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Flucytosine
C.Disruptsmicrotubulefunction
Griseofulvin
IVadministrationresultsinaplasmahalflifeofabout24hours f f f
Excretedveryslowlyintheurine TherapeuticUses:mosteffectivedrugforsystemicfungalinfection Usedforthetreatmentoflifethreateningfungalinfection
topicalformulations
AdverseEffects: hypersensitivityreactions,normochromicnormocytic anemia, feverchills,headacheandGIdisturbanceswithIVadministration fever chills headache and GI disturbances with IV administration
thrombophlebitis
F.Naftidine syntheticantifungalagentisanallylamine h i if l i ll l i MechanismofAction:decreasesthesynthesisofergosterol byinhibiting squalene peroxidase
Fungistatic againstyeasts
Usedtotreattinea pedis,cruris,corporis Itisnoteffectiveforfungalinfectionsofthehairandnails It is not effective for fungal infections of the hair and nails Preparation: cream AdverseEffects:burning,dryness,rednessanditchiness G.Miconazole andCotrimazole Imidazole derivatives Topicalagents p g InhibitthegrowthofcommonDermatophytes includingTrichophyton, Epidermophyton floccosum,C.albicans,Malassezia furfur,ringwormand otherskininfections,vulvovaginal candidiasis, , g ,