.04)
(.833 .923)
(.635 .776)
(.651 .701)
(.563 .706)
(.534 .710)
1.06
1.29
1.27
1.04
1.08
1.01
.998
(1.02 1.09)
(1.22 1.45)
(1.20 1.29)
(1.00 1.10)
(1.02 1.13)
(.957 1.07)
(.969 1.04)
1.52
1.64
1.71
1.57
1.55
1.47
1.41
(1.47 1.61)
(1.51 2.07)
(1.58 2.00)
(1.41 1.84)
(1.47 1.70)
(1.39 1.59)
(1.35 1.52)
3,455
155
383
873
726
575
Males
Females
1,461
718
743
1.05
1.32
1.27
1.03
.997
.999
.989
(.987 1.11)
(1.26 1.40)
(1.17 1.37)
(.965 1.09)
(.904 1.10)
(.918 1.09)
(.908 1.08)
.748
1.06
.953
.767
.689
.718
.716
(.697 .780)
(.957 1.11)
(.923 .989)
(.717 .822)
(.608 .755)
(.616 .772)
(.561 .774)
1.09
1.33
1.25
1.05
1.06
1.04
.996
(1.03 1.16)
(1.25 1.41)
(1.19 1.34)
(.999 1.12)
(.972 1.14)
(.988 1.12)
(.936 1.05)
1.57
1.59
1.76
1.50
1.56
1.51
1.38
(1.46 1.75)
(1.54 1.88)
(1.57 2.53)
(1.42 1.73)
(1.42 1.77)
(1.36 2.60)
(1.28 1.62)
1,739
89
244
568
312
202
.977
1.35
1.29
.996
.907
.886
.906
(.916 1.04)
(1.25 1.46)
(1.16 1.44)
(.880 1.13)
(.823 1.00)
(.775 1.01)
(.820 1.00)
.689
1.09
.984
.750
.660
.611
.642
(.616 .722)
(1.02 1.15)
(.102 1.06)
(.602 .813)
(.532 .708)
(.197 .722)
(.087 .750)
1.01
1.33
1.26
1.03
.930
.946
.937
(.949 1.07)
(1.14 1.54)
(1.19 1.38)
(.948 1.12)
(.877 1.02)
(.872 1.01)
(.877 1.00)
1.52
1.60
1.85
1.49
1.39
1.34
1.28
(1.41 1.60)
(1.55 1.95)
(1.57 4.24)
(1.42 1.67)
(1.19 1.64)
(1.24 1.60)
(1.23 1.36)
858
46
117
290
141
106
1.12
1.30
1.23
1.06
1.10
1.14
1.07
(1.06 1.19)
(1.22 1.38)
(1.10 1.38)
(1.01 1.11)
(.980 1.24)
(1.04 1.25)
(.919 1.24)
.847
.993
.926
.820
.871
.823
.777
(.801 .890)
(.905 1.11)
(.860 .977)
(.716 .870)
(.658 .936)
(.754 .889)
(.486 .881)
1.17
1.32
1.25
1.08
1.17
1.16
1.05
(1.10 1.25)
(1.25 1.40)
(1.16 1.33)
(1.02 1.16)
(1.10 1.27)
(1.04 1.36)
(.881 1.28)
1.62
1.58
1.68
1.54
1.70
1.54
1.48
(1.49 1.96)
(1.45 1.76)
(1.57 1.95)
(1.39 2.11)
(1.50 2.10)
(1.43 2.60)
(1.32 3.87)
881
43
127
278
171
96
Males
Females
324
158
166
458
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
.830
1.15
1.02
.834
.865
.720
.752
(.762 .904)
(1.08 1.23)
(.927 1.13)
(.752 .925)
(.768 .975)
(.642 .807)
(.652 .868)
.526
.865
.708
.582
.547
.427
.458
.782
1.17
1.10
.770
.797
.628
.717
(.721 .847)
(1.10 1.24)
(.985 1.23)
(.666 .890)
(.739 .860)
(.532 .741)
(.592 .869)
.875
1.14
.947
.905
.924
.802
.778
(.788 .972)
(1.02 1.27)
(.807 1.11)
(.815 1.00)
(.778 1.10)
(.728 .885)
(.643 .941)
Males
Females
(.440 .588)
(.697 .961)
(.563 .793)
(.484 .635)
(.424 .604)
(.340 .509)
(.184 .542)
.893
1.15
1.10
.893
.900
.805
.822
(.845 .949)
(1.07 1.24)
(1.00 1.20)
(.858 .931)
(.827 .974)
(.746 .874)
(.743 .915)
1.39
1.53
1.74
1.38
1.39
1.19
1.24
(1.27 1.60)
(1.37 1.83)
(1.58 1.92)
(1.26 1.66)
(1.24 1.64)
(1.11 1.35)
(1.15 1.62)
1,736
122
265
637
277
248
.512
.940
.711
.554
.490
.413
.457
(.429 .546)
(< LOD .985)
(.560 .831)
(.420 .613)
(.431 .537)
(.073 .483)
(.046 .565)
.830
1.14
1.12
.833
.808
.727
.766
(.784 .878)
(1.08 1.24)
(1.02 1.20)
(.808 .859)
(.741 .880)
(.643 .809)
(.691 .853)
1.31
1.57
1.78
1.30
1.18
1.11
1.15
(1.20 1.53)
(1.39 1.82)
(1.66 2.11)
(1.12 1.64)
(1.06 1.77)
(1.02 1.24)
(1.02 2.25)
875
68
126
341
136
115
.581
.792
.690
.603
.602
.463
.425
(.412 .643)
(.716 .967)
(< LOD .784)
(.447 .701)
(< LOD .726)
(.380 .602)
(< LOD .574)
.951
1.16
1.08
.983
.974
.870
.831
(.885 1.00)
(1.03 1.26)
(.955 1.21)
(.921 1.05)
(.885 1.12)
(.805 .926)
(.766 1.00)
1.42
1.48
1.55
1.44
1.52
1.24
1.32
(1.31 1.62)
(1.32 2.00)
(1.32 2.11)
(1.31 1.82)
(1.36 1.89)
(1.15 1.48)
(1.15 3.57)
861
54
139
296
141
133
187
89
98
< LOD means less than the limit of detection for either the whole blood acrylamide adduct or the glycidamide adduct, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
5. Acrylamide Adducts
459
.967
1.28
1.31
.979
.939
.948
.914
(.932 1.00)
(1.15 1.43)
(1.23 1.38)
(.901 1.06)
(.896 .984)
(.910 .988)
(.859 .972)
.651
.863
.939
.699
.645
.629
.631
(.629 .675)
(.097 1.18)
(.852 .989)
(.642 .748)
(.610 .678)
(.591 .658)
(.553 .669)
1.01
1.32
1.32
1.02
.984
.986
.966
(.984 1.03)
(1.23 1.47)
(1.27 1.38)
(.981 1.07)
(.924 1.02)
(.954 1.02)
(.935 .989)
1.47
1.61
1.72
1.42
1.42
1.41
1.40
(1.41 1.53)
(1.56 2.05)
(1.55 2.41)
(1.36 1.61)
(1.37 1.51)
(1.34 1.50)
(1.33 1.55)
2,859
89
172
490
648
586
.927
1.24
1.32
.947
.862
.922
.880
(.898 .958)
(1.07 1.43)
(1.24 1.41)
(.862 1.04)
(.820 .905)
(.891 .954)
(.835 .929)
.627
.842
.944
.669
.609
.619
.570
(.605 .649)
(.621 1.10)
(.748 1.03)
(.609 .722)
(.549 .644)
(.557 .649)
(.512 .636)
.955
1.27
1.33
1.01
.886
.945
.922
(.922 .993)
(1.10 1.46)
(1.27 1.42)
(.940 1.04)
(.852 .930)
(.910 .987)
(.862 .953)
1.39
1.57
1.70
1.37
1.24
1.33
1.38
(1.33 1.48)
(1.48 2.06)
(1.57 2.25)
(1.32 1.41)
(1.20 1.30)
(1.23 1.44)
(1.27 1.49)
1,400
48
82
254
289
291
1.01
1.33
1.29
1.02
1.02
.975
.942
(.961 1.05)
(1.17 1.51)
(1.19 1.40)
(.929 1.11)
(.954 1.10)
(.899 1.06)
(.866 1.02)
.681
1.01
.923
.743
.691
.639
.658
(.648 .706)
(< LOD 1.19)
(.777 .995)
(.636 .786)
(.654 .700)
(.513 .736)
(.528 .724)
1.06
1.46
1.28
1.05
1.06
1.02
1.00
(1.02 1.09)
(1.26 1.48)
(1.20 1.39)
(.996 1.13)
(1.00 1.14)
(.969 1.08)
(.968 1.05)
1.52
1.72
1.79
1.57
1.55
1.43
1.43
(1.45 1.62)
(1.51 2.09)
(1.54 2.97)
(1.37 1.87)
(1.46 1.77)
(1.38 1.63)
(1.35 1.56)
1,459
41
90
236
359
295
Males
Females
874
436
438
< LOD means less than the limit of detection for either the whole blood acrylamide adduct or the glycidamide adduct, which may vary for some compounds by year. See Appendix D for LOD.
Estimate is subject to greater uncertainty due to small cell size.
460
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
References
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Hogervorst JG, Baars BJ, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA. The carcinogenicity of dietary
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Smith J, Perfetty TA, Rumple MA, Rodgam A, Doolittle D. IARC group 2A carcinogens reported in cigarette
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Vesper HW, Bernert JT, Ospina M, Meyers T, Ingham L, Smith A, et al. Assessment of the relation between biomarkers for
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5. Acrylamide Adducts
461
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2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Appendices
Appendix A
Appendix B
Appendix C
Appendix D
Appendix E
Appendix F
Appendix G
Appendices
465
Appendix A
NHANES Reports Related to Nutritional Status
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Levels: The Latest NHANES Results. NCHS Data Brief, No 6. Hyattsville, MD: National
Center for Health Statistics. 2008.
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Fulwood R, Johnson CL, Bryner JD, Gunter EW, McGrath CR. Hematological and nutritional
biochemistry reference data for persons 6 months74 years of age: United States, 19761980.
National Center for Health Statistics. Vital Health Stat Series No. 11(232), 1982.
Appendices
467
468
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
2003-2004
2003-2006
Serum 25-hydroxyvitamin D
Fatty Acids - Saturated
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
Serum gamma-tocopherol
Serum alpha-carotene
Serum trans-beta-carotene
Serum cis-beta-carotene
Serum beta-cryptoxanthin
Serum lutein and zeaxanthin
Serum trans-lycopene
Serum total lycopene
2005-2006
2005-2006
2005-2006
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2006
2005-2006
2005-2006
2005-2006
not shown*
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
not shown*
2005-2006
2005-2006
20032006
20032006
2005-2006
20032006
20032006
20052006
20052006
20032006
20032006
20032004
Figure:
Concentrations
by age group
20032006
20032006
20052006
20052006
20032006
20032006
20032004
Serum vitamin A
Serum vitamin C
Serum folate
Red blood cell folate
Serum pyridoxal-5-phosphate
Serum 4-pyridoxic acid
Serum vitamin B12
Plasma homocysteine
Plasma methylmalonic acid
Water-Soluble Vitamins
Indicator
Table:
Concentrations
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
2005-2006
20032006
20032006
20032006
20052006
20052006
20032006
20032006
20032004
Tables:
Concentrations
by race/ethnic
group
none
none
none
none
none
none
2001-2006
1999-2002; 2005-2006
2001-2002; 2005-2006
2001-2002; 2005-2006
2001-2002; 2005-2006
2001-2002; 2005-2006
2001-2002; 2005-2006
2001-2002; 2005-2006
none
none
none
1999-2002; 2005-2006
1999-2002; 2005-2006
20032006
19992006
19992006
none
none
19992006
19992006
19992004
none/none
none/none
none/none
none/none
none/none
none/none
2003-2006/2003-2006
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
2005-2006/not shown*
2005-2006/2005-2006
20032006/none
not shown*/none
20032006/none
20052006/none
none/none
20032006/none
20032006/none
20032004/none
Table(s):
Prevalence
(Deficiency/Excess)
The table below provides information on the type of data included for each indicator and the years of NHANES covered.
Appendix B
Information Presented in the Report
none/none
none/none
none/none
none/none
none/none
none/none
2001-2006/2001-2006
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
1999-2002; 2005-2006/
not shown*
1999-2002; 2005-2006/
1999-2002; 2005-2006
20032006/none
not shown*/none
19992006/none
none/none
none/none
19992006/none
19992006/none
19992004/none
Table(s):
Prevalence by
survey cycle
(Deficiency/Excess)
Appendices
469
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
Urinary enterolactone
2003-2004
2003-2004
Glycidamide-to-acrylamide hemoglobin
adduct ratio
2003-2004
2003-2004
2003-2004
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
Figure:
Concentrations
by age group
2003-2004
2003-2004
2003-2004
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2006
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
Tables:
Concentrations
by race/ethnic
group
* Prevalence table is not shown if most or all estimates have been suppressed because of the RSE being 40%.
2003-2004
2003-2006
Urinary daidzein
Urinary equol
Urinary O-desmethylangolensin
Urinary enterodiol
2003-2006
2003-2006
2003-2006
2003-2006
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
2003-2004
Urinary genistein
Urinary iodine
Serum ferritin
Serum soluble transferrin receptor
Body iron
Iron-Status Indicators
Trace Elements
Indicator
Table:
Concentrations
none
none
none
1999-2006
1999-2006
1999-2006
1999-2006
1999-2006
1999-2006
2001-2006
1999-2006
2003-2006
2003-2006
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
2003-2006/ 2003-2006
2003-2006/none
2003-2006/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
Table(s):
Prevalence
(Deficiency/Excess)
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
1999-2006/1999-2006
2003-2006/none
2003-2006/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
none/none
Table(s):
Prevalence by
survey cycle
(Deficiency/Excess)
Appendix C
Cutoff Points used to Generate Prevalence Estimates
The table below presents the cutoff values used to calculate prevalence estimates of low or high
concentrations of biochemical indicators for various population groups and the years for which
NHANES data were available. The clinical interpretation of the cutoff values is described in the
text that accompanies each chapter.
Indicator
Units
Cutoff value
Population described
Serum folate
ng/mL
<2
3 years
19992002
1 years
20032006
ng/mL
< 95
3 years
19992002
1 years
20032006
Water-Soluble Vitamins
Serum pyridoxal-5-phosphate
nmol/L
< 20
1 years
20052006
pg/mL
< 200
3 years
19992002
1 years
20032006
Plasma homocysteine
mol/L
> 13
3 years
19992004
20 years
20052006
nmol/L
> 271
3 years
19992004
Serum vitamin C
mol/L
< 11.4
6 years
20032006
g/dL
< 20
6 years
19992002; 20052006
g/dL
> 100
6 years
19992002; 20052006
g/dL
< 500
6 years
19992002; 20052006
g/dL
> 20,000
6 years
19992002; 20052006
nmol/L
< 30
6 years or 1 year*
20012006
nmol/L
30< 50
6 years or 1 year*
20012006
nmol/L
< 40
6 years or 1 year*
20012006
nmol/L
> 125
6 years or 1 year*
20012006
ng/mL
< 12
1-5 years
19992006
ng/mL
< 15
19992006
ng/mL
< 15
Males 6 years
19992002
ng/mL
> 150
19992006
ng/mL
> 200
Males 12 years
19992002
Fat-Soluble Vitamins
Serum vitamin A
Serum vitamin E
Serum 25-hydroxyvitamin D
Iron-Status Indicators
Serum ferritin
mg/L
> 4.4
20032006
Body iron
mg/kg
<0
1-5 years
20032006
mg/kg
<0
20032006
470
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Appendix D
References for Analytical Methods for Biochemical
Indicators
Detailed Laboratory Procedure Manuals for Each Analytical Method:
NHANES 20032004: http://www.cdc.gov/nchs/nhanes/nhanes2003-2004/lab_
methods_03_04.htm.
NHANES 20052006: http://www.cdc.gov/nchs/nhanes/nhanes2005-2006/lab_
methods_05_06.htm.
Appendices
471
Trace Elements
Looker AC, Gunter EW, Johnson CL. Methods to assess iron status in various NHANES surveys. Nutr Rev.
1995;53:246254.
Pfeiffer CM, Cook JD, Mei Z, Cogswell ME, Looker AC, Lacher DA. Evaluation of an automated soluble
transferrin receptor (sTfR) assay on the Roche Hitachi analyzer and its comparison to two ELISA assays. Clin
Chim Acta 2007;382:112116.
Caldwell KL, Maxwell CB, Makhmudov A, Pino S, Braverman LE, Jones RL, et al. Use of inductively coupled
plasma mass spectrometry to measure urinary iodine in NHANES 2000: comparison with previous method. Clin
Chem. 2003;49:10191021.
472
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Appendix E
Confidence Interval Estimation for Percentiles
A large body of literature describes various methods to estimate percentiles and to derive the
variance and confidence intervals for complex survey data. Highlighted in the literature are the
following methods: Woodruff method (Woodruff 1952), test inversion method (Francisco and
Fuller 1991), the Normal transformation method (Korn and Graubard 1999), and Replication
methods (Kovar 1988, Rogers 2003).
Confidence intervals for percentiles in this report were calculated with the Woodruff method.
This method uses the standard error of the empirical distribution function at the selected
percentile and constructs a 95% confidence interval, followed by back transformation using the
inverse of the empirical distribution. The previous National Report on Biochemical Indicators
of Diet and Nutrition in the U.S. Population, 19992002 used a variation of the Woodruff
method by combining it with the method of Clopper and Pearson proposed by Korn and
Graubard (1999) for complex surveys. This approach was used previously because large-sample
normal approximations used to calculate confidence intervals for proportions close to zero or
1 can lead to confidence intervals with poor coverage properties. However, a paper by Sitter
and Wu (2001) concluded that despite the fact that confidence intervals around the empirical
distribution function at tail regions perform poorly, the Woodruff confidence intervals obtained
by inverting these poorly behaved intervals perform very well for percentiles. Therefore, the
confidence intervals presented in this report are based on the Woodruff approach with no further
modifications, as described in the steps below.
Background
Define an arbitrary percentile Xp, such that F(X) = P(X Xp) = p. This is pictured in Figure
1, where the y-axis displays the empirical distribution function (cdf ) over a set of hypothetical
values. In this example, p = 0.5 and so X0.5 is the median. Both SAS (version 9.2) and SUDAAN
(version 10.0) find Xp through linear interpolation. Let F (xj) be an estimate of the empirical
distribution function at x and assume data x1, x2, xn are a rank ordered listing of the sampled
values, such that x1 is the minimum value and xn is the maximum value; then the estimated
percentile by use of linear interpolation is calculated as:
x
X
p
j
p F( x j )
x j1 x j
F( x j 1 ) F( x j )
F( x j ) p F( x j 1 ).
To find the percentiles and confidence intervals in this report, we used results derived from
SUDAANs PROC DESCRIPT (DESIGN=WR) PERCENTILE statement and results from the
Histogram output group.
Appendices
473
XP
Analyte Value
Step 1
Use SUDAAN (DESIGN=WR) to estimate the percentiles, the empirical distribution, and the
standard error of the empirical distribution function at each point. SUDAAN uses a HorowitzThompson estimator of the empirical distribution function at each value. The estimated
empirical distribution function can be outputted into a dataset using the HISTPCT statement in
conjunction with an OUTPUT statement in PROC DESCRIPT. By default, SUDAAN estimates
the empirical distribution function by using a maximum of 100 equally spaced percentages to
divide the population into bins. We used the option /NPCT in the HISTPCT statement to
change this default to allow a jump in the empirical distribution function at every unique data
value, up to 2950 unique values. An output file is generated by SUDAAN to contain: the upper
endpoint of the current bin in the histogram, the cumulative percent less than or equal to the
upper endpoint of the current bin and the respective estimated standard error of the cumulative
percent. This file is used to obtain 95% confidence intervals of the empirical distribution function
at the selected percentile. In some rare cases, using the values of the upper endpoint available in
this file may differ slightly from a rank order list of the weighted sampled values if there are more
than 2950 distinct values. This difference may lead to very small differences when comparing the
confidence limits to other software which uses Woodruff confidence limits based on the weighted
sample values. Sample SUDAAN code for serum folate (FOL) is as follows:
474
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
WEIGHT WTMEC4YR;
VAR LBXFOL;
PERCENTILES 5 10 90 95 /MEDIAN ;
HISPCT /NPCT=2950;
FILETYPE=SAS REPLACE ;
OUTPUT UPPEREND CUMPCT SECUMPCT /FILENAME=HIST FILETYPE=SAS
REPLACE;
If you change the first OUTPUT statement in the above program to
OUTPUT QTILE LOWQTILE UPQTILE /FILENAME=PCTILES FILETYPE=SAS
REPLACE ;
SUDAAN will provide the upper and lower confidence limits based on the test inversion
method of Francisco and Fuller. However, as mentioned earlier, this report does not use
SUDAANs default method to generate confidence intervals for percentiles.
Step 2
Using SAS DATA steps to manipulate the output files from Step 1, find the value of the estimated
cumulative distribution function that is less than or equal to p using the values of the cumulative
percent produced by SUDAAN in the output file HIST:
Save F (xj) and the corresponding standard error (SE) estimate at F (xj) and proceed to step 3.
F( x j ) p F( x j1 )
Step 3
Using p (the desired percentile) and the standard error of the estimate of F (xj), compute the
95% confidence interval for p: (pL, pU) as p+t0.025,DFSE, where the degrees of freedom (DF) are
the number of primary sampling units minus the number of strata and SE is the standard error
from step 2. To get the appropriate degrees of freedom for each subgroup use the ATLEVEL1 and
ATLEVEL2 options in SUDAANs PROC DESCRIPT to count up the number of strata and
PSUs with valid data. This must be done in a separate call to PROC DESCRIPT than the one
that calculates the percentiles because the HISTPCT statement is not available with ATLEVEL.
Note: SAS (version 9.2) uses the empirical point estimate at the desired percentile, p = F (xj), in
order to calculate the 95% confidence interval as p +t0.025,DFSE.
Appendices
475
Step 4
Map the lower (pL) and upper (pU) confidence intervals of the empirical distribution function at
the desired percentile using the inverse of the empirical distribution function (see Figure 2) and
linear interpolation to get the confidence interval for the percentile of interest.
be the upper confidence
be the lower confidence limit of the estimated percentile and U
Let L
p
p
limit of the estimated percentile. x1, x2, xn are a rank ordered listing of the values as produced
by SUDAAN using HISTPCT, such that x1 is the minimum value and xn is the maximum value;
then these can be found from the following expressions:
x1
p L F( x j )
x x j
L p x j
( x ) F( x ) j1
F
j1
j
xn
p L F( x 1 )
F( x j ) p L F( x j1 )
pL 1
x1
p U F( x j )
x j1 x j
Up x j
F
(
x
)
F
(
x
)
j 1
j
xn
p U F( x 1 )
F( x j ) p U F( x j1 )
pU 1
Figure
2
pU
p
pL
Lp
Xp
Up
AnalyteValue
476
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Commercial Software
PROC DESRIPT in SUDAAN (version 8.0 and higher) calculates confidence limits for the
percentiles using the test-inversion method by Fransisco and Fuller, as noted in Step 1.
PROC SURVEYMEANS (SAS version 9.1 and higher) can be used to obtain Woodruff like
confidence intervals for percentiles. However, the SURVEYMEANS method differs slightly from
the traditional Woodruff method as noted in Step 3.
References
Francisco CA, Fuller WA. Quantile estimation with a complex survey design. Annals Statist. 1991;19:454469.
Korn EL, Graubard BI. Analysis of Health Surveys. Wiley: New York, 1999.
Kovar JG, Rao JNK, Wu CFL. Bootstrap and other methods to measure errors in survey estimated. Can J Statist.
1988;16S:2545.
Research Triangle Institute (2008). SUDAAN Language Manual, Release 10.0 Research Triangle Park, NC: Research
Triangle Institute.
Rogers JW. Estimating the variance of percentiles using replicate weights. Proceedings of the Section on Survey
Research Methods. 2003.
Sitter RR, Wu C. A note on Woodruff confidence intervals for quantiles. Statist Probabil Letters. 2001;52:353358.
Woodruff RS. Confidence intervals for medians and other position measures. J Am Statist Assoc. 1952;57:622627.
U.S. Centers for Disease Control and Prevention. NHANES Analytic guidelines, the Third National Health and
Nutrition Examination Survey, NHANES III (198894). Hyattsville (MD): National Center for Health Statistics;
October 1996 [cited 2008]. Available from: http://www.cdc.gov/nchs/data/nhanes/nhanes3/nh3gui.pdf.
Appendices
477
Appendix F
Limit of Detection Table
The table below presents the analytical limit of detection (LOD) for each indicator. The LOD is the level at
which the measurement has a 95 percent probability of being greater than zero (Taylor 1987). For the same
indicator, LOD values may change over time as a result of changes to analytical methods. This was the case
for serum ferritin and urinary phytoestrogens. We used the highest LOD value when multi-year data were
combined. The information provided in parentheses specifies what proportion of results was below the LOD
for each indicator and survey cycle.
Indicator
Units
1999-2000
2001-2002
2003-2004
2005-2006
Serum folate
ng/mL
0.1 (0%)
0.1 (0%)
0.1 (0%)
0.1 (0%)
ng/mL
20 (0%)
20 (0%)
20 (< 1%)
20 (0%)
Serum pyridoxal-5-phosphate
nmol/L
no data
no data
no data
0.3 (0%)
nmol/L
no data
no data
no data
0.3 (0%)
pg/mL
20 (0%)
20 (0%)
20 (0%)
20 (0%)
Plasma homocysteine
mol/L
0.35 (0%)
0.35 (0%)
0.35 (0%)
0.35 (0%)
nmol/L
50 (1%)
50 (1%)
50 (< 1%)
no data
mol/L
no data
no data
g/dL
1.03 (0%)
1.03 (0%)
no data
g/dL
40.7 (0%)
40.7 (0%)
no data
40.7 (0%)
Serum gamma-tocopherol
g/dL
no data
10.7 (0%)
Serum alpha-carotene
g/dL
no data
0.7 (9%)
no data
0.7 (7%)
Serum trans-beta-carotene
g/dL
no data
no data
Serum cis-beta-carotene
g/dL
no data
0.7 (52%)
no data
0.7 (51%)
Serum beta-cryptoxanthin
g/dL
no data
no data
g/dL
no data
no data
Serum trans-lycopene
g/dL
no data
no data
g/dL
no data
no data
no data
g/dL
0.2 (16%)
0.2 (2%)
no data
1.3 (22%)
g/dL
0.5 (86%)
0.5 (87%)
no data
0.7 (88%)
nmol/L
no data
3.7 (0%)
3.7 (0%)
3.7 (0%)
mol/L
no data
no data
1.6 (0%)
no data
mol/L
no data
no data
8.2 (0%)
no data
mol/L
no data
no data
23.7 (0%)
no data
mol/L
no data
no data
0.6 (0%)
no data
mol/L
no data
no data
0.2 (0%)
no data
mol/L
no data
no data
0.1 (0%)
no data
Water-Soluble Vitamins
B Vitamins and Related Biochemical Compounds
Serum vitamin C
Serum 25-hydroxyvitamin D
Fatty Acids - Saturated
478
2nd National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population
Indicator
Units
1999-2000
2001-2002
2003-2004
2005-2006
mol/L
no data
no data
0.1 (0%)
no data
mol/L
no data
no data
0.6 (0%)
no data
mol/L
no data
no data
0.3 (0%)
no data
mol/L
no data
no data
5.2 (0%)
no data
mol/L
no data
no data
0.2 (0%)
no data
mol/L
no data
no data
0.3 (3%)
no data
mol/L
no data
no data
0.4 (0%)
no data
mol/L
no data
no data
2.2 (0%)
no data
mol/L
no data
no data
0.2 (0%)
no data
mol/L
no data
no data
0.1 (0%)
no data
mol/L
no data
no data
0.1 (0%)
no data
mol/L
no data
no data
0.2 (0%)
no data
mol/L
no data
no data
0.3 (0%)
no data
mol/L
no data
no data
0.1 (0%)
no data
mol/L
no data
no data
0.2 (0%)
no data
mol/L
no data
no data
0.2 (0%)
no data
mol/L
no data
no data
0.1 (0%)
no data
mol/L
no data
no data
0.1 (0%)
no data
Serum ferritin
ng/mL
1.1 (0%)
1.1 (0%)
3 (1%)
3 (1%)
mg/L
no data
no data
0.5 (0%)
0.5 (0%)
ng/mL
no data
1.0 (0%)
1.0 (0%)
1.0 (0%)
Urinary genistein
g/L
0.3 (6%)
Urinary daidzein
g/L
0.5 (1%)
1.6 (7%)
Urinary equol
g/L
3 (28%)
3.3 (30%)
Urinary O-desmethylangolensin
g/L
0.2 (25%)
0.4 (27%)
0.2 (7%)
0.2 (4%)
Urinary enterodiol
g/L
0.8 (8%)
1.5 (4%)
0.3 (1%)
Urinary enterolactone
g/L
0.6 (2%)
1.9 (1%)
0.1 (0%)
pmol/g Hb
no data
no data
3 (< 1%)
no data
pmol/g Hb
no data
no data
4 (2%)
no data
Trace Elements
Iron-Status Indicators
Urinary iodine
Reference
Taylor JK. Quality assurance of chemical measurements. Chelsea (MI): Lewis Publishing; 1987.
Appendices
479
Appendix G
Selected References of Descriptive NHANES Papers on
Diet-and-Nutrition Biochemical Indicators
Water-Soluble Vitamins
Bailey RL, Mills JL, Yetley EA, Gahche JJ, Pfeiffer CM, Dwyer JT, et al. Unmetabolized serum folic acid and its
relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged >=60 y
in the United States. Am J Clin Nutr. 2010;92:383389.
Bailey RL, McDowell MA, Dodd KW, Gahche JJ, Dwyer JT, Picciano MF. Total folate and folic acid intake from
foods and dietary supplements of US children aged 113 y. Am J Clin Nutr. 2010;92:353358.
Bailey RL, Dodd KW, Gahche JJ, Dwyer JT, McDowell MA, Yetley EA, et al. Total folate and folic acid intake
from foods and dietary supplements in the United States: 20032006. Am J Clin Nutr. 2010;91:231237.
Bentley TGK, Willett WC, Weinstein MC, Kuntz KM. Population-level changes in folate intake by age, sex, and
race/ethnicity after folic acid fortification. Am J Public Health. 2006;96:20402047.
Boulet SL, Yang Q, Mai C, Mulinare J, Pfeiffer CM. Folate status in women of childbearing age by race/ethnicity
United States 19992000, 20012002, and 20032004. Morb Mortal Wkl Rep. 2007;55(51):13771380.
Dietrich M, Brown CJP, Block G. The effect of folate fortification of cereal-grain products on blood folate status,
dietary folate intake and dietary folate sources among adult non-supplement users in the United States. J Am Coll
Nutr. 2005;24:266274.
Ganji V, Kafai MR. Hemoglobin and hematocrit values are higher and prevalence of anemia is lower in the
post-folic acid fortification period than in the pre-folic acid fortification period in US adults. Am J Clin Nutr.
2009;89:363371.
Ganji V, Kafai MR. Demographic, lifestyle, and health characteristics and serum B vitamin status are determinants
of plasma total homocysteine concentrations in the post-folic acid fortification period, 19992004. J Nutr.
2009;139:345352.
Ganji V, Kafai MR. Trends in serum folate, RBC folate, and circulating total homocysteine concentrations in the
United States: analysis of data from National Health and Nutrition Examination Surveys, 19881994, 19992000,
and 20012002. J Nutr. 2006;136:153158.
Ganji V, Kafai MR. Population reference values for plasma total homocysteine concentrations in US adults after
the fortification of cereals with folic acid. Am J Clin Nutr. 2006;84:989994.
Ganji V, Kafai MR. Population references for plasma total homocysteine concentrations for US children and
adolescents in the post-folic acid fortification era. J Nutr. 2005;135:22532256.
Ganji V, Kafai MR. Serum total homocysteine concentration determinants in non-Hispanic white, non-Hispanic
black, and Mexican-American populations of the United States. Ethn Dis. 2004;14:476482.
Ganji V, Kafai MR. Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine
concentrations in the Third National Health and Nutrition Examination Survey, 19881994. Am J Clin Nutr.
2003;77:826833.
Hamner HC, Mulinare J, Cogswell ME, Flores AL, Boyle CA, Prue CE, et al. Predicted contribution of folic acid
fortification of corn masa flour to the usual folic acid intake for the US population: National Health and Nutrition
Examination Survey, 20012004. Am J Clin Nutr. 2009;89:305315.
McDowell MA, Lacher DA, Pfeiffer CM, Mulinare J, Picciano MF, Rader JI, et al. Blood folate levels: The latest
NHANES results. NCHS data briefs, no 6. Hyattsville, MD: National Center for Health Statistics. 2008.
Morris MS, Jacques PF, Rosenberg IH, Selhub J. Circulating unmetabolized folic acid 5-methyltetrahydrofolate
in relation to anemia, macrocytosis, and cognitive test performance in American seniors. Am J Clin Nutr.
2010;91:17331744.
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Appendices
483
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