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COPD:Definition
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease state characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases, primarily caused by cigarette smoking. Although COPD affects the lungs, it also produces significant systemic consequences.
COPD Entities
Simple chronic bronchitis Asthmatic bronchitis/Chronic asthmatic bronchitis Chronic obstructive bronchitis small airways disease Pulmonary emphysema
Pulmonary Emphysema
Permanent, abnormal distension of the air spaces distal to the terminal bronchiole with destruction of alveolar septae, with or without fibrosis. Reduces lung elastic recoil causing airway collapse and irreversible airway obstruction.
Histology
More CB Pathology
Injured epithelium may release reduced amounts of regulatory products such as ACE or neutral peptidase. Sputum production is stimulated by increased exocytosis from secretory cells, lipid mediators, and inflammatory cell products. Mucin gene expression is amplified by TNFalpha, and secretory cell hyperplasia by the neutrophil enzymes elastase and cathepsin G.
Pathology - Emphysema
Classified by pattern of involvement of the acini distal to terminal bronchiole. Centriacinar or Centrilobular limited to respiratory bronchioles primarily with little change in acinus. Normal aging is associated with this. Panacinar or Panlobular involves both central and peripheral portions of the acinus.
Causative factors
Background - Lung function over time Cigarette smoking Airway responsiveness and Allergy Air Pollution Occupational exposure to environmental dust and organic antigens Infection Antioxidant deficiency Molecular/Genetic risk factors
Cigarette Smoking
Impairs ciliary movement Inhibits alveolar macrophages Leads to hypertrophy and hyperplasia of mucus-secreting glands Probably inhibits antiprotease Acutely increases vagally mediated smooth-muscle constriction
Air Pollution
Increased incidence and higher mortality rates of COPD in industrialized urban areas. Exacerbations of CB clearly related to periods of heavy sulfur dioxide pollution and particulates. Nitrogen dioxide NOT implicated in human airways obstruction.
Occupational Exposures
Environmental dusts gold and coal miners Organic antigens COPD is most common respiratory syndrome in agricultural workers, and there is a 10% prevalence of COPD among farm workers Accelerated decline in lung function among plastics workers exposed to toluene diisocyanate and in carding room workers in cotton mills
Infection
Severe viral pneumonia in childhood may lead to small airways obstruction . Mortality, morbidity, and frequency of ARI are higher in patients with chronic bronchitis.
Antioxidant Deficiency
Oxidizing radicals derive from cigarette smoke or may be released by phagocytes in the lung. Deficiencies of antioxidants vitamins may impair host defenses against oxidative radicals and permit tissue destruction leading to COPD.
Lung inflammation
Anti-oxidants
Anti-proteinases
Oxidative stress
Proteinases
Repair mechanisms
COPD pathology