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List of Experiments
Exp. 1: Bone Mechanics Exp. 2: Soft Tissue Mechanics Exp. 3: Pressure Pulse Propagation in Arteries Exp. 4: Pressure Wave Velocity in Arteries Exp. 5: Mechanical Properties of Bioresorbable Polymers
Requirements
Take midterm and final exams. Attend all 5 laboratory sessions & submit all background & Protocol and final reports (use predefined formats). Sign a safety form.
Grading
Final grade: 60% Experiments 20% Midterm Exam 20% Final Exam Each experiment: 70% Final Lab Reports 20% Initial Background & Protocol lab reports 10% Oral Quiz, Background & Protocol
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Why Statistics?
Easy way to sum up data. Enables you to compare data from your
experiments.
What is Statistics?
Sources of Uncertainty
Random error
Environmental variations. Limitations of human sensing ability (unavoidable). Noise in the process, random unstableness in the experimental system.
Common Statistics
Mean (the average) a measure of where the center of your distribution lies. It is simply the sum of all observations divided by the number of observations.
Median (2nd quartile or 50th percentile) the middle value. 50% of values are above and 50% below the median. If N is an odd number, then the median is the middle value. if N is an even number, then the median is half way between the two middle values.
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Standard Deviation (SD) a measure of how far the observations in a sample deviate from the mean. It is analogous to an average distance (independent of direction) from the mean. Variance the square value of SD.
Var SD
2
( xi x) 2 n 1
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Example
Measured data: 1, 4, 4, 4, 5, 18, 20
1 4 4 4 5 18 20 8 Mean= 7
(1 8) 2 3 (4 8) 2 (5 8) 2 (18 8) 2 (20 8) 2 7.63762 7 1
SD =
Median = 4
Variance = SD2=58.33333
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Normal Distribution
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1 SD from the mean is ~68.2% Interval 2 SD from the mean is ~95.4% Interval 1.96 SD from the mean is 95% Interval
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SE Mean is an estimation of the dispersion that you would observe in the distribution of sample means, if you continued to take samples of the same size from the population.
SEMean SD / N
(N number of data points)
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We interpret an interval calculated at a 95% level, as we are 95% confident that the interval contains the true population mean. We could also say that 95% of all confidence intervals formed in this manner (from different samples of the population) will include the true population mean.
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In general, you compute the 95% confidence interval for the mean with the following formula:
Lower limit = M - Z.95m Upper limit = M + Z.95m
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Example Cont.
The sampling distribution of the mean has a mean of 90 and a standard deviation of 36/3 = 12.
95% Interval = 1.96 SD
90 - (1.96)(12) = 90-23.52=66.48
90 + (1.96)(12) = 90+23.52= 113.52
The middle 95% of the distribution is shaded
If we compute the mean (M) from a sample, and create an interval ranging
CI x
ts n
DF 2
3 4
0.95 4.303
3.182 2.776 2.571 2.306 2.228
0.99 9.925
5.841 4.604 4.032 3.355 3.169
CL = Confidence Limit
5 8 10
Abbreviated t table 20
Example Cont.
The probability for 95% confidence is p=0.05 DF=n-1, n=10, DF=9 t = TINV(p,DF)=2.262159 Mean = 10.35 SD = 0.623592 CL = 0.446
CI=10.350.45
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Test of Significance
How can we determine whether the data agrees with the theoretical value or not? t-test test of significance
t test x x
n/s
For this type of analysis to be valid, both samples we are comparing should be drawn from the same population with the same distribution of variance.
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Example
Does the mean value of the example agrees with the theoretical value 10.2 GPa? (10.35-10.2)100.5/0.632=0.075 < 2.262
ttest=
t-Test
The t-test assesses whether the means of two groups are statistically different from each other.
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t-Test Cont.
Hypothesis Testing
The null hypothesis for the test is that all population means (level means) are the same. Ho: 1 - 2 = 0
The alternative hypothesis is that one or more population means differ from the others. H1: 1 - 2 0
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Fourth step: determine the probability value for the computed t-value
using a t table.
Excel: =TTEST()
2 1,3
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Excel:
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Regression
Regression analysis (curve fitting)- the objective technique for evaluating the best fit of data. Linear regression with linear relationship Y=a+bX.
The regression line is obtained by minimizing the sum of the actual data squared deviations from the best-fit line. The aim is to find coefficients a & b, that minimize the expression.
(Y
i 1
Y ) (Yi (a bX i ))
2 i 1
2
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R2-value
Excel:
RMB/Add Trendline
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a b
R Square- closer to 1, better the fit Standard Error- closer to 0, better the fit
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Correlation Example
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Experimental Design
For experimental design, we want to have a way to estimate the uncertainty inherent in the measurements, due to the nature of the equipment or method used:
Y=A X1X2X3
Y-dependent variable, Xs measured independent variables, A -constant. The change in Y due to a change in any of the Xs will be:
In this example Y is distance, X1 is velocity, & X2 is time. Accordingly, the fractional distance uncertainty is: (DY/50)max = 0.1/10 + 0.05/5 = 0.02 = 2%
(DY)max = 1 m
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Background:
Hypothesis:
The internal compression stress in the bone-soft tissue interface is higher than the superficial compression stress in the shoe-heel interface.
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Method:
The two kinds of compression stresses were measured and computed during gait in the calcaneus
region.
For the purpose of comparison, the peak compression stress of each gait cycle was collected.
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Results:
Some References
http://davidmlane.com/hyperstat
http://www.statsoft.com/textbook/stathome.html http://helios.bto.ed.ac.uk/bto/statistics/tress4a.html
http://www.stat.yale.edu/Courses/1997-98/101/confint.htm
http://www.phys.selu.edu/rhett/plab193/labinfo/Error_Analysis /05_Random_vs_Systematic.html
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