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Dr
Zeinab sakkara
THE CARTILAGE
It is a special type of connective
tissue with firm consistency of the extracellular matrix.
some degree of flexibility.
HYALINE CARTILAGE
Perichondrium
It is a vascular connective tissue
membrane which surrounds the cartilage except at the articular surfaces of the joints.
It is formed of 2 layers: (a) Outer fibrous layer (b) Inner chondrogenic layer
Cartilage matrix
General characters: It is rubbery in consistency. It is non vascular but it allows diffusion of oxygen and nutrients from capillaries on the outside to reach the chondrocyte. Tissue fluid constitutes 75% of the weight of the matrix
Staining reaction
The matrix appears homogenous
basophilic by Hx, E due to presence of sulphated glycosaminoglycans. The basophilia is markedly increased around lacunae and cell nests. It is stained metatchromatically by Toluidine blue appear purple. It shows strong PAS positivity.
Components:
It is composed of:
(1) Collagen fibres (Type II): Collagen form
sulphateLinked with core of protein (3) Glycoprotein: Called chondronectin which adheres chondrocytes to the matrix collagen. (4) Protein: called chondrocalcin: which help calcification.
Cartilage cells
There are two types of chondrocytes:
1) Young Chondrocytes:
chondrogenic layer. They are flat cells with open-face nuclei and pale basophilic cytoplasm. They are present singly in their lacunae at the periphery of the cartilage and parallel to the perichondrium.
single and triangular or semicircular (when in groups 2, 4, 8). A group of cells in a single lacuna are called cell nests which may be divided by thin partitions of matrix. They have rounded and open face nuclei.
They have granular, basophilic cytoplasm rich in glycogen, fat and phosphatase enzyme. They can divide and show mitotic figures. They show plenty of mitotic figures.
EM:
They contain rER, ribosomes, well developed Golgi. The surface show short cytoplasm processes.
foetal skeleton. Articular surface of bones. Costal cartilage in the thoracic cage. Nose, trachea, bronchi. Laryngeal cartilage thyroid and cricoid.
Sites:
Auricle of the ear. External auditory meatus. Eustachian tube. Epiglottis. Laryngeal cartilage (aritenoid,
cuniform).
Structure:
It differs from hyaline cartilage in:
Chondrocytes:
They are arranged in rows or columns. They are present singly or in groups inside their lacunae.
Matrix:
It is acidophilic because it contains a great number of coarse type I collagen fibers.
The collagen fibers are arranged in bundles between the rows of chondrocytes.
Sites:
Interverterbal discs. Semilunar cartilage of knee joints. Symphysis pubis. Lips of glenoid cavity. Terminal parts of tendons.
Interstitial growth:
The chondrocytes divide and synthesize the cartilage matrix. It occurs in epiphyseal plates and within articular cartilage. It causes growth of cartilage in length.