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DR. SULEIMAN DABIT HEAD OF ART AND GENETIC DEPARTMENT AL KHALIDI MEDICAL CENTER
Questions?
What vitamins are good for women to become more fertile? What kinds of vitamins can men take to increase fertility? What can I take to increase sperm mobility?
Endogenous
Metabolism Inflammation Infections Diseases Respiratory burst Hypoxiareperfusion Stress
Exogenous
Smoking Pollution Radiation Drugs Food additives Insecticides Pesticides
Atherosclerosis
Alzheimer
Liver disease
Threatened abortion
Diabetic nephropathy
Diabetic neuropathy
Antioxidant
(Donor Factor Protective Factor)
A molecule which prevents or slows down oxidation by donating electron to free radical while staying stable
Oxidative Stress
Affects Multiple Physiological Processes
Embryo Development And Pregnancy*
Oxidative Stress
Is A Common Pathology In Approximately
50%
Of Infertile Men*
Infertility
Has Significantly*
Higher Levels Of ROS & Lower Levels Of Protective Antioxidants Within Their Semen
Leadin g To
Free Radicals
When DNA is attacked, it can be also altered by free radicals. Ovum and sperm cells can be affected by free radical damage so are the reproductive organ and glands that produce reproductive hormones
DNA Fragmentation
Damaged DNA can cause miscarriages or birth defects and developmental problems for the future child.
This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library, 2011, Issue 11
Background Between 30% to 80% of male subfertility cases are considered to be due to the damaging effects of oxidative stress on sperm. Oral supplementation with antioxidants may improve sperm quality by reducing oxidative stress. Objectives This Cochrane review aimed to evaluate the effect of oral supplementation with antioxidants for male partners of couples undergoing assisted reproduction techniques (ART). Search strategy This Review searched the Cochrane Menstrual Disorders and Subfertility Group Register, CENTRAL (The Cochrane Library), MEDLINE, EMBASE, CINAHL, Psyc INFO and AMED databases (from their inception until February 2010), trial registers, sources of unpublished literature, reference lists and they asked experts in
Oxidative stress may cause sperm cell damage. This damage can be reduced by the bodys own natural antioxidant defences.
Antioxidants can be part of our diet and taken as a supplement. It is believed that in many cases of unexplained subfertility, and also in instances where there may be a sperm-related problem, taking an oral antioxidant supplement may increase a couples chance of conceiving when undergoing fertility treatment. This review identified 34 randomised controlled trials involving 2876 couples. Pooled findings support increases in live births and pregnancy rates with the use of antioxidants by the male partner.
Antioxidants
Antioxidants neutralize the free radicals, stopping further damage from happening and protecting the cells health. Work as a defense system, disarming free radicals
Vitamin C
An antioxidant that protects tissue from damage and helps body absorb iron: builds healthy immune system . Citrus fruits, red pepper, green beans, strawberries, broccoli, tomatoes, cabbages.
Vitamin E
Increase sperm health and motility Help protect sperm and egg integrity. Found in raw vegetables oils, nuts, green leafy vegetables.
Zinc
Helps produce insulin and enzymes. Is essential in sperm production. Red meats, poultry, beans, nuts, whole grains, fortified cereals, oysters, dairy products . In men, increasing levels of Zinc lead to boost sperm levels, improve the form, function and quality of male sperm Decrease male infertility
Gingko Biloba
Is one of the longest living trees on the planet (1000 years). Memory herb. Improve sexual function. Prevent leading cause of male impotence (atherosclerosis). Improve erection in men. Help to bring fresh blood to the reproductive system in women.
Thiamin/B1
Raises energy level and regulates nervous system . Whole grain, fortified cereals, wheat germ, organ meats, eggs, rice, pasta, berries, nuts, legumes, pork .
Riboflavin/B2
Maintains energy, good eyesight, healthy skin . Meats, poultry, fish, dairy products, fortified cereals, eggs.
Niacin/B3
Promotes healthy skin, nerves and digestion. High-protein foods, fortified cereals and breads, meats, fish, milk, eggs, peanuts.
Pyridoxine/B6
Helps form red blood cells, helps with morning sickness. Chicken, fish, liver, pork, eggs, soybeans, carrots, cabbage, cantaloupe, peas, spinach, wheat germ, sunflower seeds, bananas, beans, broccoli, brown rice, oats, bran, peanuts, walnuts.
CoQ10
Involved in the production of ATP Increase sperm motility in semen Found in salmon and organ meat
Protein
Helps in the production of amino acids; repairs cells. Most animal foods, meat, poultry, eggs, dairy products, beans, legumes, nuts.
* Nutritional deficiencies have been linked to ovulation issues, hormonal imbalances, poor egg quality. * Vitamins play a significant role in fertility because they help balance hormones and organs functioning at an optimal level.
Vitamin C Omega 3 Zinc Selenium Iron Folic acid Calcium Vitamin B6 DHEA Glutathion.
Pregnant women should have a diet that consist of a variety of foods including:
Proteins, Vitamins, Carbohydrates, Minerals, Fats.
Omega 3
Contain two acids DHA and EPA Low levels of DHA is linked to depression and other mental health issues. During pregnancy, a lack of DHA may be associated with premature birth, low birth weight and hyperactivity in children. Found in Sardines, walnuts, shrimp and salmon.
Selenium
An antioxidant that helps to protect the eggs and sperms from free radicals which can cause miscarriages and birth defects. Necessary for the creation of sperm.
Iron
Increase fertility by helping to balance ovulation. Women at childbearing age are at risk for developing iron deficiency anemia because menstruation, pregnancy and lactation all deplete the body natural stores of iron.
Iron
Helps in the production of hemoglobin; prevents anemia, low birth weight, and premature delivery. Beef, pork, dried beans, spinach, dried fruits, wheat germ, oatmeal or grains fortified with iron. Recommended preconceptional dose is15mg daily.
Folic Acid/Folate
Helps support the placenta, and prevents spina bifida and other neural tube defects . Oranges, orange juice, strawberries, green leafy vegetables, spinach, broccoli, cauliflower, fortified cereals, peas, pasta, beans, nuts. Recommended daily dose is 400mcg.
Calcium
Creates strong bones and teeth, helps prevent blood clots, helps muscles and nerves function. Yogurt, milk, cheddar cheese, calcium-fortified foods like soy milk, juices, breads, cereals, dark green leafy vegetables, canned fish with bones.
Arginine (L-Arginine)
It is beneficial for improving fertility. It is an amino acid that provides blood flow for the uterus, ovaries and genitals. Create a healthy environment in the uterus for embryo implantation. Increase the production of stretchy, egg-white like fertile mucus. Recommended daily dose is 16g.
Vitamin B6
Essential for restoring hormonal balance and increasing fertility in women. Helps balance the progestrone levels in women who are having problems conceiving Has the ability to lengthen a women luteal phase. The daily recommended dose of vitamin B6 is 100mg.
Glutathione
Natural master antioxidant and detoxifier. Most important defender of a cell immune system. Helpful for those who are experiencing immunological miscarriages or if their body is rejecting your mates sperm.
The best way to increase glutathione levels is to take 100mg of lipoic acid a day. Found in fresh fruits, vegetables and freshly cooked meat.