SEXUALLY TRANSMITTED VIRUSES WHICH ARE INFECTED UROGENITAL

Muhammad Asaad Maidin

DEPARTEMENT OF MICROBIOLOGY FACULTY OF MEDICINE, HASANUDDIN UNIVERSITY

SEXUALLY TRANSMITTED VIRUSES WHICH ARE INFECTED UROGENITAL

*Molluscum contagiosum
Human papilomavirus : Kondiloma akuminata Human herpes viruses : Herpes simplex virus tipe2 (Herpes genitalia) HIV/AIDS Hepatitis-B dan Hepatitis C

SEXUALLY TRANSMITTED VIRUSES WHICH ARE INFECTED UROGENITAL

A. Molluscum contagiosum

is a benign epidermal tumor that occurs only in humans.

Etiologi : Molluscum contagiosum virus

Important properties of Molluscum contagiosum

ds DNA A disk-shaped core with in a double

membrane Lipoprotein envelope Virion contains DNA dependent RNA polymerase Member of Poxvirus family Diameter 230X300 nm

Incubation period 14- 50 days. The lesions as a pearly white, painless

nodule 0,5 cm in diameter, oval or umbilicated - The nodules are found on the face, scalp,
arms , leg and genitalia. - Spread direct contact and varietry of vehicle. - Children are more often infected than adults. - Poor hygiene spread within families.

Orf virus ( parapox virus) DNA, 300nm, envelope

Papul, nodul, pearly white / warna kulit, umbilicated

B. Condyloma Accuminata
Sexually transmitted disease that

caused by several strains Human

papilomavirus spesific lesion :

fibroepitelioma on the skin and membrane mucosa.

Etiology : Human papiloma virus (HPV)

> 70 tipe
The often important cause :

Low grade type : HPV-6 & HPV-11 High grade type : HPV-16, 18, 31, 33 Carsinoma cervics

Human Papilloma Virus

Properties of HPV (1)
Genom

: DNA Virus Transmission : Skin contact, fomites, anogenital, peripartum, or because of acquired immunocompromisation Type 6 and 11

PROPERTIES OF HPV(2)
Icosahedral nucleo capsid
Non envelope
Members of Papovavirus family
At least 100 types

PROPERTIES OF HPV(3)
E6 and E7 genes are implicated in carcinogenesis. They encode proteins that inacivate proteins encoded by tumor suppressor genes in human cells. p53 and Retinoblastoma(RB) genes are tumor suppressor genes in human cells. Inactivation of p53 and RB proteinsthe step in which a normal cell becomes a cancer cell. Approximately 30 types of HPV infect the genital tract.

4 type morphologic Condylomata :

1. Accuminata cauliflower 2. Papular warts papulae 3. Keratotic warts keratotic seborchoic 4. Flat-topped papules maculae

Human Papilloma Virus

Electron Photomicrograph of Human Papillomavirus

Human Papilloma Virus

Kondiloma akuminata di batang penis, meatus urethra

Cauliflower warts

C. Herpes genital

Etiology : family herpesviridae

herpes simplex virus(HSV) type 1 herpes labialis herpes simplex virus(HSV) type 2 herpes genital

CLASSIFICATION OF HUMAN HERPESVIRUSES

Subfamily -herpes virinae

Biologic Properties Growth Cycle & Cytophatology Short, cytolytic Latent infections Neurons

Genus -virus

Official Name Human herpesvirus

Common Name

Alpha

Simplex

2
Varicello Cytomegalo Roseolo 3 5 6 7 4 8

Beta

Long, cytomegalic Long, lymphoproliferative Variable, lymphoproliferative

Glands, kidneys Lymphoid tissue

Herpes simplex virus type 1 Herpes simplex virus type 2 Varicella-zoster virus Cytomegalovirus Human herpesvirus 6 Human herpesvirus 7 Epstein-Barr virus Kaposis sarcoma associated herpesvirus

Gamma

Lymphoid tissue

Lymphocrypto Rhadino

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia, Fera

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera

Herpes simplex, DNA,150-200nm Envelope, Icosahedral,

PROPERTIES OF VIRUS

Morphologically identical to herpes simplex virus The virus causess chickenpox and zoster same, no significant genetic variation
Virion : spherical, 150-200 nm in diameter (icosahedral) Genome : ds DNA, linear, 124-235 kbp Replication : Nucleus, bud from nuclear membrane Outstanding characteristics: Establish latent infections Persist indefinitely in infected hosts Frequently reactivated in immunosuppressed hosts some are cancer-causing
Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia, Fera

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera

VIRAL REPLICATION CYCLE

- ACTIVE INFECTION - LATENT INFECTION

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia, Fera

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera

HERPES SIMPLEX VIRUS

Famili : HERPESVIRIDAE SubFamili : ALPHAHERPESVIRINAE Genus : SIMPLEX VIRUS

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia, Fera

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera

Herpes Simplex Virus Type 2

Genome

: DNA virus Family : Herpesviridae Group : Alphaherpesvirus Reservoir : human Transmission : genitalia secret

Herpes Simplex Virus Type 2

Electron micrograph of herpes simplex virus type 2

HERPES SIMPLEX TYPE 2

Genital herpes adult man

on the vulva of an adult woman

on cervix of an adult woman

Genital herpes lesions may be found on the vulva, vagina or cervix, perineum or buttocks
Herpetic infection of the eye (HSV 1 or 2), primary, recurrent or neonatal eye infections
Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Vulvovaginitis in a child

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia, Fera

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera Ibrahim, Department of

Fera Ibrahim, Department of Microbiology, Medical Faculty, University of Indonesia,Fera

Herpes Simplex Virus Type 2

Recurrent genital herpes caused by herpes simplex virus type 2, showing typical small vesicles.

KOPKUM MAA KAB