PATHOGENOMIC RESEARCH IN HUNGARY PRESENT STAGE AND PERSPECTIVES

Ideas for cooperation L. Emdy - B. Nagy

ERE-NET PathoGenoMics Meeting

Bonn, 07.-08. April, 2005

CENTERS OF PATHOGENOMIC RESEARCH IN HUNGARY

IDEAS FOR FUTURE COOPERATION FIELDS WITH HUNGARIAN PARTNERS

Enterobacterial pathogenomics:
Human intestinal and extraintestinal E. coli, Salmonella, Yersinia Univ. Med. Sch. Pcs, Dept. Med.Microbiol. Immunol. Contact person: Levente Emdy, levente_emody@yahoo.co.uk Veterinary aspects of E. coli and Salmonella Vet. Med. Res. Inst., Hungarian Acad. Sci. Contact person: Bla Nagy, bnagy@vmri.hu Genome plasticity of Escherichia coli: genome evolution studies Biol. Res. Ctr. Szeged Contact person: Gyrgy Psfai, posfaigy@nucleus.szbk.u-szeged.hu

IDEAS FOR FUTURE COOPERATION FIELDS WITH HUNGARIAN PARTNERS (ctnd)

Gram positive pathogens: pathogenomics and resistance mechanisms

Staphylococcus, Streptococcus (including pneumococci), Enterococcus

Contact person: Ferenc Rozgonyi, rozfer@net.sote.hu Anaerobes: pathogenomics and resistance mechanisms Bacteroides spp. Clostridium difficile Univ. Med. Sch., Szeged, Dept. Clin. Microbiol. Contact person: Elisabeth Nagy, nagye@mlab.sote.u-szeged.hu

IDEAS FOR FUTURE COOPERATION FIELDS WITH HUNGARIAN PARTNERS (ctnd) Helicobacter pylori: interactions governed by genetic makeup of the host and parasite

Univ. Med. Sch. Szeged, Dept. Med. Microbiol. Immunobiol.

Contact person: Yvette Mndi, yvette@comser.szote.u-szeged.hu Mycobacteria: molecular mechanisms of reactivation Univ. Med. Sch. Szeged, Dept. Med. Microbiol. Immunobiol. Contact person: Andrs Miczk, miczak@comser.szote.u-szeged.hu Chlamydia pneumoniae: genetic factors involved in the development of atherosclerosis

National Center for Epidemiology

Contact person: va Gnczl, gonczole@oek.antsz.hu

IDEAS FOR FUTURE COOPERATION FIELDS WITH HUNGARIAN PARTNERS (ctnd) Fungal pathogens: genetic background of virulence, and development of new antifungal agents Univ. Szeged, Fac. Sci. Dept.Microbiol. Contact person: Csaba Vgvlgyi, csaba@bio.u-szeged.hu Univ. Debrecen, Fac. Sci. Dept. Microbiol. Contact person: Pcsi Istvn, pocsi@tigris.unideb.hu

Univ. Med. Sch. Debrecen, Dept. Med. Chem

Contact person: Viktor Dombrdi, dombradi@jaguar.unideb.hu Univ. Pcs, Fac. Sci. Dept. Gen. Envirol. Mirobiol.

Contact person: Mikls Pesti, micro@ttk.pte.hu

Hungarian Scientific Research Fund (OTKA) grants involving pathogenomic topics:

Attenuation of Escherichia coli by global regulatory mutations. (Emdy L.) Investigations on the pathogenicity of enteroinvasive bacteria. (Pl T.) Investigations with a regulatory mutant vaccine candidate Salmonella enterica strain eliciting cross-immunity in mice. (Nagy G.) The role of horizontal gene transfer in the evolution of enterotoxic and cytotoxic Escherichia coli bacteria. (Nagy B.) Occurence in Hungary, and molecular biological characterization of cytolethal distending toxin (CDT), a new cytotoxin.(Tth I.) Investigations on genome-evolution and plasticity by genome reduction. (Psfai G.) Investigations on the mechanism of human enterobacterial infections. (Gyrffy Z.) Multi-drug resistence types in Pseudomonas aeruginosa. (Szab D.)

Hungarian Scientific Research Fund (OTKA) grants involving pathogenomic topics (ctnd):

In vitro and in vivo pathogenomic studies on methicillin resistant and methicillin sensitive Staphylococcus aureus strains. (Rozgonyi F.)
Molecular biological studies on virulence factors of bacteria causing anaerobic infections. (Nagy E.) Cytokine gene polymorphism in diseases of microbial and complex origin. (Mndi Y.) Reactivation of mycobacteria. (Miczk. A.) Genetic background of the relationship between atherosclerosis and Chlamydia pneumoniae. (Gnczl .)

Hungarian Scientific Research Fund (OTKA) grants involving pathogenomic topics (ctnd):

Studies on fungal metabolism in order to develop new type antimycotic agents. (Pcsi I.)

Regulation of autolytic processes in Aspergillus nidulans. (Pcsi I.)

Hungarian partners in international grants involving pathogenomic topics:

EU FP6. Network of Excellence. European Virtual Institute for Functional Genomics of Bacterial Pathogens (EuroPathoGenomics). Coordinator: J. Hacker, University of Wrzburg, Hungarian coordinator: B. Nagy. Partner 23: B. Nagy, Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest Partner 24: L. Emdy, University Medical School, Pcs EU FP6. Salmonella free broiler by live vaccine induced innate resistance to colonization and invasion and novel methods to eliminate vaccine and field strains (SUPASALVAC) Coordointor: P.A.Barrow CR5. partner, (WP1 leader): B. Nagy, Veterinary medical Research Institute, Hungarian Academy of Sciences, Budapest

Hungarian partners in international grants involving pathogenomic topics (cntd):

Bilateral German-Hungarian Science and Technology Grant. (J. HackerL. Emdy): Studies on urinary Escherichia coli infections in order to develop new diagnostic, therapeutic and preventive measures. Bilateral German-Hungarian Science and Technology Grant. (J. HackerB. Nagy): Studies on virulence genes of enterotoxigenic and verotoxigenic Escherichia coli: new opportunities for prevention of disease and for increased food safety. Bilateral Austrian-Hungarian Science and Technology Grant. (F. Rozgonyi): In vitro and in vivo studies on the pathomechanism and pathogenesis of community acquired and nosocomial S. aureus infections. Bilateral British-Hungarian Science and Technology Grant. (F. Rozgonyi): Antibiotic sensitivity and molecular typing of Streptococcus pneumoniae strains isolated in Hungary.