Safety of t-PA in stroke and Rett syndrome. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Andy Southerland interviews Dr. Sean Savitz about his paper on safety of t-PA in stroke. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about ophthalmoplegia in herpes zoster ophthalmicus. In the next part of the podcast Dr. Alberto Espay interviews Dr. SakkuBai Naidu for our Lesson of the Week about Rett syndrome. In concluding, there is a brief statement where to find other up-to date patient information and current Patient Page. The participants had nothing to disclose except Drs. Savitz and Espay. Dr. Savitz serves on a scientific advisory board for Grupo Ferrer Internacional S.A.; has received travel expenses and/or honoraria for lectures or educational activities not funded by industry; serves as an Associate Editor of Experimental and Translational Stroke Medicine; has received honoraria from Johnson & Johnson; receives research support from Athersys, the NIH R21NS064316 [PI] and R21 HD060978 [PI], the American Heart Association, and from the Howard Hughes Medical Institute.Dr. Espay received has personal compensation as a consultant for Boehringer Ingelheim; grant support from Codman; Medtronic, Inc; Allergan, Inc.; and CleveMed, and honoraria from UCB-SCHWARZ PHARMA AG; Medtronic, Inc. and Novartis.