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METABOLISM
Overview
DNA & RNA needed for
Protein synthesis & Cell proliferation
Carriers of activated intermediates
(CoA, FAD, NAD, NADP)
Second messengers (cAMP, cGMP)
Energy currency of a cell ATP
Nucleotides can be synthesized de novo
or can be obtained by salvage pathways
PYRAMIDINE SYNTHESIS &
DEGRADATION
1st the pyramidine ring is formed
Next the sugar moiety i.e ribose-5
po4 is added
Pyramidine ring is formed by
Glutamine, Aspartic acid & Co2
Carbamoyl Po4 Synthetase II
present in the cytoplasm is rate
limiting enzyme
ATP activates & UTP inhibits CPS II
CPS I CPS II