SIGMA-ALDRICH

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 4.1 Revision Date 10.09.2011 Print Date 27.04.2012

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product name Product Number Brand Company : : : :

Titanium(IV) oxide
718467 Aldrich Sigma-Aldrich Pty. Ltd. 12 Anella Avenue CASTLE HILL NSW 2154 AUSTRALIA +61 2 9841 0555 (1800 800 097) +61 2 9841 0500 (1800 800 096) +44 (0)8701 906777 (1800 448 465)

Telephone Fax Emergency Phone # 2. HAZARDS IDENTIFICATION

: : :

Classified as hazardous according to criteria of NOHSC. - HAZARDOUS SUBSTANCE. NONDANGEROUS GOODS. This substance is not classified as dangerous according to Directive 67/548/EEC. 3. COMPOSITION/INFORMATION ON INGREDIENTS Formula Molecular Weight CAS-No. EC-No. : : TiO2 79.87 g/mol Index-No. Classification Concentration -

Titanium dioxide 13463-67-7 236-675-5 4. FIRST AID MEASURES

General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 5. FIRE-FIGHTING MEASURES Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
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Special protective equipment for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions Do not let product enter drains. Methods for cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 7. HANDLING AND STORAGE Handling Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Storage Store in cool place. Keep container tightly closed in a dry and well-ventilated place. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Components with workplace control parameters Components CAS-No. Value Control parameters Titanium dioxide 13463-67-7 TWA 10 mg/m3

Update 2005-08-01

Basis Australia. Adopted National Exposure Standards for Atmospheric Contaminants in the Occupational Environment

Remarks

See chapter 14 This value is for inspirable dust containing no asbestos and < 1% crystalline silica (see Chapter 14) ACGIH is the documentation source

Personal protective equipment Respiratory protection Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Eye protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin and body protection Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
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Hygiene measures Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Form Colour Odour Safety data pH Melting point Boiling point Flash point Ignition temperature Lower explosion limit Upper explosion limit Water solubility no data available 1,850 C no data available not applicable no data available no data available no data available no data available powder white odourless

10. STABILITY AND REACTIVITY Storage stability Stable under recommended storage conditions. Materials to avoid Strong acids Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Titanium/titanium oxides Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION Acute toxicity LD50 Oral - rat - > 10,000 mg/kg LD50 Dermal - rabbit - > 10,000 mg/kg Irritation and corrosion Skin - Human - Mild skin irritation - 3 h Eyes - rabbit - No eye irritation Sensitisation Will not occur Chronic exposure Carcinogenicity - rat - Inhalation Tumorigenic:Carcinogenic by RTECS criteria. Lungs, Thorax, or Respiration:Tumors. Carcinogenicity - rat - Intramuscular Tumorigenic:Neoplastic by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors at site or application.
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IARC:

2B - Group 2B: Possibly carcinogenic to humans (Titanium dioxide)

Genotoxicity in vitro - Hamster - ovary Micronucleus test Genotoxicity in vitro - Hamster - Lungs DNA inhibition Genotoxicity in vitro - Hamster - ovary Sister chromatid exchange Genotoxicity in vivo - mouse - Intraperitoneal Micronucleus test no data available

Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Potential Health Effects Inhalation Skin Eyes Ingestion Additional Information RTECS: XR2275000 12. ECOLOGICAL INFORMATION Elimination information (persistence and degradability) no data available Ecotoxicity effects Toxicity to fish Toxicity to daphnia and other aquatic invertebrates. LC50 - other fish - > 1,000 mg/l - 96 h EC50 - Daphnia magna (Water flea) - > 1,000 mg/l - 48 h May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. May be harmful if swallowed.

EC0 - Daphnia magna (Water flea) - 1,000 mg/l - 48 h Further information on ecology no data available 13. DISPOSAL CONSIDERATIONS Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. 14. TRANSPORT INFORMATION ADR/RID Not dangerous goods
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IMDG Not dangerous goods IATA Not dangerous goods 15. REGULATORY INFORMATION Labelling according to EC Directives

Further information: This substance is not classified as dangerous according to Directive 67/548/EEC. 16. OTHER INFORMATION Further information Copyright 2011 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

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